|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
5-271 |
1.34e-104 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 308.72 E-value: 1.34e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVIDKKqeNIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERyPRERFTIATKFPTFAIQT 84
Cdd:cd19096 2 VLGFGTMRLPESDDD--SIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEG-PREKFYLATKLPPWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 EDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQGGivkkchLFEHMQKWKEEGKIRHIGFSFHDSPEILDQILA 164
Cdd:cd19096 79 AEDFRRILEESLKRLGVDYIDFYLLHGLNSPEWLEKARKGG------LLEFLEKAKKEGLIRHIGFSFHDSPELLKEILD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 165 EHPeVEFVQIIINYFDWEsyFIASKKCYEVIRKHGKKVIVMEPVKGGFLAQIPETAKQALCSENpkFSPAGWALRFAGSL 244
Cdd:cd19096 153 SYD-FDFVQLQYNYLDQE--NQAGRPGIEYAAKKGMGVIIMEPLKGGGLANNPPEALAILCGAP--LSPAEWALRFLLSH 227
|
250 260
....*....|....*....|....*..
gi 507804023 245 DDEIAVLSGMSTLDQMEDNIKTMKDFS 271
Cdd:cd19096 228 PEVTTVLSGMSTPEQLDENIAAADEFE 254
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
6-291 |
1.38e-90 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 276.70 E-value: 1.38e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPVIDKkqenidfEQLNAMVDKFIENGFTYFDTSYVYHNgkSEAALRKSVveRYPRERFTIATKFPTFaIQTE 85
Cdd:COG1453 16 LGFGGMRLPRKDE-------EEAEALIRRAIDNGINYIDTARGYGD--SEEFLGKAL--KGPRDKVILATKLPPW-VRDP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 86 DQVEEIFSQQLENLGTNYVDYYLLHLLNT-KFYNGSDSQGGIvkkchlFEHMQKWKEEGKIRHIGFSFHDSPEILDQILA 164
Cdd:COG1453 84 EDMRKDLEESLKRLQTDYIDLYLIHGLNTeEDLEKVLKPGGA------LEALEKAKAEGKIRHIGFSTHGSLEVIKEAID 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 165 EHpEVEFVQIIINYFDWEsyFIASKKCYEVIRKHGKKVIVMEPVKGGFLAQIPETAKQALCsenPKFSPAGWALRFAGSl 244
Cdd:COG1453 158 TG-DFDFVQLQYNYLDQD--NQAGEEALEAAAEKGIGVIIMKPLKGGRLANPPEKLVELLC---PPLSPAEWALRFLLS- 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 507804023 245 DDEIA-VLSGMSTLDQMEDNIKTMKDFSTLDEKEKNMLLQIAKEQKAT 291
Cdd:COG1453 231 HPEVTtVLSGMSTPEQLDENLKTADNLEPLTEEELAILERLAEELGEL 278
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
6-276 |
8.63e-42 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 148.23 E-value: 8.63e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPvidKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERY-PRERFTIATKFPT----- 79
Cdd:pfam00248 1 IGLGTWQLG---GGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPvKRDKVVIATKVPDgdgpw 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 80 -FAIQTEDqVEEIFSQQLENLGTNYVDYYLLHllntkfyngsdSQGGIVKKCHLFEHMQKWKEEGKIRHIGFSFHDsPEI 158
Cdd:pfam00248 78 pSGGSKEN-IRKSLEESLKRLGTDYIDLYYLH-----------WPDPDTPIEETWDALEELKKEGKIRAIGVSNFD-AEQ 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 159 LDQILaEHPEVEFVQIIINYFDWESyfIASKKCYEVIRKHGKKVIVMEPVKGGFL--------------------AQIPE 218
Cdd:pfam00248 145 IEKAL-TKGKIPIVAVQVEYNLLRR--RQEEELLEYCKKNGIPLIAYSPLGGGLLtgkytrdpdkgpgerrrllkKGTPL 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507804023 219 TAK-----QALCSENPKfSPAGWALRFAGSLDDEIAVLSGMSTLDQMEDNIK------TMKDFSTLDEK 276
Cdd:pfam00248 222 NLEalealEEIAKEHGV-SPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGalefplSDEEVARIDEL 289
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-265 |
2.61e-40 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 142.62 E-value: 2.61e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPvidkkqeNIDFEQLNAMVDKFIENGFTYFDTSYVYhnGKSEAALRKSVVERypRERFTIATKFPTFaiqTE 85
Cdd:cd19100 14 LGFGGGPLG-------RLSQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIGKALKGR--RDKVFLATKTGAR---DY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 86 DQVEEIFSQQLENLGTNYVDYYLLHLLNTKF-YNGSDSQGGIvkkchlFEHMQKWKEEGKIRHIGFSFHdSPEILdQILA 164
Cdd:cd19100 80 EGAKRDLERSLKRLGTDYIDLYQLHAVDTEEdLDQVFGPGGA------LEALLEAKEEGKIRFIGISGH-SPEVL-LRAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 165 EHPEVEFVQIIINYFDWEsYFIASKKCYEVIRKHGKKVIVMEPVKGGFLAQI-PETAKQalcsenpkfspagwALRFAGS 243
Cdd:cd19100 152 ETGEFDVVLFPINPAGDH-IDSFREELLPLAREKGVGVIAMKVLAGGRLLSGdPLDPEQ--------------ALRYALS 216
|
250 260
....*....|....*....|..
gi 507804023 244 LDDEIAVLSGMSTLDQMEDNIK 265
Cdd:cd19100 217 LPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-267 |
5.17e-40 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 142.34 E-value: 5.17e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPVIDkkqenidfeqlNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPRERFTIATKF-PTFAIQT 84
Cdd:cd19105 16 LGFGGGGLPRES-----------PELLRRALDLGINYFDTAEGYGNGNSEEIIGE-ALKGLRRDKVFLATKAsPRLDKKD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 EDQVEEIFSQQLENLGTNYVDYYLLHllntkfynGSDSQGGIVKKCHLFEHMQKWKEEGKIRHIGFSFHDS-PEILDQiL 163
Cdd:cd19105 84 KAELLKSVEESLKRLQTDYIDIYQLH--------GVDTPEERLLNEELLEALEKLKKEGKVRFIGFSTHDNmAEVLQA-A 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 164 AEHPEVEFVQIIINYFDWESYFIAS-KKCYevirKHGKKVIVMEPVKGGFLAQIPETAKQAlcsenPKFSPAGWALRFAG 242
Cdd:cd19105 155 IESGWFDVIMVAYNFLNQPAELEEAlAAAA----EKGIGVVAMKTLAGGYLQPALLSVLKA-----KGFSLPQAALKWVL 225
|
250 260
....*....|....*....|....*.
gi 507804023 243 SlDDEI-AVLSGMSTLDQMEDNIKTM 267
Cdd:cd19105 226 S-NPRVdTVVPGMRNFAELEENLAAA 250
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
5-265 |
1.37e-37 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 135.34 E-value: 1.37e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPvidkkqENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERYPRERFTIATKF------- 77
Cdd:cd06660 2 RLGLGTMTFG------GDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKGghppggd 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 78 PTFAIQTEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGsdsqggivkkcHLFEHMQKWKEEGKIRHIGFSFHDSPE 157
Cdd:cd06660 76 PSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVE-----------ETLEALNELVREGKIRYIGVSNWSAER 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 158 I--LDQILAEH--PEVEFVQIIINYFDWEsyfIASKKCYEVIRKHGKKVIVMEPVKGGflaqipetakqalcsenpkfsP 233
Cdd:cd06660 145 LaeALAYAKAHglPGFAAVQPQYSLLDRS---PMEEELLDWAEENGLPLLAYSPLARG---------------------P 200
|
250 260 270
....*....|....*....|....*....|..
gi 507804023 234 AGWALRFAGSLDDEIAVLSGMSTLDQMEDNIK 265
Cdd:cd06660 201 AQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
30-265 |
3.90e-36 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 131.83 E-value: 3.90e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSE----AALRKsvveryPRERFTIATKFPtFAIQTEDQVEEIFSQQ---------L 96
Cdd:cd19086 28 RALRAALDLGINFFDTADVYGDGHSErllgKALKG------RRDKVVIATKFG-NRFDGGPERPQDFSPEyireaveasL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 97 ENLGTNYVDYYLLHllntkfyNGSDSqggIVKKCHLFEHMQKWKEEGKIRHIGFSFhDSPEILDQILaEHPEVEFVQIII 176
Cdd:cd19086 101 KRLGTDYIDLYQLH-------NPPDE---VLDNDELFEALEKLKQEGKIRAYGVSV-GDPEEALAAL-RRGGIDVVQVIY 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 177 NYFDWEsyfiASKKCYEVIRKHGKKVIVMEPVKGGFLaqipeTAKqalcsenpkfsPAGWALRFAGSLDDEIAVLSGMST 256
Cdd:cd19086 169 NLLDQR----PEEELFPLAEEHGVGVIARVPLASGLL-----TGK-----------LAQAALRFILSHPAVSTVIPGARS 228
|
....*....
gi 507804023 257 LDQMEDNIK 265
Cdd:cd19086 229 PEQVEENAA 237
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
5-265 |
2.97e-30 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 117.97 E-value: 2.97e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPvidKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPRERFTIATKF------- 77
Cdd:COG0667 15 RLGLGTMTFG---GPWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGE-ALKGRPRDDVVIATKVgrrmgpg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 78 PTFAIQTEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKfyngsdsqggiVKKCHLFEHMQKWKEEGKIRHIGFSFHDSPE 157
Cdd:COG0667 91 PNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPD-----------TPIEETLGALDELVREGKIRYIGVSNYSAEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 158 ILD--QILAEHPEVEFVQIIINYFD---WESYFiaskkcyEVIRKHGKKVIVMEPVKGGFLA-------QIPETAKQALC 225
Cdd:COG0667 160 LRRalAIAEGLPPIVAVQNEYSLLDrsaEEELL-------PAARELGVGVLAYSPLAGGLLTgkyrrgaTFPEGDRAATN 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 226 SENPKFSPAGW--------------------ALRFAGSLDDEIAVLSGMSTLDQMEDNIK 265
Cdd:COG0667 233 FVQGYLTERNLalvdalraiaaehgvtpaqlALAWLLAQPGVTSVIPGARSPEQLEENLA 292
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
6-266 |
8.62e-26 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 104.24 E-value: 8.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRlpvIDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYhnGKSEAALRKsVVERYPRERFTIATKF-------P 78
Cdd:cd19095 3 LGLGTSG---IGRVWGVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGR-ALAGLRRDDLFIATKVgthgeggR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 79 TFAIQTEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSdsqggivkkchLFEHMQKWKEEGKIRHIGFSfHDSPEI 158
Cdd:cd19095 77 DRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGE-----------VLETLEDLKAAGKVRYIGVS-GDGEEL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 159 LDQIlaEHPEVEFVQIiinyfdweSYFIASKKCYEVI---RKHGKKVIVMEPVKGGFLAQI--------PETAKQALCSE 227
Cdd:cd19095 145 EAAI--ASGVFDVVQL--------PYNVLDREEEELLplaAEAGLGVIVNRPLANGRLRRRvrrrplyaDYARRPEFAAE 214
|
250 260 270
....*....|....*....|....*....|....*....
