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Conserved domains on  [gi|479816257|gb|ENT84964|]
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glucose-6-phosphate isomerase [Brucella ovis IntaBari-2010-47-268]

Protein Classification

glucose-6-phosphate isomerase( domain architecture ID 11478291)

glucose-6-phosphate isomerase (GPI) catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
pgi PRK00179
glucose-6-phosphate isomerase; Reviewed
10-548 0e+00

glucose-6-phosphate isomerase; Reviewed


:

Pssm-ID: 234679  Cd Length: 548  Bit Score: 1009.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  10 ATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINN 89
Cdd:PRK00179   9 PAWQALQAHADEIKDVHLRDLFAADPDRFERFSLTAGGLLLDYSKNRITDETLALLLDLAREAGLEGARDAMFAGEKINT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  90 TEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALA 169
Cdd:PRK00179  89 TEDRAVLHTALRNPSNTPILVDGQDVMPEVHAVLARMKAFAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 170 PYHDGP-RAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAVSTALDK 247
Cdd:PRK00179 169 PYADPGlRVHFVSNVDGAHLAETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLAAGGdEAAVAKHFVAVSTNAEA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 248 VAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICG 327
Cdd:PRK00179 249 VAEFGIDPDNMFGFWDWVGGRYSLWSAIGLSIALAIGPDNFEELLAGAHAMDEHFRTAPLEKNLPVLLALIGVWYRNFFG 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 328 YGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKG 407
Cdd:PRK00179 329 AQSHAVLPYDQYLHRFPAYLQQLEMESNGKSVDRDGTPVDYQTGPIIWGEPGTNGQHAFFQLLHQGTKLVPADFIAPAQP 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 408 HEPtLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIAL 487
Cdd:PRK00179 409 HNP-LGDHHDLLLANCFAQTEALMFGKTAEEVRAELRAKGLDEAEAEELAPHKVFPGNRPSTTILLDRLTPFTLGALIAL 487
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 479816257 488 YEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRK 548
Cdd:PRK00179 488 YEHKVFVQGVIWGINSFDQWGVELGKQLAKRILPELEGDSEASAHDSSTNGLINRYRAWRG 548
 
Name Accession Description Interval E-value
pgi PRK00179
glucose-6-phosphate isomerase; Reviewed
10-548 0e+00

glucose-6-phosphate isomerase; Reviewed


Pssm-ID: 234679  Cd Length: 548  Bit Score: 1009.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  10 ATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINN 89
Cdd:PRK00179   9 PAWQALQAHADEIKDVHLRDLFAADPDRFERFSLTAGGLLLDYSKNRITDETLALLLDLAREAGLEGARDAMFAGEKINT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  90 TEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALA 169
Cdd:PRK00179  89 TEDRAVLHTALRNPSNTPILVDGQDVMPEVHAVLARMKAFAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 170 PYHDGP-RAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAVSTALDK 247
Cdd:PRK00179 169 PYADPGlRVHFVSNVDGAHLAETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLAAGGdEAAVAKHFVAVSTNAEA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 248 VAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICG 327
Cdd:PRK00179 249 VAEFGIDPDNMFGFWDWVGGRYSLWSAIGLSIALAIGPDNFEELLAGAHAMDEHFRTAPLEKNLPVLLALIGVWYRNFFG 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 328 YGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKG 407
Cdd:PRK00179 329 AQSHAVLPYDQYLHRFPAYLQQLEMESNGKSVDRDGTPVDYQTGPIIWGEPGTNGQHAFFQLLHQGTKLVPADFIAPAQP 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 408 HEPtLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIAL 487
Cdd:PRK00179 409 HNP-LGDHHDLLLANCFAQTEALMFGKTAEEVRAELRAKGLDEAEAEELAPHKVFPGNRPSTTILLDRLTPFTLGALIAL 487
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 479816257 488 YEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRK 548
Cdd:PRK00179 488 YEHKVFVQGVIWGINSFDQWGVELGKQLAKRILPELEGDSEASAHDSSTNGLINRYRAWRG 548
Pgi COG0166
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ...
37-545 0e+00

Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439936  Cd Length: 484  Bit Score: 731.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  37 RFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADvegRRAAMFAGEHINNTEDRAVLHVALRDtsskevLVDGHNVL 116
Cdd:COG0166   12 RFERFSLEAAGLLLDYSKNRITDETLELLLELAEEEE---AREALFAGEKINPTEGRAVLHGALRL------PEAGEDVM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 117 PDVKHVLDRMAAFADGIRsgalkgaTGRKITDIVNIGIGGSDLGPVMATLALAPY-HDGPRAHFVSNIDGAHIADTLSPL 195
Cdd:COG0166   83 PEVREELARIKAFAEKVR-------TGKRITDVVNIGIGGSDLGPRAVIEALKPYfRDGPRVHFVSNVDPDYLAELLAGL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 196 DPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAaVGAHFAAVSTALDKVAAFGIPED-RVFGFWDWVGGRYSVWSA 274
Cdd:COG0166  156 DPETTLFIVISKSGTTQETLTNARVAREWLEKAGGED-AAKHFVAVTDNAGALRAFGIDEGyNTFPFPDWVGGRYSVLSA 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 275 IGLPVMIAVGPDnFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMES 354
Cdd:COG0166  235 VGLLPAAAIGID-FEELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYRNFKGAETEAVLPYDQRLERFPAWLQQLWMES 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 355 NGKSVTLDGKPVSGPTGPVvwGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTldhqHEMLMANClaQSEALMKGR 434
Cdd:COG0166  314 NGKSVDRDGNPVGYGTGPV--GEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDI----PDLLLANL--QGLALLAGK 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 435 TLDEARAQLQAKnlpasqveriAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKE 514
Cdd:COG0166  386 TLDEVLALAAEA----------TPHALFPGNRPSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKK 455
                        490       500       510
                 ....*....|....*....|....*....|.
gi 479816257 515 LATELLPVVSGKEGASGrdASTQGLVAHLHA 545
Cdd:COG0166  456 LAFALLGKLGGEEAAAG--DSTEALLKRLRA 484
PGI pfam00342
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ...
51-540 0e+00

Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.


Pssm-ID: 395271  Cd Length: 487  Bit Score: 695.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257   51 DWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFA 130
Cdd:pfam00342   1 DYSKNHINDEILTALVKLAEERGVDAAREAMFNGEKINSTENRAVLHVALRNRSNTPIYVDGKDVMPEVNAVLAKMKSFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  131 DGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHD-GPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTF 209
Cdd:pfam00342  81 ERVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALKPYSGrDLDVHFVSNVDGTHIAEVLKKLNPETTLFIVASKTF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  210 TTIETMTNAQTARKWVADTLGE-AAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNF 288
Cdd:pfam00342 161 TTAETMTNAESAKEWLLKALKDdSAVAKHFIALSTNAEKVEEFGIDTKNMFEFWDWVGGRYSLWSAIGLPIALSIGFENF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  289 RKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSG 368
Cdd:pfam00342 241 QQLLEGAHAMDKHFLSAPPEKNIPVLLALLGVWYNNFFGAQTHAILPYDQYLHRFPAYLQQLDMESNGKYVTRDGVLVDH 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  369 PTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQaknl 448
Cdd:pfam00342 321 QTGPIIFGEPGTNGQHAFYQLIHQGTRLIPCDFIGAVQSQNPENGDHHKILLSNFFAQTEALMVGKSPEEVRKELA---- 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  449 pASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEG 528
Cdd:pfam00342 397 -AADVEHLIPHKTFTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVELGKVLAKSILPELENSNK 475
                         490
                  ....*....|..
gi 479816257  529 ASGRDASTQGLV 540
Cdd:pfam00342 476 VSSHDSSTNGLI 487
SIS_PGI_2 cd05016
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ...
330-519 2.13e-78

Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.


Pssm-ID: 240147  Cd Length: 164  Bit Score: 243.66  E-value: 2.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 330 SRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVsgPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHE 409
Cdd:cd05016    2 THALLPYSQRLERFPAWLQQLDMESNGKSVTRDGEDY--PTGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVKKPQN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 410 PTLD-----HQHEMLMANCLAQSEALMkgrtldearaqlqaknlpasqveriaphrvFSGNRPSLTLIHDMLDPYALGRL 484
Cdd:cd05016   80 DVLDylagkTLHDLLLANCLATREALM------------------------------FPGGRPSNTIVLPELTPYTLGAL 129
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 479816257 485 IALYEHRVFVEAQIFGINAFDQWGVELGKELATEL 519
Cdd:cd05016  130 LALYEHKTAVQGALLGINPFDQPGVELGKKLAKKI 164
 
