|
Name |
Accession |
Description |
Interval |
E-value |
| aceE |
PRK09405 |
pyruvate dehydrogenase subunit E1; Reviewed |
1-887 |
0e+00 |
|
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain] Cd Length: 891 Bit Score: 1958.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 1 MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELER 80
Cdd:PRK09405 4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASA-TTPYINTIPVEEEPEYPGDLELER 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 81 RIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQ 160
Cdd:PRK09405 83 RIRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 161 EQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESK 240
Cdd:PRK09405 163 EQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 241 GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVD 320
Cdd:PRK09405 243 GAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVD 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 321 GDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDA 400
Cdd:PRK09405 323 GDYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 401 AEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFtEKLELPSLQ 480
Cdd:PRK09405 403 GEGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALS 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 481 DFGALLEEQSK-EISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKE 559
Cdd:PRK09405 482 AFEALLKGSGErEISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKE 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 560 DEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGL 639
Cdd:PRK09405 562 SKDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGL 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 640 QHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLET 719
Cdd:PRK09405 642 QHEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLET 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 720 IEGSKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA- 796
Cdd:PRK09405 721 AEGKKGKpkVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGAe 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 797 -PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF 875
Cdd:PRK09405 801 gPVVAATDYMKLFAEQIRAFVPG-DYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKY 879
|
890
....*....|..
gi 476961654 876 NIDADKVNPRLA 887
Cdd:PRK09405 880 GIDPDKANPRTA 891
|
|
| AceE |
COG2609 |
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ... |
6-887 |
0e+00 |
|
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain] Cd Length: 891 Bit Score: 1915.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 6 PNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIRSA 85
Cdd:COG2609 10 LPDIDPQETQEWLESLDAVIEEEGPERARYLLERLLERARRSGVGLPFSA-TTPYINTIPVEQEPPYPGDEELERRIRSI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 86 IRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDN 165
Cdd:COG2609 89 IRWNAMAMVVRANRKGGGLGGHISSFASAATLYEVGFNHFFRGPDHPGGGDLVYFQGHASPGIYARAFLEGRLTEEQLDN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 166 FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITI 245
Cdd:COG2609 169 FRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLHNRGLKDTSDRKVWAFLGDGEMDEPESLGAISL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 246 ATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQT 325
Cdd:COG2609 249 AAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAGWNVIKVIWGSEWDPLLAKDTDGALVKRMNETVDGDYQT 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 326 FKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKN 405
Cdd:COG2609 329 YKAKDGAYVREHFFGKYPELKALVADMSDEDIWRLNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEAGEGRN 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 406 IAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNfTEKLELPSLQDFGAL 485
Cdd:COG2609 409 ITHQQKKLDLDDLKAFRDRFNIPISDEQLEELPYYKPAEDSPEMKYLHERRKALGGYLPQRRTK-AEPLEVPELSAFAAL 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 486 LE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQ 564
Cdd:COG2609 488 LKgSGKREISTTMAFVRILNDLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPVGQLYTPVDADQLLYYKESKDGQ 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 565 ILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDG 644
Cdd:COG2609 568 ILQEGINEAGAMSSWIAAGTSYSTHGVPMIPFYIYYSMFGFQRVGDLAWAAGDQRARGFLIGATAGRTTLNGEGLQHQDG 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 645 HSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG-S 723
Cdd:COG2609 648 HSHLLASTIPNCVSYDPAFAYELAVIVQDGLRRMYGE-QENVFYYITVMNENYAQPAMPEGVEEGILKGMYLLKEGEGkG 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 724 KGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA--PAVAS 801
Cdd:COG2609 727 KPRVQLLGSGTILREVLAAAELLAEDWGVAADVWSVTSFNELRRDGLDVERWNLLHPEEEPRVPYVTQCLAGAegPVVAA 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 802 TDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADK 881
Cdd:COG2609 807 TDYMRAVPDQIRPWVPG-RYTVLGTDGFGRSDTREALRRFFEVDRYSIVVAALKALADEGKIDASVVAEAIKKYGIDPDK 885
|
....*.
