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Conserved domains on  [gi|479375220|gb|ENP55448|]
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hypothetical protein C072_00057 [Brucella abortus 863/67]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11450351)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
18-152 7.91e-56

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 171.52  E-value: 7.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  18 PRALYAMLKLRVDVFVVEQT-CPYPEIDGKDICAFHLRILDGDTLAAALRVLPPeGEKSVKIGRVVVAPAYRGYKLGQRL 96
Cdd:COG2153    1 AEELYDALALRREVFVVEQGvPPYLELDGKDEDARHLLAYDDGELVATARLLPP-GDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 479375220  97 MTEAIAFAQARfPGSPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLEPS 152
Cdd:COG2153   80 MEAAIEEARER-GARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
18-152 7.91e-56

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 171.52  E-value: 7.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  18 PRALYAMLKLRVDVFVVEQT-CPYPEIDGKDICAFHLRILDGDTLAAALRVLPPeGEKSVKIGRVVVAPAYRGYKLGQRL 96
Cdd:COG2153    1 AEELYDALALRREVFVVEQGvPPYLELDGKDEDARHLLAYDDGELVATARLLPP-GDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 479375220  97 MTEAIAFAQARfPGSPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLEPS 152
Cdd:COG2153   80 MEAAIEEARER-GARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
PRK10314 PRK10314
GNAT family N-acetyltransferase;
9-150 9.90e-45

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 143.83  E-value: 9.90e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220   9 HWAEI--DDLAPRALYAMLKLRVDVFVVEQTCPYPEIDGKDICAFHLRIL--DGDTLAAALRVLPPEGE-KSVKIGRVVV 83
Cdd:PRK10314   3 EWQDLhhSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILgwKNDELVAYARILKSDDDlEPVVIGRVIV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 479375220  84 APAYRGYKLGQRLMTEAIAFAQARFPGSPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLE 150
Cdd:PRK10314  83 SEALRGEKVGQQLMSKTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMARE 149
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 77-150 5.39e-15

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 66.91  E-value: 5.39e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 479375220   77 KIGRVVVAPAYRGYKLGQRLMTEAIAFAQARFPG-SPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLE 150
Cdd:pfam13673  53 HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKlSELTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEKE 127
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 55-107 2.22e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 2.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 479375220  55 ILDGDTLAAALRVLP-PEGEKSVKIGRVVVAPAYRGYKLGQRLMTEAIAFAQAR 107
Cdd:cd04301    4 AEDDGEIVGFASLSPdGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARER 57
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
18-152 7.91e-56

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 171.52  E-value: 7.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  18 PRALYAMLKLRVDVFVVEQT-CPYPEIDGKDICAFHLRILDGDTLAAALRVLPPeGEKSVKIGRVVVAPAYRGYKLGQRL 96
Cdd:COG2153    1 AEELYDALALRREVFVVEQGvPPYLELDGKDEDARHLLAYDDGELVATARLLPP-GDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 479375220  97 MTEAIAFAQARfPGSPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLEPS 152
Cdd:COG2153   80 MEAAIEEARER-GARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
PRK10314 PRK10314
GNAT family N-acetyltransferase;
9-150 9.90e-45

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 143.83  E-value: 9.90e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220   9 HWAEI--DDLAPRALYAMLKLRVDVFVVEQTCPYPEIDGKDICAFHLRIL--DGDTLAAALRVLPPEGE-KSVKIGRVVV 83
Cdd:PRK10314   3 EWQDLhhSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILgwKNDELVAYARILKSDDDlEPVVIGRVIV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 479375220  84 APAYRGYKLGQRLMTEAIAFAQARFPGSPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLE 150
Cdd:PRK10314  83 SEALRGEKVGQQLMSKTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMARE 149
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 77-150 5.39e-15

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 66.91  E-value: 5.39e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 479375220   77 KIGRVVVAPAYRGYKLGQRLMTEAIAFAQARFPG-SPLELGGQSHLQKFYASFGFVAISGEYLEDGIPHVDMRLE 150
Cdd:pfam13673  53 HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKlSELTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEKE 127
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
57-150 5.58e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 57.02  E-value: 5.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  57 DGDTLAAALRVLPPEGEKSVK---IGRVVVAPAYRGYKLGQRLMTEAIAFAQARfpGSP-LELGGQSHLQKFYASFGFVA 132
Cdd:COG3153   46 DDGEIVGHVALSPVDIDGEGPallLGPLAVDPEYRGQGIGRALMRAALEAARER--GARaVVLLGDPSLLPFYERFGFRP 123

                         90
                 ....*....|....*...
gi 479375220 133 ISGEYLEDGIPHVDMRLE 150
Cdd:COG3153  124 AGELGLTLGPDEVFLAKE 141
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 11-138 4.28e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 51.53  E-value: 4.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  11 AEIDDLAP----RALYAMLKLRVDVFVVEQtcpypeiDGKdICAFhlrildgdtlaAALRVLPpegEKSVKIGRVVVAPA 86
Cdd:COG1246    6 ATPDDVPAilelIRPYALEEEIGEFWVAEE-------DGE-IVGC-----------AALHPLD---EDLAELRSLAVHPD 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 479375220  87 YRGYKLGQRLMTEAIAFAQARfpG-SPLELGGQSHLQKFYASFGFVAISGEYL 138
Cdd:COG1246   64 YRGRGIGRRLLEALLAEAREL--GlKRLFLLTTSAAIHFYEKLGFEEIDKEDL 114
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 55-131 9.87e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.76  E-value: 9.87e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 479375220   55 ILDGDTLAAALRVLPPEGEKSVKIGRVVVAPAYRGYKLGQRLMTEAIAFAQARFPGSpLELGGQSHLQKFYASFGFV 131
Cdd:pfam13508   8 AEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKL-LELETTNRAAAFYEKLGFE 83
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 69-150 5.31e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 45.03  E-value: 5.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  69 PPEGEKSVKIGRVVVAPAYRGYKLGQRLMTEAIAFAQARfPGSPLELGGQSH---LQKFYASFGFVAISGEYLEDGIPHV 145
Cdd:COG0456    7 LVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDneaAIALYEKLGFEEVGERPNYYGDDAL 85


                 ....*
gi 479375220 146 DMRLE 150
Cdd:COG0456   86 VMEKE 90
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 4-152 7.20e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 45.81  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220   4 SLLTSHWAEIDDLAPR-ALYAMLKLRVDVFVvEQTCPYPEIDGKDICAFHLRILDGDTLaaalrvlppegeksvKIGRVV 82
Cdd:COG0454    2 SIRKATPEDINFILLIeALDAELKAMEGSLA-GAEFIAVDDKGEPIGFAGLRRLDDKVL---------------ELKRLY 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479375220  83 VAPAYRGYKLGQRLMTEAIAFAQARFPGS-PLELG-GQSHLQKFYASFGFVAIsGEYLEDGIPHVDMRLEPS 152
Cdd:COG0454   66 VLPEYRGKGIGKALLEALLEWARERGCTAlELDTLdGNPAAIRFYERLGFKEI-ERYVAYVGGEFEKELSLS 136
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 21-130 3.16e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 43.66  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220   21 LYAMLKLRVDVF-VVEQTCPYPEIDGKDICAFHLRIL--DGDTLAAALRVLP-PEGEKSVKIGRVVVAPAYRGYKLGQRL 96
Cdd:pfam00583   1 LEALYELLSEEFpEPWPDEPLDLLEDWDEDASEGFFVaeEDGELVGFASLSIiDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 479375220   97 MTEAIAFAQARfPGSPLELGGQSH---LQKFYASFGF 130
Cdd:pfam00583  81 LQALLEWARER-GCERIFLEVAADnlaAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 55-107 2.22e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 2.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 479375220  55 ILDGDTLAAALRVLP-PEGEKSVKIGRVVVAPAYRGYKLGQRLMTEAIAFAQAR 107
Cdd:cd04301    4 AEDDGEIVGFASLSPdGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARER 57
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
47-147 5.37e-05

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 41.07  E-value: 5.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  47 DICAFHLRILDGDTLAAALRVLPPEG--------------EKSVKIGRVVVAPAYRGYKLGQRLMTEAIAFAQARF---- 108
Cdd:COG3818   42 EQAAYARVAEVDGEVAGFLLAFGPGAdydspnyrwfaeryDNFLYIDRIVVAPSARGRGLGRALYADVFSYARARGvprv 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 479375220 109 ----------PGSplelggqshlQKFYASFGFVAISGEYLEDGIPHVDM 147
Cdd:COG3818  122 tcevnleppnPGS----------LAFHARLGFREVGQQRVAGGKKRVSL 160
Eis COG4552
Predicted acetyltransferase [General function prediction only];
52-130 6.07e-04

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 38.73  E-value: 6.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479375220  52 HLRILDGDTLAAALRVLPPE---GEKSVK---IGRVVVAPAYRGYKLGQRLMTEAIAFAQARfpGSPLelggqSHL---- 121
Cdd:COG4552   43 VLGVFDDGELVGTLALYPFTlnvGGARVPmagITGVAVAPEHRRRGVARALLREALAELRER--GQPL-----SALypfe 115


                 ....*....
gi 479375220 122 QKFYASFGF 130
Cdd:COG4552  116 PGFYRRFGY 124
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
78-137 1.65e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 35.65  E-value: 1.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479375220  78 IGRVVVAPAYRGYKLGQRLMTEAIAFAQARFPGSP-LELGGQSH-LQKFYASFGFVAIsGEY 137
Cdd:COG3393   18 ISGVYTHPEYRGRGLASALVAALAREALARGARTPfLYVDADNPaARRLYERLGFRPV-GEY 78
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
65-107 4.18e-03

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 36.06  E-value: 4.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 479375220  65 LRVLppeGEKSVKIGRVVVAPAYRGYKLGQRLMTEAIAFAQAR 107
Cdd:PRK10975 119 LREL---NDTDARIGLLAVFPGAQGRGIGARLMQAALNWCQAR 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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