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Conserved domains on  [gi|476961654|gb|ENC49693|]
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pyruvate dehydrogenase (acetyl-transferring), homodimeric type [Escherichia coli P0299917.2]

Protein Classification

pyruvate dehydrogenase (acetyl-transferring), homodimeric type( domain architecture ID 11484099)

E1 component of the acetyl-transferring homodimeric-type pyruvate dehydrogenase multienzyme complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2

CATH:  4.10.320.10
EC:  1.2.4.1
Gene Ontology:  GO:0004739|GO:0006096
PubMed:  17635929|11955070
SCOP:  3001183

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
aceE PRK09405
pyruvate dehydrogenase subunit E1; Reviewed
1-887 0e+00

pyruvate dehydrogenase subunit E1; Reviewed


:

Pssm-ID: 236500 [Multi-domain]  Cd Length: 891  Bit Score: 1958.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   1 MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELER 80
Cdd:PRK09405   4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASA-TTPYINTIPVEEEPEYPGDLELER 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  81 RIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQ 160
Cdd:PRK09405  83 RIRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 161 EQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESK 240
Cdd:PRK09405 163 EQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 241 GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVD 320
Cdd:PRK09405 243 GAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVD 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 321 GDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDA 400
Cdd:PRK09405 323 GDYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 401 AEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFtEKLELPSLQ 480
Cdd:PRK09405 403 GEGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALS 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 481 DFGALLEEQSK-EISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKE 559
Cdd:PRK09405 482 AFEALLKGSGErEISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKE 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 560 DEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGL 639
Cdd:PRK09405 562 SKDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGL 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 640 QHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLET 719
Cdd:PRK09405 642 QHEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLET 720
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 720 IEGSKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA- 796
Cdd:PRK09405 721 AEGKKGKpkVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGAe 800
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 797 -PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF 875
Cdd:PRK09405 801 gPVVAATDYMKLFAEQIRAFVPG-DYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKY 879
                        890
                 ....*....|..
gi 476961654 876 NIDADKVNPRLA 887
Cdd:PRK09405 880 GIDPDKANPRTA 891
 
Name Accession Description Interval E-value
aceE PRK09405
pyruvate dehydrogenase subunit E1; Reviewed
1-887 0e+00

pyruvate dehydrogenase subunit E1; Reviewed


Pssm-ID: 236500 [Multi-domain]  Cd Length: 891  Bit Score: 1958.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   1 MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELER 80
Cdd:PRK09405   4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASA-TTPYINTIPVEEEPEYPGDLELER 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  81 RIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQ 160
Cdd:PRK09405  83 RIRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 161 EQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESK 240
Cdd:PRK09405 163 EQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 241 GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVD 320
Cdd:PRK09405 243 GAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVD 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 321 GDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDA 400
Cdd:PRK09405 323 GDYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 401 AEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFtEKLELPSLQ 480
Cdd:PRK09405 403 GEGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALS 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 481 DFGALLEEQSK-EISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKE 559
Cdd:PRK09405 482 AFEALLKGSGErEISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKE 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 560 DEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGL 639
Cdd:PRK09405 562 SKDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGL 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 640 QHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLET 719
Cdd:PRK09405 642 QHEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLET 720
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 720 IEGSKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA- 796
Cdd:PRK09405 721 AEGKKGKpkVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGAe 800
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 797 -PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF 875
Cdd:PRK09405 801 gPVVAATDYMKLFAEQIRAFVPG-DYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKY 879
                        890
                 ....*....|..
gi 476961654 876 NIDADKVNPRLA 887
Cdd:PRK09405 880 GIDPDKANPRTA 891
AceE COG2609
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
6-887 0e+00

Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 442021 [Multi-domain]  Cd Length: 891  Bit Score: 1915.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   6 PNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIRSA 85
Cdd:COG2609   10 LPDIDPQETQEWLESLDAVIEEEGPERARYLLERLLERARRSGVGLPFSA-TTPYINTIPVEQEPPYPGDEELERRIRSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  86 IRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDN 165
Cdd:COG2609   89 IRWNAMAMVVRANRKGGGLGGHISSFASAATLYEVGFNHFFRGPDHPGGGDLVYFQGHASPGIYARAFLEGRLTEEQLDN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 166 FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITI 245
Cdd:COG2609  169 FRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLHNRGLKDTSDRKVWAFLGDGEMDEPESLGAISL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 246 ATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQT 325
Cdd:COG2609  249 AAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAGWNVIKVIWGSEWDPLLAKDTDGALVKRMNETVDGDYQT 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 326 FKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKN 405
Cdd:COG2609  329 YKAKDGAYVREHFFGKYPELKALVADMSDEDIWRLNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEAGEGRN 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 406 IAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNfTEKLELPSLQDFGAL 485
Cdd:COG2609  409 ITHQQKKLDLDDLKAFRDRFNIPISDEQLEELPYYKPAEDSPEMKYLHERRKALGGYLPQRRTK-AEPLEVPELSAFAAL 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 486 LE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQ 564
Cdd:COG2609  488 LKgSGKREISTTMAFVRILNDLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPVGQLYTPVDADQLLYYKESKDGQ 567
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 565 ILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDG 644
Cdd:COG2609  568 ILQEGINEAGAMSSWIAAGTSYSTHGVPMIPFYIYYSMFGFQRVGDLAWAAGDQRARGFLIGATAGRTTLNGEGLQHQDG 647
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 645 HSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG-S 723
Cdd:COG2609  648 HSHLLASTIPNCVSYDPAFAYELAVIVQDGLRRMYGE-QENVFYYITVMNENYAQPAMPEGVEEGILKGMYLLKEGEGkG 726
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 724 KGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA--PAVAS 801
Cdd:COG2609  727 KPRVQLLGSGTILREVLAAAELLAEDWGVAADVWSVTSFNELRRDGLDVERWNLLHPEEEPRVPYVTQCLAGAegPVVAA 806
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 802 TDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADK 881
Cdd:COG2609  807 TDYMRAVPDQIRPWVPG-RYTVLGTDGFGRSDTREALRRFFEVDRYSIVVAALKALADEGKIDASVVAEAIKKYGIDPDK 885

