|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
1-1077 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 1669.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 1 MVPYFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHaqwkDIRKESGFRLFIGCRLSF----ID 76
Cdd:PRK05672 2 LPPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAA----EAAKELGLRLVIGAELSLgpdpDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 77 GTPDMVVYPRDRAAYGQLCRLLTEGkHRAAIKGECHLEWADLLFRAR-----------QFQIAVFPPDEDEPDFAARLTE 145
Cdd:PRK05672 78 GGPHLLVLARDREGYGRLSRLITRA-RLRAGKGEYRLDLDDLAEPAGghwailtgcrkGFVILALPYGGDAAALAALAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 146 IAQAAPGSVWLALTMPHQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAE 225
Cdd:PRK05672 157 LDAFFADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 226 RHLKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGADmIPPKVQGL 305
Cdd:PRK05672 237 RHLRSGAEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRYGPG-IPPKARAQ 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 306 INKELALIARLEYEPYFLTVYDIVTHAREKGILCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVD 385
Cdd:PRK05672 316 IEHELALIAELGYEGYFLTVHDIVRFARSQGILCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPPDIDVD 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 386 FEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVWGLSGGGIDRQHIRQAGLDPDN 465
Cdd:PRK05672 396 FEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQRLRQAGLDPES 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 466 PIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCIRKA 545
Cdd:PRK05672 476 PIPRRVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKVDVLALGMLSALHRA 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 546 FDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQGDM 625
Cdd:PRK05672 556 FDLIAEHR-----GRRLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRPGPIQGGM 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 626 VHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATFRKMGTIHTM 705
Cdd:PRK05672 631 VHPYLRRRNGQEPVTYPHP--------ELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAAWRRKGRLERL 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 706 EKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGFYAPAQIVRD 785
Cdd:PRK05672 703 RERLYDGMLARGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQPMGFYSPQQLVQD 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 786 AREHGVTVLPVDVNFSQWDNILEETPDVHLALRLGFRQIDGFSKRDTELLIADR-QEPYRTIEDMHRRLRLDRRAFTLLA 864
Cdd:PRK05672 783 ARRHGVEVLPVDVNASGWDATLEPLPDGGPAVRLGLRLVRGLGEEAAERIVAARaRGPFTSVEDLARRAGLDRRQLEALA 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 865 DADAFGSLDIDRRAALWAVRRLPnDETLPLFRAAAASelaqEPRTKLPEMAASEHVIADYETTRLSLKGHPLQYLREGLA 944
Cdd:PRK05672 863 DAGALRSLGGDRRQALWAAGAAA-TERLDLLPGAPAS----EAAPALPGMSEGELVAADYWTTGLSLDSHPLALLRPRLD 937
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 945 AEGVSTCRAVQEGADGRRMKVAGVVTVRQRPGSAKGVVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQRS 1024
Cdd:PRK05672 938 ARGVVSAAELLDVEDGRRVRVAGVVTHRQRPGTASGVTFLTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRVQNA 1017
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|...
gi 514146994 1025 lEGVVHLVAAKLQDRSAALIemsgreaqrliapsqmahhprnvRVMPNSRDFH 1077
Cdd:PRK05672 1018 -EGVRHLVADRLEDLSPLLG-----------------------GLRTRSRDFH 1046
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
2-1037 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1318.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 2 VPYFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQWKdirkESGFRLFIGCRLSFIDGTPD- 80
Cdd:COG0587 3 PSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAK----KAGIKPIIGCELYVAPGSRDd 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 ----MVVYPRDRAAYGQLCRLLTEGKHRAAIKGECHLEWADLLFRARQfQIAVFPPDE----------DEPDFAARLTEI 146
Cdd:COG0587 79 agyhLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEG-LIALSGCLAgevgqallagQYDEAEAALARL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 147 AQAAPGSVWLALTMPHQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAER 226
Cdd:COG0587 158 KDIFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAER 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 227 HLKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGADmIPPKVQGLI 306
Cdd:COG0587 238 YLKSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEG-IPEEYRERL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 307 NKELALIARLEYEPYFLTVYDIVTHAREKGI-LCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVD 385
Cdd:COG0587 317 EYELDVIEKMGFPGYFLIVWDFIRWARSNGIpVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSMPDIDID 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 386 FEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVWGLSGGGIDR---QHIRQAGLD 462
Cdd:COG0587 397 FCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKaleEEPELRELY 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 463 PDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCI 542
Cdd:COG0587 477 DSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGLRTLTVI 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 543 RKAFDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQ 622
Cdd:COG0587 557 RDALDLIKENR-----GIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYRPGPMQ 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 623 GDMVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATfRKMGTI 702
Cdd:COG0587 632 GGMVPPYIRRKHGREPVEYPHP--------ELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGK-KKKEEM 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 703 HTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGFYAPAQI 782
Cdd:COG0587 703 AKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQY 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 783 VRDAREHGVTVLPVDVNFSQWDNILEEtpdvHLALRLGFRQIDGFSKRDTELLIADRQE--PYRTIEDMHRRL---RLDR 857
Cdd:COG0587 783 VQEARRHGIEVLPPDVNESDWDFTVEP----GGAIRLGLGAIKGVGEAAAEAIVAAREEngPFTSLFDFCRRVdlrKLNK 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 858 RAFTLLADADAFGSLDIDRRAALWAVRRLP----------NDETLPLFRAAAASELAQEPRTKLPEMAASEHVIADYETT 927
Cdd:COG0587 859 RVLEALIKAGAFDSLGPNRRQLLWALEAALdaaqqaqkdkASGQLSLFGGAGDEEVAEPALPELPEWSEKEKLAAEKEAL 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 928 RLSLKGHPLQYLREGLAAEGVSTCRAVQEGADGRRMKVAGVVTVRQRPGSAKG--VVFLTIEDETGIANIVIWPKIMKVF 1005
Cdd:COG0587 939 GLYLSGHPLDLYREELRRLGVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGkrMAFVTLEDETGSIEVVVFPEVYERY 1018
|
1050 1060 1070
....*....|....*....|....*....|..