gi 507804023 228 NPKFSPAGWALRFAGSLDDEIAVLSGMSTLDQMEDNIKT 266
Cdd:cd19095 215 IGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-268 |
1.29e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 104.15 E-value: 1.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 16 IDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYhnGKSEAALRKSVVERyprERFTIATKFP---TFAIQTEDQVEEIF 92
Cdd:cd19097 16 IANKSGKPSEKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLKRL---DKFKIITKLPplkEDKKEDEAAIEASV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 93 SQQLENLGTNYVDYYLLHLLNTKFYNGSDsqggivkkchLFEHMQKWKEEGKIRHIGFSFHdSPEILDQILaEHPEVEFV 172
Cdd:cd19097 91 EASLKRLKVDSLDGLLLHNPDDLLKHGGK----------LVEALLELKKEGLIRKIGVSVY-SPEELEKAL-ESFKIDII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 173 QIIINYFDWesYFIASKKCyEVIRKHGKKVIV----------MEPVKG-GFLAQIPETAKQ--ALCSENpKFSPAGWALR 239
Cdd:cd19097 159 QLPFNILDQ--RFLKSGLL-AKLKKKGIEIHArsvflqglllMEPDKLpAKFAPAKPLLKKlhELAKKL-GLSPLELALG 234
|
250 260
....*....|....*....|....*....
gi 507804023 240 FAGSLDDEIAVLSGMSTLDQMEDNIKTMK 268
Cdd:cd19097 235 FVLSLPEIDKIVVGVDSLEQLKEIIAAFK 263
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
21-165 |
5.25e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 97.79 E-value: 5.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 21 ENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPRERFTIATKF-PTFAIQTEDQVEEIFSQQLENL 99
Cdd:cd19103 27 NHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGE-FLKRYPREDYIISTKFtPQIAGQSADPVADMLEGSLARL 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507804023 100 GTNYVDYYLLHllntkfyNGSDSQGGIvkkchlfEHMQKWKEEGKIRHIGFSFHDSPEI--LDQILAE 165
Cdd:cd19103 106 GTDYIDIYWIH-------NPADVERWT-------PELIPLLKSGKVKHVGVSNHNLAEIkrANEILAK 159
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
9-281 |
1.01e-19 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 87.67 E-value: 1.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 9 GFMRLPVIDKKQEnidFEQLNamvdKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPRERFTIATKF-PTFAiqTEDQ 87
Cdd:cd19072 16 GGMSKDYSDDKKA---IEALR----YAIELGINLIDTAEMYGGGHAEELVGK-AIKGFDREDLFITTKVsPDHL--KYDD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 88 VEEIFSQQLENLGTNYVDYYLLHLLNTkfyngsdsqggIVKKCHLFEHMQKWKEEGKIRHIGFSFHDSPEILD-QILAEH 166
Cdd:cd19072 86 VIKAAKESLKRLGTDYIDLYLIHWPNP-----------SIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEaQSYLKK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 167 PEVEFVQIIINYFDWEsyfiASKKCYEVIRKHGKKVIVMEPVKGGFLAQIPETAK-QALCSENPKfSPAGWALRFAGSLD 245
Cdd:cd19072 155 GPIVANQVEYNLFDRE----EESGLLPYCQKNGIAIIAYSPLEKGKLSNAKGSPLlDEIAKKYGK-TPAQIALNWLISKP 229
|
250 260 270
....*....|....*....|....*....|....*.
gi 507804023 246 DEIAVlSGMSTLDQMEDNIKTMkDFsTLDEKEKNML 281
Cdd:cd19072 230 NVIAI-PKASNIEHLEENAGAL-GW-ELSEEDLQRL 262
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
5-265 |
1.53e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 88.14 E-value: 1.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVIDkkqeNIDFEQLNAmVDKFIENGFTYFDTSYVYHNGKSE----AALRKSVVE-RYPRERFTIATK--- 76
Cdd:cd19099 5 SLGLGTYRGDSDD----ETDEEYREA-LKAALDSGINVIDTAINYRGGRSErligKALRELIEKgGIKRDEVVIVTKagy 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 77 --------------FPTFAIQTEDQVEEI---------------FSQQLENLGTNYVDYYLLH--------LLNTKFYNg 119
Cdd:cd19099 80 ipgdgdeplrplkyLEEKLGRGLIDVADSaglrhcispayledqIERSLKRLGLDTIDLYLLHnpeeqlleLGEEEFYD- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 120 sdsqggIVKKchLFEHMQKWKEEGKIRHIGFS------------FHDSPEILDQILAE----HPEVEFVQIIINYFDWES 183
Cdd:cd19099 159 ------RLEE--AFEALEEAVAEGKIRYYGIStwdgfrappalpGHLSLEKLVAAAEEvggdNHHFKVIQLPLNLLEPEA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 184 YFIASKKCY------EVIRKHGKKVIVMEPVKGGFLAQIPetAKQALCSENPKFSPAGWALRFAGSLDDEIAVLSGMSTL 257
Cdd:cd19099 231 LTEKNTVKGealsllEAAKELGLGVIASRPLNQGQLLGEL--RLADLLALPGGATLAQRALQFARSTPGVDSALVGMRRP 308
|
....*...
gi 507804023 258 DQMEDNIK 265
Cdd:cd19099 309 EHVDENLA 316
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
21-287 |
1.75e-18 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 84.95 E-value: 1.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 21 ENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSE----AALRKsvveryPRERFTIATKFPTFAIqTEDQVEEIFSQQL 96
Cdd:cd19085 18 GDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEevlgKALKG------RRDDVVIATKVSPDNL-TPEDVRKSCERSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 97 ENLGTNYVDYYLLHLLNTKFYngsdsqggiVKKChlFEHMQKWKEEGKIRHIGFSFHDSPEIldQILAEHPEVEFVQIII 176
Cdd:cd19085 91 KRLGTDYIDLYQIHWPSSDVP---------LEET--MEALEKLKEEGKIRAIGVSNFGPAQL--EEALDAGRIDSNQLPY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 177 NYFdWESYFiaskkcYEVI---RKHGKKVIVMEPVKGGFL-------AQIPETAK-----------------------QA 223
Cdd:cd19085 158 NLL-WRAIE------YEILpfcREHGIGVLAYSPLAQGLLtgkfssaEDFPPGDArtrlfrhfepgaeeetfealeklKE 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507804023 224 LCSENpKFSPAGWALRFAGSLDDEIAVLSGMSTLDQMEDNIKTMKDfsTLDEKEKNMLLQIAKE 287
Cdd:cd19085 231 IADEL-GVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDL--ELSPSVLERLDEISDP 291
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
22-277 |
5.07e-18 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 82.53 E-value: 5.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 22 NIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKS-EAALRKSVVeryPRERFTIATKFPTFAiQTEDQVEEIFSQQLENLG 100
Cdd:cd19071 10 KLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEvGEAIRESGV---PREELFITTKLWPTD-HGYERVREALEESLKDLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 101 TNYVDYYLLHllntkfyngsdSQGGIVKKCHLFEHMQKWK------EEGKIRHIGFS-FHdsPEILDQILAE---HPEVe 170
Cdd:cd19071 86 LDYLDLYLIH-----------WPVPGKEGGSKEARLETWRaleelvDEGLVRSIGVSnFN--VEHLEELLAAariKPAV- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 171 fVQIIIN-YFDWEsyfiaskkcyEVIRKHGKKVIVME---PVKGGFLAQIPETAKQALCSENPKfSPAGWALRFAgsLDD 246
Cdd:cd19071 152 -NQIELHpYLQQK----------ELVEFCKEHGIVVQaysPLGRGRRPLLDDPVLKEIAKKYGK-TPAQVLLRWA--LQR 217
|
250 260 270
....*....|....*....|....*....|.
gi 507804023 247 EIAVLSGMSTLDQMEDNIKTMkDFStLDEKE 277
Cdd:cd19071 218 GVVVIPKSSNPERIKENLDVF-DFE-LSEED 246
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
24-261 |
2.31e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 81.93 E-value: 2.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 24 DFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATKFPTFAIQTED---QVEEIFSQQLENLG 100
Cdd:cd19104 30 TREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGL--PAGPYITTKVRLDPDDLGDiggQIERSVEKSLKRLK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 101 TNYVDYYLLH----------LLNTKFYNGSDSQGGIVkkcHLFEHMQKwkeEGKIRHIGFSFHDSPEILDQILaEHPEVE 170
Cdd:cd19104 108 RDSVDLLQLHnrigderdkpVGGTLSTTDVLGLGGVA---DAFERLRS---EGKIRFIGITGLGNPPAIRELL-DSGKFD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 171 FVQIIINYFDWeSYFIA------SKKCYEVI---RKHGKKVIVMEPVKGGFLA--------QIPET------------AK 221
Cdd:cd19104 181 AVQVYYNLLNP-SAAEArprgwsAQDYGGIIdaaAEHGVGVMGIRVLAAGALTtsldrgreAPPTSdsdvaidfrraaAF 259
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 507804023 222 QALCSENPKfSPAGWALRFAGSLDDEIAVLSGMSTLDQME 261
Cdd:cd19104 260 RALAREWGE-TLAQLAHRFALSNPGVSTVLVGVKNREELE 298
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
22-277 |
3.13e-17 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 81.03 E-value: 3.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 22 NIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATKF-------PTFAIQ-TEDQVEEIFS 93
Cdd:cd19084 21 EVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR--RDDVVIATKCglrwdggKGVTKDlSPESIRKEVE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 94 QQLENLGTNYVDYYLLHllntkfyngsdSQGGIVKKCHLFEHMQKWKEEGKIRHIGFSFHDspeiLDQI--LAEHPEVEF 171
Cdd:cd19084 99 QSLRRLQTDYIDLYQIH-----------WPDPNTPIEETAEALEKLKKEGKIRYIGVSNFS----VEQLeeARKYGPIVS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 172 VQIIINYFDWESYfiasKKCYEVIRKHGKKVIVMEPVKGGFLA----QIPETAKQALCSENPKFSPAGWA--LRFAGSLd 245
Cdd:cd19084 164 LQPPYSMLEREIE----EELLPYCRENGIGVLPYGPLAQGLLTgkykKEPTFPPDDRRSRFPFFRGENFEknLEIVDKL- 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 507804023 246 DEIA-----------------------VLSGMSTLDQMEDNIKTMkDFsTLDEKE 277
Cdd:cd19084 239 KEIAekygkslaqlaiawtlaqpgvtsAIVGAKNPEQLEENAGAL-DW-ELTEEE 291
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
4-265 |
3.47e-17 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 80.68 E-value: 3.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 4 GKLGFGFMRLPVidkkqeniDFEQLNAMVDKFIENGFTYFDTSYVYhnGKSEAALRKsVVERYPRERFTIATK---FPT- 79
Cdd:cd19090 6 GTAGLGGVFGGV--------DDDEAVATIRAALDLGINYIDTAPAY--GDSEERLGL-ALAELPREPLVLSTKvgrLPEd 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 80 FAIQTEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQGGIVkkchlfEHMQKWKEEGKIRHIGFSFHDsPEIL 159
Cdd:cd19090 75 TADYSADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAPGGAL------EALLELKEEGLIKHIGLGGGP-PDLL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 160 DQILAEhpeVEFVqIIINYFDW-------ESYFIAskkcyeVIRKHGKKVIVMEPVKGGFLAQIP--------------- 217
Cdd:cd19090 148 RRAIET---GDFD-VVLTANRYtlldqsaADELLP------AAARHGVGVINASPLGMGLLAGRPpervrytyrwlspel 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 507804023 218 -ETAKQ--ALCSENPKFSPAgWALRFAGSLDDEIAVLSGMSTLDQMEDNIK 265
Cdd:cd19090 218 lDRAKRlyELCDEHGVPLPA-LALRFLLRDPRISTVLVGASSPEELEQNVA 267
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
5-151 |
6.89e-17 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 80.29 E-value: 6.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLpvidkkQENIDFEQLNAMVDKFIENGFTYFDTSYVY----HNGKSEAALRKSVVERYPRERFTIATK--FP 78
Cdd:cd19082 2 RIVLGTADF------GTRIDEEEAFALLDAFVELGGNFIDTARVYgdwvERGASERVIGEWLKSRGNRDKVVIATKggHP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 79 TFAIQTEDQV--EEI---FSQQLENLGTNYVDYYLLHllntkfyngSDSQ----GGIVkkchlfEHMQKWKEEGKIRHIG 149
Cdd:cd19082 76 DLEDMSRSRLspEDIradLEESLERLGTDYIDLYFLH---------RDDPsvpvGEIV------DTLNELVRAGKIRAFG 140
|
..
