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Conserved domains on  [gi|512181387|gb|EPE02075|]
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PAS domain S-box protein [Sutterella wadsworthensis HGA0223]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 534-808 1.06e-55

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 195.79  E-value: 1.06e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 534 RWFDVRSQRIVWTRGETAVMVIATDITKRRELDLAR---EAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANAA 610
Cdd:COG4191   91 EALLLLLLAALDAEENAELEELERDITELERAEEELrelQEQLVQSE---KLAALGELAAGIAHEINNPLAAILGNAELL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 611 ATMLANgTLSKEREAQSYARIENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:COG4191  168 RRRLED-EPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPD 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 691 LPLMMGDSVMLEQLLLNLLKNAMEACASSnipmEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:COG4191  247 LPPVLGDPGQLEQVLLNLLINAIDAMEEG----EGGRITIST---RREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKP 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 512181387 771 --EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:COG4191  320 vgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
PAS COG2202
PAS domain [Signal transduction mechanisms];
324-569 3.86e-25

PAS domain [Signal transduction mechanisms];


:

Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 105.49  E-value: 3.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 324 RSHRTLMAEYSLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKPP--YPYWAKNYVAELTERLLSATN 401
Cdd:COG2202    1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRdlLPPEDDDEFLELLRAALAGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 402 HPEAEETLpvvtrfeaVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAV 481
Cdd:COG2202   81 VWRGELRN--------RRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 482 LAEPNRdvLFFANRSYRTLF------------------NDRPNGAAKLLARLEKAPPTVQSDGIF--DEETSRWFDVRSQ 541
Cdd:COG2202  153 LDLDGR--ILYVNPAAEELLgyspeellgkslldllhpEDRERLLELLRRLLEGGRESYELELRLkdGDGRWVWVEASAV 230

                        250       260
                 ....*....|....*....|....*...
gi 512181387 542 RIVWTRGETAVMVIATDITKRRELDLAR 569
Cdd:COG2202  231 PLRDGGEVIGVLGIVRDITERKRAEEAL 258
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 534-808 1.06e-55

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 195.79  E-value: 1.06e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 534 RWFDVRSQRIVWTRGETAVMVIATDITKRRELDLAR---EAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANAA 610
Cdd:COG4191   91 EALLLLLLAALDAEENAELEELERDITELERAEEELrelQEQLVQSE---KLAALGELAAGIAHEINNPLAAILGNAELL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 611 ATMLANgTLSKEREAQSYARIENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:COG4191  168 RRRLED-EPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPD 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 691 LPLMMGDSVMLEQLLLNLLKNAMEACASSnipmEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:COG4191  247 LPPVLGDPGQLEQVLLNLLINAIDAMEEG----EGGRITIST---RREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKP 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 512181387 771 --EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:COG4191  320 vgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 710-808 1.98e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 118.27  E-value: 1.98e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEACASSNIPMEERTIELHADpwekNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGG 789
Cdd:cd16920   10 RNGIEAMSEGGCERRELTIRTSPA----DDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGG 85

                         90
                 ....*....|....*....
gi 512181387 790 ELRMDPTPGGGSTFSFTVP 808
Cdd:cd16920   86 RLSVESPAGGGATFQFTLP 104
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
532-814 5.71e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 126.24  E-value: 5.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 532 TSRWFDVRSQRIvwtrgetAVMVIATDITKRRELdlarEAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANaaa 611
Cdd:PRK11360 351 TSLLHNTHGEMI-------GALVIFSDLTERKRL----QRRVARQE---RLAALGELVAGVAHEIRNPLTAIRGYVQ--- 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 612 tMLANGTlsKEREAQSY-ARIENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:PRK11360 414 -IWRQQT--SDPPSQEYlSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNE 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 691 LPLMMGDSVMLEQLLLNLLKNAMEAcassnIPMEertIELHADPWEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:PRK11360 491 LPPIWADPELLKQVLLNILINAVQA-----ISAR---GKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA 562

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 512181387 771 EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKEAV 814
Cdd:PRK11360 563 KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 334-800 5.58e-28

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 118.85  E-value: 5.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  334 SLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGqkppypywaKNyvaeltERLLS-ATNHPEAEETL--- 409
Cdd:TIGR02938   4 EAYRQTVDQAPLAISITDLKANILYANDAFTRITGYTKEEIIG---------KN------ESVLSnHTTPPEVYQALwgs 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  410 -----PVVTRFEAVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVeaANERFTL--VVESMASAIAVL 482
Cdd:TIGR02938  69 laeqkPWAGKLLNRRKDGELYLAELTVAPVLNEAGETTHFLGMHRDITELHRLEQVV--ANQKLLIesVVDAAPVAFVLL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  483 AEPNRDVLffANRSYRTLFND--------------RPNGAAKLLARLEKAPPTVQSDGIFD---EETSRWFDVRSQRI-- 543
Cdd:TIGR02938 147 DPTGRVIL--DNQEYKKLATDlrvkepahtvldllREAWREALAENWPQQLAFSNREARFDrggGRPARWLSCTGSVIgm 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  544 --------VWTRGETAVMVIATDIT---KRRELDLAREAQLRRAEStHRLVTMGEMASSLAHELNQPLAAIANYAnaaaT 612
Cdd:TIGR02938 225 esdcadsfFCAAEQPYLLLTIADISnlrEEQERARLSALQALMAEE-ERLEAIRETLSAAIHRLQGPMNLISAAI----S 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  613 MLANGTLSKEREAQsyARIENQAQRAGR-IIQRIRGFAKKTDAK-LEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:TIGR02938 300 VLQRRGDDAGNPAS--AAMLQQALSAGReHMEALRQVIPQSPQEiVVPVNLNQILRDVITLSTPRLLAAGIVVDWQPAAT 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  691 LPLMMGDSVMLEQLLLNLLKNAMEACASSNIpmeeRTIELHADPWEKNpERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:TIGR02938 378 LPAILGRELQLRSLFKALVDNAIEAMNIKGW----KRRELSITTALNG-DLIVVSILDSGPGIPQDLRYKVFEPFFTTKG 452

                         490       500       510
                  ....*....|....*....|....*....|...
gi 512181387  771 ---EGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:TIGR02938 453 gsrKHIGMGLSVAQEIVADHGGIIDLDDDYSEG 485
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 710-809 3.10e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 100.80  E-value: 3.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387   710 KNAMEACassnipMEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTK-----SEGMGMGLNICRSIA 784
Cdd:smart00387  15 DNAIKYT------PEGGRITVTL---ERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*
gi 512181387   785 ELHGGELRMDPTPGGGSTFSFTVPF 809
Cdd:smart00387  86 ELHGGEISVESEPGGGTTFTITLPL 110
PAS COG2202
PAS domain [Signal transduction mechanisms];
324-569 3.86e-25

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 105.49  E-value: 3.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 324 RSHRTLMAEYSLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKPP--YPYWAKNYVAELTERLLSATN 401
Cdd:COG2202    1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRdlLPPEDDDEFLELLRAALAGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 402 HPEAEETLpvvtrfeaVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAV 481
Cdd:COG2202   81 VWRGELRN--------RRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 482 LAEPNRdvLFFANRSYRTLF------------------NDRPNGAAKLLARLEKAPPTVQSDGIF--DEETSRWFDVRSQ 541
Cdd:COG2202  153 LDLDGR--ILYVNPAAEELLgyspeellgkslldllhpEDRERLLELLRRLLEGGRESYELELRLkdGDGRWVWVEASAV 230

                        250       260
                 ....*....|....*....|....*...
gi 512181387 542 RIVWTRGETAVMVIATDITKRRELDLAR 569
Cdd:COG2202  231 PLRDGGEVIGVLGIVRDITERKRAEEAL 258
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 711-809 1.31e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.20  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  711 NAMEACAssniPMEERTIELHADpweknpERLQFQVVDHGPGIPEESRSKLFDAFYS---TKSEGMGMGLNICRSIAELH 787
Cdd:pfam02518  16 NALKHAA----KAGEITVTLSEG------GELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLVELL 85

                          90       100
                  ....*....|....*....|..
gi 512181387  788 GGELRMDPTPGGGSTFSFTVPF 809
Cdd:pfam02518  86 GGTITVESEPGGGTTVTLTLPL 107
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 335-467 3.92e-16

