|
Name |
Accession |
Description |
Interval |
E-value |
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
26-515 |
0e+00 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 600.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 26 QRPNILFIVADDLGFSDIGPFGGNINTPVLDQFSKEGMLFSNFYVLPTCSPTRSALLTGNDNHVAGVGIMSEVSYPavan 105
Cdd:cd16025 1 GRPNILLILADDLGFSDLGCFGGEIPTPNLDALAAEGLRFTNFHTTALCSPTRAALLTGRNHHQVGMGTMAELATG---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDegqipsdrgfeesfallqgggshyadqkplsppqvmdyrvngk 185
Cdd:cd16025 77 KPGYEGYLPDSAATIAEVLKDAGYHTYMSGKWHLGPD------------------------------------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatlpaDFYSTKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSGWDSLRVLRLNNLKALGI 265
Cdd:cd16025 114 -------DYYSTDDLTDKAIEYIDEQKAPDKPFFLYLAFGAPHAPLQAPKEWIDKYKGKYDAGWDALREERLERQKELGL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 266 ISADVN-SFAPSGIPQWSTLSPEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANGVmatty 344
Cdd:cd16025 187 IPADTKlTPRPPGVPAWDSLSPEEKKLEARRMEVYAAMVEHMDQQIGRLIDYLKELGELDNTLIIFLSDNGASAE----- 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 345 pgnadgkylgafnneldnrglpnsfvemgPGWAQASSSPFRLFKSFASEGGIRAPLMIKLPNAAPSPGQWNKSFVHVTDL 424
Cdd:cd16025 262 -----------------------------PGWANASNTPFRLYKQASHEGGIRTPLIVSWPKGIKAKGGIRHQFAHVIDI 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 425 MPTVLQLAEVSYPAQFKEKAVRQPIGKSLLPVLTGtaQEVHADGAGMGWELFERKAYIKGKWKVLRLPAPFSTG-EWQLF 503
Cdd:cd16025 313 APTILELAGVEYPKTVNGVPQLPLDGVSLLPTLDG--AAAPSRRRTQYFELFGNRAIRKGGWKAVALHPPPGWGdQWELY 390
|
490
....*....|..
gi 472840594 504 DLEKDPGEANDL 515
Cdd:cd16025 391 DLAKDPSETHDL 402
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
1-540 |
1.38e-127 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 378.84 E-value: 1.38e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 1 MKKLFPFILAALAACGQKQNeeilPQRPNILFIVADDLGFSDIGPFG-GNINTPVLDQFSKEGMLFSNFYVL-PTCSPTR 78
Cdd:COG3119 1 MKRLLLLLLALLAAAAAAAA----AKRPNILFILADDLGYGDLGCYGnPLIKTPNIDRLAAEGVRFTNAYVTsPVCSPSR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 79 SALLTGNDNHVAGVGimsevsypavANLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLgddegqipsdrgfeesfal 158
Cdd:COG3119 77 ASLLTGRYPHRTGVT----------DNGEGYNGGLPPDEPTLAELLKEAGYRTALFGKWHL------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 159 lqgggshyadqkplsppqvmdyrvngkkiatlpadfYSTKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYI 238
Cdd:COG3119 128 ------------------------------------YLTDLLTDKAIDFLERQADKDKPFFLYLAFNAPHAPYQAPEEYL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 239 DKYKGKfdsgwdslrvlrlnnlkalgiisadvnsfaPSGIPQWSTLSPEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLK 318
Cdd:COG3119 172 DKYDGK------------------------------DIPLPPNLAPRDLTEEELRRARAAYAAMIEEVDDQVGRLLDALE 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 319 QQGLYDNTMIVFMSDNGAngvmattypgnadgkylgafnnELDNRGlpnsfvemgpgwaqassspFRLFKSFASEGGIRA 398
Cdd:COG3119 222 ELGLADNTIVVFTSDNGP----------------------SLGEHG-------------------LRGGKGTLYEGGIRV 260
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 399 PLMIKLPNAAPsPGQWNKSFVHVTDLMPTVLQLAEVSYPAQFkekavrqpIGKSLLPVLTGTAQEVHADgagMGWELFER 478
Cdd:COG3119 261 PLIVRWPGKIK-AGSVSDALVSLIDLLPTLLDLAGVPIPEDL--------DGRSLLPLLTGEKAEWRDY---LYWEYPRG 328
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 472840594 479 K---AYIKGKWKVLRLPAPfsTGEWQLFDLEKDPGEANDLSQQFPALRDSLVNEWLKYAKANDVF 540
Cdd:COG3119 329 GgnrAIRTGRWKLIRYYDD--DGPWELYDLKNDPGETNNLAADYPEVVAELRALLEAWLKELGDP 391
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-529 |
3.80e-104 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 319.87 E-value: 3.80e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGMLFSNFYVL-PTCSPTRSALLTGNdnHVAGVGI------MSEVS 99
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSKfYETPNIDRLAKEGMRFTQAYAAaPVCSPSRASILTGQ--YPARLGItdvipgRRGPP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 100 YPAVANLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFAllqGGGSHYADQKPLSPPQVMD 179
Cdd:cd16144 79 DNTKLIPPPSTTRLPLEEVTIAEALKDAGYATAHFGKWHLGGEGGYGPEDQGFDVNIG---GTGNGGPPSYYFPPGKPNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 180 YRVNGkkiatlPADFYSTKNYTDTLIHYIDKNKGdqKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSGWDSlrvlrlnn 259
Cdd:cd16144 156 DLEDG------PEGEYLTDRLTDEAIDFIEQNKD--KPFFLYLSHYAVHTPIQARPELIEKYEKKKKGLRKG-------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 260 lkalgiisadvnsfapsgipqwstlspeqkaefaKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANGV 339
Cdd:cd16144 220 ----------------------------------QKNPVYAAMIESLDESVGRILDALEELGLADNTLVIFTSDNGGLST 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 340 MATTYPGNAdgkylgafnneldnrglpnsfvemgpgwaqasssPFRLFKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFV 419
Cdd:cd16144 266 RGGPPTSNA----------------------------------PLRGGKGSLYEGGIRVPLIVRWPGVIK-PGSVSDVPV 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 420 HVTDLMPTVLQLAEVSYPAQfkekavrQPI-GKSLLPVLTGTAQEV------------HADGAGMGwelferKAYIKGKW 486
Cdd:cd16144 311 IGTDLYPTFLELAGGPLPPP-------QHLdGVSLVPLLKGGEADLprralfwhfphyHGQGGRPA------SAIRKGDW 377
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 472840594 487 KVLRLpapFSTGEWQLFDLEKDPGEANDLSQQFPALRDSLVNE 529
Cdd:cd16144 378 KLIEF---YEDGRVELYNLKNDIGETNNLAAEMPEKAAELKKK 417
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
28-533 |
3.26e-102 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 314.49 E-value: 3.26e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGpFGGN--INTPVLDQFSKEGMLFSNFYVLPTCSPTRSALLTGNDNHVAGVgimsevsypaVAN 105
Cdd:cd16146 1 PNVILILTDDQGYGDLG-FHGNpiLKTPNLDRLAAESVRFTNFHVSPVCAPTRAALLTGRYPFRTGV----------WHT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGYSgHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFALLQGGGSHYADqKPLSPPQVMDYRVNGK 185
Cdd:cd16146 70 ILGRE-RMRLDETTLAEVFKDAGYRTGIFGKWHLGDNYPYRPQDRGFDEVLGHGGGGIGQYPD-YWGNDYFDDTYYHNGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 KIATlpaDFYSTKNYTDTLIHYIDKNKGdqKPFFIYASYTAPHDPLQAPKEYIDKYKGKfdsgwdslrvlrlnnlkalgi 265
Cdd:cd16146 148 FVKT---EGYCTDVFFDEAIDFIEENKD--KPFFAYLATNAPHGPLQVPDKYLDPYKDM--------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 266 isadvnsfapsgipqwstlspeqkaEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANGVMATTYP 345
Cdd:cd16146 202 -------------------------GLDDKLAAFYGMIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGGVPKRFN 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 346 GNADGKylgafnneldnrglpnsfvemgpgwaqassspfrlfKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTDLM 425
Cdd:cd16146 257 AGMRGK------------------------------------KGSVYEGGHRVPFFIRWPGKIL-AGKDVDTLTAHIDLL 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 426 PTVLQLAEVSYPAQFKekavrqPIGKSLLPVLTGTAQE-------VHADGAGMGWELFERKAYIKGKWKVLRlpapFSTG 498
Cdd:cd16146 300 PTLLDLCGVKLPEGIK------LDGRSLLPLLKGESDPwpertlfTHSGRWPPPPKKKRNAAVRTGRWRLVS----PKGF 369
|
490 500 510
....*....|....*....|....*....|....*
gi 472840594 499 EWQLFDLEKDPGEANDLSQQFPALRDSLVNEWLKY 533
Cdd:cd16146 370 QPELYDIENDPGEENDVADEHPEVVKRLKAAYEAW 404
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-520 |
4.63e-85 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 270.23 E-value: 4.63e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGMLFSNFYVL-PTCSPTRSALLTG-NDNHVAGVGimsevsypavA 104
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQKkIKTPNLDRLAAEGMRFTQHYAGaPVCAPSRASLLTGlHTGHTRVRG----------N 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLG--DDEGqIPSDRGFEESFALL-QGGG-SHYA------DQKPLSP 174
Cdd:cd16145 71 SEPGGQDPLPPDDVTLAEVLKKAGYATAAFGKWGLGgpGTPG-HPTKQGFDYFYGYLdQVHAhNYYPeylwrnGEKVPLP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 175 PQVMDYRVNGKKIATLPADfYSTKNYTDTLIHYIDKNKGdqKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSgwdslrv 254
Cdd:cd16145 150 NNVIPPLDEGNNAGGGGGT-YSHDLFTDEALDFIRENKD--KPFFLYLAYTLPHAPLQVPDDGPYKYKPKDPG------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 255 lrlnnlkalgiisadvnsfaPSGIPQWSTlsPEQKaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDN 334
Cdd:cd16145 220 --------------------IYAYLPWPQ--PEKA---------YAAMVTRLDRDVGRILALLKELGIDENTLVVFTSDN 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 335 GANgvmattypgnadgKYLGAFNNeldnrglPNSFvemgpgwaqASSSPFRLFKSFASEGGIRAPLMIKLPNAAPsPGQW 414
Cdd:cd16145 269 GPH-------------SEGGSEHD-------PDFF---------DSNGPLRGYKRSLYEGGIRVPFIARWPGKIP-AGSV 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 415 NKSFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQEVHADgaGMGWELFERK---AYIKGKWKVLRL 491
Cdd:cd16145 319 SDHPSAFWDFMPTLADLAGAEPPEDID--------GISLLPTLLGKPQQQQHD--YLYWEFYEGGgaqAVRMGGWKAVRH 388
|
490 500
....*....|....*....|....*....