gi 507804023 150 FS 151
Cdd:cd19082 141 AS 142
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
21-265 |
4.09e-15 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 74.94 E-value: 4.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 21 ENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPRERFTIATK--FPTFAIQTE-----DQVEEIFS 93
Cdd:cd19074 17 GQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGK-ALKGWPRESYVISTKvfWPTGPGPNDrglsrKHIFESIH 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 94 QQLENLGTNYVDYYLLHllntKFyngsDSQGGIVKKCHLFEHMqkwKEEGKIRHIGFSFHDSPEIL------DQILAEHP 167
Cdd:cd19074 96 ASLKRLQLDYVDIYYCH----RY----DPETPLEETVRAMDDL---IRQGKILYWGTSEWSAEQIAeahdlaRQFGLIPP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 168 EVEfvQIIINYF--DWESYFIaskkcyEVIRKHGKKVIVMEPVKGGFLA------QIPETAKQALCSENPKF-------- 231
Cdd:cd19074 165 VVE--QPQYNMLwrEIEEEVI------PLCEKNGIGLVVWSPLAQGLLTgkyrdgIPPPSRSRATDEDNRDKkrrlltde 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 507804023 232 -----------------SPA----GWALRfagslDDEI-AVLSGMSTLDQMEDNIK 265
Cdd:cd19074 237 nlekvkklkpiadelglTLAqlalAWCLR-----NPAVsSAIIGASRPEQLEENVK 287
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
21-151 |
4.27e-15 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 74.96 E-value: 4.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 21 ENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERYPRERFTIATKF-PTFAIQTEDQVEEIFSQQLENL 99
Cdd:cd19093 21 GEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATKFaPLPWRLTRRSVVKALKASLERL 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 507804023 100 GTNYVDYYLLHllntkFYNGSDSQggivkKCHLFEHMQKWKEEGKIRHIGFS 151
Cdd:cd19093 101 GLDSIDLYQLH-----WPGPWYSQ-----IEALMDGLADAVEEGLVRAVGVS 142
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
22-278 |
7.16e-15 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 74.12 E-value: 7.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 22 NIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPRERFTIATK--------FPTF---AIQTEDQVEE 90
Cdd:cd19163 29 PVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGK-ALKGIPRDSYYLATKvgrygldpDKMFdfsAERITKSVEE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 91 ifsqQLENLGTNYVDYYLLHllNTKFyngSDSQGGIVKKChlFEHMQKWKEEGKIRHIGFSFHdsP-EILDQILAEHPEV 169
Cdd:cd19163 108 ----SLKRLGLDYIDIIQVH--DIEF---APSLDQILNET--LPALQKLKEEGKVRFIGITGY--PlDVLKEVLERSPVK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 170 efVQIIINY-----FDWEsyfiaSKKCYEVIRKHGKKVIVMEPVKGGFL------------AQIPETAKQA--LCSENPK 230
Cdd:cd19163 175 --IDTVLSYchytlNDTS-----LLELLPFFKEKGVGVINASPLSMGLLtergppdwhpasPEIKEACAKAaaYCKSRGV 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 507804023 231 fSPAGWALRFAGSLDDEIAVLSGMSTLDQMEDNIKTMkdFSTLDEKEK 278
Cdd:cd19163 248 -DISKLALQFALSNPDIATTLVGTASPENLRKNLEAA--EEPLDAHLL 292
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
5-174 |
7.10e-14 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 70.85 E-value: 7.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVidkkqenidfEQLNAMVDKFIENGFTYFDTSYVYHNgksEA----ALRKSVVeryPRERFTIATKFPTF 80
Cdd:COG0656 7 ALGLGTWQLPG----------EEAAAAVRTALEAGYRHIDTAAMYGN---EEgvgeAIAASGV---PREELFVTTKVWND 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 81 AiQTEDQVEEIFSQQLENLGTNYVDYYLLH------LLNTkfyngsdsqggivkkchlFEHMQKWKEEGKIRHIGFS-FH 153
Cdd:COG0656 71 N-HGYDDTLAAFEESLERLGLDYLDLYLIHwpgpgpYVET------------------WRALEELYEEGLIRAIGVSnFD 131
|
170 180
....*....|....*....|..
gi 507804023 154 dsPEILDQILAEHPEVEFV-QI 174
Cdd:COG0656 132 --PEHLEELLAETGVKPAVnQV 151
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
36-278 |
9.77e-14 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 70.38 E-value: 9.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNgksEAALRKSVVE-RYPRERFTIATKFPTFAIQTEDqVEEIFSQQLENLGTNYVDYYLLHLLNT 114
Cdd:cd19073 24 LELGYRHIDTAEIYNN---EAEVGEAIAEsGVPREDLFITTKVWRDHLRPED-LKKSVDRSLEKLGTDYVDLLLIHWPNP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 115 KfYNGSDSqggivkkchlFEHMQKWKEEGKIRHIGFS-FhdSPEILDQILaehpEVEFVQIIINYFDWESYFIASKKCyE 193
Cdd:cd19073 100 T-VPLEET----------LGALKELKEAGKVKSIGVSnF--TIELLEEAL----DISPLPIAVNQVEFHPFLYQAELL-E 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 194 VIRKHGKKVIVMEPVKGGFLAQIPETAKQAlcsENPKFSPAGWALRFAGSLDdeIAVLSGMSTLDQMEDNIKTMkDFS-T 272
Cdd:cd19073 162 YCRENDIVITAYSPLARGEVLRDPVIQEIA---EKYDKTPAQVALRWLVQKG--IVVIPKASSEDHLKENLAIF-DWElT 235
|
....*.
gi 507804023 273 LDEKEK 278
Cdd:cd19073 236 SEDVAK 241
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
5-151 |
1.87e-13 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 70.31 E-value: 1.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVIDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERYPRERFTIATKFptFAIQT 84
Cdd:cd19079 14 RLCLGCMSFGDPKWRPWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRDEVVIATKV--YFPMG 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507804023 85 EDQVEEIFSQQ---------LENLGTNYVDYYLLHLL--NTKFYNGSDSQGGIVKkchlfehmqkwkeEGKIRHIGFS 151
Cdd:cd19079 92 DGPNGRGLSRKhimaevdasLKRLGTDYIDLYQIHRWdyETPIEETLEALHDVVK-------------SGKVRYIGAS 156
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
30-284 |
6.06e-13 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 69.04 E-value: 6.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSEAALRKSV-VERYPRERFTIATKFPTFAIQ---TEDQVEEIFSQQLENLGTNYVD 105
Cdd:PLN02587 35 ASVREAFRLGINFFDTSPYYGGTLSEKVLGKALkALGIPREKYVVSTKCGRYGEGfdfSAERVTKSVDESLARLQLDYVD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 106 yyLLHLLNTKFynGSDSQggIVKKChlFEHMQKWKEEGKIRHIGFS---FHDSPEILDQIlaehpEVEFVQIIINYFdwe 182
Cdd:PLN02587 115 --ILHCHDIEF--GSLDQ--IVNET--IPALQKLKESGKVRFIGITglpLAIFTYVLDRV-----PPGTVDVILSYC--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 183 SYFIASKKCYEVI---RKHGKKVIVMEPVKGGFL------------AQIPETAKQAL--CSENPKfSPAGWALRFAGSLD 245
Cdd:PLN02587 179 HYSLNDSSLEDLLpylKSKGVGVISASPLAMGLLtengppewhpapPELKSACAAAAthCKEKGK-NISKLALQYSLSNK 257
|
250 260 270
....*....|....*....|....*....|....*....