Name Accession Description Interval E-value
pgi PRK00179
glucose-6-phosphate isomerase; Reviewed
10-548 0e+00

glucose-6-phosphate isomerase; Reviewed


Pssm-ID: 234679  Cd Length: 548  Bit Score: 1009.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  10 ATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINN 89
Cdd:PRK00179   9 PAWQALQAHADEIKDVHLRDLFAADPDRFERFSLTAGGLLLDYSKNRITDETLALLLDLAREAGLEGARDAMFAGEKINT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  90 TEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALA 169
Cdd:PRK00179  89 TEDRAVLHTALRNPSNTPILVDGQDVMPEVHAVLARMKAFAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 170 PYHDGP-RAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAVSTALDK 247
Cdd:PRK00179 169 PYADPGlRVHFVSNVDGAHLAETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLAAGGdEAAVAKHFVAVSTNAEA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 248 VAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICG 327
Cdd:PRK00179 249 VAEFGIDPDNMFGFWDWVGGRYSLWSAIGLSIALAIGPDNFEELLAGAHAMDEHFRTAPLEKNLPVLLALIGVWYRNFFG 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 328 YGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKG 407
Cdd:PRK00179 329 AQSHAVLPYDQYLHRFPAYLQQLEMESNGKSVDRDGTPVDYQTGPIIWGEPGTNGQHAFFQLLHQGTKLVPADFIAPAQP 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 408 HEPtLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIAL 487
Cdd:PRK00179 409 HNP-LGDHHDLLLANCFAQTEALMFGKTAEEVRAELRAKGLDEAEAEELAPHKVFPGNRPSTTILLDRLTPFTLGALIAL 487
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 479816257 488 YEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRK 548
Cdd:PRK00179 488 YEHKVFVQGVIWGINSFDQWGVELGKQLAKRILPELEGDSEASAHDSSTNGLINRYRAWRG 548
Pgi COG0166
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ...
37-545 0e+00

Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439936  Cd Length: 484  Bit Score: 731.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  37 RFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADvegRRAAMFAGEHINNTEDRAVLHVALRDtsskevLVDGHNVL 116
Cdd:COG0166   12 RFERFSLEAAGLLLDYSKNRITDETLELLLELAEEEE---AREALFAGEKINPTEGRAVLHGALRL------PEAGEDVM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 117 PDVKHVLDRMAAFADGIRsgalkgaTGRKITDIVNIGIGGSDLGPVMATLALAPY-HDGPRAHFVSNIDGAHIADTLSPL 195
Cdd:COG0166   83 PEVREELARIKAFAEKVR-------TGKRITDVVNIGIGGSDLGPRAVIEALKPYfRDGPRVHFVSNVDPDYLAELLAGL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 196 DPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAaVGAHFAAVSTALDKVAAFGIPED-RVFGFWDWVGGRYSVWSA 274
Cdd:COG0166  156 DPETTLFIVISKSGTTQETLTNARVAREWLEKAGGED-AAKHFVAVTDNAGALRAFGIDEGyNTFPFPDWVGGRYSVLSA 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 275 IGLPVMIAVGPDnFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMES 354
Cdd:COG0166  235 VGLLPAAAIGID-FEELLAGAHAMDEHFRTAPLEENPPVLLALLGIWYRNFKGAETEAVLPYDQRLERFPAWLQQLWMES 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 355 NGKSVTLDGKPVSGPTGPVvwGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTldhqHEMLMANClaQSEALMKGR 434
Cdd:COG0166  314 NGKSVDRDGNPVGYGTGPV--GEPGTTDQHSFGQLLHQGTRDIPVTFIAVAEPHHDI----PDLLLANL--QGLALLAGK 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 435 TLDEARAQLQAKnlpasqveriAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKE 514
Cdd:COG0166  386 TLDEVLALAAEA----------TPHALFPGNRPSNTILLPKLTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKK 455
                        490       500       510
                 ....*....|....*....|....*....|.
gi 479816257 515 LATELLPVVSGKEGASGrdASTQGLVAHLHA 545
Cdd:COG0166  456 LAFALLGKLGGEEAAAG--DSTEALLKRLRA 484
PGI pfam00342
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ...
51-540 0e+00

Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.