gi 476961654 882 VNPRLA 887
Cdd:COG2609 886 PNPLTA 891
|
|
| aceE |
TIGR00759 |
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ... |
4-887 |
0e+00 |
|
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain] Cd Length: 885 Bit Score: 1712.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 4 RFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIR 83
Cdd:TIGR00759 1 SQPNDVDPIETQEWLESLDSVLAEEGPARARYLLEQLLEYAREHGVPIPAGT-TTDYINTIPVEEQPAYPGDLELERRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 84 SAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQL 163
Cdd:TIGR00759 80 SIIRWNAIAMVLRANKKDLGLGGHISTYASAATLYEVGFNHFFRGHSEGGGGDLVFFQGHAAPGIYARAFLEGRLTEEQL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 164 DNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAI 243
Cdd:TIGR00759 160 DNFRQEVQGDGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLENRGLKDTGDQKVWAFLGDGEMDEPESKGAI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 244 TIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDY 323
Cdd:TIGR00759 240 TFAAREKLDNLTFVINCNLQRLDGPVRGNGKIIQELESLFRGAGWNVIKVLWGSEWDALLARDTSGVLVKLMNETVDGDY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 324 QTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEG 403
Cdd:TIGR00759 320 QTYKAKDGAYVREHFFNRTPELKALVADMSDADIWALNRGGHDPRKVYAAYAAAQEHKGQPTVILAKTIKGYGMGDAAES 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 404 KNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPnFTEKLELPSLQDFG 483
Cdd:TIGR00759 400 RNTAHQVKKLEVDALKNFRDRFELPLSDAQVEELPYYHPGEGSPEVRYLLARRQALGGYLPARRT-FAEHLTVPALEFFG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 484 ALLEEQS-KEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEK 562
Cdd:TIGR00759 479 ALLKGSGeREVSTTMAFVRILNKLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPHGQTYTPVDADSLLAYKESKD 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 563 GQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINEAGAMASWIAAATSYATHGEPMIPFYIYYSMFGFQRIGDLCWAAADQRARGFLLGATAGRTTLNGEGLQHE 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 643 DGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG 722
Cdd:TIGR00759 639 DGHSLLQAATIPNCIAYDPAFAYEVAVIMEDGLRRMYGE-QEDVFYYVTVMNENYVQPPMPEGAEEGILKGLYRFETSTE 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 723 SKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMN--DAPA 798
Cdd:TIGR00759 718 EKAKghVQLLGSGAIMRAVIEAAQLLAADWGVASDVWSVTSFTELARDGHDVERWNLLHPTETPRVSYVAQVLNeaDAPV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 799 VASTDYMKLFAEQVRTYVPaDDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNID 878
Cdd:TIGR00759 798 IASTDYVRAFAEQIRPYVP-RKYVTLGTDGFGRSDTRENLRHFFEVDAKSVVLAALYALADDGEIDGDVVADAIAKYGID 876
|
....*....
gi 476961654 879 ADKVNPRLA 887
Cdd:TIGR00759 877 PDKANPVYR 885
|
|
| TPP_E1_EcPDC_like |
cd02017 |
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ... |
76-461 |
0e+00 |
|
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain] Cd Length: 386 Bit Score: 748.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 76 LELERRIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLE 155
Cdd:cd02017 1 LEIERRIRSLIRWNAMAMVHRANKKDLGIGGHIATFASAATLYEVGFNHFFRARGEGGGGDLVYFQGHASPGIYARAFLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 156 GRLTQEQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMD 235
Cdd:cd02017 81 GRLTEEQLDNFRQEVGGGGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDRGLKDTSDQKVWAFLGDGEMD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 236 EPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLM 315
Cdd:cd02017 161 EPESLGAIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSKWDELLAKDGGGALRQRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 316 NETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGY 395
Cdd:cd02017 241 EETVDGDYQTLKAKDGAYVREHFFGKYPELKALVTDLSDEDLWALNRGGHDPRKVYAAYKKAVEHKGKPTVILAKTIKGY 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 476961654 396 GMGDAAEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHG 461
Cdd:cd02017 321 GLGAAGEGRNHAHQVKKMTEDELKALRDRFGIPVSDEQLEEGPYYKPPEGSEEIKYLHERRHALGG 386
|
|
| PDH_E1_M |
pfam17831 |
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ... |
474-700 |
2.21e-107 |
|
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain] Cd Length: 229 Bit Score: 330.54 E-value: 2.21e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 474 LELPSLQD--FGALLE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQD 550
Cdd:pfam17831 1 LEIPDLDDkiFASQTGgSKGREISTTMAFVRILNGLVKDKKIGKQVVPIIPDEARTFGMEGMFRQLGIYTSEGQKYEPVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 551 REQVAYYKEDEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSG 630
Cdd:pfam17831 81 KGQIMFYREDKQGQILEEGISEAGAMSAWIAAATSYSNHNTTLLPFYVYYSMFGFQRIGDLAWAAGDMQARGFLVGGTAG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 631 RTTLNGEGLQHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEKqENVYYYITTLNENYHMP 700
Cdd:pfam17831 161 RTTLNGEGLQHQDGHSHIQASTIPNCRSYDPTYAHEVAVIVQDGLKRMFADK-ENCFYYLTVMNENYEHP 229
