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Conserved domains on  [gi|452000949|gb|EMD93409|]
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glycosyltransferase family 1 protein [Bipolaris maydis C5]

Protein Classification

COG5017 superfamily protein( domain architecture ID 1903969)

COG5017 superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PssE super family cl49515
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
15-189 1.33e-16

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


The actual alignment was detected with superfamily member NF041548:

Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 72.94  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  15 FVTTGaTAPFTALIESIlspsslDALRQGGFTH-LLVQYGSARdvYTKCSADArahlqssqeqrvlivdgIDFSPDglqa 93
Cdd:NF041548   2 FVTVG-TTRFDSLIKAI------DELIEGLIDYeVTFQIGDGK--YIPKNGEY-----------------FDFLEE---- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  94 qFQLVQRSKGLVISHAGSGSILEALRYQTPLVVVPNTGLLDNHQEELAVAMERNNYLIR-GDVTNLAPAIRRSDEFrvKM 172
Cdd:NF041548  52 -IDEYYKKADLIITHAGAGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVcYDLDELEDAIKEAENF--KP 128

                        170
                 ....*....|....*..
gi 452000949 173 SQFPPITSGKHRETKRF 189
Cdd:NF041548 129 NPYEKNPFFIADEIIDF 145
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
15-189 1.33e-16

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 72.94  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  15 FVTTGaTAPFTALIESIlspsslDALRQGGFTH-LLVQYGSARdvYTKCSADArahlqssqeqrvlivdgIDFSPDglqa 93
Cdd:NF041548   2 FVTVG-TTRFDSLIKAI------DELIEGLIDYeVTFQIGDGK--YIPKNGEY-----------------FDFLEE---- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  94 qFQLVQRSKGLVISHAGSGSILEALRYQTPLVVVPNTGLLDNHQEELAVAMERNNYLIR-GDVTNLAPAIRRSDEFrvKM 172
Cdd:NF041548  52 -IDEYYKKADLIITHAGAGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVcYDLDELEDAIKEAENF--KP 128

                        170
                 ....*....|....*..
gi 452000949 173 SQFPPITSGKHRETKRF 189
Cdd:NF041548 129 NPYEKNPFFIADEIIDF 145
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 13-143 1.03e-14

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 68.51  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949   13 LCFVTtGATAPFTALIESILSPSSLDALRqgGFTHLLVQYGSardvytkcSADARAHLQSSQEQrvLIVDGIDFSPDglq 92
Cdd:pfam04101   1 TILVT-GGSQGARALNELVLSVLPLLELK--GELQVLHQTGK--------GDLEEVKIDYAELG--INYEVFPFIDN--- 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 452000949   93 aqFQLVQRSKGLVISHAGSGSILEALRYQTPLVVVPN----TGLLDNHQEELAVA 143
Cdd:pfam04101  65 --MAEYIKAADLVISRAGAGTIAELLALGKPAILVPNpsaaRGHQDNNAKELVKA 117
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
15-164 2.38e-14

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 67.64  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  15 FVTTGA-TAPFTALIESIlspsslDALRQGGFT--HLLVQYGSARDVYTKCsaDARAHLqssqeqrvlivdgidfSPDGL 91
Cdd:COG5017    3 FVTVGThQLPFDRLVRWV------DELAAEGIIdeEVFVQTGHTTYVPRNA--EAVPFL----------------PPDEF 58

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 452000949  92 QaqfQLVQRSKgLVISHAGSGSILEALRYQTPLVVVPNTGLL----DNHQEELAVAMERNNYLI-RGDVTNLAPAIRR 164
Cdd:COG5017   59 Q---KLIAQAR-LVISHAGMGSILTALKLGKPFILVPRLARYgehvDDHQLETARALEKLGGIIvVEDPADLEAALDE 132
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 104-149 6.78e-05

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 42.59  E-value: 6.78e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 452000949 104 LVISHAGSGSILEALRYQTPLVVVPNTGLLDNHQEELAVAMERNNY 149
Cdd:cd03785  255 LVISRAGASTIAELTAAGKPAILIPYPYAADDHQEANARALEKAGA 300
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
15-189 1.33e-16

