|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
1-398 |
0e+00 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 780.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 1 MTTENARKFRPATELVHAGSLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGA 80
Cdd:PRK07504 1 MTTEMARKWRPATRLVHSGTLRSQFGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 81 EDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPS 160
Cdd:PRK07504 81 EDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 161 NPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFR 240
Cdd:PRK07504 161 NPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLQDYFR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 241 HTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGG 320
Cdd:PRK07504 241 HTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGG 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 479837353 321 KEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVARG 398
Cdd:PRK07504 321 KEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKVRA 398
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
10-396 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 573.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 10 RPATELVHAG-SLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATAS 88
Cdd:COG0626 2 GPATRAVHAGrDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 89 GMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIID 168
Cdd:COG0626 82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 169 IAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSP 248
Cdd:COG0626 162 IAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 249 FNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFE 328
Cdd:COG0626 242 FDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARRFL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 479837353 329 NALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVA 396
Cdd:COG0626 322 DALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
12-393 |
0e+00 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 548.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 12 ATELVHAGSLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMA 91
Cdd:TIGR01325 1 ATLAVRGGMLRSGFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 92 AVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAA 171
Cdd:TIGR01325 81 AIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 172 VAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNA 251
Cdd:TIGR01325 161 VAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 252 WIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELeGGKEAAFKFENAL 331
Cdd:TIGR01325 241 WVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDL-DCRQAAFKVLDAM 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479837353 332 QIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:TIGR01325 320 RLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
8-394 |
0e+00 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 513.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 8 KFRPATELVHAGSLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATA 87
Cdd:PRK08133 4 SLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 88 SGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEII 167
Cdd:PRK08133 84 SGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 168 DIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQdYFRHTGPGLS 247
Cdd:PRK08133 164 DIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFG-FLRTAGPTLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 248 PFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKF 327
Cdd:PRK08133 243 PFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWRV 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 479837353 328 ENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PRK08133 323 IDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLA 389
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
10-394 |
0e+00 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 513.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 10 RPATELVHAGSLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASG 89
Cdd:PRK07810 15 SQATIGVRGGLLRSGFEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 90 MAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDI 169
Cdd:PRK07810 95 MSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 170 AAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPF 249
Cdd:PRK07810 175 AAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 250 NAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEG----GKEAAF 325
Cdd:PRK07810 255 NAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDApedaAKKRAF 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 479837353 326 KFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PRK07810 335 EVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
12-394 |
1.89e-161 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 458.24 E-value: 1.89e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 12 ATELVHAGSLRS-GFAEMSEALFLTQGFLYPTAeaaearfkGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGM 90
Cdd:pfam01053 1 DTLAVHAGQRPDpQTGAVSVPIYLTSTYVFDFA--------GEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 91 AAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIA 170
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 171 AVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFN 250
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 251 AWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENA 330
Cdd:pfam01053 233 AWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDN 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 479837353 331 LQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:pfam01053 313 LKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
28-394 |
1.03e-152 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 435.86 E-value: 1.03e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 28 MSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHV 107
Cdd:cd00614 3 VAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 108 ISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDN 187
Cdd:cd00614 83 VASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 188 VFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQ 267
Cdd:cd00614 163 TFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMER 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 268 QTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLI 347
Cdd:cd00614 243 HSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLV 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 479837353 348 THPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:cd00614 323 EHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-397 |
1.50e-142 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 412.12 E-value: 1.50e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 1 MTTenaRKFRPATELVHAGSlRSGFAEMSEAL--FLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALE 78
Cdd:COG2873 1 MTE---KKYGFETLALHAGQ-EPDPTTGARAVpiYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 79 GAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLES 158
Cdd:COG2873 77 GGVAALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGET 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 159 PSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVL---------SDR- 228
Cdd:COG2873 157 IGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVdggnfdwaaNGKf 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 229 -------------EWIET----------TLQdYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGV 285
Cdd:COG2873 237 peltepdpsyhglVYTEAfgnaafitkaRVQ-LLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 286 KRVIYPGRADHPQADIIAKQMTGG-STLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKA 364
Cdd:COG2873 316 AWVNYPGLPSHPYHELAQKYLPKGaGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQA 395
|
410 420 430
....*....|....*....|....*....|...
gi 479837353 365 ELGISDGLLRVSVGLEDTDDLLEDVEVALKVAR 397
Cdd:COG2873 396 AAGVTPDLIRLSVGIEDIDDIIADLDQALAAAT 428
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
10-394 |
2.60e-119 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 352.82 E-value: 2.60e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 10 RPATELVHAGSLRSGfAEMSEAL--FLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATA 87
Cdd:TIGR01326 1 HFETLQLHAGQEPDP-TTGSRAVpiYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 88 SGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEII 167
Cdd:TIGR01326 80 SGQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 168 DIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVL-------SDREWIETTLQD--- 237
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwNNGRFPLFTTPDpsy 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 238 ---------------------YFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADH 296
Cdd:TIGR01326 240 hglvftetlgnpafilkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 297 PQADIIAKQMTGG-STLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRV 375
Cdd:TIGR01326 320 PHHALAKKYLPKGfGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*....