Pssm-ID: 395271  Cd Length: 487  Bit Score: 695.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257   51 DWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFA 130
Cdd:pfam00342   1 DYSKNHINDEILTALVKLAEERGVDAAREAMFNGEKINSTENRAVLHVALRNRSNTPIYVDGKDVMPEVNAVLAKMKSFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  131 DGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHD-GPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTF 209
Cdd:pfam00342  81 ERVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALKPYSGrDLDVHFVSNVDGTHIAEVLKKLNPETTLFIVASKTF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  210 TTIETMTNAQTARKWVADTLGE-AAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNF 288
Cdd:pfam00342 161 TTAETMTNAESAKEWLLKALKDdSAVAKHFIALSTNAEKVEEFGIDTKNMFEFWDWVGGRYSLWSAIGLPIALSIGFENF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  289 RKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSG 368
Cdd:pfam00342 241 QQLLEGAHAMDKHFLSAPPEKNIPVLLALLGVWYNNFFGAQTHAILPYDQYLHRFPAYLQQLDMESNGKYVTRDGVLVDH 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  369 PTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQaknl 448
Cdd:pfam00342 321 QTGPIIFGEPGTNGQHAFYQLIHQGTRLIPCDFIGAVQSQNPENGDHHKILLSNFFAQTEALMVGKSPEEVRKELA---- 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  449 pASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEG 528
Cdd:pfam00342 397 -AADVEHLIPHKTFTGNRPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVELGKVLAKSILPELENSNK 475
                         490
                  ....*....|..
gi 479816257  529 ASGRDASTQGLV 540
Cdd:pfam00342 476 VSSHDSSTNGLI 487
PLN02649 PLN02649
glucose-6-phosphate isomerase
14-549 0e+00

glucose-6-phosphate isomerase


Pssm-ID: 215351 [Multi-domain]  Cd Length: 560  Bit Score: 636.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  14 KLKKHWAESAPRDMRAAFsADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDR 93
Cdd:PLN02649  16 RLVAHVYQIKKTHLRELL-NDAERCQSMIAEFDGIYLDYSRQRVTDETMELLFPLAEAANLFEKIEAMFSGEIINSTEDR 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  94 AVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHD 173
Cdd:PLN02649  95 AVLHVALRAPRLAPILVDGKNVVPEVWEVLDKIKAFSEDVRSGKWKGATGKRFTNVVSIGIGGSFLGPLFVHEALATDPE 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 174 ------GPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDK 247
Cdd:PLN02649 175 alksakGRKLRFLANVDPVDIARQIAQLDPETTLVVVVSKTFTTAETMLNARTVRKWLRDALGGLAVAKHMVAVSTNLLL 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 248 VAAFGIPEDRVFGFWDWVGGRYSVWSAIG-LPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAIC 326
Cdd:PLN02649 255 VNKFGIDPWNAFPFWDWVGGRYSVCSAVGlLPLSLQYGFDVVEEFLEGAASMDEHFRTAPLKENIPVLLGLLSVWNSSFL 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 327 GYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTdTIPLEFIVAAK 406
Cdd:PLN02649 335 GYPARAILPYSQALLKFAPHIQQLDMESNGKGVDLDGNPLPVNTGEIDFGEPGTNGQHSFYQLIHQGR-NIPCDFIGVVR 413
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 407 GHEPTLDHQ------HEMLMANCLAQSEALMKGRTLDearaQLQAKNLPASQVeriaPHRVFSGNRPSLTLIHDMLDPYA 480
Cdd:PLN02649 414 SQQPVHLWLgegvsnHDELMSNFFAQPDALAYGKTPE----QLRAEGVPEELI----PHKVFAGNRPSLSILLPELTAYT 485
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 479816257 481 LGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGK----EGASGRDASTQGLVAHLHARRKA 549
Cdd:PLN02649 486 VGQLLALYEHRVAVQGFIWNINSFDQWGVELGKALAKRVRAVLNEArtkgEPVEGFNSSTTALLNHYLANKRA 558
PTZ00430 PTZ00430
glucose-6-phosphate isomerase; Provisional
45-545 0e+00