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 75.41  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  335 LRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKP----PYPYWAKnyVAELTERLLSATNHPEAEEtlp 410
Cdd:TIGR00229   4 RYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVleliPEEDREE--VRERIERRLEGEPEPVSEE--- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387  411 vvtrFEAVRKNGEEFWAELRISPLLDDDGKPfGSIGALFDVTnsvlaqSRVEAANER 467
Cdd:TIGR00229  79 ----RRVRRKDGSEIWVEVSVSPIRTNGGEL-GVVGIVRDIT------ERKEAEEAL 124
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 353-452 1.72e-13

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 66.72  E-value: 1.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  353 KGRMLYVNDTFPKIVGYPAKELIGQKPPYPYWAKNYVAELtERLLSATNHPEAEEtlpvvtrFEAVRKNGEEFWAELRIS 432
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERL-REALREGKAVREFE-------VVLYRKDGEPFPVLVSLA 72

                          90       100
                  ....*....|....*....|
gi 512181387  433 PLLDDDGKPFGSIGALFDVT 452
Cdd:pfam13426  73 PIRDDGGELVGIIAILRDIT 92
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 325-473 3.53e-11

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 66.78  E-value: 3.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 325 SHRTLMAEYSLRRVMSESAVVGLRVTDLKGR---MLYVNDTFPKIVGYPAKELIGQKPPY---PYWAKNYVAELTERLls 398
Cdd:PRK13558 139 SDLTVESDRRLKERALDEAPVGITIADATLPdepLIYINDAFERITGYSPDEVLGRNCRFlqgEDTNEERVAELREAI-- 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512181387 399 atnhpEAEETLPVVTRfeAVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLVVE 473
Cdd:PRK13558 217 -----DEERPTSVELR--NYRKDGSTFWNQVDIAPIRDEDGTVTHYVGFQTDVTERKEAELALQRERRKLQRLLE 284
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 345-451 6.70e-11

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 59.95  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 345 VGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQkPPYPYWAKNYVAELTERLLSATNHPEaeetlPVVTRFEAVRKNGEE 424
Cdd:cd00130    3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGK-SLLDLIHPEDREELRERLENLLSGGE-----PVTLEVRLRRKDGSV 76

                         90       100
                 ....*....|....*....|....*..
gi 512181387 425 FWAELRISPLLDDDGKPFGSIGALFDV 451
Cdd:cd00130   77 IWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 337-401 1.14e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 40.85  E-value: 1.14e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512181387   337 RVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGqKPPYPYWAKNYVAELTERLLSATN 401
Cdd:smart00091   4 RAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIG-KSLLELIHPEDRERVQEALQRLLS 67
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 534-808 1.06e-55

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 195.79  E-value: 1.06e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 534 RWFDVRSQRIVWTRGETAVMVIATDITKRRELDLAR---EAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANAA 610
Cdd:COG4191   91 EALLLLLLAALDAEENAELEELERDITELERAEEELrelQEQLVQSE---KLAALGELAAGIAHEINNPLAAILGNAELL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 611 ATMLANgTLSKEREAQSYARIENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:COG4191  168 RRRLED-EPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPD 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 691 LPLMMGDSVMLEQLLLNLLKNAMEACASSnipmEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:COG4191  247 LPPVLGDPGQLEQVLLNLLINAIDAMEEG----EGGRITIST---RREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKP 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 512181387 771 --EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:COG4191  320 vgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
460-816 4.32e-50

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 180.43  E-value: 4.32e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 460 RVEAANERFTLVVESMASAIAVLAEpnRDVLFFANRSYRTLFNDRPN------------GAAKLLARLEKAPPTVQSdgI 527
Cdd:COG3852    1 ALRESEELLRAILDSLPDAVIVLDA--DGRITYVNPAAERLLGLSAEellgrplaelfpEDSPLRELLERALAEGQP--V 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 528 FDEETS--------RWFDVRSQRIVWTRGETAVMVIATDITKRRELdlarEAQLRRAEsthRLVTMGEMASSLAHELNQP 599
Cdd:COG3852   77 TEREVTlrrkdgeeRPVDVSVSPLRDAEGEGGVLLVLRDITERKRL----ERELRRAE---KLAAVGELAAGLAHEIRNP 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 600 LAaianyanaaaTMLANGTLSKER----EAQSYAR-IENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANI 674
Cdd:COG3852  150 LT----------GIRGAAQLLERElpddELREYTQlIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRA 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 675 QARKlDSRIKLVIAPGLPLMMGDS----------VmleqlllnllKNAMEACASS-NIPMEERTIELHADPWEKNPERLQ 743
Cdd:COG3852  220 EAPK-NIRIVRDYDPSLPEVLGDPdqliqvllnlV----------RNAAEAMPEGgTITIRTRVERQVTLGGLRPRLYVR 288

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512181387 744 FQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKEAVTH 816
Cdd:COG3852  289 IEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 324-808 3.61e-47

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 175.55  E-value: 3.61e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 324 RSHRTLMAEYSLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIgQKPPYPYWAKNYVAELTERLLSATNHP 403
Cdd:COG5809    5 KMELQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELL-GTNILDFLHPDDEKELREILKLLKEGE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 404 EAEETLpvvtrFEAVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAVLA 483
Cdd:COG5809   84 SRDELE-----FELRHKNGKRLEFSSKLSPIFDQNGDIEGMLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 484 EPNRdvLFFANRSYRTLFN--------------DRPNGAAKLLARLEKApptVQSDGIFDEE--------TSRWFDVRSQ 541
Cdd:COG5809  159 LDGR--IIYANPAACKLLGisieeligksilelIHSDDQENVAAFISQL---LKDGGIAQGEvrfwtkdgRWRLLEASGA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 542 RIVWTRGETAVMVIATDITKRRELdlarEAQLRRAEsthRLVTMGEMASSLAHELNQPLaaianyanaaaT-------ML 614
Cdd:COG5809  234 PIKKNGEVDGIVIIFRDITERKKL----EELLRKSE---KLSVVGELAAGIAHEIRNPL-----------TslkgfiqLL 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 615 ANGTLSKEREaqsYARI-ENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPGLPL 693
Cdd:COG5809  296 KDTIDEEQKT---YLDImLSELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPD 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 694 MMGDSVMLEQLLLNLLKNAMEACASS-NIpmeerTIELHAdpweKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEG 772
Cdd:COG5809  373 ILGDENQLKQVFINLLKNAIEAMPEGgNI-----TIETKA----EDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKG 443

                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 512181387 773 MGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:COG5809  444 TGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 444-814 3.13e-45

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 168.22  E-value: 3.13e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 444 SIGALFDVTNSV---LAQSR--VEAANERFTLVVESMASAIAVLAEPNRdvLFFANRSYRTLFNDRPNGAA-KLLARL-- 515
Cdd:COG5000   63 EIGELARAFNRMtdqLKEQReeLEERRRYLETILENLPAGVIVLDADGR--ITLANPAAERLLGIPLEELIgKPLEELlp 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 516 ---------EKAPPTVQSDGIFDEETSRWFDVRSQRIvwtRGETAVMVIaTDITkrreldlareaQLRRAEsthRLVTMG 586
Cdd:COG5000  141 eldlaellrEALERGWQEEIELTRDGRRTLLVRASPL---RDDGYVIVF-DDIT-----------ELLRAE---RLAAWG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 587 EMASSLAHELNQPLaaianyanaaaT----------MLANGTLSKERE--AQSYARIENQAQRAGRIIQRIRGFAKKTDA 654
Cdd:COG5000  203 ELARRIAHEIKNPL-----------TpiqlsaerlrRKLADKLEEDREdlERALDTIIRQVDRLKRIVDEFLDFARLPEP 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 655 KLEPVAVETVIQETLELANIQARKLDSRIKLVIAPGLPLMMGDSVMLEQLLLNLLKNAMEACAssnipmEERTIELHAdp 734
Cdd:COG5000  272 QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIE------EGGEIEVST-- 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 735 wEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKEAV 814
Cdd:COG5000  344 -RREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
570-808 3.37e-40