gi 472840594 492 PApfSTGEWQLFDLEKDPGEANDLSQQFP 520
Cdd:cd16145 389 GK--KDGPFELYDLSTDPGETNNLAAQHP 415
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
27-516 |
1.26e-84 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 268.66 E-value: 1.26e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFGG-NINTPVLDQFSKEGMLFSNFYVL-PTCSPTRSALLTGNDNHVAGVgimsevsyPAVA 104
Cdd:cd16026 1 KPNIVVILADDLGYGDLGCYGSpLIKTPNIDRLAAEGVRFTDFYAAaPVCSPSRAALLTGRYPVRVGL--------PGVV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFALLqggGSHyaDQKPLS-----PPQVMD 179
Cdd:cd16026 73 GPPGSKGGLPPDEITIAEVLKKAGYRTALVGKWHLGHQPEFLPTRHGFDEYFGIP---YSN--DMWPFPlyrndPPGPLP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 180 YRVNGKKIATLPADFYS-TKNYTDTLIHYIDKNKGdqKPFFIYASYTAPHDPLQAPKeyidKYKGKFDSGwdslrvlrln 258
Cdd:cd16026 148 PLMENEEVIEQPADQSSlTQRYTDEAVDFIERNKD--QPFFLYLAHTMPHVPLFASE----KFKGRSGAG---------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 259 nlkalgiisadvnsfapsgipqwstlspeqkaefakdmeVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNgang 338
Cdd:cd16026 212 ---------------------------------------LYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDN---- 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 339 vmattypgnadgkylGAFNNELDNRGlpnsfvemgpgwaqaSSSPFRLFKSFASEGGIRAPLMIKLPNAAPsPGQWNKSF 418
Cdd:cd16026 249 ---------------GPWLEYGGHGG---------------SAGPLRGGKGTTWEGGVRVPFIAWWPGVIP-AGTVSDEL 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 419 VHVTDLMPTVLQLAEVSYPAQfkekavrQPI-GKSLLPVLTGTAQEVHADGA--GMGWELFerkAYIKGKWKvLRLP--- 492
Cdd:cd16026 298 ASTMDLLPTLAALAGAPLPED-------RVIdGKDISPLLLGGSKSPPHPFFyyYDGGDLQ---AVRSGRWK-LHLPtty 366
|
490 500 510
....*....|....*....|....*....|...
gi 472840594 493 ---------APFSTGEWQLFDLEKDPGEANDLS 516
Cdd:cd16026 367 rtgtdpgglDPTKLEPPLLYDLEEDPGETYNVA 399
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
28-516 |
2.73e-81 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 259.79 E-value: 2.73e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGpFGGN--INTPVLDQFSKEGMLFSNFYVLPTCSPTRSALLTGndNHVAGVGIMSEVSYPAVAN 105
Cdd:cd16029 1 PHIVFILADDLGWNDVG-FHGSdqIKTPNLDALAADGVILNNYYVQPICTPSRAALMTG--RYPIHTGMQHGVILAGEPY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LpgysghLNNQVVTIPELLRESGYHTYMAGKWHLG-DDEGQIPSDRGFEESFALLQGGGSHYADQKPLSPPQVMDYRVNG 184
Cdd:cd16029 78 G------LPLNETLLPQYLKELGYATHLVGKWHLGfYTWEYTPTNRGFDSFYGYYGGAEDYYTHTSGGANDYGNDDLRDN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 185 KKIATLPADFYSTKNYTDTLIHYIDKNKGDqKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSGWDSLRvlrlnnlkalg 264
Cdd:cd16029 152 EEPAWDYNGTYSTDLFTDRAVDIIENHDPS-KPLFLYLAFQAVHAPLQVPPEYADPYEDKFAHIKDEDR----------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 265 iisadvnsfapsgipqwstlspeqkaefakdmEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvmATTY 344
Cdd:cd16029 220 --------------------------------RTYAAMVSALDESVGNVVDALKAKGMLDNTLIVFTSDNG-----GPTG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 345 PGnadgkylgafnneldnrglpnsfvemgpgwAQASSSPFRLFKSFASEGGIRAPLMIKLPNAAPSPGQWNKSFVHVTDL 424
Cdd:cd16029 263 GG------------------------------DGGSNYPLRGGKNTLWEGGVRVPAFVWSPLLPPKRGTVSDGLMHVTDW 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 425 MPTVLQLAEVSYPAqfkekavRQPI-GKSLLPVLTGTAQEVHAD---GAGMGWELFERKAYIKGKWKVLrlpapfsTGEw 500
Cdd:cd16029 313 LPTLLSLAGGDPDD-------LPPLdGVDQWDALSGGAPSPRTEillNIDDITRTTGGAAIRVGDWKLI-------VGK- 377
|
490
....*....|....*.
gi 472840594 501 QLFDLEKDPGEANDLS 516
Cdd:cd16029 378 PLFNIENDPCERNDLA 393
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-516 |
1.13e-69 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 229.40 E-value: 1.13e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGN--INTPVLDQFSKEGMLFSNFYVlP--TCSPTRSALLTGNDNHVagvgimsevSYPAV 103
Cdd:cd16143 1 PNIVIILADDLGYGDISCYNPDskIPTPNIDRLAAEGMRFTDAHS-PssVCTPSRYGLLTGRYPWR---------SRLKG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 104 ANLPGYSGHL-NNQVVTIPELLRESGYHTYMAGKWHLG-------------------DDEGQI---PSDRGFEESFALLQ 160
Cdd:cd16143 71 GVLGGFSPPLiEPDRVTLAKMLKQAGYRTAMVGKWHLGldwkkkdgkkaatgtgkdvDYSKPIkggPLDHGFDYYFGIPA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 161 GggshyadqkplsppQVMDyrvngkkiaTLpadfystknyTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEyidk 240
Cdd:cd16143 151 S--------------EVLP---------TL----------TDKAVEFIDQHAKKDKPFFLYFALPAPHTPIVPSPE---- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 241 YKGKfdsgwdslrvlrlnnlkalgiisadvnsfapsgipqwSTLSPeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQ 320
Cdd:cd16143 194 FQGK-------------------------------------SGAGP------------YGDFVYELDWVVGRILDALKEL 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 321 GLYDNTMIVFMSDNGANgvmattypgnadgkyLGAFNNELDNRGlpnsfvemgpgwaQASSSPFRLFKSFASEGGIRAPL 400
Cdd:cd16143 225 GLAENTLVIFTSDNGPS---------------PYADYKELEKFG-------------HDPSGPLRGMKADIYEGGHRVPF 276
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 401 MIKLPNAAPsPGQWNKSFVHVTDLMPTVLQLAEVSYPAQfkekavRQPIGKSLLPVLTGTAQE------VHADGAGmgwe 474
Cdd:cd16143 277 IVRWPGKIP-AGSVSDQLVSLTDLFATLAAIVGQKLPDN------AAEDSFSFLPALLGPKKQevreslVHHSGNG---- 345
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 472840594 475 lfeRKAYIKGKWKVLRlpAPFSTGEW-------------QLFDLEKDPGEANDLS 516
Cdd:cd16143 346 ---SFAIRKGDWKLID--GTGSGGFSyprgkeklglppgQLYNLSTDPGESNNLY 395
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
26-515 |
4.88e-68 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 226.26 E-value: 4.88e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 26 QRPNILFIVADDLGFSDIGPFGGNIN-TPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVGIMSEVSYPAV 103
Cdd:cd16031 1 KRPNIIFILTDDHRYDALGCYGNPIVkTPNIDRLAKEGVRFDNAFVtTSICAPSRASILTGQYSHRHGVTDNNGPLFDAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 104 AnlpgysghlnnqvVTIPELLRESGYHTYMAGKWHLGDDEGQIPsdRGFEEsFALLQGGGSHYADqkplsppqvmDYRVN 183
Cdd:cd16031 81 Q-------------PTYPKLLRKAGYQTAFIGKWHLGSGGDLPP--PGFDY-WVSFPGQGSYYDP----------EFIEN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 184 GKKIATLPadfYSTKNYTDTLIHYIDKNKGDqKPFFIYASYTAPHDPLQAPKEYIDKYKGK--------FDSGWDSL-RV 254
Cdd:cd16031 135 GKRVGQKG---YVTDIITDKALDFLKERDKD-KPFCLSLSFKAPHRPFTPAPRHRGLYEDVtipepetfDDDDYAGRpEW 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 255 LRlnnlKALGIIsadvnsfapSGIPQWSTLSPEQKAEFAKDmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDN 334
Cdd:cd16031 211 AR----EQRNRI---------RGVLDGRFDTPEKYQRYMKD---YLRTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDN 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 335 GangvmattYpgnadgkYLGafnneldNRGLpnsfveMGpgwaqassspfrlfKSFASEGGIRAPLMIKLPNAAPsPGQW 414
Cdd:cd16031 275 G--------F-------FLG-------EHGL------FD--------------KRLMYEESIRVPLIIRDPRLIK-AGTV 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 415 NKSFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQEVHADGAGMgwELFERKAY--------IKGK- 485
Cdd:cd16031 312 VDALVLNIDFAPTILDLAGVPIPEDMQ--------GRSLLPLLEGEKPVDWRKEFYY--EYYEEPNFhnvpthegVRTEr 381
|
490 500 510
....*....|....*....|....*....|
gi 472840594 486 WKVLRLPAPfsTGEWQLFDLEKDPGEANDL 515
Cdd:cd16031 382 YKYIYYYGV--WDEEELYDLKKDPLELNNL 409
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
28-532 |
5.73e-68 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 224.31 E-value: 5.73e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNINTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGndnhvagvgimsevSYPA---V 103
Cdd:cd16027 1 PNILWIIADDLSPDLGGYGGNVVKTPNLDRLAAEGVRFTNAFTtAPVCSPSRSALLTG--------------LYPHqngA 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 104 ANLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEgqipsDRGFEESFallqgggshyadqkplsppqvmdyrvn 183
Cdd:cd16027 67 HGLRSRGFPLPDGVKTLPELLREAGYYTGLIGKTHYNPDA-----VFPFDDEM--------------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 184 gkkiATLPADFYSTKNYTDTLIHYIDKNKGDQkPFFIYASYTAPHDPlqapkeYIDKYKGKFDSGWDSLRVlrlnnlkal 263
Cdd:cd16027 115 ----RGPDDGGRNAWDYASNAADFLNRAKKGQ-PFFLWFGFHDPHRP------YPPGDGEEPGYDPEKVKV--------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 264 giisadvnsfaPSGIPQwstlSPEQKAEFAKdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvmatt 343
Cdd:cd16027 175 -----------PPYLPD----TPEVREDLAD----YYDEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHG-------- 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 344 ypgnadgkylgafnneldnRGLPNSfvemgpgwaqassspfrlfKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTD 423
Cdd:cd16027 228 -------------------MPFPRA-------------------KGTLYDSGLRVPLIVRWPGKIK-PGSVSDALVSFID 268
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 424 LMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQE----VHADGAGMGWELFERKAYIKGKWKVLRLPAPfstge 499
