|
Name |
Accession |
Description |
Interval |
E-value |
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
109-576 |
1.23e-130 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 391.26 E-value: 1.23e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 109 KKIHEKDSQMNaitnhegDCLGSILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIINnPKVMKLLHP--------- 179
Cdd:COG5809 4 SKMELQLRKSE-------QRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLG-TNILDFLHPddekelrei 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 180 --YRPNRNDFRDWEMDITCKNGEIKTIMWSNIlhsiPTLGWNVG-----AIGIDITRRKRMEEKLKQTSNELELIFKAIP 252
Cdd:COG5809 76 lkLLKEGESRDELEFELRHKNGKRLEFSSKLS----PIFDQNGDiegmlAISRDITERKRMEEALRESEEKFRLIFNHSP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 253 DLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEILPVPIIKQFEKAINQIKTSSAPVLIDYSLQL-DDEIYYFEAR 331
Cdd:COG5809 152 DGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGGIAQGEVRFWTkDGRWRLLEAS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 332 LLPLFED----KIMIIVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD-KECLSLIL 406
Cdd:COG5809 232 GAPIKKNgevdGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEqKTYLDIML 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 407 SEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNS 486
Cdd:COG5809 312 SELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 487 IEAIQNGQEIIISVKKHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGKG 566
Cdd:COG5809 392 IEAMPEGGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKG 471
|
490
....*....|
gi 500438795 567 TTVTLFFPIY 576
Cdd:COG5809 472 TTFSITLPIK 481
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
119-575 |
1.38e-124 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 375.99 E-value: 1.38e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 119 NAITNHEGdcLGSILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIINNP------KVMKLLHPYRPNR----NDFR 188
Cdd:COG5805 28 MAIEITEE--LETILENLPDAIIAVNREGKVIYINPAMEKLLGYTSEEIIGKTifdfleKEYHYRVKTRIERlqkgYDVV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 189 DWEMdITCKNGEIKTIMWSNILHSIPTLGWNVGAIgIDITRRKRMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCK 268
Cdd:COG5805 106 MIEQ-IYCKDGELIYVEVKLFPIYNQNGQAAILAL-RDITKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFIN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 269 VNSVSKFYVPIEEFIGKKFQEILPVPIIKQFEKAINQIKTSSAPVLIDYS-LQLDDEIYYFEARLLPLFEDK-----IMI 342
Cdd:COG5805 184 ESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREiITKDGRIRYFEAVIVPLIDTDgsvkgILV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 343 IVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKDKECLSLILSEISSIEKVIQEFLSI 422
Cdd:COG5805 264 ILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLAL 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 423 AKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKK 502
Cdd:COG5805 344 AKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEE 423
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500438795 503 HNSTeIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG5805 424 EDNS-VIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
236-580 |
1.08e-81 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 260.55 E-value: 1.08e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 236 KLKQTSNELELIFKAIPDLYFLSELDGTIKDckVNSVSK--FYVPIEEFIGKKFQEILPVPiiKQFEKAINQIKTSSAPV 313
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITY--VNPAAErlLGLSAEELLGRPLAELFPED--SPLRELLERALAEGQPV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 314 lIDYSLQL---DDEIYYFEARLLPLFEDK----IMIIVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKG 386
Cdd:COG3852 77 -TEREVTLrrkDGEERPVDVSVSPLRDAEgeggVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 387 FMQLLQQEVG--KDKECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAImKNIRITLNVDAE 464
Cdd:COG3852 156 AAQLLERELPddELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 465 NLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISV---------KKHNSTEIKISILDKGIGIPSERIKRLGEPFYSTK 535
Cdd:COG3852 235 LPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrverqvtlgGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTK 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 500438795 536 EKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPIYNGDS 580
Cdd:COG3852 315 EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
221-576 |
1.97e-79 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 254.71 E-value: 1.97e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 221 GAIGIDITRRKRMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEilpVPIIKQFE 300
Cdd:COG5807 6 ATDFYHIEEKNQEFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVE---EKCILKDE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 301 KAINQIKTSSAPVLIDYSLQLDDEIYYfearllPLFEDKIMI-----IVRDITERTIMTELLKKSDTINAVGQLAAGVAH 375
Cdd:COG5807 83 QLYNKEAFDRIEISYLTKNGEFDEIIY------PIYYKDGVIlglitVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 376 KVRNPLTVIKGFMQLLQQEVGKD--KECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMK 453
Cdd:COG5807 157 EIRNPLTSIKGFLQLLQESREDSerEEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAILK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 454 NIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNsTEIKISILDKGIGIPSERIKRLGEPFYS 533
Cdd:COG5807 237 NISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEG-DFVVISVKDEGIGIPEEVLEKIGEPFFT 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 500438795 534 TKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPIY 576
Cdd:COG5807 316 TKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPLY 358
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
231-575 |
7.42e-73 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 239.48 E-value: 7.42e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 231 KRMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEILPvpiIKQFEKAINQIKTSS 310
Cdd:COG5000 79 KEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLP---ELDLAELLREALERG 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 311 APVLIDYSLqldDEIYYFEARLLPLFEDKIMIIVRDITErtimtelLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQL 390
Cdd:COG5000 156 WQEEIELTR---DGRRTLLVRASPLRDDGYVIVFDDITE-------LLRAERLAAWGELARRIAHEIKNPLTPIQLSAER 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 391 LQQEVGKD--------KECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVD 462
Cdd:COG5000 226 LRRKLADKleedredlERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLD 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 463 AENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVG 542
Cdd:COG5000 306 PDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDG-RVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLG 384
|
330 340 350
....*....|....*....|....*....|...
gi 500438795 543 LMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG5000 385 LAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
313-576 |
6.50e-68 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 225.90 E-value: 6.50e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 313 VLIDYSLQLDDEIYYFearLLPLFedkIMIIVRDITERTIMTELLK----KSDTINAVGQLAAGVAHKVRNPLTVIKGFM 388
Cdd:COG5806 150 FIADISELLDFILYFI---IIQLL---AMLIAVYLIENLIENILLRkelqRAEKLEVVSELAASIAHEVRNPLTVVRGFI 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 389 QLLQQEVG---KDKECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDaEN 465
Cdd:COG5806 224 QLLQEPELsdeKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELE-PG 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 466 LLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNSTeIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMM 545
Cdd:COG5806 303 LYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNK-VIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMV 381
|
250 260 270
....*....|....*....|....*....|.
gi 500438795 546 SYRIIESHGGKISIKSQVGKGTTVTLFFPIY 576
Cdd:COG5806 382 SYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
342-580 |
1.02e-61 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 214.83 E-value: 1.02e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 342 IIVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD--KECLSLILSEISSIEKVIQEF 419
Cdd:PRK11360 366 VIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPpsQEYLSVVLREVDRLNKVIDQL 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 420 LSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIIS 499
Cdd:PRK11360 446 LEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIR 525
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 500 VKKHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPIYNGD 579
Cdd:PRK11360 526 TWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQG 605
|
.
gi 500438795 580 S 580
Cdd:PRK11360 606 N 606
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
313-575 |
6.33e-59 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 200.79 E-value: 6.33e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 313 VLIDYSLQLDDEIYYFEARLLPLFEDKIMIIVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQ 392
Cdd:COG4191 89 LLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLR 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 393 QEVGKD------KECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENL 466
Cdd:COG4191 169 RRLEDEpdpeelREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLP 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 467 LVECCEIQLKHVFYSILQNSIEAIQNGQ--EIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTKE--KGTGVG 542
Cdd:COG4191 249 PVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGD-YVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLG 327
|
250 260 270
....*....|....*....|....*....|...