gi 479837353 376 SVGLEDTDDLLEDVEVALK 394
Cdd:TIGR01326 400 SVGIENIDDIIADLEQALE 418
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
4-393 |
8.61e-118 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 348.36 E-value: 8.61e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 4 ENARKFRPATELVHAGSLR-SGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAED 82
Cdd:PRK06234 2 ENIKKMGFATKAIHGGHIGdKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 83 ARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNP 162
Cdd:PRK06234 82 AVVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 163 TLEIIDIAAVAQIANEA--GAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWI-ETTLQDYF 239
Cdd:PRK06234 162 TLKVTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFInQVKLFGIK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 240 RHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEG 319
Cdd:PRK06234 242 DMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKG 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 479837353 320 GKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK06234 322 GVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
32-397 |
1.82e-113 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 337.16 E-value: 1.82e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 32 LFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISAR 111
Cdd:PRK07503 32 VYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLWTLLRPGDEVIVDQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 112 AVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFAT 191
Cdd:PRK07503 112 TLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTYCT 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 192 PLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWI-ETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQ 270
Cdd:PRK07503 192 PYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALAdRIRLEGLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 271 SAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHP 350
Cdd:PRK07503 272 SAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHP 351
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 479837353 351 ATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVAR 397
Cdd:PRK07503 352 ASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACA 398
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
7-394 |
1.43e-108 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 324.10 E-value: 1.43e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 7 RKFRPATELVHAG-SLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARA 85
Cdd:PRK06767 2 KKKHMETALIHHGyTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 86 TASGMAAVAAAILCQVQAGDHVISARAVFGsCRYIVETVLP-RYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTL 164
Cdd:PRK06767 82 FGSGMAAISATLIGFLKAGDHIICSNGLYG-CTYGFLEVLEeKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 165 EIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGP 244
Cdd:PRK06767 161 KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 245 GLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYpgradhPQADIIAKQMTGGSTLIALELEGGKEAA 324
Cdd:PRK06767 241 IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEET 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 325 FKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PRK06767 315 QAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
56-393 |
8.52e-108 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 322.36 E-value: 8.52e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 56 GFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSII 135
Cdd:PRK07811 52 GYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPV 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 136 DGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDG 215
Cdd:PRK07811 132 DLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 216 QGRCLGG-VVLSDREWIETT--LQDyfrHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPG 292
Cdd:PRK07811 212 HSDVVGGaLVTNDEELDEAFafLQN---GAGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPG 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 293 RADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHknlSNEAKAELGISDGL 372
Cdd:PRK07811 289 LPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTH---ASTAGSQLEVPDDL 365
|
330 340
....*....|....*....|.
gi 479837353 373 LRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK07811 366 VRLSVGIEDVADLLADLEQAL 386
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
32-396 |
8.95e-106 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 318.61 E-value: 8.95e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 32 LFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISAR 111
Cdd:PRK08134 31 IHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLAIATLMGAGSHIVASS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 112 AVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFAT 191
Cdd:PRK08134 111 ALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAHEAGVPLLVDSTFTT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 192 PLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLS--DREW-----IETTLQDY-------------------------F 239
Cdd:PRK08134 191 PYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDggRFDWeasgkFPELTEPYagfhgmvfaeestvaafllrarregL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 240 RHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADiIAKQM--TGGSTLIALEL 317
Cdd:PRK08134 271 RDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHA-LAKRLlpRGAGSVFSFDL 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 479837353 318 EGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVA 396
Cdd:PRK08134 350 KGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
13-398 |
2.44e-105 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 317.85 E-value: 2.44e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 13 TELVHAGSLRSGfAEMSEAL--FLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGM 90
Cdd:PRK07812 16 TKQIHAGQTPDP-ATNARALpiYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 91 AAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSII-DGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDI 169
Cdd:PRK07812 95 AAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 170 AAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDR--EWIETTLQDY--------- 238
Cdd:PRK07812 175 PGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGtfDWTQGRFPGFttpdpsyhg 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 239 -------------------FRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQA 299
Cdd:PRK07812 255 vvfaelgppayalkarvqlLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWY 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 300 DiIAKQMT--GGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSV 377
Cdd:PRK07812 335 E-RAKRLApkGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAV 413
|
410 420
....*....|....*....|.
gi 479837353 378 GLEDTDDLLEDVEVALKVARG 398
Cdd:PRK07812 414 GIEGIDDILADLEAGFAAAKA 434
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
52-397 |
4.37e-101 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 305.51 E-value: 4.37e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 52 GEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVE 131
Cdd:PRK08249 51 GKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVD 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 132 VSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATK 211
Cdd:PRK08249 131 VTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATK 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 212 HIDGQGRCLGGVVLSDREWIETTLQdYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYP 291
Cdd:PRK08249 211 FLSGHADALGGVVCGSKELMEQVYH-YREINGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYP 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 292 GRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDG 371
Cdd:PRK08249 290 GLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEG 369
|
330 340
....*....|....*....|....*.
gi 479837353 372 LLRVSVGLEDTDDLLEDVEVALKVAR 397
Cdd:PRK08249 370 LVRISVGIEDTEDLIADLEQAFAHLE 395
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
52-394 |
1.99e-99 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 300.49 E-value: 1.99e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 52 GEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAaILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVE 131
Cdd:PRK07671 37 GKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITA-VMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 132 VSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATK 211
Cdd:PRK07671 116 HTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 212 HIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYP 291
Cdd:PRK07671 196 YLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYP 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 292 GRADHPQADIIAKQMTGGSTLIALELeGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDG 371
Cdd:PRK07671 276 GLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDG 354
|
330 340
....*....|....*....|...