                 ....*.
gi 476961654 882 VNPRLA 887
Cdd:COG2609  886 PNPLTA 891
aceE TIGR00759
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
4-887 0e+00

pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.


Pssm-ID: 273255 [Multi-domain]  Cd Length: 885  Bit Score: 1712.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654    4 RFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIR 83
Cdd:TIGR00759   1 SQPNDVDPIETQEWLESLDSVLAEEGPARARYLLEQLLEYAREHGVPIPAGT-TTDYINTIPVEEQPAYPGDLELERRIR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   84 SAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQL 163
Cdd:TIGR00759  80 SIIRWNAIAMVLRANKKDLGLGGHISTYASAATLYEVGFNHFFRGHSEGGGGDLVFFQGHAAPGIYARAFLEGRLTEEQL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  164 DNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAI 243
Cdd:TIGR00759 160 DNFRQEVQGDGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLENRGLKDTGDQKVWAFLGDGEMDEPESKGAI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  244 TIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDY 323
Cdd:TIGR00759 240 TFAAREKLDNLTFVINCNLQRLDGPVRGNGKIIQELESLFRGAGWNVIKVLWGSEWDALLARDTSGVLVKLMNETVDGDY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  324 QTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEG 403
Cdd:TIGR00759 320 QTYKAKDGAYVREHFFNRTPELKALVADMSDADIWALNRGGHDPRKVYAAYAAAQEHKGQPTVILAKTIKGYGMGDAAES 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  404 KNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPnFTEKLELPSLQDFG 483
Cdd:TIGR00759 400 RNTAHQVKKLEVDALKNFRDRFELPLSDAQVEELPYYHPGEGSPEVRYLLARRQALGGYLPARRT-FAEHLTVPALEFFG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  484 ALLEEQS-KEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEK 562
Cdd:TIGR00759 479 ALLKGSGeREVSTTMAFVRILNKLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPHGQTYTPVDADSLLAYKESKD 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  563 GQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINEAGAMASWIAAATSYATHGEPMIPFYIYYSMFGFQRIGDLCWAAADQRARGFLLGATAGRTTLNGEGLQHE 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  643 DGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG 722
Cdd:TIGR00759 639 DGHSLLQAATIPNCIAYDPAFAYEVAVIMEDGLRRMYGE-QEDVFYYVTVMNENYVQPPMPEGAEEGILKGLYRFETSTE 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  723 SKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMN--DAPA 798
Cdd:TIGR00759 718 EKAKghVQLLGSGAIMRAVIEAAQLLAADWGVASDVWSVTSFTELARDGHDVERWNLLHPTETPRVSYVAQVLNeaDAPV 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  799 VASTDYMKLFAEQVRTYVPaDDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNID 878
Cdd:TIGR00759 798 IASTDYVRAFAEQIRPYVP-RKYVTLGTDGFGRSDTRENLRHFFEVDAKSVVLAALYALADDGEIDGDVVADAIAKYGID 876

                  ....*....
gi 476961654  879 ADKVNPRLA 887
Cdd:TIGR00759 877 PDKANPVYR 885
TPP_E1_EcPDC_like cd02017
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
76-461 0e+00

Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.


Pssm-ID: 238975 [Multi-domain]  Cd Length: 386  Bit Score: 748.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  76 LELERRIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLE 155
Cdd:cd02017    1 LEIERRIRSLIRWNAMAMVHRANKKDLGIGGHIATFASAATLYEVGFNHFFRARGEGGGGDLVYFQGHASPGIYARAFLE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 156 GRLTQEQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMD 235
Cdd:cd02017   81 GRLTEEQLDNFRQEVGGGGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDRGLKDTSDQKVWAFLGDGEMD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 236 EPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLM 315
Cdd:cd02017  161 EPESLGAIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSKWDELLAKDGGGALRQRM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 316 NETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGY 395
Cdd:cd02017  241 EETVDGDYQTLKAKDGAYVREHFFGKYPELKALVTDLSDEDLWALNRGGHDPRKVYAAYKKAVEHKGKPTVILAKTIKGY 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 476961654 396 GMGDAAEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHG 461
Cdd:cd02017  321 GLGAAGEGRNHAHQVKKMTEDELKALRDRFGIPVSDEQLEEGPYYKPPEGSEEIKYLHERRHALGG 386
PDH_E1_M pfam17831
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
474-700 2.21e-107

Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.


