|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
14-422 |
2.42e-159 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 456.22 E-value: 2.42e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 14 RQVLTGTLVGTTIEFYDFLIYAQAAAIVLAPHFiepAAQSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMIL 93
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLF---FPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 94 VFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLA 173
Cdd:cd17369 78 VLTLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 174 TGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSAPLPELFRNHWGKVIQGALIF 253
Cdd:cd17369 158 TGVFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 254 AAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQ 333
Cdd:cd17369 238 LAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 334 GPFLYIMTVAVLTLPL--ALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYLMA 411
Cdd:cd17369 318 GSTWLIVLAAVVVLGVlhGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLAA 397
|
410
....*....|.
gi 512048596 412 MAIPALIALFL 422
Cdd:cd17369 398 LAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
23-417 |
5.23e-120 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 355.43 E-value: 5.23e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 23 GTTIEFYDFLIYAQAAAIVlAPHFIEPaaQSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGA 102
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLV-FHTFFPP--SGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 103 ATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMA 182
Cdd:TIGR00883 78 GTLLIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 183 IVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSAPLPELFRNHWGKVIQGALIFAAQQATGYL 262
Cdd:TIGR00883 158 LLGDDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 263 VIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMI--WEAVMWsILDQGPFlYIM 340
Cdd:TIGR00883 238 ITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALlaVPLLMA-LLDSGSF-TLF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 512048596 341 TVAVLTLPLAL--TFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPAL 417
Cdd:TIGR00883 316 FFLVLGMALIGgmYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-426 |
8.19e-92 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 284.70 E-value: 8.19e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 1 MTTSIIANDP-------KQRRQVLTGTLVGTTIEFYDFLIYAQAAAIVLAPHFIepaAQSNPQVAQVLAWATLGISFLFR 73
Cdd:PRK09952 1 MDSTLISTRPdegtlslSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFF---PQVSPAMGTLAAFATFGVGFLFR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 74 PLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKE 153
Cdd:PRK09952 78 PLGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 154 KRGLYGAFPQAGVPLGLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSA 233
Cdd:PRK09952 158 KKAFYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 234 PLP--ELFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWT-GTLVAGI-CWTIFMFiagAW-SDRIG 308
Cdd:PRK09952 238 RIPviEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNiGLLVGGLsCLTIPCF---AWlADRFG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 309 RAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLPLA--LTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGA 386
Cdd:PRK09952 315 RRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAhdMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGG 394
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 512048596 387 FAPMIA-QMIMDATGNPFYISVYLMA-MAIPALIALFLLPKG 426
Cdd:PRK09952 395 FTPFIAaALVTYFGGSWHSVAIYLLAgCLISAMTALLMKDNQ 436
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
18-425 |
1.64e-78 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 248.43 E-value: 1.64e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 18 TGTLVGTTIEFYDFLIYAQAAAIVLAPHFiePAAqsNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTL 97
Cdd:cd17366 2 KAAALGNAMEWFDFGVYGYLAVTIGKVFF--PGG--DPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 98 IGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTM 177
Cdd:cd17366 78 ILMAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 178 LIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSvdespvfqamqtesaersaplpelfrnhwgkVIQGALIFAAQQ 257
Cdd:cd17366 158 TLLTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRP-------------------------------LLICIGLVLVFN 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 258 ATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGPFL 337
Cdd:cd17366 207 VTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 338 YIMT-VAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPA 416
Cdd:cd17366 287 AIFIgLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVG 366
|
....*....
gi 512048596 417 LIALFLLPK 425
Cdd:cd17366 367 LVAVLFLTE 375
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
17-425 |
9.70e-73 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 234.50 E-value: 9.70e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 17 LTGTLVGTTIEFYDFLIYAqAAAIVLAPHFIepaAQSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFT 96
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYA-AFALYFAPQFF---PSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 97 LIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGT 176
Cdd:cd17367 77 VSLMAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 177 MLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSAPLPELfRNHWGKVIQGALIFAAQ 256
Cdd:cd17367 157 LLVLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLREL-RRHPRELLLVVGLTAGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 257 QATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGPF 336
Cdd:cd17367 236 TLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 337 LYIMTVAVLTLPLALTFGP--QPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYIsVYLMAMAI 414
Cdd:cd17367 316 PYTAFALVLVGLVFLSGYTsiNAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFF-WYVAGLIA 394
|
410
....*....|.
gi 512048596 415 PALIALFLLPK 425
Cdd:cd17367 395 ISLVVYLRMPE 405
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
9-418 |
4.07e-69 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 227.67 E-value: 4.07e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 9 DPKQRRQVLTGTLVGTTIEFYDFLIYAqAAAIVLAPHFIEPAaqsNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYG 88
Cdd:PRK10642 10 DDGKLRKAITAASLGNAMEWFDFGVYG-FVAYALGKVFFPGA---DPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 89 RKMILVFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPL 168
Cdd:PRK10642 86 RQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 169 GLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAM--QTESAERSA-------PLPELF 239
Cdd:PRK10642 166 GFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHvdKLEQGDREGlqdgpkvSFKEIA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 240 RNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATvawTGTLVAgICWTIFMF----IAGAWSDRIGRAKTFII 315
Cdd:PRK10642 246 TKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSED---HGVLII-IAIMIGMLfvqpVMGLLSDRFGRRPFVIL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 316 GYVVIMIWEAVMWSILDQGpFLYIMTVAVLTLPLALTF--GPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGaFAPMIAQ 393
Cdd:PRK10642 322 GSVALFVLAIPAFILINSN-VIGLIFAGLLMLAVILNCftGVMASTLPAMFPTHIRYSALAAAFNISVLVAG-LTPTLAA 399
|
410 420
....*....|....*....|....*
gi 512048596 394 MIMDATGNPFYISVYLMAMAIPALI 418
Cdd:PRK10642 400 WLVESTQNLMMPAYYLMVVAVIGLI 424
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
23-427 |
4.09e-69 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 224.95 E-value: 4.09e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 23 GTTIEFYDFLIYAQAAAIVLAPHFiePAAQSNpqVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGA 102
Cdd:cd17368 7 GNALEFFDFGVYGFFAVYIGRLFF--PSGSEF--ASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 103 ATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMA 182
Cdd:cd17368 83 GTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 183 IVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSapLPELFRNHWGKVIQGALIFAAQQATGYL 262
Cdd:cd17368 163 TLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE--LFALLANNRRIILLGMLLVAGSTVTFYF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 263 VIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYV--VIMIWEAVMWSILDQGPFLYIM 340
Cdd:cd17368 241 TTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLaaLVTLYPVFAWLTAAPSFGRLLL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 341 TVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPALIAL 420
Cdd:cd17368 321 VLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLAT 400
|
....*..
gi 512048596 421 FLLPKGL 427
Cdd:cd17368 401 LMLRETA 407
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
23-430 |
1.08e-53 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 185.15 E-value: 1.08e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 23 GTTIEFYDFLIYAQAAAIVLAPHFiePAaqSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGA 102
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFF--PA--GNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 103 ATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMA 182
Cdd:PRK15075 99 GTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 183 IVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERsaplpELFR---NHWGKVIQGALIFAAQQAT 259
Cdd:PRK15075 179 WLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMR-----EIFRslaANWRIVLAGMLMVAMTTVS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 260 GYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRaKTFIIGYVVIMI---WEAVMWsiLDQGPF 336
Cdd:PRK15075 254 FYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGR-RPVLIAFTVLAIltaYPALSW--LVAAPS 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 337 LYIMTVAVLTLPL--ALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYLMAMAI 414
Cdd:PRK15075 331 FARMLAVELWLSFlyGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAAPGYWLSFAAV 410
|
410
....*....|....*.
gi 512048596 415 PALIALFLLPKGLEDR 430
Cdd:PRK15075 411 CGLIATLVLYRRRGAR 426
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-421 |
2.50e-50 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 174.33 E-value: 2.50e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 17 LTGTLVGTTIEFYDFLIYAQAAAIVlaphfiepAAQSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFT 96
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVL--------AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 97 LIGMGAATFCIGLLPTyesigiaaPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGT 176
Cdd:cd17316 73 LLLFGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 177 MLIVMAIVGEeaymDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAER-SAPLPELFRNHWGKVIQGALIFAA 255
Cdd:cd17316 145 ASLLIPLLSG----DWGWRILFLIGALPALLALLLRRRTLLLILLWFFISFGYYGlTTFLPTYLQTVLGLSPATSSLYLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 256 QQATGYLVIAffgayaqktlgypatvawtgtlvagicwtifmFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGP 335
Cdd:cd17316 221 LISLGALVGA--------------------------------LIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 336 FLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAvLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIP 415
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGR-LGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
....*.
gi 512048596 416 ALIALF 421
Cdd:cd17316 348 ALIVAL 353
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
1-426 |
1.31e-43 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 158.43 E-value: 1.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 1 MTTSIIANDP-------KQRRQVLTGTLVGTTIEFYDFLIYAQAAaiVLAPHFIEPAAQSNPQVAQVLAWATLGisFLFR 73
Cdd:PRK10406 1 MAESTVTADSkltssdtRRRIWAIVGASSGNLVEWFDFYVYSFCS--LYFAHIFFPSGNTTTQLLQTAGVFAAG--FLMR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 74 PLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKE 153
Cdd:PRK10406 77 PIGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 154 KRGLYGAFPQAGVPLGLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESpvfQAMQTESAERSA 233
Cdd:PRK10406 157 RKGFYASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET---SQQETRALKEAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 234 PLPELFRNHwgKVIQGALIFAaqqATGYLVIAFFGAYAQK----TLGYPATVAwTGTLVAGICwtIFMFIA---GAWSDR 306
Cdd:PRK10406 234 SLKGLWRNR--RAFIMVLGFT---AAGSLCFYTFTTYMQKylvnTAGMHANVA-SGIMTAALF--VFMLIQpliGALSDK 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 307 IGRAKTFIIGYVVIMIWEAVMWSILDQ--GPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLG 384
Cdd:PRK10406 306 IGRRTSMLCFGSLAALFTVPILSALQNvsSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALF 385
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 512048596 385 GAFAPMIAQMIMDA-TGNPFYISVYLMAmAIPALIALFLLPKG 426
Cdd:PRK10406 386 GGSAEYVALSLKSIgMETAFFWYVTLMA-VVAFLVSLMLHRKG 427
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-425 |
2.03e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 137.70 E-value: 2.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 11 KQRRQVLTGTLVGTTIEFYDFLIYAqaaaiVLAPHFIEPAAQSNPQVAQVLAwatlgISFLFRPLGAIVAGHIGDRYGRK 90
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWS-----VLAPPLAEEFGLSAAQLGLLFA-----IPVLVGALLRIPLGFLVDRFGPR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 91 MILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGL 170
Cdd:COG2223 71 RVLLIGLLLLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 171 TLATGTMLIVMAIvgeeaymdWGWRVPFLL-SFILVLIGYMIRRSVDESPVFQAmqTESAERSAPLPELFRNhwGKVIQG 249
Cdd:COG2223 143 AVAAFLAPLLIAA--------FGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAA--AAAKASLRDQLEALRD--PRFWLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 250 ALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWeAVMWS 329
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG-LLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 330 ILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAvLGGAFAPMIAQMIMDATGNPFYISVYL 409
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLFGALLDATGSYTAAFLVF 368
|
410
....*....|....*.