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 185612  Cd Length: 552  Bit Score: 585.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  45 LDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLD 124
Cdd:PTZ00430  41 FKGVTLDLSRQRLDEETLKLLIELAEEAKLKEKIKDMFNGEKINTTENRAVLHTALRAPRGEKVVVDGKNVLEDVHEVLD 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 125 RMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDGPRA------HFVSNIDGAHIADTLSPLDPA 198
Cdd:PTZ00430 121 RIKKFSDKIRSGEILGSTGKKLKNVICIGIGGSYLGTEFVYEALRTYGEAREAskgrklRFLANVDPIDVRRATEGLDPE 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 199 STLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIG- 276
Cdd:PTZ00430 201 ETLVVIISKTFTTAETMLNAKTVRQWLLDNIKsKEALSKHLCAVSTNLKLTSEFGIPDENVFGFWDWVGGRFSVTSAVGi 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 277 LPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNG 356
Cdd:PTZ00430 281 LPLSIQFGYDIVQQFLNGCHDMDEHFRTAPLEENLPVLLGLTSFYNSTFLGYNCVAILPYCQALLKFPAHVQQLLMESNG 360
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 357 KSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTdTIPLEFIVAAKGHEPT-LDH----QHEMLMANCLAQSEALM 431
Cdd:PTZ00430 361 KSVTLDGNTLDYNTGEIYFGEPGTNGQHSFYQLLHQGR-VVPSEFIGFAKSQNPIkLLGepvsNHDELMSNFFAQPDALA 439
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 432 KGRTLDearaQLQAKNLPasqvERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVEL 511
Cdd:PTZ00430 440 FGKTYE----ELEKEGVP----EELIPHKVFPGNRPSLLLLFPELNPYTIGQLLALYEHRTVVEGFLWNINSFDQWGVEL 511
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 479816257 512 GKELATELLPVVSGKEGASGRDA-------STQGLVAHLHA 545
Cdd:PTZ00430 512 GKVLAKDVRNLFKDNRSNSSPHAkeskfngSTKRLLSYYLQ 552
pgi PRK14095
glucose-6-phosphate isomerase; Provisional
35-543 1.85e-143

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 237608  Cd Length: 533  Bit Score: 424.43  E-value: 1.85e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  35 PGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINN-----TEDRAVLHVALRDTSSKEVL 109
Cdd:PRK14095  34 EERIKKYSLSGEGFTYNYATERVDDRILAALQNLADEAELIEKMKAMQNGAVINRiegfpSENRPVLHTATRGQVGDSVL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 110 VD-GHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPY-HDGPRAHFVSNIDGAH 187
Cdd:PRK14095 114 TDeAEDMAEFSKRELERLAEFLKKVRSGEIKNSNGKKFTTVVQIGIGGSDLGPKALYLALKNYaKKDKRVHFISNVDPDD 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 188 IADTLSPLDPASTLIIVASKTFTTIETMTNAQtarkWVADTLGEAAVGA--HFAAVS---TALDKvaafgiPED--RVFG 260
Cdd:PRK14095 194 AAEVLSEIDLAKTLFIVVSKSGTTLETAANEE----FVRDALKKAGLDYkkHFIAVTsegSPMDD------ESGylEVFH 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 261 FWDWVGGRYSVWSAIGLPVM-IAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQR 339
Cdd:PRK14095 264 MWDSIGGRFSSTSMVGGVVLgFAFGFEVFKEFLKGAAAMDKAALNPNIRENLPLLAALIGIWNRNFLGYPTTAVIPYSQA 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 340 LSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAK---GHEPTLD--H 414
Cdd:PRK14095 344 LERFPAHLQQLDMESNGKSVNRFGEPINFKTGPIIWGEPGTNGQHSFFQLLHQGTDIVPVEFIGFKEsqlGQDIVIQgsT 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 415 QHEMLMANCLAQSEALMKGRtldearaqlqaknlpasqvERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFV 494
Cdd:PRK14095 424 SQQKLFANLIAQIIALACGK-------------------ENTNPNKNFKGNRPSSLLVAKQLTPYTLGALLAHYENKVMF 484
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 479816257 495 EAQIFGINAFDQWGVELGKELATELLPVVSGKEgaSGRDASTQGLVAHL 543
Cdd:PRK14095 485 QGFCWNINSFDQEGVQLGKVLANQILGIMKGEA--PGEFPEADGLLKLF 531
SIS_PGI_2 cd05016
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ...
330-519 2.13e-78

Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.


Pssm-ID: 240147  Cd Length: 164  Bit Score: 243.66  E-value: 2.13e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 330 SRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVsgPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHE 409
Cdd:cd05016    2 THALLPYSQRLERFPAWLQQLDMESNGKSVTRDGEDY--PTGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVKKPQN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 410 PTLD-----HQHEMLMANCLAQSEALMkgrtldearaqlqaknlpasqveriaphrvFSGNRPSLTLIHDMLDPYALGRL 484
Cdd:cd05016   80 DVLDylagkTLHDLLLANCLATREALM------------------------------FPGGRPSNTIVLPELTPYTLGAL 129
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 479816257 485 IALYEHRVFVEAQIFGINAFDQWGVELGKELATEL 519
Cdd:cd05016  130 LALYEHKTAVQGALLGINPFDQPGVELGKKLAKKI 164
SIS_PGI_1 cd05015
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ...
122-282 7.06e-73

Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.


