NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|479812260|gb|ENT81065|]
View 

alkyl hydroperoxide reductase AhpD [Brucella ovis IntaBari-2010-47-268]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ahpD super family cl39101
alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which ...
 2-124 1.11e-42

alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification]


The actual alignment was detected with superfamily member TIGR00777:

Pssm-ID: 129859 [Multi-domain]  Cd Length: 177  Bit Score: 138.56  E-value: 1.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479812260    2 PMCARHLLPKLPGKVDASVIQAAKAAASIMGMNNVYYRFVHLASNKDYRTMPARLRMNVISNPGVDKVDFELWSLAVSAI 81
Cdd:TIGR00777  48 PQVLRDIGAEATAHLSAEARHAALGAAAIMAMNNVFYRGRHLLEGARYDDLRPGLRMNIIANPGIPKVNFELWSFAVSAI 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 479812260   82 NGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEA 124
Cdd:TIGR00777 128 NGCGHCLDSHEHTLRTVGVDREAIQEALKIAAVVSAVAQTLAA 170
 
Name Accession Description Interval E-value
ahpD TIGR00777
alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which ...
 2-124 1.11e-42

alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification]


Pssm-ID: 129859 [Multi-domain]  Cd Length: 177  Bit Score: 138.56  E-value: 1.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479812260    2 PMCARHLLPKLPGKVDASVIQAAKAAASIMGMNNVYYRFVHLASNKDYRTMPARLRMNVISNPGVDKVDFELWSLAVSAI 81
Cdd:TIGR00777  48 PQVLRDIGAEATAHLSAEARHAALGAAAIMAMNNVFYRGRHLLEGARYDDLRPGLRMNIIANPGIPKVNFELWSFAVSAI 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 479812260   82 NGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEA 124
Cdd:TIGR00777 128 NGCGHCLDSHEHTLRTVGVDREAIQEALKIAAVVSAVAQTLAA 170
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 48-125 3.93e-11

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 55.01  E-value: 3.93e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 479812260   48 DYRTMPARLRMNVISNPGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEAA 125
Cdd:pfam02627   2 ELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 60-110 1.55e-06

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 44.10  E-value: 1.55e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 479812260  60 VISNPGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVR 110
Cdd:COG2128   16 LMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRA 66
 
Name Accession Description Interval E-value
ahpD TIGR00777
alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which ...
 2-124 1.11e-42

alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification]


Pssm-ID: 129859 [Multi-domain]  Cd Length: 177  Bit Score: 138.56  E-value: 1.11e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479812260    2 PMCARHLLPKLPGKVDASVIQAAKAAASIMGMNNVYYRFVHLASNKDYRTMPARLRMNVISNPGVDKVDFELWSLAVSAI 81
Cdd:TIGR00777  48 PQVLRDIGAEATAHLSAEARHAALGAAAIMAMNNVFYRGRHLLEGARYDDLRPGLRMNIIANPGIPKVNFELWSFAVSAI 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 479812260   82 NGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEA 124
Cdd:TIGR00777 128 NGCGHCLDSHEHTLRTVGVDREAIQEALKIAAVVSAVAQTLAA 170
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 64-112 2.07e-13

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 60.08  E-value: 2.07e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 479812260   64 PGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVRFA 112
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWA 49
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 48-125 3.93e-11

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 55.01  E-value: 3.93e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 479812260   48 DYRTMPARLRMNVISNPGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEAA 125
Cdd:pfam02627   2 ELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAAL 79
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 60-110 1.55e-06

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 44.10  E-value: 1.55e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 479812260  60 VISNPGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVR 110
Cdd:COG2128   16 LMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRA 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH