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Conserved domains on  [gi|479812247|gb|ENT81052|]
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formate dehydrogenase family accessory protein FdhD [Brucella ovis IntaBari-2010-47-268]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FdhD-NarQ super family cl00659
FdhD/NarQ family; A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, and ...
 1-45 7.48e-17

FdhD/NarQ family; A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, and FdhD are required for formate dehydrogenase activity. Structurally, they possess a deaminase fold with a characteriztic binding pocket, suggesting that they might bind a nucleotide or related molecule allosterically to regulate the formate dehydrogenase catalytic subunit.


The actual alignment was detected with superfamily member PRK00724:

Pssm-ID: 469863  Cd Length: 263  Bit Score: 70.21  E-value: 7.48e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 479812247   1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGR 45
Cdd:PRK00724 219 MAGIPILVAVSAPTSLAVELAEELGLTLVGFARGGRFNIYTHPQR 263
 
Name Accession Description Interval E-value
PRK00724 PRK00724
formate dehydrogenase accessory sulfurtransferase FdhD;
1-45 7.48e-17

formate dehydrogenase accessory sulfurtransferase FdhD;


Pssm-ID: 234823  Cd Length: 263  Bit Score: 70.21  E-value: 7.48e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 479812247   1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGR 45
Cdd:PRK00724 219 MAGIPILVAVSAPTSLAVELAEELGLTLVGFARGGRFNIYTHPQR 263
FdhD-NarQ pfam02634
FdhD/NarQ family; A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, and ...
 1-47 9.02e-16

FdhD/NarQ family; A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, and FdhD are required for formate dehydrogenase activity. Structurally, they possess a deaminase fold with a characteriztic binding pocket, suggesting that they might bind a nucleotide or related molecule allosterically to regulate the formate dehydrogenase catalytic subunit.


Pssm-ID: 460633  Cd Length: 238  Bit Score: 67.19  E-value: 9.02e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 479812247    1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGRII 47
Cdd:pfam02634 192 RAGIPVLVSRSAPTSLAVELAEELGITLIGFARGGRFNVYTHPERII 238
FdhD COG1526
Formate dehydrogenase assembly factor FdhD, a sulfurtransferase [Energy production and ...
 1-46 2.75e-15

Formate dehydrogenase assembly factor FdhD, a sulfurtransferase [Energy production and conversion];


Pssm-ID: 441135  Cd Length: 260  Bit Score: 65.95  E-value: 2.75e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 479812247   1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGRI 46
Cdd:COG1526  215 RAGIPILVSVSAPTSLAVELAEEAGLTLIGFARGDRFNVYTHPERI 260
fdhD_narQ TIGR00129
formate dehydrogenase family accessory protein FdhD; FdhD in E. coli and NarQ in B. subtilis ...
 1-48 6.94e-10

formate dehydrogenase family accessory protein FdhD; FdhD in E. coli and NarQ in B. subtilis are required for the activity of formate dehydrogenase. The gene name in B. subtilis reflects the requirement of the neighboring gene narA for nitrate assimilation, for which NarQ is not required. In some species, the gene is associated not with a known formate dehydrogenase but with a related putative molybdopterin-binding oxidoreductase. A reasonable hypothesis is that this protein helps prepare a required cofactor for assembly into the holoenzyme. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 272923  Cd Length: 237  Bit Score: 51.32  E-value: 6.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 479812247    1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGRIIE 48
Cdd:TIGR00129 190 RCGVPIIASKSAPTDLAIEVAEESNITLIGFARNGRFNIYTHPERLLE 237
 
Name Accession Description Interval E-value
PRK00724 PRK00724
formate dehydrogenase accessory sulfurtransferase FdhD;
1-45 7.48e-17

formate dehydrogenase accessory sulfurtransferase FdhD;


Pssm-ID: 234823  Cd Length: 263  Bit Score: 70.21  E-value: 7.48e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 479812247   1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGR 45
Cdd:PRK00724 219 MAGIPILVAVSAPTSLAVELAEELGLTLVGFARGGRFNIYTHPQR 263
FdhD-NarQ pfam02634
FdhD/NarQ family; A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, and ...
 1-47 9.02e-16

FdhD/NarQ family; A pan-bacterial lineage of proteins. Nitrate assimilation protein, NarQ, and FdhD are required for formate dehydrogenase activity. Structurally, they possess a deaminase fold with a characteriztic binding pocket, suggesting that they might bind a nucleotide or related molecule allosterically to regulate the formate dehydrogenase catalytic subunit.


Pssm-ID: 460633  Cd Length: 238  Bit Score: 67.19  E-value: 9.02e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 479812247    1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGRII 47
Cdd:pfam02634 192 RAGIPVLVSRSAPTSLAVELAEELGITLIGFARGGRFNVYTHPERII 238
FdhD COG1526
Formate dehydrogenase assembly factor FdhD, a sulfurtransferase [Energy production and ...
 1-46 2.75e-15

Formate dehydrogenase assembly factor FdhD, a sulfurtransferase [Energy production and conversion];


Pssm-ID: 441135  Cd Length: 260  Bit Score: 65.95  E-value: 2.75e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 479812247   1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGRI 46
Cdd:COG1526  215 RAGIPILVSVSAPTSLAVELAEEAGLTLIGFARGDRFNVYTHPERI 260
fdhD_narQ TIGR00129
formate dehydrogenase family accessory protein FdhD; FdhD in E. coli and NarQ in B. subtilis ...
 1-48 6.94e-10

formate dehydrogenase family accessory protein FdhD; FdhD in E. coli and NarQ in B. subtilis are required for the activity of formate dehydrogenase. The gene name in B. subtilis reflects the requirement of the neighboring gene narA for nitrate assimilation, for which NarQ is not required. In some species, the gene is associated not with a known formate dehydrogenase but with a related putative molybdopterin-binding oxidoreductase. A reasonable hypothesis is that this protein helps prepare a required cofactor for assembly into the holoenzyme. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 272923  Cd Length: 237  Bit Score: 51.32  E-value: 6.94e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 479812247    1 MLGVLVLAAISAPTALAIRTAEAANLTLVALVRDEEFDIYTHCGRIIE 48
Cdd:TIGR00129 190 RCGVPIIASKSAPTDLAIEVAEESNITLIGFARNGRFNIYTHPERLLE 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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