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 148.13  E-value: 3.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 570 EAQLRRAESTHRLvtMGEMASSLAHELNQPLAAIANYANaaaTMLANGTLSKEREAQSYARIENQAQRAGRIIQRIRGFA 649
Cdd:COG2205    3 EEALEELEELERL--KSEFLANVSHELRTPLTSILGAAE---LLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 650 K----KTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPGLPLMMGDSVMLEQLLLNLLKNAMEACAssnipmEE 725
Cdd:COG2205   78 RlesgKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSP------PG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 726 RTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFY----STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGS 801
Cdd:COG2205  152 GTITISA---RREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGT 228


                 ....*..
gi 512181387 802 TFSFTVP 808
Cdd:COG2205  229 TFTVTLP 235
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 347-808 6.64e-40

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 154.50  E-value: 6.64e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 347 LRVTDLKGRMLYVNDTFPKIVGYPAKELIGqKPPYPYWAKNYVAELTERLlsatnhpEAEETLPVVTRFEAVR-KNGEEF 425
Cdd:COG5805   47 IIAVNREGKVIYINPAMEKLLGYTSEEIIG-KTIFDFLEKEYHYRVKTRI-------ERLQKGYDVVMIEQIYcKDGELI 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 426 WAELRISPLLDDDGKPfgSIGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAVLAEPNRdvLFFANRSYRTLFndrp 505
Cdd:COG5805  119 YVEVKLFPIYNQNGQA--AILALRDITKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGR--ILFINESIERLF---- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 506 nGAAKLLARLEKAPPTVQSDgiFDEETSRWFDVRSQ----------------RIVWTR-----------GETAVMVIATD 558
Cdd:COG5805  191 -GAPREELIGKNLLELLHPC--DKEEFKERIESITEvwqefiiereiitkdgRIRYFEavivplidtdgSVKGILVILRD 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 559 ITKRRELdlarEAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYAnaaaTMLANGtlsKEREAQSYARIENQAQRA 638
Cdd:COG5805  268 ITEKKEA----EELMARSE---KLSIAGQLAAGIAHEIRNPLTSIKGFL----QLLQPG---IEDKEEYFDIMLSELDRI 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 639 GRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPGLPLMMGDSVMLEQLLLNLLKNAMEAcas 718
Cdd:COG5805  334 ESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEA--- 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 719 snipME-ERTIELHADPWEknpERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGGELRMDPTP 797
Cdd:COG5805  411 ----MPnGGTITIHTEEED---NSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKV 483

                        490
                 ....*....|.
gi 512181387 798 GGGSTFSFTVP 808
Cdd:COG5805  484 GKGTTFTITLP 494
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
534-808 1.07e-34

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 135.42  E-value: 1.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 534 RWFDVRSQRIVWTRGETAVMVIATDITKRRELDLAREAQLRRAESTHRLvtMGEMASSLAHELNQPLAAIANYANaaatM 613
Cdd:COG0642   61 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA--KSRFLANVSHELRTPLTAIRGYLE----L 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 614 LANGTLSKEREAqsYARIENQAQRAGRIIQRIRGFAK----KTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAP 689
Cdd:COG0642  135 LLEELDEEQREY--LETILRSADRLLRLINDLLDLSRleagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPD 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 690 GLPLMMGDSVMLEQLLLNLLKNAMEACAssnipmEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTK 769
Cdd:COG0642  213 DLPTVRGDPDRLRQVLLNLLSNAIKYTP------EGGTVTVSV---RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD 283

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 512181387 770 S----EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:COG0642  284 PsrrgGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
445-812 2.10e-32

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 130.06  E-value: 2.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 445 IGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAVLAEPNRDVLFFANRSYRTLFNDRPNGAAKLLARLEKAPPTVQS 524
Cdd:COG5002   41 LLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 525 DGIFDEETSRWFDVRSQRIVWTRGETAVMVIATDITKRRELDlareaQLRRaesthrlvtmgEMASSLAHELNQPLaaia 604
Cdd:COG5002  121 LSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLE-----QMRR-----------EFVANVSHELRTPL---- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 605 nyanaaaT-------MLANGTLSKEREAQSY-ARIENQAQRAGRIIQRI----RGFAKKTDAKLEPVAVETVIQETLELA 672
Cdd:COG5002  181 -------TsirgyleLLLDGAADDPEERREYlEIILEEAERLSRLVNDLldlsRLESGELKLEKEPVDLAELLEEVVEEL 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 673 NIQARKLDSRIKLVIAPGLPLMMGD-----SVMLeqlllnllkNAME-ACASSNipmEERTIELHadpWEKNPERLQFQV 746
Cdd:COG5002  254 RPLAEEKGIELELDLPEDPLLVLGDpdrleQVLT---------NLLDnAIKYTP---EGGTITVS---LREEDDQVRISV 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 512181387 747 VDHGPGIPEESRSKLFDAFY------STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKE 812
Cdd:COG5002  319 RDTGIGIPEEDLPRIFERFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 710-808 1.98e-31

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 118.27  E-value: 1.98e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEACASSNIPMEERTIELHADpwekNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGG 789
Cdd:cd16920   10 RNGIEAMSEGGCERRELTIRTSPA----DDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGG 85

                         90
                 ....*....|....*....
gi 512181387 790 ELRMDPTPGGGSTFSFTVP 808
Cdd:cd16920   86 RLSVESPAGGGATFQFTLP 104
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
532-814 5.71e-30

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 126.24  E-value: 5.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 532 TSRWFDVRSQRIvwtrgetAVMVIATDITKRRELdlarEAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANaaa 611
Cdd:PRK11360 351 TSLLHNTHGEMI-------GALVIFSDLTERKRL----QRRVARQE---RLAALGELVAGVAHEIRNPLTAIRGYVQ--- 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 612 tMLANGTlsKEREAQSY-ARIENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:PRK11360 414 -IWRQQT--SDPPSQEYlSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNE 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 691 LPLMMGDSVMLEQLLLNLLKNAMEAcassnIPMEertIELHADPWEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:PRK11360 491 LPPIWADPELLKQVLLNILINAVQA-----ISAR---GKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKA 562

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 512181387 771 EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKEAV 814
Cdd:PRK11360 563 KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 559-792 2.23e-29

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 124.41  E-value: 2.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 559 ITKRRELDL------AREAQLRRAES----THRLVTMGEMASSLAHELNQPLAAIANYANAAATMLANGtlSKEREAQSY 628
Cdd:COG4192  397 IEKTQELETeieerkRIEKNLRQTQDeliqAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQE--NYAQLPTSL 474

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 629 ARIENQAQRAGRIIQRIRGFAKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLviaPGLPLMMGDSVMLEQLLLNL 708
Cdd:COG4192  475 DKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHI---PDDLMVQGDQVLLEQVLVNL 551

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 709 LKNAMEACAssnipmEERTIELHadpWEKNPERLQFQVVDHGPGIPeeSRSKLFDAFYSTKSEGMGMGLNICRSIAELHG 788
Cdd:COG4192  552 LVNALDAVA------TQPQISVD---LLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFG 620


                 ....
gi 512181387 789 GELR 792
Cdd:COG4192  621 GDLY 624
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 334-800 5.58e-28

