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Conserved domains on  [gi|479755377|gb|ENT25242|]
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TonB family domain-containing protein [Brucella suis 01-5744]

Protein Classification

tonB_Cterm family protein( domain architecture ID 13469481)

tonB_Cterm family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 237-308 2.58e-10

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 55.77  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479755377  237 QGKSRNTRGEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARRaSPVPAPPAAIAKVRMPITMPLLFK 308
Cdd:TIGR01352   2 RARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRK-ARFEPPPPPGGVVAASVTIPVRFK 72
PRK10819 super family cl35954
transport protein TonB; Provisional
 109-264 1.24e-07

transport protein TonB; Provisional


The actual alignment was detected with superfamily member PRK10819:

Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 51.61  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479755377 109 AKAEPQQVQEPE---EVIPDvveaqkPEVAVPLPVEKPQEKPEEKPKAEPKPEPKKVEKLKPQKPKPEKVKPKKAEKAAE 185
Cdd:PRK10819  64 VQPPPEPVVEPEpepEPIPE------PPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKREVKPVEPRPASPFENTAP 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 479755377 186 TREASAPrvdadngaKVAASKRGETSASAGviwAKWTSRLQSHMARNARFLQgksrnTRGEAHVAFVIDPSGNVLSARI 264
Cdd:PRK10819 138 ARPTSST--------ATAAASKPVTSVSSG---PRALSRNQPQYPARAQALR-----IEGQVKVKFDVDEDGRVDNVRI 200
 
Name Accession Description Interval E-value
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 237-308 2.58e-10

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 55.77  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479755377  237 QGKSRNTRGEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARRaSPVPAPPAAIAKVRMPITMPLLFK 308
Cdd:TIGR01352   2 RARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRK-ARFEPPPPPGGVVAASVTIPVRFK 72
PRK10819 PRK10819
transport protein TonB; Provisional
 109-264 1.24e-07

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 51.61  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479755377 109 AKAEPQQVQEPE---EVIPDvveaqkPEVAVPLPVEKPQEKPEEKPKAEPKPEPKKVEKLKPQKPKPEKVKPKKAEKAAE 185
Cdd:PRK10819  64 VQPPPEPVVEPEpepEPIPE------PPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKREVKPVEPRPASPFENTAP 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 479755377 186 TREASAPrvdadngaKVAASKRGETSASAGviwAKWTSRLQSHMARNARFLQgksrnTRGEAHVAFVIDPSGNVLSARI 264
Cdd:PRK10819 138 ARPTSST--------ATAAASKPVTSVSSG---PRALSRNQPQYPARAQALR-----IEGQVKVKFDVDEDGRVDNVRI 200
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 239-283 7.12e-07

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 46.04  E-value: 7.12e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 479755377 239 KSRNTRGEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARR 283
Cdd:COG0810    5 RRRGIEGTVTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRR 49
TonB_2 pfam13103
TonB C terminal; This family contains TonB members that are not captured by pfam03544.
 219-283 8.94e-05

TonB C terminal; This family contains TonB members that are not captured by pfam03544.


Pssm-ID: 463788 [Multi-domain]  Cd Length: 85  Bit Score: 40.39  E-value: 8.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 479755377  219 AKWTSRLQSHMARNARFLQGKSRNTrgEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARR 283
Cdd:pfam13103   2 DEYAAKVRAIIRENWAPPSGISGNL--EAVVEITIDPDGTIVSVRLVKSSGNEAFDKAVLRALEK 64
 
Name Accession Description Interval E-value
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 237-308 2.58e-10

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 55.77  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479755377  237 QGKSRNTRGEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARRaSPVPAPPAAIAKVRMPITMPLLFK 308
Cdd:TIGR01352   2 RARRRGIEGTVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRK-ARFEPPPPPGGVVAASVTIPVRFK 72
PRK10819 PRK10819
transport protein TonB; Provisional
 109-264 1.24e-07

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 51.61  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479755377 109 AKAEPQQVQEPE---EVIPDvveaqkPEVAVPLPVEKPQEKPEEKPKAEPKPEPKKVEKLKPQKPKPEKVKPKKAEKAAE 185
Cdd:PRK10819  64 VQPPPEPVVEPEpepEPIPE------PPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKREVKPVEPRPASPFENTAP 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 479755377 186 TREASAPrvdadngaKVAASKRGETSASAGviwAKWTSRLQSHMARNARFLQgksrnTRGEAHVAFVIDPSGNVLSARI 264
Cdd:PRK10819 138 ARPTSST--------ATAAASKPVTSVSSG---PRALSRNQPQYPARAQALR-----IEGQVKVKFDVDEDGRVDNVRI 200
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 239-283 7.12e-07

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 46.04  E-value: 7.12e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 479755377 239 KSRNTRGEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARR 283
Cdd:COG0810    5 RRRGIEGTVTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRR 49
TonB_2 pfam13103
TonB C terminal; This family contains TonB members that are not captured by pfam03544.
 219-283 8.94e-05

TonB C terminal; This family contains TonB members that are not captured by pfam03544.


Pssm-ID: 463788 [Multi-domain]  Cd Length: 85  Bit Score: 40.39  E-value: 8.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 479755377  219 AKWTSRLQSHMARNARFLQGKSRNTrgEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARR 283
Cdd:pfam13103   2 DEYAAKVRAIIRENWAPPSGISGNL--EAVVEITIDPDGTIVSVRLVKSSGNEAFDKAVLRALEK 64
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 239-283 1.01e-04

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 39.96  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 479755377  239 KSRNTRGEAHVAFVIDPSGNVLSARIAVSSGDPAVDQLALEAARR 283
Cdd:pfam03544  10 RRRGIEGTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKK 54
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
74-163 9.95e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 40.80  E-value: 9.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479755377  74 VAPAEERVSEEVQPEttteqpEEVQPEPEPEPQPEAKAEPQQVQEPEEVI--PDVVEAQKPEVAVPLPVEKPQEKPEEKP 151
Cdd:PRK14960 361 LAPNEILVSEPVQQN------GQAEVGLNSQAQTAQEITPVSAVQPVEVIsqPAMVEPEPEPEPEPEPEPEPEPEPEPEP 434

                         90
                 ....*....|..
gi 479755377 152 KAEPKPEPKKVE 163
Cdd:PRK14960 435 EPEPEPEPQPNQ 446
rne PRK10811
ribonuclease E; Reviewed
 51-205 2.25e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 39.64  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479755377   51 AQEDNQPEGTEVAAMVVELVPDLVAPAEERVSEEVQPETTTEQPEEVQpepepepqpeakAEPQQVQEPEEVIPDVVEAQ 130
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVV------------EEPVVVAEPQPEEVVVVETT 915

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 479755377  131 KPEVAVPLPVEKPQEKPEEkpkAEPKPEPKKVEKLKPQKPKPEKVKPKKAEKAAETREASAPRVDADNGAKVAAS 205
Cdd:PRK10811  916 HPEVIAAPVTEQPQVITES---DVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEV 987
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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