gi 507804023 246 DEIAVLSGMSTLDQMEDNIKTMKDFSTLDeKEKNMLLQI 284
Cdd:PLN02587 258 DISTTLVGMNSVQQVEENVAAATELETSG-IDEELLSEV 295
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
36-206 |
4.50e-12 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 65.72 E-value: 4.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNGKS-EAALRKSVVeryPRERFTIATKfptfAIQTEDQVEEIFSQQLENLGTNYVDYYLLHllNT 114
Cdd:cd19120 35 LKAGFRHIDTAEMYGNEKEvGEALKESGV---PREDLFITTK----VSPGIKDPREALRKSLAKLGVDYVDLYLIH--SP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 115 KFYNGSDsqggivkkchlFEHMQKWKE------EGKIRHIGFS-FHdsPEILDQILAEHPevefVQIIINYFDWESYFIA 187
Cdd:cd19120 106 FFAKEGG-----------PTLAEAWAElealkdAGLVRSIGVSnFR--IEDLEELLDTAK----IKPAVNQIEFHPYLYP 168
|
170 180
....*....|....*....|
gi 507804023 188 -SKKCYEVIRKHGkkvIVME 206
Cdd:cd19120 169 qQPALLEYCREHG---IVVS 185
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
6-151 |
5.37e-12 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 65.66 E-value: 5.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPvidkkQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEA----ALRKSVVErypRERFTIATKfptFA 81
Cdd:cd19092 9 LVLGCMRLA-----DWGESAEELLSLIEAALELGITTFDHADIYGGGKCEElfgeALALNPGL---REKIEIQTK---CG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 82 IQTEDQVEEI------FS---------QQLENLGTNYVDYYLLH----LLNTKfyngsdsqgGIVKKchlFEHMQKwkeE 142
Cdd:cd19092 78 IRLGDDPRPGrikhydTSkehilasveGSLKRLGTDYLDLLLLHrpdpLMDPE---------EVAEA---FDELVK---S 142
|
....*....
gi 507804023 143 GKIRHIGFS 151
Cdd:cd19092 143 GKVRYFGVS 151
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
6-265 |
6.98e-12 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 65.70 E-value: 6.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLpvidkkQENIDFEQLNAMVDKFIENGFTYFDTSYVY-------HNGKSEAALRKSVVERYPRERFTIATK-- 76
Cdd:cd19081 12 LCLGTMVF------GWTADEETSFALLDAFVDAGGNFIDTADVYsawvpgnAGGESETIIGRWLKSRGKRDRVVIATKvg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 77 FPTF-------AIQTEDQVEEIfsqqLENLGTNYVDYYLLHLlntkfyngsDSQGgivkkCHLFEHMQ---KWKEEGKIR 146
Cdd:cd19081 86 FPMGpngpglsRKHIRRAVEAS----LRRLQTDYIDLYQAHW---------DDPA-----TPLEETLGalnDLIRQGKVR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 147 HIGFS-FhdSPEILDQILA---EH--PEVEFVQiiinyfdwESYFIASKKCYE-----VIRKHGKKVIVMEPVKGGFL-- 213
Cdd:cd19081 148 YIGASnY--SAWRLQEALElsrQHglPRYVSLQ--------PEYNLVDRESFEgellpLCREEGIGVIPYSPLAGGFLtg 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 214 -----AQIPETAKQALcSENPKFSPAGWALrfagsLD--DEIA-----------------------VLSGMSTLDQMEDN 263
Cdd:cd19081 218 kyrseADLPGSTRRGE-AAKRYLNERGLRI-----LDalDEVAaehgatpaqvalawllarpgvtaPIAGARTVEQLEDL 291
|
..
gi 507804023 264 IK 265
Cdd:cd19081 292 LA 293
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
22-151 |
1.03e-11 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 65.33 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 22 NIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATKfptFAIQTEDQVEEIFSQQ------ 95
Cdd:cd19091 35 GVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGR--RDDVLIATK---VRGRMGEGPNDVGLSRhhiira 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 96 ----LENLGTNYVDYYLLHllntkfynGSDSQGGIVKKCHLFEHMQKWkeeGKIRHIGFS 151
Cdd:cd19091 110 veasLKRLGTDYIDLYQLH--------GFDALTPLEETLRALDDLVRQ---GKVRYIGVS 158
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
22-162 |
1.04e-11 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 65.13 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 22 NIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEaALRKSVVERYPRERFTIATK--------------FPTFaiqTEDQ 87
Cdd:cd19083 29 NLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSE-ELVGEVLKEYNRNEVVIATKgahkfggdgsvlnnSPEF---LRSA 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507804023 88 VEEifsqQLENLGTNYVDYYLLHllntkFYNGSdsqggiVKKCHLFEHMQKWKEEGKIRHIGFSFHDspeiLDQI 162
Cdd:cd19083 105 VEK----SLKRLNTDYIDLYYIH-----FPDGE------TPKAEAVGALQELKDEGKIRAIGVSNFS----LEQL 160
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
4-265 |
1.71e-11 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 64.55 E-value: 1.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 4 GKLGFGFMRLPVIdkkQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSE----AALRksvveRYPRERFTIATKF-- 77
Cdd:cd19152 1 PKLGFGTAPLGNL---YEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEerlgAALR-----ELGREDYVISTKVgr 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 78 ---------PTF-----------AIQ--TEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQggivkkcHLFEH 135
Cdd:cd19152 73 llvplqevePTFepgfwnplpfdAVFdySYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDE-------HFAQA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 136 MQ-------KWKEEGKIRHIGFSFHDsPEILDQILaEHPEVEFVQIIINY--FDWEsyfiASKKCYEVIRKHGKKVIVME 206
Cdd:cd19152 146 IKgafraleELREEGVIKAIGLGVND-WEVILRIL-EEADLDWVMLAGRYtlLDHS----AARELLPECEKRGVKVVNAG 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507804023 207 PVKGGFLA---------------QIPETAKQ--ALCsENPKFSPAGWALRFAGSLDDEIAVLSGMSTLDQMEDNIK 265
Cdd:cd19152 220 PFNSGFLAggdnfdyyeygpappELIARRDRieALC-EQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVA 294
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
30-165 |
1.95e-11 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 63.83 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHN-GKSEAALRKSVVeryPRERFTIATKFPTfAIQTEDQVEEIFSQQLENLGTNYVDYYL 108
Cdd:cd19132 24 EAVVAALQAGYRLLDTAFNYENeGAVGEAVRRSGV---PREELFVTTKLPG-RHHGYEEALRTIEESLYRLGLDYVDLYL 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 507804023 109 LHLLNTKfyngsdsQGGIVKKchlFEHMQKWKEEGKIRHIGFS-FhdSPEILDQILAE 165
Cdd:cd19132 100 IHWPNPS-------RDLYVEA---WQALIEAREEGLVRSIGVSnF--LPEHLDRLIDE 145
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
26-151 |
3.30e-11 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 63.70 E-value: 3.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHNgksEAALRKSVVE-----RYPRERFTIATKFPTFAIQTEdQVEEIFSQQLENLG 100
Cdd:cd19155 25 EEIETAVDTALEAGYRHIDTAYVYRN---EAAIGNVLKKwidsgKVKREELFIVTKLPPGGNRRE-KVEKFLLKSLEKLQ 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507804023 101 TNYVDYYLLHLLNTKFYNGSDS----QGGIVKKCHLFEHMQKWK------EEGKIRHIGFS 151
Cdd:cd19155 101 LDYVDLYLIHFPVGSLSKEDDSgkldPTGEHKQDYTTDLLDIWKameaqvDQGLTRSIGLS 161
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
26-268 |
1.14e-10 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 61.80 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsvvERYPRERFTIATKFPTFA--IQTEDQVEEIFSQQLENLGTNY 103
Cdd:cd19075 20 EAAAELLDAFLERGHTEIDTARVYPDGTSEELLGE---LGLGERGFKIDTKANPGVggGLSPENVRKQLETSLKRLKVDK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 104 VDYYLLHllntkfynGSDSQGGIVKKChlfEHMQKWKEEGKIRHIGFSFHDSPEILD--QILAEH----PEVefVQIIIN 177
Cdd:cd19075 97 VDVFYLH--------APDRSTPLEETL---AAIDELYKEGKFKEFGLSNYSAWEVAEivEICKENgwvlPTV--YQGMYN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 178 YF--DWESyfiaskKCYEVIRKHGKKVIVMEPVKGGFLA----QIPETAK------------------------------ 221
Cdd:cd19075 164 AItrQVET------ELFPCLRKLGIRFYAYSPLAGGFLTgkykYSEDKAGggrfdpnnalgklyrdrywkpsyfealekv 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 507804023 222 QALCSENpKFSPAGWALRFA-------GSLDDeiAVLSGMSTLDQMEDNIKTMK 268
Cdd:cd19075 238 EEAAEKE-GISLAEAALRWLyhhsaldGEKGD--GVILGASSLEQLEENLAALE 288
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
36-178 |
2.27e-10 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 61.14 E-value: 2.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYhnGKSEA----ALrKSVVERYPRERFTIATKFPTFAIQ----TEDQVEEIFSQQLENLGTNYVDYY 107
Cdd:cd19164 44 LELGIRAFDTSPYY--GPSEIilgrAL-KALRDEFPRDTYFIITKVGRYGPDdfdySPEWIRASVERSLRRLHTDYLDLV 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507804023 108 LLHllNTKFYNGSDSQGGIvkkCHLFehmqKWKEEGKIRHIGFSFHDSPEILD-QILAEHPEVEFVQIIINY 178
Cdd:cd19164 121 YLH--DVEFVADEEVLEAL---KELF----KLKDEGKIRNVGISGYPLPVLLRlAELARTTAGRPLDAVLSY 183
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
5-174 |
2.44e-10 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 60.91 E-value: 2.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLP--VIDKKQEnidfEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERyPRERFTIATKFPTFAI 82
Cdd:cd19145 14 AQGLGCMGLSgdYGAPKPE----EEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDG-PREKVQLATKFGIHEI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 83 Q--------TEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKfyngsdsqggiVKKCHLFEHMQKWKEEGKIRHIGFSfHD 154
Cdd:cd19145 89 GgsgvevrgDPAYVRAACEASLKRLDVDYIDLYYQHRIDTT-----------VPIEITMGELKKLVEEGKIKYIGLS-EA 156
|
170 180
....*....|....*....|
gi 507804023 155 SPEILDQILAEHPeVEFVQI 174
Cdd:cd19145 157 SADTIRRAHAVHP-ITAVQL 175
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
30-173 |
5.15e-10 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 59.92 E-value: 5.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATKFPtfAIQTEDQ-----------VEEIFSQQLEN 98
Cdd:cd19076 36 ATLHRALELGVTFLDTADMYGPGTNEELLGKALKDR--RDEVVIATKFG--IVRDPGSgfrgvdgrpeyVRAACEASLKR 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507804023 99 LGTNYVDYYLLHllntkfynGSDSQGGIVKKchlFEHMQKWKEEGKIRHIGFSfHDSPEILDQILAEHPeVEFVQ 173
Cdd:cd19076 112 LGTDVIDLYYQH--------RVDPNVPIEET---VGAMAELVEEGKVRYIGLS-EASADTIRRAHAVHP-ITAVQ 173
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
5-240 |
6.92e-10 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 58.99 E-value: 6.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVIDkkqenidfEQLNAmVDKFIENGFTYFDTSYVYHNGKSEA-ALRKSVVeryPRERFTIATKfptfaIQ 83
Cdd:cd19126 11 WLGLGVFQTPDGD--------ETERA-VQTALENGYRSIDTAAIYKNEEGVGeAIRESGV---PREELFVTTK-----LW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 84 TEDQ----VEEIFSQQLENLGTNYVDYYLLHLlntkfyngsDSQGGIVKKchlFEHMQKWKEEGKIRHIGFS-FHdsPEI 158
Cdd:cd19126 74 NDDQrarrTEDAFQESLDRLGLDYVDLYLIHW---------PGKDKFIDT---WKALEKLYASGKVKAIGVSnFQ--EHH 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 159 LDQILAehpeVEFVQIIINYFDWESYFIaSKKCYEVIRKHGkkvIVME---PVKGGFLAQIPETAKQAlcsENPKFSPAG 235
Cdd:cd19126 140 LEELLA----HADVVPAVNQVEFHPYLT-QKELRGYCKSKG---IVVEawsPLGQGGLLSNPVLAAIG---EKYGKSAAQ 208
|
....*
gi 507804023 236 WALRF 240
Cdd:cd19126 209 VVLRW 213
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
5-277 |
8.05e-10 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 58.81 E-value: 8.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLpvidkkqeniDFEQLNAMVDKFIENGFTYFDTSYVYHNGKS-EAALRKSVVeryPRERFTIATKFPTFAIQ 83
Cdd:cd19140 10 ALGLGTYPL----------TGEECTRAVEHALELGYRHIDTAQMYGNEAQvGEAIAASGV---PRDELFLTTKVWPDNYS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 84 TED---QVEEifsqQLENLGTNYVDYYLLHLLNtkfyngsdSQGGIVKKCHLFEHMQkwkEEGKIRHIGFS-FhdSPEIL 159
Cdd:cd19140 77 PDDflaSVEE----SLRKLRTDYVDLLLLHWPN--------KDVPLAETLGALNEAQ---EAGLARHIGVSnF--TVALL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 160 DQILAEHPEvefvQIIINYFDWESYfIASKKCYEVIRKHGKKVIVMEPVKGGFLAQIPETAKQAlcsENPKFSPAGWALR 239
Cdd:cd19140 140 REAVELSEA----PLFTNQVEYHPY-LDQRKLLDAAREHGIALTAYSPLARGEVLKDPVLQEIG---RKHGKTPAQVALR 211
|
250 260 270
....*....|....*....|....*....|....*....