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 118.85  E-value: 5.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  334 SLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGqkppypywaKNyvaeltERLLS-ATNHPEAEETL--- 409
Cdd:TIGR02938   4 EAYRQTVDQAPLAISITDLKANILYANDAFTRITGYTKEEIIG---------KN------ESVLSnHTTPPEVYQALwgs 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  410 -----PVVTRFEAVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVeaANERFTL--VVESMASAIAVL 482
Cdd:TIGR02938  69 laeqkPWAGKLLNRRKDGELYLAELTVAPVLNEAGETTHFLGMHRDITELHRLEQVV--ANQKLLIesVVDAAPVAFVLL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  483 AEPNRDVLffANRSYRTLFND--------------RPNGAAKLLARLEKAPPTVQSDGIFD---EETSRWFDVRSQRI-- 543
Cdd:TIGR02938 147 DPTGRVIL--DNQEYKKLATDlrvkepahtvldllREAWREALAENWPQQLAFSNREARFDrggGRPARWLSCTGSVIgm 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  544 --------VWTRGETAVMVIATDIT---KRRELDLAREAQLRRAEStHRLVTMGEMASSLAHELNQPLAAIANYAnaaaT 612
Cdd:TIGR02938 225 esdcadsfFCAAEQPYLLLTIADISnlrEEQERARLSALQALMAEE-ERLEAIRETLSAAIHRLQGPMNLISAAI----S 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  613 MLANGTLSKEREAQsyARIENQAQRAGR-IIQRIRGFAKKTDAK-LEPVAVETVIQETLELANIQARKLDSRIKLVIAPG 690
Cdd:TIGR02938 300 VLQRRGDDAGNPAS--AAMLQQALSAGReHMEALRQVIPQSPQEiVVPVNLNQILRDVITLSTPRLLAAGIVVDWQPAAT 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  691 LPLMMGDSVMLEQLLLNLLKNAMEACASSNIpmeeRTIELHADPWEKNpERLQFQVVDHGPGIPEESRSKLFDAFYSTKS 770
Cdd:TIGR02938 378 LPAILGRELQLRSLFKALVDNAIEAMNIKGW----KRRELSITTALNG-DLIVVSILDSGPGIPQDLRYKVFEPFFTTKG 452

                         490       500       510
                  ....*....|....*....|....*....|...
gi 512181387  771 ---EGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:TIGR02938 453 gsrKHIGMGLSVAQEIVADHGGIIDLDDDYSEG 485
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 312-808 2.32e-27

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 117.19  E-value: 2.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 312 IGLVFYYQRQQVRSHRTLMAEYSLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKPPYPYWAKNYVAE 391
Cdd:COG4251    1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 392 LTERLLSATNHPEAEETLPVVTRFEAVRKNGEEFWAELRISpLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLV 471
Cdd:COG4251   81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLL-LLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 472 VESMASAIAVLAEPNRDVLFFANRSYRTLFNDRPNGAAKLLARLEKAPPTVQSDGIFDEETSRWFDVRSQRIVWTR---- 547
Cdd:COG4251  160 LLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLvlll 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 548 -GETAVMVIATDITKRRELDLAREAQLRRAESTHRLVT----MGEMASSLAHELNQPLAaianyanaaaTMLANGTLSKE 622
Cdd:COG4251  240 lLILLLLLLILVLELLELRLELEELEEELEERTAELERsneeLEQFAYVASHDLREPLR----------KISGFSQLLEE 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 623 R-------EAQSY-ARIENQAQRAGRIIQRIRGFAK--KTDAKLEPVAVETVIQETLElaNIQARKLDSRIKLVIAPgLP 692
Cdd:COG4251  310 DygdkldeEGREYlERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELLEEVLE--DLEPRIEERGAEIEVGP-LP 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 693 LMMGDSVMLEQLLLNLLKNAMEACASSNIPmeerTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFY----ST 768
Cdd:COG4251  387 TVRGDPTLLRQVFQNLISNAIKYSRPGEPP----RIEIGA---EREGGEWVFSVRDNGIGIDPEYAEKIFEIFQrlhsRD 459

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|
gi 512181387 769 KSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:COG4251  460 EYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 710-809 3.10e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 100.80  E-value: 3.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387   710 KNAMEACassnipMEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTK-----SEGMGMGLNICRSIA 784
Cdd:smart00387  15 DNAIKYT------PEGGRITVTL---ERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*
gi 512181387   785 ELHGGELRMDPTPGGGSTFSFTVPF 809
Cdd:smart00387  86 ELHGGEISVESEPGGGTTFTITLPL 110
PAS COG2202
PAS domain [Signal transduction mechanisms];
324-569 3.86e-25

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 105.49  E-value: 3.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 324 RSHRTLMAEYSLRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKPP--YPYWAKNYVAELTERLLSATN 401
Cdd:COG2202    1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRdlLPPEDDDEFLELLRAALAGGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 402 HPEAEETLpvvtrfeaVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAV 481
Cdd:COG2202   81 VWRGELRN--------RRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 482 LAEPNRdvLFFANRSYRTLF------------------NDRPNGAAKLLARLEKAPPTVQSDGIF--DEETSRWFDVRSQ 541
Cdd:COG2202  153 LDLDGR--ILYVNPAAEELLgyspeellgkslldllhpEDRERLLELLRRLLEGGRESYELELRLkdGDGRWVWVEASAV 230

                        250       260
                 ....*....|....*....|....*...
gi 512181387 542 RIVWTRGETAVMVIATDITKRRELDLAR 569
Cdd:COG2202  231 PLRDGGEVIGVLGIVRDITERKRAEEAL 258
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 727-809 7.15e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 96.79  E-value: 7.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 727 TIELHADPWEKNPERLQFQVVDHGPGIPEESRSKLFDAF------YSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:cd16922   22 TLRVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAISKKLVELMGGDISVESEPGQG 101


                 ....*....
gi 512181387 801 STFSFTVPF 809
Cdd:cd16922  102 STFTFTLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 711-809 1.31e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.20  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  711 NAMEACAssniPMEERTIELHADpweknpERLQFQVVDHGPGIPEESRSKLFDAFYS---TKSEGMGMGLNICRSIAELH 787
Cdd:pfam02518  16 NALKHAA----KAGEITVTLSEG------GELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLVELL 85

                          90       100
                  ....*....|....*....|..
gi 512181387  788 GGELRMDPTPGGGSTFSFTVPF 809
Cdd:pfam02518  86 GGTITVESEPGGGTTVTLTLPL 107
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
570-808 2.20e-21

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 98.32  E-value: 2.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 570 EAQLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANAAATMLANGTlskerEAQSYARI-ENQAQRAGRIIQRIRGF 648
Cdd:PRK10364 225 QDEMKRKE---KLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGG-----EAHQLAQVmAKEADRLNRVVSELLEL 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 649 AKKTDAKLEPVAVETVIQETLELANIQARKLDSRIKLVIAPGLPLMMGDSVMLEQLLLNLLKNAMEAcassnIPmEERTI 728
Cdd:PRK10364 297 VKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQA-----IG-QHGVI 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 729 ELHADpWEKnpERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK10364 371 SVTAS-ESG--AGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 466-812 5.98e-20

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 92.99  E-value: 5.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 466 ERFTLVVESMASAIAVLAEPNRDVLffANRSYRTLFNDRPNGAakllaRLEKAPPTVQSDGIFDEETS---RWFDVRSQR 542
Cdd:COG3290   84 EEREAVLESIREGVIAVDRDGRITL--INDAARRLLGLDAIGR-----PIDEVLAEVLETGERDEEILlngRVLVVNRVP 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 543 IVWTRGETAVMVIATDITKRRELdlarEAQLRRAESthrlvtMGEMASSLAHELNQPLAaianyanaaaTMLANGTLSKE 622
Cdd:COG3290  157 IRDDGRVVGAVATFRDRTELERL----EEELEGVKE------LAEALRAQRHDFRNHLH----------TISGLLQLGEY 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 623 REAQSYarIENQAQRAGRIIQRIRgfakktdAKLEPVAVETVIQETLELANiqarklDSRIKLVIAPglplmmgDSVMLE 702
Cdd:COG3290  217 DEALEY--IDEISEELQELIDSLL-------SRIGNPVLAALLLGKAARAR------ERGIDLTIDI-------DSDLPD 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 703 QLLLNLL---------KNAMEACAssNIPMEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTK-SEG 772
Cdd:COG3290  275 LPLSDTDlvtilgnllDNAIEAVE--KLPEEERRVELSI---RDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEG 349

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 512181387 773 MGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKE 812
Cdd:COG3290  350 RGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 728-808 1.24e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 78.91  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 728 IELHadpWEKNPERLQFQVVDHGPGIPEESRSKLFDAFY----STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTF 803
Cdd:cd16921   24 IEVG---AEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQrlhsREEYEGTGVGLAIVRKIIERHGGRIWLESEPGEGTTF 100


                 ....*
gi 512181387 804 SFTVP 808
Cdd:cd16921  101 YFTLP 105
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
445-808 9.21e-17