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| aceE |
PRK09405 |
pyruvate dehydrogenase subunit E1; Reviewed |
1-887 |
0e+00 |
|
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain] Cd Length: 891 Bit Score: 1958.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 1 MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELER 80
Cdd:PRK09405 4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASA-TTPYINTIPVEEEPEYPGDLELER 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 81 RIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQ 160
Cdd:PRK09405 83 RIRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 161 EQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESK 240
Cdd:PRK09405 163 EQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 241 GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVD 320
Cdd:PRK09405 243 GAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVD 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 321 GDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDA 400
Cdd:PRK09405 323 GDYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 401 AEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFtEKLELPSLQ 480
Cdd:PRK09405 403 GEGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALS 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 481 DFGALLEEQSK-EISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKE 559
Cdd:PRK09405 482 AFEALLKGSGErEISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKE 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 560 DEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGL 639
Cdd:PRK09405 562 SKDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGL 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 640 QHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLET 719
Cdd:PRK09405 642 QHEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLET 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 720 IEGSKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA- 796
Cdd:PRK09405 721 AEGKKGKpkVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGAe 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 797 -PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF 875
Cdd:PRK09405 801 gPVVAATDYMKLFAEQIRAFVPG-DYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKY 879
|
890
....*....|..
gi 476961654 876 NIDADKVNPRLA 887
Cdd:PRK09405 880 GIDPDKANPRTA 891
|
|
| AceE |
COG2609 |
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ... |
6-887 |
0e+00 |
|
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain] Cd Length: 891 Bit Score: 1915.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 6 PNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIRSA 85
Cdd:COG2609 10 LPDIDPQETQEWLESLDAVIEEEGPERARYLLERLLERARRSGVGLPFSA-TTPYINTIPVEQEPPYPGDEELERRIRSI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 86 IRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDN 165
Cdd:COG2609 89 IRWNAMAMVVRANRKGGGLGGHISSFASAATLYEVGFNHFFRGPDHPGGGDLVYFQGHASPGIYARAFLEGRLTEEQLDN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 166 FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITI 245
Cdd:COG2609 169 FRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLHNRGLKDTSDRKVWAFLGDGEMDEPESLGAISL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 246 ATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQT 325
Cdd:COG2609 249 AAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAGWNVIKVIWGSEWDPLLAKDTDGALVKRMNETVDGDYQT 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 326 FKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKN 405
Cdd:COG2609 329 YKAKDGAYVREHFFGKYPELKALVADMSDEDIWRLNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEAGEGRN 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 406 IAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNfTEKLELPSLQDFGAL 485
Cdd:COG2609 409 ITHQQKKLDLDDLKAFRDRFNIPISDEQLEELPYYKPAEDSPEMKYLHERRKALGGYLPQRRTK-AEPLEVPELSAFAAL 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 486 LE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQ 564
Cdd:COG2609 488 LKgSGKREISTTMAFVRILNDLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPVGQLYTPVDADQLLYYKESKDGQ 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 565 ILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDG 644
Cdd:COG2609 568 ILQEGINEAGAMSSWIAAGTSYSTHGVPMIPFYIYYSMFGFQRVGDLAWAAGDQRARGFLIGATAGRTTLNGEGLQHQDG 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 645 HSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG-S 723
Cdd:COG2609 648 HSHLLASTIPNCVSYDPAFAYELAVIVQDGLRRMYGE-QENVFYYITVMNENYAQPAMPEGVEEGILKGMYLLKEGEGkG 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 724 KGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA--PAVAS 801
Cdd:COG2609 727 KPRVQLLGSGTILREVLAAAELLAEDWGVAADVWSVTSFNELRRDGLDVERWNLLHPEEEPRVPYVTQCLAGAegPVVAA 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 802 TDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADK 881
Cdd:COG2609 807 TDYMRAVPDQIRPWVPG-RYTVLGTDGFGRSDTREALRRFFEVDRYSIVVAALKALADEGKIDASVVAEAIKKYGIDPDK 885
|
....*.
