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Conserved domains on  [gi|477324358|gb|ENF94198|]
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HNH endonuclease family protein [Escherichia coli P0305260.13]

Protein Classification

HNH endonuclease( domain architecture ID 10013777)

HNH endonuclease signature motif containing protein catalyzes the hydrolysis of DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11295 PRK11295
HNH nuclease family protein;
1-113 1.79e-85

HNH nuclease family protein;


:

Pssm-ID: 236895  Cd Length: 113  Bit Score: 243.82  E-value: 1.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 477324358   1 MAIIPKNYARLESGYREKALKIYPWVCGRCSREFVYSNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSKYTEAD 80
Cdd:PRK11295   1 MAIIPKNYARLESGYREKALKLYPWVCGRCSREFVYSNLRELTVHHIDHDHDNNPEDGSNWELLCLYCHDHEHSKYTEAD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 477324358  81 QYGTTVIAGEDAQKDVGEAKYNPFADLKAMMNK 113
Cdd:PRK11295  81 QYGSTVIAGEDAQKDVGEATYNPFADLKAMMKK 113
 
Name Accession Description Interval E-value
PRK11295 PRK11295
HNH nuclease family protein;
1-113 1.79e-85

HNH nuclease family protein;


Pssm-ID: 236895  Cd Length: 113  Bit Score: 243.82  E-value: 1.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 477324358   1 MAIIPKNYARLESGYREKALKIYPWVCGRCSREFVYSNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSKYTEAD 80
Cdd:PRK11295   1 MAIIPKNYARLESGYREKALKLYPWVCGRCSREFVYSNLRELTVHHIDHDHDNNPEDGSNWELLCLYCHDHEHSKYTEAD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 477324358  81 QYGTTVIAGEDAQKDVGEAKYNPFADLKAMMNK 113
Cdd:PRK11295  81 QYGSTVIAGEDAQKDVGEATYNPFADLKAMMKK 113
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 27-75 1.87e-11

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 54.67  E-value: 1.87e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 477324358   27 CGRCSREFVYSNlrELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSK 75
Cdd:pfam01844   1 CQYCGRPFHISD--ALTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
HNHc smart00507
HNH nucleases;
18-70 1.53e-05

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 39.36  E-value: 1.53e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 477324358    18 KALKIYPWVCGRCSREFVYsnlrELTVHHIDHDHTNNPEDGSNWELLCLYCHD 70
Cdd:smart00507   4 RLLLHRDGVCAYCGKPASE----GLEVDHIIPLSDGGNDDLDNLVLLCPKCHI 52
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 15-73 4.85e-05

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 38.22  E-value: 4.85e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 477324358  15 YREKALKIYPWvCGRCSREFVYSNLrelTVHHIDHDHTNNPEDGSNWELLCLYCHDHEH 73
Cdd:cd00085    3 HRLVLLARDGL-CPYCGKPGGTEGL---EVDHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
16-71 1.16e-03

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 34.57  E-value: 1.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 477324358  16 REKALKIYPWVCGRCSREFvysNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDH 71
Cdd:COG1403   11 RRAVLKRDNGRCQYCGRPF---SGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRR 63
 
Name Accession Description Interval E-value
PRK11295 PRK11295
HNH nuclease family protein;
1-113 1.79e-85

HNH nuclease family protein;


Pssm-ID: 236895  Cd Length: 113  Bit Score: 243.82  E-value: 1.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 477324358   1 MAIIPKNYARLESGYREKALKIYPWVCGRCSREFVYSNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSKYTEAD 80
Cdd:PRK11295   1 MAIIPKNYARLESGYREKALKLYPWVCGRCSREFVYSNLRELTVHHIDHDHDNNPEDGSNWELLCLYCHDHEHSKYTEAD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 477324358  81 QYGTTVIAGEDAQKDVGEAKYNPFADLKAMMNK 113
Cdd:PRK11295  81 QYGSTVIAGEDAQKDVGEATYNPFADLKAMMKK 113
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 27-75 1.87e-11

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 54.67  E-value: 1.87e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 477324358   27 CGRCSREFVYSNlrELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSK 75
Cdd:pfam01844   1 CQYCGRPFHISD--ALTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
HNHc smart00507
HNH nucleases;
18-70 1.53e-05

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 39.36  E-value: 1.53e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 477324358    18 KALKIYPWVCGRCSREFVYsnlrELTVHHIDHDHTNNPEDGSNWELLCLYCHD 70
Cdd:smart00507   4 RLLLHRDGVCAYCGKPASE----GLEVDHIIPLSDGGNDDLDNLVLLCPKCHI 52
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 15-73 4.85e-05

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 38.22  E-value: 4.85e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 477324358  15 YREKALKIYPWvCGRCSREFVYSNLrelTVHHIDHDHTNNPEDGSNWELLCLYCHDHEH 73
Cdd:cd00085    3 HRLVLLARDGL-CPYCGKPGGTEGL---EVDHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
16-71 1.16e-03

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 34.57  E-value: 1.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 477324358  16 REKALKIYPWVCGRCSREFvysNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDH 71
Cdd:COG1403   11 RRAVLKRDNGRCQYCGRPF---SGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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