gi 507804023 240 FAgsLDDE-IAVLSGMSTLDQMEDNIKTMkDFsTLDEKE 277
Cdd:cd19140 212 WL--LQQEgVAAIPKATNPERLEENLDIF-DF-TLSDEE 246
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
6-213 |
9.67e-10 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 59.38 E-value: 9.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPVI--DKKQENIDFeqlnAMVDKFIENGFTYFDTSYVYhnGKSEAALRKSVvERYPRERFTI--ATKFPTFA 81
Cdd:cd19144 16 LGFGAMGLSAFygPPKPDEERF----AVLDAAFELGCTFWDTADIY--GDSEELIGRWF-KQNPGKREKIflATKFGIEK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 82 IQTE---------DQVEEIFSQQLENLGTNYVDYYLLHLLNTKFyngsdsqggIVKKchLFEHMQKWKEEGKIRHIGFSf 152
Cdd:cd19144 89 NVETgeysvdgspEYVKKACETSLKRLGVDYIDLYYQHRVDGKT---------PIEK--TVAAMAELVQEGKIKHIGLS- 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507804023 153 HDSPEILDQILAEHPeVEFVQIIINYF--DWESYFIAS-KKCYEVirkhGKKVIVMEPVKGGFL 213
Cdd:cd19144 157 ECSAETLRRAHAVHP-IAAVQIEYSPFslDIERPEIGVlDTCREL----GVAIVAYSPLGRGFL 215
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
36-151 |
1.41e-09 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 58.41 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNGKSEAALRKSVveRYPRERFTIATK-FPTFAiqTEDQVEEIFSQQLENLGTNYVDYYLLHLlnt 114
Cdd:cd19138 39 IDLGMTLIDTAEMYGDGGSEELVGEAI--RGRRDKVFLVSKvLPSNA--SRQGTVRACERSLRRLGTDYLDLYLLHW--- 111
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 507804023 115 kfyngsdsQGGIvkkcHL---FEHMQKWKEEGKIRHIGFS 151
Cdd:cd19138 112 --------RGGV----PLaetVAAMEELKKEGKIRAWGVS 139
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
25-151 |
1.54e-09 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 58.73 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 25 FEQLnamvDKFIENGFTYFDTSYVY-------HNGKSEAALRKSVVERYPRERFTIATK-----------FPTFAIQTED 86
Cdd:cd19094 21 HEQL----DYAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKKKGNRDKVVLATKvagpgegitwpRGGGTRLDRE 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507804023 87 QVEEIFSQQLENLGTNYVDYYLLH-------LLNTKFYNGSDSQGGIVKKCHLFEHMQKWKEEGKIRHIGFS 151
Cdd:cd19094 97 NIREAVEGSLKRLGTDYIDLYQLHwpdrytpLFGGGYYTEPSEEEDSVSFEEQLEALGELVKAGKIRHIGLS 168
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
6-164 |
2.88e-09 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 57.20 E-value: 2.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPvidkkqeniDFEQLNAMVDKFIENGFTYFDTSYVYHNGKS-EAALRKSVVeryPRERFTIATKFpTFAIQT 84
Cdd:cd19133 12 LGFGVFQIP---------DPEECERAVLEAIKAGYRLIDTAAAYGNEEAvGRAIKKSGI---PREELFITTKL-WIQDAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 EDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSqggivkkchlfehMQKWKEEGKIRHIGFS-FHdsPEILDQIL 163
Cdd:cd19133 79 YEKAKKAFERSLKRLGLDYLDLYLIHQPFGDVYGAWRA-------------MEELYKEGKIRAIGVSnFY--PDRLVDLI 143
|
.
gi 507804023 164 A 164
Cdd:cd19133 144 L 144
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
12-164 |
3.78e-09 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 57.12 E-value: 3.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 12 RLPVIDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNgksEAALRKSVVE-----RYPRERFTIATKFPTFAIQTED 86
Cdd:cd19111 3 PMPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQN---EKAIGEALKWwlkngKLKREEVFITTKLPPVYLEFKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 87 qVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQGGIVKK--CHLFEHMQKWKEEGKIRHIGFSfHDSPEILDQILA 164
Cdd:cd19111 80 -TEKSLEKSLENLKLPYVDLYLIHHPCGFVNKKDKGERELASSdvTSVWRAMEALVSEGKVKSIGLS-NFNPRQINKILA 157
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
27-284 |
3.96e-09 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 57.16 E-value: 3.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 27 QLNAMVDKFIENGFTYFDTSYVYHNGKS-EAALRKSVVERYPRERFTIATK-FPTFaiqtEDQVEEIFSQQLENLGTNYV 104
Cdd:cd19121 26 EVKAAVAHALKIGYRHIDGALCYQNEDEvGEGIKEAIAGGVKREDLFVTTKlWSTY----HRRVELCLDRSLKSLGLDYV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 105 DYYLLH---LLN-----TKFYNGSDSQGGIVkkcHLFEHMQKWKE------EGKIRHIGFSFHDSPeILDQILAEHPEVE 170
Cdd:cd19121 102 DLYLVHwpvLLNpngnhDLFPTLPDGSRDLD---WDWNHVDTWKQmekvlkTGKTKAIGVSNYSIP-YLEELLKHATVVP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 171 FVQIIINYfdwesYFIASKKCYEVIRKHGKKVIVMEPV--KGGFLAQIPETAKQAlcsENPKFSPAGWALRFagSLDDEI 248
Cdd:cd19121 178 AVNQVENH-----PYLPQQELVDFCKEKGILIEAYSPLgsTGSPLISDEPVVEIA---KKHNVGPGTVLISY--QVARGA 247
|
250 260 270
....*....|....*....|....*....|....*.
gi 507804023 249 AVLSGMSTLDQMEDNIKTMKdfstLDEKEKNMLLQI 284
Cdd:cd19121 248 VVLPKSVTPDRIKSNLEIID----LDDEDMNKLNDI 279
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
24-160 |
6.72e-09 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 56.55 E-value: 6.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 24 DFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERYPRERFTIATKfptFAIQ-TEDQV-------EEIFSQ- 94
Cdd:cd19148 23 DEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATK---VGLEwDEGGEvvrnsspARIRKEv 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507804023 95 --QLENLGTNYVDYYLLHLLNTKfyngsdsqggiVKKCHLFEHMQKWKEEGKIRHIGFSFHdSPEILD 160
Cdd:cd19148 100 edSLRRLQTDYIDLYQVHWPDPL-----------VPIEETAEALKELLDEGKIRAIGVSNF-SPEQME 155
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
4-265 |
8.90e-09 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 55.69 E-value: 8.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 4 GKLGFGFMRLPVIDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKsVVERYPrERFTIATKfpTFAIQ 83
Cdd:cd19088 2 SRLGYGAMRLTGPGIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAE-ALHPYP-DDVVIATK--GGLVR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 84 TED--------------QVEEifsqQLENLGTNYVDYYLLHLLNTKfYNGSDSqggivkkchlFEHMQKWKEEGKIRHIG 149
Cdd:cd19088 78 TGPgwwgpdgspeylrqAVEA----SLRRLGLDRIDLYQLHRIDPK-VPFEEQ----------LGALAELQDEGLIRHIG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 150 FSFHDSPEIldQILAEHPEVEFVQiiiNyfdweSYFIASKKCYEVIR---KHGKKVIVMEPVKGGFLAQiPETAKQALcS 226
Cdd:cd19088 143 LSNVTVAQI--EEARAIVRIVSVQ---N-----RYNLANRDDEGVLDyceAAGIAFIPWFPLGGGDLAQ-PGGLLAEV-A 210
|
250 260 270
....*....|....*....|....*....|....*....