gi 512048596 410 MAMAIPALIALFLLPK 425
Cdd:COG2223 369 AVLALVALVLTLLLYR 384
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
15-424 |
1.09e-33 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 131.63 E-value: 1.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 15 QVLTGTLVGttiefYDFLIYAqAAAIVLAPHFIEPAAQSNPQVAQVLAWATLGISFLF--RPLGAIVAGHIGDRYGRKMI 92
Cdd:pfam00083 5 AALGGFLFG-----YDTGVIG-AFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSvgCFIGSLFAGKLGDRFGRKKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 93 LVFTLIGMGAATFCIGLlptyeSIGIAAPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTL 172
Cdd:pfam00083 79 LLIANVLFVIGAVLQGA-----AKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 173 ATGTMLIVMAIVGEeaymdWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQT-------------------------- 226
Cdd:pfam00083 154 AYIFGLGLNKTSNS-----DGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGrleearevlaklrgvpdvdreldeik 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 227 -----ESAERSAPLPELFR--NHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGtlVAGICWTIFMFI 299
Cdd:pfam00083 229 dsleaGQEAEKASWKELFStkTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTI--IVGVVNFVFTFI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 300 AGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGP-------FLYIMTVAVLTLPLALTFGPQPAMY-SEMFPAEVRYS 371
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLGAAGMAICFVILGIVALLGVsksdwagIVAIVFIALFIAFFAMGWGPVPWVIvSELFPLSVRSK 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 512048596 372 GASIAYAIGaVLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:pfam00083 387 AMALATAAN-WLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVP 438
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
76-424 |
3.60e-32 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 126.26 E-value: 3.60e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 76 GAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESigiaapilLVLLRVFQGISAGGEWGGAALMSVEYAPKEKR 155
Cdd:cd17371 50 GGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 156 GLYGAFPQAGVPLGLTLATGTMLIVMAIVGEEaymdWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTE--SAERSA 233
Cdd:cd17371 122 GKALGYVQSGWAVGWLLATLLAALLFPLLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAArrHFADRP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 234 PLPELF-RNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAwTGTLVAGICWTIFMFIAGAW-SDRIGRAK 311
Cdd:cd17371 198 SLRELFsPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGS-AGYLVVTILGGFLGYLAGGFlADRIGRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 312 TFIIGYVVIMIWEAVMwSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAvLGGAFAPMI 391
Cdd:cd17371 277 NFALFALGSAISILLY-FFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGR-IIGALFPFL 354
|
330 340 350
....*....|....*....|....*....|...
gi 512048596 392 AQMIMDATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:cd17371 355 VGFLATSGSLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-425 |
2.22e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 117.66 E-value: 2.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 11 KQRRQVLTGTLVGTTIEFYDFLIYAQAAAIVLAPHFIEPAAQSnpqvaqvlawATLGISFLFRPLGAIVAGHIGDRYGRK 90
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLG----------LLASAFFLGYALGQIPAGLLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 91 MILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGL 170
Cdd:COG2271 76 RVLAIGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 171 TLATGTMLIVMAIvgeeaymdWGWRVPFLLSFILVLIGYMIRrsvdespvfqamqtesaersaplpelfrnhwgkVIQGA 250
Cdd:COG2271 148 ALAPPLLGWLLAA--------FGWRAAFLILGLPGLLLALLR---------------------------------FWLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 251 LIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSI 330
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 331 LDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGaVLGGAFAPMIAQMIMDATGNPFYISVYLM 410
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG-FLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|....*
gi 512048596 411 AMAIPALIALFLLPK 425
Cdd:COG2271 346 LALLAALLALLLLRE 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-386 |
1.13e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.76 E-value: 1.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 9 DPKQRRQVLTGTLVGTTIEFYDFLIYAqaaaiVLAPHFIEPAAQSNPQVAQVLAwatlgISFLFRPLGAIVAGHIGDRYG 88
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVL-----PALPLIAADLGASPAQAGLVVT-----AYLLGAALGAPLAGRLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 89 RKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPL 168
Cdd:COG2814 74 RRRVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 169 GLTLAtgtmlivmAIVGEEAYMDWGWRVPFLLSFILVLIG-YMIRRSVDESPVFQAmqtesAERSAPLPELFRNHWgkVI 247
Cdd:COG2814 146 GPALG--------PLLGGLLADLFGWRWVFLVNAVLALLAlLLLLRLLPESRPAAR-----ARLRGSLRELLRRPR--LL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 248 QGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVM 327
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 512048596 328 WsiLDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGA 386
Cdd:COG2814 291 A--LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-322 |
1.79e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 105.28 E-value: 1.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 3 TSIIANDPKQRRQVLTGTLVGTTIEFYDFLIYAQAAAIvlaphfIEPAAQSNPQVAQVLawatLGISFLFRPLGAIVAGH 82
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPS------IAADLGASSAQLGWI----VSAYLLGRAIGLLLFGR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 83 IGDRYGRKMILVFTLIGMGAATFCIGLLPTyesigiaaPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFP 162
Cdd:COG0477 72 LGDRYGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLW 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 163 QAGVPLGLTLATGTMLIVMAIvgeeaymdWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSAPLPELFRNH 242
Cdd:COG0477 144 GAAIGLGLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALAL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 243 WGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMI 322
Cdd:COG0477 216 LALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
66-421 |
2.51e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.81 E-value: 2.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 66 LGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALM 145
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 146 SVEYAPKEKRGLYGAFPQAGVPLGltlatgtmLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQ 225
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLG--------FLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 226 TESAERSAPLPELFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSD 305
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 306 RIGRAKTFIIGYVVIMIweAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVR---YSGASIAYAIGAV 382
Cdd:cd17325 261 RIGRKPLILIGLLLSAV--ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRgtaMGLFNTAFSLGMV 338
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 512048596 383 LGgafaPMIAQMIMDATG--NPFYISVYLMAMAIPALIALF 421
Cdd:cd17325 339 LG----PLLGGFLYDAFGfaTPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
66-389 |
1.67e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.32 E-value: 1.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 66 LGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALM 145
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 146 SVEYAPKEKRGLYGAFPQAGVPLGLtlatgtmlIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVfQAMQ 225
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGA--------ALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE-SKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 226 TESAERSAPLPELFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSD 305
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 306 RIGRAKTFIIGYVVIMIWE-AVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAvLG 384
Cdd:pfam07690 261 RLGRRRRLLLALLLLILAAlGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS-LG 339
|
....*
gi 512048596 385 GAFAP 389
Cdd:pfam07690 340 GALGP 344
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
76-424 |
2.37e-16 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 80.85 E-value: 2.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 76 GAIVAGHIGDRYGRKMilvfTLIGMGAATFCIGLLPTYESIGIAAPILLVLlRVFQGISaggeWGGAALMSVEY----AP 151
Cdd:TIGR00879 87 GALFAGWLSDRFGRKK----SLLIIALLFVIGAILMGLAAFALSVEMLIVG-RVLLGIG----VGIASALVPMYlseiAP 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 152 KEKRGLYGAFPQAGVPLGLTLATGTMliVMAIVgeeAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQ--TESA 229
Cdd:TIGR00879 158 KALRGALTSLYQLAITFGILVAYGFG--SGKVS---LNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKgrVEEA 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 230 ERS------------------------------------APLPELFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQK 273
Cdd:TIGR00879 233 RKSlarlrgtsgedkelldelelidikrsiekrsvqpswGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFE 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 274 TLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVM--------WSILDQGPFLYIMTVAVL 345
Cdd:TIGR00879 313 NAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLgilgasfvTGSSKSSGNVAIVFILLF 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 346 TLPLALTFGPQPAMY-SEMFPAEVRYSGASIAYA---IGAVLGGAFAPmiaqMIMDATGNPFYISVYLMAMAIPALIALF 421
Cdd:TIGR00879 393 IAFFAMGWGPVPWVIvSEIFPLSLRPKGISIAVAanwLANFIVGFLFP----TMLESIGVGGVFIFFGGLNVLGLIFVYF 468
|
...
gi 512048596 422 LLP 424
Cdd:TIGR00879 469 FLP 471
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
75-421 |
3.46e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.78 E-value: 3.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd06174 46 LLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLAtgtMLIVMAIVgeeAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAERSAP 234
Cdd:cd06174 118 RGRALGLLQAFGSVGGILG---PLLGGILA---SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 235 LPELFRNHWG--KVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKT 312
Cdd:cd06174 192 VLKLLKRVLKnpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 313 FIIGYVVIMIWEAVMWSILDQGPFLYIMTvAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAvLGGAFAPMIA 392
Cdd:cd06174 272 LLLIGLLLMALGLALLLLAPSLLLLLLLL-LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGF-LGGAIGPLLA 349
|
330 340
....*....|....*....|....*....