gi 514146994 1006 RREVMSARLIHIEGRIQRSlEGVVHLVAAKLQ 1037
Cdd:COG0587 1019 RRLLLEDRLLLVRGKVQRR-DGVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
11-998 |
3.08e-164 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 511.54 E-value: 3.08e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAhaqWKDIRKEsGFRLFIGCRLSFIDGTPD---------- 80
Cdd:TIGR00594 8 SDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEF---YKACKKA-GIKPIIGCEAYVAPGSRFdkkriskgke 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 ---MVVYPRDRAAYGQLCRLLT----EGKH-RAAIKgechlewADLLFRARQFQIAVFPPDEDEPDFAARLTEIAQAAPG 152
Cdd:TIGR00594 84 ayhLILLAKNNTGYRNLMKLSSlaylEGFYyKPRID-------KELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 153 SVW----------LALtMPHQGQDGRRA-ERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLE 221
Cdd:TIGR00594 157 ALKyqeifgddyyLEL-QDHGIPEQRVVnEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 222 KNAERHLKPPHEMVRLFRDYPEAIAAT---ADFVAPITFQLDElkYAYPDEPIPPGKTAQQH-LYDLVWEGAARHYGADM 297
Cdd:TIGR00594 236 YSDEFYLKSPEEMAELFADIPEALANTveiAERCNLVDVKLGP--PRLPSYQIPPDFTSQEDyLRHLADEGLRERLAAGP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 298 ----IPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGI-LCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFI 372
Cdd:TIGR00594 314 pgykRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIpVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 373 SAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLS---EDVTAALANTVWGLSGG 449
Cdd:TIGR00594 394 NPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPyaeADRIAKLIPPRPGKTLK 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 450 GIDRQHIRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLM 529
Cdd:TIGR00594 474 EALEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 530 KVDVLSLGMLTCIRKAFDLIH-QHKPqlyggeKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYD 608
Cdd:TIGR00594 554 KMDFLGLKTLTLIQDATELIRkRRGI------DLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFED 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 609 LVIEVAIVRPGPIQGDMVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQ 688
Cdd:TIGR00594 628 IIAVNALYRPGPMESGMIPDFIDRKHGREPIEYPHP--------LLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADL 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 689 LRRAMATfRKMGTIHTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAAL 768
Cdd:TIGR00594 700 LRRAMGK-KKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAAL 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 769 LNSQPMGFYAPAQIVRDAREHGVTVLPVDVNFSQWDNILEETpdvhlALRLGFRQIDGFSKRDTELLIADRQE--PYRTI 846
Cdd:TIGR00594 779 LTSEINDIEKVAVYIAEAKKMGIEVLPPDINESGQDFAVEDK-----GIRYGLGAIKGVGESVVKSIIEERNKngPFKSL 853
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 847 EDMHRRL---RLDRRAFTLLADADAFGSLDIDRRA-------ALWAVRRLPNDETL---PLFRAAAASELAQEPRTKLPE 913
Cdd:TIGR00594 854 FDFINRVdfkKLNKKVLEALIKAGAFDSLGPNRKTllaslddALDAVSRKKKAEALgqnSLFGALSEGTKPEYVFFPPDE 933
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 914 MAASEHVIA-DYETTRLSLKGHPLQYLREGLAAEGVSTCRAVQEGADGRRMKVAGV---VTVRQRPGSAKGVVFLTIEDE 989
Cdd:TIGR00594 934 EWPDKKLLAlEKETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGlnsVKKKITTKNGKPMAFLQLEDE 1013
|
....*....
gi 514146994 990 TGIANIVIW 998
Cdd:TIGR00594 1014 TGSIEVVVF 1022
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
4-267 |
2.73e-126 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 385.27 E-value: 2.73e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 4 YFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQWKDIrkesGFRLFIGCRLSFIDGtPDMVV 83
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVRAHAAAKEL----GLKLIVGSELVLADG-TRLVL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 84 YPRDRAAYGQLCRLLTEGKHRAAiKGECHLEWADLLFRARQFQIAVFPPDEDEP--DFAARLTEIAQAAPGSVWLALTMP 161
Cdd:cd07434 76 LARDRAGYGRLCRLITLGRRRAE-KGEYRLTLADLLAHAEGLLLILLPPDRLPAaaALLAQLRWLARAFPGRLWLALELH 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 162 HQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAERHLKPPHEMVRLFRDY 241
Cdd:cd07434 155 LGGDDARRLARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEAGRRLAANAERHLRSPAELARLFLYP 234
|
250 260
....*....|....*....|....*.
gi 514146994 242 PEAIAATADFVAPITFQLDELKYAYP 267
Cdd:cd07434 235 PEALAETLEIAARCTFSLDELRYEYP 260
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
279-534 |
2.36e-119 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 367.21 E-value: 2.36e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 279 QHLYDLVWEGAARHYGaDMIPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGILC-QGRGSAANSVVCFCLGIT 357
Cdd:pfam07733 1 EYLRKLVEEGLKERYG-EGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVgPGRGSAAGSLVAYLLGIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 358 GVNPTQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTA 437
Cdd:pfam07733 80 EVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEID 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 438 ALANTVWGLSG--GGIDRQHIRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSF 515
Cdd:pfam07733 160 RLAKLIPFELGilEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKADDDDRPV 239
|
250
....*....|....*....