gi 476961654 882 VNPRLA 887
Cdd:COG2609 886 PNPLTA 891
|
|
| aceE |
TIGR00759 |
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ... |
4-887 |
0e+00 |
|
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain] Cd Length: 885 Bit Score: 1712.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 4 RFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIR 83
Cdd:TIGR00759 1 SQPNDVDPIETQEWLESLDSVLAEEGPARARYLLEQLLEYAREHGVPIPAGT-TTDYINTIPVEEQPAYPGDLELERRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 84 SAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQL 163
Cdd:TIGR00759 80 SIIRWNAIAMVLRANKKDLGLGGHISTYASAATLYEVGFNHFFRGHSEGGGGDLVFFQGHAAPGIYARAFLEGRLTEEQL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 164 DNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAI 243
Cdd:TIGR00759 160 DNFRQEVQGDGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLENRGLKDTGDQKVWAFLGDGEMDEPESKGAI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 244 TIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDY 323
Cdd:TIGR00759 240 TFAAREKLDNLTFVINCNLQRLDGPVRGNGKIIQELESLFRGAGWNVIKVLWGSEWDALLARDTSGVLVKLMNETVDGDY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 324 QTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEG 403
Cdd:TIGR00759 320 QTYKAKDGAYVREHFFNRTPELKALVADMSDADIWALNRGGHDPRKVYAAYAAAQEHKGQPTVILAKTIKGYGMGDAAES 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 404 KNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPnFTEKLELPSLQDFG 483
Cdd:TIGR00759 400 RNTAHQVKKLEVDALKNFRDRFELPLSDAQVEELPYYHPGEGSPEVRYLLARRQALGGYLPARRT-FAEHLTVPALEFFG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 484 ALLEEQS-KEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEK 562
Cdd:TIGR00759 479 ALLKGSGeREVSTTMAFVRILNKLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPHGQTYTPVDADSLLAYKESKD 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 563 GQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINEAGAMASWIAAATSYATHGEPMIPFYIYYSMFGFQRIGDLCWAAADQRARGFLLGATAGRTTLNGEGLQHE 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 643 DGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG 722
Cdd:TIGR00759 639 DGHSLLQAATIPNCIAYDPAFAYEVAVIMEDGLRRMYGE-QEDVFYYVTVMNENYVQPPMPEGAEEGILKGLYRFETSTE 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 723 SKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMN--DAPA 798
Cdd:TIGR00759 718 EKAKghVQLLGSGAIMRAVIEAAQLLAADWGVASDVWSVTSFTELARDGHDVERWNLLHPTETPRVSYVAQVLNeaDAPV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 799 VASTDYMKLFAEQVRTYVPaDDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNID 878
Cdd:TIGR00759 798 IASTDYVRAFAEQIRPYVP-RKYVTLGTDGFGRSDTRENLRHFFEVDAKSVVLAALYALADDGEIDGDVVADAIAKYGID 876
|
....*....
gi 476961654 879 ADKVNPRLA 887
Cdd:TIGR00759 877 PDKANPVYR 885
|
|
| PRK13012 |
PRK13012 |
2-oxoacid dehydrogenase subunit E1; Provisional |
6-884 |
0e+00 |
|
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain] Cd Length: 896 Bit Score: 1517.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 6 PNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTGiSNYINTIPVEEQPEYPGNLELERRIRSA 85
Cdd:PRK13012 17 LPDIDPQETAEWLEALDAVVAHAGPERARYLLDRLLERAAARGIALPGLLT-TPYVNTIPVDQQPPYPGDLALEERLAAI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 86 IRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDN 165
Cdd:PRK13012 96 IRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRGRDDAGGGDLVYFQPHSAPGIYARAFLEGRLSEEQLDH 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 166 FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITI 245
Cdd:PRK13012 176 FRQEIGGPGLSSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQHRGLKDTSGRKVWGFFGDGEMDEPESIAALSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 246 ATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQT 325
Cdd:PRK13012 256 AAREGLDNLVFVINCNLQRLDGPVRGNGRIIQELEALFRGAGWNVIKVLWGSDWDALFARDTTGALVRRFAETVDGQFQT 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 326 FKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKN 405
Cdd:PRK13012 336 FKANDGAYNREHFFGQDPELAALVAHLSDEDIDRLKRGGHDPRKVYAAYAAAVRHKGQPTVILAKTKKGYGMGEAGEGRM 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 406 IAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNfTEKLELPSLQDFGA- 484
Cdd:PRK13012 416 TTHQQKKLDVEALKAFRDRFRLPLSDEQLEQLPFYKPAEDSPEMRYLHARRAALGGYLPRRRTA-APPLPVPPLSAFAQf 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 485 LLEEQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQ 564
Cdd:PRK13012 495 ALGAGGKEMSTTMAFVRMLGNLLKDKALGPRIVPIVADEARTFGMANLFRQVGIYSPLGQLYEPEDAGSLLYYREAKDGQ 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 565 ILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDG 644
Cdd:PRK13012 575 ILEEGITEAGAISSWIAAATSYSVHGLPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG 654
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 645 HSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLeTIEGSK 724
Cdd:PRK13012 655 HSHLLASTIPNCRAYDPAFAYELAVIVDDGMRRMLEE-QEDVFYYLTVMNENYAQPALPEGAEEGILKGMYRL-AAAAEA 732
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 725 GKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA--PAVAST 802
Cdd:PRK13012 733 PRVQLLGSGAILREVLAAARLLADDWGVDADVWSVTSFTELRRDGLAAERANLLGPAEEARVPYVTQCLAGTrgPVVAAT 812
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 803 DYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADKV 882
Cdd:PRK13012 813 DYVRAVPEQIRAFVPA-RYVTLGTDGFGRSDTRAALRRFFEVDRHSIVLAALKALADDGEVERTVVAEAIERYGIDDDKT 891
|
..
gi 476961654 883 NP 884
Cdd:PRK13012 892 PP 893
|
|
| AKGDH_not_PDH |
TIGR03186 |
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ... |
4-884 |
0e+00 |
|
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain] Cd Length: 889 Bit Score: 1139.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 4 RFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNvAAGTGISNYINTIPVEEQPEYPGNLELERRIR 83
Cdd:TIGR03186 1 RRHDDTDPQETAEWLDALDGVVAHAGAERAQYLLAQLAAHAARLGLA-PPAAGATPYVNTIAVDQEPPYPGDLQLEERLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 84 SAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQL 163
Cdd:TIGR03186 80 AILRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRAAGDASGGDLVYFQPHSAPGVYARAFLEGFLSDAQL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 164 DNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAI 243
Cdd:TIGR03186 160 AHYRQEIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLARTEGRKVWGFFGDGEMDEPESIGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 244 TIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDY 323
Cdd:TIGR03186 240 SLAARERLDNLVFVINCNLQRLDGPVRGNGRIIDELESQFAGAGWNVIKVLWGSDWDALFARDATGALARAFAHTVDGQF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 324 QTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEG 403
Cdd:TIGR03186 320 QTFSANDGAYNRARFFGQDPALAALVAHLSDEDIDRLRRGGHDARKLYAAYDRAVRHEGRPTVILAKTMKGFGMGAIGQG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 404 KNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFTEKLELPSLQDFG 483
Cdd:TIGR03186 400 RMTTHQQKKLDVEALLAFRDRFRLPLSDADVEQLKFYKPDEDSAEMRYLHARRAALGGYLPRRRTAATHALAVPALPSWG 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 484 AL-LEEQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEK 562
Cdd:TIGR03186 480 RFaLDAEGKEMSTTMAIVRMLGALLKDAELGPRIVPIVADEARTFGMANLFRQVGIYSPLGQRYEPEDLGSMLYYREDTD 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 563 GQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHE 642
Cdd:TIGR03186 560 GQILEEGISEAGAISSWIAAATSYSVHDLPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGKTTLGGEGLQHQ 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 643 DGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYgEKQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYK----LE 718
Cdd:TIGR03186 640 DGTSHLAASTVPNCRAWDPAFAYEVAVIVDEGMREML-ERQRDEFYYLTVTNENYAQPSLPEDRLDAVRRGILKgmypLD 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 719 TIEGSKGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVM--NDA 796
Cdd:TIGR03186 719 PAALAAARVQLLGSGAILGEVQAAARLLRDDWGIDAAVWSVTSFTELARDGRAAERAQRLGDAERPPSPHVAQALgaTQG 798
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 797 PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF- 875
Cdd:TIGR03186 799 PVIAATDYVRAVPELIRAYVPR-RYVTLGTDGFGRSDTRAALRAFFEVDRASIVIAALQALADDGLVARDVVRQAIARYg 877
|
....*....