Pssm-ID: 465525 [Multi-domain]  Cd Length: 229  Bit Score: 330.54  E-value: 2.21e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  474 LELPSLQD--FGALLE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQD 550
Cdd:pfam17831   1 LEIPDLDDkiFASQTGgSKGREISTTMAFVRILNGLVKDKKIGKQVVPIIPDEARTFGMEGMFRQLGIYTSEGQKYEPVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  551 REQVAYYKEDEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSG 630
Cdd:pfam17831  81 KGQIMFYREDKQGQILEEGISEAGAMSAWIAAATSYSNHNTTLLPFYVYYSMFGFQRIGDLAWAAGDMQARGFLVGGTAG 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  631 RTTLNGEGLQHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEKqENVYYYITTLNENYHMP 700
Cdd:pfam17831 161 RTTLNGEGLQHQDGHSHIQASTIPNCRSYDPTYAHEVAVIVQDGLKRMFADK-ENCFYYLTVMNENYEHP 229
 
Name Accession Description Interval E-value
aceE PRK09405
pyruvate dehydrogenase subunit E1; Reviewed
1-887 0e+00

pyruvate dehydrogenase subunit E1; Reviewed


Pssm-ID: 236500 [Multi-domain]  Cd Length: 891  Bit Score: 1958.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   1 MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELER 80
Cdd:PRK09405   4 GSESQLNDIDPIETQEWLEALDSVIREEGPERAHYLLEQLLERAREKGVSLPASA-TTPYINTIPVEEEPEYPGDLELER 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  81 RIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQ 160
Cdd:PRK09405  83 RIRSYIRWNAAAMVLRANKKDLGLGGHISSFASSATLYEVGFNHFFRAPNEPHGGDLVFFQGHASPGIYARAFLEGRLTE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 161 EQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESK 240
Cdd:PRK09405 163 EQLDNFRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFLKYLENRGLKDTSDQKVWAFLGDGEMDEPESL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 241 GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVD 320
Cdd:PRK09405 243 GAISLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSRWDPLLAKDTSGKLVQLMNETVD 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 321 GDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDA 400
Cdd:PRK09405 323 GDYQTYKAKDGAYVREHFFGKYPETKALVADMSDDDIWALNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEA 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 401 AEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFtEKLELPSLQ 480
Cdd:PRK09405 403 GEGKNIAHQVKKLDLDDLKHFRDRFNIPISDEQLEKLPYYKPGEDSPEIKYLHERRKALGGYLPARRPKF-EPLEVPALS 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 481 DFGALLEEQSK-EISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKE 559
Cdd:PRK09405 482 AFEALLKGSGErEISTTMAFVRILNILLKDKEIGKRIVPIIPDEARTFGMEGLFRQIGIYNPHGQLYTPVDRDQLMYYKE 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 560 DEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGL 639
Cdd:PRK09405 562 SKDGQILQEGINEAGAMASWIAAATSYSTHGEPMIPFYIYYSMFGFQRIGDLAWAAGDQRARGFLLGGTAGRTTLNGEGL 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 640 QHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLET 719
Cdd:PRK09405 642 QHEDGHSHILASTIPNCVSYDPAFAYEVAVIVQDGLRRMYGE-QENVFYYITVMNENYHQPAMPEGAEEGILKGMYKLET 720
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 720 IEGSKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA- 796
Cdd:PRK09405 721 AEGKKGKpkVQLLGSGTILREVLEAAEILAEDYGVAADVWSVTSFNELARDGQDVERWNMLHPTEEPRVPYVTQVLKGAe 800
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 797 -PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF 875
Cdd:PRK09405 801 gPVVAATDYMKLFAEQIRAFVPG-DYVVLGTDGFGRSDTREALRRFFEVDAEYVVVAALKALADEGEIDASVVAEAIKKY 879
                        890
                 ....*....|..
gi 476961654 876 NIDADKVNPRLA 887
Cdd:PRK09405 880 GIDPDKANPRTA 891
AceE COG2609
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
6-887 0e+00

Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 442021 [Multi-domain]  Cd Length: 891  Bit Score: 1915.98  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   6 PNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIRSA 85
Cdd:COG2609   10 LPDIDPQETQEWLESLDAVIEEEGPERARYLLERLLERARRSGVGLPFSA-TTPYINTIPVEQEPPYPGDEELERRIRSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  86 IRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDN 165
Cdd:COG2609   89 IRWNAMAMVVRANRKGGGLGGHISSFASAATLYEVGFNHFFRGPDHPGGGDLVYFQGHASPGIYARAFLEGRLTEEQLDN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 166 FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITI 245
Cdd:COG2609  169 FRQEVDGKGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLHNRGLKDTSDRKVWAFLGDGEMDEPESLGAISL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 246 ATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQT 325
Cdd:COG2609  249 AAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGVFRGAGWNVIKVIWGSEWDPLLAKDTDGALVKRMNETVDGDYQT 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 326 FKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKN 405
Cdd:COG2609  329 YKAKDGAYVREHFFGKYPELKALVADMSDEDIWRLNRGGHDPRKVYAAYKAAVEHKGQPTVILAKTIKGYGMGEAGEGRN 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 406 IAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNfTEKLELPSLQDFGAL 485
Cdd:COG2609  409 ITHQQKKLDLDDLKAFRDRFNIPISDEQLEELPYYKPAEDSPEMKYLHERRKALGGYLPQRRTK-AEPLEVPELSAFAAL 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 486 LE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQ 564
Cdd:COG2609  488 LKgSGKREISTTMAFVRILNDLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPVGQLYTPVDADQLLYYKESKDGQ 567
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 565 ILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDG 644
Cdd:COG2609  568 ILQEGINEAGAMSSWIAAGTSYSTHGVPMIPFYIYYSMFGFQRVGDLAWAAGDQRARGFLIGATAGRTTLNGEGLQHQDG 647
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 645 HSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG-S 723
Cdd:COG2609  648 HSHLLASTIPNCVSYDPAFAYELAVIVQDGLRRMYGE-QENVFYYITVMNENYAQPAMPEGVEEGILKGMYLLKEGEGkG 726
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 724 KGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA--PAVAS 801
Cdd:COG2609  727 KPRVQLLGSGTILREVLAAAELLAEDWGVAADVWSVTSFNELRRDGLDVERWNLLHPEEEPRVPYVTQCLAGAegPVVAA 806
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 802 TDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADK 881
Cdd:COG2609  807 TDYMRAVPDQIRPWVPG-RYTVLGTDGFGRSDTREALRRFFEVDRYSIVVAALKALADEGKIDASVVAEAIKKYGIDPDK 885

                 ....*.
gi 476961654 882 VNPRLA 887
Cdd:COG2609  886 PNPLTA 891
aceE TIGR00759
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
4-887 0e+00

pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.


Pssm-ID: 273255 [Multi-domain]  Cd Length: 885  Bit Score: 1712.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654    4 RFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTgISNYINTIPVEEQPEYPGNLELERRIR 83
Cdd:TIGR00759   1 SQPNDVDPIETQEWLESLDSVLAEEGPARARYLLEQLLEYAREHGVPIPAGT-TTDYINTIPVEEQPAYPGDLELERRIR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   84 SAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQL 163
Cdd:TIGR00759  80 SIIRWNAIAMVLRANKKDLGLGGHISTYASAATLYEVGFNHFFRGHSEGGGGDLVFFQGHAAPGIYARAFLEGRLTEEQL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  164 DNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAI 243
Cdd:TIGR00759 160 DNFRQEVQGDGLSSYPHPWLMPDFWQFPTVSMGLGPINAIYQARFMKYLENRGLKDTGDQKVWAFLGDGEMDEPESKGAI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  244 TIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDY 323
Cdd:TIGR00759 240 TFAAREKLDNLTFVINCNLQRLDGPVRGNGKIIQELESLFRGAGWNVIKVLWGSEWDALLARDTSGVLVKLMNETVDGDY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  324 QTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEG 403
Cdd:TIGR00759 320 QTYKAKDGAYVREHFFNRTPELKALVADMSDADIWALNRGGHDPRKVYAAYAAAQEHKGQPTVILAKTIKGYGMGDAAES 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  404 KNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPnFTEKLELPSLQDFG 483
Cdd:TIGR00759 400 RNTAHQVKKLEVDALKNFRDRFELPLSDAQVEELPYYHPGEGSPEVRYLLARRQALGGYLPARRT-FAEHLTVPALEFFG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  484 ALLEEQS-KEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEK 562
Cdd:TIGR00759 479 ALLKGSGeREVSTTMAFVRILNKLLKDKEIGKRIVPIVPDEARTFGMEGLFRQIGIYSPHGQTYTPVDADSLLAYKESKD 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  563 GQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINEAGAMASWIAAATSYATHGEPMIPFYIYYSMFGFQRIGDLCWAAADQRARGFLLGATAGRTTLNGEGLQHE 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  643 DGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETIEG 722
Cdd:TIGR00759 639 DGHSLLQAATIPNCIAYDPAFAYEVAVIMEDGLRRMYGE-QEDVFYYVTVMNENYVQPPMPEGAEEGILKGLYRFETSTE 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  723 SKGK--VQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMN--DAPA 798
Cdd:TIGR00759 718 EKAKghVQLLGSGAIMRAVIEAAQLLAADWGVASDVWSVTSFTELARDGHDVERWNLLHPTETPRVSYVAQVLNeaDAPV 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  799 VASTDYMKLFAEQVRTYVPaDDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNID 878
Cdd:TIGR00759 798 IASTDYVRAFAEQIRPYVP-RKYVTLGTDGFGRSDTRENLRHFFEVDAKSVVLAALYALADDGEIDGDVVADAIAKYGID 876

                  ....*....
gi 476961654  879 ADKVNPRLA 887
Cdd:TIGR00759 877 PDKANPVYR 885
PRK13012 PRK13012
2-oxoacid dehydrogenase subunit E1; Provisional
6-884 0e+00