gi 500438795 543 LMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG4191 328 LSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
365-575 |
1.33e-53 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 185.50 E-value: 1.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 365 AVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD-KECLSLILSEISSIEKVIQEFLSIAKPNAA----VFEPKNLCTIL 439
Cdd:COG0642 109 AKSRFLANVSHELRTPLTAIRGYLELLLEELDEEqREYLETILRSADRLLRLINDLLDLSRLEAGklelEPEPVDLAELL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 440 DNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNSTeIKISILDKGIGI 519
Cdd:COG0642 189 EEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDR-VRISVEDTGPGI 267
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 520 PSERIKRLGEPFYSTKE----KGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG0642 268 PPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
240-575 |
4.02e-51 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 182.26 E-value: 4.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 240 TSNELELIFKAIPDLYFLSELDGTIKDCKVNSVSK-FYVPIEEFIGKKFQEILPVPIIK----QFEKAINQIKTSSAPVL 314
Cdd:COG5808 110 TSTISAPIMDKELTNFLLASIRMDYIRALINILDPdKYIEIVDQNGQSVFTSGHREESKsvsnKLDKVPWEVEVYPNPVT 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 315 IDY---SLQLDDEIYYFEARLLPLFEDKIMIIVRDITERTIMTELLKKsdtINAVGQLAAGVAHKVRNPLTVIKGFMQLL 391
Cdd:COG5808 190 NDElgqALAIRKLIILVLISIIFLLLQYNLLKRKTLLERVIQEINTQK---LELIGTFAASTAHEIRNPLTSIKGFIQLL 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 392 QQEVGK--DKECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVE 469
Cdd:COG5808 267 QEKYPEleDQKYFDIIQEEIQRINQIVSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIK 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 470 CCEIQLKHVFYSILQNSIEAIQNGQEIIISVKkHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRI 549
Cdd:COG5808 347 CDKDRIKQVLLNLIKNAIEAMKEGGKLTISIE-NDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRI 425
|
330 340
....*....|....*....|....*.
gi 500438795 550 IESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG5808 426 VEMHGGEIDIESEEGKGTTFTIRLPL 451
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
353-575 |
2.02e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 165.85 E-value: 2.02e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 353 MTELLKKSDtiNAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVG----KDKECLSLILSEISSIEKVIQEFLSIAKPNAA 428
Cdd:COG2205 5 ALEELEELE--RLKSEFLANVSHELRTPLTSILGAAELLLDEEDlspeERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 429 VFEPK----NLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHN 504
Cdd:COG2205 83 KLSLElepvDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500438795 505 StEIKISILDKGIGIPSERIKRLGEPFY----STKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG2205 163 D-GVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
327-577 |
1.14e-45 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 165.88 E-value: 1.14e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 327 YFEARLLPLFEDKIMIIVRDITERTIMTELLKksdtinavgQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD----KECL 402
Cdd:COG5002 135 SLRLSALLLGLLLLAAVERDITELERLEQMRR---------EFVANVSHELRTPLTSIRGYLELLLDGAADDpeerREYL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 403 SLILSEISSIEKVIQEFLSIAKPNAAV----FEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHV 478
Cdd:COG5002 206 EIILEEAERLSRLVNDLLDLSRLESGElkleKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQV 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 479 FYSILQNSIEAIQNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFY------STKEKGTGVGLMMSYRIIES 552
Cdd:COG5002 286 LTNLLDNAIKYTPEGGTITVSLREEDD-QVRISVRDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEA 364
|
250 260
....*....|....*....|....*
gi 500438795 553 HGGKISIKSQVGKGTTVTLFFPIYN 577
Cdd:COG5002 365 HGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
350-575 |
8.44e-38 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 145.70 E-value: 8.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 350 RTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQ---EVGKDKECLSLILSEISSIEKVIQEFLSIAKPN 426
Cdd:PRK10364 221 RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAErapAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 427 AAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNsT 506
Cdd:PRK10364 301 HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG-A 379
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500438795 507 EIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
368-575 |
7.59e-27 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 114.50 E-value: 7.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 368 QLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD-----KECLSLILSEISSIEKVIQ---EFLSIAKpNAAVFEPKNLCTIL 439
Cdd:COG4251 284 QFAYVASHDLREPLRKISGFSQLLEEDYGDKldeegREYLERIRDAAERMQALIDdllAYSRVGR-QELEFEPVDLNELL 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 440 DNVVDLISTQAIMKNIRITLnvdaENLL-VECCEIQLKHVFYSILQNSIEAIQNGQ--EIIISVKKHNsTEIKISILDKG 516
Cdd:COG4251 363 EEVLEDLEPRIEERGAEIEV----GPLPtVRGDPTLLRQVFQNLISNAIKYSRPGEppRIEIGAEREG-GEWVFSVRDNG 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500438795 517 IGIPSERIKRLGEPFY----STKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG4251 438 IGIDPEYAEKIFEIFQrlhsRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
472-575 |
1.75e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 103.88 E-value: 1.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 472 EIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTKE-----KGTGVGLMMS 546
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGD-HVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLSIV 81
|
90 100
....*....|....*....|....*....
gi 500438795 547 YRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
131-357 |
1.69e-25 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 105.88 E-value: 1.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 131 SILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIINNPkVMKLLHPYRPNRNDFRDW-----------EMDITCKNG 199
Cdd:COG2202 15 ALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKT-LRDLLPPEDDDEFLELLRaalagggvwrgELRNRRKDG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 200 EIKTIMWSNILHSIPTlGWNVGAIGI--DITRRKRMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCKVNSVSKFYV 277
Cdd:COG2202 94 SLFWVELSISPVRDED-GEITGFVGIarDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGY 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 278 PIEEFIGKKFQEILPVPIIKQFEKAINQ-IKTSSAPVLIDYSLQLDDEIY-YFEARLLPLFEDK----IMIIVRDITERT 351
Cdd:COG2202 173 SPEELLGKSLLDLLHPEDRERLLELLRRlLEGGRESYELELRLKDGDGRWvWVEASAVPLRDGGevigVLGIVRDITERK 252
|
....*.
gi 500438795 352 IMTELL 357
Cdd:COG2202 253 RAEEAL 258
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
323-575 |
4.15e-25 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 109.38 E-value: 4.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 323 DEIYYFEARLlplfedkimiivrDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKDKECL 402
Cdd:PRK13557 133 DLVYFFGSQL-------------DVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 403 SLILSEISSIE-------KVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLIStQAIMKNIRITLNVDAEnllVECCEI-- 473
Cdd:PRK13557 200 GRMARSVENIRaaaeraaTLTQQLLAFARKQRLEGRVLNLNGLVSGMGELAE-RTLGDAVTIETDLAPD---LWNCRIdp 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 474 -QLKHVFYSILQNSIEAIQNGQEIIISVKKHNSTE--------------IKISILDKGIGIPSERIKRLGEPFYSTKE-- 536
Cdd:PRK13557 276 tQAEVALLNVLINARDAMPEGGRVTIRTRNVEIEDedlamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEeg 355
|
250 260 270
....*....|....*....|....*....|....*....
gi 500438795 537 KGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK13557 356 KGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
472-574 |
5.23e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 99.75 E-value: 5.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 472 EIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNstEIKISILDKGIGIPSERIKRLGEPFYS---TKEKGTGVGLMMSYR 548
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG--ELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*.