Cdd:cd16027 269 LAPTLLDLAGIEPPEYLQ--------GRSFLPLLKGEKDPgrdyVFAERDRHDETYDPIRSVRTGRYKYIRNYMP----- 335
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 472840594 500 WQLFDLEKDPGEANDLSQQfPA-------LRDSLvNEWLK 532
Cdd:cd16027 336 EELYDLKNDPDELNNLADD-PEyaevleeLRAAL-DAWMK 373
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
26-526 |
2.87e-67 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 222.44 E-value: 2.87e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 26 QRPNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGMLFSNFYVL-----PTCSPTRSALLTGndnhvagvgiMSEVS 99
Cdd:cd16155 1 KKPNILFILADDQRADTIGALGNPeIQTPNLDRLARRGTSFTNAYNMggwsgAVCVPSRAMLMTG----------RTLFH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 100 YPAVANLPgysghLNNQVVTIPELLRESGYHTYMAGKWHLGddegqipsdrgfeesfallqgggshyadqkplsppqvmd 179
Cdd:cd16155 71 APEGGKAA-----IPSDDKTWPETFKKAGYRTFATGKWHNG--------------------------------------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 180 yrvngkkiatlpadfystknYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYKGK-------------FD 246
Cdd:cd16155 107 --------------------FADAAIEFLEEYKDGDKPFFMYVAFTAPHDPRQAPPEYLDMYPPEtiplpenflpqhpFD 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 247 SGWDSLRvlrlnnlkalgiisaDVNsFAPsgipqwstlSPEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNT 326
Cdd:cd16155 167 NGEGTVR---------------DEQ-LAP---------FPRTPEAVRQHLAEYYAMITHLDAQIGRILDALEASGELDNT 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 327 MIVFMSDNGangvMAttypgnadgkyLGafnneldNRGLpnsfveMGpgwaqassspfrlfKSFASEGGIRAPLMIKLPN 406
Cdd:cd16155 222 IIVFTSDHG----LA-----------VG-------SHGL------MG--------------KQNLYEHSMRVPLIISGPG 259
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 407 AApsPGQWNKSFVHVTDLMPTVLQLAEVSYPaqfkeKAVRqpiGKSLLPVLTGTAQEVHAD--GAGMGWelfeRKAYIKG 484
Cdd:cd16155 260 IP--KGKRRDALVYLQDVFPTLCELAGIEIP-----ESVE---GKSLLPVIRGEKKAVRDTlyGAYRDG----QRAIRDD 325
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 472840594 485 KWKVLRLPApfSTGEWQLFDLEKDPGEANDLSQQfPALRDSL 526
Cdd:cd16155 326 RWKLIIYVP--GVKRTQLFDLKKDPDELNNLADE-PEYQERL 364
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-515 |
5.75e-64 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 213.62 E-value: 5.75e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGMLFSNFYVLPTCSPTRSALLTGNDNHVAGVgimsevsypavanl 106
Cdd:cd16151 1 PNIILIMADDLGYECIGCYGGEsYKTPNIDALAAEGVRFNNAYAQPLCTPSRVQLMTGKYNFRNYV-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 107 pgYSGHLNNQVVTIPELLRESGYHTYMAGKWHLG--DDEGQIPSDRGFEEsFALLQGggsHYADQKPLSPPQVMDYRVNG 184
Cdd:cd16151 67 --VFGYLDPKQKTFGHLLKDAGYATAIAGKWQLGggRGDGDYPHEFGFDE-YCLWQL---TETGEKYSRPATPTFNIRNG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 185 KKIATLPADfYSTKNYTDTLIHYIDKNKgdQKPFFIYASYTAPHDPlqapkeyidkykgkFDSGWDSlrvlrlnnlkalg 264
Cdd:cd16151 141 KLLETTEGD-YGPDLFADFLIDFIERNK--DQPFFAYYPMVLVHDP--------------FVPTPDS------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 265 iisadvnsfapsgiPQWSTLSPeqkaEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANGVMATTY 344
Cdd:cd16151 191 --------------PDWDPDDK----RKKDDPEYFPDMVAYMDKLVGKLVDKLEELGLRENTIIIFTGDNGTHRPITSRT 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 345 PGnadGKYLGAfnneldnrglpnsfvemgpgwaqassspfrlfKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTDL 424
Cdd:cd16151 253 NG---REVRGG--------------------------------KGKTTDAGTHVPLIVNWPGLIP-AGGVSDDLVDFSDF 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 425 MPTVLQLAEVSYPAQFkekavrqPI-GKSLLPVLTGTAQEVHadgagmgWELFerKAYIKGKWKVLRlPAPFSTGEW--- 500
Cdd:cd16151 297 LPTLAELAGAPLPEDY-------PLdGRSFAPQLLGKTGSPR-------REWI--YWYYRNPHKKFG-SRFVRTKRYkly 359
|
490
....*....|....*...
gi 472840594 501 ---QLFDLEKDPGEANDL 515
Cdd:cd16151 360 adgRFFDLREDPLEKNPL 377
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
27-515 |
1.47e-63 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 213.20 E-value: 1.47e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFGG-NINTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGndnhvagvgimsevSYPAVA 104
Cdd:cd16034 1 KPNILFIFADQHRAQALGCAGDdPVKTPNLDRLAKEGVVFTNAVsNYPVCSPYRASLLTG--------------QYPLTN 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEG--------QIPSDR--GFEESFALLQGGG---SHYadqkp 171
Cdd:cd16034 67 GVFGNDVPLPPDAPTIADVLKDAGYRTGYIGKWHLDGPERndgraddyTPPPERrhGFDYWKGYECNHDhnnPHY----- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 172 lsppqvmdYRVNGKKIATlpaDFYSTKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDP-LQAPKEYIDKYKgkfdsgwD 250
Cdd:cd16034 142 --------YDDDGKRIYI---KGYSPDAETDLAIEYLENQADKDKPFALVLSWNPPHDPyTTAPEEYLDMYD-------P 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 251 SLRVLRLNnlkalgiisadvnsfapsgIPqwstLSPEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVF 330
Cdd:cd16034 204 KKLLLRPN-------------------VP----EDKKEEAGLREDLRGYYAMITALDDNIGRLLDALKELGLLENTIVVF 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 331 MSDNG----ANGVMATTYPgnadgkYlgafnneldnrglpnsfvemgpgwaqassspfrlfksfasEGGIRAPLMIKLPN 406
Cdd:cd16034 261 TSDHGdmlgSHGLMNKQVP------Y----------------------------------------EESIRVPFIIRYPG 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 407 AAPSPGQWNKSFVHVtDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGT---------AQEVHADGAGMGWELFE 477
Cdd:cd16034 295 KIKAGRVVDLLINTV-DIMPTLLGLCGLPIPDTVE--------GRDLSPLLLGGkddepdsvlLQCFVPFGGGSARDGGE 365
|
490 500 510
....*....|....*....|....*....|....*...
gi 472840594 478 RKAYIKGKWKVLRlpapFSTGEWQLFDLEKDPGEANDL 515
Cdd:cd16034 366 WRGVRTDRYTYVR----DKNGPWLLFDNEKDPYQLNNL 399
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
28-440 |
6.39e-63 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 206.13 E-value: 6.39e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVGimsevsypavaN 105
Cdd:cd16022 1 PNILLIMTDDLGYDDLGCYGNPdIKTPNLDRLAAEGVRFTNAYVaSPVCSPSRASLLTGRYPHRHGVR-----------G 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHlgddegqipsdrgfEESfallqgggshyadqkplsppqvmdyrvngk 185
Cdd:cd16022 70 NVGNGGGLPPDEPTLAELLKEAGYRTALIGKWH--------------DEA------------------------------ 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatlpadfystknytdtlIHYIDKNKGDqKPFFIYASYTAPHDPLqapkeyidkykgkfdsgwdslrvlrlnnlkalgi 265
Cdd:cd16022 106 -------------------IDFIERRDKD-KPFFLYVSFNAPHPPF---------------------------------- 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 266 isadvnsfapsgipqwstlspeqkaefakdmeVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGAngvmattyp 345
Cdd:cd16022 132 --------------------------------AYYAMVSAIDDQIGRILDALEELGLLDNTLIVFTSDHGD--------- 170
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 346 gnadgkYLGAFNNeldnrglpnsfvemgpgwaqassspfRLFKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTDLM 425
Cdd:cd16022 171 ------MLGDHGL--------------------------RGKKGSLYEGGIRVPFIVRWPGKIP-AGQVSDALVSLLDLL 217
|
410
....*....|....*
gi 472840594 426 PTVLQLAEVSYPAQF 440
Cdd:cd16022 218 PTLLDLAGIEPPEGL 232
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
28-515 |
1.31e-62 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 210.08 E-value: 1.31e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNIN----TPVLDQFSKEGMLFSNFYVLPTCSPTRSALLTGNdnHVAGVGiMSEVSypav 103
Cdd:cd16142 1 PNILVILGDDIGWGDLGCYGGGIGrgapTPNIDRLAKEGLRFTSFYVEPSCTPGRAAFITGR--HPIRTG-LTTVG---- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 104 anLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFallqGGGSHYADqkplsppqvmdyrvn 183
Cdd:cd16142 74 --LPGSPGGLPPWEPTLAELLKDAGYATAQFGKWHLGDEDGRLPTDHGFDEFY----GNLYHTID--------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 184 gkkiatlpadfystKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDP-LQAPkeyidKYKGKfdsgwdslrvlrlnnlka 262
Cdd:cd16142 133 --------------EEIVDKAIDFIKRNAKADKPFFLYVNFTKMHFPtLPSP-----EFEGK------------------ 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 263 lgiiSADVNSFApsgipqwstlspeqkaefakdmevyAAMVEyLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGAngvMAT 342
Cdd:cd16142 176 ----SSGKGKYA-------------------------DSMVE-LDDHVGQILDALDELGIADNTIVIFTTDNGP---EQD 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 343 TYPGnadgkylgafnneldnrglpnsfvemgpgwaqASSSPFRLFKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVT 422
Cdd:cd16142 223 VWPD--------------------------------GGYTPFRGEKGTTWEGGVRVPAIVRWPGKIK-PGRVSNEIVSHL 269
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 423 DLMPTVLQLAEVSYPAQFKEKAVRQPIGKSLLPVLTGTaQEVHADGAGMGWELFERKAYIKGKWKVL---------RLPA 493
Cdd:cd16142 270 DWFPTLAALAGAPDPKDKLLGKDRHIDGVDQSPFLLGK-SEKSRRSEFFYFGEGELGAVRWKNWKVHfkaqedtggPTGE 348
|
490 500
....*....|....*....|...