gi 479837353 372 LLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PRK07671 355 LIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
7-397 |
7.15e-99 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 300.99 E-value: 7.15e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 7 RKFRPATELVHAG-SLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARA 85
Cdd:PRK08248 5 RTFRLETLAIHAGqEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 86 TASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLE 165
Cdd:PRK08248 85 VSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 166 IIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVL---------SDR-------- 228
Cdd:PRK08248 165 VLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgSGKfpgltepd 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 229 ---------------EWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGR 293
Cdd:PRK08248 245 psyhglvytdavgeaAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 294 ADHPQADIIAKQMTGGS-TLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGL 372
Cdd:PRK08248 325 PSHPSYELAKKYLPKGQgAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGL 404
|
410 420
....*....|....*....|....*
gi 479837353 373 LRVSVGLEDTDDLLEDVEVALKVAR 397
Cdd:PRK08248 405 VRLSVGTEAIDDILDDLRQAIRQSQ 429
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
59-398 |
2.64e-92 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 282.82 E-value: 2.64e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 59 YSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQaGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGS 138
Cdd:PRK08064 48 YSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFLLLSK-GDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 139 DVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGR 218
Cdd:PRK08064 127 NLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSD 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 219 CLGGV-VLSDREWIET--TLQDYFrhtGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRAD 295
Cdd:PRK08064 207 VLAGLaVVKDEELAQKlyFLQNSF---GAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQT 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 296 HPQADIIAKQMTGGSTLIALELEgGKEAAFKF-ENA-LQIFSITnnLGDTKSLITHPATTTHKNLSNEAKAELGISDGLL 373
Cdd:PRK08064 284 HLGFDIQQSQATSAGAVLSFTLQ-SEEAVRQFvSHVkLPVFAVS--LGAVESILSYPAKMSHAAMPKEERDERGITDGLL 360
|
330 340
....*....|....*....|....*
gi 479837353 374 RVSVGLEDTDDLLEDVEVALKVARG 398
Cdd:PRK08064 361 RLSVGLENVDDLIADFEQALSYVEE 385
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
4-390 |
8.33e-92 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 282.92 E-value: 8.33e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 4 ENARKFRPATELVHAG-SLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAED 82
Cdd:PRK05613 7 SNADQWGFETRSIHAGqSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 83 ARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDG-SDVANWKAAVRPNTKVMFLESPSN 161
Cdd:PRK05613 87 AVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENpDDPESWQAAVQPNTKAFFGETFAN 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 162 PTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQD---- 237
Cdd:PRK05613 167 PQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTVERDgkpv 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 238 --YF-----------------------------RHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVK 286
Cdd:PRK05613 247 fpYFvtpdpayhglkyadlgapafglkaragllRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 287 RVIYPGRADHPQADIIAK---QMTGgsTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAK 363
Cdd:PRK05613 327 KVNFAGLKDSPWYATKEKlglKYTG--SVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGL 404
|
410 420
....*....|....*....|....*..
gi 479837353 364 AELGISDGLLRVSVGLEDTDDLLEDVE 390
Cdd:PRK05613 405 ARAGITQATVRLSVGIEDIDDIIADLE 431
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
2-393 |
4.03e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 278.48 E-value: 4.03e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 2 TTENARKFRPATELvhagsLRSGF-AEMSEA-----LFLTQGFLYPTAEAAEARF----------KGEDPGFIYSRYANP 65
Cdd:PRK07049 9 THIGNRELHPETQM-----LNYGYdPELSEGavkppVFLTSTFVFRSAEDGRDFFdyvsgrkeppAGEGAGLVYSRFNHP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 66 TTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVE-VSIIDGSD----- 139
Cdd:PRK07049 84 NSEIVEDRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSeaaig 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 140 VANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAK------LIVDNVFATPLFQKPLELGAHIVVYSATKHI 213
Cdd:PRK07049 164 AAAEAAAAKGRVSLILIETPANPTNSLVDVAAVRRVADAIEARqghrpiIACDNTLLGPVFQKPLEHGADLSVYSLTKYV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 214 DGQGRCLGGVVLSDREWIETTlqDYFRHT-GPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPG 292
Cdd:PRK07049 244 GGHSDLVAGAVLGRKALIRQV--RALRSAiGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 293 --RADHPQADIIAKQMTG-GSTLiALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGIS 369
Cdd:PRK07049 322 flDPDSAYGAVYKRQCTGaGSTF-SFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVL 400
|
410 420
....*....|....*....|....
gi 479837353 370 DGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK07049 401 ESTIRLSIGIEHPDDLIADLAQAL 424
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
40-395 |
6.17e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 276.56 E-value: 6.17e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 40 YPTAEAAEARFKGE----DPGFI--YSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAV 113
Cdd:PRK08574 22 PPIYLTALFRQEGEaypsDRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLFFSLLKAGDRVVLPMEA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 114 FGSCRYIVETvLPRYGVEVSII--DGSDVANwkAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFAT 191
Cdd:PRK08574 102 YGTTLRLLKS-LEKFGVKVVLAypSTEDIIE--AIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNTFAT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 192 PLFQKPLELGAHIVVYSATKHIDGQGRCLGG-VVLSDREWIEtTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQ 270
Cdd:PRK08574 179 PLLYRPLRHGADFVVHSLTKYIAGHNDVVGGvAVAWSGEFLE-ELWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFERQCR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 271 SAAAIADFLAGKPGVKRVIYPGRADHPQADI----IAKQMTGGstLIALELEGGKEAAFKFENALQIFSITNNLGDTKSL 346
Cdd:PRK08574 258 NAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVakrlFGKDLYGG--VVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESL 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 479837353 347 ITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKV 395
Cdd:PRK08574 336 ATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
10-398 |
1.87e-88 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 274.09 E-value: 1.87e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 10 RPATELVHAG-SLRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATAS 88
Cdd:PRK06084 2 KLETLAIHAGySPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 89 GMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIID 168
Cdd:PRK06084 82 GMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 169 IAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYF--------- 239
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKERFallntpdps 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 240 ------------------------RHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRAD 295
Cdd:PRK06084 242 yhgvtyteafgpaafigrcrvvplRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 296 HPQADIIAKQMTGG-STLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLR 374
Cdd:PRK06084 322 HPEHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|....