gi 500438795 549 IIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
343-585 |
1.31e-24 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 109.00 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 343 IVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD---KECLSLILSEISSIEKVIQEF 419
Cdd:PRK13837 427 RRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHsraARYIDEIISAGARARLIIDQI 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 420 LSIAKPNAAVFEPKNLCTILDNVVDLISTqAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIIS 499
Cdd:PRK13837 507 LAFGRKGERNTKPFDLSELVTEIAPLLRV-SLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIS 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 500 VKKHNSTEIK--------------ISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGK 565
Cdd:PRK13837 586 LSRAKLRAPKvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGR 665
|
250 260
....*....|....*....|
gi 500438795 566 GTTVTLFFPIYNGDSVGDVS 585
Cdd:PRK13837 666 GTRFDVYLPPSSKVPVAPQA 685
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
475-573 |
3.29e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 97.29 E-value: 3.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTK----EKGTGVGLMMSYRII 550
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGD-GVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 500438795 551 ESHGGKISIKSQVGKGTTVTLFF 573
Cdd:cd00075 80 EAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
474-575 |
8.85e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 95.95 E-value: 8.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 474 QLKHVFYSILQNSIEAIQNGQEIIISVKKHnSTEIKISILDKGIGIPSERIKRLGEPFYSTKE--KGTGVGLMMSYRIIE 551
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAH-VDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQ 81
|
90 100
....*....|....*....|....
gi 500438795 552 SHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:cd16943 82 KHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-574 |
2.17e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 86.30 E-value: 2.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNG----QEIIISVKKHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRII 550
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGgcerRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 500438795 551 ESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
508-574 |
4.59e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 82.81 E-value: 4.59e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 500438795 508 IKISILDKGIGIPSERIKRLGEPFYSTKE--KGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
474-574 |
7.61e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 82.20 E-value: 7.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 474 QLKHVFYSILQNSIEAIQNGQ----EIIISVKKHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLMMSYRI 549
Cdd:cd16944 4 QISQVLTNILKNAAEAIEGRPsdvgEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKI 83
|
90 100
....*....|....*....|....*
gi 500438795 550 IESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16944 84 MEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-574 |
1.80e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 78.30 E-value: 1.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 495 EIIISVKK----HNSTEIKISILDKGIGIPSERIKRLGEPF------YSTKEKGTGVGLMMSYRIIESHGGKISIKSQVG 564
Cdd:cd16922 20 EVTLRVSLeeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAISKKLVELMGGDISVESEPG 99
|
90
....*....|
gi 500438795 565 KGTTVTLFFP 574
Cdd:cd16922 100 QGSTFTFTLP 109
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
316-575 |
3.49e-17 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 83.21 E-value: 3.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 316 DYSLQLDDEIYYFEARLLPLFEDKIMIIVRDI-TERTIMTELLKKSDTInAVGQLAAGVAHKVRNPLTVIKGFMQLLQQE 394
Cdd:PRK11073 80 EVTLVIDGRSHILSLTAQRLPEGMILLEMAPMdNQRRLSQEQLQHAQQV-AARDLVRGLAHEIKNPLGGLRGAAQLLSKA 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 395 VGKD--KECLSLILSEISSIEKVIQEFLSIAKPNAAVFEpkNLCTILDNVVDLISTQAiMKNIRIT---------LNVDA 463
Cdd:PRK11073 159 LPDPalTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTE--SIHKVAERVVQLVSLEL-PDNVRLIrdydpslpeLAHDP 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 464 EnllvecceiQLKHVFYSILQNSIEAI-QNGQEIIISVKKHNSTEI---------KISILDKGIGIPSERIKRLGEPFYS 533
Cdd:PRK11073 236 D---------QIEQVLLNIVRNALQALgPEGGTITLRTRTAFQLTLhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVS 306
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 500438795 534 TKEKGTGVGLMMSYRIIESHGGKISIKSQVGKgTTVTLFFPI 575
Cdd:PRK11073 307 GREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
330-574 |
6.70e-17 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 84.35 E-value: 6.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 330 ARLLPLFEDKI---------MIIVRDITE---RTIMTELlKKSDTINAVGQLAAGVAHKVRNPLTVIKGF-----MQLLQ 392
Cdd:COG4192 386 ARLLRVFRDQAiektqeletEIEERKRIEknlRQTQDEL-IQAAKMAVVGQTMTSLAHELNQPLNAMSMYlfsakKALEQ 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 393 QEVGKDKECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDaenLLVECCE 472
Cdd:COG4192 465 ENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHIPDD---LMVQGDQ 541
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 473 IQLKHVFYSILQNSIEAIQNGQEIIISVKKhNSTEIKISILDKGIGIPSerIKRLGEPFYSTKEKGTGVGLMMSYRIIES 552
Cdd:COG4192 542 VLLEQVLVNLLVNALDAVATQPQISVDLLS-NAENLRVAISDNGNGWPL--VDKLFTPFTTTKEVGLGLGLSICRSIMQQ 618
|
250 260
....*....|....*....|..
gi 500438795 553 HGGKISIKSQVGKGTTVTLFFP 574
Cdd:COG4192 619 FGGDLYLASTLERGAMVILEFN 640
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
341-575 |
9.91e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 82.20 E-value: 9.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 341 MIIVRDITERTIMTELLKKSDTINavgQLAAGVAHKVRNPLTVIKGFMQLlqqevGKDKECLSLILSEISSIEKVIQEFL 420
Cdd:COG3290 167 VATFRDRTELERLEEELEGVKELA---EALRAQRHDFRNHLHTISGLLQL-----GEYDEALEYIDEISEELQELIDSLL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 421 SiakpnaavfepknlcTILDNVVD--LISTQAIMKNIRITLNVDAENLLVECC--EIQLKHVFYSILQNSIEAIQNGQE- 495
Cdd:COG3290 239 S---------------RIGNPVLAalLLGKAARARERGIDLTIDIDSDLPDLPlsDTDLVTILGNLLDNAIEAVEKLPEe 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 496 ---IIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTK-EKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTL 571
Cdd:COG3290 304 errVELSIRDDGD-ELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTV 382
|
....
gi 500438795 572 FFPI 575
Cdd:COG3290 383 RLPK 386
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
318-574 |
2.23e-16 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 81.60 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 318 SLQLDDEiYYFEARLLPLFEDKIMIIVRDITErtiMTELLkksdtiNAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEV-- 395
Cdd:PRK11006 166 TLVLNNG-RHLEIRVMPYTEGQLLMVARDVTQ---MHQLE------GARRNFFANVSHELRTPLTVLQGYLEMMQDQPle 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 396 --GKDKeCLSLILSEISSIEKVIQEFLSIAKPNAAvfePKNLctiLDNVVD------LISTQAIM---KNIRITLNVDaE 464
Cdd:PRK11006 236 gaLREK-ALHTMREQTQRMEGLVKQLLTLSKIEAA---PTID---LNEKVDvpmmlrVLEREAQTlsqGKHTITFEVD-N 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 465 NLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKhNSTEIKISILDKGIGIPSERIKRLGEPFY------STKEKG 538
Cdd:PRK11006 308 SLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQR-VPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGG 386
|
250 260 270
....*....|....*....|....*....|....*.