gi 472840594 494 PFSTGEW-QLFDLEKDPGEANDL 515
Cdd:cd16142 349 PFYVLTFpLIFNLRRDPKERYDV 371
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-515 |
6.91e-59 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 201.30 E-value: 6.91e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNI-NTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGNDNHVAGVgimsevsYPAVAN 105
Cdd:cd16033 1 PNILFIMTDQQRYDTLGCYGNPIvKTPNIDRLAAEGVRFTNAYtPSPVCCPARASLLTGLYPHEHGV-------LNNVEN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGqiPSDRGFEEsfallqgggshYADQKPlsppqVMDYRVngk 185
Cdd:cd16033 74 AGAYSRGLPPGVETFSEDLREAGYRNGYVGKWHVGPEET--PLDYGFDE-----------YLPVET-----TIEYFL--- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatlpadfystknyTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYKGK--------FDSGWDSLRVLRL 257
Cdd:cd16033 133 ---------------ADRAIEMLEELAADDKPFFLRVNFWGPHDPYIPPEPYLDMYDPEdiplpesfADDFEDKPYIYRR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 258 NNLKalgiisadvnsfapsgipqWSTLSpEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNgan 337
Cdd:cd16033 198 ERKR-------------------WGVDT-EDEEDWKEIIAHYWGYITLIDDAIGRILDALEELGLADDTLVIFTSDH--- 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 338 gvmattypgnadGKYLGAFNneLDNRGLPnSFVEMgpgwaqassspfrlfksfaseggIRAPLMIKLPNAAPsPGQWNKS 417
Cdd:cd16033 255 ------------GDALGAHR--LWDKGPF-MYEET-----------------------YRIPLIIKWPGVIA-AGQVVDE 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 418 FVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTA-----QEVHADGAGMGWELFERkAYIKGKWK-VLRl 491
Cdd:cd16033 296 FVSLLDLAPTILDLAGVDVPPKVD--------GRSLLPLLRGEQpedwrDEVVTEYNGHEFYLPQR-MVRTDRYKyVFN- 365
|
490 500
....*....|....*....|....
gi 472840594 492 paPFSTGEwqLFDLEKDPGEANDL 515
Cdd:cd16033 366 --GFDIDE--LYDLESDPYELNNL 385
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
28-432 |
6.43e-52 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 179.54 E-value: 6.43e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNI-NTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVGIMSEVSypavan 105
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRpTTPFLDRLAEEGLLFSNFYSgGTLTAPSRFALLTGLPPHNFGSYVSTPVG------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 lpgysghLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFALLqgGGSHYADQKPLSPPQvmdyrvngk 185
Cdd:pfam00884 75 -------LPRTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQSPCNLGFDKFFGRN--TGSDLYADPPDVPYN--------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatLPADFYSTKNYTDTLIHYIDKNkgdQKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSGwdslrvlrlnnlkalgi 265
Cdd:pfam00884 137 ----CSGGGVSDEALLDEALEFLDNN---DKPFFLVLHTLGSHGPPYYPDRYPEKYATFKPSS----------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 266 isadvnsfapsgipqwstlspeqkAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvmATTYP 345
Cdd:pfam00884 193 ------------------------CSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHG-----ESLGE 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 346 GNADGKYLGAFNneldnrglpnsfvemgpgwaqassspfrlfksfASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTDLM 425
Cdd:pfam00884 244 GGGYLHGGKYDN---------------------------------APEGGYRVPLLIWSPGGKA-KGQKSEALVSHVDLF 289
|
....*..
gi 472840594 426 PTVLQLA 432
Cdd:pfam00884 290 PTILDLA 296
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
26-517 |
4.17e-47 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 170.45 E-value: 4.17e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 26 QRPNILFIVADDLGfSDIGPFGGN-INTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGndnhvagvgimsevSYPA- 102
Cdd:cd16030 1 KKPNVLFIAVDDLR-PWLGCYGGHpAKTPNIDRLAARGVLFTNAYCqQPVCGPSRASLLTG--------------RRPDt 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 103 --VANLPGYSGHLNNQVVTIPELLRESGYHTYMAGK-WHLGDDEGQipsDRGFEESFALLQGGGSHYADQKPLSPPQVMD 179
Cdd:cd16030 66 tgVYDNNSYFRKVAPDAVTLPQYFKENGYTTAGVGKiFHPGIPDGD---DDPASWDEPPNPPGPEKYPPGKLCPGKKGGK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 180 YRVNGKKIATLPADfysTKNYTDTL-----IHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKY---KGKFDSGWDS 251
Cdd:cd16030 143 GGGGGPAWEAADVP---DEAYPDGKvadeaIEQLRKLKDSDKPFFLAVGFYKPHLPFVAPKKYFDLYpleSIPLPNPFDP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 252 LRV--LRLNNLkalgiisADVNSFAPSGIPQWSTLSPEQKAEFAKDMeV--YAAMVEYLDMSIGRLLDYLKQQGLYDNTM 327
Cdd:cd16030 220 IDLpeVAWNDL-------DDLPKYGDIPALNPGDPKGPLPDEQAREL-RqaYYASVSYVDAQVGRVLDALEELGLADNTI 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 328 IVFMSDNGANgvmattypgnadgkyLGafnneldnrglpnsfvEMGpGWAQASsspfrLFksfasEGGIRAPLMIKLPNa 407
Cdd:cd16030 292 VVLWSDHGWH---------------LG----------------EHG-HWGKHT-----LF-----EEATRVPLIIRAPG- 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 408 APSPGQWNKSFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQEV-------HADGAGMGWEL-FERK 479
Cdd:cd16030 329 VTKPGKVTDALVELVDIYPTLAELAGLPAPPCLE--------GKSLVPLLKNPSAKWkdaafsqYPRPSIMGYSIrTERY 400
|
490 500 510
....*....|....*....|....*....|....*...
gi 472840594 480 AYIkgKWKvlrlPAPFSTGEwQLFDLEKDPGEANDLSQ 517
Cdd:cd16030 401 RYT--EWV----DFDKVGAE-ELYDHKNDPNEWKNLAN 431
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
28-516 |
6.08e-46 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 167.44 E-value: 6.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFsDIGPFGGN--INTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGndnhvagvgiMSEVSYPAVA 104
Cdd:cd16028 1 RNVLFITADQWRA-DCLSCLGHplVKTPNLDRLAAEGVRFRNHYTqAAPCGPSRASLYTG----------RYLMNHRSVW 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 N-LPGYSGHLNnqvvtIPELLRESGYHTYMAGKWHLG-DDEGQIPSDRGFEeSFALLQGGGSHYAdqkplsppQVMDYrv 182
Cdd:cd16028 70 NgTPLDARHLT-----LALELRKAGYDPALFGYTDTSpDPRGLAPLDPRLL-SYELAMPGFDPVD--------RLDEY-- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 183 ngkkiatlPADFYSTKNYTDTLIHYIDKnkGDQKPFFIYASYTAPHDPLQAPKEYIDKYKgkfdsgWDSL-RVLRLNNLK 261
Cdd:cd16028 134 --------PAEDSDTAFLTDRAIEYLDE--RQDEPWFLHLSYIRPHPPFVAPAPYHALYD------PADVpPPIRAESLA 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 262 ALGII---------SADVNSFAPSGIPQwSTLSPEQKAEFAKdmeVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMS 332
Cdd:cd16028 198 AEAAQhpllaafleRIESLSFSPGAANA-ADLDDEEVAQMRA---TYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTS 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 333 DNGangvmattypgnadgkylgafnneldnrglpnsfvEM-GPGWaqassspfrLF-KSFASEGGIRAPLMIKLP--NAA 408
Cdd:cd16028 274 DHG-----------------------------------EQlGDHW---------LWgKDGFFDQAYRVPLIVRDPrrEAD 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 409 PSPGQWNKSFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTA-----QEVH-----ADGAGMGWELFE- 477
Cdd:cd16028 310 ATRGQVVDAFTESVDVMPTILDWLGGEIPHQCD--------GRSLLPLLAGAQpsdwrDAVHyeydfRDVSTRRPQEALg 381
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 472840594 478 ------RKAYIK-GKWKVLRLPA--PfstgewQLFDLEKDPGEANDLS 516
Cdd:cd16028 382 lspdecSLAVIRdERWKYVHFAAlpP------LLFDLKNDPGELRDLA 423
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
25-532 |
8.37e-44 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 162.53 E-value: 8.37e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 25 PQRPNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGndnhvagvgiMSevsyPA 102
Cdd:PRK13759 4 TKKPNIILIMVDQMRGDCLGCNGNKaVETPNLDMLASEGYNFENAYsAVPSCTPARAALLTG----------LS----QW 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 103 VANLPGYSGHLN-NQVVTIPELLRESGYHTYMAGKWHLGDDEGQIpsdrGFEEsfALLQGGGSHYADQK-PLSPPQVMDY 180
Cdd:PRK13759 70 HHGRVGYGDVVPwNYKNTLPQEFRDAGYYTQCIGKMHVFPQRNLL----GFHN--VLLHDGYLHSGRNEdKSQFDFVSDY 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 181 R------VNGK----------------KIATLPADFYSTKNYTDTLIHYIdKNKGDQKPFFIYASYTAPHDPLQAPKEYI 238
Cdd:PRK13759 144 LawlrekAPGKdpdltdigwdcnswvaRPWDLEERLHPTNWVGSESIEFL-RRRDPTKPFFLKMSFARPHSPYDPPKRYF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 239 DKYK---------GKFDSGWDSlrvlrlnnlkalgiISADVNSFAPSGipqwsTLSPEQkaefAKDMEV-YAAMVEYLDM 308
Cdd:PRK13759 223 DMYKdadipdphiGDWEYAEDQ--------------DPEGGSIDALRG-----NLGEEY----ARRARAaYYGLITHIDH 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 309 SIGRLLDYLKQQGLYDNTMIVFMSDNgangvmattypgnadGKYLGAFNNeldnrglpnsfvemgpgwaqassspFRlfK 388
Cdd:PRK13759 280 QIGRFLQALKEFGLLDNTIILFVSDH---------------GDMLGDHYL-------------------------FR--K 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 389 SFASEGGIRAPLMIKLPNAAPSP--GQWNKSFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQEV-- 464
Cdd:PRK13759 318 GYPYEGSAHIPFIIYDPGGLLAGnrGTVIDQVVELRDIMPTLLDLAGGTIPDDVD--------GRSLKNLIFGQYEGWrp 389
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 472840594 465 HADGAGMGWElfERKAYI-KGKWKVLRLpapFSTGEWQLFDLEKDPGEANDLSQQfPALRDSLVnEWLK 532
Cdd:PRK13759 390 YLHGEHALGY--SSDNYLtDGKWKYIWF---SQTGEEQLFDLKKDPHELHNLSPS-EKYQPRLR-EMRK 451
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-511 |
8.71e-44 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 159.82 E-value: 8.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFsDIGP---FGGNI-NTPVLDQFSKEGMLFSNFYVLPTCSPTRSALLTG---NDNHVAGVGimsevsy 100
Cdd:cd16154 1 PNILLIIADDQGL-DSSAqysLSSDLpVTPTLDSLANSGIVFDNLWATPACSPTRATILTGkygFRTGVLAVP------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 101 pavanlpgysGHLNNQVVTIPELLRES----GYHTYMAGKWHLGDDEGQIPSDRGFEESFALLQGGGSHYADQkPLSppq 176
Cdd:cd16154 73 ----------DELLLSEETLLQLLIKDattaGYSSAVIGKWHLGGNDNSPNNPGGIPYYAGILGGGVQDYYNW-NLT--- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 177 vmdyrVNGKkiaTLPADFYSTKNYTDTLIHYIDKNkgdQKPFFIYASYTAPHDPLQAPkeyidkykgkfdsgwdslrvlr 256
Cdd:cd16154 139 -----NNGQ---TTNSTEYATTKLTNLAIDWIDQQ---TKPWFLWLAYNAPHTPFHLP---------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 257 lnnlkalgiiSADVNSfapsgipqwSTLSPEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLyDNTMIVFMSDNGA 336
Cdd:cd16154 186 ----------PAELHS---------RSLLGDSADIEANPRPYYLAAIEAMDTEIGRLLASIDEEER-ENTIIIFIGDNGT 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 337 ngvmattyPGNAdgkylgafNNELDNRGlpnsfvemgpgwaQASSSpfrlfksfASEGGIRAPLMIklpnAAPSPGQWNK 416
Cdd:cd16154 246 --------PGQV--------VDLPYTRN-------------HAKGS--------LYEGGINVPLIV----SGAGVERANE 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 417 ---SFVHVTDLMPTVLQLAEVSYPAQFKEkavrqpigKSLLPVLTGTAQEVHA------DGAGMGWELFERKAYikgKWK 487
Cdd:cd16154 285 resALVNATDLYATIAELAGVDAAEIHDS--------VSFKPLLSDVNASTRQynyteyESPTTTGWATRNQYY---KLI 353
|
490 500
....*....|....*....|....