2-oxoacid dehydrogenase subunit E1; Provisional


Pssm-ID: 237267 [Multi-domain]  Cd Length: 896  Bit Score: 1517.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   6 PNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTGiSNYINTIPVEEQPEYPGNLELERRIRSA 85
Cdd:PRK13012  17 LPDIDPQETAEWLEALDAVVAHAGPERARYLLDRLLERAAARGIALPGLLT-TPYVNTIPVDQQPPYPGDLALEERLAAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  86 IRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDN 165
Cdd:PRK13012  96 IRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRGRDDAGGGDLVYFQPHSAPGIYARAFLEGRLSEEQLDH 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 166 FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAITI 245
Cdd:PRK13012 176 FRQEIGGPGLSSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQHRGLKDTSGRKVWGFFGDGEMDEPESIAALSL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 246 ATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDYQT 325
Cdd:PRK13012 256 AAREGLDNLVFVINCNLQRLDGPVRGNGRIIQELEALFRGAGWNVIKVLWGSDWDALFARDTTGALVRRFAETVDGQFQT 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 326 FKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKN 405
Cdd:PRK13012 336 FKANDGAYNREHFFGQDPELAALVAHLSDEDIDRLKRGGHDPRKVYAAYAAAVRHKGQPTVILAKTKKGYGMGEAGEGRM 415
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 406 IAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNfTEKLELPSLQDFGA- 484
Cdd:PRK13012 416 TTHQQKKLDVEALKAFRDRFRLPLSDEQLEQLPFYKPAEDSPEMRYLHARRAALGGYLPRRRTA-APPLPVPPLSAFAQf 494
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 485 LLEEQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEKGQ 564
Cdd:PRK13012 495 ALGAGGKEMSTTMAFVRMLGNLLKDKALGPRIVPIVADEARTFGMANLFRQVGIYSPLGQLYEPEDAGSLLYYREAKDGQ 574
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 565 ILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDG 644
Cdd:PRK13012 575 ILEEGITEAGAISSWIAAATSYSVHGLPMLPFYIYYSMFGFQRVGDLIWAAADQRARGFLLGATAGRTTLGGEGLQHQDG 654
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 645 HSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEkQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLeTIEGSK 724
Cdd:PRK13012 655 HSHLLASTIPNCRAYDPAFAYELAVIVDDGMRRMLEE-QEDVFYYLTVMNENYAQPALPEGAEEGILKGMYRL-AAAAEA 732
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 725 GKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVMNDA--PAVAST 802
Cdd:PRK13012 733 PRVQLLGSGAILREVLAAARLLADDWGVDADVWSVTSFTELRRDGLAAERANLLGPAEEARVPYVTQCLAGTrgPVVAAT 812
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 803 DYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADKV 882
Cdd:PRK13012 813 DYVRAVPEQIRAFVPA-RYVTLGTDGFGRSDTRAALRRFFEVDRHSIVLAALKALADDGEVERTVVAEAIERYGIDDDKT 891

                 ..
gi 476961654 883 NP 884
Cdd:PRK13012 892 PP 893
AKGDH_not_PDH TIGR03186
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
4-884 0e+00

alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.


Pssm-ID: 132230 [Multi-domain]  Cd Length: 889  Bit Score: 1139.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654    4 RFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNvAAGTGISNYINTIPVEEQPEYPGNLELERRIR 83
Cdd:TIGR03186   1 RRHDDTDPQETAEWLDALDGVVAHAGAERAQYLLAQLAAHAARLGLA-PPAAGATPYVNTIAVDQEPPYPGDLQLEERLA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   84 SAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQL 163
Cdd:TIGR03186  80 AILRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHFFRAAGDASGGDLVYFQPHSAPGVYARAFLEGFLSDAQL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  164 DNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESKGAI 243
Cdd:TIGR03186 160 AHYRQEIAGPGLCSYPHPWLMPDFWQFPTGSMGIGPINAIYQARFMRYLQNRGLARTEGRKVWGFFGDGEMDEPESIGAL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  244 TIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLMNETVDGDY 323
Cdd:TIGR03186 240 SLAARERLDNLVFVINCNLQRLDGPVRGNGRIIDELESQFAGAGWNVIKVLWGSDWDALFARDATGALARAFAHTVDGQF 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  324 QTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEG 403
Cdd:TIGR03186 320 QTFSANDGAYNRARFFGQDPALAALVAHLSDEDIDRLRRGGHDARKLYAAYDRAVRHEGRPTVILAKTMKGFGMGAIGQG 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  404 KNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFTEKLELPSLQDFG 483
Cdd:TIGR03186 400 RMTTHQQKKLDVEALLAFRDRFRLPLSDADVEQLKFYKPDEDSAEMRYLHARRAALGGYLPRRRTAATHALAVPALPSWG 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  484 AL-LEEQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQDREQVAYYKEDEK 562
Cdd:TIGR03186 480 RFaLDAEGKEMSTTMAIVRMLGALLKDAELGPRIVPIVADEARTFGMANLFRQVGIYSPLGQRYEPEDLGSMLYYREDTD 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  563 GQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHE 642
Cdd:TIGR03186 560 GQILEEGISEAGAISSWIAAATSYSVHDLPMLPFYIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGKTTLGGEGLQHQ 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  643 DGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYgEKQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYK----LE 718
Cdd:TIGR03186 640 DGTSHLAASTVPNCRAWDPAFAYEVAVIVDEGMREML-ERQRDEFYYLTVTNENYAQPSLPEDRLDAVRRGILKgmypLD 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  719 TIEGSKGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHPLETPRVPYIAQVM--NDA 796
Cdd:TIGR03186 719 PAALAAARVQLLGSGAILGEVQAAARLLRDDWGIDAAVWSVTSFTELARDGRAAERAQRLGDAERPPSPHVAQALgaTQG 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  797 PAVASTDYMKLFAEQVRTYVPAdDYRVLGTDGFGRSDSRENLRHHFEVDASYVVVAALGELAKRGEIDKKVVADAIAKF- 875
Cdd:TIGR03186 799 PVIAATDYVRAVPELIRAYVPR-RYVTLGTDGFGRSDTRAALRAFFEVDRASIVIAALQALADDGLVARDVVRQAIARYg 877