Pssm-ID: 240146  Cd Length: 158  Bit Score: 228.95  E-value: 7.06e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 122 VLDRMAAFADGIRSGalkgatgRKITDIVNIGIGGSDLGPVMATLALAPY-HDGPRAHFVSNIDGAHIADTLSPLDPAST 200
Cdd:cd05015    3 ELERIKEFAEKVRSG-------KKITDVVVIGIGGSDLGPRAVYEALKPYfKGGLRLHFVSNVDPDDLAELLKKLDPETT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 201 LIIVASKTFTTIETMTNAQTARKWVADTLGEaAVGAHFAAVSTALDKVAA-FGIPEDRVFGFWDWVGGRYSV-WSAIGLP 278
Cdd:cd05015   76 LFIVISKSGTTLETLANARLAREWLEEAGGD-DLAKHFVAITDNGSGLLKkAGIEGLNTFEIPDWVGGRFSVlSSVGGLP 154

                 ....
gi 479816257 279 VMIA 282
Cdd:cd05015  155 LALA 158
pgi PRK14096
glucose-6-phosphate isomerase; Provisional
40-520 3.94e-57

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 237609 [Multi-domain]  Cd Length: 528  Bit Score: 199.34  E-value: 3.94e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257  40 RYS--LCLDD---LLFDWSKCRVNDETMALLKEL---AVAAdvegrRAAMFAGEHINNTEDRAVLHVALRDTSskevLVD 111
Cdd:PRK14096   9 RYCdwLYYHPelgLWLDISRMNFDDAFLESLEPKfqkAFAA-----MAALEAGAIANPDEGRMVGHYWLRNPE----LAP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 112 GHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDGPRAHFVSNIDGAHIADT 191
Cdd:PRK14096  80 TPEIRAEITETLAQIEAFAAKVHSGTIKPPNGEKFTDVLWIGIGGSALGPQFVAEALQPNSDGLNIHFIDNTDPDGIDRV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 192 LSPLDP--ASTLIIVASKTFTTIET---MTNAQTARKwvadtlgeaAVGAHFAAVSTA-------LDKVAafgIPED--R 257
Cdd:PRK14096 160 LAELGDrlATTLVVVISKSGGTPETrngMLEAKAAYE---------AAGLDFASHAVAitmkgskLDQLA---QSEGwlA 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 258 VFGFWDWVGGRYSVWSAIGLpVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNlPVMLgLIGYWHRAICGYGSR--AIIP 335
Cdd:PRK14096 228 RFPMWDWVGGRTSETSAVGL-LPAALQGIDIRAFLAGAKQMDEATRVPDLKNN-PAAL-LALAWYYAGDGKGKKdmVVLP 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 336 YDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSgpTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIvaakgheptldhq 415
Cdd:PRK14096 305 YKDRLLLFSRYLQQLVMESLGKELDLDGNVVH--QGIAVYGNKGSTDQHAYVQQLRDGVDNFFVTFI------------- 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 416 hEMLMANCLAQSEALMKGRTLDEARAQLQAKnlpasqveRIAphrVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVE 495
Cdd:PRK14096 370 -EVLEDRQGSSIEVEPGVTSGDYLSGFLQGT--------RQA---LYENGRQSITITIPEVNPRTLGALIALFERAVGLY 437
                        490       500
                 ....*....|....*....|....*
gi 479816257 496 AQIFGINAFDQWGVELGKELATELL 520
Cdd:PRK14096 438 ASLVNINAYHQPGVEAGKKAAAAIL 462
PRK00973 PRK00973
glucose-6-phosphate isomerase; Provisional
147-528 3.79e-44