gi 472840594 488 VlrlpapFSTGEWQLFDLEKDPGE 511
Cdd:cd16154 354 E------SENGQEELYDLINDPSE 371
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
27-512 |
1.07e-42 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 156.86 E-value: 1.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFG--GNINTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGNDNHVAGVGimSEVSYPAV 103
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWapNAILTPNLDKLAAEGTRFVDWYsAASVCSPSRASLMTGRLGLRNGVG--HNFLPTSV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 104 ANLPgysghLNNqvVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFALLQGGGSHYADqkplsppqvmdyrvn 183
Cdd:cd16161 79 GGLP-----LNE--TTLAEVLRQAGYATGMIGKWHLGQREAYLPNSRGFDYYFGIPFSHDSSLAD--------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 184 gkKIATLPADFystknytdtlihyIDKNKGDQKPFFIYASYTAPHDPLQAPKEYidkykgkfdsgwdslrvlrlnnlkal 263
Cdd:cd16161 137 --RYAQFATDF-------------IQRASAKDRPFFLYAALAHVHVPLANLPRF-------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 264 giisadVNSFAPSGIpqwstlspeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANGVMATT 343
Cdd:cd16161 176 ------QSPTSGRGP--------------------YGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGPWEVKCEL 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 344 YPGNADGKYLGAfnneldnrglpnsfvemGPGwaqassspfRLFKSFASEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTD 423
Cdd:cd16161 230 AVGPGTGDWQGN-----------------LGG---------SVAKASTWEGGHREPAIVYWPGRIP-ANSTSAALVSTLD 282
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 424 LMPTVLQLAEVSYPAQfkekavRQPIGKSLLPVLTGTAQEVH------ADGAGMGWELferKAYIKGKWKVL-----RLP 492
Cdd:cd16161 283 IFPTVVALAGASLPPG------RIYDGKDLSPVLFGGSKTGHrclfhpNSGAAGAGAL---SAVRCGDYKAHyatggALA 353
|
490 500
....*....|....*....|....*.
gi 472840594 493 APFSTGEWQ------LFDLEKDPGEA 512
Cdd:cd16161 354 CCGSTGPKLyhdpplLFDLEVDPAES 379
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-455 |
6.98e-42 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 151.24 E-value: 6.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFG-GNINTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGN--DNHvagvGIMSEVSYPAV 103
Cdd:cd16149 1 PNILFILTDDQGPWALGCYGnSEAVTPNLDRLAAEGVRFENFFcTSPVCSPARASLLTGRmpSQH----GIHDWIVEGSH 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 104 ANLPGYSGHLNNQVvTIPELLRESGYHTYMAGKWHLGDDEgqipsdrgfeesfallqgggshyadqkplsppqvmdyrvn 183
Cdd:cd16149 77 GKTKKPEGYLEGQT-TLPEVLQDAGYRCGLSGKWHLGDDA---------------------------------------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 184 gkkiatlpADFystknytdtlihyIDKNKGDQKPFFIYASYTAPHDPLQapkeyidkykgkfdsgwdslrvlrlnnlkal 263
Cdd:cd16149 116 --------ADF-------------LRRRAEAEKPFFLSVNYTAPHSPWG------------------------------- 143
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 264 giisadvnsfapsgipqwstlspeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGAN----GV 339
Cdd:cd16149 144 -----------------------------------YFAAVTGVDRNVGRLLDELEELGLTENTLVIFTSDNGFNmghhGI 188
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 340 MATtypGNAdgkylgafnneldnrglpnsfvemgpgwaqasSSPFRLFksfasEGGIRAPLMIKLPNAAPsPGQWNKSFV 419
Cdd:cd16149 189 WGK---GNG--------------------------------TFPLNMY-----DNSVKVPFIIRWPGVVP-AGRVVDSLV 227
|
410 420 430
....*....|....*....|....*....|....*.
gi 472840594 420 HVTDLMPTVLQLAEVSYPAqfkekAVRQPiGKSLLP 455
Cdd:cd16149 228 SAYDFFPTLLELAGVDPPA-----DPRLP-GRSFAD 257
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
27-457 |
2.20e-40 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 152.62 E-value: 2.20e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFGG-NINTPVLDQFSKEGMLFSNFYVL-PTCSPTRSALLTGN---DNhvagvGIMSEVSYP 101
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFGEpSRETPNLDRMAAEGMLFTDFYSAnPLCSPSRAALLTGRlpiRN-----GFYTTNAHA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 102 AVANLPGY-SGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIPSDRGFEESFALLQGGGSHYADQKPLSPPQVMDY 180
Cdd:cd16157 76 RNAYTPQNiVGGIPDSEILLPELLKKAGYRNKIVGKWHLGHRPQYHPLKHGFDEWFGAPNCHFGPYDNKAYPNIPVYRDW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 181 RVNGKKIATLPADFYS-----TKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKeyidKYKGKFDSGwdslrvl 255
Cdd:cd16157 156 EMIGRYYEEFKIDKKTgesnlTQIYLQEALEFIEKQHDAQKPFFLYWAPDATHAPVYASK----PFLGTSQRG------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 256 rlnnlkalgiisadvnsfapsgipqwstlspeqkaefakdmeVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNG 335
Cdd:cd16157 225 ------------------------------------------LYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 336 ANGVMATTYPGnadgkylgafnneldnrglpnsfvemgpgwaqaSSSPFRLFKSFASEGGIRAPLMIKLPNAAPsPGQWN 415
Cdd:cd16157 263 AALISAPEQGG---------------------------------SNGPFLCGKQTTFEGGMREPAIAWWPGHIK-PGQVS 308
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 472840594 416 KSFVHVTDLMPTVLQLAEVSYPAQfkekavRQPIGKSLLPVL 457
Cdd:cd16157 309 HQLGSLMDLFTTSLALAGLPIPSD------RAIDGIDLLPVL 344
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
28-546 |
3.13e-40 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 152.15 E-value: 3.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGG-NINTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGNDNHVAGvgimsevsypAVAN 105
Cdd:cd16156 1 KQFIFIMTDTQRWDMVGCYGNkAMKTPNLDRLAAEGVRFDSAYtTQPVCGPARSGLFTGLYPHTNG----------SWTN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 -LPgysghLNNQVVTIPELLRESGYHTYMAGKWHL--GDDEGQIPSDRGFEESFALlqgGGSHYADQ-------KPLSPP 175
Cdd:cd16156 71 cMA-----LGDNVKTIGQRLSDNGIHTAYIGKWHLdgGDYFGNGICPQGWDPDYWY---DMRNYLDElteeerrKSRRGL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 176 QVMDYRvngkkiaTLPADFYSTKNYTDTLIHYIDKNKgdQKPFFIYASYTAPHDPLQAPKEYIDKYKG-KFDSG---WDS 251
Cdd:cd16156 143 TSLEAE-------GIKEEFTYGHRCTNRALDFIEKHK--DEDFFLVVSYDEPHHPFLCPKPYASMYKDfEFPKGenaYDD 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 252 LRVLrlnnlkalgiisadvnsfaPSGIPQWS-TLSPEQKAEFAKDMEVYAAMVEYLDMSIGRLLDYLKQqgLYDNTMIVF 330
Cdd:cd16156 214 LENK-------------------PLHQRLWAgAKPHEDGDKGTIKHPLYFGCNSFVDYEIGRVLDAADE--IAEDAWVIY 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 331 MSDNgangvmattypgnadGKYLGAfnneldnrglpNSFVEMGPGwaqassspfrlfksfASEGGIRAPLMIKLPNAAPS 410
Cdd:cd16156 273 TSDH---------------GDMLGA-----------HKLWAKGPA---------------VYDEITNIPLIIRGKGGEKA 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 411 PGQWNKSFVHVtDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTG-------------TAQEVHADGAGmGWELFe 477
Cdd:cd16156 312 GTVTDTPVSHI-DLAPTILDYAGIPQPKVLE--------GESILATIEDpeipenrgvfvefGRYEVDHDGFG-GFQPV- 380
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 472840594 478 rKAYIKGKWK-VLRLpapFSTGEwqLFDLEKDPGEANDL--SQQFPALRDSLVNEWLKYA-KANDVFdhRGHY 546
Cdd:cd16156 381 -RCVVDGRYKlVINL---LSTDE--LYDLEKDPYEMHNLidDPDYADVRDQLHDELLDYMnETRDPF--RGYY 445
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-510 |
5.04e-38 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 142.30 E-value: 5.04e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGfSDIGPFGGN--INTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGndNHVAGVGIMSevsypava 104
Cdd:cd16037 1 PNILIIMSDEHN-PDAMGCYGHpvVRTPNLDRLAARGTRFENAYTpSPICVPSRASFLTG--RYVHETGVWD-------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGhlnnQVVTIPELLRESGYHTYMAGKWHLGDDEgqipsdrgfeesfallQGGGSHYadqkplsppqvmdyrvng 184
Cdd:cd16037 70 NADPYDG----DVPSWGHALRAAGYETVLIGKLHFRGED----------------QRHGFRY------------------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 185 kkiatlpadfysTKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYkgkfdsgwdslrvlrlnnlkALG 264
Cdd:cd16037 112 ------------DRDVTEAAVDWLREEAADDKPWFLFVGFVAPHFPLIAPQEFYDLY--------------------VRR 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 265 IISAdvnsfapsgipqwstlspeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANgvmatty 344
Cdd:cd16037 160 ARAA------------------------------YYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHGDM------- 202
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 345 pgnadgkyLGAfnneldnRGLpnsfvemgpgWaqassspfrlFKSFASEGGIRAPLMIKLPNAApsPGQWNKSFVHVTDL 424
Cdd:cd16037 203 --------LGE-------RGL----------W----------GKSTMYEESVRVPMIISGPGIP--AGKRVKTPVSLVDL 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 425 MPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQ-------EVHADGAGMGwelferkAYI--KGKWKVLRLPAPf 495
Cdd:cd16037 246 APTILEAAGAPPPPDLD--------GRSLLPLAEGPDDpdrvvfsEYHAHGSPSG-------AFMlrKGRWKYIYYVGY- 309
|
490
....*....|....*
gi 472840594 496 stgEWQLFDLEKDPG 510
Cdd:cd16037 310 ---PPQLFDLENDPE 321
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
27-511 |
2.02e-37 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 142.69 E-value: 2.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLgfsDIGPFGGNINTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVgimsevsypaVAN 105
Cdd:cd16147 1 RPNIVLILTDDQ---DVELGSMDPMPKTKKLLADQGTTFTNAFVtTPLCCPSRASILTGQYAHNHGV----------TNN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGYSGH-----LNNQVVTIPELLRESGYHTYMAGK----WHLGDDEGQIPsdRGFEESFALLqgGGSHYadqkplsppq 176
Cdd:cd16147 68 SPPGGGYpkfwqNGLERSTLPVWLQEAGYRTAYAGKylngYGVPGGVSYVP--PGWDEWDGLV--GNSTY---------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 177 vmDYR-----VNGKKIATLPADfYSTKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSGwds 251
Cdd:cd16147 134 --YNYtlsngGNGKHGVSYPGD-YLTDVIANKALDFLRRAAADDKPFFLVVAPPAPHGPFTPAPRYANLFPNVTAPP--- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 252 lrvlRLNNlkalgiisadvNSFAPSGIPQW----STLSPEQKAE----FAKDMEVYAAMVEyldmSIGRLLDYLKQQGLY 323
Cdd:cd16147 208 ----RPPP-----------NNPDVSDKPHWlrrlPPLNPTQIAYidelYRKRLRTLQSVDD----LVERLVNTLEATGQL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 324 DNTMIVFMSDNGangvmattypgnadgkY-LGAFNneldnrglpnsfveMGPGwaqassspfrlfKSFASEGGIRAPLMI 402
Cdd:cd16147 269 DNTYIIYTSDNG----------------YhLGQHR--------------LPPG------------KRTPYEEDIRVPLLV 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 403 KLPNAApsPGQWNKSFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQEVHADGAGMGWELFErkayi 482
Cdd:cd16147 307 RGPGIP--AGVTVDQLVSNIDLAPTILDLAGAPPPSDMD--------GRSCGDSNNNTYKCVRTVDDTYNLLYFE----- 371
|
490 500
....*....|....*....|....*....