gi 479837353 375 VSVGLEDTDDLLEDVEVALKVARG 398
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDASKG 425
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
35-396 |
3.40e-88 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 273.51 E-value: 3.40e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 35 TQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVF 114
Cdd:PRK05994 33 TTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASGHAAQFLVFHTLLQPGDEFIAARKLY 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 115 GSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLF 194
Cdd:PRK05994 113 GGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIAAIAEVAHRAGLPLIVDNTLASPYL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 195 QKPLELGAHIVVYSATKHIDGQGRCLGGVVL---------SDR---------EWIETTLQDYF--------------RHT 242
Cdd:PRK05994 193 IRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwskSGKypmlseprpEYHGLVLHETFgnfafaiaarvlglRDL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 243 GPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADiIAKQMT--GGSTLIALELEGG 320
Cdd:PRK05994 273 GPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPYHA-LAQKYSpkGAGAVFTFGLKGG 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 479837353 321 KEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVA 396
Cdd:PRK05994 352 YEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
25-397 |
7.63e-88 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 271.18 E-value: 7.63e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 25 FAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAG 104
Cdd:PRK05968 23 FDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSFVEPG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 105 DHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVrPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLI 184
Cdd:PRK05968 103 DRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAALAKRHGVVTM 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 185 VDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVR 264
Cdd:PRK05968 182 IDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYLGAKLSPFEAWLLLRGLRTLPLR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 265 VRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADiiakqMTGGSTLIALELEGGKEAAfKFENALQIFSITNNLGDTK 344
Cdd:PRK05968 262 MKAHEASALEIARRLKAHPVVERVCHPALANHPPAG-----LSGTSGLFSFIFREGIDVR-AFADALKLFRLGVSWGGHE 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 479837353 345 SLIThPATTThknLSNEAK----AELGISDGLLRVSVGLEDTDDLLEDVEVALKVAR 397
Cdd:PRK05968 336 SLVV-PAEVV---LQQKAQpnsaARFGVSPRSVRLHVGLEGTEALWADLEQALAAAS 388
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
52-394 |
7.35e-85 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 262.72 E-value: 7.35e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 52 GEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAaILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVE 131
Cdd:PRK08247 39 GESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQL-VMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 132 VSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATK 211
Cdd:PRK08247 118 FVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 212 HIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYP 291
Cdd:PRK08247 198 YLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 292 GRadhpqadiiakqmtGGSTLIALELEggkEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDG 371
Cdd:PRK08247 278 GR--------------GGMLSFRLQDE---EWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNR 340
|
330 340
....*....|....*....|...
gi 479837353 372 LLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PRK08247 341 LLRFSVGIENVEDLIADLKQAFK 363
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
38-396 |
9.38e-85 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 263.47 E-value: 9.38e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 38 FLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSC 117
Cdd:PRK05939 20 YGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSSQFLFGNT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 118 RYIVETvLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKP 197
Cdd:PRK05939 100 NSLFGT-LRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWLFRP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 198 LELGAHIVVYSATKHIDGQGRCLGGVV----LSDREWIETTLQDY-----------------FRHTGPGLSPFNAWIMLK 256
Cdd:PRK05939 179 KDVGASLVINSLSKYIAGHGNALGGAVtdtgLFDWSAYPNIFPAYrkgdpqqwgltqirkkgLRDMGATLSSEAAHRIAI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 257 GLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGkEAAFKFENALQIFSI 336
Cdd:PRK05939 259 GAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADG-IDCFDFLNRLKLVIK 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 337 TNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVA 396
Cdd:PRK05939 338 ATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
59-396 |
9.54e-85 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 263.29 E-value: 9.54e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 59 YSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGS 138
Cdd:PRK08045 46 YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 139 DVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGR 218
Cdd:PRK08045 126 DEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSD 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 219 CLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQ 298
Cdd:PRK08045 206 VVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 299 ADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVG 378
Cdd:PRK08045 286 HEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTG 365
|
330
....*....|....*...
gi 479837353 379 LEDTDDLLEDVEVALKVA 396
Cdd:PRK08045 366 IEDGEDLIADLENGFRAA 383
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
52-393 |
9.77e-85 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 262.91 E-value: 9.77e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 52 GEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAaILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVE 131
Cdd:PRK06176 37 GRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA-VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 132 VSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATK 211
Cdd:PRK06176 116 CTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 212 HIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYP 291
Cdd:PRK06176 196 YLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYP 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 292 GRADHPQADIIAKQMTGGSTLIALELEgGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDG 371
Cdd:PRK06176 276 GLPTHPNHELAKKQMRGFSGMLSFTLK-NDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDG 354
|
330 340
....*....|....*....|..