gi 500438795 539 TGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:PRK11006 387 SGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-574 |
1.20e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 73.09 E-value: 1.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKkHNSTEIKISILDKGIGIPSERIKRLGEPFYSTK-----EKGTGVGLMMSYRI 549
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 500438795 550 IESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
374-575 |
1.95e-15 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 79.12 E-value: 1.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 374 AHKVRNPLTVIKGFMQLLQQEVGKDK--ECLSLILSEISSIEKVIQEFLSIAK----PNAAVFEPKNLCTILDNVVDLIS 447
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEDraRFTGNILTQSARLQQLIDRLLELARleqrQELEVLEPVALAALLEELVEARE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 448 TQAIMKNIRitLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNsTEIKISILDKGIGIPSERIKRL 527
Cdd:PRK11100 344 AQAAAKGIT--LRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDG-EQVALSVEDQGPGIPDYALPRI 420
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 500438795 528 GEPFYS-----TKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK11100 421 FERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
333-575 |
3.66e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 79.39 E-value: 3.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 333 LPLFEDKIMII-VRDITE-RTIMTEL-LKKSDTINAV---GQLAAGVAHKVRNPLTVIKGFMQLLQQE-VGKDK--ECLS 403
Cdd:PRK09959 673 LPASDHAVYICgWQDITEtRDLIHALeVERNKAINATvakSQFLATMSHEIRTPISSIMGFLELLSGSgLSKEQrvEAIS 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 404 LILSEISSIEKVIQEFLSIAKPNAAVFEPK----NLCTILDNVVDLISTQAIMKNIRITLNVD-AENLLVECCEIQLKHV 478
Cdd:PRK09959 753 LAYATGQSLLGLIGEILDVDKIESGNYQLQpqwvDIPTLVQNTCHSFGAIAASKSIALSCSSTfPDHYLVKIDPQAFKQV 832
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 479 FYSILQNSIEAIQNGQEIIISVKKH---NSTEIKISILDKGIGIPSERIKRLGEPFYST----KEKGTGVGLMMSYRIIE 551
Cdd:PRK09959 833 LSNLLSNALKFTTEGAVKITTSLGHiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIK 912
|
250 260
....*....|....*....|....
gi 500438795 552 SHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK09959 913 NMQGDLSLESHPGIGTTFTITIPV 936
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
137-575 |
5.08e-15 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 77.64 E-value: 5.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 137 PIMINAIDEKGNIIMWNRECELVTGYNAEEIINN-----------PKVMKLL-------HPYR----PNRNDFRDWEMDI 194
Cdd:TIGR02938 14 PLAISITDLKANILYANDAFTRITGYTKEEIIGKnesvlsnhttpPEVYQALwgslaeqKPWAgkllNRRKDGELYLAEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 195 TckngeiktimwsnILHSIPTLGWNVGAIGI--DITRRKRMEEKLKQTSNELELIFKAIPDLYFLSELDGTI-------- 264
Cdd:TIGR02938 94 T-------------VAPVLNEAGETTHFLGMhrDITELHRLEQVVANQKLLIESVVDAAPVAFVLLDPTGRVildnqeyk 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 265 ---KDCKVNSVSKFYVP-IEEFIGKKFQEILPV-PIIKQFEKAINQIKTSSAPVLIDYSLQLDDEIYYFEARLLPLFEDK 339
Cdd:TIGR02938 161 klaTDLRVKEPAHTVLDlLREAWREALAENWPQqLAFSNREARFDRGGGRPARWLSCTGSVIGMESDCADSFFCAAEQPY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 340 IMIIVRDITERTIMTE---------LLKKSDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKDKECLSL-ILSEI 409
Cdd:TIGR02938 241 LLLTIADISNLREEQErarlsalqaLMAEEERLEAIRETLSAAIHRLQGPMNLISAAISVLQRRGDDAGNPASAaMLQQA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 410 SSIEKVIQEFLS--IAKPNAAVFEPKNLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSI 487
Cdd:TIGR02938 321 LSAGREHMEALRqvIPQSPQEIVVPVNLNQILRDVITLSTPRLLAAGIVVDWQPAATLPAILGRELQLRSLFKALVDNAI 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 488 EAI-QNG---QEIIISVKKHNSTeIKISILDKGIGIPSERIKRLGEPFYSTK---EKGTGVGLMMSYRIIESHGGKISIK 560
Cdd:TIGR02938 401 EAMnIKGwkrRELSITTALNGDL-IVVSILDSGPGIPQDLRYKVFEPFFTTKggsRKHIGMGLSVAQEIVADHGGIIDLD 479
|
490
....*....|....*
gi 500438795 561 SQVGKGTTVTLFFPI 575
Cdd:TIGR02938 480 DDYSEGCRIIVEFRV 494
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
227-571 |
6.37e-15 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 78.06 E-value: 6.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 227 ITRRKRMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCkvNSVskfyvpIEEFIGKKFQEILPVPIIKQFEKAI-NQ 305
Cdd:PRK11091 140 IKEREETQIELEQQSSLLRSFLDASPDLVYYRNEDGEFSGC--NRA------MELLTGKSEKQLIGLTPKDVYSPEAaEK 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 306 IKTSSAPVL-----IDYSLQL---DDEIYYFEARLLPLFEDK-----IMIIVRDITERTIMTELLK-----KSDTInavg 367
Cdd:PRK11091 212 VIETDEKVFrhnvsLTYEQWLdypDGRKACFELRKVPFYDRVgkrhgLMGFGRDITERKRYQDALEkasrdKTTFI---- 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 368 qlaAGVAHKVRNPLTVIKGFMQ-LLQQEVGKDKE-----------CLSLILSEISSIEKVIQEFLSIAKpnaavfEPKNL 435
Cdd:PRK11091 288 ---STISHELRTPLNGIVGLSRiLLDTELTAEQRkylktihvsaiTLGNIFNDIIDMDKMERRKLQLDN------QPIDF 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 436 CTILDNVVDLISTQAIMKNIRITLNVDaENL--LVECCEIQLKHVFYSILQNSIEAIQNGqEIIISVKKHNSTEIKISIL 513
Cdd:PRK11091 359 TDFLADLENLSGLQAEQKGLRFDLEPL-LPLphKVITDGTRLRQILWNLISNAVKFTQQG-GVTVRVRYEEGDMLTFEVE 436
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500438795 514 DKGIGIPSERIKRLGEPFYSTKEK-------GTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTL 571
Cdd:PRK11091 437 DSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-574 |
3.54e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 68.97 E-value: 3.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQ-EIIISVKKHNSTEI---------KISILDKGIGIPSERIKRLGEPFYSTKEKGTGVGLM 544
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgEIILRTRTQRQVTLghprhrlalRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 500438795 545 MSYRIIESHGGKISIKSQVGKgTTVTLFFP 574
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-571 |
6.98e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 67.87 E-value: 6.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQE--IIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTKE--KGTGVGLMMSYRII 550
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENprIRIAARRLGG-RLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|.