gi 512048596 393 QMIMDATGNPFYISVYLMAMAIPALIALF 421
Cdd:cd06174 350 GFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
75-424 |
2.74e-15 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 76.84 E-value: 2.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVW--------VLIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQagvplgLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVfqamqtesaersap 234
Cdd:cd17315 121 RGALGTLNQ------LMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 235 lpelfrnhwgkVIQGALIFAAQQATGYLVIAFFGAYAQKTLGyPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFI 314
Cdd:cd17315 181 -----------LLVGVGLQLLQQLTGINAVMYYAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 315 IGYVVIMIWEAVM-WSILDQGPFLYIMTVAVLTLPL-----ALTFGPQPAMY-SEMFPAEVRYSGASIAYA---IGAVLG 384
Cdd:cd17315 249 IGFAGMAASLLLLaIAFLLPALAKAAGWLALLGILLyiaafAMGAGPVPWLLlSEIFPLRIRGKGMAIATLvnwIFNFIV 328
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 512048596 385 GAFAPMIAQMImdatGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:cd17315 329 GLTFLIMVSTI----GLAGVFIFFAAVCLLALVFVFFFVP 364
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
75-424 |
3.20e-15 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 76.84 E-value: 3.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVftligMGAATFCIGLLPTYESIGIAapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLL-----ISAVLFFISALGSAFSPNFT---IFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTESAersap 234
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKPI----- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 235 lpelfrnhwgkVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFI 314
Cdd:cd17359 198 -----------LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 315 IG---YVVIMIWEAVMWSILDQGPFLYIMTVAVLTLPLA---LTFGPQP-AMYSEMFPAEVRYSGASIAYA---IGAVLG 384
Cdd:cd17359 267 IGsigMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAffaMSWGPVTwVLLSEIFPNRIRGLAMGIAVFflwIANFLV 346
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 512048596 385 GAFAPMIAQMImdATGNPFYISVYLMAMAIpaLIALFLLP 424
Cdd:cd17359 347 SLTFPILLAAF--GLAFTFLIFAVICVLAF--LFVWKFVP 382
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
66-423 |
2.39e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.14 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 66 LGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTyesigiaaPILLVLLRVFQGISAGGEWGGAALM 145
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS--------LTSLYVLRFLLGVAEAGFFPGAIKA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 146 SVEYAPKEKRGLYGAFPQAGVPLGLTLAtgtMLIVMAIVGeeaymDWGWRVPFLLSFIL-VLIGYMIRRSVdespvfqam 224
Cdd:cd17319 116 LAEWFPARERGRATGLFNSGAPLGAAIG---PPLSGWLLL-----LFGWRWAFIIEGLLgLLLAVLWWFYL--------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 225 qtesaersaplpelfrnhwGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWS 304
Cdd:cd17319 179 -------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 305 DRI---GRAKTFIIGYVVIMIweAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGA 381
Cdd:cd17319 240 DRLlrgARRLVIIIGLLLAAV--GLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGN 317
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 512048596 382 vLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPALIALFLL 423
Cdd:cd17319 318 -LGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
61-424 |
6.53e-14 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 73.45 E-value: 6.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 61 LAW-ATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLlptyeSIGIAAPILLVLLRVFQGISAGGEW 139
Cdd:cd17357 49 LLWsLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLST 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 140 GGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLAtgtMLIVMA-IVGEEAymdwGWRVPFLLSFILVLIGYMIRRSVDES 218
Cdd:cd17357 124 GFVPMYLQEISPSELRGALGSLTQIGVTLGILLG---QVFGLPsVLGTET----LWPYLLFFPGIPALLQLAALPFFPES 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 219 P-----------------------------VFQAMQTESAERSAP----LPELFRN---HWGKVIqGALIFAAQQATGYL 262
Cdd:cd17357 197 PkflliskgdeeeaekslkflrgieddvdqELEEIKKESEQMGDQkqvsLMQLLRDpslRLPLLL-VLVVSASQQFSGIN 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 263 VIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSIL----DQGPFLY 338
Cdd:cd17357 276 AIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLflseQNSWMSY 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 339 IMTVAVLTLPLALTFGPQPAMY---SEMFPAEVRYSGASIAYAIGAVlgGAFAPMIAQMIMDATGNPFYISVYLMAMAIP 415
Cdd:cd17357 356 GCIVAIFLFIFFFAIGLGPIPWfigAELFPQAPRSAAQSLGSSVNWT--SNFIVGMAFPPLQSIGGGFVFIIFAIPCALF 433
|
....*....
gi 512048596 416 ALIALFLLP 424
Cdd:cd17357 434 LLYLYRYLP 442
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-392 |
1.91e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 71.62 E-value: 1.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 1 MTTSIIANDPKQRRQ--VLTGTLVGTTIEFYDFLIYAQAAAIVLAPHFIEPAaqsnpQVAQVLAWATLGISFlfrplGAI 78
Cdd:TIGR00895 1 DVQNNIRKQPLSRYQwrAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPV-----QLGFLFSAGLIGMAF-----GAL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 79 VAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESigiaapilLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLY 158
Cdd:TIGR00895 71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 159 GAFPQAGVPLGLTLAtgtmlivmAIVGEEAYMDWGWRVPFLLSFIL-VLIGYMIRRSVDESPVFQAMQ------------ 225
Cdd:TIGR00895 143 VGLMFCGYPIGAAVG--------GFLAGWLIPVFGWRSLFYVGGIApLLLLLLLMRFLPESIDFLVSKrpetvrrivnai 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 226 --TESAERSAPLPELFRNHWGKVIQGALIFAAQQA---------TGYLVIAFFGA-----YAQKTLGYPATVAWTGTLVA 289
Cdd:TIGR00895 215 apQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTAritvllwllYFMLLVGVYFLtnwlpKLMVELGFSLSLAATGGALF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 290 GICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLtlplaLTFGPQPAMYSEM---FPA 366
Cdd:TIGR00895 295 NFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGF-----FVNGGQSGLYALMalfYPT 369
|
410 420
....*....|....*....|....*.
gi 512048596 367 EVRYSGASIAYAIGAvLGGAFAPMIA 392
Cdd:TIGR00895 370 AIRATGVGWAIGIGR-LGAIIGPILA 394
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-422 |
3.85e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 70.27 E-value: 3.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 53 SNPQVAQVLAWATLGISflfrpLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQG 132
Cdd:cd17324 32 SVAQAGLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 133 ISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLAtgtmLIVMAIVGEEaymdWGWRVPFLLSFILVLIG-YMI 211
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLG----RPLGGLLGQL----LGWRAAFLAIAVLALLAaLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 212 RRSVDESPVFQAMQTESAERsapLPELFRNhwGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGI 291
Cdd:cd17324 171 WRLLPSLPPKKPGSLGLLSS---LLLLLRN--PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 292 CWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSildqGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYS 371
Cdd:cd17324 246 AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL----GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 512048596 372 GASIAYAIGAVLGGAFAPMIAQMIMDATGnpfYISVyLMAMAIPALIALFL 422
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVLDHGG---WAGV-GWVGAALLLLALLL 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
33-446 |
6.87e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.93 E-value: 6.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 33 IYAQAAAIVLAPHFIEPAAQSNPQVAQVLAWATLgISFLFRPLGAIVAGHIGDRYG-RKMILVFTLIGMGAATFCIGLLP 111
Cdd:COG2211 24 LAFGLLSAYLLYFYTDVLGLSAALVGLILLVARL-WDAITDPLIGALSDRTRTRWGrRRPWILIGAIPLALSFVLLFTAP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 112 TYESIG--IAAPILLVLLRVFQGISAGGEWggaALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMAIVGEEAy 189
Cdd:COG2211 103 DLSPTGklIYALVTYLLLGLAYTLVNIPYS---ALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 190 mDWGWRVPFLLSFILVLIGYMI-RRSVDESPVFQAMQTESAERsapLPELFRNHWGKVIqgALIFAAQQATGYLVIAFFG 268
Cdd:COG2211 179 -ALGYRLTALIFAVLGLLAFLLtFFGTKERPVPEEEKVSLKES---LKALLKNRPFLLL--LLAYLLFFLALALVAALLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 269 AYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLP 348
Cdd:COG2211 253 YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIG 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 349 LALTFGPQPAMYSEMFPAEVRYSG---ASIAYAI---GAVLGGAFAPMIAQMIMDATG-------NPFYISVYLMAM--- 412
Cdd:COG2211 333 LGAILVLPWAMLADVVDYDEWKTGrrrEGLYFGIftfAIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFfll 412
|
410 420 430
....*....|....*....|....*....|....*
gi 512048596 413 -AIPALIALFLLPKGLEDRDLIEHPETNLDEVKSR 446
Cdd:COG2211 413 pAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
77-423 |
7.05e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.52 E-value: 7.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 77 AIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEKR- 155
Cdd:cd17474 51 MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERa 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 156 ---GLYGAFpqagvplgLTLATGTMLIVMAIVGeeaymDWGWRVPFLLSFILVLIGYMirrsvdespVFQAMQTESAERS 232
Cdd:cd17474 123 kamGLYEAA--------LGLGIAVGPLLGGLLA-----AISWRYPFFLLAALIPVAFL---------AILFLLPEPKEKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 233 APLPELFRNHWGKVIQGALIFAAQQATGYLVIAFFG--AYAQKTLG--YPATVAWTGTLVA--GICWTIFMFIAGAWSD- 305
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAflTYLPFLLEllYGISPIIIGLLFAgwSVLLALGSLFVGRLLKk 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 306 RIGRAKTFIIGYVVIMIWEAVMWSILDQGpfLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRySGASIAYAIGAVLGG 385
Cdd:cd17474 261 RFGARRILVIGLLLYALSLLLLGFVPSLA--LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER-GTASSLYNFVRFLGQ 337
|
330 340 350
....*....|....*....|....*....|....*...