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 72.94  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  15 FVTTGaTAPFTALIESIlspsslDALRQGGFTH-LLVQYGSARdvYTKCSADArahlqssqeqrvlivdgIDFSPDglqa 93
Cdd:NF041548   2 FVTVG-TTRFDSLIKAI------DELIEGLIDYeVTFQIGDGK--YIPKNGEY-----------------FDFLEE---- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  94 qFQLVQRSKGLVISHAGSGSILEALRYQTPLVVVPNTGLLDNHQEELAVAMERNNYLIR-GDVTNLAPAIRRSDEFrvKM 172
Cdd:NF041548  52 -IDEYYKKADLIITHAGAGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVcYDLDELEDAIKEAENF--KP 128

                        170
                 ....*....|....*..
gi 452000949 173 SQFPPITSGKHRETKRF 189
Cdd:NF041548 129 NPYEKNPFFIADEIIDF 145
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 13-143 1.03e-14

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 68.51  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949   13 LCFVTtGATAPFTALIESILSPSSLDALRqgGFTHLLVQYGSardvytkcSADARAHLQSSQEQrvLIVDGIDFSPDglq 92
Cdd:pfam04101   1 TILVT-GGSQGARALNELVLSVLPLLELK--GELQVLHQTGK--------GDLEEVKIDYAELG--INYEVFPFIDN--- 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 452000949   93 aqFQLVQRSKGLVISHAGSGSILEALRYQTPLVVVPN----TGLLDNHQEELAVA 143
Cdd:pfam04101  65 --MAEYIKAADLVISRAGAGTIAELLALGKPAILVPNpsaaRGHQDNNAKELVKA 117
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
15-164 2.38e-14

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 67.64  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  15 FVTTGA-TAPFTALIESIlspsslDALRQGGFT--HLLVQYGSARDVYTKCsaDARAHLqssqeqrvlivdgidfSPDGL 91
Cdd:COG5017    3 FVTVGThQLPFDRLVRWV------DELAAEGIIdeEVFVQTGHTTYVPRNA--EAVPFL----------------PPDEF 58

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 452000949  92 QaqfQLVQRSKgLVISHAGSGSILEALRYQTPLVVVPNTGLL----DNHQEELAVAMERNNYLI-RGDVTNLAPAIRR 164
Cdd:COG5017   59 Q---KLIAQAR-LVISHAGMGSILTALKLGKPFILVPRLARYgehvDDHQLETARALEKLGGIIvVEDPADLEAALDE 132
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
77-164 1.28e-05

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 44.46  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 452000949  77 RVLIVDGIDFSpdglqaqfQLVQRSKgLVISHAGSGSILEALRYQTPLVVVPNTGllDnhQEELAVAMERNNY---LIRG 153
Cdd:COG1819  170 NVRVVDYVPQD--------ALLPRAD-AVVHHGGAGTTAEALRAGVPQVVVPFGG--D--QPLNAARVERLGAglaLPPR 236

                         90
                 ....*....|...
gi 452000949 154 DVT--NLAPAIRR 164
Cdd:COG1819  237 RLTaeALRAALRR 249
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 104-174 6.00e-05

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 42.81  E-value: 6.00e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 452000949 104 LVISHAGSGSILEALRYQTPLVVVPNTGLLDNHQEELAVAMERNNY--LIR-GDVT--NLAPAIRR---SDEFRVKMSQ 174
Cdd:COG0707  261 LVISRAGASTVAELAALGKPAILVPLPHAADDHQTKNARALVEAGAavLIPqSELTpeKLAEALEElleDPERLAKMAE 339
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 104-149 6.78e-05

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 42.59  E-value: 6.78e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 452000949 104 LVISHAGSGSILEALRYQTPLVVVPNTGLLDNHQEELAVAMERNNY 149
Cdd:cd03785  255 LVISRAGASTIAELTAAGKPAILIPYPYAADDHQEANARALEKAGA 300
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 103-164 9.48e-05

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 42.15  E-value: 9.48e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 452000949 103 GLVISHAGSGSILEALRYQTPLVVVPNTGllDnhQEELAVAMERNNY---LIRGDVT--NLAPAIRR 164
Cdd:cd03784  309 GAFVTHGGWNSTLEALYAGVPMVVVPLFA--D--QPNNAARVEELGAgveLDKDELTaeELAKAVRE 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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