gi 476961654 876 NIDADKVNP 884
Cdd:TIGR03186 878 KAATSRAPP 886
|
|
| TPP_E1_EcPDC_like |
cd02017 |
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ... |
76-461 |
0e+00 |
|
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain] Cd Length: 386 Bit Score: 748.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 76 LELERRIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLE 155
Cdd:cd02017 1 LEIERRIRSLIRWNAMAMVHRANKKDLGIGGHIATFASAATLYEVGFNHFFRARGEGGGGDLVYFQGHASPGIYARAFLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 156 GRLTQEQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMD 235
Cdd:cd02017 81 GRLTEEQLDNFRQEVGGGGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDRGLKDTSDQKVWAFLGDGEMD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 236 EPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLM 315
Cdd:cd02017 161 EPESLGAIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSKWDELLAKDGGGALRQRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 316 NETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGY 395
Cdd:cd02017 241 EETVDGDYQTLKAKDGAYVREHFFGKYPELKALVTDLSDEDLWALNRGGHDPRKVYAAYKKAVEHKGKPTVILAKTIKGY 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 476961654 396 GMGDAAEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHG 461
Cdd:cd02017 321 GLGAAGEGRNHAHQVKKMTEDELKALRDRFGIPVSDEQLEEGPYYKPPEGSEEIKYLHERRHALGG 386
|
|
| PDH_E1_M |
pfam17831 |
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ... |
474-700 |
2.21e-107 |
|
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain] Cd Length: 229 Bit Score: 330.54 E-value: 2.21e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 474 LELPSLQD--FGALLE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQD 550
Cdd:pfam17831 1 LEIPDLDDkiFASQTGgSKGREISTTMAFVRILNGLVKDKKIGKQVVPIIPDEARTFGMEGMFRQLGIYTSEGQKYEPVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 551 REQVAYYKEDEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSG 630
Cdd:pfam17831 81 KGQIMFYREDKQGQILEEGISEAGAMSAWIAAATSYSNHNTTLLPFYVYYSMFGFQRIGDLAWAAGDMQARGFLVGGTAG 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 631 RTTLNGEGLQHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEKqENVYYYITTLNENYHMP 700
Cdd:pfam17831 161 RTTLNGEGLQHQDGHSHIQASTIPNCRSYDPTYAHEVAVIVQDGLKRMFADK-ENCFYYLTVMNENYEHP 229
|
|
| TPP_TK |
cd02012 |
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ... |
85-408 |
4.92e-24 |
|
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain] Cd Length: 255 Bit Score: 102.20 E-value: 4.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 85 AIRWNAIMTVLRASkkdlelGGHMASFQSSATIYDVCFNHFFRARNEQ---DGGDlvYF---QGHISPGVYARAFLEGRL 158
Cdd:cd02012 2 RIRRLSIDMVQKAG------SGHPGGSLSAADILAVLYFKVLKYDPADpkwPNRD--RFvlsKGHASPALYAVLALAGYL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 159 TQEQLDNFRQevhgNGlSSYP-HPklmpEFWQFPTVSMGLGP--------IGAIYQAKFLKylehrglkdtSKQTVYAFL 229
Cdd:cd02012 74 PEEDLKTFRQ----LG-SRLPgHP----EYGLTPGVEVTTGSlgqglsvaVGMALAEKLLG----------FDYRVYVLL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 230 GDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPvTGNGKIINELEGIFEGAGWNVIKVmwgsrwdellrkdtsg 309
Cdd:cd02012 135 GDGELQEGSVWEAASFAGHYKLDNLIAIVDSNRIQIDGP-TDDILFTEDLAKKFEAFGWNVIEV---------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 310 kliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrGGHDPKKIYAAFKKAQETKGKATVILA 389
Cdd:cd02012 198 -----------------------------------------------------DGHDVEEILAALEEAKKSKGKPTLIIA 224
|
330
....*....|....*....
