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Conserved domains on  [gi|480339774|gb|ENX59965|]
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hypothetical protein F885_02157 [Acinetobacter higginsii]

Protein Classification

flavin-containing monooxygenase( domain architecture ID 11449697)

flavin-containing monooxygenase (FMO) catalyses the flavin-dependent oxidation of ketones and cyclic ketones to esters and lactones, by using molecular oxygen and NAD(P)H.

CATH:  3.50.50.60
Gene Ontology:  GO:0016709|GO:0004497|GO:0050660
PubMed:  20015679|33588053

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 8-450 1.50e-168

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 482.06  E-value: 1.50e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   8 AIQKTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGGTWRENQYPGAACDVQSHMYSLSFAPKTDWSKRYAEADE 87
Cdd:COG2072    3 ATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGDE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  88 IFDYIQNITEQYRLRDYCKFNHEVTNAEFDENRNVWTLDFKDQTTLEAQFVIFASGPLHVPQIPHIKGIEKFKGKVFHSS 167
Cdd:COG2072   82 ILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHSA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 168 QWDHNYDLSGKAVVSIGTGGSAIQYIPEIAAEVKQLYVFQRTAAWVIPRDerkysqlskrlfkasNIYRQIHRTRLYWTN 247
Cdd:COG2072  162 DWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---------------NYDPERGRPANYLGL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 248 ESRvVPIVQPQIMkygqKLAEAFIRYQVKDKALaKKLTPDFVMGCKRILISNKYFPTFNRKNVELVTDAIQEITENGIIT 327
Cdd:COG2072  227 EAP-PALNRRDAR----AWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGVVF 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 328 KDGKERQIDCLIYGTGFITDPRiYLKHFNCVGRNGielkqawKDGAESYYGVSTKNFPNLFqLLGPNTILGHNSVIFMIE 407
Cdd:COG2072  301 ADGTEHEVDVIVWATGFRADLP-WLAPLDVRGRDG-------RSGPRAYLGVVVPGFPNLF-FLGPNSPSGHSSLTLGAE 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 480339774 408 SQVNYILQLIQTVDKTDTQAVEIKHEVQDQFNQRVQDQLKGTV 450
Cdd:COG2072  372 RQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 8-450 1.50e-168

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 482.06  E-value: 1.50e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   8 AIQKTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGGTWRENQYPGAACDVQSHMYSLSFAPKTDWSKRYAEADE 87
Cdd:COG2072    3 ATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGDE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  88 IFDYIQNITEQYRLRDYCKFNHEVTNAEFDENRNVWTLDFKDQTTLEAQFVIFASGPLHVPQIPHIKGIEKFKGKVFHSS 167
Cdd:COG2072   82 ILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHSA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 168 QWDHNYDLSGKAVVSIGTGGSAIQYIPEIAAEVKQLYVFQRTAAWVIPRDerkysqlskrlfkasNIYRQIHRTRLYWTN 247
Cdd:COG2072  162 DWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---------------NYDPERGRPANYLGL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 248 ESRvVPIVQPQIMkygqKLAEAFIRYQVKDKALaKKLTPDFVMGCKRILISNKYFPTFNRKNVELVTDAIQEITENGIIT 327
Cdd:COG2072  227 EAP-PALNRRDAR----AWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGVVF 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 328 KDGKERQIDCLIYGTGFITDPRiYLKHFNCVGRNGielkqawKDGAESYYGVSTKNFPNLFqLLGPNTILGHNSVIFMIE 407
Cdd:COG2072  301 ADGTEHEVDVIVWATGFRADLP-WLAPLDVRGRDG-------RSGPRAYLGVVVPGFPNLF-FLGPNSPSGHSSLTLGAE 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 480339774 408 SQVNYILQLIQTVDKTDTQAVEIKHEVQDQFNQRVQDQLKGTV 450
Cdd:COG2072  372 RQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 11-344 2.53e-20