gi 514146994 516 IEWDKDDIDEVGLMKVDVL 534
Cdd:pfam07733 240 TQFDKDDLEDLGLLKMDFL 258
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
11-70 |
2.83e-08 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 51.50 E-value: 2.83e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQwkdiRKESGFRLFIGC 70
Cdd:smart00481 6 SDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKA----AKKAGIKPIIGL 61
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
1-1077 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 1669.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 1 MVPYFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHaqwkDIRKESGFRLFIGCRLSF----ID 76
Cdd:PRK05672 2 LPPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAA----EAAKELGLRLVIGAELSLgpdpDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 77 GTPDMVVYPRDRAAYGQLCRLLTEGkHRAAIKGECHLEWADLLFRAR-----------QFQIAVFPPDEDEPDFAARLTE 145
Cdd:PRK05672 78 GGPHLLVLARDREGYGRLSRLITRA-RLRAGKGEYRLDLDDLAEPAGghwailtgcrkGFVILALPYGGDAAALAALAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 146 IAQAAPGSVWLALTMPHQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAE 225
Cdd:PRK05672 157 LDAFFADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 226 RHLKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGADmIPPKVQGL 305
Cdd:PRK05672 237 RHLRSGAEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRYGPG-IPPKARAQ 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 306 INKELALIARLEYEPYFLTVYDIVTHAREKGILCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVD 385
Cdd:PRK05672 316 IEHELALIAELGYEGYFLTVHDIVRFARSQGILCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPPDIDVD 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 386 FEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVWGLSGGGIDRQHIRQAGLDPDN 465
Cdd:PRK05672 396 FEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQRLRQAGLDPES 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 466 PIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCIRKA 545
Cdd:PRK05672 476 PIPRRVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKVDVLALGMLSALHRA 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 546 FDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQGDM 625
Cdd:PRK05672 556 FDLIAEHR-----GRRLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRPGPIQGGM 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 626 VHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATFRKMGTIHTM 705
Cdd:PRK05672 631 VHPYLRRRNGQEPVTYPHP--------ELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAAWRRKGRLERL 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 706 EKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGFYAPAQIVRD 785
Cdd:PRK05672 703 RERLYDGMLARGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQPMGFYSPQQLVQD 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 786 AREHGVTVLPVDVNFSQWDNILEETPDVHLALRLGFRQIDGFSKRDTELLIADR-QEPYRTIEDMHRRLRLDRRAFTLLA 864
Cdd:PRK05672 783 ARRHGVEVLPVDVNASGWDATLEPLPDGGPAVRLGLRLVRGLGEEAAERIVAARaRGPFTSVEDLARRAGLDRRQLEALA 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 865 DADAFGSLDIDRRAALWAVRRLPnDETLPLFRAAAASelaqEPRTKLPEMAASEHVIADYETTRLSLKGHPLQYLREGLA 944
Cdd:PRK05672 863 DAGALRSLGGDRRQALWAAGAAA-TERLDLLPGAPAS----EAAPALPGMSEGELVAADYWTTGLSLDSHPLALLRPRLD 937
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 945 AEGVSTCRAVQEGADGRRMKVAGVVTVRQRPGSAKGVVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQRS 1024
Cdd:PRK05672 938 ARGVVSAAELLDVEDGRRVRVAGVVTHRQRPGTASGVTFLTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRVQNA 1017
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|...
gi 514146994 1025 lEGVVHLVAAKLQDRSAALIemsgreaqrliapsqmahhprnvRVMPNSRDFH 1077
Cdd:PRK05672 1018 -EGVRHLVADRLEDLSPLLG-----------------------GLRTRSRDFH 1046
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
2-1037 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1318.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 2 VPYFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQWKdirkESGFRLFIGCRLSFIDGTPD- 80
Cdd:COG0587 3 PSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAK----KAGIKPIIGCELYVAPGSRDd 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 ----MVVYPRDRAAYGQLCRLLTEGKHRAAIKGECHLEWADLLFRARQfQIAVFPPDE----------DEPDFAARLTEI 146
Cdd:COG0587 79 agyhLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEG-LIALSGCLAgevgqallagQYDEAEAALARL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 147 AQAAPGSVWLALTMPHQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAER 226
Cdd:COG0587 158 KDIFGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAER 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 227 HLKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGADmIPPKVQGLI 306
Cdd:COG0587 238 YLKSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEG-IPEEYRERL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 307 NKELALIARLEYEPYFLTVYDIVTHAREKGI-LCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVD 385
Cdd:COG0587 317 EYELDVIEKMGFPGYFLIVWDFIRWARSNGIpVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSMPDIDID 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 386 FEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVWGLSGGGIDR---QHIRQAGLD 462
Cdd:COG0587 397 FCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKaleEEPELRELY 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 463 PDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCI 542
Cdd:COG0587 477 DSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGLRTLTVI 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 543 RKAFDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQ 622
Cdd:COG0587 557 RDALDLIKENR-----GIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYRPGPMQ 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 623 GDMVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATfRKMGTI 702
Cdd:COG0587 632 GGMVPPYIRRKHGREPVEYPHP--------ELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGK-KKKEEM 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 703 HTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGFYAPAQI 782
Cdd:COG0587 703 AKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQY 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 783 VRDAREHGVTVLPVDVNFSQWDNILEEtpdvHLALRLGFRQIDGFSKRDTELLIADRQE--PYRTIEDMHRRL---RLDR 857
Cdd:COG0587 783 VQEARRHGIEVLPPDVNESDWDFTVEP----GGAIRLGLGAIKGVGEAAAEAIVAAREEngPFTSLFDFCRRVdlrKLNK 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 858 RAFTLLADADAFGSLDIDRRAALWAVRRLP----------NDETLPLFRAAAASELAQEPRTKLPEMAASEHVIADYETT 927
Cdd:COG0587 859 RVLEALIKAGAFDSLGPNRRQLLWALEAALdaaqqaqkdkASGQLSLFGGAGDEEVAEPALPELPEWSEKEKLAAEKEAL 938
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 928 RLSLKGHPLQYLREGLAAEGVSTCRAVQEGADGRRMKVAGVVTVRQRPGSAKG--VVFLTIEDETGIANIVIWPKIMKVF 1005
Cdd:COG0587 939 GLYLSGHPLDLYREELRRLGVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGkrMAFVTLEDETGSIEVVVFPEVYERY 1018
|
1050 1060 1070
....*....|....*....|....*....|..