gi 500438795 551 ESHGGKISIKSQVGKGTTVTL 571
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTF 100
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
360-578 |
3.89e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 71.14 E-value: 3.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 360 SDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQ--QEVGKDKECLSLIL-------SEISSIEKVIQEFLSIAK-PNAAV 429
Cdd:PRK09303 145 LEQLKFKDRVLAMLAHDLRTPLTAASLALETLElgQIDEDTELKPALIEqlqdqarRQLEEIERLITDLLEVGRtRWEAL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 430 -FEPK--NLCTILDNVVDLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNST 506
Cdd:PRK09303 225 rFNPQklDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQ 304
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500438795 507 EIKISILDKGIGIPSERIKRLGEPFY----STKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPIYNG 578
Cdd:PRK09303 305 KVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPVYRG 380
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-574 |
1.03e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 64.66 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISV-KKHNSTEIKISILDKGIGIPSERIKRLGEPFY---STKE-KGTGVGLMMSYRI 549
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVgAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQrlhSREEyEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 500438795 550 IESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
457-574 |
1.03e-12 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 70.71 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 457 ITLNVDAENLLVECCEIQLKHVFYSIL----QNSIEAI--QNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEP 530
Cdd:PRK11086 412 ITLIISEDSQLPDSGDEDQVHELITILgnliENALEAVggEEGGEISVSLHYRNG-WLHCEVSDDGPGIAPDEIDAIFDK 490
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 500438795 531 FYSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:PRK11086 491 GYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-580 |
1.04e-11 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 67.35 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 371 AGVAHKVRNPLTVIKGFMQLLQQEVGK-DKECLSLILSEISSIEKVIQEF--LSIAKPNAAVF--EPKNLCTILDNVVDL 445
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIQDGVRKfTPESVASLQAEVGTLTKLVDDLhqLSLSDEGALAYrkTPVDLVPLLEVAGGA 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 446 ISTQAIMKNIRITLNVDaENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNSTEIkISILDKGIGIPSERIK 525
Cdd:PRK10549 325 FRERFASRGLTLQLSLP-DSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR-LTFADSAPGVSDEQLQ 402
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 500438795 526 RLGEPFYSTKEK------GTGVGLMMSYRIIESHGGKISIK-SQVGkGTTVTLFFPIYNGDS 580
Cdd:PRK10549 403 KLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELPLERDLQ 463
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-573 |
1.22e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 61.65 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEaiQNGQEIIISVKKHNSTEIKISILDKGIGIPSERIKRLGEPFY---STKEKGTGVGLMMSYRIIE 551
Cdd:cd16940 14 LFLLLRNLVDNAVR--YSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVKRIVE 91
|
90 100
....*....|....*....|..
gi 500438795 552 SHGGKISIKSQVGKGTTVTLFF 573
Cdd:cd16940 92 LHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
127-575 |
1.85e-11 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 67.00 E-value: 1.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 127 DCLGSILQNMPIMINAIDEKGNII-MWNRECELVTGYNAEEIINNPkvmklLHPYRPNRN------DFRDW--------- 190
Cdd:PRK13560 332 DMLRAIIEAAPIAAIGLDADGNICfVNNNAAERMLGWSAAEVMGKP-----LPGMDPELNeefwcgDFQEWypdgrpmaf 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 191 ---EMDITCKNGEI----------------KTIMWSNILHSipTLGWNVGAIG--IDITRRKRMEEKLKQTSneleLIFK 249
Cdd:PRK13560 407 dacPMAKTIKGGKIfdgqevliereddgpaDCSAYAEPLHD--ADGNIIGAIAllVDITERKQVEEQLLLAN----LIVE 480
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 250 AIPDLYF-LSELDGTIKDCKVNSVSKF-YVPIEEFIGKKFQEILPVPI----------------IKQFEKAINQIKTSSA 311
Cdd:PRK13560 481 NSPLVLFrWKAEEGWPVELVSKNITQFgYEPDEFISGKRMFAAIIHPAdleqvaaevaefaaqgVDRFEQEYRILGKGGA 560
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 312 PVLID--YSLQLDDE--IYYFEArllplfedkimiIVRDITERTIMTELLKKSDTINAVgqLAAGVAHKVRNPLTVIKGF 387
Cdd:PRK13560 561 VCWIDdqSAAERDEEgqISHFEG------------IVIDISERKHAEEKIKAALTEKEV--LLKEIHHRVKNNLQIISSL 626
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 388 MQLLQQEVgKDKECLSLILSEISSIEkviqeflSIAKPNAAVFEPKNLCTI--LDNVVDLIS--TQAIMKNI-RITLNVD 462
Cdd:PRK13560 627 LDLQAEKL-HDEEAKCAFAESQDRIC-------AMALAHEKLYQSEDLADIdfLDYIESLTAhlKNSFAIDFgRIDCKID 698
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 463 AEN-------------LLVECCEIQLKHVFYSILQNSIEaiqngqeiiISVKKHNSTEIKISILDKGIGIPSERIKRLGE 529
Cdd:PRK13560 699 ADDgcldidkaipcglIISELLSNALKHAFPDGAAGNIK---------VEIREQGDGMVNLCVADDGIGLPAGFDFRAAE 769
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 500438795 530 PfystkekgtgVGLMMSYRIIESHGGKISIKSQvgKGTTVTLFFPI 575
Cdd:PRK13560 770 T----------LGLQLVCALVKQLDGEIALDSR--GGARFNIRFPM 803
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
474-574 |
3.75e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 60.17 E-value: 3.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 474 QLKHVFYSILQNSIEAIQNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTKEK------GTGVGLMMSY 547
Cdd:cd16946 4 RLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQ-EVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICH 82
|
90 100
....*....|....*....|....*...
gi 500438795 548 RIIESHGGKISIK-SQVGkGTTVTLFFP 574
Cdd:cd16946 83 NIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-574 |
4.76e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 59.91 E-value: 4.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKKHNSTEiKISILDKGIGIPSERIKRLGEPFY------STKEKGTGVGLMMSYR 548
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGA-RLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKH 79
|
90 100
....*....|....*....|....*.
gi 500438795 549 IIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16952 80 VMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
372-575 |
8.04e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 62.71 E-value: 8.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 372 GVAHKvrnpLTVIKGFMQLLQQEVGKDKECLSLILSEISS-IEKVIQEFLSIAK-PNAAVFEPKNLCTILDNVVDLISTQ 449
Cdd:COG4585 64 GVGQS----LSAIKLQLEAARRLLDADPEAAREELEEIRElAREALAELRRLVRgLRPPALDDLGLAAALEELAERLLRA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 450 AimkNIRITLNVDAENLLVEcceIQLKHVFYSILQnsiEAIQN------GQEIIISVKkHNSTEIKISILDKGIGIPSER 523
Cdd:COG4585 140 A---GIRVELDVDGDPDRLP---PEVELALYRIVQ---EALTNalkhagATRVTVTLE-VDDGELTLTVRDDGVGFDPEA 209
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 500438795 524 IKrlgepfystkekGTGVGLM-MSYRIiESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG4585 210 AP------------GGGLGLRgMRERA-EALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
363-424 |
2.64e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.45 E-value: 2.64e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500438795 363 INAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD---KECLSLILSEISSIEKVIQEFLSIAK 424
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDeeqREYLERIREEAERLLRLINDLLDLSR 65
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
131-237 |
4.70e-10 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 57.69 E-value: 4.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 131 SILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIINNpKVMKLLHPYRPNRNDFRDW------------EMDITCKN 198
Cdd:TIGR00229 7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGR-NVLELIPEEDREEVRERIErrlegepepvseERRVRRKD 85
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 500438795 199 GEIKTIMWSniLHSIPTLGWNVGAIGI--DITRRKRMEEKL 237
Cdd:TIGR00229 86 GSEIWVEVS--VSPIRTNGGELGVVGIvrDITERKEAEEAL 124
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
439-568 |
4.73e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 62.56 E-value: 4.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 439 LDNVVDLISTQAIMKNIRITLNVDA---ENLLVECCEIQlkHVFYSILQNSIEAIQNGQeIIISVKK----HNSTEIKIS 511
Cdd:PRK11107 372 LDEVVTLLAHSAHEKGLELTLNIDPdvpDNVIGDPLRLQ--QIITNLVGNAIKFTESGN-IDILVELralsNTKVQLEVQ 448
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 500438795 512 ILDKGIGIPSERIKRLGEPF------YSTKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTT 568
Cdd:PRK11107 449 IRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGST 511
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
369-575 |
4.92e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 61.85 E-value: 4.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 369 LAAGVAHKVRNPLTVIKgfmqLLQQEVGKDKECLSL-ILSEISSIEKVIQEFLSIAKP-NAAVFEPKNLCTILDNVVdli 446
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR----LATEMMSEEDGYLAEsINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVI--- 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 447 stQAIMKNIR-ITLNVDAENLLVECCEIQLKHVFYSILQNsieAIQNGQ-EIIISvKKHNSTEIKISILDKGIGIPSERI 524
Cdd:PRK09467 305 --AAESGYEReIETALQPGPIEVPMNPIAIKRALANLVVN---AARYGNgWIKVS-SGTEGKRAWFQVEDDGPGIPPEQL 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 500438795 525 KRLGEPFysTK------EKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK09467 379 KHLFQPF--TRgdsargSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
365-427 |
6.35e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 55.30 E-value: 6.35e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500438795 365 AVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKD--KECLSLILSEISSIEKVIQEFLSIAKPNA 427
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEeqREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
482-574 |
9.91e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.14 E-value: 9.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 482 ILQNSIEAI----QNGQEIIISVKKHNStEIKISILDKGIGIPSERIKRLGEPFYSTKE-KGTGVGLMMSYRIIESHGGK 556
Cdd:cd16915 8 LIDNALDALaatgAPNKQVEVFLRDEGD-DLVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSVERLGGS 86
|
90
....*....|....*...