gi 507804023 227 ENPKFSPAGWALRFAGSLDDEIAVLSGMSTLDQMEDNIK 265
Cdd:cd19088 211 ARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLA 249
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
32-151 |
1.95e-08 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 55.20 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 32 VDKFIENGFTYFDTSYVYHNGKSEA-ALRKSVVeryPRERFTIATKFptfAIQTEDQVEEIFSQQLENLGTNYVDYYLLH 110
Cdd:cd19117 33 VEAALKAGYRHIDTAAIYGNEEEVGqGIKDSGV---PREEIFITTKL---WCTWHRRVEEALDQSLKKLGLDYVDLYLMH 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 507804023 111 L---LNTKFYNGSDSQGGIVKKcHL--------FEHMQKWKEEGKIRHIGFS 151
Cdd:cd19117 107 WpvpLDPDGNDFLFKKDDGTKD-HEpdwdfiktWELMQKLPATGKVKAIGVS 157
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
23-165 |
2.15e-08 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 54.69 E-value: 2.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 23 IDFEQLNAMVDKFIENGFTYFDTSYVYHN----GKseaALRKSVVeryPRERFTIATKFPTfAIQTEDQVEEIFSQQLEN 98
Cdd:cd19131 20 VSNDEAASAVREALEVGYRSIDTAAIYGNeegvGK---AIRASGV---PREELFITTKLWN-SDQGYDSTLRAFDESLRK 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507804023 99 LGTNYVDYYLLHLLntkfyngSDSQGGIVKKchlFEHMQKWKEEGKIRHIGFS-FhdSPEILDQILAE 165
Cdd:cd19131 93 LGLDYVDLYLIHWP-------VPAQDKYVET---WKALIELKKEGRVKSIGVSnF--TIEHLQRLIDE 148
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
26-289 |
2.17e-08 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 55.11 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHN----GKseaALRKSVVE-RYPRERFTIATKFPTFAIQTEDqVEEIFSQQLENLG 100
Cdd:cd19154 25 AEGITAVRTALKAGYRLIDTAFLYQNeeaiGE---ALAELLEEgVVKREDLFITTKLWTHEHAPED-VEEALRESLKKLQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 101 TNYVDYYLLHL-LNTK----FYNGSDSQGGIVKKChlfEHMQKWKE------EGKIRHIGFSFHDSPEIlDQILAehpeV 169
Cdd:cd19154 101 LEYVDLYLIHApAAFKddegESGTMENGMSIHDAV---DVEDVWRGmekvydEGLTKAIGVSNFNNDQI-QRILD----N 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 170 EFVQIIINYFDWESYFiASKKCYEVIRKHGKKVIV---------MEPVKGGFLAQIPETAKQALC---SENPKFSPAGWA 237
Cdd:cd19154 173 ARVKPHNNQVECHLYF-PQKELVEFCKKHNISVTSyatlgspgrANFTKSTGVSPAPNLLQDPIVkaiAEKHGKTPAQVL 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 507804023 238 LRFAgsLDDEIAVLSGMSTLDQMEDNIKTMkDFStLDEKEKNMLLQIAKEQK 289
Cdd:cd19154 252 LRYL--LQRGIAVIPKSATPSRIKENFNIF-DFS-LSEEDMATLEEIEKSLR 299
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
26-151 |
2.35e-08 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 54.50 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVErYPRERFTIATKFPTFAIQTEDQVEEiFSQQLENLGTNYVD 105
Cdd:cd19137 26 EEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKD-FPREDLFIVTKVWPTNLRYDDLLRS-LQNSLRRLDTDYID 103
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 507804023 106 YYLLHLLNTKfyngsdsqggiVKKCHLFEHMQKWKEEGKIRHIGFS 151
Cdd:cd19137 104 LYLIHWPNPN-----------IPLEETLSAMAEGVRQGLIRYIGVS 138
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
5-276 |
3.59e-08 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 54.15 E-value: 3.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVIDKKQenidfeqlnaMVDKFIENGFTYFDTSYVYhnGKSEAALRKSVVERYPRERFTIATKFPTfAIQT 84
Cdd:cd19130 12 QLGYGVFKVPPADTQR----------AVATALEVGYRHIDTAAIY--GNEEGVGAAIAASGIPRDELFVTTKLWN-DRHD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 EDQVEEIFSQQLENLGTNYVDYYLLHLlntkfynGSDSQGGIVkkcHLFEHMQKWKEEGKIRHIGFSFHdSPEILDQILA 164
Cdd:cd19130 79 GDEPAAAFAESLAKLGLDQVDLYLVHW-------PTPAAGNYV---HTWEAMIELRAAGRTRSIGVSNF-LPPHLERIVA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 165 EHPEVEFVqiiiNYFDWESYFiASKKCYEVIRKHGKKVIVMEPVKGGFLAQIPETAKQALCSENpkfSPAGWALRFagSL 244
Cdd:cd19130 148 ATGVVPAV----NQIELHPAY-QQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGK---TPAQIVLRW--HL 217
|
250 260 270
....*....|....*....|....*....|..
gi 507804023 245 DDEIAVLSGMSTLDQMEDNIKTMkDFSTLDEK 276
Cdd:cd19130 218 QKGHVVFPKSVRRERMEDNLDVF-DFDLTDTE 248
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
6-151 |
3.80e-08 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 53.79 E-value: 3.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLpvidKKQENIDfeqlnAMVDKFIENGFTYFDTSYVYHNgksEAALRKSVVERYP-----RERFTIATKF-PT 79
Cdd:cd19136 4 LGLGTFRL----RGEEEVR-----QAVDAALKAGYRLIDTASVYRN---EADIGKALRDLLPkyglsREDIFITSKLaPK 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507804023 80 FaiQTEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQGGIVKKCHLFEhMQKWKEEGKIRHIGFS 151
Cdd:cd19136 72 D--QGYEKARAACLGSLERLGTDYLDLYLIHWPGVQGLKPSDPRNAELRRESWRA-LEDLYKEGKLRAIGVS 140
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
30-156 |
4.48e-08 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 54.15 E-value: 4.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATKFpTFAIQTED-------------QVEeifsQQL 96
Cdd:cd19080 35 AMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGN--RDRIVLATKY-TMNRRPGDpnaggnhrknlrrSVE----ASL 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 97 ENLGTNYVDYYLLHllntkFYNGSDSQGGIVkkcHLFEHMQKwkeEGKIRHIGFSfhDSP 156
Cdd:cd19080 108 RRLQTDYIDLLYVH-----AWDFTTPVEEVM---RALDDLVR---AGKVLYVGIS--DTP 154
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
36-151 |
6.05e-08 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 53.44 E-value: 6.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNgksEAALRKSVVERY-----PRERFTIATKFPTFAIQTEdQVEEIFSQQLENLGTNYVDYYLLH 110
Cdd:cd19116 35 IEAGYRHIDTAYLYGN---EAEVGEAIREKIaegvvKREDLFITTKLWNSYHERE-QVEPALRESLKRLGLDYVDLYLIH 110
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 507804023 111 L-LNTKFYNGSDSQGGIVKKC----HLFEHMQKWKEEGKIRHIGFS 151
Cdd:cd19116 111 WpVAFKENNDSESNGDGSLSDidylETWRGMEDLVKLGLTRSIGVS 156
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
39-273 |
1.58e-07 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 52.15 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 39 GFTYFDTSYVYHNGKSEAALRKSVVE-RYPRERFTIATKF-----PTFAIqTEDQVEEIFSQQLENLGTNYVDYYLLHll 112
Cdd:cd19153 46 GINHFDTSPYYGAESSEAVLGKALAAlQVPRSSYTVATKVgryrdSEFDY-SAERVRASVATSLERLHTTYLDVVYLH-- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 113 NTKFYNGSDSQGGIVKKchlfehMQKWKEEGKIRHIGFSFHdsP-EILDQIlAEHPEVEFVQIIINY--FDWESYFIASK 189
Cdd:cd19153 123 DIEFVDYDTLVDEALPA------LRTLKDEGVIKRIGIAGY--PlDTLTRA-TRRCSPGSLDAVLSYchLTLQDARLESD 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 190 KCYEViRKHGKKVIVMEPVKGGFL------------AQIPETAKQAL--CSENpKFSPAGWALRFAGSLDDEIA-VLSGM 254
Cdd:cd19153 194 APGLV-RGAGPHVINASPLSMGLLtsqgpppwhpasGELRHYAAAADavCASV-EASLPDLALQYSLAAHAGVGtVLLGP 271
|
250
....*....|....*....
gi 507804023 255 STLDQMEDNIKTMKDFSTL 273
Cdd:cd19153 272 SSLAQLRSMLAAVDAVASL 290
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
36-264 |
1.71e-07 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 52.17 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNGKS-EAALRKSVVeryPRERFTIATKFPTfAIQTEDQVEEIFSQQLENLGTNYVDYYLLHLLNT 114
Cdd:cd19134 34 LEAGYRLIDTAAAYGNEAAvGRAIAASGI---PRGELFVTTKLAT-PDQGFTASQAACRASLERLGLDYVDLYLIHWPAG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 115 KFYNGSDSQGGIVKKchlfehmqkwKEEGKIRHIGFS-FHDspEILDQILaehpEVEFVQIIINYFDWESyFIASKKCYE 193
Cdd:cd19134 110 REGKYVDSWGGLMKL----------REEGLARSIGVSnFTA--EHLENLI----DLTFFTPAVNQIELHP-LLNQAELRK 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507804023 194 VIRKHGkkvIVME---PVKGGFLAQIPETAkqALCSENPKfSPAGWALRFagSLDDEIAVLSGMSTLDQMEDNI 264
Cdd:cd19134 173 VNAQHG---IVTQaysPLGVGRLLDNPAVT--AIAAAHGR-TPAQVLLRW--SLQLGNVVISRSSNPERIASNL 238
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
22-155 |
1.93e-07 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 51.95 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 22 NIDFEQLNAMVDKFIENGFTYFDTSYVY-------HNGKSEAALRKSVVERYPRERFTIATK-----------FPTFAIQ 83
Cdd:cd19752 13 RTDEETSFAILDRYVAAGGNFLDTANNYafwteggVGGESERLIGRWLKDRGNRDDVVIATKvgagprdpdggPESPEGL 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507804023 84 TEDQVEEIFSQQLENLGTNYVDYYLLHllntkfyngSDSQGgiVKKCHLFEHMQKWKEEGKIRHIGFSFHDS 155
Cdd:cd19752 93 SAETIEQEIDKSLRRLGTDYIDLYYAH---------VDDRD--TPLEETLEAFNELVKAGKVRAIGASNFAA 153
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
5-153 |
2.93e-07 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 51.36 E-value: 2.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPvidkkqeniDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSE-AALRKSVVeryPRERFTIATKFPTfAIQ 83
Cdd:cd19156 11 RLGLGVWRVQ---------DGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVgQGIRESGV---PREEVFVTTKLWN-SDQ 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507804023 84 TEDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSdsqggivkkchlFEHMQKWKEEGKIRHIGFS-FH 153
Cdd:cd19156 78 GYESTLAAFEESLEKLGLDYVDLYLIHWPVKGKFKDT------------WKAFEKLYKEKKVRAIGVSnFH 136
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
30-110 |
3.55e-07 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 51.42 E-value: 3.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATK--FPtfaiqTEDQVEEI----------FSQQLE 97
Cdd:cd19087 34 AIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGR--RDDIVLATKvfGP-----MGDDPNDRglsrrhirraVEASLR 106
|
90
....*....|...