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 94.07  E-value: 2.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   11 KTKVAIIGAGFGGLAmAIRLLQSQINDFVILEKTNDVGGTWR--ENQYPGAACDVQS-------HMYSLSFAPKTDWSKR 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLA-SIKCCLEEGLEPTCFERSDDIGGLWRftENVEEGRASIYKSvitntskEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   82 YAEADEIFDYIQNITEQYRLRDYCKFNHEVTNA----EFDENRNVWTLDFKDQTTLEAQF--VIFASGPLHVPQIP--HI 153
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVkkrpDFSTSGQWEVVTEHEGKQESAVFdaVMVCTGHHTNPHLPleSF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  154 KGIEKFKGKVFHSSQWDHNYDLSGKAVVSIGTGGSAIQYIPEIAAEVKQLYVFQRTAAWVIPR---DERKYSQLSKRLFK 230
Cdd:pfam00743 160 PGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRvsdHGYPWDMLFSTRFT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  231 asNIYRQIHRTRLY-WTNESrvvpivqpqimKYGQKLAEAFIRYQVKDKALAKKLT-PDFVMGCkriLISNKYFptfnrk 308
Cdd:pfam00743 240 --SFLRNILPTSISnWLMEK-----------QMNRRFNHENYGLKPKNRALSKEPVvNDDLPNR---ILCGAVK------ 297

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 480339774  309 nvelVTDAIQEITENGIITKDG-KERQIDCLIYGTGF 344
Cdd:pfam00743 298 ----VKPNVKEFTETSAIFEDGtVEEDIDVVIFATGY 330
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 5-208 7.67e-14

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 73.36  E-value: 7.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   5 TKNAIQKTKVAIIGAGFGGLAMAiRLLQSQINDFVILEKTNDVGGTWreNQYPGAACD----------VQSHMYS----- 69
Cdd:PLN02172   4 AQNPINSQHVAVIGAGAAGLVAA-RELRREGHTVVVFEREKQVGGLW--VYTPKSESDplsldptrsiVHSSVYEslrtn 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  70 ----------LSFAPKTDW----SKRYAEADEIFDYIQNITEQYRLRDYCKFNHEVTNAE-FDENRNVWT---LDFKDQT 131
Cdd:PLN02172  81 lprecmgyrdFPFVPRFDDesrdSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEpVDGKWRVQSknsGGFSKDE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 132 TLEAqfVIFASGPLHVPQIPHIKGIEKFKGKVFHSsqwdHNYDLSG----KAVVSIGTGGSAIQYIPEIAAEVKQLYVFQ 207
Cdd:PLN02172 161 IFDA--VVVCNGHYTEPNVAHIPGIKSWPGKQIHS----HNYRVPDpfknEVVVVIGNFASGADISRDIAKVAKEVHIAS 234


                 .
gi 480339774 208 R 208
Cdd:PLN02172 235 R 235
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 14-49 1.07e-03

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 41.49  E-value: 1.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 480339774   14 VAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGG 49
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGI-PVTVVEQRDKPGG 35
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 8-450 1.50e-168

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 482.06  E-value: 1.50e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   8 AIQKTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGGTWRENQYPGAACDVQSHMYSLSFAPKTDWSKRYAEADE 87
Cdd:COG2072    3 ATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVGGTWRDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTGDE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  88 IFDYIQNITEQYRLRDYCKFNHEVTNAEFDENRNVWTLDFKDQTTLEAQFVIFASGPLHVPQIPHIKGIEKFKGKVFHSS 167
Cdd:COG2072   82 ILAYLEAYADKFGLRRPIRFGTEVTSARWDEADGRWTVTTDDGETLTARFVVVATGPLSRPKIPDIPGLEDFAGEQLHSA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 168 QWDHNYDLSGKAVVSIGTGGSAIQYIPEIAAEVKQLYVFQRTAAWVIPRDerkysqlskrlfkasNIYRQIHRTRLYWTN 247
Cdd:COG2072  162 DWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---------------NYDPERGRPANYLGL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 248 ESRvVPIVQPQIMkygqKLAEAFIRYQVKDKALaKKLTPDFVMGCKRILISNKYFPTFNRKNVELVTDAIQEITENGIIT 327
Cdd:COG2072  227 EAP-PALNRRDAR----AWLRRLLRAQVKDPEL-GLLTPDYPPGCKRPLLSTDYYEALRRGNVELVTGGIERITEDGVVF 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 328 KDGKERQIDCLIYGTGFITDPRiYLKHFNCVGRNGielkqawKDGAESYYGVSTKNFPNLFqLLGPNTILGHNSVIFMIE 407
Cdd:COG2072  301 ADGTEHEVDVIVWATGFRADLP-WLAPLDVRGRDG-------RSGPRAYLGVVVPGFPNLF-FLGPNSPSGHSSLTLGAE 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 480339774 408 SQVNYILQLIQTVDKTDTQAVEIKHEVQDQFNQRVQDQLKGTV 450
Cdd:COG2072  372 RQARYIARLIAHMRRRGAAAIEVRPEAEDAFNARLQRRAARTV 414
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 11-344 2.53e-20