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 85.11  E-value: 9.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 445 IGALFDVTNSVLAQSRVEAANERFTLVVESMASAIAVLAEPNRDVLF-FANRSYRTLFNDRpngaAKLLARLEKAPP--- 520
Cdd:PRK13837 282 ISRCFEAASPHELEASIEAALGILAKFFDADSAALALVDVGGRARIWtFPGLTPDPVWPDR----LRALASTVKAAErdv 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 521 -------TVQSDGIFDEETSR-W----------------FDVRSQRIVWTRGETAVMVIATDI----TKRRELDLAREAQ 572
Cdd:PRK13837 358 vfvdrngPVRKRSCLTRRGPAlWaclafksgdrivallgLGRQRYGLRPPAGELQLLELALDClahaIERRRLETERDAL 437

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 573 LRRAESTHRLVTMGEMASSLAHELNQPLAAIANYANAAATMLANGTlskeREAQSYARIENQAQRAGRIIQRIRGFAKKT 652
Cdd:PRK13837 438 ERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHS----RAARYIDEIISAGARARLIIDQILAFGRKG 513

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 653 DAKLEPVAVETVIQETLEL--ANIQAR---KLDSRIKLVIAPGLPLMMGDSVMLEQlllnllKNAMEAC-ASSNIPMEER 726
Cdd:PRK13837 514 ERNTKPFDLSELVTEIAPLlrVSLPPGvelDFDQDQEPAVVEGNPAELQQVLMNLC------SNAAQAMdGAGRVDISLS 587

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 727 TIELHAdpweknPERL-----------QFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGGELRMDP 795
Cdd:PRK13837 588 RAKLRA------PKVLshgvlppgryvLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQS 661

                        410
                 ....*....|...
gi 512181387 796 TPGGGSTFSFTVP 808
Cdd:PRK13837 662 TVGRGTRFDVYLP 674
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 335-467 3.92e-16

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 75.41  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  335 LRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKP----PYPYWAKnyVAELTERLLSATNHPEAEEtlp 410
Cdd:TIGR00229   4 RYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVleliPEEDREE--VRERIERRLEGEPEPVSEE--- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387  411 vvtrFEAVRKNGEEFWAELRISPLLDDDGKPfGSIGALFDVTnsvlaqSRVEAANER 467
Cdd:TIGR00229  79 ----RRVRRKDGSEIWVEVSVSPIRTNGGEL-GVVGIVRDIT------ERKEAEEAL 124
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 591-808 4.37e-16

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 81.81  E-value: 4.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 591 SLAHELNQPLAAIANYANaaatmLANGTLSKEREAQSYARIENQAQRAGRIIQRIRGFAK----KTDAKLEPVAVETVIQ 666
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAE-----LLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARleqrQELEVLEPVALAALLE 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 667 ETLELANIQARKldSRIKLVIAPGLPLMMGDSVMLEQLLLNLLKNAMEAcasSNipmEERTIELHAdpwEKNPERLQFQV 746
Cdd:PRK11100 337 ELVEAREAQAAA--KGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDF---SP---EGGTITLSA---EVDGEQVALSV 405

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 512181387 747 VDHGPGIPEESRSKLFDAFYST-------KSEgmGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK11100 406 EDQGPGIPDYALPRIFERFYSLprpangrKST--GLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
PRK13557 PRK13557
histidine kinase; Provisional
 558-819 1.36e-15

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 80.49  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 558 DITKRREldlAREAqLRRAEsthRLVTMGEMASSLAHELNQPLAAIANYANAAATMLANGTLSKEREAQSYARIENQAQR 637
Cdd:PRK13557 143 DVSRRRD---AEDA-LRQAQ---KMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENIRAAAER 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 638 AGRIIQRIRGFAKKTdaKLE--PVAVETVIQETLELANiqaRKL--DSRIKLVIAPGLPLMMGDSVMLEQLLLNLLKNAM 713
Cdd:PRK13557 216 AATLTQQLLAFARKQ--RLEgrVLNLNGLVSGMGELAE---RTLgdAVTIETDLAPDLWNCRIDPTQAEVALLNVLINAR 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 714 EACAS-SNIPMEERTIELHAdpweknPERLQFQ-----------VVDHGPGIPEESRSKLFDAFYSTKSE--GMGMGLNI 779
Cdd:PRK13557 291 DAMPEgGRVTIRTRNVEIED------EDLAMYHglppgryvsiaVTDTGSGMPPEILARVMDPFFTTKEEgkGTGLGLSM 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 512181387 780 CRSIAELHGGELRMDPTPGGGSTFSFTVPFVKEAVTHAPS 819
Cdd:PRK13557 365 VYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAENPEQE 404
PRK09303 PRK09303
histidine kinase;
569-808 1.60e-15

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 79.22  E-value: 1.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 569 REAQLRRAESTHRLVTMgemassLAHELNQPLAAianyanaaaTMLANGTL-------SKEREAQSYARIENQAQRAGRI 641
Cdd:PRK09303 141 NETLLEQLKFKDRVLAM------LAHDLRTPLTA---------ASLALETLelgqideDTELKPALIEQLQDQARRQLEE 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 642 IQRI------RGFAKKTDAKLEP--VAVETVIQETLE--LANIQARKLdsRIKLVIAPGLPLMMGDS-----VMLeqlll 706
Cdd:PRK09303 206 IERLitdlleVGRTRWEALRFNPqkLDLGSLCQEVILelEKRWLAKSL--EIQTDIPSDLPSVYADQerirqVLL----- 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 707 nllkNAME-ACASSNipmEERTIE---LHadpweKNPERLQFQVVDHGPGIPEESRSKLFDAFY----STKSEGMGMGLN 778
Cdd:PRK09303 279 ----NLLDnAIKYTP---EGGTITlsmLH-----RTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLS 346

                        250       260       270
                 ....*....|....*....|....*....|
gi 512181387 779 ICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK09303 347 VCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 710-805 2.94e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 72.10  E-value: 2.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEACASsnipMEERTIELHADpWEKNpeRLQFQVVDHGPGIPEESRSKLFDAFYSTK--SEGMGMGLNICRSIAELH 787
Cdd:cd16976   10 QNALDAMGK----VENPRIRIAAR-RLGG--RLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVEEH 82

                         90
                 ....*....|....*...
gi 512181387 788 GGELRMDPTPGGGSTFSF 805
Cdd:cd16976   83 GGRLSVANEEGAGARFTF 100
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 711-808 5.15e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 71.55  E-value: 5.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 711 NAMEACASSNIPMEERTIELHADPWEknperLQFQVVDHGPGIPEESRSKLFDAFYSTKSEG-MGMGLNICRSIAELHGG 789
Cdd:cd16915   11 NALDALAATGAPNKQVEVFLRDEGDD-----LVIEVRDTGPGIAPELRDKVFERGVSTKGQGeRGIGLALVRQSVERLGG 85

                         90
                 ....*....|....*....
gi 512181387 790 ELRMDPTPGGGSTFSFTVP 808
Cdd:cd16915   86 SITVESEPGGGTTFSIRIP 104
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 710-808 1.34e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 70.51  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEACASSNIPMEERTIELHADPWEKNPERL--QFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELH 787
Cdd:cd16918   10 RNAAQALAGSGGEIILRTRTQRQVTLGHPRHRLalRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLAIAQNIVSQH 89

                         90       100
                 ....*....|....*....|.
gi 512181387 788 GGELRMDPTPgGGSTFSFTVP 808
Cdd:cd16918   90 GGVIECDSQP-GHTVFSVSLP 109
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 710-808 6.67e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 68.33  E-value: 6.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEACASSNIPMEERTIELHADpwekNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELHGG 789
Cdd:cd16944   14 KNAAEAIEGRPSDVGEVRIRVEAD----QDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEHGG 89

                         90
                 ....*....|....*....
gi 512181387 790 ELRMDPTPGGGSTFSFTVP 808
Cdd:cd16944   90 RISLSNREAGGACIRIILP 108
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 711-808 1.01e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 67.83  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 711 NAMEAcassnipMEER-TIELHADPWEknpERLQFQVVDHGPGIPEESRSKLFDAFYSTK--SEGMGMGLNICRSIAELH 787
Cdd:cd16943   14 NAAQA-------MEGRgRITIRTWAHV---DQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRIIQKH 83