gi 472840594 483 kgkwkvlrlpapFSTGEWQLFDLEKDPGE 511
Cdd:cd16147 372 ------------WCTGFRELYDLTTDPYQ 388
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-533 |
7.17e-37 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 141.60 E-value: 7.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNIN-TPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVGIMSEVSYPAVAN 105
Cdd:cd16150 1 PNIVIFVADQLRADSLGHLGNPAAvTPNLDALAAEGVRFSNAYCqNPVCSPSRCSFLTGWYPHVNGHRTLHHLLRPDEPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LpgysghlnnqvvtiPELLRESGYHTYMAGKWHLgddegqIPSDRGFEEsfallqgggshYADQkplsppqvmDYrvngk 185
Cdd:cd16150 81 L--------------LKTLKDAGYHVAWAGKNDD------LPGEFAAEA-----------YCDS---------DE----- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatlpadfystkNYTDTLIHYIdKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYKGkfdsgwDSLRVLRLNNLKALGi 265
Cdd:cd16150 116 -------------ACVRTAIDWL-RNRRPDKPFCLYLPLIFPHPPYGVEEPWFSMIDR------EKLPPRRPPGLRAKG- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 266 isadvnsfAPSGIPQ-----WSTLSPEQKAEFAKdmeVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNgangvm 340
Cdd:cd16150 175 --------KPSMLEGiekqgLDRWSEERWRELRA---TYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSDH------ 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 341 attypgnadGKYLGAFnneldnrGL----PNSFVEMgpgwaqassspfrLfksfaseggIRAPLMIKLPNAApsPGQWNK 416
Cdd:cd16150 238 ---------GDYTGDY-------GLvekwPNTFEDC-------------L---------TRVPLIIKPPGGP--AGGVSD 277
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 417 SFVHVTDLMPTVLQLAEV--SYPaQFkekavrqpiGKSLLPVLTGTAQE----VHADGaGMG------WELFERKAYIKG 484
Cdd:cd16150 278 ALVELVDIPPTLLDLAGIplSHT-HF---------GRSLLPVLAGETEEhrdaVFSEG-GRLhgeeqaMEGGHGPYDLKW 346
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 472840594 485 K---------------------WK-VLRLpapfsTGEWQLFDLEKDPGEANDL--SQQFPALRDSLVNEWLKY 533
Cdd:cd16150 347 PrllqqeeppehtkavmirtrrYKyVYRL-----YEPDELYDLEADPLELHNLigDPAYAEIIAEMKQRLLRW 414
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
27-467 |
1.25e-35 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 138.72 E-value: 1.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFGGNINTP-VLDQFSKEGMLFSNFYVLPT-CSPTRSALLTGNDNHVAGVGIMSEVSYPAVA 104
Cdd:cd16160 1 KPNIVLFFADDMGYGDLASYGHPTQERgPIDDMAAEGIRFTQAYSADSvCTPSRAALLTGRLPIRSGMYGGTRVFLPWDI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 -NLPGYSghlnnqvVTIPELLRESGYHTYMAGKWHLG------DDEGQIPSDRGFEESFALLQGGGSHYAD--QKPLSPP 175
Cdd:cd16160 81 gGLPKTE-------VTMAEALKEAGYTTGMVGKWHLGinennhSDGAHLPSHHGFDFVGTNLPFTNSWACDdtGRHVDFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 176 QV-MDYRVNGKKIATLPADFystKNYTDTLIH----YIDKNKgdQKPFFIYASYTAPHDPLQAPKEyidkYKGKfdsgwd 250
Cdd:cd16160 154 DRsACFLYYNDTIVEQPIQH---EHLTETLVGdaksFIEDNQ--ENPFFLYFSFPQTHTPLFASKR----FKGK------ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 251 SLRvlrlnnlkalGIISADVNSFApsgipqWstlspeqkaefakdmevyaamveyldmSIGRLLDYLKQQGLYDNTMIVF 330
Cdd:cd16160 219 SKR----------GRYGDNINEMS------W---------------------------AVGEVLDTLVDTGLDQNTLVFF 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 331 MSDNGangvmattypgnadgkylgafnneldnrglPN-SFVEMGpgwaqASSSPFRLFKSFASEGGIRAPLMIKLPNAAp 409
Cdd:cd16160 256 LSDHG------------------------------PHvEYCLEG-----GSTGGLKGGKGNSWEGGIRVPFIAYWPGTI- 299
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 472840594 410 sPGQWNKSFVHVTDLMPTVLQLAEVSYPAQfkekavRQPIGKSLLPVLTGTAQEVHAD 467
Cdd:cd16160 300 -KPRVSHEVVSTMDIFPTFVDLAGGTLPTD------RIYDGLSITDLLLGEADSPHDD 350
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
28-509 |
9.66e-35 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 133.47 E-value: 9.66e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNI-NTPVLDQFSKEGMLFSNFY-VLPTCSPTRSALLTGNDNHVAGVgimsevsYPAVAN 105
Cdd:cd16032 1 PNILLIMADQLTAAALPAYGNTVvKTPNLDRLAARGVVFDNAYcNSPLCAPSRASMMTGRLPSRIGA-------YDNAAE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGysghlnnQVVTIPELLRESGYHTYMAGKWHL-GDDegQIpsdRGF---EESfallqgggSHYADQKplsppqVMDYR 181
Cdd:cd16032 74 FPA-------DIPTFAHYLRAAGYRTALSGKMHFvGPD--QL---HGFdydEEV--------AFKAVQK------LYDLA 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 182 vngkkiatlpadfystknytdtlihyidkNKGDQKPFFIYASYTAPHDPLQAPKEYIDKYkgkfdsgwdslrVLRlnnlk 261
Cdd:cd16032 128 -----------------------------RGEDGRPFFLTVSFTHPHDPYVIPQEYWDLY------------VRR----- 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 262 algiisadvnsfapsgipqwstlspeqkAEFAkdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGAngvMa 341
Cdd:cd16032 162 ----------------------------ARRA-----YYGMVSYVDDKVGQLLDTLERTGLADDTIVIFTSDHGD---M- 204
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 342 ttypgnadgkylgafnneLDNRGLpnsfvemgpgWaqassspfrlFKSFASEGGIRAPLMIKLPN-AAPSPGQWNKSFVh 420
Cdd:cd16032 205 ------------------LGERGL----------W----------YKMSFFEGSARVPLIISAPGrFAPRRVAEPVSLV- 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 421 vtDLMPTVLQLAEVSYPaqfkekAVRQPI-GKSLLPVLTGT----AQEVHADGAGMG--WELFERKayiKGKWKVLRLPA 493
Cdd:cd16032 246 --DLLPTLVDLAGGGTA------PHVPPLdGRSLLPLLEGGdsggEDEVISEYLAEGavAPCVMIR---RGRWKFIYCPG 314
|
490
....*....|....*.