gi 514146994 1006 RREVMSARLIHIEGRIQRSlEGVVHLVAAKLQ 1037
Cdd:COG0587 1019 RRLLLEDRLLLVRGKVQRR-DGVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
11-998 |
3.08e-164 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 511.54 E-value: 3.08e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAhaqWKDIRKEsGFRLFIGCRLSFIDGTPD---------- 80
Cdd:TIGR00594 8 SDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEF---YKACKKA-GIKPIIGCEAYVAPGSRFdkkriskgke 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 ---MVVYPRDRAAYGQLCRLLT----EGKH-RAAIKgechlewADLLFRARQFQIAVFPPDEDEPDFAARLTEIAQAAPG 152
Cdd:TIGR00594 84 ayhLILLAKNNTGYRNLMKLSSlaylEGFYyKPRID-------KELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 153 SVW----------LALtMPHQGQDGRRA-ERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLE 221
Cdd:TIGR00594 157 ALKyqeifgddyyLEL-QDHGIPEQRVVnEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 222 KNAERHLKPPHEMVRLFRDYPEAIAAT---ADFVAPITFQLDElkYAYPDEPIPPGKTAQQH-LYDLVWEGAARHYGADM 297
Cdd:TIGR00594 236 YSDEFYLKSPEEMAELFADIPEALANTveiAERCNLVDVKLGP--PRLPSYQIPPDFTSQEDyLRHLADEGLRERLAAGP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 298 ----IPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGI-LCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFI 372
Cdd:TIGR00594 314 pgykRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIpVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 373 SAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLS---EDVTAALANTVWGLSGG 449
Cdd:TIGR00594 394 NPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPyaeADRIAKLIPPRPGKTLK 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 450 GIDRQHIRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLM 529
Cdd:TIGR00594 474 EALEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 530 KVDVLSLGMLTCIRKAFDLIH-QHKPqlyggeKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYD 608
Cdd:TIGR00594 554 KMDFLGLKTLTLIQDATELIRkRRGI------DLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFED 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 609 LVIEVAIVRPGPIQGDMVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQ 688
Cdd:TIGR00594 628 IIAVNALYRPGPMESGMIPDFIDRKHGREPIEYPHP--------LLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADL 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 689 LRRAMATfRKMGTIHTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAAL 768
Cdd:TIGR00594 700 LRRAMGK-KKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAAL 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 769 LNSQPMGFYAPAQIVRDAREHGVTVLPVDVNFSQWDNILEETpdvhlALRLGFRQIDGFSKRDTELLIADRQE--PYRTI 846
Cdd:TIGR00594 779 LTSEINDIEKVAVYIAEAKKMGIEVLPPDINESGQDFAVEDK-----GIRYGLGAIKGVGESVVKSIIEERNKngPFKSL 853
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 847 EDMHRRL---RLDRRAFTLLADADAFGSLDIDRRA-------ALWAVRRLPNDETL---PLFRAAAASELAQEPRTKLPE 913
Cdd:TIGR00594 854 FDFINRVdfkKLNKKVLEALIKAGAFDSLGPNRKTllaslddALDAVSRKKKAEALgqnSLFGALSEGTKPEYVFFPPDE 933
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 914 MAASEHVIA-DYETTRLSLKGHPLQYLREGLAAEGVSTCRAVQEGADGRRMKVAGV---VTVRQRPGSAKGVVFLTIEDE 989
Cdd:TIGR00594 934 EWPDKKLLAlEKETLGLYVSGHPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGGlnsVKKKITTKNGKPMAFLQLEDE 1013
|
....*....
gi 514146994 990 TGIANIVIW 998
Cdd:TIGR00594 1014 TGSIEVVVF 1022
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
175-1022 |
1.38e-145 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 465.90 E-value: 1.38e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 175 RFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAERHLKPPHEMVRLFRDYPEAIAATADFVAP 254
Cdd:PRK06826 193 KLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDDENRMRFPSDEFYLKSPEEMYELFSYVPEALENTVKIAER 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 255 ITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGAdmIPPKVQGLINKELALIARLEYEPYFLTVYDIVTHARE 334
Cdd:PRK06826 273 CNVEFEFGKSKLPKFPLPEGYDPYEYLRELCYEGLKKRYPN--PSEELIERLEYELSVIKQMGYVDYFLIVWDFIRFARE 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 335 KGILC-QGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATV 413
Cdd:PRK06826 351 NGIMVgPGRGSAAGSLVAYTLGITKIDPIKYNLLFERFLNPERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITF 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 414 ISYRSRSAIRDVGKALGLSE---DVTAALANTVWGLSgggIDRqhirqA-GLDPD-------NPIIQRAVELAITLIGFP 482
Cdd:PRK06826 431 GTMAARAAIRDVGRALNYPYaevDRIAKMIPTELGIT---IDK-----AlELNPElkeayenDERVRELIDTARALEGLP 502
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 483 RHLSQHVGGFVLTRDRLDETVPIGPAamDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCIRKAFDLIHQHKpqlygGEKL 562
Cdd:PRK06826 503 RHASTHAAGVVISSEPLVEYVPLQKN--DGSIVTQFTMTTLEELGLLKMDFLGLRTLTVIRDAVDLIKKNR-----GIEI 575
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 563 TLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIqgDMVHPYLRRRSGQEPCTLP 642
Cdd:PRK06826 576 DLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFMKELKPDSLEDIIAGISLYRPGPM--DSIPRYIKNKNNPEKIEYL 653
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 643 SPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATfRKMGT--------IHTMEKKMIDGMV 714
Cdd:PRK06826 654 HP--------KLEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSDLVRRAMSK-KKHDVmeeerknfIYGIVDEGGPGCI 724
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 715 NRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNS-----QPMGFYapaqiVRDAREH 789
Cdd:PRK06826 725 RNGIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYYPVEFMAALLNSvmgnsDKVAFY-----IEECRRL 799