                         90       100
                 ....*....|....*....|.
gi 512181387 788 GGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16943   84 GGTIRVASVPGGGTRFTIILP 104
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 353-452 1.72e-13

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 66.72  E-value: 1.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  353 KGRMLYVNDTFPKIVGYPAKELIGQKPPYPYWAKNYVAELtERLLSATNHPEAEEtlpvvtrFEAVRKNGEEFWAELRIS 432
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERL-REALREGKAVREFE-------VVLYRKDGEPFPVLVSLA 72

                          90       100
                  ....*....|....*....|
gi 512181387  433 PLLDDDGKPFGSIGALFDVT 452
Cdd:pfam13426  73 PIRDDGGELVGIIAILRDIT 92
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 738-808 4.06e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 65.91  E-value: 4.06e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387 738 NPERLQFQVVDHGPGIPEESRSKLFDAF------YSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16939   27 SGGRLTLIVEDDGPGIPAAARERVFEPFvrldpsRDRATGGFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWP 103
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 739-808 4.58e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 65.95  E-value: 4.58e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512181387 739 PERLQFQVVDHGPGIPEESRSKLFDAFYSTKSE------GMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16946   34 PQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 743-800 4.76e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 66.28  E-value: 4.76e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 512181387 743 QFQVVDHGPGIPEESRSKLFDAFY---STKSEGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:cd16940   46 VIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVKRIVELHGGQIFLGNAQGGG 106
PRK10490 PRK10490
sensor protein KdpD; Provisional
 740-808 9.20e-13

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 71.99  E-value: 9.20e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512181387 740 ERLQFQVVDHGPGIPEESRSKLFDAFYSTKSE----GMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK10490 809 ERLQLDVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 335-451 1.21e-12

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 65.13  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  335 LRRVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKPP--YPYWAKNYVAELTERLLSATNHPEAEETLPVV 412
Cdd:pfam00989   2 DLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLdlIPEEDDAEVAELLRQALLQGEESRGFEVSFRV 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 512181387  413 trfeavrKNGEEFWAELRISPLLDDDGKPFGSIGALFDV 451
Cdd:pfam00989  82 -------PDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
PRK15347 PRK15347
two component system sensor kinase;
740-809 1.86e-12

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 71.21  E-value: 1.86e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 512181387 740 ERLQFQVVDHGPGIPEESRSKLFDAFY--STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPF 809
Cdd:PRK15347 543 QQLCFTVEDTGCGIDIQQQQQIFTPFYqaDTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 738-800 1.54e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 61.31  E-value: 1.54e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387 738 NPERLQFQVVDHGPGIPEESRSKLFDAFY----STKSEGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:cd16950   27 EGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRISDAHGGSLTLANRAGGG 93
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 736-803 2.13e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 61.32  E-value: 2.13e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512181387 736 EKNPERLQFQVVDHGPGIPEESRSKLFDAFYS-----TKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTF 803
Cdd:cd16945   31 EADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQLHGGRITLRNRPDGVLAF 103
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 726-808 3.12e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 60.80  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 726 RTIELHadpWEKNPERLQFQVVDHGPGIPEESRSKLFDAFY------STKSEGMGMGLNICRSIAELHGGELRMDPTPGG 799
Cdd:cd16949   18 SKILLD---ISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERAIEQHGGKIKASNRKPG 94


                 ....*....
gi 512181387 800 GSTFSFTVP 808
Cdd:cd16949   95 GLRVRIWLP 103
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 325-473 3.53e-11

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 66.78  E-value: 3.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 325 SHRTLMAEYSLRRVMSESAVVGLRVTDLKGR---MLYVNDTFPKIVGYPAKELIGQKPPY---PYWAKNYVAELTERLls 398
Cdd:PRK13558 139 SDLTVESDRRLKERALDEAPVGITIADATLPdepLIYINDAFERITGYSPDEVLGRNCRFlqgEDTNEERVAELREAI-- 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512181387 399 atnhpEAEETLPVVTRfeAVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSVLAQSRVEAANERFTLVVE 473
Cdd:PRK13558 217 -----DEERPTSVELR--NYRKDGSTFWNQVDIAPIRDEDGTVTHYVGFQTDVTERKEAELALQRERRKLQRLLE 284
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 739-808 3.66e-11

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 60.58  E-value: 3.66e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512181387 739 PERLQFQVVDHGPGIPEESRSKLFDAFY------STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16925   35 LNRFLLTVSDSGPGIPPNLREEIFERFRqgdgssTRAHGGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 341-455 5.22e-11

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 60.12  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  341 ESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGqKPPYPYWAKNYVAELTERLlsatnhPEAEETLPVVTRFEAVRK 420
Cdd:pfam08448   2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLG-KTLAELLPPEDAARLERAL------RRALEGEEPIDFLEELLL 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 512181387  421 NGEEFWAELRISPLLDDDGKPFGSIGALFDVTNSV 455
Cdd:pfam08448  75 NGEERHYELRLTPLRDPDGEVIGVLVISRDITERR 109
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 345-451 6.70e-11

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 59.95  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 345 VGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQkPPYPYWAKNYVAELTERLLSATNHPEaeetlPVVTRFEAVRKNGEE 424
Cdd:cd00130    3 DGVIVLDLDGRILYANPAAEQLLGYSPEELIGK-SLLDLIHPEDREELRERLENLLSGGE-----PVTLEVRLRRKDGSV 76

                         90       100
                 ....*....|....*....|....*..
gi 512181387 425 FWAELRISPLLDDDGKPFGSIGALFDV 451
Cdd:cd00130   77 IWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PRK10604 PRK10604
sensor protein RstB; Provisional
 745-808 1.10e-10

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 64.62  E-value: 1.10e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 745 QVVDHGPGIPEESRSKLFDAFY------STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK10604 353 IVEDDGPGIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 711-809 1.81e-10

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 64.16  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 711 NAMEACASsnipMEERTIEL---HADPWeknperLQFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRSIAELH 787
Cdd:PRK11086 444 NALEAVGG----EEGGEISVslhYRNGW------LHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENL 513

                         90       100
                 ....*....|....*....|..
gi 512181387 788 GGELRMDPTPGGGSTFSFTVPF 809
Cdd:PRK11086 514 GGSIAVESEPGVGTQFFVQIPW 535
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 735-818 2.21e-10

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 64.19  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 735 WEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSE-------GMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFT- 806
Cdd:PRK11091 424 RYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTi 503

                         90
                 ....*....|...
gi 512181387 807 -VPFVKEAVTHAP 818
Cdd:PRK11091 504 hAPAVAEEVEDAF 516
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 735-808 8.87e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 56.83  E-value: 8.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 735 WEKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSE------GMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16952   26 WSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIErcrntgGTGLGLAIVKHVMSRHDARLLIASELGKGSRFTCLFP 105
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
558-808 1.05e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 62.44  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  558 DITKRRelDLAREAQLRRAESTHRLVTMGEMASSLAHELNQPLAAIANYANaaatMLANGTLSKEREAQSYARIENQAQR 637
Cdd:PRK09959  687 DITETR--DLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLE----LLSGSGLSKEQRVEAISLAYATGQS 760

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  638 AGRIIQRIRGFAK--KTDAKLEP--VAVETVIQETLE-LANIQARKldsRIKLVIAPGLP---LMMGDSVMLEQLLLNLL 709
Cdd:PRK09959  761 LLGLIGEILDVDKieSGNYQLQPqwVDIPTLVQNTCHsFGAIAASK---SIALSCSSTFPdhyLVKIDPQAFKQVLSNLL 837

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  710 KNAMEACASSNIPMEERTIELhadpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFYST----KSEGMGMGLNICRSIAE 785
Cdd:PRK09959  838 SNALKFTTEGAVKITTSLGHI-----DDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIK 912

                         250       260
                  ....*....|....*....|...
gi 512181387  786 LHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK09959  913 NMQGDLSLESHPGIGTTFTITIP 935
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
735-808 1.66e-09