gi 507804023 98 NLGTNYVDYYLLH 110
Cdd:cd19087 107 RLQTDYIDLYQMH 119
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
6-151 |
4.57e-07 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 51.08 E-value: 4.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRL-----PVIDKkQENIdfeqlnAMVDKFIENGFTYFDTSYVY---HN----GKSEAALRKSVVeryprerftI 73
Cdd:cd19078 7 IGLGCMGMshgygPPPDK-EEMI------ELIRKAVELGITFFDTAEVYgpyTNeelvGEALKPFRDQVV---------I 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 74 ATKF-PTFAIQTEDQVEEIFSQQ---------LENLGTNYVDYYLLHLLNTKfyngsdsqggiVKKCHLFEHMQKWKEEG 143
Cdd:cd19078 71 ATKFgFKIDGGKPGPLGLDSRPEhirkavegsLKRLQTDYIDLYYQHRVDPN-----------VPIEEVAGTMKELIKEG 139
|
....*...
gi 507804023 144 KIRHIGFS 151
Cdd:cd19078 140 KIRHWGLS 147
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
5-162 |
4.63e-07 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 50.60 E-value: 4.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFMRLPVIDKKQEnidfeqlnamVDKFIENGFTYFDTSYVYHNgksEAALRKSVVE-----RYPRERFTIATK-FP 78
Cdd:cd19128 3 RLGFGTYKITESESKEA----------VKNAIKAGYRHIDCAYYYGN---EAFIGIAFSEifkdgGVKREDLFITSKlWP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 79 TFaiQTEDQVEEIFSQQLENLGTNYVDYYLLH-----LLNTKFYNGSDSQGGIVKKCHL---FEHMQKWKEEGKIRHIGF 150
Cdd:cd19128 70 TM--HQPENVKEQLLITLQDLQLEYLDLFLIHwplafDMDTDGDPRDDNQIQSLSKKPLedtWRAMEQCVDEKLTKNIGV 147
|
170
....*....|..
gi 507804023 151 SFHDSPEILDQI 162
Cdd:cd19128 148 SNYSTKLLTDLL 159
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
30-265 |
5.32e-07 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 50.73 E-value: 5.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERypRERFTIATKF---------PTFAIQTEDQV----------EE 90
Cdd:cd19149 37 RTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR--RDKVVLATKCglrwdreggSFFFVRDGVTVyknlspesirEE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 91 IfSQQLENLGTNYVDYYLLHLlntkfyngSDSQGGIVKKchlFEHMQKWKEEGKIRHIGFSfHDSPEILDQILAeHPEVE 170
Cdd:cd19149 115 V-EQSLKRLGTDYIDLYQTHW--------QDVETPIEET---MEALEELKRQGKIRAIGAS-NVSVEQIKEYVK-AGQLD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 171 FVQiiinyfdwESYFIASKKCYEVI----RKHGKKVIVMEPVKGGFLA----QIPETAKQALCSENPKFSPA-------- 234
Cdd:cd19149 181 IIQ--------EKYSMLDRGIEKELlpycKKNNIAFQAYSPLEQGLLTgkitPDREFDAGDARSGIPWFSPEnrekvlal 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 507804023 235 --GW--------------ALRFAGSLDDEIAVLSGMSTLDQMEDNIK 265
Cdd:cd19149 253 leKWkplcekygctlaqlVIAWTLAQPGITSALCGARKPEQAEENAK 299
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
12-294 |
7.34e-07 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 50.25 E-value: 7.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 12 RLPVIDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYHN----GKS-EAALRKSVVERypRERFTIATKFPTFaiQTED 86
Cdd:cd19114 3 KMPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNeaevGRGiRKAIQEGLVKR--EDLFIVTKLWNNF--HGKD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 87 QVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQ---GGIVKKCHLFE-----------HMQKWKEEGKIRHIGFSF 152
Cdd:cd19114 79 HVREAFDRQLKDYGLDYIDLYLIHFPIPAAYVDPAENypfLWKDKELKKFPleqspmqecwrEMEKLVDAGLVRNIGIAN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 153 HDSPEILDQILAEHPEVEFVQIIINYFDWESYFI--ASKKCYEVI--RKHGKKVIVMEPVKGGFLAQIPETAKQALCSEN 228
Cdd:cd19114 159 FNVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIdwAKKQGIQITaySSFGNAVYTKVTKHLKHFTNLLEHPVVKKLADK 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507804023 229 PKFSPAGWALRFAgsLDDEIAVLSGMSTLDQMEDNIKTMkDFStLDEKEKNMLLQIAKEQKATGPE 294
Cdd:cd19114 239 HKRDTGQVLLRWA--VQRNITVIPKSVNVERMKTNLDIT-SYK-LDEEDMEALYELEANARFNDPV 300
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
24-287 |
9.41e-07 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 49.80 E-value: 9.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 24 DFEQLNAMVDKFIENGFTYFDTSYVY--HNGKSEAALRKSVVERYPRERFTIATK-FPTFaiqtEDQVEEIFSQQLENLG 100
Cdd:cd19119 25 DRAEVKEAVEAAIKEGYRHIDTAYAYetEDFVGEAIKRAIDDGSIKREELFITTKvWPTF----YDEVERSLDESLKALG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 101 TNYVDYYLLHlLNTKFYNGSDSQG---------GIVKKCHLFEHMQKWK------EEGKIRHIGFSfHDSPEILDQILAe 165
Cdd:cd19119 101 LDYVDLLLVH-WPVCFEKDSDDSGkpftpvnddGKTRYAASGDHITTYKqlekiyLDGRAKAIGVS-NYSIVYLERLIK- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 166 hpEVEFVQiIINYFDWESYFIASKKCyEVIRKHGKKVIVMEPV--KGGFLAQIPETAKQAlcsenPKFSPAGWALRFAGS 243
Cdd:cd19119 178 --ECKVVP-AVNQVELHPHLPQMDLR-DFCFKHGILVTAYSPLgsHGAPNLKNPLVKKIA-----EKYNVSTGDILISYH 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 507804023 244 LDDEIAVLSGMSTLDQMEDNIKtmkdFSTLDEKEKNMLLQIAKE 287
Cdd:cd19119 249 VRQGVIVLPKSLKPVRIVSNGK----IVSLTKEDLQKLDDIGEK 288
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
36-286 |
1.20e-06 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 49.57 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNGKS-----EAALRKSVVErypRERFTIATKFPTfAIQTEDQVEEIFSQQLENLGTNYVDYYLLH 110
Cdd:cd19110 27 IDAGYRHFDCAYLYHNESEvgagiREKIKEGVVR---REDLFIVSKLWC-TCHKKSLVKTACTRSLKALKLNYLDLYLIH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 111 lLNTKFYNGS-----DSQGGIVKKCHLF----EHMQKWKEEGKIRHIGFSFHDSpEILDQILaEHPEVEFvQIIINYFDW 181
Cdd:cd19110 103 -WPMGFKPGEpdlplDRSGMVIPSDTDFldtwEAMEDLVIEGLVKNIGVSNFNH-EQLERLL-NKPGLRV-KPVTNQIEC 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 182 ESYfIASKKCYEVIRKHGKKVIVMEPVKG--GFLAQIPETAKQALCSENPKfSPAGWALRFagSLDDEIAVLSGMSTLDQ 259
Cdd:cd19110 179 HPY-LTQKKLISFCQSRNVSVTAYRPLGGscEGVDLIDDPVIQRIAKKHGK-SPAQILIRF--QIQRNVIVIPKSVTPSR 254
|
250 260
....*....|....*....|....*..
gi 507804023 260 MEDNIKTMkDFStLDEKEKNMLLQIAK 286
Cdd:cd19110 255 IKENIQVF-DFE-LTEHDMDNLLSLDR 279
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
5-296 |
3.56e-06 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 48.25 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 5 KLGFGFmRLPVIDKKQENIDFEQLNAMVDKFIENGFTYFDTSYVYhngKSEAALRKSVVERY-----PRERFTIATKfpt 79
Cdd:cd19112 4 TLNSGH-KMPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADY---KNEKEVGEALAEAFktglvKREDLFITTK--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 80 faIQTEDQ--VEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQGGIVKKCHLFE------------HMQKWKEEGKI 145
Cdd:cd19112 77 --LWNSDHghVIEACKDSLKKLQLDYLDLYLVHFPVATKHTGVGTTGSALGEDGVLDidvtislettwhAMEKLVSAGLV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 146 RHIGFSFHDspeildqILAEHPEVEFVQI--IINYFDWESYFIAS---KKCyeviRKHGKKVIVMEPVKGGflAQIPETA 220
Cdd:cd19112 155 RSIGISNYD-------IFLTRDCLAYSKIkpAVNQIETHPYFQRDslvKFC----QKHGISVTAHTPLGGA--AANAEWF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 221 KQALCSENPKF---------SPAGWALRFagSLDDEIAVLSGMSTLDQMEDNIKTMkDFStLDEKEKNMLLQIAKEQKAT 291
Cdd:cd19112 222 GSVSPLDDPVLkdlakkygkSAAQIVLRW--GIQRNTAVIPKSSKPERLKENIDVF-DFQ-LSKEDMKLIKSLDRKYRTN 297
|
....*
gi 507804023 292 GPEKT 296
Cdd:cd19112 298 QPAKF 302
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
26-160 |
1.24e-05 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 46.58 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHNGKSE----AALRksvveRYPRERFTIATK-------------FPTFAIQ--TED 86
Cdd:cd19162 19 DEAAATLDAAWDAGIRYFDTAPLYGLGLSErrlgAALA-----RHPRAEYVVSTKvgrllepgaagrpAGADRRFdfSAD 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507804023 87 QVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSDSQggivkkchlFEHMQKWKEEGKIRHIGFSFHDSPEILD 160
Cdd:cd19162 94 GIRRSIEASLERLGLDRLDLVFLHDPDRHLLQALTDA---------FPALEELRAEGVVGAIGVGVTDWAALLR 158
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
27-174 |
1.97e-05 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 45.86 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 27 QLNAMVDKFIENGFTYFDTSYVYHNgKSE--AALRKSVVER--YPRERFTIATKFPTFAIQTEDqVEEIFSQQLENLGTN 102
Cdd:cd19118 21 EVGAAVKIALKAGYRHLDLAKVYQN-QHEvgQALKELLKEEpgVKREDLFITSKLWNNSHRPEY-VEPALDDTLKELGLD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 103 YVDYYLLH------------LLNTKFYNGS----DSQggiVKKCHLFEHMQKWKEEGKIRHIGFS-FhdSPEILDQILAE 165
Cdd:cd19118 99 YLDLYLIHwpvafkptgdlnPLTAVPTNGGevdlDLS---VSLVDTWKAMVELKKTGKVKSIGVSnF--SIDHLQAIIEE 173
|
170
....*....|
gi 507804023 166 HPEVEFV-QI 174
Cdd:cd19118 174 TGVVPAVnQI 183
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
6-153 |
2.48e-05 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 45.46 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPvidkkqeniDFEQLNAMVDKFIENGFTYFDTSYVYHNgksEAALRKSVVER-YPRERFTIATKFPTfAIQT 84
Cdd:cd19157 13 LGLGVFKVE---------EGSEVVNAVKTALKNGYRSIDTAAIYGN---EEGVGKGIKESgIPREELFITSKVWN-ADQG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 EDQVEEIFSQQLENLGTNYVDYYLLHLLNTKFYNGSdsqggivkkchlFEHMQKWKEEGKIRHIGFS-FH 153
Cdd:cd19157 80 YDSTLKAFEASLERLGLDYLDLYLIHWPVKGKYKET------------WKALEKLYKDGRVRAIGVSnFQ 137
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-161 |
2.90e-05 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 45.28 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 28 LNAMvDKFIENGFTYFDTSYVYhnGKSE----AALRKSVVERYPRERFTIATKF---PTFAIQTEDQVEEIFSQQLENLG 100
Cdd:cd19101 26 VRAM-AAYVDAGLTTFDCADIY--GPAEeligEFRKRLRRERDAADDVQIHTKWvpdPGELTMTRAYVEAAIDRSLKRLG 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507804023 101 TNYVDyyllhLLntKFYNGSDSQGGIVkkcHLFEHMQKWKEEGKIRHIGFSFHDSP---EILDQ 161
Cdd:cd19101 103 VDRLD-----LV--QFHWWDYSDPGYL---DAAKHLAELQEEGKIRHLGLTNFDTErlrEILDA 156
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
27-151 |
3.90e-05 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 45.10 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 27 QLNAMVDKFIENGFTYFDTSYVYHNGKS-----EAALRKSVVERypRERFTIATKFPTFaiQTEDQVEEIFSQQLENLGT 101
Cdd:cd19107 18 QVTEAVKVAIDAGYRHIDCAYVYQNENEvgeaiQEKIKEQVVKR--EDLFIVSKLWCTF--HEKGLVKGACQKTLSDLKL 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 507804023 102 NYVDYYLLHlLNTKFYNGS-----DSQGGIVKKCHLF----EHMQKWKEEGKIRHIGFS 151
Cdd:cd19107 94 DYLDLYLIH-WPTGFKPGKelfplDESGNVIPSDTTFldtwEAMEELVDEGLVKAIGVS 151
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
30-110 |
4.55e-05 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 45.11 E-value: 4.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVERYPRERFTIATKFPTFAIQTEDQVEEIFSQ-------------QL 96
Cdd:cd19146 39 KLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDEMVLATKYTTGYRRGGPIKIKSNYQgnhakslrlsveaSL 118
|
90
....*....|....