gi 476961654 390 HTIKGYGMgDAAEGKNIAH 408
Cdd:cd02012 225 KTIKGKGV-PFMENTAKWH 242
|
|
| PRK05899 |
PRK05899 |
transketolase; Reviewed |
75-408 |
7.52e-17 |
|
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain] Cd Length: 586 Bit Score: 84.80 E-value: 7.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 75 NLELERRIRSAIRWNAIMTVLRASkkdlelGGHMASFQSSATIYDVCFNHFFR--ARNEQDGG-D-LVYFQGHISPGVYA 150
Cdd:PRK05899 4 DMELLQLLANAIRVLSIDAVQKAN------SGHPGMPMGAADIAYVLWTRFLRhdPKNPKWPNrDrFVLSAGHGSMLLYS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 151 RAFLEG-RLTQEQLDNFRQevHGnglSSYP-HPklmpEFWQFPTVSMGLGPIG-----AIYQAKFLKYLEHRGLKDTSKQ 223
Cdd:PRK05899 78 LLHLAGyDLSIDDLKNFRQ--LG---SKTPgHP----EYGHTPGVETTTGPLGqglanAVGMALAEKYLAALFNRPGLDI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 224 T---VYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCN-LQrLDGPVTGngkIINE-LEGIFEGAGWNVIKVmwgsr 298
Cdd:PRK05899 149 VdhyTYVLCGDGDLMEGISHEACSLAGHLKLGNLIVIYDDNrIS-IDGPTEG---WFTEdVKKRFEAYGWHVIEV----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 299 wDellrkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrgGHDPKKIYAAFKKAQ 378
Cdd:PRK05899 220 -D---------------------------------------------------------------GHDVEAIDAAIEEAK 235
|
330 340 350
....*....|....*....|....*....|
gi 476961654 379 ETKgKATVILAHTIKGYGMGDaAEGKNIAH 408
Cdd:PRK05899 236 AST-KPTLIIAKTIIGKGAPN-KEGTHKVH 263
|
|
| Transketolase_N |
pfam00456 |
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ... |
79-408 |
1.19e-09 |
|
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain] Cd Length: 334 Bit Score: 60.86 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 79 ERRIRSAIRWNAIMTVLRASkkdlelGGHMASFQSSATIYDVCFNHFFR----ARNEQDGGDLVYFQGHISPGVYARAFL 154
Cdd:pfam00456 2 DKRAVNAIRALAMDAVEKAN------SGHPGAPMGMAPIAEVLFKRFLKhnpnDPKWINRDRFVLSNGHGSMLLYSLLHL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 155 EG-RLTQEQLDNFRQeVHgnglSSYP-HPklmpEFWQFPTVSMGLGPIG---------AIYQAKFLKYLEHRGLkDTSKQ 223
Cdd:pfam00456 76 TGyDLSMEDLKSFRQ-LG----SKTPgHP----EFGHTAGVEVTTGPLGqgianavgmAIAERNLAATYNRPGF-DIVDH 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 224 TVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVtgNGKIINELEGIFEGAGWNVIKVmwgsrwdell 303
Cdd:pfam00456 146 YTYVFLGDGCLMEGVSSEASSLAGHLGLGNLIVFYDDNQISIDGET--KISFTEDTAARFEAYGWHVIEV---------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 304 rkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnRGGHDPKKIYAAFKKAQETKGK 383
Cdd:pfam00456 214 ----------------------------------------------------------EDGHDVEAIAAAIEEAKAEKDK 235
|
330 340
....*....|....*....|....*
gi 476961654 384 ATVILAHTIKGYGmGDAAEGKNIAH 408
Cdd:pfam00456 236 PTLIKCRTVIGYG-SPNKQGTHDVH 259
|
|
| TktA |
COG0021 |
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ... |
225-408 |
4.44e-06 |
|
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439792 [Multi-domain] Cd Length: 661 Bit Score: 50.39 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 225 VYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGngkIINE-LEGIFEGAGWNVIKVMWGsrwdell 303
Cdd:COG0021 149 TYVIAGDGDLMEGISHEAASLAGHLKLGKLIVLYDDNGISIDGDTDL---AFSEdVAKRFEAYGWHVIRVEDG------- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 304 rkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrggHDPKKIYAAFKKAQETKGK 383
Cdd:COG0021 219 -------------------------------------------------------------HDLEAIDAAIEAAKAETDK 237
|
170 180
....*....|....*....|....*
gi 476961654 384 ATVILAHTIKGYGMGDAAeGKNIAH 408
Cdd:COG0021 238 PTLIICKTIIGYGSPNKQ-GTAKAH 261
|
|
| PTZ00089 |
PTZ00089 |
transketolase; Provisional |
142-293 |
3.75e-05 |
|
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain] Cd Length: 661 Bit Score: 47.36 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 142 GHISPGVYARAFLEGR-LTQEQLDNFRQEVhgnglSSYP-HPklmpEFWQFPTVSMGLGPIG-AIYQAKFLKYLEH---- 214
Cdd:PTZ00089 67 GHASALLYSMLHLTGYdLSMEDLKNFRQLG-----SRTPgHP----ERHITPGVEVTTGPLGqGIANAVGLAIAEKhlaa 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 215 ---RGLKDTSKQTVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVtgngkIINELEGI---FEGAGW 288
Cdd:PTZ00089 138 kfnRPGHPIFDNYVYVICGDGCLQEGVSQEALSLAGHLGLEKLIVLYDDNKITIDGNT-----DLSFTEDVekkYEAYGW 212
|
....*
gi 476961654 289 NVIKV 293
Cdd:PTZ00089 213 HVIEV 217
|
|
| TPP_enzymes |
cd00568 |
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ... |
178-305 |
1.71e-04 |
|
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain] Cd Length: 168 Bit Score: 43.01 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 178 YPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKylehrglkdtsKQTVYAFLGDGEMDepESKGAITIATREKLdNLVFV 257
Cdd:cd00568 31 LPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAP-----------DRPVVCIAGDGGFM--MTGQELATAVRYGL-PVIVV 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 476961654 258 INCN--------LQRLDGPVTGNGKIINE--LEGIFEGAGWNVIKVMWGSRWDELLRK 305
Cdd:cd00568 97 VFNNggygtirmHQEAFYGGRVSGTDLSNpdFAALAEAYGAKGVRVEDPEDLEAALAE 154
|
|
| PLN02790 |
PLN02790 |
transketolase |
142-749 |
6.01e-04 |
|
transketolase
Pssm-ID: 215424 [Multi-domain] Cd Length: 654 Bit Score: 43.47 E-value: 6.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 142 GHISPGVYARAFLEG--RLTQEQLDNFRQevHGnglSSYP-HPklmpEFWQFPTVSMGLGPIG-----AIYQAKFLKYLE 213
Cdd:PLN02790 55 GHGCMLQYALLHLAGydSVQMEDLKQFRQ--WG---SRTPgHP----ENFETPGIEVTTGPLGqgianAVGLALAEKHLA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 214 HRGLKDTSK---QTVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVTgngkiINELEGI---FEGAG 287
Cdd:PLN02790 126 ARFNKPDHKivdHYTYCILGDGCQMEGISNEAASLAGHWGLGKLIVLYDDNHISIDGDTE-----IAFTEDVdkrYEALG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 288 WNVIkvmwgsrwdellrkdtsgkliqlmneTVDGdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrGGHDP 367
Cdd:PLN02790 201 WHTI--------------------------WVKN-----------------------------------------GNTDY 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 368 KKIYAAFKKAQETKGKATVILAHTIKGYGM----------GDAAEGKNIAHQVKKMNMDgvrhiRDRFNVP--VSD---- 431
Cdd:PLN02790 214 DEIRAAIKEAKAVTDKPTLIKVTTTIGYGSpnkansysvhGAALGEKEVDATRKNLGWP-----YEPFHVPedVKShwsk 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 432 -----ADIEKLPYITFPEGSEEHTYLHAQ-RQKLHGYLPSRQ----PNFTEKlelpslqdfgalleeqSKEISTTIAFVR 501
Cdd:PLN02790 289 htkegAALEAEWNAKFAEYKKKYPEEAAElKSLISGELPSGWekalPTFTPE----------------DPADATRNLSQK 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 502 ALNVMLKnksikdrLVP-II---ADEA---RTfgmegLFRQIGiyspNGQQYTPQDREqvayykedekgqiLQEGINE-- 572
Cdd:PLN02790 353 CLNALAK-------VLPgLIggsADLAssnMT-----LLKDFG----DFQKDTPEERN-------------VRFGVREhg 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 573 LGAGCSWLAAatsystNNLPMIP----FYIY--YsMFGFQRIGDLCWAagdqqargfligGTSGRTTLNGEGLQhEDGHS 646
Cdd:PLN02790 404 MGAICNGIAL------HSSGLIPycatFFVFtdY-MRAAMRLSALSEA------------GVIYVMTHDSIGLG-EDGPT 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 647 H--IQSL----TIPNCISYDPAYAYEVAVIMHDGLERMYGEkqenvyyyiTTLN-ENYHMPAMPEGAEEGIRKGIYKL-E 718
Cdd:PLN02790 464 HqpIEHLaslrAMPNILMLRPADGNETAGAYKVAVTNRKRP---------TVLAlSRQKVPNLPGTSIEGVEKGGYVIsD 534
|
650 660 670
....*....|....*....|....*....|.
gi 476961654 719 TIEGSKGKVQLLGSGSILRHVREAAEILAKD 749
Cdd:PLN02790 535 NSSGNKPDLILIGTGSELEIAAKAAKELRKE 565
|
|
|