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 94.07  E-value: 2.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   11 KTKVAIIGAGFGGLAmAIRLLQSQINDFVILEKTNDVGGTWR--ENQYPGAACDVQS-------HMYSLSFAPKTDWSKR 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLA-SIKCCLEEGLEPTCFERSDDIGGLWRftENVEEGRASIYKSvitntskEMSCFSDFPFPEDYPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   82 YAEADEIFDYIQNITEQYRLRDYCKFNHEVTNA----EFDENRNVWTLDFKDQTTLEAQF--VIFASGPLHVPQIP--HI 153
Cdd:pfam00743  80 FMHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVkkrpDFSTSGQWEVVTEHEGKQESAVFdaVMVCTGHHTNPHLPleSF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  154 KGIEKFKGKVFHSSQWDHNYDLSGKAVVSIGTGGSAIQYIPEIAAEVKQLYVFQRTAAWVIPR---DERKYSQLSKRLFK 230
Cdd:pfam00743 160 PGIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRvsdHGYPWDMLFSTRFT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  231 asNIYRQIHRTRLY-WTNESrvvpivqpqimKYGQKLAEAFIRYQVKDKALAKKLT-PDFVMGCkriLISNKYFptfnrk 308
Cdd:pfam00743 240 --SFLRNILPTSISnWLMEK-----------QMNRRFNHENYGLKPKNRALSKEPVvNDDLPNR---ILCGAVK------ 297

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 480339774  309 nvelVTDAIQEITENGIITKDG-KERQIDCLIYGTGF 344
Cdd:pfam00743 298 ----VKPNVKEFTETSAIFEDGtVEEDIDVVIFATGY 330
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 5-208 7.67e-14

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 73.36  E-value: 7.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   5 TKNAIQKTKVAIIGAGFGGLAMAiRLLQSQINDFVILEKTNDVGGTWreNQYPGAACD----------VQSHMYS----- 69
Cdd:PLN02172   4 AQNPINSQHVAVIGAGAAGLVAA-RELRREGHTVVVFEREKQVGGLW--VYTPKSESDplsldptrsiVHSSVYEslrtn 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  70 ----------LSFAPKTDW----SKRYAEADEIFDYIQNITEQYRLRDYCKFNHEVTNAE-FDENRNVWT---LDFKDQT 131
Cdd:PLN02172  81 lprecmgyrdFPFVPRFDDesrdSRRYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEpVDGKWRVQSknsGGFSKDE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 132 TLEAqfVIFASGPLHVPQIPHIKGIEKFKGKVFHSsqwdHNYDLSG----KAVVSIGTGGSAIQYIPEIAAEVKQLYVFQ 207
Cdd:PLN02172 161 IFDA--VVVCNGHYTEPNVAHIPGIKSWPGKQIHS----HNYRVPDpfknEVVVVIGNFASGADISRDIAKVAKEVHIAS 234


                 .
gi 480339774 208 R 208
Cdd:PLN02172 235 R 235
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
23-222 2.54e-12

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 67.63  E-value: 2.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   23 GLAMAIRLLQSQINDFVILEKTNdVGGTWREnqYPgaacdvqSHM--YSLSF-----------------APKTDWSKRYA 83
Cdd:pfam13738   3 GIGCAIALKKAGLEDYLILEKGN-IGNSFYR--YP-------THMtfFSPSFtsngfgipdlnaispgtSPAFTFNREHP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   84 EADEIFDYIQNITEQYRLRdyCKFNHEVTNAEFDENrnvwtlDFKDQT---TLEAQFVIFASGPLHVPQIPHikgiekFK 160
Cdd:pfam13738  73 SGNEYAEYLRRVADHFELP--INLFEEVTSVKKEDD------GFVVTTskgTYQARYVIIATGEFDFPNKLG------VP 138