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 60.79  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 735 WEKNPERLQFQVVDHGPGIPEESRSKLFDAFY------STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK11006 343 WQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 744-808 2.20e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 55.85  E-value: 2.20e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387 744 FQVVDHGPGIPEESRSKLFDAFYSTKSE--GMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16919   50 LEVSDTGSGMPAEVLRRAFEPFFTTKEVgkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 740-808 4.78e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 54.89  E-value: 4.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 512181387 740 ERLQFQVVDHGPGIPEESRSKLFDAFYSTKSEG------MGMGLNICRSIAELHGG----ELRMDPTPGGGSTFSFTVP 808
Cdd:cd16953   32 KMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQIIEAHGGisvaENHNQPGQVIGARFTVQLP 110
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
736-800 1.39e-08

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 58.11  E-value: 1.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 512181387 736 EKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTKSE------GMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:PRK10549 379 EQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGG 449
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 737-806 2.11e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 53.40  E-value: 2.11e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 512181387 737 KNPERLQFQVVDHGPGIPEESRSKLFD--AFYSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFT 806
Cdd:cd16954   63 QTDGGLHLIVDDDGPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVV 134
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 723-808 2.77e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 52.39  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 723 MEERTIELHADPWEKNperLQFQVVDHGPGIPEESRSKLFDAFY----STKSEGMGMGLNICRSIAELHGGELRMDpTPG 798
Cdd:cd16923   17 PENTRIYITSFLTDDV---VNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIELHGGSASAE-YDD 92

                         90
                 ....*....|
gi 512181387 799 GGSTFSFTVP 808
Cdd:cd16923   93 NHDLFKVRLP 102
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 742-809 1.32e-07

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 55.63  E-value: 1.32e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512181387 742 LQFQVVDHGPGIPEESRSKLFDAF------YSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPF 809
Cdd:PRK11107 445 LEVQIRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 736-808 1.52e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 50.36  E-value: 1.52e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512181387 736 EKNPERLQFQVVDHGPGIPEESRSKLFDAFYSTK-----SEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16948   32 ETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
envZ PRK09467
osmolarity sensor protein; Provisional
 738-800 1.70e-07

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 54.53  E-value: 1.70e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 512181387 738 NPERLQFQVVDHGPGIPEESRSKLFDAFysTK------SEGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:PRK09467 358 EGKRAWFQVEDDGPGIPPEQLKHLFQPF--TRgdsargSSGTGLGLAIVKRIVDQHNGKVELGNSEEGG 424
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 657-820 2.21e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 54.53  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 657 EPVAVETVIQETLELANIQARKLDSRIKLVIAPGLP-LMMGDSVMLEQLLLNLLKNAMEACASSNIPMEERTIELHadpW 735
Cdd:PRK11466 517 EPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPtALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQ---W 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 736 eknperlQFQVVDHGPGIPEESRSKLFDAFY--STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPF---- 809
Cdd:PRK11466 594 -------LVEVEDSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLrvat 666

                        170
                 ....*....|...
gi 512181387 810 --VKEAVTHAPSI 820
Cdd:PRK11466 667 apVPKTVNQAVRL 679
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
727-802 1.68e-06

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 51.12  E-value: 1.68e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512181387 727 TIELHADPweknpERLQFQVVDHGPGIPEESRSKLFDAF--YSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGGST 802
Cdd:PRK10755 270 TIKLSQED-----GGAVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGT 342
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
724-812 1.80e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 51.17  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 724 EERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFySTKSEGMGMGL-NICRSIAELHGGE--LRMDPTPGGG 800
Cdd:COG2972  358 GGGTIRISI---RKEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLrNVRERLKLYYGEEygLEIESEPGEG 433

                         90
                 ....*....|..
gi 512181387 801 STFSFTVPFVKE 812
Cdd:COG2972  434 TTVTIRIPLEEE 445
PRK10337 PRK10337
sensor protein QseC; Provisional
 744-800 1.82e-06

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 51.19  E-value: 1.82e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 512181387 744 FQVVDHGPGIPEESRSKLFDAFY----STKSeGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:PRK10337 383 FTVRDNGPGVTPEALARIGERFYrppgQEAT-GSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
742-808 2.49e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 51.13  E-value: 2.49e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512181387 742 LQFQVVDHGPGIPEESRSKLFDAFY------STKSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:PRK10841 594 LSFRVRDTGVGIPAKEVVRLFDPFFqvgtgvQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 710-802 2.49e-06

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 48.49  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEAcassnipmeerTIELHADPWEKNP----------ERLQFQVVDHGPGIPEESRSKLFDAFYSTKSE-------- 771
Cdd:cd16929   53 KNAMRA-----------TVESHGDDSDDLPpikvtvakgdEDLTIKISDRGGGIPREDLARLFSYMYSTAPQpslddfsd 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 512181387 772 -----------GMGMGLNICRSIAELHGGELRMDPTPGGGST 802
Cdd:cd16929  122 lisgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTD 163
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 304-473 3.47e-06

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 50.83  E-value: 3.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  304 LALMLLAA--IGLVFYYQRQQvRSHRTlMAEYSLRRVMSESAVvGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQkppy 381
Cdd:PRK09776  254 FLLILLPAniMTMVMYAFRAE-RKHIS-ESETRFRNAMEYSAI-GMALVGTEGQWLQVNKALCQFLGYSQEELRGL---- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  382 PYWAKNYVAELT------ERLLSA-TNHPEAEEtlpvvtRFeaVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVTNS 454
Cdd:PRK09776  327 TFQQLTWPEDLNkdlqqvEKLLSGeINSYSMEK------RY--YRRDGEVVWALLAVSLVRDTDGTPLYFIAQIEDINEL 398

                         170
                  ....*....|....*....
gi 512181387  455 VLAQSRVEAANERFTLVVE 473
Cdd:PRK09776  399 KRTEQVNERLMERITLANE 417
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 357-446 5.69e-06

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 45.41  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  357 LYVNDTFPKIVGYPAKELIGQKPPypyWAKNYVAELTERLLSAtnhpeAEETL----PVVTRFEAVRKNGEEFWAELRIS 432
Cdd:pfam08447   2 IYWSPRFEEILGYTPEELLGKGES---WLDLVHPDDRERVREA-----LWEALkggePYSGEYRIRRKDGEYRWVEARAR 73

                          90
                  ....*....|....
gi 512181387  433 PLLDDDGKPFGSIG 446
Cdd:pfam08447  74 PIRDENGKPVRVIG 87
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 724-801 9.41e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 45.15  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 724 EERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAFY----STKSEG-MGMGLNICRSIAELHGGELRMDPTPG 798
Cdd:cd16975   22 EGGTVSISI---YDEEEYLYFEIWDNGHGFSEQDLKKALELFYrddtSRRSGGhYGMGLYIAKNLVEKHGGSLIIENSQK 98


                 ...
gi 512181387 799 GGS 801
Cdd:cd16975   99 GGA 101
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 739-808 1.68e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 43.70  E-value: 1.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 739 PERLQFQVVDHGPGIPEESRSKlfdafystkseGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVP 808
Cdd:cd16917   29 ADELTLTVVDDGVGFDGPAPPG-----------GGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARLP 87
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 711-798 2.97e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 44.49  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 711 NAMEACAssNIPMEERTIELHADpweKNPERLQFQVVDHGPGIPEESRSKlfdaFYSTKSE-GMGMGLNICRSIAELHGG 789
Cdd:cd16935   47 NAIEACA--KIDKENRFIHLKIR---QKKGFLIISIENSYEGELKKKNGL----FLSTKKDkNHGIGLKSIREIVKKYNG 117


                 ....*....
gi 512181387 790 ELRMDPTPG 798
Cdd:cd16935  118 NLSIEYENG 126
PRK13559 PRK13559
hypothetical protein; Provisional
 356-519 4.16e-05

hypothetical protein; Provisional


Pssm-ID: 237427 [Multi-domain]  Cd Length: 361  Bit Score: 46.74  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 356 MLYVNDTFPKIVGYPAKELIGQKPPY---PYWAKNYVAELTERLlsatnhpEAEETlpVVTRFEAVRKNGEEFWAELRIS 432
Cdd:PRK13559  68 IVLANQAFLDLTGYAAEEVVGRNCRFlqgAATDPIAVAKIRAAI-------AAERE--IVVELLNYRKDGEPFWNALHLG 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 433 PLLDDDGKPFGSIGALFDVTNsVLAQSRVEAANERFTLVVE-------SMASAIAVLAEPNRDVLFFAN----------R 495
Cdd:PRK13559 139 PVYGEDGRLLYFFGSQWDVTD-IRAVRALEAHERRLAREVDhrsknvfAVVDSIVRLTGRADDPSLYAAaiqervqalaR 217