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 790 GVTVLPVDVNFSQWDNILEETpdvhlALRLGFRQIDGFSKRDTELLIADRQE--PYRTIEDMHRRL---RLDRRAFTLLA 864
Cdd:PRK06826 800 GIEVLPPDINESYSKFTVEGD-----KIRFGLAAVKNVGENAIDSIVEEREKkgKFKSLVDFCERVdtsQINKRAVESLI 874
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 865 DADAFGSLDIdRRAALWAV-----------RRLPNDETLPLFRAAAASElAQEPRTKLP---EMAASEHVIADYETTRLS 930
Cdd:PRK06826 875 KAGAFDSLGV-YRSQLLAVyekildsiskqRKKNIEGQISLFDLIGEEE-ESSLEIKYPdikEFDKKELLAMEKEMLGLY 952
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 931 LKGHPLQYLREGLAAegVSTCRAVQ-----------EGADGRRMKVAGVVTVRQRPGSAKGVV--FLTIEDETGIANIVI 997
Cdd:PRK06826 953 ISGHPLEEYEETLKK--QTSATISDiisdeeedgesKLKDGDKVIIGGIITEVKRKTTRNNEMmaFLTLEDLYGTVEVIV 1030
|
890 900
....*....|....*....|....*
gi 514146994 998 WPKIMKVFRREVMSARLIHIEGRIQ 1022
Cdd:PRK06826 1031 FPKVYEKYRSLLNEDNIVLIKGRVS 1055
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
11-1038 |
1.27e-137 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 444.16 E-value: 1.27e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAhaqWKDIRKEsGFRLFIGCRL----------SFIDGTPD 80
Cdd:PRK05673 9 SEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEF---YKAAKGA-GIKPIIGCEAyvapekkddvSGGGAYTH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 MVVYPRDRAAYGQLCRLL----TEG--KHRAAIKGECHLEWAD--------------LLFRARQFQIAVfppdedepDFA 140
Cdd:PRK05673 85 LTLLAKNETGYRNLFKLSsrayLEGqyGYKPRIDREWLAEHSEglialsgcpsgevgTALLAGQYDEAE--------EAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 141 ARLTEIAqaaPGSVWLALtMPHQGQDGRRAER-IARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTAtrhhttvFAAGRL 219
Cdd:PRK05673 157 AEYQEIF---GDRFYLEL-MRHGLPIERRVEHaLLELAKELGLPLVATNDVHYLTPEDAEAHEALLC-------IAEGKT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 220 L-EKNAERH------LKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARH 292
Cdd:PRK05673 226 LdDPDRFRFyspeqyLKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEEDYLRKEAKEGLEER 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 293 YGAdmIPPKVQGLINKElaliaRLEYE---------P-YFLTVYDIVTHAREKGILC-QGRGSAANSVVCFCLGITGVNP 361
Cdd:PRK05673 306 LAF--LFPDEERPEYVE-----RLEYEldviiqmgfPgYFLIVADFIQWAKDNGIPVgPGRGSGAGSLVAYALGITDLDP 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 362 TQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRaaiVATVISY---RSRSAIRDVGKALGLS----ED 434
Cdd:PRK05673 379 LRFGLLFERFLNPERVSMPDFDIDFCQDRRDEVIRYVAEKYGRDA---VAQIITFgtmKAKAVIRDVGRVLGMPygfvDR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 435 VTAALANTVwglsggGIDrqhIRQA-GLDPD-------NPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIg 506
Cdd:PRK05673 456 ITKLIPPDP------GIT---LAKAyEEEPElrelyesDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPL- 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 507 paAMDKRS-FI--EWDKDDIDEVGLMKVDVLSLGMLTCIRKAFDLIHQHkpqlyGGEKLTLASLPRKDKAVYDMLCKGDS 583
Cdd:PRK05673 526 --YRDPDSgMPvtQFDMKDVEAAGLVKFDFLGLRTLTIIDDALKLIKKR-----RGIDVDLEAIPLDDPKTYELLQRGET 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 584 LGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQGDMVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKG 663
Cdd:PRK05673 599 LGVFQLESRGMRDLLKRLKPDCFEDIIALVALYRPGPMESGMIPNFIDRKHGREEIEYPHP--------ELEPILKETYG 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 664 VPLFQEQAMRIAMEAAKFTPEEANQLRRAMAtfRKmgtIHT-MEK---KMIDGMVNRGYDRTFAENCFNQIKGFGEYGFP 739
Cdd:PRK05673 671 IIVYQEQVMQIAQVLAGYSLGGADLLRRAMG--KK---KPEeMAKqreIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFN 745
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 740 ESHAASFAHLVYISAWLKCHHPEVFAAALLNSQ-----PMGFYapaqiVRDAREHGVTVLPVDVNFSQwdniLEETPDVH 814
Cdd:PRK05673 746 KSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDmdntdKVAVY-----LDECRRMGIKVLPPDVNESL----YDFTVVDG 816
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 815 lALRLGFRQIDGFSKRDTELLIADRQE--PYRTIEDMHRRL---RLDRRAFTLLADADAFGSLDIDRRA-------ALWA 882
Cdd:PRK05673 817 -DIRYGLGAIKGVGEGAVEAIVEAREEggPFKDLFDFCARVdlkKVNKRVLESLIKAGAFDSLGPNRAAllasledAVDA 895
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 883 VRRLPNDETL---PLFraAAASELAQEPRTKLPEMAA-SEHVIADYE--TTRLSLKGHPLQYLREGLAAEGVSTCRAVQE 956
Cdd:PRK05673 896 ADQHKKAEASgqfDLF--GGLGEEPEDVEVSVPDVEEwDKKEKLAGEreTLGLYLSGHPLDGYEDELRRLRDTRLADLEP 973
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 957 GADGRRMKVAGVVTVRQRPGSAKG--VVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQRSlEGVVHLVAA 1034
Cdd:PRK05673 974 TEGGSVVTVAGLVVSVRRRVTKRGnkMAIVTLEDLSGRIEVMLFSEALEKYRDLLEEDRIVVVKGQVSFD-DGGLRLTAR 1052
|
....
gi 514146994 1035 KLQD 1038
Cdd:PRK05673 1053 EVMD 1056
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
4-267 |
2.73e-126 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 385.27 E-value: 2.73e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 4 YFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQWKDIrkesGFRLFIGCRLSFIDGtPDMVV 83
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVRAHAAAKEL----GLKLIVGSELVLADG-TRLVL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 84 YPRDRAAYGQLCRLLTEGKHRAAiKGECHLEWADLLFRARQFQIAVFPPDEDEP--DFAARLTEIAQAAPGSVWLALTMP 161
Cdd:cd07434 76 LARDRAGYGRLCRLITLGRRRAE-KGEYRLTLADLLAHAEGLLLILLPPDRLPAaaALLAQLRWLARAFPGRLWLALELH 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 162 HQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAERHLKPPHEMVRLFRDY 241
Cdd:cd07434 155 LGGDDARRLARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEAGRRLAANAERHLRSPAELARLFLYP 234
|
250 260
....*....|....*....|....*.