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 480339774  161 GKVFHSSQWDHNYDLSGKAVVSIGTGGSAIQYIPEIAAEVKQLYVFQRTAAWVIPRDERKYS 222
Cdd:pfam13738 139 ELPKHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEWEDRDSDPSYS 200
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
12-234 4.72e-11

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 63.60  E-value: 4.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  12 TKVAIIGAGFGGLAMAI----RLLqsqinDFVILEKtNDVGG-----TWRENqYPGAAcdvqshmyslsfapktdwskry 82
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIyaarAGL-----KTLVIEG-GEPGGqlattKEIEN-YPGFP---------------------- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  83 aeaDEI--FDYIQNITEQYRlrdycKFN-----HEVTNAEFDENrnVWTLDFKDQTTLEAQFVIFASGplHVPQIPHIKG 155
Cdd:COG0492   52 ---EGIsgPELAERLREQAE-----RFGaeillEEVTSVDKDDG--PFRVTTDDGTEYEAKAVIIATG--AGPRKLGLPG 119

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774 156 IEKFKGK-VFHSSQWDHNYdLSGKAVVSIGTGGSAIQ---YIPEIAAEVKqlyvfqrtaaWVIPRDE-RKYSQLSKRLFK 230
Cdd:COG0492  120 EEEFEGRgVSYCATCDGFF-FRGKDVVVVGGGDSALEealYLTKFASKVT----------LIHRRDElRASKILVERLRA 188


                 ....
gi 480339774 231 ASNI 234
Cdd:COG0492  189 NPKI 192
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
16-66 6.48e-08

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 49.45  E-value: 6.48e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 480339774   16 IIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGGTWRENQYPGAACDVQSH 66
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF-RVLVLEKRDRLGGNAYSYRVPGYVFDYGAH 50
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 10-143 2.55e-06

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 49.55  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  10 QKTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGGTWR-----------------ENQYPGAACDVQSHMYSLSF 72
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGI-RVTVVERAPPPRPDGRgialsprslellrrlglWDRLLARGAPIRGIRVRDGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  73 APKTDWSKRYAEADEIFDYI--QNITEQYrLRDYCK-------FNHEVTNAEFDENRnvWTLDFKDQTTLEAQFVIFASG 143
Cdd:COG0654   81 DGRVLARFDAAETGLPAGLVvpRADLERA-LLEAARalgvelrFGTEVTGLEQDADG--VTVTLADGRTLRADLVVGADG 157
PLN02676 PLN02676
polyamine oxidase
 14-58 4.08e-06

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 49.33  E-value: 4.08e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 480339774  14 VAIIGAGFGGLAMAIRLLQSQINDFVILEKTNDVGGTWRENQYPG 58
Cdd:PLN02676  29 VIIVGAGMSGISAAKTLSEAGIEDILILEATDRIGGRMRKANFAG 73
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 100-189 1.65e-05

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 46.81  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  100 RLRDYCKFNHEVTNAEFDE--NRNVWTLDFKDQ----TTLEAQFVIFASGPlhVPQIPhikgiEKFKGK--VFHSSQW-- 169
Cdd:pfam13434 107 HLPNRLRFGQEVESVEPDAerGEPLLRVRVRDAdgeeTTFLARNLVLGTGG--EPYIP-----ECARGGerVFHSSEYle 179

                          90       100
                  ....*....|....*....|
gi 480339774  170 DHNYDLSGKAVVSIGTGGSA 189
Cdd:pfam13434 180 RIDRLAAKKRIAVVGSGQSA 199
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 11-57 2.86e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 46.36  E-value: 2.86e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 480339774  11 KTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGG---TWRENQYP 57
Cdd:COG1232    1 MKRVAVIGGGIAGLTAAYRLAKAGH-EVTVLEASDRVGGlirTVEVDGFR 49
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 10-70 6.24e-05

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 45.61  E-value: 6.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 480339774  10 QKTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGG---TWREnqyPGAACDVQSHMYSL 70
Cdd:COG1233    2 MMYDVVVIGAGIGGLAAAALLARAGY-RVTVLEKNDTPGGrarTFER---PGFRFDVGPSVLTM 61
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 12-186 1.17e-04