                        170       180
                 ....*....|....*....|....*.
gi 512181387 496 SYRTLFNDRPNGAAKL--LARLEKAP 519
Cdd:PRK13559 218 AHETLLDERGWETVEVeeLIRAQVAP 243
glnL PRK11073
nitrogen regulation protein NR(II);
710-808 5.39e-05

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 46.23  E-value: 5.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 710 KNAMEACASS--NIPMEERT---IELHADPWeknpeRL--QFQVVDHGPGIPEESRSKLFDAFYSTKSEGMGMGLNICRS 782
Cdd:PRK11073 247 RNALQALGPEggTITLRTRTafqLTLHGERY-----RLaaRIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARN 321

                         90       100
                 ....*....|....*....|....*.
gi 512181387 783 IAELHGGELRMDPTPgGGSTFSFTVP 808
Cdd:PRK11073 322 LIDQHSGKIEFTSWP-GHTEFSVYLP 346
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
746-812 9.77e-05

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 45.69  E-value: 9.77e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512181387 746 VVDHGPGIPEESRSKLFDAFYST------KSEGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVKE 812
Cdd:PRK09470 388 VDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKR 460
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 337-401 1.14e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 40.85  E-value: 1.14e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512181387   337 RVMSESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGqKPPYPYWAKNYVAELTERLLSATN 401
Cdd:smart00091   4 RAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIG-KSLLELIHPEDRERVQEALQRLLS 67
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
736-812 1.80e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 43.84  E-value: 1.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387 736 EKNPERLQFQVVDHGPGIPEESrsklfdafysTKSEGMGMgLNIcRSIAELHGGELRMDPTPGGGSTFSFTVPFVKE 812
Cdd:COG4585  188 EVDDGELTLTVRDDGVGFDPEA----------APGGGLGL-RGM-RERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 582-650 2.68e-04

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 39.89  E-value: 2.68e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 512181387 582 LVTMGEMASSLAHELNQPLaaiaNYANAAATMLANGTLSKEREAQSYARIENQAQRAGRIIQRIRGFAK 650
Cdd:cd00082    1 LQAKGEFLANVSHELRTPL----TAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
743-808 4.77e-04

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 43.61  E-value: 4.77e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512181387 743 QFQVVDHGPG--IPEESRSKLFDAFYST------KSEGMGMGLNICRSIAELHGGELRMDPTPgGGSTFSFTVP 808
Cdd:PRK09835 407 QVQLVVENPGtpIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 618-811 7.83e-04

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 42.90  E-value: 7.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 618 TLSKEREAQSYARI------ENQAQRAgrIIQRIRG-FAKKTDAKLEPVAVEtviqetlelaniQARKLDsrIKLVIAPG 690
Cdd:PRK15053 355 TLNGLLQMKEYDRVlemvqgESQAQQQ--LIDSLREaFADRQVAGLLFGKVQ------------RARELG--LKMVIVPG 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 691 -----LPLMMgDSVMLEQLLLNLLKNAMEAcaSSNIPMEERTIELHAdpwEKNPERLQFQVVDHGPGIPEESRSKLFDAF 765
Cdd:PRK15053 419 sqlsqLPPGL-DSTEFAAIVGNLLDNAFEA--SLRSDEGNKIVELFL---SDEGDDVVIEVADQGCGVPESLRDKIFEQG 492

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 512181387 766 YSTKSEG---MGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTVPFVK 811
Cdd:PRK15053 493 VSTRADEpgeHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVK 541
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 742-808 1.14e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 39.33  E-value: 1.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 742 LQFQVVDHGPGIPEESRSKLFDAFYSTKSeGMGMGL-NICRSIAELHGGE--LRMDPTPGGGSTFSFTVP 808
Cdd:cd16957   38 VHVSVSDNGQGIPEERLDLLGKTTVTSEK-GTGTALeNLNRRLIGLFGSEacLHIESEVHGGTEVWFVIP 106
PAC smart00086
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...
 415-452 1.45e-03

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.


Pssm-ID: 197509  Cd Length: 43  Bit Score: 37.16  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 512181387   415 FEAVRKNGEEFWAELRISPLLDDDGKPFGSIGALFDVT 452
Cdd:smart00086   4 YRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDIT 41
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
714-799 2.14e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 38.74  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 714 EACasSNI------PMEERTIELHadpWEKNPERLQFQVVDHGPGIPEESRSKLFDAfystkSEGMGMGLNICRSIAElh 787
Cdd:COG2172   41 EAV--TNAvrhaygGDPDGPVEVE---LELDPDGLEIEVRDEGPGFDPEDLPDPYST-----LAEGGRGLFLIRRLMD-- 108

                         90
                 ....*....|..
gi 512181387 788 ggELRMDPTPGG 799
Cdd:COG2172  109 --EVEYESDPGG 118
HATPase_Phy-like cd16932
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ...
 741-792 3.89e-03

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.


Pssm-ID: 340409 [Multi-domain]  Cd Length: 113  Bit Score: 38.02  E-value: 3.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 512181387 741 RLQFQVVDHGPGIPEESRSKLFDafystKSEGM---GMGLNICRSIAELHGGELR 792
Cdd:cd16932   48 HLEFRITHPGQGLPEELVQEMFE-----ENQWTtqeGLGLSISRKLVKLMNGDVR 97
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 746-807 4.67e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 37.88  E-value: 4.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512181387 746 VVDHGPGIPEESRSKLFDAFYSTKS------EGMGMGLNICRSIAELHGGELRMDPTPGGGSTFSFTV 807
Cdd:cd16947   57 IWDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
746-800 4.85e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 40.39  E-value: 4.85e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 512181387 746 VVDHGPGIPEESRSKLFD--AFYSTKSEGMGMGLNICRSIAELHGGELRMDPTPGGG 800
Cdd:PRK10815 413 VEDDGPGIPESKRELIFDrgQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGG 469
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 341-462 5.74e-03

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 40.14  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387 341 ESAVVGLRVTDLKGRMLYVNDTFPKIVGYPAKELIGQKPpypywaknyvaeltERLLSATNHPEAEET-LPVVTRFEAVR 419
Cdd:COG3829   18 DSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNV--------------TELIPNSPLLEVLKTgKPVTGVIQKTG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 512181387 420 KNGEEFwaELRISPLLdDDGKPFGSIGALFDVTNSVLAQSRVE 462
Cdd:COG3829   84 GKGKTV--IVTAIPIF-EDGEVIGAVETFRDITELKRLERKLR 123
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 711-794 7.51e-03

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 36.81  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512181387  711 NAMEACasSNIPmEERTIELHAdpWEKNpERLQFQVVDhgpgiPEESRSKLFDAFYSTKS--EGMGMGLNICRSIAELHG 788
Cdd:pfam14501  16 NAIEAC--SKID-DNRFIRLKI--REKQ-NFLIIRIEN-----TYEGELKFEGKLPSTKTkgDGHGIGLKSIRRIVKKYG 84


                  ....*.
gi 512181387  789 GELRMD 794
Cdd:pfam14501  85 GNLSTE 90
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 585-650 8.80e-03

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 35.62  E-value: 8.80e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512181387   585 MGEMASSLAHELNQPLAAIANYANaaatMLANGTLSkEREAQSYARIENQAQRAGRIIQRIRGFAK 650
Cdd:smart00388   2 KREFLANLSHELRTPLTAIRGYLE----LLLDTELS-EEQREYLETILREAERLLRLINDLLDLSR 62
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 585-650 9.23e-03

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 35.65  E-value: 9.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512181387  585 MGEMASSLAHELNQPLAAIANYANaaatMLANGTLSKEREaQSYARIENQAQRAGRIIQRIRGFAK 650
Cdd:pfam00512   2 KSEFLANLSHELRTPLTAIRGYLE----LLRDEKLDEEQR-EYLETILRSAERLLRLINDLLDLSR 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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