gi 500438795 557 ISIKSQVGKGTTVTLFFP 574
Cdd:cd16915 87 ITVESEPGGGTTFSIRIP 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
373-575 |
1.79e-09 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 60.81 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 373 VAHKVRNPLTVIKGFMQLLQQEVGKDKE---------C----LSLI--LSEISSIEKViQEFLSIakpnaavfEPKNLCT 437
Cdd:PRK15347 405 ISHEIRTPLNGVLGALELLQNTPLTAEQmdladtarqCtlslLAIInnLLDFSRIESG-QMTLSL--------EETALLP 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 438 ILDNVVDLISTQAIMKNIRITLNVDAE-NLLVECCEIQLKHVFYSILQNSIEAIQNGqEIIISVKKHNSTEIkISILDKG 516
Cdd:PRK15347 476 LLDQAMLTIQGPAQSKSLTLRTFVGAHvPLYLHLDSLRLRQILVNLLGNAVKFTETG-GIRLRVKRHEQQLC-FTVEDTG 553
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 500438795 517 IGIPSERIKRLGEPFY--STKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK15347 554 CGIDIQQQQQIFTPFYqaDTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
365-427 |
2.31e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 53.72 E-value: 2.31e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 500438795 365 AVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVG--KDKECLSLILSEISSIEKVIQEFLSIAKPNA 427
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELseEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
248-350 |
2.41e-09 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 55.11 E-value: 2.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 248 FKAIPDLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEILPVPIIKQFEKAINQIKTSSAPVLIDYSLQLDDEIYY 327
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEERH 80
|
90 100
....*....|....*....|....*...
gi 500438795 328 FEARLLPLFEDK-----IMIIVRDITER 350
Cdd:pfam08448 81 YELRLTPLRDPDgevigVLVISRDITER 108
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
220-575 |
3.34e-09 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 59.53 E-value: 3.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 220 VGAIGIDITRRKRMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEILPVPIIKQF 299
Cdd:COG3920 144 LALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 300 EKAINQIKTSSAPVLIDYSLQLDDE-------IYYFEARLLPLFEDKIMIIVRDITERTIMTELLKKSDTINAVgqLAAG 372
Cdd:COG3920 224 LVLLAALLRLRAAVLEELERRRRARglgrlllLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKEL--LLRE 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 373 VAHKVRNPLTVIKGF--MQLLQQEVGKDKECLSLILSEISSIEKViQEFLSIAKPNAAVfepkNLCTILDNVVDLISTQA 450
Cdd:COG3920 302 LHHRVKNNLQVVSSLlrLQARRADDPEAREALEESQNRIQALALV-HELLYQSEDWEGV----DLRDYLRELLEPLRDSY 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 451 IMKNIRITLNVDAENLLVECCeIQLKHVFYSILQNSIE----AIQNGqEIIISVKKHNSTeIKISILDKGIGIPSErikr 526
Cdd:COG3920 377 GGRGIRIELDGPDVELPADAA-VPLGLILNELVTNALKhaflSGEGG-RIRVSWRREDGR-LRLTVSDNGVGLPED---- 449
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 500438795 527 lgepfySTKEKGTGVGLMMSYRIIESHGGKISIKSqvGKGTTVTLFFPI 575
Cdd:COG3920 450 ------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPL 490
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-574 |
1.40e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 52.45 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 499 SVKKHNSTE---IKISILDKGIGIPSERIKRLGEPFY----STKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTL 571
Cdd:cd16950 19 WVEVSSDGEgnrTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRISDAHGGSLTLANRAGGGLCARI 98
|
...
gi 500438795 572 FFP 574
Cdd:cd16950 99 ELP 101
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
486-575 |
1.94e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 56.95 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 486 SIEAIQNGQEIIISVKKHNSTeIKISILDKGIGIPSERIKRLGEPFySTKEKGTGVGLMMSYRIIESHGGK---ISIKSQ 562
Cdd:COG2972 352 GIEPKEGGGTIRISIRKEGDR-LVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRNVRERLKLYYGEeygLEIESE 429
|
90
....*....|...
gi 500438795 563 VGKGTTVTLFFPI 575
Cdd:COG2972 430 PGEGTTVTIRIPL 442
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
371-575 |
2.41e-08 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 57.22 E-value: 2.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 371 AGVAHKVRNPLTVIKGFMQLLQ------------QEVGKDKECLSLILSEI---SSIEkviqeflsIAKPNAAV----FE 431
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLLAdnpalnaqrddlRAITDSGESLLTILNDIldySAIE--------AGGKNVSVsdepFE 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 432 PKNLctiLDNVVDLISTQAIMKNIRITLNV-DAENLLVECCEIQLKHVFYSILQNSIEAIQNGqeIIISVKKHNSTEIKI 510
Cdd:PRK11466 521 PRPL---LESTLQLMSGRVKGRPIRLATDIaDDLPTALMGDPRRIRQVITNLLSNALRFTDEG--SIVLRSRTDGEQWLV 595
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 500438795 511 SILDKGIGIPSERIKRLGEPFY--STKEKGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-571 |
2.43e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 52.08 E-value: 2.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKKhNSTEIKISILDKGIGIPSERIKRLGEPFYS-----TKEKGTGVGLMMSYRI 549
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEA-DTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEV 83
|
90 100
....*....|....*....|...