gi 514146994 242 PEAIAATADFVAPITFQLDELKYAYP 267
Cdd:cd07434 235 PEALAETLEIAARCTFSLDELRYEYP 260
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
2-1022 |
1.84e-119 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 394.55 E-value: 1.84e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 2 VPYFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVrahaQWKDIRKESGFRLFIGCRLS-FIDGTPD 80
Cdd:PRK06920 1 MKFVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVI----PFYKACKKHGIHPIIGLTASiFSEEEEK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 ---MVVYPRDRAAYGQLCRLLT--EGKHRAAIKGEchleWadlLFRARQFQIAVFP-------------PDEDEPDFAAR 142
Cdd:PRK06920 77 sypLVLLAENEIGYQNLLKISSsiMTKSKEGIPKK----W---LAHYAKGLIAISPgkdgeieqllledKESQAEEVARA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 143 LTEIAqaAPGSVWLALtMPHQGqDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEK 222
Cdd:PRK06920 150 YQNMF--GNFYMSLQH-HAIQD-ELLLQEKLPEFSNRVNIPVVATNDVRYINQSDALVHECLLSVESGTKMTDPDRPRLK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 223 NAERHLKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGAdmiPPKV 302
Cdd:PRK06920 226 TDQYYLKSSDEMEALFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETADMYLRRVCEEGLQKRYGT---PKEV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 303 Q-GLINKELALIARLEYEPYFLTVYDIVTHAREKGILC-QGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPP 380
Cdd:PRK06920 303 HiNRLNHELNVISRMGFSDYFLIVWDFMKYAHENHILTgPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLP 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 381 DIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVWGLSGGGIDRQHIRQAG 460
Cdd:PRK06920 383 DIDIDFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIPSKLGITLKDAYEESQS 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 461 LDP---DNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIgPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLG 537
Cdd:PRK06920 463 LREfiqGNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAI-QEGHNDVYVTQYPADALEELGLLKMDFLGLR 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 538 MLTCIRKAFDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVR 617
Cdd:PRK06920 542 NLTLLENIIKFIEQKT-----GKEIDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSLYR 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 618 PGPIQGdmVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMAtfR 697
Cdd:PRK06920 617 PGPMEQ--IPTFIESKHGKRKIEYLHP--------DLKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAVS--K 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 698 KMGTIHTMEKK-MIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGF 776
Cdd:PRK06920 685 KNRDILDQERKhFVQGCLQNGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNE 764
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 777 YAPAQIVRDAREHGVTVLPVDVNFSQWDNILEETpdvhlALRLGFRQIDGFSKRDTELLIADRQE-PYRTIEDMHRRL-- 853
Cdd:PRK06920 765 DKIVQYIRETKRKGFHVLPPSLQRSGYNFQIEGN-----AIRYSLLSIRNIGMATVTALYEEREKkMFEDLFEFCLRMps 839
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 854 -RLDRRAFTLLADADAFGSLDIDrRAALWAVRRLpndetlplfrAAAASELAQEPRTKLP--------EMAASEHVIADY 924
Cdd:PRK06920 840 kFVTERNLEAFVWSGCFDDFGVS-RTNLWKSLKG----------ALEYANLARDLGDAVPkskyvqgeELSFIEQLNKEK 908
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 925 ETTRLSLKGHPLQYLREGLAAEG-VSTCRAVQEGADGRRMKV--AGVVTVRQRPGsaKGVVFLTIEDETGIANIVIWPKI 1001
Cdd:PRK06920 909 EVLGFYLSSYPTAQYVKLAKELEiPSLAQAMRHKKKVQRAIVyiTSVKVIRTKKG--QKMAFITFCDQNDEMEAVVFPET 986
|
1050 1060
....*....|....*....|.
gi 514146994 1002 MKVFRREVMSARLIHIEGRIQ 1022
Cdd:PRK06920 987 YIHFSDKLQEGAIVLVDGTIE 1007
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
279-534 |
2.36e-119 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 367.21 E-value: 2.36e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 279 QHLYDLVWEGAARHYGaDMIPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGILC-QGRGSAANSVVCFCLGIT 357
Cdd:pfam07733 1 EYLRKLVEEGLKERYG-EGLPEEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVgPGRGSAAGSLVAYLLGIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 358 GVNPTQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTA 437
Cdd:pfam07733 80 EVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEID 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 438 ALANTVWGLSG--GGIDRQHIRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSF 515
Cdd:pfam07733 160 RLAKLIPFELGilEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKADDDDRPV 239
|
250
....*....|....*....
gi 514146994 516 IEWDKDDIDEVGLMKVDVL 534
Cdd:pfam07733 240 TQFDKDDLEDLGLLKMDFL 258
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
11-1000 |
5.80e-112 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 375.22 E-value: 5.80e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVrahaQWKDIRKESGFRLFIGCRLSFIDGTPD---------- 80
Cdd:PRK07374 10 SDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAI----ELLKLCKGKGIKPIIGNEMYVINGSIDdpqpkkekry 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 -MVVYPRDRAAYGQLCRLLT-------EGK---HRAAIKGECHLEWADLLFRARQFQIAVFPPD--EDEPDFAARLTEIA 147
Cdd:PRK07374 86 hLVVLAKNATGYKNLVKLTTishlngmRGRgifSRPCIDKELLKQYSEGLIVSTACLGGEIPQAilRGRPDVARDVAAWY 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 148 QAAPGS-VWLALtmphqgQD-GRRAERIA-----RFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLL 220
Cdd:PRK07374 166 KEVFGDdFYLEI------QDhGSIEDRIVnvelvRIAKELGIKLIATNDAHYLSKNDVEAHDALLCVLTGKLISDEKRLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 221 EKNAErHLKPPHEMVRLFRDY------PEAIAATADfVAPITFQLDEL-KYAYPDEPIPPGKTAQQHLYDLVWEGAARHY 293
Cdd:PRK07374 240 YTGTE-YIKSEEEMLRLFRDHldpeviQEAIANTVE-VAEKVEEYDILgTYRMPRFPIPEGHTAVSYLTEVTEQGLLKRL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 294 G---ADMIPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGI-LCQGRGSAANSVVCFCLGITGVNPTQVDLLFE 369
Cdd:PRK07374 318 KlnsLDEIDENYKERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIpVGPGRGSAAGSLVAYALGITNIDPVKNGLLFE 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 370 RFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLS---EDVTAALANTVWG- 445