gi 512048596 386 AFAPMIAQMIMDATGnpfyISVYLMAMAIPALIALFLL 423
Cdd:cd17474 338 AVGPLLFGLLLEIFG----LSAPFLVGAAIALAAAVLL 371
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
69-400 |
1.03e-12 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 69.73 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 69 SFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAapillvllRVFQGISAGGEWGGAALMSVE 148
Cdd:PRK03893 64 AFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIA--------RLVIGMGMAGEYGSSATYVIE 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 149 YAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMAIvgeeaymdWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTES 228
Cdd:PRK03893 136 SWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPV--------WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 229 AERSAPLPELFRNH--------------------WGKVIQGALI-------------FAAQQA-----TGYLVI------ 264
Cdd:PRK03893 208 APVRTMVDILYRGEhriinilltlaaaaalwfcfAGNLQNAAIVavlgllcaaifisFMVQSSgkrwpTGVMLMvvvlfa 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 265 --------AFFGAYAQKTLGY-PATVAwTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGyvvIMIWEAVMWSildqgp 335
Cdd:PRK03893 288 flyswpiqALLPTYLKTDLGYdPHTVA-NVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCS---LLISQLLIIP------ 357
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512048596 336 fLYIMTVAVLTLPLALTFGPQ----------PAMYSEMFPAEVRYSGASIAYAIGAvLGGAFAPMIAQMIMDATG 400
Cdd:PRK03893 358 -VFAIGGANVWVLGLLLFFQQmlgqgisgllPKLIGGYFDTEQRAAGLGFTYNVGA-LGGALAPILGALIAQRLD 430
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-424 |
1.56e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 68.38 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 37 AAAIVLAPHFIEPAAQSNPQVAQVLAWATLGISflfrpLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESi 116
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 117 giaapilLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATgtmliVMAIVGEEAymdWGWRV 196
Cdd:cd17365 90 -------LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGG-----FLAAALIPA---FGWRS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 197 PFLLSFILVLIgymirrsvdespvfqamqtesaersapLPELFRnhwgkviqGALIFAAQQATGYLVIAFFGAYAQKTL- 275
Cdd:cd17365 155 VFLLGGVPPLI---------------------------LLPLLR--------GTLLLWVTFFMGLLLVYLLNSWLPKLMv 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 276 --GYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVvimiWEAVMWSILDQGPFLYIMTVAVLTLPLALTF 353
Cdd:cd17365 200 eaGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFA----LGAVSLALLGVSPASLVLLYVLVFLAGACVN 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512048596 354 GPQPAMY---SEMFPAEVRYSGASIAYAIGAvLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:cd17365 276 GAQVGLYalaARFYPTEVRATGVGWALGVGR-LGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-422 |
3.05e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.62 E-value: 3.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 40 IVLAPHFIEPAAQSNPQVAQVLAWATLGiSFLFRPLgaivAGHIGDRYGRKMILVFTLIGMGAATFCIGLlptyesigIA 119
Cdd:cd17489 16 LPVLPLYAHDLGGSEAVAGLVVGLFTLA-ALLARPF----AGRLLDRFGRKRLLLIGLLIFALATLLYLL--------AT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 120 APILLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLAtgtmlivmAIVGEEAYMDWGWRVPFL 199
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALG--------PALGLFLYQHLGFAVLFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 200 LSFILVLIGYMIRRSVDESPvfqamQTESAERSAPLPELFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLgypA 279
Cdd:cd17489 155 VAAVLALLALLLVFLVKDPP-----PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERG---I 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 280 TVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIweaVMWSILDQGPFLYIMTVAVLtlpLALTFGP-QPA 358
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL---GLLLLSFAGSPWMLLLAAVL---YGLGFGLlFPA 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512048596 359 MYSEMF---PAEVRySGASIAYAIGAVLGGAFAPMIAQMIMDATGnpfYISVYLMAmAIPALIALFL 422
Cdd:cd17489 301 LQALAVdlvPPHRR-GAANGTFFIFFDLGIGLGGLLLGLVAELFG---YRAMFLLA-AVVVLLALVL 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
75-426 |
3.39e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.57 E-value: 3.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:COG0738 58 LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANPYVAALGPETA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFpQAGVPLGLTLAtgtMLIVMAIVGeeAYMDWGWRVPFL-LSFILVLIGYMIRRSvdESPVFQAMQTESAERSA 233
Cdd:COG0738 130 ASRLNLL-HAFFSLGALLG---PLLGGLLIL--LGLSLSWHLPYLiLAVLLLLLALLFLRS--KLPEIEEEEEEAAGSAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 234 PLPELFRNhwGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTF 313
Cdd:COG0738 202 SLKSLLKN--PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 314 IIGYVVIMIweAVMWSILDQGPFLYIMTVAVLTLPLALTFgpqPAMYSEMFPAEVRYSGASIAY-AIGAVLGGAFAPMIA 392
Cdd:COG0738 280 RLSALLAAV--GLLLALLAPGPWLALIGLALVGLGLSLMF---PTIFSLALDGLGKRTAAAVSAvLIMGIVGGAIGPPLI 354
|
330 340 350
....*....|....*....|....*....|....
gi 512048596 393 QMIMDATGnpfyISVYLMAMAIPALIALFLLPKG 426
Cdd:COG0738 355 GFLADAFG----LRAAFLVPLVCYLLILLLALAL 384
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
68-422 |
2.85e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 64.95 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 68 ISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLlptyesigIAAPILLVLLRVFQGISAGGEWGGAALMSV 147
Cdd:PRK12307 61 AAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL--------ASGVIMLTLSRFIVGMGMAGEYACASTYAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 148 EYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVmaivgEEAYmdwGWRVPFLLSFILVLIGYMIRRSVDESPVF-QAMQT 226
Cdd:PRK12307 133 ESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSF-----AEAY---GWRAAFFVGLLPVLLVIYIRARAPESKEWeEAKLS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 227 ESAERSAPLPELFRNHWGKVIQGA-------------LIFAAQQATGYLVIAFFGAYAQKT--LGYPATVAWTGTLVAGI 291
Cdd:PRK12307 205 GKGKHSQSAWSVFSLSMKGLFNRAqfpltlcvfivlfSIFGANWPIFGLLPTYLAGEGFDTgvVSNLMTAAAFGTVLGNI 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 292 CWtifmfiaGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYS 371
Cdd:PRK12307 285 VW-------GLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGL 357
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 512048596 372 GASIAYAIGAVlGGAFAPMIAQMIMDATGnpFYISVYLMAMAIPALIALFL 422
Cdd:PRK12307 358 GTGLIYNLAAT-SGTFNSMAATWLGITMG--LGAALTFIVAFWTATILLII 405
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-423 |
3.20e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.57 E-value: 3.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 35 AQAAAIVLAPhFIEPAAQ-SNPQVAQVLAWATLGISFlfrplGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTY 113
Cdd:cd17475 11 VAQGIPALAP-FLQEDLHlSLAQVGLLLSALNLGVAV-----SMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 114 esigiaaPILLVLLrVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLAtGTMLIVMAIVgeeaymdWG 193
Cdd:cd17475 85 -------PVLLVLL-FLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALA-AALLPPLALH-------YG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 194 WRVPFLLS-FILVLIGYMIRRSVDESPVFQAMQTESAERSAPLPELFRNH--WGKVIQGALIFAAQqatgYLVIAFFGAY 270
Cdd:cd17475 149 WRAAFVVAgLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRdvWLIAIAGALLVAPQ----FALLTFLLLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 271 AQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRI--GRAKTFIIGYVVIM-IWEAVMWSILDQGPFLYIMTVAVLTL 347
Cdd:cd17475 225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAaAALLVLSLLSPGTPLWLLVLLLILLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512048596 348 PLALTF-GPQPAMYSEMfpAEVRYSGASIAYAIGAVLGGAFA-PMIAQMIMDATGNpfYISVYLMAMAIPALIALFLL 423
Cdd:cd17475 305 LFAIGWnGLYLTLVAES--AGPEQAGTALGLANTINFIGIAIgPPLFGLLVDATHS--YAPAWLALALLLVLAALLLL 378
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
75-428 |
3.29e-10 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 61.50 E-value: 3.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFtligmGAATFCIGLLPTYESIGIAApiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQI-----GCVIYIIGAIIQVAAIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLAtgtmlivmaivgeeAYMDWG---------WRVPFLLSFILVLIGYMIRRSVDESPvfqamq 225
Cdd:cd17356 133 RGTLVSLYQLAITIGILVA--------------YCINYGthkldgsaqWRIPLGLQIVWGLLLLIGMFFLPESP------ 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 226 tesaersaplpelfrnHW-GKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWS 304
Cdd:cd17356 193 ----------------RWlYRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 305 DRIGRAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLP--------------LALTFGPQPAMY-SEMFPAEVR 369
Cdd:cd17356 257 DKFGRRTCLLIGAAGMSICLFIYAAVGVRYLIPNPQSGTSNKSAgngmivficlfifsFATTWGPIAWVYvAEVFPLRVR 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 512048596 370 YSGASIAYAIGAVLGGAFApMIAQMIMDATGNPFYIsVYLMAMAIPALIALFLLP--KGLE 428
Cdd:cd17356 337 SKGMALATAFNWLWNFLIS-FFTPFIIGSIGFKYYY-IFAGCNLLAFIVVFFFVPetKGLT 395
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
67-391 |
4.69e-10 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 61.21 E-value: 4.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 67 GISFLFRPLGAIVAGHIGDRYGRKmilvfTLIGMGAATFCIGLLptyesIGIAAPILLVLL--RVFQGISAGGEWGGAAL 144
Cdd:cd17362 46 SGSLLGALLGSLVAGALIDRLGRR-----KELILAALLYLVGSL-----VTGLAPSYPVLLvgRLIYGVGIGLAMHAAPV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 145 MSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMAIVgeeaymdWGWRVPFLLSFILVLIGYMIRRSVDESPVFQam 224
Cdd:cd17362 116 YIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLLGIGMWFLPPSPRWQ-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 225 qtesaersaplpelfRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPAtvAWTGTLVA---GICWTIFMFIAG 301
Cdd:cd17362 187 ---------------GNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSA--ASDATLVSvglGVFKLLMTIVAV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 302 AWSDRIGRAKTFIIGYVVIMIWEAVMWS----ILDQGPFLYIMTVAVLTLPLA---LTFGPQP-AMYSEMFPAEVRYSGA 373
Cdd:cd17362 250 LLVDKLGRRPLLLGGVSGMVVSLFLLAAynlfVQMGPAGLAWLSLVALLLYVGayqISFGPISwLMVSEIFPLRVRGRAI 329
|
330 340
....*....|....*....|..
gi 512048596 374 SIA----YAIGAVLGGAFAPMI 391
Cdd:cd17362 330 ALAvlvnFGSNALVSLAFLPLQ 351
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
29-425 |
6.81e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 60.37 E-value: 6.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 29 YDFLIYAQAAAIVLAPHFIEPAAQSNPQVAQVLAWATLGISFlfrplGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIG 108
Cdd:cd17364 13 YDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTII-----GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 109 LLPTYESIGIAApiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMAI----- 183
Cdd:cd17364 88 LSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIfehpl 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 184 -VGEEAYMDWGWRVPFLLSFILVLIGYMIRR-------------------SVDESPVFQAMQTESAErsAPLPELFRNhw 243
Cdd:cd17364 166 pAGTYHHADLVWRIVLGLGAIPALSVLYFRKhllgtagtwflldiafygqNLFQSTIISAIGFSKTM--NAYQELFNI-- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 244 gkviqgalifaaqqATGYLVIAFFGAyaqkTLGYpatvawtgtlvagicwtifmFIAGAWSDRIGRAKTFIIGYVVIMIW 323
Cdd:cd17364 242 --------------AVGQLIIALAGT----VPGY--------------------WFTVFLIDRIGRKKIQMMGFFGMTIF 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 324 EAVMWSILDQGPFLYIMTVAVLTLPLALT-FGPQPAMY---SEMFPAEVRYSGASIAYA---IGAVLGGAFAPMIAQMIm 396
Cdd:cd17364 284 LLILAGPYDHWKISTIGFFVLYGLTFFFSnFGPNTTTFivpAEVFPARVRSTCHGISAAsgkIGAIVGSFLFLSLTQNI- 362
|
410 420
....*....|....*....|....*....