gi 479837353 372 LLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK06176 355 LVRLSVGIEHEQDLLEDLEQAF 376
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
11-396 |
2.35e-80 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 251.67 E-value: 2.35e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 11 PATELVHAGSLRSGFAEMSEALFLTQGFLYPTAEaaearfkgEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGM 90
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAI--------ENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 91 AAVAAaILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIA 170
Cdd:TIGR01329 73 AALDV-ITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 171 AVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLqdYF--RHTGPGLSP 248
Cdd:TIGR01329 152 KISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKV--YFlqNSTGSGLAP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 249 FNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALElEGGKEAAFKFE 328
Cdd:TIGR01329 230 FDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALSKRLV 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 479837353 329 NALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALKVA 396
Cdd:TIGR01329 309 EATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
32-393 |
7.39e-78 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 245.13 E-value: 7.39e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 32 LFLTQGFLYPTAEAaearfkgedpgFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISAR 111
Cdd:PRK06460 23 IYQTTAYHYPEGEK-----------YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNSVLVHR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 112 AVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFAT 191
Cdd:PRK06460 92 DMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFST 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 192 PLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIeTTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQS 271
Cdd:PRK06460 172 PINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLL-NVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRN 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 272 AAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPA 351
Cdd:PRK06460 251 AEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 479837353 352 TTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK06460 331 TMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
25-394 |
2.07e-77 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 246.86 E-value: 2.07e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 25 FAEMSEALFLTQGFLYPTAEaaearfkgEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAaILCQVQAG 104
Cdd:PLN02509 101 FDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 105 DHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLI 184
Cdd:PLN02509 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVL 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 185 VDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLqdYFRHT--GPGLSPFNAWIMLKGLETLS 262
Cdd:PLN02509 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEV--YFLQNseGSGLAPFDCWLCLRGIKTMA 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 263 VRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALeLEGGKEAAFKFENALQIFSITNNLGD 342
Cdd:PLN02509 330 LRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGS 408
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 479837353 343 TKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PLN02509 409 VKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
59-397 |
5.01e-77 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 244.13 E-value: 5.01e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 59 YSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGS 138
Cdd:PRK08776 54 YTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 139 DVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGR 218
Cdd:PRK08776 134 DPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSD 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 219 CLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQ 298
Cdd:PRK08776 214 VVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPG 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 299 ADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVG 378
Cdd:PRK08776 294 HALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVG 373
|
330
....*....|....*....
gi 479837353 379 LEDTDDLLEDVEVALKVAR 397
Cdd:PRK08776 374 IESAEDLLIDLRAGLARAE 392
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
52-398 |
1.24e-76 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 242.49 E-value: 1.24e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 52 GEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVE 131
Cdd:PRK08861 40 GEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 132 VSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATK 211
Cdd:PRK08861 120 VQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTK 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 212 HIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYP 291
Cdd:PRK08861 200 YINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHP 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 292 GRADHPQADIIAKQMTGGSTLIALELEGGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDG 371
Cdd:PRK08861 280 SLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQ 359
|
330 340
....*....|....*....|....*..
gi 479837353 372 LLRVSVGLEDTDDLLEDVEVALKVARG 398
Cdd:PRK08861 360 LLRLSVGLEDAQDLIADLDQAFAKAAE 386
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
13-393 |
3.15e-76 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 241.34 E-value: 3.15e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 13 TELVHAGSLR-SGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMA 91
Cdd:PRK06434 11 TRAVQSGELRdPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 92 AVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVAN--WKAAvrpNTKVMFLESPSNPTLEIIDI 169
Cdd:PRK06434 91 AITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSldFDPS---NYDLIYAESITNPTLKVPDI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 170 AAVAQIANEAgaKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPF 249
Cdd:PRK06434 168 KNVSSFCHEN--DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 250 NAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGradhpqADIIAKQMTGGSTLIALELEgGKEAAFKFEN 329
Cdd:PRK06434 246 QAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPD------TEIGKKVLRGFGGMLSFELR-SMEDVHKFIR 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 479837353 330 ALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK06434 319 NLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
59-396 |
5.00e-72 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 229.88 E-value: 5.00e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 59 YSRYANPTTDMFEKRMCALEGAEdARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGS 138
Cdd:PRK07582 45 YGRASNPTWRALEAALGELEGAE-ALVFPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 139 DVAnwkAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGR 218
Cdd:PRK07582 124 GMA---EAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSD 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 219 CLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQ 298
Cdd:PRK07582 201 LLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 299 ADIIAKQMTGGSTLIALELeGGKEAAFKFENALQIFSITNNLGDTKSlithpattthknlSNEAKAELG--ISDGLLRVS 376
Cdd:PRK07582 281 HEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVVAATSFGGVHT-------------SADRRARWGdaVPEGFVRLS 346
|
330 340
....*....|....*....|
gi 479837353 377 VGLEDTDDLLEDVEVALKVA 396
Cdd:PRK07582 347 CGIEDTDDLVADLERALDAL 366
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
52-394 |
1.57e-69 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 223.16 E-value: 1.57e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 52 GEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAiLCQVQAGDHVISARAVF-GSCRYIVET-VLPRYG 129
Cdd:PRK07269 41 GQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLA-FSVFPVGSKVVAVRDLYgGSFRWFNQQeKEGRFH 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 130 VEVSIIDgsdvANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSA 209
Cdd:PRK07269 120 FTYANTE----EELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 210 TKHIDGQGRCLGGVVLSDREWIETTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVI 289
Cdd:PRK07269 196 TKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 290 YPGRadhpqadiiakqmtGGstLIALELEgGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGIS 369
Cdd:PRK07269 276 YTGK--------------GG--MISFKVA-DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLT 338
|
330 340
....*....|....*....|....*
gi 479837353 370 DGLLRVSVGLEDTDDLLEDVEVALK 394
Cdd:PRK07269 339 DDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
11-394 |
1.82e-61 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 203.84 E-value: 1.82e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 11 PATELVHAgslRSGFAE-----MS-EAlflTQGFLYPTAEAAEARFKGE---DPGF-IYSRYANPTTDMFEKRMCALEGA 80
Cdd:PLN02242 18 PAAALASA---RHEFGEhggvnMSiEA---SATFTVMEPDTMRRMFSGElgpDRDFyIYSRHFNPTVLNLGRQMAALEGT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 81 EDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPR-YGVEVSIIDGSDVANWKAAVRPN-TKVMFLES 158
Cdd:PLN02242 92 EAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVPGkTKVLYFES 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 159 PSNPTLEIIDIAAVAQIANEAGAKLIVDNVFAtPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQdy 238
Cdd:PLN02242 172 ISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNSMMD-- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 239 FRH-----TGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAgKPGVKrVIYPGRADHPQADIIAKQMT---GGS 310
Cdd:PLN02242 249 LHHgalmlLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMK-ELGLK-VIYPGLEDHPQHALLKSMANkgyGFG 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 311 TLIALELeGGKEAAFKFENALQIFS----ITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVG----LEDT 382
Cdd:PLN02242 327 GLLCLDM-DTEERANRLMRYLQNSTqfgfMAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGytgtLEQR 405
|
410
....*....|..