Cdd:PRK07374 398 RFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPygeADRLAKLIPVVRGk 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 446 ---LSgggidrQHIRQAGLDPD-------NPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIgPAAMDKRSF 515
Cdd:PRK07374 478 pakLK------AMIGKESPSPEfrekyekDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPL-QRNNDGQVI 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 516 IEWDKDDIDEVGLMKVDVLSLGMLTCIRKAFDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQM 595
Cdd:PRK07374 551 TQYFMEDIESLGLLKMDFLGLKNLTMIEKTLELVEQST-----GERIDPDNLPLDDEKTFELLARGDLEGIFQLESSGMR 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 596 NMLPRLRPQEFYDLVIEVAIVRPGPIQGDMVHPYLRRRSGQEPCTLPSPSpqhgpaneLQQILGKTKGVPLFQEQAMRIA 675
Cdd:PRK07374 626 QVVRDLKPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFAHPL--------LEPILTETYGIMVYQEQIMKIA 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 676 MEAAKFTPEEANQLRRAMATFRkmgtIHTMEKK---MIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYI 752
Cdd:PRK07374 698 QDLAGYSLGQADLLRRAMGKKK----VSEMQKHrgiFVEGASKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQ 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 753 SAWLKCHHPEVFAAALLNSQPMGFYAPAQIVRDAREHGVTVLPVDVNFSQWDNileeTPDVHLALrLGFRQIDGFSKRDT 832
Cdd:PRK07374 774 TAYLKAHYPVAYMAALLTVNAGSSDKVQRYISNCNSMGIEVMPPDINRSGIDF----TPKGNRIL-FGLSAVKNLGDGAI 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 833 ELLIADRQE--PYRTIEDMHRRLR---LDRRAFTLLADADAFGSLDID-RRAAL---------WAVRRlPNDETL---PL 894
Cdd:PRK07374 849 RNIIAARDSdgPFKSLADLCDRLPsnvLNRRSLESLIHCGALDAFSPNaNRAQLiadldlvldWASSR-ARDRASgqgNL 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 895 FRAAAASElaqEPRTKLPEMAASEHVIADYETT---RLS-------LKGHPLQYLREG---LAAEGVSTcraVQEGADGR 961
Cdd:PRK07374 928 FDLLAGSE---EEASNDLSSAPKAAPVPDYPPTeklKLEkellgfyLSDHPLKQLTEPaklLAPISLSS---LEEQPDKA 1001
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 514146994 962 RMKVAGVVTVRQRPGSAKG--VVFLTIEDETGIANIVIWPK 1000
Cdd:PRK07374 1002 KVSAIAMIPEMKQVTTRKGdrMAILQLEDLTGSCEAVVFPK 1042
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
26-1041 |
2.41e-94 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 323.91 E-value: 2.41e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 26 VERAHALDLSGIGIADRNTLagvvraHAQWKDIR--KESGFRLFIGCRLSFIDGTPDMVVY--PRDRAAYGQLCRLLTeg 101
Cdd:PRK07279 24 VERAKELGYQTIGIMDKDNL------YGAYHFIEgaQKNGLQPILGLELNIFVEEQEVTLRliAKNTQGYKNLLKIST-- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 102 khrAAIKGEchLEWADLlfraRQF--QIAVFPPDEDEPDFAArlteiaqaAPGSVWLALTMPHQGQDGRRaeriarfaaq 179
Cdd:PRK07279 96 ---AKMSGK--KQFSDL----SQYleGIAVIVPYFDWSETLE--------LPFDYYIGVDQETPGSDFKR---------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 180 agvPLIATNDVLY-HHPDRRPLQdVLTATRHHTTvFAAGRLLEKNaeRHLKPPHEMVRLFRDY-PEAIAATADFVAPITF 257
Cdd:PRK07279 149 ---PILPLRTVRYfESADRETLQ-MLHAIRDNLS-LREVPLVSSD--QELISCQSLETLFQERfPQALDNLEKLVSGISY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 258 QLDE-LKYAYPDEPIPpgktAQQHLYDLVWEGAArhygADMIPPKV-QGLINKELALIARLEYEPYFLTVYDIVTHAREK 335
Cdd:PRK07279 222 DFDTdLKLPRFNRDRP----AVEELRELAELGLK----EKGLWSSPyQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQ 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 336 GILC-QGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVI 414
Cdd:PRK07279 294 GYYMgMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFS 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 415 SYRSRSAIRDVGKALGLSEdvtAALANTVWGLSGGGI------DRQHIRQagldpdnpII------QRAVELAITLIGFP 482
Cdd:PRK07279 374 TFGAKQAIRDVFKRFGVPE---YELSNLTKKISFRDSlasvyeKNISFRQ--------IInskleyQKAFEIAKRIEGNP 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 483 RHLSQHVGGFVLTRDRLDETVPIGPAamDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCIRKAFDLIHQHKpqlygGEKL 562
Cdd:PRK07279 443 RQTSIHAAGVVMSDDDLTNHIPLKYG--DDMMITQYDAHAVEANGLLKMDFLGLRNLTFVQKMQEKVAKDY-----GIHI 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 563 TLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPiqGDMVHPYLRRRSGQEPCTLP 642
Cdd:PRK07279 516 DIEAIDLEDKETLALFAAGDTKGIFQFEQPGAINLLKRIKPVCFEDIVATTSLNRPGA--SDYTDNFVKRRHGQEKVDLI 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 643 SPSpqhgpaneLQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATfRKMGTIHTMEKKMIDGMVNRGYDRTF 722
Cdd:PRK07279 594 DPV--------IAPILEPTYGIMLYQEQVMQIAQVFAGFSLGKADLLRRAMSK-KNASEMQKMEEDFLQGALELGHSEEK 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 723 AENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNsqpmgfYAPAQIVRDAREHGVTVLPVDVNFSQ 802
Cdd:PRK07279 665 ARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMLN------YSSSDYITDALEFGFEVAKLSINTIP 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 803 WDNILEETpdvhlALRLGFRQIDGFSkRDTELLIADRQePYRTIEDMHRRL--RLDRRAF-TLLADADAFGSLDIDRRAA 879
Cdd:PRK07279 739 YHDKIENK-----KIYLGLKNIKGLP-RDLAYWIIENR-PFSSIEDFLTRLpeNYQKKEFlEPLIKIGLFDSFEKNRQKI 811
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 880 LwavRRLPN-----DETLPLFRAAAASELAQEprtklpEMAASEHVIADYETTRLSLKGHPLQylreGLAAEGVSTCRAV 954
Cdd:PRK07279 812 I---NNLDNlfvfvNELGSLFADSSYSWVEAE------DYSETEKYSLEQELLGVGVSKHPLQ----AIAEKSSRPFTPI 878
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 955 QEGADGRRMKV-AGVVTVRQRPGSAKG--VVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQrSLEGVVHL 1031
Cdd:PRK07279 879 SQLVKNSEATIlVQIQSIRVIRTKTKGqqMAFLSVTDTKKKLDVTLFPETYRQYKDELKEGKFYYLKGKIQ-ERDGRLQM 957
|
1050
....*....|
gi 514146994 1032 VAAKLQDRSA 1041
Cdd:PRK07279 958 VLQQIQEASS 967
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
185-827 |
5.95e-90 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 310.24 E-value: 5.95e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 185 IATNDVLYHHPDRRPLQDVLTATRHHTTV--FAAGRLLEKNaerHLKPPHEMVRLFRdyPEAIAATADFVAPITFQLDEL 262
Cdd:PRK05898 138 IAFNSVFYANKNDKIVFNAMLAIKNDLKIdeLKNCQDFDNN---HFLNDNEAQSLFS--PIQLDNLNKVLNELKVEIHDL 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 263 KYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGAD--MIPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGILC- 339