gi 512048596 397 dATGNPFYIsvyLMAMAIPALIALFLLPK 425
Cdd:cd17364 363 -GVRNVLII---LAGVALLGIILTLLFPE 387
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
75-420 |
2.95e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.26 E-value: 2.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTyesigiaaPILLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RG----LYGAFpqagvpLGLTLATGTMLIvmAIVGEEAYMdwgwrvPFLLSFILVLIG----YMIRRSVDESPVFQAMQT 226
Cdd:cd17477 118 RGrvlgLYSTV------LGLGFALGPLLL--ALVGTAGAL------PFLIAAVLLLLAlvplLLTRRAAPEIEEAESISL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 227 ESAERSAPLPELfrnhwgkviqGALIFAAQQATGYLVIAFFGAyaqkTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDR 306
Cdd:cd17477 184 RRLLRIAPLALL----------GAFVAGFLEGAFYSLLPLYGL----RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 307 IGRAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTV----AVLTL-PLALTFGPQPAMYSEMFPAevrYSGASIAYAIGA 381
Cdd:cd17477 250 FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFlwggAAGPLyTLALALAGDRLPGDELVAA---NAALLLLYGLGS 326
|
330 340 350
....*....|....*....|....*....|....*....
gi 512048596 382 VLGgafaPMIAQMIMDATGNPFYIsVYLMAMAIPALIAL 420
Cdd:cd17477 327 VIG----PLLAGALMDAFGPHGLF-LFLAAVALLFLLFL 360
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
75-379 |
3.14e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 55.35 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTligmgAATFCIGLLptyesIGIAAPILLVLL--RVFQGISAGGEWGGAALMSVEYAPK 152
Cdd:cd17360 50 VGAAIGGWLNDRFGRRPCILLA-----DALFTIGAI-----VMAAAPNKEVLIvgRVLVGLGVGIASMTVPLYIAEAAPP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 153 EKRGlygafpqAGVPLGLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPvfqamqtesaers 232
Cdd:cd17360 120 RIRG-------RLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESP------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 233 aPLPELFRnhwgKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGY--PATVAWTGTLVAGiCWTIFMFIAGAWSDRIGRA 310
Cdd:cd17360 180 -RWPSTRR----ALIVGCGLQAFQQFSGINTVMYYSATILQMAGFkdNQNAIWLSLIVAG-TNFIFTIVGMYLIDKFGRR 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 311 KTFIIGyVVIMIWEAVMWSIldqgpFLYIMTVAVLTLPLALTFGPQP-AMYSEMFPAEVRYSGASIAYAI 379
Cdd:cd17360 254 KLLLIS-LFGVIVALVVLAV-----WLALVGLILYLAFFAPGMGPVPwTVNSEIYPLWARGTGGGCAAAV 317
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
75-424 |
5.64e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 55.02 E-value: 5.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIgiaapillVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVF--------LVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGltlatgtmLIVMAIVgeeAYMDWGWR-------VPFLLSFILVLIgymirrsVDESP--VFQAMQ 225
Cdd:TIGR00898 214 RAIVGTLIQVFFSLG--------LVLLPLV---AYFIPDWRwlqlavsLPTFLFFLLSWF-------VPESPrwLISQGR 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 226 TESAERSapLPELFRNHWGKVIQGALIFAAQQ-------ATGYLV-----------IAFFGAYAQKTLGYPATVAWTGTL 287
Cdd:TIGR00898 276 IEEALKI--LQRIAKINGKKLPAEVLSLSLEKdlssskkQYSFLDlfrtpnlrkttLCLMMLWFTTAFSYYGLVLDLGNL 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 288 VAGICWTIFMFIAGAWS---------DRIGRAKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPA 358
Cdd:TIGR00898 354 GGNIYLDLFISGLVELPaklitllliDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYL 433
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512048596 359 MYSEMFPAEVRYSGASIAYAIgAVLGGAFAPMIAQMimdATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:TIGR00898 434 YTAELYPTVVRNLGVGVCSTM-ARVGSIISPFLVYL---GEKWLFLPLVLFGGLALLAGILTLFLP 495
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
61-175 |
9.54e-08 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 53.51 E-value: 9.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 61 LAWATLGISFLFrplGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGEWG 140
Cdd:cd17379 37 LFQSSLNLGFLI---GSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWM 105
|
90 100 110
....*....|....*....|....*....|....*
gi 512048596 141 GAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLATG 175
Cdd:cd17379 106 TGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPG 140
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
65-422 |
1.55e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.38 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 65 TLGISFLFRPLGAIVAGHIGDRYG-RKMILVftligmGAATFCIGLLPTyeSIGIAAPILLVLLRVFQGISAGGEWGGAA 143
Cdd:cd17353 43 AFTLTIVFLAISAPFAGRLVDRGGpRKAILI------GGILFGLGFILS--AFAISLPLLFLGYGVLGGIGAGIGYITPV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 144 LMSVEYAPkEKRGLYGAFPQAGVPLGLTLATGTMLIVMAIVG-EEAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQ 222
Cdd:cd17353 115 STAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGvPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 223 AMQTESAERSAPLPELFRNHWGKVIQGALIFAAqqATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGA 302
Cdd:cd17353 194 ANNAENSPRDYTPREMLRTPTFWLLWLMFFLNA--TAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGW 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 303 WSDRIGRAKTFIIGYVVIMIWEAVMWSILDqGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAE---VRYSGASIAYAI 379
Cdd:cd17353 272 LSDKIGRKNTLSIAFLIQGVAMFLLPFIGS-VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKnagTNYGLLYTAKGV 350
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 512048596 380 GAVLGGAFAPMIAQMIMDATgnPFYISVYLMAMAipALIALFL 422
Cdd:cd17353 351 GGLIGPIIAAYVLYTGGYNA--AFIIAAALSLVA--LALALLL 389
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
75-379 |
1.79e-07 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 52.88 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLATGTMLIVmaivgeeAYMDWGWRVPFLLSFILVLIGYMIRRSVDESPVFQAMQTesaersap 234
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISNYAF-------ANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKD-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 235 lpelfrNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGY----PATVAWTGTLVAGICWTIfmfIAGAWSDRIGrA 310
Cdd:cd17435 188 ------NMRARLLIGLTLVFFVQITGQPNILFYASTVLKSVGFqsneAASLASTGVGVVKVVSTI---PAIFLVDKVG-S 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 512048596 311 KTFI-IGYVVIMIweavmwSILDQGPFLYIMTVAVLTLPLALTFGPQP-AMYSEMFPAEVRYSGASIAYAI 379
Cdd:cd17435 258 KTFLcIGSSVMAV------SLVTMGLWLSLASLLVYVAAFSIGLGPMPwLVLSEIFPGGIRGRAMALTSSM 322
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
75-425 |
2.74e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGewGGAALMSV--EYAPK 152
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAV--GNVLLPGLikRWFPD 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 153 eKRGLYGAFPQAGVPLGLTLATGTMLIVMAIvgeeaymdWGWRVPFLLSFILVLIGYMIRrsvdespVFQAMQTESAERS 232
Cdd:COG2807 138 -RVGLMTGLYTAAMGLGAALAAGLTVPLAAA--------LGWRGALAVWALLALLALLLW-------LPLLRRRPAAAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 233 APLPELFRNHW--GKVIQGALIFAAQQATGYLVIAFFGAYAQkTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRA 310
Cdd:COG2807 202 APAAASLRSLWrsPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 311 KTFIIGYVVIMIweAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGAS-IAYAIGAvLGGAFAP 389
Cdd:COG2807 281 RPLLLLLGLLGL--AGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSgMAQSVGY-LLAALGP 357
|
330 340 350
....*....|....*....|....*....|....*.
gi 512048596 390 MIAQMIMDATGNPFYISVYLMAMAIPALIALFLLPK 425
Cdd:COG2807 358 LLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
44-414 |
4.42e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.88 E-value: 4.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 44 PHFIEPAAQSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESigiaapil 123
Cdd:cd17391 20 PLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ-------- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 124 LVLLRVFQGISAGGEWGGAALMSVEyAPKEKrglygafpqAGVPLGlTLATGTM---LIVMAIVG--EEAYmdwGWRVPF 198
Cdd:cd17391 92 LLILRLLQGVFSGYVPNATALIASQ-TPKEK---------SGWALG-TLSTGVVagtLIGPLLGGflADLF---GIRNVF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 199 LL-SFILVLIGYMIRRSVDE--SPVFQAMQTESAER--SAPLPELFrnhWGKVIQGALIfaaqQATGYLVIAFFGAYAQK 273
Cdd:cd17391 158 FItGGLLFLAFLLTLFFVKEdfKPVEKKKMVSTKEVwnSVPNPSLL---ISLFVTTFII----QLANQSIEPILTLYIRQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 274 TLGYPATVAWTGTLVA---GICWTIFMFIAGAWSDRIGRAKTFIIG---YVVIMIWEAVMWSILDQGPFLYIMTVAVLTL 347
Cdd:cd17391 231 LMGDASNLAFISGLVFsatGVSSLLSAPRLGKLGDRIGHHRILLGAllaSALLYIPQAFVQTPWQLGILRFLLGLATGGL 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512048596 348 PLALTfgpqpAMYSEMFPAEVR-------YSGASIAYAIGAVLGGAFAPMIaqmimdATGNPFYISVYLMAMAI 414
Cdd:cd17391 311 LPAIN-----SLLAKITPKEVAgrifgynQSFQYLGNVAGPLLGSAIAAHF------GYRAVFVVTALLVLLNA 373
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
76-394 |
9.13e-07 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 50.71 E-value: 9.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 76 GAIVAGHIGDRYGRKMilvftLIGMGAATFCIGLLptyesIGIAAPILLVLL--RVFQGISAGGEWGGAALMSVEYAPKE 153
Cdd:cd17361 67 ASLLASYVTRKWGRKP-----SMLIGGVLFLVGAA-----LNAAAQNIAMLIvgRILLGFGVGFGNQAVPLYLSEMAPAK 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 154 KRGLYGAFPQAGVPLGLTLAT----GTMLIVmaivgeeaymDWGWRVPFLLSFILVLIGYMIRRSVDESPVFqamqtesa 229
Cdd:cd17361 137 LRGALNIGFQLAITIGILIANlinyGTSKIK----------PNGWRLSLGLAAVPALILLLGSLFLPETPNS-------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 230 ersaplPELfrnhwgkvIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGR 309
Cdd:cd17361 199 ------PQL--------VIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 310 AKTFIIGYVVIMIWEAVMWSIL-----DQGPFLYIMTVAVLTL------PLALTFGPQPAMY-SEMFPAEVRYSGASIA- 376
Cdd:cd17361 265 RFLLLEGGVQMLASQVAIGILLavkfgDGGELPKAYAIAVVVLiclyvaAFAWSWGPLGWLVpSEIFPLETRSAGQSLTv 344
|
330 340
....*....|....*....|.