gi 507804023 97 ENLGTNYVDYYLLH 110
Cdd:cd19146 119 KKLQTSYIDILYVH 132
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
36-151 |
8.19e-05 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 44.14 E-value: 8.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNGKSEA-ALRKSVVE-RYPRERFTIATK-FPTFaiQTEDQVEEIFSQQLENLGTNYVDYYLLH-- 110
Cdd:cd19108 37 IDAGFRHIDSAYLYQNEEEVGqAIRSKIADgTVKREDIFYTSKlWCTF--HRPELVRPALEKSLKKLQLDYVDLYLIHfp 114
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 507804023 111 --LLNTKFYNGSDSQGGI----VKKCHLFEHMQKWKEEGKIRHIGFS 151
Cdd:cd19108 115 vaLKPGEELFPKDENGKLifdtVDLCATWEAMEKCKDAGLAKSIGVS 161
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
6-267 |
9.64e-05 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 43.50 E-value: 9.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLpvidKKQENIDfEQLNAMvdkfiENGFTYFDTSYVYHNGKS-EAALRKSVVeryPRERFTIATKFPTFAIQT 84
Cdd:cd19139 4 FGLGTFRL----KDDVVID-SVRTAL-----ELGYRHIDTAQIYDNEAAvGQAIAESGV---PRDELFITTKIWIDNLSK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 eDQVEEIFSQQLENLGTNYVDYYLLHLlntkfyngsDSQGGIVKKCHLFEHMQKWKEEGKIRHIGFSFHDSPeILDQILA 164
Cdd:cd19139 71 -DKLLPSLEESLEKLRTDYVDLTLIHW---------PSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIA-LLDEAIA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 165 ehpEVEFVQIIINYFDWESYFiASKKCYEVIRKHGKKVIVMEPVKGGFLAQIPETAKQAlcsENPKFSPAGWALRFAGSL 244
Cdd:cd19139 140 ---VVGAGAIATNQIELSPYL-QNRKLVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIA---ERHGATPAQIALAWAMAR 212
|
250 260
....*....|....*....|...
gi 507804023 245 DdeIAVLSGMSTLDQMEDNIKTM 267
Cdd:cd19139 213 G--YAVIPSSTKREHLRSNLLAL 233
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
23-110 |
1.16e-04 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 43.61 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 23 IDFEQLNAMVDKFIENGFTYFDTSYVYHNGKSEAALRKSVVER-YPRERFTIATKF-----PTFAIQTEDQVEEIFSQQL 96
Cdd:cd19142 28 ISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKgWKRSSYIVSTKIywsygSEERGLSRKHIIESVRASL 107
|
90
....*....|....
gi 507804023 97 ENLGTNYVDYYLLH 110
Cdd:cd19142 108 RRLQLDYIDIVIIH 121
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
6-164 |
1.62e-04 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 42.78 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 6 LGFGFMRLPVidkkqenidfEQLNAMVDKFIENGFTYFDTSYVYHNGKSEA-ALRKSVVeryPRERFTIATKFpTFAIQT 84
Cdd:cd19127 12 LGLGVFQTPP----------EETADAVATALADGYRLIDTAAAYGNEREVGeGIRRSGV---DRSDIFVTTKL-WISDYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 85 EDQVEEIFSQQLENLGTNYVDYYLLHLlntkfyngsdsqggIVKkcHLFEH-MQKWK------EEGKIRHIGFSFHdSPE 157
Cdd:cd19127 78 YDKALRGFDASLRRLGLDYVDLYLLHW--------------PVP--NDFDRtIQAYKalekllAEGRVRAIGVSNF-TPE 140
|
....*..
gi 507804023 158 ILDQILA 164
Cdd:cd19127 141 HLERLID 147
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
27-164 |
1.70e-04 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 43.14 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 27 QLNAMVDKFIENGFTYFDTSYVYHNGKS-EAALRKSVVERY--PRERFTIATKFPTFAIQTEDqVEEIFSQQLENLGTNY 103
Cdd:cd19106 21 QVKAAVKYALDAGYRHIDCAAVYGNEQEvGEALKEKVGPGKavPREDLFVTSKLWNTKHHPED-VEPALRKTLKDLQLDY 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 104 VDYYLLHlLNTKFYNG-----SDSQGGI----VKKCHLFEHMQKWKEEGKIRHIGFSFHDSPEIlDQILA 164
Cdd:cd19106 100 LDLYLIH-WPYAFERGdnpfpKNPDGTIrydsTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQI-DDILS 167
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
30-151 |
2.60e-04 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 42.61 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 30 AMVDKFIENGFTYFDTSYVYHN-GKSEAALRKSVVER--YPRERFTIATKFPTFAIQTEDqVEEIFSQQLENLGTNYVDY 106
Cdd:cd19122 28 AAVTKALDVGYRHLDCAWFYLNeDEVGDAVRDFLKENpsVKREDLFICTKVWNHLHEPED-VKWSIDNSLKNLKLDYIDL 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 507804023 107 YLLHLLNTKFYNGSDS-----QGGIVKKCHLFEH-------MQKWKEEGKIRHIGFS 151
Cdd:cd19122 107 FLVHWPIAAEKNDQRSpklgpDGKYVILKDLTENpeptwraMEEIYESGKAKAIGVS 163
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
26-165 |
3.14e-04 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 41.98 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHN----GKseaALRKSVVeryPRERFTIATKfptfaIQTEDQ--VEEIFSQQLENL 99
Cdd:PRK11565 28 EEVITAIHKALEVGYRSIDTAAIYKNeegvGK---ALKEASV---AREELFITTK-----LWNDDHkrPREALEESLKKL 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507804023 100 GTNYVDYYLLHLlntkfynGSDSQGGIVkkcHLFEHMQKWKEEGKIRHIGFS-FHdsPEILDQILAE 165
Cdd:PRK11565 97 QLDYVDLYLMHW-------PVPAIDHYV---EAWKGMIELQKEGLIKSIGVCnFQ--IHHLQRLIDE 151
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
29-165 |
1.06e-03 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 40.39 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 29 NAMVDKFIENGFTYFDTSYVYHNgksEAALRKSVVER-YPRERFTIATK-FPTfaiqtE---DQVEEIFSQQLENLGTNY 103
Cdd:cd19135 29 EAVVYALKECGYRHIDTAKRYGC---EELLGKAIKESgVPREDLFLTTKlWPS-----DygyESTKQAFEASLKRLGVDY 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507804023 104 VDYYLLHLlntkfyngSDSQGGIVKKCHLFEhmQKWK------EEGKIRHIGFS-FhdSPEILDQILAE 165
Cdd:cd19135 101 LDLYLLHW--------PDCPSSGKNVKETRA--ETWRaleelyDEGLCRAIGVSnF--LIEHLEQLLED 157
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
26-110 |
2.01e-03 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 39.56 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 26 EQLNAMVDKFIENGFTYFDTSYVYHngkSEAALRKSVVER------YPRERFTIATK-FPTFAiqTEDQVEEIFSQQLEN 98
Cdd:cd19124 20 EDIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAEAlrlglvKSRDELFVTSKlWCSDA--HPDLVLPALKKSLRN 94
|
90
....*....|..
gi 507804023 99 LGTNYVDYYLLH 110
Cdd:cd19124 95 LQLEYVDLYLIH 106
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
36-151 |
2.70e-03 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 39.36 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507804023 36 IENGFTYFDTSYVYHNGKSEAALRKSVVE--RYPRERFTIATKFPTFAIQTEdQVEEIFSQQLENLGTNYVDYYLLHlln 113
Cdd:cd19129 29 LEAGFRHFDCAERYRNEAEVGEAMQEVFKagKIRREDLFVTTKLWNTNHRPE-RVKPAFEASLKRLQLDYLDLYLIH--- 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 507804023 114 TKF-YNGSDSQ------GGI-----VKKCHLFEHMQKWKEEGKIRHIGFS 151
Cdd:cd19129 105 TPFaFQPGDEQdprdanGNViyddgVTLLDTWRAMERLVDEGRCKAIGLS 154
|
|
| |