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 44.23  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   12 TKVAIIGAGFGGLAMAIRLLQSQINDFVIlektnDVGGTWrenqyPGAACDVQSHMYSLSFAPKT--DWSKRYAEADEIF 89
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLI-----EDEGTC-----PYGGCVLSKALLGAAEAPEIasLWADLYKRKEEVV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   90 DYIQNITEQYrlrdyckFNHEVTNAEFDENR-NVWTLDFKDQTTLEAQFVIFASGPlhVPQIPHIKGIEKFKGKVFHSsq 168
Cdd:pfam07992  71 KKLNNGIEVL-------LGTEVVSIDPGAKKvVLEELVDGDGETITYDRLVIATGA--RPRLPPIPGVELNVGFLVRT-- 139

                         170       180
                  ....*....|....*....|..
gi 480339774  169 WDH----NYDLSGKAVVSIGTG 186
Cdd:pfam07992 140 LDSaealRLKLLPKRVVVVGGG 161
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
10-190 4.47e-04

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 42.63  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  10 QKTKVAIIGAGFGGLAMAIRLLQSQINDF--VILEKTNDVG-----GT--------------------------WRENQY 56
Cdd:COG4529    4 ARKRIAIIGGGASGTALAIHLLRRAPEPLriTLFEPRPELGrgvaySTdspehllnvpagrmsafpddpdhflrWLRENG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774  57 PGAACDVQSHmyslSFAPktdwskRYaeadeIF-DYIQNITEQY--RLRDYCKFNH---EVTNAEFDENRnvWTLDFKDQ 130
Cdd:COG4529   84 ARAAPAIDPD----AFVP------RR-----LFgEYLRERLAEAlaRAPAGVRLRHiraEVVDLERDDGG--YRVTLADG 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 480339774 131 TTLEAQFVIFASGplHVPqiPHIKGIEKFKGKVFHSSQWDhNYDLS----GKAVVSIGTGGSAI 190
Cdd:COG4529  147 ETLRADAVVLATG--HPP--PAPPPGLAAGSPRYIADPWP-PGALArippDARVLIIGTGLTAI 205
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 105-143 4.54e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 42.91  E-value: 4.54e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 480339774 105 CKFNHEVTNAEFDENRnvWTLDFKDQTTLEAQFVIFASG 143
Cdd:PRK01747 424 IHFGHEVARLEREDDG--WQLDFAGGTLASAPVVVLANG 460
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
15-143 8.48e-04

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 39.95  E-value: 8.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   15 AIIGAGFGGLAMAIRLLQSQIN---DFVILEKTND-VGGTWRENQYPG-----AACDVqsHMY---SLSFApktdwskRY 82
Cdd:pfam13454   1 AIVGGGPSGLALLERLLARAPKrplEITLFDPSPPgAGGVYRTDQSPEhllnvPASRM--SLFpddPPHFL-------EW 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 480339774   83 AEADEIFDYIQNITEQ----------Y---RLRDYCK----------FNHEVTNAEFDENRNVWTLDfkDQTTLEAQFVI 139
Cdd:pfam13454  72 LRARGALDEAPGLDPDdfppralygrYlrdRFEEALArapagvtvrvHRARVTDLRPRGDGYRVLLA--DGRTLAADAVV 149


                  ....
gi 480339774  140 FASG 143
Cdd:pfam13454 150 LATG 153
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 14-49 1.07e-03

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 41.49  E-value: 1.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 480339774   14 VAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGG 49
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGI-PVTVVEQRDKPGG 35
PRK07208 PRK07208
hypothetical protein; Provisional
 10-58 1.13e-03

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 41.41  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 480339774  10 QKTKVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGGTWRENQYPG 58
Cdd:PRK07208   3 NKKSVVIIGAGPAGLTAAYELLKRGY-PVTVLEADPVVGGISRTVTYKG 50
PRK07233 PRK07233
hypothetical protein; Provisional
 13-57 1.36e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 41.03  E-value: 1.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 480339774  13 KVAIIGAGFGGLAMAIRLLQSQInDFVILEKTNDVGG---TWRENQYP 57
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGH-EVTVFEADDQLGGlaaSFEFGGLP 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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