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 179193 [Multi-domain]  Cd Length: 446  Bit Score: 162.47  E-value: 3.79e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 147 TDIVNIGIGGSDLGPVMATLALAPYH---------DGPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTN 217
Cdd:PRK00973  72 DNVVVLGIGGSALGNLALHYALNPLNwnelskeerNGPRVFVLDNVDPEKTASILDVIDLEKTLFNVISKSGNTAETLAN 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 218 AQTARKWVaDTLGEAAVGaHFAAVSTA----LDKVA------AFGIPEDrvfgfwdwVGGRYSVWSAIGLPVMIAVGPDn 287
Cdd:PRK00973 152 YLIIRGIL-EKLGLDPKK-HLVFTTDPekgkLKKIAekegyrTLEIPEN--------VGGRFSVLTPVGLAPAAALGID- 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 288 FRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWH--RaicGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKsvtlDGKp 365
Cdd:PRK00973 221 IEELLEGAKEMDKICEKEDIFKNPALLNALIHYLYynR---GKNISVMMPYSERLKYFGDWYRQLWAESLGK----KGV- 292
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 366 vsGPTgPVvwGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHE----PTLDHQHEMLmaNCLAqsealmkGRTLDEA-R 440
Cdd:PRK00973 293 --GQT-PV--KALGATDQHSQLQLYMEGPKDKIITFLKVEKYRRdveiPYEYEDIEEL--SYLG-------GHKLSELiN 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 441 AQLQAknlpasqVERIAPHRvfsgNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELL 520
Cdd:PRK00973 359 SEQKG-------TEIALTEN----GRPNVKITLDELNEYTVGQLFYMYEMQTAFMGELLNINAFDQPGVELGKKITYALL 427

                 ....*...
gi 479816257 521 pvvsGKEG 528
Cdd:PRK00973 428 ----GRSG 431
PRK03868 PRK03868
glucose-6-phosphate isomerase; Provisional
145-520 3.03e-25

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 235168  Cd Length: 410  Bit Score: 108.10  E-value: 3.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 145 KITDIVNIGIGGSDLGPVMATLALAPYHDGPRA-HFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMT------- 216
Cdd:PRK03868  57 SIKNIVVIGIGGSSLGVKAIYSFLKNEKNNKKElHFLENTDPISINKTLSKINLENTLFIVISKSGTTIETISifkylls 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 217 ----NAQTARKWVADTlGEAAVGAHFAAVstalDKVAAFGIPEDrvfgfwdwVGGRYSVWSAIGL-PVMIAvGPDnFRKF 291
Cdd:PRK03868 137 hfklDQELKKNFLFIT-DPDSKLEQFAKE----NNIKCFNIPKN--------VGGRFSVLSAVGIvPLALC-GYD-IKAL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 292 LAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRaicgYGSRAIIPYDQRLSRLPAYLQQLDMESNGKsvtLDG-KPVSGPT 370
Cdd:PRK03868 202 LEGAKACKDSFFEQKEDHILKKAYFYATHKNA----YNINVLFSYSDALKGFNDWYVQLWGESLGK---KQGyKTRVGLT 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 371 gPVvwGEPGTNGQHAFFQLLHQGT----------------DTIP---LEFIvaakghePTLDHQ-----HEMLMANCLAQ 426
Cdd:PRK03868 275 -PI--GLIGSRDQHSFLQLIMEGPrdktvtfikikdfqnaPKIPnisLKGL-------ESLDFVngvsfNELINAQCDAT 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 427 SEALMkgrtldearaqlqAKNLPasqVERIaphrvfsgnrpslTLihDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQ 506
Cdd:PRK03868 345 MEALI-------------AEDIP---VDVI-------------TL--EKLDEFSIGYLIYYYELLTSAVGKMLGINTYDQ 393
                        410
                 ....*....|....
gi 479816257 507 WGVELGKELATELL 520
Cdd:PRK03868 394 PGVEVGKRILKEKL 407
PRK09533 PRK09533
bifunctional transaldolase/phosoglucose isomerase; Validated
123-520 1.66e-24