                  ....*....
gi 476961654  876 NIDADKVNP 884
Cdd:TIGR03186 878 KAATSRAPP 886
TPP_E1_EcPDC_like cd02017
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
76-461 0e+00

Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.


Pssm-ID: 238975 [Multi-domain]  Cd Length: 386  Bit Score: 748.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  76 LELERRIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDVCFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLE 155
Cdd:cd02017    1 LEIERRIRSLIRWNAMAMVHRANKKDLGIGGHIATFASAATLYEVGFNHFFRARGEGGGGDLVYFQGHASPGIYARAFLE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 156 GRLTQEQLDNFRQEVHGNGLSSYPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMD 235
Cdd:cd02017   81 GRLTEEQLDNFRQEVGGGGLSSYPHPWLMPDFWEFPTVSMGLGPIQAIYQARFNRYLEDRGLKDTSDQKVWAFLGDGEMD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 236 EPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWDELLRKDTSGKLIQLM 315
Cdd:cd02017  161 EPESLGAIGLAAREKLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGIFRGAGWNVIKVIWGSKWDELLAKDGGGALRQRM 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 316 NETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWALNRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGY 395
Cdd:cd02017  241 EETVDGDYQTLKAKDGAYVREHFFGKYPELKALVTDLSDEDLWALNRGGHDPRKVYAAYKKAVEHKGKPTVILAKTIKGY 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 476961654 396 GMGDAAEGKNIAHQVKKMNMDGVRHIRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHG 461
Cdd:cd02017  321 GLGAAGEGRNHAHQVKKMTEDELKALRDRFGIPVSDEQLEEGPYYKPPEGSEEIKYLHERRHALGG 386
PDH_E1_M pfam17831
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
474-700 2.21e-107

Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.


Pssm-ID: 465525 [Multi-domain]  Cd Length: 229  Bit Score: 330.54  E-value: 2.21e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  474 LELPSLQD--FGALLE-EQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYSPNGQQYTPQD 550
Cdd:pfam17831   1 LEIPDLDDkiFASQTGgSKGREISTTMAFVRILNGLVKDKKIGKQVVPIIPDEARTFGMEGMFRQLGIYTSEGQKYEPVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  551 REQVAYYKEDEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYYSMFGFQRIGDLCWAAGDQQARGFLIGGTSG 630
Cdd:pfam17831  81 KGQIMFYREDKQGQILEEGISEAGAMSAWIAAATSYSNHNTTLLPFYVYYSMFGFQRIGDLAWAAGDMQARGFLVGGTAG 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  631 RTTLNGEGLQHEDGHSHIQSLTIPNCISYDPAYAYEVAVIMHDGLERMYGEKqENVYYYITTLNENYHMP 700
Cdd:pfam17831 161 RTTLNGEGLQHQDGHSHIQASTIPNCRSYDPTYAHEVAVIVQDGLKRMFADK-ENCFYYLTVMNENYEHP 229
TPP_TK cd02012
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
85-408 4.92e-24

Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.


Pssm-ID: 238970 [Multi-domain]  Cd Length: 255  Bit Score: 102.20  E-value: 4.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  85 AIRWNAIMTVLRASkkdlelGGHMASFQSSATIYDVCFNHFFRARNEQ---DGGDlvYF---QGHISPGVYARAFLEGRL 158
Cdd:cd02012    2 RIRRLSIDMVQKAG------SGHPGGSLSAADILAVLYFKVLKYDPADpkwPNRD--RFvlsKGHASPALYAVLALAGYL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 159 TQEQLDNFRQevhgNGlSSYP-HPklmpEFWQFPTVSMGLGP--------IGAIYQAKFLKylehrglkdtSKQTVYAFL 229
Cdd:cd02012   74 PEEDLKTFRQ----LG-SRLPgHP----EYGLTPGVEVTTGSlgqglsvaVGMALAEKLLG----------FDYRVYVLL 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 230 GDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPvTGNGKIINELEGIFEGAGWNVIKVmwgsrwdellrkdtsg 309
Cdd:cd02012  135 GDGELQEGSVWEAASFAGHYKLDNLIAIVDSNRIQIDGP-TDDILFTEDLAKKFEAFGWNVIEV---------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 310 kliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrGGHDPKKIYAAFKKAQETKGKATVILA 389
Cdd:cd02012  198 -----------------------------------------------------DGHDVEEILAALEEAKKSKGKPTLIIA 224
                        330
                 ....*....|....*....
gi 476961654 390 HTIKGYGMgDAAEGKNIAH 408
Cdd:cd02012  225 KTIKGKGV-PFMENTAKWH 242
PRK05899 PRK05899
transketolase; Reviewed
75-408 7.52e-17