gi 512048596 377 ---YAIGAVLGGAFAPMIAQM 394
Cdd:cd17361 345 avnFLFTFVIAQAFLSMLCAM 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
49-424 |
3.27e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.11 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 49 PAAQSNPQVAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLR 128
Cdd:cd17504 20 PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP--------VLIAGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 129 VFQGISAGGEWGGAALMSVEYAPKEkrglygafpqagVPLGLTLATGTMLIVMAI---VGEEAYMDWGWRVPFLLSFILV 205
Cdd:cd17504 92 ALQGIGGAVFPLAFALVREEFPPER------------VPVAQGILSATFGIGAGIglpLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 206 LIGYMIRRSVDESPVFQamqtesaersaplpelfRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTG 285
Cdd:cd17504 160 VLLAALVPLIDLRLLRR-----------------RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 286 TLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIwEAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFP 365
Cdd:cd17504 223 LLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV-GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 366 AE-----------VRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:cd17504 302 PDrtgiatgmntvLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
74-424 |
4.53e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 48.73 E-value: 4.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 74 PLGAIVAGHIGDRYGRKMILVFTLIgmgaatFCI-GLLPTYESIGIaapILLVLLRVFQGISAGGEWGGAALMSVEYAPK 152
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAI------PCIlGWLLIAFAKDV---WMLYLGRFLAGFGGGAASVVVPVYIAEIAPK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 153 EKRGLYGAFPQAGVPLGLTLA--TGTMLivmaivgeeaymdwGWRVPFLLSFILVLIGYMIRRSVDESPVFQAM--QTES 228
Cdd:cd17358 126 NVRGALGSLNQLLVNIGILLGyvLGSFL--------------PWRTLALIGAIPPVVFLILLFFIPESPRWLAKkgREEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 229 AERS-------------------------------APLPELFRNHWGK-VIQGALIFAAQQATGYLVIAFFGA--YAQKT 274
Cdd:cd17358 192 AEKSlqflrgkdadiskeaaeiqeelaelekeakeSSFSDLFQRKYLKpLVIGLGLMLFQQLSGINAVIFYASsiFDEAG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 275 LGYPATvawTGTLVAGICWTIFMFIAGAWSDRIGRAKTFII---GYVVIMIWEAV---MWSILDQGPFLYIMTVAVLTLP 348
Cdd:cd17358 272 SGLDPN---TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVsaiGMGIGLLALGLyfyLQEHGALLSSVSWLPLVGLVIY 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 349 L---ALTFGPQPA-MYSEMFPAEVRYSGASIAYAIGAVLGGAFApMIAQMIMDATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:cd17358 349 IisfSIGLGPLPWvIMSEIFPAKIKGLAGSLVTLVNWLFAFIVT-KTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVP 427
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
38-425 |
8.00e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 48.03 E-value: 8.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 38 AAIVLAPHFIEPAAQSNPQVAQVLAWATLGISflfrpLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESig 117
Cdd:PRK11551 33 SAGVAAPRMAQEFGLDVAQMGWAFSAGILGLL-----PGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS-- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 118 iaapilLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLYGAFPQAGVPLGLTLAtgtmlivmAIVGEEAYMDWGWRVP 197
Cdd:PRK11551 106 ------LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALA--------SVIGVLAAGDAAWRHI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 198 FLLSFI--LVLIGYMIrRSVDESPVFQAMQTESAERSAPLPELFRNhwgkviqgalifAAQQATGYLVIAFFGA------ 269
Cdd:PRK11551 172 FYVGGVgpLLLVPLLM-RWLPESRAFAQAAGAGKQRAPVLRALFGE------------GRATATLLLWISYFFTlivlyf 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 270 --------YAQKTLGYP-ATVAWTGTLVAGICWTIFMfiaGAWSDRIGRAKTFIIGYVVImiweAVMWSILDQGPFLYIM 340
Cdd:PRK11551 239 llnwlpslLVGQGLSRSqAGLVQIAFNIGGALGSLLI---GALMDRLRPRRVVLLIYAGI----LASLAALAAAPSFAGM 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 341 TVAVLTLPLALTfGPQPAMY---SEMFPAEVRYSGASIAYAIGAvLGGAFAPMIA-QMIMDATGNPFYISVYLMAMAIPA 416
Cdd:PRK11551 312 LLAGFAAGLFVV-GGQSVLYalaPLFYPTQVRGTGVGAAVAVGR-LGSMAGPLLAgQLLALGRSTVGVIGASIPVILVAA 389
|
....*....
gi 512048596 417 LIALFLLPK 425
Cdd:PRK11551 390 LAALLLVSR 398
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
77-423 |
1.13e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.23 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 77 AIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGIsagGEWGGA----ALMSvEYAPK 152
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--------WQLLLFRALVGI---GEASYSpiapTIIA-DLFPK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 153 EKRGLYGAFPQAGVPLGLTLAtgtmLIVMAIVGEEAYmDWGW--RVPFLLSFILVLIGYMI----RRSVDESPVFQAMQT 226
Cdd:cd17328 119 EKRTRALGVFYFAIPLGSGLG----YVVGGLVAQATG-GWRWafRVTGVLGVLLAILLLLFvrepPRGAAEGGVMAKSTA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 227 ESAERSapLPELFRNH--WGKVIQGALIFAAQQATGYLVIAFFgAYAQKTLGYPAT-VAWTGTLVAGICWTIFMFIAGAW 303
Cdd:cd17328 194 TSFLAD--LKALAKNPsfILSTLGFTAVSFVTGALAFWAPTFF-LRAFGVGDLSSAdVGLIFGAITCIAGVLGVLLGGIL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 304 SDRIG----RAKTFIIGYVVIM---IWEAVMWSILDQGPFLYIMtVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIA 376
Cdd:cd17328 271 ADRLRrktpRADPLVCAVGLLAaapFLFLALVLALSNLLLAWVL-LFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQ 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 512048596 377 YAIGAVLGGAFAPMIAQMIMDATGNPFYISVY---------LMAMAIPALIALFLL 423
Cdd:cd17328 350 ILLSHLLGDAGSPYLIGLISDLLRQNKDSPLAeaaslqyalLLCSFVLVLGGFFFL 405
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
79-420 |
1.20e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 79 VAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESigiaapilLVLLRVFQGISAGGEWGGAALMSVEYAPKEKRGLY 158
Cdd:cd17503 50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 159 GAFpqAGVPLGLTLATGTML---IVMAivgeeaymdWGWRVPFLLSFILVLIGYMIrrsvdeSPVFQamqtesaersapl 235
Cdd:cd17503 122 MGL--VGLVILLAPAIGPTLggwLTDN---------LSWRWIFYINLPIGILALLL------APLLD------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 236 PELFRNHwgKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFII 315
Cdd:cd17503 172 LRLFKDR--NFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 316 GYVVIMIWEAVMWSILDQGPFLYIMTV-AVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIaYAIGAVLGGAFAPMIAQM 394
Cdd:cd17503 250 GLLLLALGTLLLAFLTPDTSLWLIILPlFIRGLGMGLVFMPLNTLALNSLPPEQIGDATAL-FNTIRQLGGSIGTALLAT 328
|
330 340
....*....|....*....|....*.
gi 512048596 395 IMDATGNPFYISVYLMAMAIPALIAL 420
Cdd:cd17503 329 LLTNRTQFHHSRLSELLAQQVQKQAL 354
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
64-429 |
1.24e-05 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 47.42 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 64 ATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAApiLLVLLRVFQGISAGGEWGGAA 143
Cdd:TIGR00887 60 AVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 144 LMSVEYAPKEKRGLYGAFPQAGVPLGLTLATGTMLIVMAI----VGEEAY-----------MDWGWRVPFLLSFILVLIG 208
Cdd:TIGR00887 138 IITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALIVLAGfkhsLEAAADeasctgscvpaVDYMWRILIGFGAVPALLA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 209 YMIRRSVDESPVFQAM----------------------QTESAERSAPLPELFRNHWGKVIQ-------GALIFAAQQAT 259
Cdd:TIGR00887 218 LYFRLTIPETPRYTADvakdveqaasdmsavlqvkieaEPDEVEKASTAVEVPKASWSDFFThffkwrhGKHLLGTAGSW 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 260 GYLVIAFFG-----AYAQKTLGYPATVAWT-------GTLVAGICWTIFMFIAGAW-----SDRIGRAKTFIIGYVVIMI 322
Cdd:TIGR00887 298 FLLDIAFYGvnlnqKVILSAIGYSPPAATNnayeelyKTAVGNLIIALAGTVPGYWvtvflVDIIGRKPIQLMGFFILTV 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 323 WEAVM---WSILDQGPFLYIMTVAVLTlplaLTFGPQPAMY---SEMFPAEVRYSGASIAYA---IGAVLgGAFAPMIAQ 393
Cdd:TIGR00887 378 LFFVLgfaYNHLSTHGFLAIYVLAQFF----ANFGPNATTFivpGEVFPTRYRSTAHGISAAsgkAGAII-GQFGFLYLA 452
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 512048596 394 MIMDATGNPFYISVYLMAMAIPALIAL------FLLP----KGLED 429
Cdd:TIGR00887 453 QHGDPTKGYPTGIWMGHVLEIFALFMFlgilftLLIPetkgKSLEE 498
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
75-364 |
1.61e-05 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 46.84 E-value: 1.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESigiaaPILLVLLRVFQGISAGgewggaALMSV------E 148
Cdd:cd17432 65 FGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKS-----FEMIIVGRFLVGINAG------ISLNVvpmylgE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 149 YAPKEKRGLYGAFPQAGVPLGLTLatGTMLIVMAIVGEEAymdwGWrvPFLLSFILV--LIGYMIRRSVDESPVF----- 221
Cdd:cd17432 134 SAPKNLRGAVGLVPAIFITLGILL--GQVLGLRELLGNEE----GW--PLLLALTGVpaLLQLLTLPFFPESPRYlliek 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 222 -------QAMQT--------------------ESAERSAPLPELFRNH---WgKVIQGALIFAAQQATGYLVIAFFGAYA 271
Cdd:cd17432 206 gdeeaarKALQRlrgkedvddemeemleeqraEKGVGTVSVLELFRDRsvrW-QLISIIVLMAGQQLCGINAIYFYADSI 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 272 QKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSIL---DQGPFL-YIMTVAVLTL 347
Cdd:cd17432 285 FLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALslqNTVSWMpYLSIVCIFAY 364
|
330 340
....*....|....*....|
gi 512048596 348 PLALTFGPQP---AMYSEMF 364
Cdd:cd17432 365 IASFGIGPAGvpfILTTEIF 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
75-424 |
1.74e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--------ALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 R----GLYGAFpqagVPLGLTLATgtmlivmAIVGeeAYMDWGWRVPFLLSFILVLIGYMIRRSVDESpvfqaMQTESAE 230
Cdd:cd17473 122 RakmlGLQSAA----MSLGGVVFL-------LLGG--ALAEIGWRAPFLVYLLALPVLILVLLFLPEP-----ARKSKSA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 231 RSAPLPELFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPAtvAWTGTLVAGIcwTIFMFIAGAWSDRIGRA 310
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSA--ALIGLALAIA--SLAGAIGALLFGRLKRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 311 KTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLPLALTFGpQPAMYS---EMFPAEVRysGASIAYAIGAVLGGAF 387
Cdd:cd17473 260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL-LPTLNSwamSLVPPELR--GRAMGIVTSAFFLGQF 336
|
330 340 350
....*....|....*....|....*....|....*...