gi 500438795 550 IESHGGKISIKS-QVGKGTTVTL 571
Cdd:cd16945 84 AQLHGGRITLRNrPDGVLAFLTL 106
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
370-574 |
2.74e-08 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 56.32 E-value: 2.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 370 AAGVAHKVRNPLT--VIKGFMQLLQQEVGKD-KECLSLILSEISSIEKVIQE--FLSIAKPNAAVFE--PKNLCTILDNV 442
Cdd:PRK09835 266 SADIAHEIRTPITnlITQTEIALSQSRSQKElEDVLYSNLEELTRMAKMVSDmlFLAQADNNQLIPEkkMLDLADEVGKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 443 VDLISTQAIMKNIriTLNVDAENLLVECCEIQLKHVFYSILQNSIEAIQNGQEIIISVKKHNSTeIKISILDKGIGIPSE 522
Cdd:PRK09835 346 FDFFEAWAEERGV--ELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQ-VQLVVENPGTPIAPE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 500438795 523 RIKRLGEPFYST------KEKGTGVGLMMSYRIIESHGGKISIKSQVgKGTTVTLFFP 574
Cdd:PRK09835 423 HLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
369-566 |
3.27e-08 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 56.58 E-value: 3.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 369 LAAGVAHKVRNPLTVIKG----FMQLLQQEVGKDKECLSLILSEISSIEKVIQEFLSIAKPNAAVFEPKNLCTILDNVVD 444
Cdd:PRK10490 667 LLAALSHDLRTPLTVLFGqaeiLTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVG 746
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 445 --LISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNSIEaiQNGQEIIISVKKHNSTE-IKISILDKGIGIPS 521
Cdd:PRK10490 747 saLQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVK--YAGAQAEIGIDAHVEGErLQLDVWDNGPGIPP 824
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 500438795 522 ERIKRLGEPF-YSTKEK---GTGVGLMMSYRIIESHGGKISIKSQVGKG 566
Cdd:PRK10490 825 GQEQLIFDKFaRGNKESaipGVGLGLAICRAIVEVHGGTIWAENRPEGG 873
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
507-574 |
5.22e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 51.17 E-value: 5.22e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500438795 507 EIKISILDKGIGIPSERIKRLGEPFYSTKEK------GTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16949 30 QWTITITDDGPGVPEDQLEQIFLPFYRVDSArdresgGTGLGLAIAERAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
475-574 |
1.05e-07 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 51.96 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQE--------IIISVKKhNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEK--------- 537
Cdd:cd16929 44 LYYILFELLKNAMRATVESHGddsddlppIKVTVAK-GDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQpslddfsdl 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 500438795 538 ----------GTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16929 123 isgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
232-400 |
1.22e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 53.10 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 232 RMEEKLKQTSNELELIFKAIPDLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEILPVPIIKQFEKAINQIKTSSA 311
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 312 PVLIDYSLQL-DDEIYYFEARLLPLFEDK-----IMIIVRDITERTIMTELLKKSDTINAVGQLAAGVAHKVRNPLTVIK 385
Cdd:COG2202 81 VWRGELRNRRkDGSLFWVELSISPVRDEDgeitgFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRIL 160
|
170
....*....|....*
gi 500438795 386 GFMQLLQQEVGKDKE 400
Cdd:COG2202 161 YVNPAAEELLGYSPE 175
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
474-574 |
1.66e-07 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 49.80 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 474 QLKHVFYSILQNSIEAIQNGQEIIISVKKHNSTEIKISILDKGIGIPSERIKRLGEPFY------STKEKGTGVGLMMSY 547
Cdd:cd16925 4 KYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRqgdgssTRAHGGTGLGLSIVK 83
|
90 100
....*....|....*....|....*..
gi 500438795 548 RIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16925 84 EFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
371-579 |
2.00e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 54.21 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 371 AGVAHKVRNPLTVIKGFMQLLQ-QEVGKDKECL--------SLILSEISSI---EKVIQEFLSIaKPNAavFEPKNLCT- 437
Cdd:PRK10841 452 ATVSHELRTPLYGIIGNLDLLQtKELPKGVDRLvtamnnssSLLLKIISDIldfSKIESEQLKI-EPRE--FSPREVINh 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 438 ILDNVVDLISTQA------IMKNIRITLNVDAenllvecceIQLKHVFYSILQNSIEAIQNGQeIIISVKKHNSTeIKIS 511
Cdd:PRK10841 529 ITANYLPLVVKKRlglycfIEPDVPVALNGDP---------MRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDY-LSFR 597
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 500438795 512 ILDKGIGIPSERIKRLGEPFYSTKE------KGTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPIYNGD 579
Cdd:PRK10841 598 VRDTGVGIPAKEVVRLFDPFFQVGTgvqrnfQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPLYGAQ 671
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
496-574 |
3.28e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 50.66 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 496 IIISVKkHNSTEIKISILDKGIGIPSERIKR------------------------LGEPFYSTKEK-----GTGVGLMMS 546
Cdd:cd16916 72 ITLRAE-HQGNQVVIEVSDDGRGIDREKIREkaierglitadeaatlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVV 150
|
90 100
....*....|....*....|....*...
gi 500438795 547 YRIIESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:cd16916 151 KRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
129-243 |
6.37e-07 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 52.08 E-value: 6.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 129 LGSILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIIN--------NPKVMKLLHPYRPNRNDFRDwemditcKNGE 200
Cdd:COG3829 13 LEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGknvtelipNSPLLEVLKTGKPVTGVIQK-------TGGK 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 500438795 201 IKTImwsnILHSIPTL--GWNVGAIGI--DITRRKRMEEKLKQTSNE 243
Cdd:COG3829 86 GKTV----IVTAIPIFedGEVIGAVETfrDITELKRLERKLREEELE 128
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
466-574 |
6.60e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 48.19 E-value: 6.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 466 LLVECCeiqLKHVFYSIlqnsieaiQNGQEIIISVKKhNSTEIKISILDKGIGIPSERIKRLGE-PFYStkEKGTGVGLM 544
Cdd:cd16957 8 VLVENA---IRHAFPKR--------KENNEVRVVVKK-DQHKVHVSVSDNGQGIPEERLDLLGKtTVTS--EKGTGTALE 73
|
90 100 110
....*....|....*....|....*....|...
gi 500438795 545 -MSYRIIESHG--GKISIKSQVGKGTTVTLFFP 574
Cdd:cd16957 74 nLNRRLIGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
373-576 |
8.11e-07 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 51.86 E-value: 8.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 373 VAHKVRNPLTVIKGFMQLLQQEVGKDKEcLSLILSEISSIEKVIQEFLSIAK---PNAAVFEPKNLCTILDNVVDLISTQ 449
Cdd:PRK09470 250 ISHELRTPLTRLQLATALLRRRQGESKE-LERIETEAQRLDSMINDLLVLSRnqqKNHLERETFKANSLWSEVLEDAKFE 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 450 AIMKNIRITLNVDAENLLVECCEIQLKHVFYSILQNsieAIQNGQ-EIIISVKKHNSTeIKISILDKGIGIPSERIKRLG 528
Cdd:PRK09470 329 AEQMGKSLTVSAPPGPWPINGNPNALASALENIVRN---ALRYSHtKIEVAFSVDKDG-LTITVDDDGPGVPEEEREQIF 404
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 500438795 529 EPFYSTKEK------GTGVGLMMSYRIIESHGGKISI-KSQVGkGTTVTLFFPIY 576
Cdd:PRK09470 405 RPFYRVDEArdresgGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLPLY 458
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-557 |
1.17e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 47.57 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKKHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKG------TGVGLMMSYR 548
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQ 80
|
....*....
gi 500438795 549 IIESHGGKI 557
Cdd:cd16953 81 IIEAHGGIS 89
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-571 |
2.86e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 46.74 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKkHNSTEIKISILDKGIGIPSERIKRLGEPFYSTKE------KGTGVGLMMSYR 548
Cdd:cd16947 21 LQRILKNLISNAIKYGSDGKFLGMTLR-EDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGLTITKR 99
|
90 100
....*....|....*....|....*
gi 500438795 549 IIESHGGKISIKSQVGKGT--TVTL 571
Cdd:cd16947 100 LAESMGGSIYVNSKPYEKTvfTVTL 124
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-573 |
5.70e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 45.53 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKKhNSTEIKISILDKGIGIPSERIKRLGEPFYSTKEKGT-----GVGLMMSYRI 549
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYD-EEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIAKNL 83
|
90 100
....*....|....*....|....