bifunctional transaldolase/phosoglucose isomerase; Validated


Pssm-ID: 236551 [Multi-domain]  Cd Length: 948  Bit Score: 108.13  E-value: 1.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 123 LDRMAAFADGIRsgalkgatGRKITDIVNIGIGGSDLGP-VMATlaLAPYHDG-PRAHFVSNIDGAHIADTLSPLDPAST 200
Cdd:PRK09533 440 LAEYEAFAEEVR--------AEGFTDAVVLGMGGSSLGPeVLAE--TFGQRDGfPKLHVLDSTDPAQVRALEAAVDLART 509
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 201 LIIVASKTFTTIETMTNAQTARKWVADTLGEAAvGAHFAAVS---TALDKVAAfgipEDrvfGFWDW------VGGRYSV 271
Cdd:PRK09533 510 LFIVSSKSGGTLEPNIFKDYFFARVKEVLGAKA-GRHFVAVTdpgSSLEKVAK----ED---GFRKIfhgdpdIGGRYSV 581
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 272 WSAIGLPVMIAVGPDnFRKFLAGAHAMdVHF--RDAPLEKNLPVMLGLI-GywHRAICGYGSRAIIpYDQRLSRLPAYLQ 348
Cdd:PRK09533 582 LSPFGLVPAAAAGID-VRALLDSALAM-VRScgPSVPPADNPGVQLGLAlG--VAATQGRDKVTIV-ASPAIADFGAWAE 656
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 349 QLDMESNGKsvtlDGK---PVSGPTgpvvWGEPGTNGQHAFFqlLHQGTDTIPlefivaakgheptlDHQHEmlmancla 425
Cdd:PRK09533 657 QLIAESTGK----EGKgliPIDGEP----LGDPAVYGNDRVF--VYLRLAGEA--------------DAAQD-------- 704
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 426 qsealmkgrtldearAQLQAknlpasqVERiAPHRVFSgnrpsltliHDMLDPYALGRLIALYEHRVFVEAQIFGINAFD 505
Cdd:PRK09533 705 ---------------AALAA-------LEA-AGHPVVR---------IVLDSAEQLGQEFFRWEMATAVAGAVLGINPFD 752
                        410
                 ....*....|....*
gi 479816257 506 QWGVELGKELATELL 520
Cdd:PRK09533 753 QPDVEASKIKTRELT 767
pgi PRK14097
glucose-6-phosphate isomerase; Provisional
123-528 2.06e-14

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 184504  Cd Length: 448  Bit Score: 75.65  E-value: 2.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 123 LDRMAAFADGIRSgalkgatgrKITDIVNIGIGGSDLGPVMATLALA-PYH--------DGPRAHFVSN-IDGAHIADTL 192
Cdd:PRK14097  59 FARIKKAAEKIKS---------DSDVLVVIGIGGSYLGARAAIEFLNhSFYnllpkeqrKAPQIIFAGNsISSTYLADLL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 193 SPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLG-EAAVGAHFA---AVSTALDKVA------AFGIPEDrvfgfw 262
Cdd:PRK14097 130 EYLKDKDFSINVISKSGTTTEPAIAFRIFKELLEKKYGkEEAKKRIYAttdKAKGALKTLAdaegyeTFVIPDD------ 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 263 dwVGGRYSVWSAIGLPVMIAVGPDnFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYW-HRAicGYGSRAIIPYDQRLS 341
Cdd:PRK14097 204 --VGGRFSVLTAVGLLPIAVAGID-IDALMKGAADARKDYSSSDLSENPAYQYAAVRNIlYRK--GYTTEILVNYEPSLQ 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 342 RLPAYLQQLDMESNGKsvtlDGKpvsG--PTGPVVwgepgTNGQHAFFQLLHQGTDTIpLEFIVAAKG--HEPTLDHQHE 417
Cdd:PRK14097 279 YFSEWWKQLFGESEGK----DQK---GifPASANF-----STDLHSLGQYIQEGRRNL-FETVIKVEKprKDLTIPEDEE 345
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479816257 418 MLMA-NCLAqsealmkGRTLDEAraqlqakNLPASQVERIApHrvFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEA 496
Cdd:PRK14097 346 DLDGlNYLA-------GKTVDFV-------NKKAFEGTLLA-H--TDGGVPNIVVNIPELDEYTFGYLVYFFEKACAISG 408
                        410       420       430
                 ....*....|....*....|....*....|..
gi 479816257 497 QIFGINAFDQWGVELGKELATELLpvvsGKEG 528
Cdd:PRK14097 409 YLLGVNPFDQPGVEAYKKNMFALL----GKPG 436
SIS_TAL_PGI cd05798
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the ...
471-519 1.20e-03

SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a C-terminal PGI domain. TAL catalyzes the reversible conversion of sedoheptulose-7-phosphate (S7P) and glyceraldehyde-3-phosphate (G3P), to fructose-6-phosphate (F6P) and erythrose-4-phosphate (E4P). PGI catalyzes the reversible isomerization of F6P to glucose-6-phosphate (G6P). It has been suggested for Gluconobacter oxydans TAL_PGI that this enzyme generates E4P and G6P directly from S7P and G3P. G. oxydans TAL_PGI contributes to increased xylitol production from D-arabitol. As xylitol is an alternative natural sweetner to sucrose, the microbial conversion of D-arabitol to xylitol is of interest to food and pharmaceutical industries.


Pssm-ID: 240224 [Multi-domain]  Cd Length: 129  Bit Score: 38.97  E-value: 1.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 479816257 471 LIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATEL 519
Cdd:cd05798   81 IRIDLDDAYDLGQEFFRWEMATAVAGAVLGINPFDQPDVEASKIETRRL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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