gi 512048596 388 A-PMIAQMIMDATGNPFYISVYLMAMAIPALIALFLLP 424
Cdd:cd17473 337 LsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
67-418 |
3.47e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.61 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 67 GISFLFRplgaIVAGHIGDRYGRKMILVFtlIGMGAATFCIGLLPTYESIGIAApILLVLLRVFQGI-SAGGEwggaALM 145
Cdd:cd17370 45 ALGSLLR----LFSGYLSDRTGKRKPLVI--LGYGLSALAKPLLALAGSWQLVL-LLRILERLGKGIrTPPRD----ALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 146 SvEYAPKEKR----GLYGAFPQAGVPLGLTLATGTMlivmaivgeeAYMDWGWRVPFLLSFI------LVLIGYMIRRSV 215
Cdd:cd17370 114 A-DATPPSGRgkafGLHRALDTLGAVLGPLLAALLL----------YLLGGNYRTIFLLAAIpallalLILLFVVKEYPR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 216 DESPVFQAMQTESAERSAPLPelfrnhwgkviqGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICwTI 295
Cdd:cd17370 183 PPKLRKKSKKTSLKKLPKAFW------------LYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVY-AL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 296 FMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMwsILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSG--- 372
Cdd:cd17370 250 AAYPAGRLSDRIGRKKLLILGYLSLALAYLGF--ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAygl 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 512048596 373 ASIAYAIGAVLGGAFAPMIAQMIMDATgnPFYISVYLMAMAIPALI 418
Cdd:cd17370 328 FNTVVGIGWLLASLIAGYLWDLISPSA--AFLFSAVLALIALLLLL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
78-423 |
4.24e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 45.63 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 78 IVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTyesigiaaPILLVLLRVFQGIsaggewGGAALMS------VEYAP 151
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGI------GAAAIMPaslaliAATFP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 152 KEKR----GLYGAFPQAGVPLGLTLatGTMLIVMaivgeeaymdWGWRVPFLLSFILVLIGYMirrsvdespvfqamqte 227
Cdd:cd17321 115 GERRgralGLWGAVVGIGAALGPLL--GGLLLEL----------FGWRWIFLINVPIGLVALL----------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 228 saersaplpeLFRNHWGKVIQGALIFAAQqatgYLVIAFFGAYAQKTLGYPATvaWTGtlVAGICWTIFMF----IAGAW 303
Cdd:cd17321 166 ----------LARTFSGAVLAAFLLGAAL----GGLLFLLPLYLQGVLGYSPL--QAG--LALLPLALAMLvaapLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 304 SDRIGRAKTFIIGYVVIMIWEAVM-WSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAE-----------VRYS 371
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEkagaasgilntARQL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 512048596 372 GASIAYAI-GAVLGGAFAPMIAQMIMDATG---NPFYISVYLMAMAIPALIALFLL 423
Cdd:cd17321 308 GGALGVALlGALLTAGLSANLGDSGVAALLsaaAAAFAAGFHLAFLVAAALALLAA 363
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
67-385 |
6.18e-05 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 45.08 E-value: 6.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 67 GISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMS 146
Cdd:cd17437 39 GSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 147 VEYAPKEKRGLYGAFPQAGVPLGLTLatgtmlivmaivgeeaymdwGWRVPFLLSFILVLIGYMIRRSVDESP-VFQAMQ 225
Cdd:cd17437 111 AEVAPASSRGFLTSFPEIFINIGILL--------------------GYVSNYAFSGLPLHVGWRLMLGVGAVPsLFLAIG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 226 TesaersAPLPELFRnhWGKVIQGALIFA-----AQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVA-GICWTIFMFI 299
Cdd:cd17437 171 V------LAMPESPR--WTPAVRRMLIAAlgihfFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAvGVTKTLFILV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 300 AGAWSDRIGRAK---TFIIGYVVIMIWEAVMWSILDQ-------GPFLYIMTVAVLTLPLALTFGPQPAMY-SEMFPAEV 368
Cdd:cd17437 243 ATFLLDKVGRRPlllTSTGGMTLSLTALATSLTFIDRngggltwALVLAITAVCSFVAFFSIGAGPITWVYsSEIFPLRL 322
|
330
....*....|....*..
gi 512048596 369 RYSGASIAYAIGAVLGG 385
Cdd:cd17437 323 RAQGASLGVVVNRLMSG 339
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
75-424 |
6.96e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 6.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLATGTmlivmaivgeeAYM--DWGW--RVPFLLSFILVLIGYMI-RRSVDESPVFQAMQtesa 229
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALL-----------AYLirDWRWlqLAISLPGLLFLLLLWWLpRRTIIVGLIWFVTS---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 230 ersaplpelfrnhwgkVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPatvawtgtlvagICWtIFMfiagawsDRIGR 309
Cdd:cd17317 177 ----------------LVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYF------------LAL-LLL-------DRLGR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 310 AKTFIIGYVVIMIWEAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVlGGAFAP 389
Cdd:cd17317 221 RWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARV-GAILAP 299
|
330 340 350
....*....|....*....|....*....|....*
gi 512048596 390 MIAQMIMDATGNPFYIsvyLMAMAIPALIALFLLP 424
Cdd:cd17317 300 FIVLLGKIGPLLPLII---FGVLALLGGLLTLLLP 331
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
81-424 |
8.06e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 8.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 81 GHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISAGGewggaalmsVEYAPKEKRGLYGA 160
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARL---------ASQAAGGRRGLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 161 FPQAGVPLGLTLATgtmLIVMAIVGEEAYMDWGWrvpfLLSFILVLIGYMIRRSVDESPVfqamQTESAERSAPLPELFR 240
Cdd:cd17478 123 IFSVGGNLGFALGP---LIAAALVALFGGLGLLI----LLIIPGLAVALLLLRLRPLKKP----EAKKAAAKSSARSTLK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 241 NHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICwTIFMFIAGAWSDRIGRAKTFIIGYVVI 320
Cdd:cd17478 192 GVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAG-AIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 321 MIweAVMWSILDQGPFLYIMTVAVLTLpLALTFGPQPAMYSEMFPAEVRYsGASIAYAIGAVLGGAFAPMIAqMIMDATG 400
Cdd:cd17478 271 AP--FLLLFLLTPGIWSYILLVLAGFL-LFASFPVTVVLAQELLPGNVGL-ASGLMMGLSFGLGGIGAPVLG-ALADAFG 345
|
330 340
....*....|....*....|....
gi 512048596 401 npfyISVYLMAMAIPALIALFLLP 424
Cdd:cd17478 346 ----LESVLLILALLPLLGALLAF 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
64-425 |
9.23e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 9.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 64 ATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLrvfqgISAGGEWGGAA 143
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFL-----LGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 144 LMSV--EYAPKEKRGLYGAFpqagvplgLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGY----MIRRSVDE 217
Cdd:cd06173 113 RQALlpELVPKEQLVRANAL--------NSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAllllFIRRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 218 SPVFQAMQTESAERSAPlpeLFRNHWGKVIQGALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFM 297
Cdd:cd06173 185 APGESSSLLLRDLREGL---RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 298 FIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWSILDqgPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVR-------Y 370
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgrvfsvyN 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 512048596 371 SGASIAYAIGAVLGGAFAPMIAQMImdatgnpfyisVYLMAMAIPALIALFLLPK 425
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSA-----------VFLLAGALLLLAALLLLLL 383
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
75-207 |
1.91e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 41.48 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNIT--------VLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 512048596 155 RGLYGAFPQAGVPLGLTLAtgtmlivmAIVGEEAYMDWGWRVPFLLSFILVLI 207
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLG--------PPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
56-423 |
2.08e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.33 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 56 QVAQVLAWATLGISflfrpLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGIsa 135
Cdd:cd17320 35 AVQLTLSAYLLGFA-----LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFLQGL-- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 136 ggewGGAALMSVEYApkEKRGLYGAFPQAGVplgLTLATGTMLIVMAI---VGEEAYMDWGWRVPF--LLSFILVLIGYM 210
Cdd:cd17320 100 ----GAAAGSVVARA--IVRDLYSGAELAKI---FSLLMMILAIAPALaplLGGLLLLFFGWRAIFvfLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 211 IRRSVDESPVFQAMQTESAERSApLPELFRNH--WGKVIQGALIFAAQQAtgYLVIAFFgaYAQKTLGY-PATVAWTGTL 287
Cdd:cd17320 171 LLFLPETLPEEKRKPLLSSLLRA-YKRVLKNRrfLGYALALGLSFAGLFA--YLAAAPF--IYIEQLGLsPAQFGLLFAL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 288 VAGIcwTIFM-FIAGAWSDRIGRAKTFIIGYVVIMI---WEAVMWSILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEM 363
Cdd:cd17320 246 NAIA--LILGsLLNGRLVRRFGPRRLLRLGLLLLLAaalVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEP 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 364 FPaEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATGNpfyISVYLMAMAIPALIALFLL 423
Cdd:cd17320 324 FP-HVAGTASALLGFLQFLIGALAGALVGLLPNGTALP---MGLLILVLGLLALLLLILL 379
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
74-204 |
2.11e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 43.05 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 74 PLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYEsigiaapiLLVLLRVFQGISAGGEWGGAALMSVEYAPKE 153
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFP--------VYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 512048596 154 KRglygafPQAGVPLGLTLATGTMLIvmaivGEEAYM--DWGW-----RVPFLLSFIL 204
Cdd:cd17374 121 HR------ALAITLTSCFFSIGQMLL-----AGLAYAirDWRLlqlvvSVPFFLFFLY 167
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-431 |
2.32e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 250 ALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTlVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIweAVMWS 329
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVT-AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL--GSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 330 ILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRySGASIAYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYL 409
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR-GRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180
....*....|....*....|..