gi 472840594 494 PFStgewQLFDLEKDP 509
Cdd:cd16032 315 DPD----QLFDLEADP 326
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
27-515 |
1.11e-33 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 131.58 E-value: 1.11e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFGGNIN-TPVLDQFSKEGMLFSN-FYVLPTCSPTRSALLTGndnhvagvgimsevSYPAVA 104
Cdd:cd16152 1 KPNVIVFFTDQQRWDTLGCYGQPLDlTPNLDALAEEGVLFENaFTPQPVCGPARACLQTG--------------LYPTET 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGddegqipsdrgfeesfallqgggshyadqkplsppqvmDYRVng 184
Cdd:cd16152 67 GCFRNGIPLPADEKTLAHYFRDAGYETGYVGKWHLA--------------------------------------GYRV-- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 185 kkiatlpaDFystknYTDTLIHYIDKNKGDqKPFFIYASYTAPH-----DPLQAPKEYIDKYKGKFDSGwdslrvlrlnN 259
Cdd:cd16152 107 --------DA-----LTDFAIDYLDNRQKD-KPFFLFLSYLEPHhqndrDRYVAPEGSAERFANFWVPP----------D 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 260 LKALGiisADvnsfapsgipqwstlSPEQKAEfakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGANgv 339
Cdd:cd16152 163 LAALP---GD---------------WAEELPD-------YLGCCERLDENVGRIRDALKELGLYDNTIIVFTSDHGCH-- 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 340 mattypgnadgkylgaF---NNEldnrglpnsfvemgpgwaqassspfrlFKSFASEGGIRAPLMIKLPNAapSPGQWNK 416
Cdd:cd16152 216 ----------------FrtrNAE---------------------------YKRSCHESSIRVPLVIYGPGF--NGGGRVE 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 417 SFVHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQevhadgagmGWelfERKAYIK------------G 484
Cdd:cd16152 251 ELVSLIDLPPTLLDAAGIDVPEEMQ--------GRSLLPLVDGKVE---------DW---RNEVFIQisesqvgrairtD 310
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 472840594 485 KWKvLRLPAPFSTG----------EWQLFDLEKDPGEANDL 515
Cdd:cd16152 311 RWK-YSVAAPDKDGwkdsgsdvyvEDYLYDLEADPYELVNL 350
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
28-348 |
1.56e-33 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 133.34 E-value: 1.56e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGG-NINTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVgimsevsYPAVAN 105
Cdd:cd16158 2 PNIVLLFADDLGYGDLGCYGHpSSSTPNLDRLAANGLRFTDFYSsSPVCSPSRAALLTGRYQVRSGV-------YPGVFY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 lPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQ--IPSDRGFEESFALLQgggSHyaDQKPLS-----PPQVM 178
Cdd:cd16158 75 -PGSRGGLPLNETTIAEVLKTVGYQTAMVGKWHLGVGLNGtyLPTHQGFDHYLGIPY---SH--DQGPCQnltcfPPNIP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 179 DYR-----------VNGKKIATLPADFYS-TKNYTDTLIHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYIDKY-KGKF 245
Cdd:cd16158 149 CFGgcdqgevpcplFYNESIVQQPVDLLTlEERYAKFAKDFIADNAKEGKPFFLYYASHHTHYPQFAGQKFAGRSsRGPF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 246 DsgwDSLrvlrlnnlkalgiisadvnsfapsgipqwstlspeqkaefakdMEvyaamveyLDMSIGRLLDYLKQQGLYDN 325
Cdd:cd16158 229 G---DAL-------------------------------------------AE--------LDGSVGELLQTLKENGIDNN 254
|
330 340
....*....|....*....|...
gi 472840594 326 TMIVFMSDNGANgVMATTYPGNA 348
Cdd:cd16158 255 TLVFFTSDNGPS-TMRKSRGGNA 276
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
27-543 |
2.40e-32 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 130.49 E-value: 2.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFGGN-INTPVLDQFSKEGM-LFSNFYVLPTCSPTRSALLTGNDNHVAGvgiMSEVSYPAVA 104
Cdd:cd16159 1 KPNIVLFMADDLGIGDVGCFGNDtIRTPNIDRLAKEGVkLTHHLAAAPLCTPSRAAFLTGRYPIRSG---MASSHGMRVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWHLG------DDEGQIPSDRGFEESFAL-------LQGGGSHYADQKP 171
Cdd:cd16159 78 LFTASSGGLPPNETTFAEVLKQQGYSTALIGKWHLGlhcesrNDFCHHPLNHGFDYFYGLpltnlkdCGDGSNGEYDLSF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 172 ------------------------------------------LSPPQVMDYR--------VNGKKIATLPADFYS-TKNY 200
Cdd:cd16159 158 dplfplltafvlitaltiflllylgavskrffvfllilsllfISLFFLLLITnryfncilMRNHEVVEQPMSLENlTQRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 201 TDTLIHYIDKNKgdQKPFFIYASYTAPHDPLQAPKeyidKYKGKFDSGwdslrvlrlnnlkalgiisadvnsfapsgipq 280
Cdd:cd16159 238 TKEAISFLERNK--ERPFLLVMSFLHVHTALFTSK----KFKGRSKHG-------------------------------- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 281 wstlspeqkaefakdmeVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGA-------NGVMATTYPGNADGKyl 353
Cdd:cd16159 280 -----------------RYGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGhleeisvGGEYGGGNGGIYGGK-- 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 354 gafnneldnrglpnsfveMGPGWaqassspfrlfksfasEGGIRAPLMIKLPNAAPsPGQWNKSFVHVTDLMPTVLQLAE 433
Cdd:cd16159 341 ------------------KMGGW----------------EGGIRVPTIVRWPGVIP-PGSVIDEPTSLMDIFPTVAALAG 385
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 434 VSYPAQfkekavRQPIGKSLLPVLTGTAQ-------------EVHA------DGaGMGWELFerkaYIKGKWK------- 487
Cdd:cd16159 386 APLPSD------RIIDGRDLMPLLTGQEKrspheflfhycgaELHAvryrprDG-GAVWKAH----YFTPNFYpgtegcc 454
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 472840594 488 ---VLRLPAPFSTG--EWQLFDLEKDPGEANDLSQQfpalrDSLVNEWLKYAKaNDVFDHR 543
Cdd:cd16159 455 gtlLCRCFGDSVTHhdPPLLFDLSADPSESNPLDPT-----DEPYQEIIKKIL-EAVAEHQ 509
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-455 |
3.86e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 124.58 E-value: 3.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFG-GNINTPVLDQFSKEGMLFSNFYVL-PTCSPTRSALLTGNDNHVAGVgimsevsypavan 105
Cdd:cd16148 1 MNVILIVIDSLRADHLGCYGyDRVTTPNLDRLAAEGVVFDNHYSGsNPTLPSRFSLFTGLYPFYHGV------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 lpgYSGHLNNQVVTIPELLRESGYHTymagkwHLGDDEGQIPSDRGFEESFALLQGGGSHYADQKplsppqvmdyrvngk 185
Cdd:cd16148 68 ---WGGPLEPDDPTLAEILRKAGYYT------AAVSSNPHLFGGPGFDRGFDTFEDFRGQEGDPG--------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatlPADFYSTKNYTDTLIHYIDKNKGDqKPFFIYASYTAPHDPLQapkeyidkykgkfdsgwdslrvlrlnnlkalgi 265
Cdd:cd16148 124 -----EEGDERAERVTDRALEWLDRNADD-DPFFLFLHYFDPHEPYL--------------------------------- 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 266 isadvnsfapsgipqwstlspeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvmattyp 345
Cdd:cd16148 165 ---------------------------------YDAEVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHG---------- 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 346 gnadgkylgafnnELdnrglpnsFVEMGPGWAQASSspfrlfksfASEGGIRAPLMIKLPNAApsPGQWNKSFVHVTDLM 425
Cdd:cd16148 202 -------------EE--------FGEHGLYWGHGSN---------LYDEQLHVPLIIRWPGKE--PGKRVDALVSHIDIA 249
|
410 420 430
....*....|....*....|....*....|
gi 472840594 426 PTVLQLAEVSYPAQFkekavrqpIGKSLLP 455
Cdd:cd16148 250 PTLLDLLGVEPPDYS--------DGRSLLP 271
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
27-434 |
7.10e-24 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 101.68 E-value: 7.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 27 RPNILFIVADDLGFSDIGPFG-----------GNINTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAGVgI 94
Cdd:cd16153 1 KPNILWIITDDQRVDSLSCYNnahtgksesrlGYVESPNIDALAAEGVLFTNAYCnSPVCVPSRTSMLTGRYPHRTGV-Y 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 95 MSEVSYPAVANLPgysghlnnqvVTIPELLRESGYHTYMAGKWHlgddegqipsdrgfeesfallqgggsHYADQKPLSP 174
Cdd:cd16153 80 GFEAAHPALDHGL----------PTFPEVLKKAGYQTASFGKSH--------------------------LEAFQRYLKN 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 175 PQVMDYRVNGKKIATLPADfystknytdtlihyidknkgdqKPFFIYASYTAPHDPLQAPKEYIDKYKgkfdsgwdslrv 254
Cdd:cd16153 124 ANQSYKSFWGKIAKGADSD----------------------KPFFVRLSFLQPHTPVLPPKEFRDRFD------------ 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 255 lrlnnlkalgiisadvnsfapsgipqwstlspeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLY---DNTMIVFM 331
Cdd:cd16153 170 --------------------------------------------YYAFCAYGDAQVGRAVEAFKAYSLKqdrDYTIVYVT 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 332 SDNGANgvmattypgnadgkyLGafnneldnrglpnsfvEMGpgwAQASSSPFrlfksfasEGGIRAPLMIKLPNAAPSP 411
Cdd:cd16153 206 GDHGWH---------------LG----------------EQG---ILAKFTFW--------PQSHRVPLIVVSSDKLKAP 243
|
410 420
....*....|....*....|....
gi 472840594 412 -GQWNKSFVHVTDLMPTVLQLAEV 434
Cdd:cd16153 244 aGKVRHDFVEFVDLAPTLLAAAGV 267
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
28-459 |
1.11e-23 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 101.52 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFG-GNINTPVLDQFSKEGMLFSNFYVLPT-CSPTRSALLTGNdnHVAGVGIMSEVSYPAVAN 105
Cdd:cd16035 1 PNILLILTDQERYPPPWPAGwAALNLPARERLAANGLSFENHYTAACmCSPSRSTLYTGL--HPQQTGVTDTLGSPMQPL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPgysghlnNQVVTIPELLRESGYHTYMAGKWHLGDdegqipsdrgfeesfalLQGGGSHYADQkplsppqvmdyrvngk 185
Cdd:cd16035 79 LS-------PDVPTLGHMLRAAGYYTAYKGKWHLSG-----------------AAGGGYKRDPG---------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 186 kiatlpadfystknYTDTLIHYIDK---NKGDQKPFFIYASYTAPHDPLQAPKeyidkykgkfdsgwDSLRVLRLNNLka 262
Cdd:cd16035 119 --------------IAAQAVEWLRErgaKNADGKPWFLVVSLVNPHDIMFPPD--------------DEERWRRFRNF-- 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 263 lgiisadvnsfapsgipqwstlspeqkaefakdmevYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNG----ANG 338
Cdd:cd16035 169 ------------------------------------YYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHGemggAHG 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 339 VMattypgnadgkylgafnneldnRGLPNSFVEMgpgwaqassspfrlfksfaseggIRAPLMIKLPNAAPSPGQWNKSF 418
Cdd:cd16035 213 LR----------------------GKGFNAYEEA-----------------------LHVPLIISHPDLFGTGQTTDALT 247
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 472840594 419 VHVtDLMPTVLQLAEVsyPAQFKEKAVRQPIGKSLLPVLTG 459
Cdd:cd16035 248 SHI-DLLPTLLGLAGV--DAEARATEAPPLPGRDLSPLLTD 285
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
28-432 |
7.18e-18 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 82.85 E-value: 7.18e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDLGFSDIGPFGGNI-NTPVLDQFSKEGMLFSNFYVLPTCS--PTRSALLTGNDNHVAGVGIMSEvsypAVA 104
Cdd:cd00016 1 KHVVLIVLDGLGADDLGKAGNPApTTPNLKRLASEGATFNFRSVSPPTSsaPNHAALLTGAYPTLHGYTGNGS----ADP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 105 NLPGYSGHLNNQVVTIPELLRESGYHTYMagkwhlgddegqipsdrgfeesFALLQgggshyadqkplsppqvmdyrvng 184
Cdd:cd00016 77 ELPSRAAGKDEDGPTIPELLKQAGYRTGV----------------------IGLLK------------------------ 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 185 kkiatlpadfystknytdtlihYIDKNKgDQKPFFIYASYTAPHDPLQApkeyidkykgkfdsgwdslrvlrlnnlkalg 264
Cdd:cd00016 111 ----------------------AIDETS-KEKPFVLFLHFDGPDGPGHA------------------------------- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 265 iisadvnsfapsgipqwstlspeqkaeFAKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvmatty 344
Cdd:cd00016 137 ---------------------------YGPNTPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHG--------- 180
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 345 pgnadgkylgafnneldnrglpNSFVEMGPgwaqassSPFRLFKSFASEGGIRAPLMIKLPNAapsPGQWNKS-FVHVTD 423
Cdd:cd00016 181 ----------------------GIDKGHGG-------DPKADGKADKSHTGMRVPFIAYGPGV---KKGGVKHeLISQYD 228
|
....*....
gi 472840594 424 LMPTVLQLA 432
Cdd:cd00016 229 IAPTLADLL 237
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
28-333 |
8.84e-17 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 80.80 E-value: 8.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADdlGFSD--IGPFGGNIN-TPVLDQFSKEGMLFSNFYVLPTCSPT-RS--ALLTGNdnhvagvgimsevsYP 101
Cdd:cd16015 1 PNVIVILLE--SFSDpyIDKDVGGEDlTPNLNKLAKEGLYFGNFYSPGFGGGTaNGefEVLTGL--------------PP 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 102 AVANLPGYSGHLNNQVVTIPELLRESGYHTYMagkWHlgddegqiPSDRGFE--ESFALLQGGgSHYADQKPLSPPQVMD 179
Cdd:cd16015 65 LPLGSGSYTLYKLNPLPSLPSILKEQGYETIF---IH--------GGDASFYnrDSVYPNLGF-DEFYDLEDFPDDEKET 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 180 YRvngkkiatlpaDFYSTKNYTDTLIHYIDKNKgdQKPFFIYASYTAPHDPLQAPKEYIDKYKGKFDSGwdslrvlrlnn 259
Cdd:cd16015 133 NG-----------WGVSDESLFDQALEELEELK--KKPFFIFLVTMSNHGPYDLPEEKKDEPLKVEEDK----------- 188
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 472840594 260 lkalgiisadvnsfapsgipqwstlspeqkaefaKDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSD 333
Cdd:cd16015 189 ----------------------------------TELENYLNAIHYTDKALGEFIEKLKKSGLYENTIIVIYGD 228
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
17-454 |
1.35e-16 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 82.78 E-value: 1.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 17 QKQNEEILPQRPNILFIVADDLGFSDIGPFGGNIN-TPVLDQFSKEGMLFSNFYVlPTcspTRS-----ALLTGndnhva 90
Cdd:COG1368 224 PTPNPFGPAKKPNVVVILLESFSDFFIGALGNGKDvTPFLDSLAKESLYFGNFYS-QG---GRTsrgefAVLTG------ 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 91 gvgimsevsYPAVANLPGYSGHLNNQVVTIPELLRESGYHTYMagkWHlgddegqipsdrGFEESF----ALLQGGG-SH 165
Cdd:COG1368 294 ---------LPPLPGGSPYKRPGQNNFPSLPSILKKQGYETSF---FH------------GGDGSFwnrdSFYKNLGfDE 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 166 YADQKPLSPPQVMDYRVNGKkiatlpaDFYStknytdtliHYIDKNKGDQKPFFIYASYTAPHDPLQAPKEYidKYKGKF 245
Cdd:COG1368 350 FYDREDFDDPFDGGWGVSDE-------DLFD---------KALEELEKLKKPFFAFLITLSNHGPYTLPEED--KKIPDY 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 246 DSGwdslrvlrlnnlkalgiisadvnsfapsgipqwstlspeqkaefakDMEVYAAMVEYLDMSIGRLLDYLKQQGLYDN 325
Cdd:COG1368 412 GKT----------------------------------------------TLNNYLNAVRYADQALGEFIEKLKKSGWYDN 445
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 326 TMIVFMSDNGAnGVMATTYPGNADGKYlgafnneldnrglpnsfvemgpgwaqassspfrlfksfaseggiRAPLMIKLP 405
Cdd:COG1368 446 TIFVIYGDHGP-RSPGKTDYENPLERY--------------------------------------------RVPLLIYSP 480
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 472840594 406 NAApsPGQWNKSFVHVTDLMPTVLQLAEVSYPAQFkekavrqPIGKSLL 454
Cdd:COG1368 481 GLK--KPKVIDTVGSQIDIAPTLLDLLGIDYPSYY-------AFGRDLL 520
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
28-509 |
1.14e-09 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 60.25 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 28 PNILFIVADDL-GFSDIGPFGGNINTPVLDQFSKEGMLFSNFYV-LPTCSPTRSALLTGNDNHVAgvgimsevsypavAN 105
Cdd:cd16171 1 PNVVMVMSDSFdGRLTFRPGNQVVDLPYINFMKQHGSVFLNAYTnSPICCPSRAAMWSGLFTHLT-------------ES 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 106 LPGYSGhLNNQVVTIPELLRESGYHTYMAGKWHLGDDEGQIpSDR----GFEESFALLQGGgshyadqKPlsppqVMDYR 181
Cdd:cd16171 68 WNNYKG-LDPNYPTWMDRLEKHGYHTQKYGKLDYTSGHHSV-SNRveawTRDVPFLLRQEG-------RP-----TVNLV 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 182 VNGKKIATLPADFYSTknytDTLIHYIDKNKGD-QKPFFIYASYTAPHdplQAPKEYIDKYKGkfdsgwdSLRVLRlnnl 260
Cdd:cd16171 134 GDRSTVRVMLKDWQNT----DKAVHWIRKEAPNlTQPFALYLGLNLPH---PYPSPSMGENFG-------SIRNIR---- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 261 kalgiisadvnsfapsgipqwstlspeqkaefakdmEVYAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvm 340
Cdd:cd16171 196 ------------------------------------AFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHG----- 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 341 attypgnadgkylgafnnEL--DNRglpnsfvemgpgwaqassspfRLFKSFASEGGIRAPLMIKLPNAapSPGQWNKSF 418
Cdd:cd16171 235 ------------------ELamEHR---------------------QFYKMSMYEGSSHVPLLIMGPGI--KAGQQVSDV 273
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 419 VHVTDLMPTVLQLAEVSYPAQFKekavrqpiGKSLLPVLTGTAQEVHAD-GAGMGWELFE-------RKAYI--KGKWKV 488
Cdd:cd16171 274 VSLVDIYPTMLDIAGVPQPQNLS--------GYSLLPLLSESSIKESPSrVPHPDWVLSEfhgcnvnASTYMlrTNSWKY 345
|
490 500
....*....|....*....|....
gi 472840594 489 LrlpaPFSTGEW---QLFDLEKDP 509
Cdd:cd16171 346 I----AYADGNSvppQLFDLSKDP 365
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
1-435 |
2.80e-08 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 55.91 E-value: 2.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 1 MKKLFPFILAALAACGQKQNeeilPQRPNILFIVADDLGFSDIGPFggniNTPVLDQFSKEGMLFSNFY-VLPTCSPT-R 78
Cdd:COG1524 1 MKRGLSLLLASLLAAAAAAA----PPAKKVVLILVDGLRADLLERA----HAPNLAALAARGVYARPLTsVFPSTTAPaH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 79 SALLTGN--DNHvagvGIMS---------EVSYPAVANLPGYSGHLNNQVVTIPELLRESGYHTYMAGKWhlgddegqip 147
Cdd:COG1524 73 TTLLTGLypGEH----GIVGngwydpelgRVVNSLSWVEDGFGSNSLLPVPTIFERARAAGLTTAAVFWP---------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 148 sdrGFEESfallqgGGSHYAdqkplsppqvMDYRVNGKKIatLPADFYSTKNYTDTLIHYIDKNKgdqkPFFIYASYtaP 227
Cdd:COG1524 139 ---SFEGS------GLIDAA----------RPYPYDGRKP--LLGNPAADRWIAAAALELLREGR----PDLLLVYL--P 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 228 HdplqapkeyIDKYKGKFdsGWDSlrvlrlnnlkalgiisadvnsfapsgiPQWstlspeqkaefakdmevyAAMVEYLD 307
Cdd:COG1524 192 D---------LDYAGHRY--GPDS---------------------------PEY------------------RAALREVD 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 308 MSIGRLLDYLKQQGLYDNTMIVFMSDNG---------------------ANGVMATTYPGNADG----KYLGAF-----N 357
Cdd:COG1524 216 AALGRLLDALKARGLYEGTLVIVTADHGmvdvppdidlnrlrlagllavRAGESAHLYLKDGADaevrALLGLParvltR 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 358 NELDNRGLPNS-----FVEMGPGWAQASSSPfrlfksfASEGGI-----RAPLMIKLPNAapspgqwnKSFVHVTDLMPT 427
Cdd:COG1524 296 EELAAGHFGPHrigdlVLVAKPGWALDAPLK-------GSHGGLpdeemRVPLLASGPGF--------RPGVRNVDVAPT 360
|
....*...
gi 472840594 428 VLQLAEVS 435
Cdd:COG1524 361 IARLLGLP 368
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
297-387 |
1.19e-04 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 44.11 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472840594 297 EVYAAmVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGangvMATTypGNadgkyLGAFNNELDNRGLpnsFVEMGPGW 376
Cdd:cd16018 180 EVNEA-LKRVDRRLGYLIEALKERGLLDDTNIIVVSDHG----MTDV--GT-----HGYDNELPDMRAI---FIARGPAF 244
|
90
....*....|..
gi 472840594 377 -AQASSSPFRLF 387
Cdd:cd16018 245 kKGKKLGPFRNV 256
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
295-336 |
1.97e-04 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 43.56 E-value: 1.97e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 472840594 295 DMEVYAAmVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGA 336
Cdd:pfam01663 184 SPEVEDA-LRRVDRAIGDLLEALDERGLFEDTNVIVVSDHGM 224
|
|
| ALP_like |
cd16021 |
uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific ... |
299-346 |
3.85e-04 |
|
uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity.
Pssm-ID: 293745 Cd Length: 278 Bit Score: 42.51 E-value: 3.85e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 472840594 299 YAAMVEYLDMSIGRLLDYLKQQGLYDNTMIVFMSDNGAN-GVMATTYPG 346
Cdd:cd16021 178 YLNGLSLADEDLLEFLKRLKENGLLDNTFVIFMSDHGLRfGKIRETLQG 226
|
|
| |