gi 500438795 550 IESHGGKISIKSQVGKGTTVTLFF 573
Cdd:cd16975 84 VEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| PRK10547 |
PRK10547 |
chemotaxis protein CheA; Provisional |
503-581 |
6.13e-06 |
|
chemotaxis protein CheA; Provisional
Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 49.34 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 503 HNSTEIKISILDKGIGIPSERI--KRLGE-------------------PFYSTKEK-----GTGVGLMMSYRIIESHGGK 556
Cdd:PRK10547 425 HQGGNICIEVTDDGAGLNRERIlaKAASQglavsenmsdeevgmlifaPGFSTAEQvtdvsGRGVGMDVVKRNIQEMGGH 504
|
90 100
....*....|....*....|....*....
gi 500438795 557 ISIKSQVGKGTTVTLFFP----IYNGDSV 581
Cdd:PRK10547 505 VEIQSKQGKGTTIRILLPltlaILDGMSV 533
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
496-571 |
9.54e-06 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 45.61 E-value: 9.54e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 500438795 496 IIISVKKHNsTEIKISILDKGIGIPSerIKRLGEPFYSTKEKGTGVGlmMSYRIIESHGGKISIKSQVGKGTTVTL 571
Cdd:cd16942 63 VSISVIIED-GVVHLTVRDEGVGIPD--IEEARQPLFTTKPELERSG--MGFTIMENFMDEVIVESEVNKGTTVYL 133
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
131-227 |
1.08e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 44.72 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 131 SILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIINNPKVMKLLHPYR-----------PNRNDFRDWEMDITCKNG 199
Cdd:pfam00989 5 AILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDaevaellrqalLQGEESRGFEVSFRVPDG 84
|
90 100
....*....|....*....|....*....
gi 500438795 200 EIKTI-MWSNILHSIPTLGWNVGAIGIDI 227
Cdd:pfam00989 85 RPRHVeVRASPVRDAGGEILGFLGVLRDI 113
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
487-575 |
1.27e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 48.25 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 487 IEAIQNGQEIIISVKkhnsteikisilDKGIGIPSERIKR----LG--------------------EPFYSTKEK----- 537
Cdd:COG0643 313 LSAYHEGGRVVIEVS------------DDGRGLDLEKIRAkaieKGlitaeeaaalsdeellelifAPGFSTAEEvtdls 380
|
90 100 110
....*....|....*....|....*....|....*...
gi 500438795 538 GTGVGLMMSYRIIESHGGKISIKSQVGKGTTVTLFFPI 575
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
129-179 |
1.59e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.77 E-value: 1.59e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 500438795 129 LGSILQNMPIMINAIDEKGNIIMWNRECELVTGYNAEEIINNPkVMKLLHP 179
Cdd:smart00091 3 LRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKS-LLELIHP 52
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
474-574 |
2.72e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 47.16 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 474 QLKHVFYSILQNSIEAIQ--NGQEIIISVKKHNSTEIKISILDKGIGIPserikrlgepfySTKEKGTGVGL-MMSYRiI 550
Cdd:PRK10935 468 QQVHLLQIIREATLNAIKhaNASEIAVSCVTNPDGEHTVSIRDDGIGIG------------ELKEPEGHYGLnIMQER-A 534
|
90 100
....*....|....*....|....
gi 500438795 551 ESHGGKISIKSQVGKGTTVTLFFP 574
Cdd:PRK10935 535 ERLGGTLTISQPPGGGTTVSLTFP 558
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
136-207 |
9.53e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 41.85 E-value: 9.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 136 MPIMINAIDEKGNIIMWNRECELVTGYNAEEIINNPkVMKLLHPYRP-----------NRNDFRDWEMDITCKNGEIKTI 204
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKS-LLDLIHPEDReelrerlenllSGGEPVTLEVRLRRKDGSVIWV 79
|
...
gi 500438795 205 MWS 207
Cdd:cd00130 80 LVS 82
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
332-574 |
1.35e-04 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 44.57 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 332 LLPLFEDKIMIIVRDITerTIMTELLKK-SDTINAVGQLAAGVAHKVRNPLTVIKGFMQLLQQEVGKDkeCLSLIlSEIS 410
Cdd:PRK10755 104 LTPIAIHSSTLEIEAVT--SALNQLVSRlTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHID--VAPLI-ARLD 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 411 SIEKVIQEFLSIAKPNAAV----FEPKNLctiLDNVV----DLISTQAIMKNIRITLNVDAENLLVECCEIQLKHVFYSI 482
Cdd:PRK10755 179 QMMHTVEQLLQLARAGQSFssghYQTVKL---LEDVIlpsqDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 483 LQNSIEAIQNGQEIIISVKKHNSTEIkISILDKGIGIPSERIKRLGEPF--YSTKEKGTGVGLMMSYRIIESHGGKISIK 560
Cdd:PRK10755 256 VENAHRYSPEGSTITIKLSQEDGGAV-LAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQ 334
|
250
....*....|....*
gi 500438795 561 S-QVGKGTTVTLFFP 574
Cdd:PRK10755 335 NrQERSGTRAWVWLP 349
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-574 |
1.22e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 38.60 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 493 GQEII-ISVKKHNSTEIKISILDKGIGIPSERIKRLgepfYSTKEKGTGVGLM-MSYRIIESHGGKISIKSQVGKGTTVT 570
Cdd:cd16955 23 GKGVVkISVKKQLKNRLHIAVEDNGIGISPKVIERV----EQDEMPGNKIGLLnVHQRLKLGYGEGLHIRSRPDPGTLIA 98
|
....
gi 500438795 571 LFFP 574
Cdd:cd16955 99 FYIP 102
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
251-347 |
4.62e-03 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 36.84 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 251 IPDLYFLSELDGTIKDCKVNSVSKFYVPIEEFIGKKFQEILPVPIIKQFEKAINQIKTSSAPVLIDYSLQL-DDEIYYFE 329
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRkDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 500438795 330 ARLLPLFED-----KIMIIVRDI 347
Cdd:cd00130 81 VSLTPIRDEggeviGLLGVVRDI 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
475-562 |
5.26e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 36.60 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 475 LKHVFYSILQNSIEAIQNGQEIIISVKKHNSTeIKISILDKGIGIPSERIKRLGEPFY----STKEKGTGVGLMMSYRII 550
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDV-VNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAII 79
|
90
....*....|..
gi 500438795 551 ESHGGKISIKSQ 562
Cdd:cd16923 80 ELHGGSASAEYD 91
|
|
| PBP1_CaSR |
cd06364 |
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ... |
287-461 |
9.51e-03 |
|
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.
Pssm-ID: 380587 [Multi-domain] Cd Length: 473 Bit Score: 38.78 E-value: 9.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 287 FQEILP-VPIIKQFEKAINQIKTSSAPVLIDYSLQLDdeiyyfearLLPLFEDkimIIVRDITERT-------IMTELLK 358
Cdd:cd06364 202 FSETIPrTYSQEKILRIVEVIKKSTAKVIVVFSSEGD---------LEPLIKE---LVRQNITGRQwiaseawITSSLLA 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 500438795 359 KSDTINAVGQlAAGVAhkVRNplTVIKGFMQLLQQeVGKDKeclslilseiSSIEKVIQEF--------LSIAKPNAAVF 430
Cdd:cd06364 270 TPEYFPVLGG-TIGFA--IRR--GEIPGLKEFLLR-VHPSK----------SPSNPFVKEFweetfncsLSSSSKSNSSS 333
|
170 180 190
....*....|....*....|....*....|.
gi 500438795 431 EPKNLCTILDNVVDLISTQAIMKNIRITLNV 461
Cdd:cd06364 334 SSRPPCTGSENLENVQNPYTDVSQLRISYNV 364
|
|
| |