gi 512048596 410 MAMAIPALIALFLLPKGLEDRD 431
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAAR 193
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
68-424 |
2.64e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 2.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 68 ISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTyesigiaAPILLVLLRVFQGISAGGEWGGAALMSV 147
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS-------LWQLYLLWGLLGGGGAGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 148 EYAPKEKRGLygafpqagvPLG-LTLATGTMLIVMAIVGEEAYMDWGWR-----VPFLLSFILVLIGYMIRRSVDESPVF 221
Cdd:cd17355 119 AWWFERRRGL---------ALGiLTAGGGLGSLVFLPLGAALIEAFGWRtallvLALLALLVLVPVLLLLRRRPADLALR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 222 QAMQTESAERSAPLPELFRNHWGKVIQGALIFAAqqATGYLVIAFFGAYAQKTLGYPATVAWTGTLVaGICWTIFMFIAG 301
Cdd:cd17355 190 AYDDASPASPGSTLKEALRSASFWLLALAFFLCG--FAVVGLIVHLVPYLADRGISPAAAAVALALI-GLFNIVGRLLSG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 302 AWSDRIGRAKTFIIGYVVIMIWEAVMWSiLDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGA 381
Cdd:cd17355 267 WLGDRYSPRRLLAASYALRALGLALLLL-LPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 512048596 382 VlGGAFAPMIAQMIMDATGNpfYISVYLMAMAIPALIALFLLP 424
Cdd:cd17355 346 L-GSALGPWLGGLLYDRTGS--YTAAWALAVALGLIAALLVLP 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
250-425 |
8.71e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 8.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 250 ALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVMWS 329
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 330 IldQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIaYAIGAVLGGAFAPMIAQMIMDATGNPFYISVYL 409
Cdd:cd06174 81 A--PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFLI 157
|
170
....*....|....*..
gi 512048596 410 MA-MAIPALIALFLLPK 425
Cdd:cd06174 158 AAaLALLAAILLLLVVP 174
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
75-423 |
1.05e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.06 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLptyesigiAAPILLVLLRVFQGISAG-GEWGGAALMSVEYAPKE 153
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA--------HSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 154 KRGLYGAFpqaGVPLGLTLATGTMLIVMAIVGEEAYMDWGWRVPFLLSFILVLIGymirrsVDESPVFQAMQTESAERSA 233
Cdd:cd17329 122 RTRAFSLL---YWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFL------LPETRPKRRAAEKTEILRG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 234 PLPEL-FRNHWGKVIQGALIFAA-QQATGYLVIaffgaYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAK 311
Cdd:cd17329 193 YKIVLrDRAFLLFLLASFLISLIyFQLESTLPV-----YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 312 TFIIGYVVIMIWEAVMWSIldQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVR--YSGasiAYAIGAVLGGAFAP 389
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFA--NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRgsYMG---FYALAWGLGRAIGP 342
|
330 340 350
....*....|....*....|....*....|....
gi 512048596 390 MIAQMIMDAtGNPFYISVYLMAMAIPALIALFLL 423
Cdd:cd17329 343 LVGGLLLDL-LGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-208 |
1.35e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 57 VAQVLAWATLGISFLFRPLGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAApillVLLRVFQGISAG 136
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF----ILWGLYMGAQES 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512048596 137 GEwggAALMSvEYAPKEKRGL-YGAFpQAGVPLGLTLATgtmLIVMAIvgeeaYMDWGWRVPFLLSFILVLIG 208
Cdd:cd17370 307 IE---RAAVA-DLVPAELRGTaYGLF-NTVVGIGWLLAS---LIAGYL-----WDLISPSAAFLFSAVLALIA 366
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
75-376 |
1.61e-03 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 40.78 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRK--MILVFTLIGMGAAtfCIGLLPTYESIgiaapILLVLLRVFQGISAGGEWGGAALMSVEYAPK 152
Cdd:cd17431 65 IGSFSVGLFVNRFGRRnsMLYNNLLAFAGAA--LMGLSKLAKSY-----EMLILGRFIIGLYCGLTTGLVPMYIGEISPT 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 153 EKRGLYGAFPQAGVPLGLTLATgtmlivmaIVGEEAYMDWGWRVPFLLSFILV-------------------LIGYM--- 210
Cdd:cd17431 138 ALRGALGTLHQLGIVVGILISQ--------IFGLEFILGTEELWPLLLGFTIVpailqlallpfcpesprylLINRNeee 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 211 --------IRRSVDESPVFQAMQTESA----ERSAPLPELFRN--HWGKVIQGALIFAAQQATGYLVIAFF--GAYAQKT 274
Cdd:cd17431 210 eaksvlkkLRGTTDVSEDIQEMKEESRqmmrEKKVTILELFRSssYRQPIIIAIVLQLSQQLSGINAVFYYstSIFEKAG 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 275 LGYPAtvawTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIWEAVM---WSILDQGPFL-YIMTVAVLTLPLA 350
Cdd:cd17431 290 VQQPV----YATIGAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAICAILMtiaLLLLEGYPWMsYVSIVAIFGFVAF 365
|
330 340
....*....|....*....|....*....
gi 512048596 351 LTFGPQPA---MYSEMFPAEVRYSGASIA 376
Cdd:cd17431 366 FEIGPGPIpwfIVAELFSQGPRPAAMAVA 394
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
250-440 |
1.94e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 250 ALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSD----RIGRAKTFI-IGYVVIMIWE 324
Cdd:COG2211 16 GLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWIlIGAIPLALSF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 325 AVMWSILDQGP----FLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVRYSGASIAYAIGAVLGGAFAPMIAQMIMDATG 400
Cdd:COG2211 96 VLLFTAPDLSPtgklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFG 175
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 512048596 401 NPFYISVYLMA--MAIPALIALFLLPKGLEDRDLIEHPETNL 440
Cdd:COG2211 176 GDAALGYRLTAliFAVLGLLAFLLTFFGTKERPVPEEEKVSL 217
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
75-394 |
2.04e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 40.30 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYESIGIAAPILLVLLRVFQGISaggeWGGAALMSVEYAPKEK 154
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQGMG----WPPSGRTMVHWFSKKE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLATGTMLIVMAIVGEEaymDWGWR--VPFLLSFILVLIGYMIRRSVDES-------------P 219
Cdd:cd17345 129 RGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDG---WWRGAfiFPAIIAIIVAVIVLFLGKDTPESeglppieeykgdyP 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 220 VFQAMQTESAERSAplPELFRNHwgkVIQGALIFAAQQATGYLVIAFFG------AYAQKTLGY-PATVAWTGTL--VAG 290
Cdd:cd17345 206 EEADGEEEEQELSA--WEIFVKY---VLKNKLLWYIAIANVFVYLVRYGildwapTYLSEVKGFsKAQAMWAFSLfeWAA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 291 ICWTIfmfIAGAWSDRIG---RAKTFIIGYVVIMIWEAVMWsildQGPFLYIMTVAVLTLPlALTFGPQ-----PAMysE 362
Cdd:cd17345 281 IPGTL---LAGWLSDKLFkgrRAPTGIIFMILVIVALIVYW----LAPNVLVDLIALIALG-FLIYGPVmliglQAL--E 350
|
330 340 350
....*....|....*....|....*....|....*.
gi 512048596 363 MFPAEVRYSGASI----AYAIGAVLGGAFAPMIAQM 394
Cdd:cd17345 351 LVPKKAAGTAAGLtglfGYLGGSVLATALIGIIVDH 386
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
250-423 |
2.65e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.92 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 250 ALIFAAQQATG-YLVIAFFGAYAQKTLGYPATVAWTgTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVimiweAVMW 328
Cdd:cd06179 2 ALCLAYFAQLFgVTLPAAVLPFIVADLGPSSNSTWI-STAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLL-----GVVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 329 SILdQGPFLYIMTVAVLTLPLALTFGPQPAMY---SEMFPAEVRYSGASIAYaIGAVLGGAFAPMIAQMIMDATGN---- 401
Cdd:cd06179 76 SIV-AGTAKSVNMLIGGQALIGIGAGTQGLGAavaSELVPNKYRGLVQGVVN-LVASPGSALGPLIAGALVEANAAgwrw 153
|
170 180
....*....|....*....|..
gi 512048596 402 PFYIsvyLMAMAIPALIALFLL 423
Cdd:cd06179 154 IFYI---NAIFNALALILLFFF 172
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
250-423 |
4.30e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 250 ALIFAAQQATGYLVIAFFGAYAQKTLGYPATVAWTGTLVAGICWTIFMFIAGAWSDRIGRAKTFIIGYVVIMIweAVMWS 329
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL--GLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 330 ILDQGPFLYIMTVAVLTLPLALTFGPQPAMYSEMFPAEVR---YSGASIAYAIGAVLGGAFAPMIAQMimdatgnpFYIS 406
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERgraLGLVSAGFGLGAALGPLLGGLLASL--------FGWR 151
|
170
....*....|....*..
gi 512048596 407 VYLMAMAIPALIALFLL 423
Cdd:pfam07690 152 AAFLILAILSLLAAVLL 168
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
75-400 |
8.37e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.13 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 75 LGAIVAGHIGDRYGRKMILVFTLIGMGAATFCIGLLPTYesigiaapILLVLLRVFQGISAGGEWGGAALMSVEYAPKEK 154
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL--------WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 155 RGLYGAFPQAGVPLGLTLATGTMLIVMAIVgeeaymdWGWRVPFLL--------SFILVLIGYMIRRSVDESPVFQaMQT 226
Cdd:TIGR00881 117 RGTWVSFWNCSHNVGGGLLPPLVLFGIAEL-------YSWHWVFIVpgiiaiivSLICFLLLRDSPQSCGLPPAEE-MPN 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 227 ESAERSAPLPELFRNHWGKVIQGAL--IFAAQQATGYLVIAF--------FGAYAQKTLGYPATVAWTGTL---VAGICW 293
Cdd:TIGR00881 189 EEPDGDAEKKEEELTKKQIFLQYVLlnKVLWYISLGYVFVYVvrtgildwSPLYLTQEKGFSKEKASWAFTlyeLGGLVG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512048596 294 TIfmfIAGAWSDRIGRAKTFIIGYV---VIMIWEAVMWSILDQGPFLYIMTVAVLTLplaLTFGPQpamysemFPAEVRY 370
Cdd:TIGR00881 269 TL---LAGWLSDKLFNGRRGPLAVFfmaLIIVSLLVYWLNPAANPLMDLICLFALGF---LVYGPQ-------MLIGVIA 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 512048596 371 SGASIAYAIGAV---------LGGAFAPMIAQMIMDATG 400
Cdd:TIGR00881 336 SELAPKKAAGTAagfvgffayLGGILAGLPLGYLADGFG 374
|
|
| |