gi 479837353 383 DDLLEDVEVALK 394
Cdd:PLN02242 406 WSQFEKALSAMK 417
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
39-398 |
5.69e-61 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 201.96 E-value: 5.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 39 LYPTAEAAEARfkgeDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCR 118
Cdd:PRK05967 42 LFPDAETMATR----GQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 119 YIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPL 198
Cdd:PRK05967 118 HFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 199 ELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIEtTLQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADF 278
Cdd:PRK05967 198 DFGVDISIHAATKYPSGHSDILLGTVSANEKCWP-QLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARW 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 279 LAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTL----IALELEGGKEAAFKFENALQIFSITNNLGDTKSLithpatTT 354
Cdd:PRK05967 277 LEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIfsfvLAAGPEKGKAKAHAFLDALEIFGLGYSWGGYESL------AL 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 479837353 355 HKNLSNEAKAElGISDG-LLRVSVGLEDTDDLLEDVEVALKVARG 398
Cdd:PRK05967 351 HVKLGDRTVAK-APYAGpVIRLQIGLEDVPDLKADLERGFAAASA 394
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
32-393 |
1.16e-59 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 199.51 E-value: 1.16e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 32 LFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISAR 111
Cdd:PRK06702 28 LYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLNICSSGDHLLCSS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 112 AVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAV-RPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFA 190
Cdd:PRK06702 108 TVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALaNDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 191 TPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLS--DREWIE----------------TTLQDY-------------F 239
Cdd:PRK06702 188 TPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDggNFDWTNgkypelvepdpsyhgvSYVQNFgaaayivkarvqlL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 240 RHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMT-GGSTLIALELE 318
Cdd:PRK06702 268 RDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKkGASGVLTFGIK 347
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 479837353 319 GGKEAAFKFENALQIFSITNNLGDTKSLITHPATTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK06702 348 GGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
1-393 |
3.24e-52 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 179.15 E-value: 3.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 1 MTTENARKFrPATELVHAGS-LRSGFAEMSEALFLTQGFLYPTAEAAEARFKGEDPGFIYSRYANPTTDMFEKRMCALEG 79
Cdd:PRK07050 1 MTASTPKRA-LQTRIVQPDDqIPPGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 80 AEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESP 159
Cdd:PRK07050 80 GRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 160 SNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDREWIETTLQDYF 239
Cdd:PRK07050 160 GSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLAR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 240 RHTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIALELEG 319
Cdd:PRK07050 240 MRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDE 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 479837353 320 G--KEAAFKFENALQIFSITNNLGDTKSLithpatTTHKNLSNEAKAELGISDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK07050 320 RysPAQVDAFVEALELFAIGWSWGGACSL------AMPYDVASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQAL 389
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
45-393 |
1.86e-49 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 171.84 E-value: 1.86e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 45 AAEARFKGEdpgFIYSRYANPTTDMFEKRMCALEGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETV 124
Cdd:PRK09028 44 AAKNRANGE---MFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 125 LPRYGVEVSIIDGSDVANWKAAVRPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATPLFQKPLELGAHI 204
Cdd:PRK09028 121 LKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDI 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 205 VVYSATKHIDGQGRC-LGGVVLSDREWIETTLQDYFrhTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKP 283
Cdd:PRK09028 201 SIQAATKYIVGHSDVmLGTATANEKHWDQLREHSYL--MGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRP 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 284 GVKRVIYPGRADHPQADIIAKQMTGGSTLIALEL-EGGKEAAFKFENALQIFSITNNLGDTKSLIThpATTTHKNLSNEA 362
Cdd:PRK09028 279 EVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLkQGDPKAVTALVEGMQHFKMGFSWGGFESLIL--GVFGINKLRTAT 356
|
330 340 350
....*....|....*....|....*....|.
gi 479837353 363 KAELgiSDGLLRVSVGLEDTDDLLEDVEVAL 393
Cdd:PRK09028 357 NWDF--SKPLIRLHIGLEDVDDLIADLEAGF 385
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
12-390 |
1.36e-39 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 145.62 E-value: 1.36e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 12 ATELVHAG--------SLRSGFAEMSEALFLTqgfLYPTAEAAEARFKGEdpgFIYSRYANPTTDMFEKRMCALEGAEDA 83
Cdd:PRK08114 7 DTQLVNAGrskkytqgSVNSVIQRASSLVFDS---VEAKKHATRNRANGE---LFYGRRGTLTHFSLQEAMCELEGGAGC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 84 RATASGMAAVAAAILCQVQAGDHVISARAVFGSCRYIVETVLPRYGVEVSIID---GSDVAnwkAAVRPNTKVMFLESPS 160
Cdd:PRK08114 81 ALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDpliGADIA---KLIQPNTKVVFLESPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 161 NPTLEIIDI----AAVAQIANEagAKLIVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRC-LGGVVLSDREWIETTL 235
Cdd:PRK08114 158 SITMEVHDVpaivAAVRSVNPD--AVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAmIGTAVANARCWEQLRE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 236 QDYFrhTGPGLSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADHPQADIIAKQMTGGSTLIAL 315
Cdd:PRK08114 236 NSYL--MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 316 ELEG--GKEAAFKFENALQIFSITNNLGDTKSLITHpattthkNLSNEAKA-----ELGISDGLLRVSVGLEDTDDLLED 388
Cdd:PRK08114 314 VLKKklTDEQLANYLDNFSLFSMAYSWGGFESLILA-------NQPEEIAAirpagEVDFTGTLIRLHIGLEDVDDLIAD 386
|
..
gi 479837353 389 VE 390
Cdd:PRK08114 387 LA 388
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
70-224 |
2.60e-07 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 50.07 E-value: 2.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 70 FEKRMCAL--EGAEDARATASGMAAVAAAILCQVQAGDHVISARAVFGScRYIVETVLPryGVEVSII----------DG 137
Cdd:cd01494 5 LEEKLARLlqPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGS-RYWVAAELA--GAKPVPVpvddagygglDV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 138 SDVANWKAAvrPNTKVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFATP----LFQKPLELGAHIVVYSATKHI 213
Cdd:cd01494 82 AILEELKAK--PNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGaspaPGVLIPEGGADVVTFSLHKNL 159
|
170
....*....|.
gi 479837353 214 DGQGrclGGVV 224
Cdd:cd01494 160 GGEG---GGVV 167
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
101-189 |
9.44e-07 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 50.32 E-value: 9.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 101 VQAGDHVISaravfgscryivetVLPRY----------GVEVSIIDGSDVANW-------KAAVRPNTKVMFLESPSNPT 163
Cdd:PRK07324 101 VEPGDHVIS--------------VYPTYqqlydipeslGAEVDYWQLKEENGWlpdldelRRLVRPNTKLICINNANNPT 166
|
90 100
....*....|....*....|....*....
gi 479837353 164 LEIID---IAAVAQIANEAGAKLIVDNVF 189
Cdd:PRK07324 167 GALMDrayLEEIVEIARSVDAYVLSDEVY 195
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
101-292 |
9.58e-06 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 47.34 E-value: 9.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 101 VQAGDHVISARAVFGSCRYIVEtvlpRYGVEVSII-------DGSDVANWKAAVRPNTKVMFLESPSNPT-----LEiiD 168
Cdd:cd00609 80 LNPGDEVLVPDPTYPGYEAAAR----LAGAEVVPVpldeeggFLLDLELLEAAKTPKTKLLYLNNPNNPTgavlsEE--E 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 169 IAAVAQIANEAGAKLIVDNVFA-------TPLFQKPLELGAH-IVVYSATKhidgqgrCLG------GVVLSDREWIETT 234
Cdd:cd00609 154 LEELAELAKKHGILIISDEAYAelvydgePPPALALLDAYERvIVLRSFSK-------TFGlpglriGYLIAPPEELLER 226
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 479837353 235 LQDYFRHTGPGLSPFNAWIMLKGLETLSVRVRQQTQS----AAAIADFLAGKPGVKRVIYPG 292
Cdd:cd00609 227 LKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEELRERyrrrRDALLEALKELGPLVVVKPSG 288
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
98-186 |
8.83e-05 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 44.36 E-value: 8.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 98 LCQVQAGDHVISARAVFGScryiveTVLP------RYGVEVSII----DGS-DVANWKAAVRPNTKVMFLESPSNPTLEI 166
Cdd:COG0520 97 LGRLKPGDEILITEMEHHS------NIVPwqelaeRTGAEVRVIpldeDGElDLEALEALLTPRTKLVAVTHVSNVTGTV 170
|
90 100
....*....|....*....|
gi 479837353 167 IDIAAVAQIANEAGAKLIVD 186
Cdd:COG0520 171 NPVKEIAALAHAHGALVLVD 190
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
139-211 |
9.47e-05 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 44.35 E-value: 9.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 139 DVANWKAAVRPNTKVMFLESPSNPT-----LEiiDIAAVAQIANEAGAKLIVDNVF---------ATPLFQKPlELGAH- 203
Cdd:COG0436 152 DPEALEAAITPRTKAIVLNSPNNPTgavysRE--ELEALAELAREHDLLVISDEIYeelvydgaeHVSILSLP-GLKDRt 228
|
....*...