transketolase; Reviewed


Pssm-ID: 235639 [Multi-domain]  Cd Length: 586  Bit Score: 84.80  E-value: 7.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  75 NLELERRIRSAIRWNAIMTVLRASkkdlelGGHMASFQSSATIYDVCFNHFFR--ARNEQDGG-D-LVYFQGHISPGVYA 150
Cdd:PRK05899   4 DMELLQLLANAIRVLSIDAVQKAN------SGHPGMPMGAADIAYVLWTRFLRhdPKNPKWPNrDrFVLSAGHGSMLLYS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 151 RAFLEG-RLTQEQLDNFRQevHGnglSSYP-HPklmpEFWQFPTVSMGLGPIG-----AIYQAKFLKYLEHRGLKDTSKQ 223
Cdd:PRK05899  78 LLHLAGyDLSIDDLKNFRQ--LG---SKTPgHP----EYGHTPGVETTTGPLGqglanAVGMALAEKYLAALFNRPGLDI 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 224 T---VYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCN-LQrLDGPVTGngkIINE-LEGIFEGAGWNVIKVmwgsr 298
Cdd:PRK05899 149 VdhyTYVLCGDGDLMEGISHEACSLAGHLKLGNLIVIYDDNrIS-IDGPTEG---WFTEdVKKRFEAYGWHVIEV----- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 299 wDellrkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrgGHDPKKIYAAFKKAQ 378
Cdd:PRK05899 220 -D---------------------------------------------------------------GHDVEAIDAAIEEAK 235
                        330       340       350
                 ....*....|....*....|....*....|
gi 476961654 379 ETKgKATVILAHTIKGYGMGDaAEGKNIAH 408
Cdd:PRK05899 236 AST-KPTLIIAKTIIGKGAPN-KEGTHKVH 263
Transketolase_N pfam00456
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
79-408 1.19e-09

Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.


Pssm-ID: 395366 [Multi-domain]  Cd Length: 334  Bit Score: 60.86  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654   79 ERRIRSAIRWNAIMTVLRASkkdlelGGHMASFQSSATIYDVCFNHFFR----ARNEQDGGDLVYFQGHISPGVYARAFL 154
Cdd:pfam00456   2 DKRAVNAIRALAMDAVEKAN------SGHPGAPMGMAPIAEVLFKRFLKhnpnDPKWINRDRFVLSNGHGSMLLYSLLHL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  155 EG-RLTQEQLDNFRQeVHgnglSSYP-HPklmpEFWQFPTVSMGLGPIG---------AIYQAKFLKYLEHRGLkDTSKQ 223
Cdd:pfam00456  76 TGyDLSMEDLKSFRQ-LG----SKTPgHP----EFGHTAGVEVTTGPLGqgianavgmAIAERNLAATYNRPGF-DIVDH 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  224 TVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVtgNGKIINELEGIFEGAGWNVIKVmwgsrwdell 303
Cdd:pfam00456 146 YTYVFLGDGCLMEGVSSEASSLAGHLGLGNLIVFYDDNQISIDGET--KISFTEDTAARFEAYGWHVIEV---------- 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654  304 rkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnRGGHDPKKIYAAFKKAQETKGK 383
Cdd:pfam00456 214 ----------------------------------------------------------EDGHDVEAIAAAIEEAKAEKDK 235
                         330       340
                  ....*....|....*....|....*
gi 476961654  384 ATVILAHTIKGYGmGDAAEGKNIAH 408
Cdd:pfam00456 236 PTLIKCRTVIGYG-SPNKQGTHDVH 259
TktA COG0021
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...
225-408 4.44e-06

Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 439792 [Multi-domain]  Cd Length: 661  Bit Score: 50.39  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 225 VYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVTGngkIINE-LEGIFEGAGWNVIKVMWGsrwdell 303
Cdd:COG0021  149 TYVIAGDGDLMEGISHEAASLAGHLKLGKLIVLYDDNGISIDGDTDL---AFSEdVAKRFEAYGWHVIRVEDG------- 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 304 rkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrggHDPKKIYAAFKKAQETKGK 383
Cdd:COG0021  219 -------------------------------------------------------------HDLEAIDAAIEAAKAETDK 237
                        170       180
                 ....*....|....*....|....*
gi 476961654 384 ATVILAHTIKGYGMGDAAeGKNIAH 408
Cdd:COG0021  238 PTLIICKTIIGYGSPNKQ-GTAKAH 261
PTZ00089 PTZ00089
transketolase; Provisional
142-293 3.75e-05

transketolase; Provisional


Pssm-ID: 173383 [Multi-domain]  Cd Length: 661  Bit Score: 47.36  E-value: 3.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 142 GHISPGVYARAFLEGR-LTQEQLDNFRQEVhgnglSSYP-HPklmpEFWQFPTVSMGLGPIG-AIYQAKFLKYLEH---- 214
Cdd:PTZ00089  67 GHASALLYSMLHLTGYdLSMEDLKNFRQLG-----SRTPgHP----ERHITPGVEVTTGPLGqGIANAVGLAIAEKhlaa 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 215 ---RGLKDTSKQTVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVtgngkIINELEGI---FEGAGW 288
Cdd:PTZ00089 138 kfnRPGHPIFDNYVYVICGDGCLQEGVSQEALSLAGHLGLEKLIVLYDDNKITIDGNT-----DLSFTEDVekkYEAYGW 212

                 ....*
gi 476961654 289 NVIKV 293
Cdd:PTZ00089 213 HVIEV 217
TPP_enzymes cd00568
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
178-305 1.71e-04

Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.


Pssm-ID: 238318 [Multi-domain]  Cd Length: 168  Bit Score: 43.01  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 178 YPHPKLMPEFWQFPTVSMGLGPIGAIYQAKFLKylehrglkdtsKQTVYAFLGDGEMDepESKGAITIATREKLdNLVFV 257
Cdd:cd00568   31 LPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAP-----------DRPVVCIAGDGGFM--MTGQELATAVRYGL-PVIVV 96
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 476961654 258 INCN--------LQRLDGPVTGNGKIINE--LEGIFEGAGWNVIKVMWGSRWDELLRK 305
Cdd:cd00568   97 VFNNggygtirmHQEAFYGGRVSGTDLSNpdFAALAEAYGAKGVRVEDPEDLEAALAE 154
PLN02790 PLN02790
transketolase
142-749 6.01e-04

transketolase


Pssm-ID: 215424 [Multi-domain]  Cd Length: 654  Bit Score: 43.47  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 142 GHISPGVYARAFLEG--RLTQEQLDNFRQevHGnglSSYP-HPklmpEFWQFPTVSMGLGPIG-----AIYQAKFLKYLE 213
Cdd:PLN02790  55 GHGCMLQYALLHLAGydSVQMEDLKQFRQ--WG---SRTPgHP----ENFETPGIEVTTGPLGqgianAVGLALAEKHLA 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 214 HRGLKDTSK---QTVYAFLGDGEMDEPESKGAITIATREKLDNLVFVINCNLQRLDGPVTgngkiINELEGI---FEGAG 287
Cdd:PLN02790 126 ARFNKPDHKivdHYTYCILGDGCQMEGISNEAASLAGHWGLGKLIVLYDDNHISIDGDTE-----IAFTEDVdkrYEALG 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 288 WNVIkvmwgsrwdellrkdtsgkliqlmneTVDGdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrGGHDP 367
Cdd:PLN02790 201 WHTI--------------------------WVKN-----------------------------------------GNTDY 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 368 KKIYAAFKKAQETKGKATVILAHTIKGYGM----------GDAAEGKNIAHQVKKMNMDgvrhiRDRFNVP--VSD---- 431
Cdd:PLN02790 214 DEIRAAIKEAKAVTDKPTLIKVTTTIGYGSpnkansysvhGAALGEKEVDATRKNLGWP-----YEPFHVPedVKShwsk 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 432 -----ADIEKLPYITFPEGSEEHTYLHAQ-RQKLHGYLPSRQ----PNFTEKlelpslqdfgalleeqSKEISTTIAFVR 501
Cdd:PLN02790 289 htkegAALEAEWNAKFAEYKKKYPEEAAElKSLISGELPSGWekalPTFTPE----------------DPADATRNLSQK 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 502 ALNVMLKnksikdrLVP-II---ADEA---RTfgmegLFRQIGiyspNGQQYTPQDREqvayykedekgqiLQEGINE-- 572
Cdd:PLN02790 353 CLNALAK-------VLPgLIggsADLAssnMT-----LLKDFG----DFQKDTPEERN-------------VRFGVREhg 403
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 573 LGAGCSWLAAatsystNNLPMIP----FYIY--YsMFGFQRIGDLCWAagdqqargfligGTSGRTTLNGEGLQhEDGHS 646
Cdd:PLN02790 404 MGAICNGIAL------HSSGLIPycatFFVFtdY-MRAAMRLSALSEA------------GVIYVMTHDSIGLG-EDGPT 463
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 476961654 647 H--IQSL----TIPNCISYDPAYAYEVAVIMHDGLERMYGEkqenvyyyiTTLN-ENYHMPAMPEGAEEGIRKGIYKL-E 718
Cdd:PLN02790 464 HqpIEHLaslrAMPNILMLRPADGNETAGAYKVAVTNRKRP---------TVLAlSRQKVPNLPGTSIEGVEKGGYVIsD 534
                        650       660       670
                 ....*....|....*....|....*....|.
gi 476961654 719 TIEGSKGKVQLLGSGSILRHVREAAEILAKD 749
Cdd:PLN02790 535 NSSGNKPDLILIGTGSELEIAAKAAKELRKE 565
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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