gi 479837353 204 IVVYSATK 211
Cdd:COG0436 229 IVINSFSK 236
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
65-296 |
3.92e-04 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 42.36 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 65 PTTDMFEKRMCALEGAEDARATASG-------MaavaaaILCQVQAGDHVIS----------------ARAVFgscryiV 121
Cdd:COG0399 30 PEVKEFEEEFAAYLGVKHAVAVSSGtaalhlaL------RALGIGPGDEVITpaftfvatanailyvgATPVF------V 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 122 EtVLPRYGVevsiIDGSDVAnwkAAVRPNTKVmflespsnptleII---------DIAAVAQIANEAGAKLIVDNVFAtp 192
Cdd:COG0399 98 D-IDPDTYN----IDPEALE---AAITPRTKA------------IIpvhlygqpaDMDAIMAIAKKHGLKVIEDAAQA-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 193 lfqkpleLGA-----------HIVVYS--ATKHI---DGqgrclGGVVLSDREWIET--TLQDY-------FRHTGPG-- 245
Cdd:COG0399 156 -------LGAtykgkkvgtfgDAGCFSfyPTKNLttgEG-----GAVVTNDEELAERarSLRNHgrdrdakYEHVELGyn 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 479837353 246 --LSPFNAWIMLKGLETLSVRVRQQTQSAAAIADFLAGKPGVKRVIYPGRADH 296
Cdd:COG0399 224 yrMDELQAAIGLAQLKRLDEFIARRRAIAARYREALADLPGLTLPKVPPGAEH 276
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
97-190 |
5.60e-04 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 41.52 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 97 ILCQVQAGDHVISARAVFGScrYIveTVLPRYGVEVSIIDGSDVANWK-------AAVRPNTKVMFLESPSNPT-----L 164
Cdd:pfam00155 80 IFLLANPGDAILVPAPTYAS--YI--RIARLAGGEVVRYPLYDSNDFHldfdaleAALKEKPKVVLHTSPHNPTgtvatL 155
|
90 100
....*....|....*....|....*.
gi 479837353 165 EiiDIAAVAQIANEAGAKLIVDNVFA 190
Cdd:pfam00155 156 E--ELEKLLDLAKEHNILLLVDEAYA 179
|
|
| glyA |
PRK00011 |
serine hydroxymethyltransferase; Reviewed |
166-236 |
1.33e-03 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 234571 Cd Length: 416 Bit Score: 40.44 E-value: 1.33e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 479837353 166 IIDIAAVAQIANEAGAKLIVD--NVF---ATPLFQKPLElGAHIVVYSATKHIDGqGRclGGVVLSDREWIETTLQ 236
Cdd:PRK00011 179 PIDFKRFREIADEVGAYLMVDmaHIAglvAAGVHPSPVP-HADVVTTTTHKTLRG-PR--GGLILTNDEELAKKIN 250
|
|
| PRK09275 |
PRK09275 |
bifunctional aspartate transaminase/aspartate 4-decarboxylase; |
119-212 |
2.09e-03 |
|
bifunctional aspartate transaminase/aspartate 4-decarboxylase;
Pssm-ID: 236444 Cd Length: 527 Bit Score: 40.23 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 119 YIVETVLPRYGVEVSIIDGSDVANW---KAAVR----PNTKVMFLESPSNPTLEIID---IAAVAQIANEAGAKLIV--D 186
Cdd:PRK09275 203 YLEIPELPRYDLEVVHINADEENEWqypDSELEklrdPSIKALFLVNPSNPPSVAMSdesLEKIADIVNEKRPDLMIitD 282
|
90 100 110
....*....|....*....|....*....|
gi 479837353 187 NVFAT--PLFQKPLELGAH--IVVYSATKH 212
Cdd:PRK09275 283 DVYGTfvDDFRSLFAVLPYntILVYSFSKY 312
|
|
| PRK03317 |
PRK03317 |
histidinol-phosphate aminotransferase; Provisional |
139-190 |
5.74e-03 |
|
histidinol-phosphate aminotransferase; Provisional
Pssm-ID: 235115 Cd Length: 368 Bit Score: 38.69 E-value: 5.74e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 479837353 139 DVANWKAAV---RPNtkVMFLESPSNPTLEIIDIAAVAQIANEAGAKLIVDNVFA 190
Cdd:PRK03317 148 DVDAAVAAIaehRPD--VVFLTSPNNPTGTALPLDDVEAILDAAPGIVVVDEAYA 200
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
139-189 |
5.92e-03 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 38.48 E-value: 5.92e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 479837353 139 DVANWKAAVRPNTKVMFLESPSNPTLEII---DIAAVAQIANEAGAKLIVDNVF 189
Cdd:PRK07777 148 DLDALRAAVTPRTRALIVNSPHNPTGTVLtaaELAAIAELAVEHDLLVITDEVY 201
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
107-211 |
9.99e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 37.98 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 479837353 107 VISARAVFGSCRYIVETVLPRYGVEVSIID-----GSDVANWKAAVRPNTKVMFLESPSnpTLEII--DIAAVAQIANEA 179
Cdd:cd00613 111 VLVPDSAHPTNPAVARTRGEPLGIEVVEVPsdeggTVDLEALKEEVSEEVAALMVQYPN--TLGVFedLIKEIADIAHSA 188
|
90 100 110
....*....|....*....|....*....|....
gi 479837353 180 GAKLIV--DNVFATpLFQKPLELGAHIVVYSATK 211
Cdd:cd00613 189 GALVYVdgDNLNLT-GLKPPGEYGADIVVGNLQK 221
|
|
| |