Cdd:PRK05898 213 PINIIKYDKQNSIISSEILKQLCISGLNKRLNANdgQVKKIYVKRLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIg 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 340 QGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSR 419
Cdd:PRK05898 293 PGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDIDTDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAK 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 420 SAIRDVGKALGLSEDVTAALANTVWGLSGGGIDRQHIRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRL 499
Cdd:PRK05898 373 MAIRDVGRILGIDLKVIDKICKNIKPDYEEDLDLAIKKNTILKEMYVLHKELFDLAKKIINAPRQIGTHAAGVVLSNSLL 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 500 DETVPIgPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCIRKAFDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLC 579
Cdd:PRK05898 453 TNIIPI-QLGINDRPLSQYSMEYLERFGLIKMDLLGLKNLTIIDNVLKLIKENQ-----NKKIDLFNINLNDKNVFEDLA 526
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 580 KGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQGdmVHPYLRRRSGQEPCTLPSpspqhgpaNELQQILG 659
Cdd:PRK05898 527 KGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGPQQN--IKTFVERRFKREEFSYWN--------EATKKILE 596
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 660 KTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMAtfRKMGTIHTMEKKM-IDGMVNRGYDRTFAENCFNQIKGFGEYGF 738
Cdd:PRK05898 597 PTHGIIVYQEQVINLVKTIANFDIATADNFRRAIS--KKDEKILIQLKKDfIEGALKNNYKQPLVNQIFEYIFSFADYGF 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 739 PESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGFYAPAQIVRDAREHGVTVLPVDVNFSQWDNILEETpdvHLALR 818
Cdd:PRK05898 675 NHSHSLAYSYISYWMAYLKHYYPLEFLSILLSHTSASKDKLLSYLNEAKEFNISIKKPDINYSSNSFVLDTQ---KQIIR 751
|
....*....
gi 514146994 819 LGFRQIDGF 827
Cdd:PRK05898 752 FGFNTIKGF 760
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
300-873 |
3.06e-85 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 296.99 E-value: 3.06e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 300 PKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGILC-QGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKE 378
Cdd:PRK07135 250 PNVKERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIgPGRGSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRIT 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 379 PPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTV---WGLSGGGIDRQH 455
Cdd:PRK07135 330 MPDIDIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVNAISKLIpnnQSLEEAYDKNKS 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 456 IRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAmDKRSFIEWDKDDIDEVGLMKVDVLS 535
Cdd:PRK07135 410 FFRELISKGDPIYKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTFESK-DNYNQVQYSMEFLEDFGLLKIDLLG 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 536 LGMLTCIRKAFDLIHQHkpqLYGGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAI 615
Cdd:PRK07135 489 LKNLTIIKNIEEKINKE---LLFDHLINFNDLPIIDKKTNNLLSNGKTEGIFQLESPGMKSTIKKVGIDSFEDIVAIISL 565
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 616 VRPGPIQgdMVHPYLRRRsgQEPCTLPSPSPqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMAt 695
Cdd:PRK07135 566 YRPGPIQ--YIPIYAKNK--KNPKNIEKIHP------EYDEIVAPTYGIIIYQEQIMQIAQKVAGFSFAQADLLRRAIS- 634
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 696 fRKMGT-IHTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPM 774
Cdd:PRK07135 635 -KKDETkLDKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYPLVFYSALISNSNG 713
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 775 GFYAPAQIVRDAREHGVTVLPVDVNFSQWDNILEETpDVHLALRLgfrqIDGFSKRDTELLIADRQE--PYRTIEDMHRR 852
Cdd:PRK07135 714 SQENIKKYVKEAKNNGIKVYSPDINFSTENAVFDNG-KIFLPLIM----IKGLGSVAIKKIIDERNKngKYKNFFDFILR 788
|
570 580
....*....|....*....|....*..
gi 514146994 853 LR---LDRRAFTLLADADA---FGSLD 873
Cdd:PRK07135 789 LKfigISKSIIEKLIKANTlrsFGNQD 815
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
11-736 |
1.32e-77 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 273.54 E-value: 1.32e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVrahaQWKDIRKESGFRLFIGCRLSFIDGTPD---------M 81
Cdd:PRK09532 10 SDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAI----ELLKVCRNKGIKPIIGNEMYVINGDIEkqkrrrkyhQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 82 VVYPRDRAAYGQLCRLLT-------EGK---HRAAIKGECHLEWADLLFRARQFQIAVFPPD--EDEPDFAARLTEIAQA 149
Cdd:PRK09532 86 VVLAKNTQGYKNLVKLTTishlqgvQGKgifARPCINKELLEQYHEGLIVTSACLGGEIPQAilSGRPDAARKVAKWYKK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 150 APGSVWLALTMPHQGQDGRRAER-IARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAErHL 228
Cdd:PRK09532 166 LFGDDFYLEIQDHGSQEDRIVNVeIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLRYSGTE-YL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 229 KPPHEMVRLFRDY------PEAIAAT---ADFVAPITFqLDELKYayPDEPIPPGKTAQQHLYDLVWEGAARHYGADM-- 297
Cdd:PRK09532 245 KSAEEMRLLFRDHlpddviAEAIANTlevADKIEPYNI-LGEPRI--PNYPVPSGHTPDTYVEEVAWQGLLERLNCKSrs 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 298 -IPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGI-LCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAE 375
Cdd:PRK09532 322 eVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIpVGPGRGSAAGSLVAYCLKITNIDPVHHGLLFERFLNPE 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 376 RKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVwGLSGGGIDRQH 455
Cdd:PRK09532 402 RKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLI-PVSRGKPTKLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 456 IRQAGLDPD---------NPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPI---GPAAMDKRSFIEwdkdDI 523
Cdd:PRK09532 481 VMISDETPEpefkekydnDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLqknNDGAVITQYFME----DL 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 524 DEVGLMKVDVLSLGMLTCIRKAFDLIHQHKPQ--------------LYGGEKLTLASLPRKDKAVYDMLCKGDSLGVFQV 589
Cdd:PRK09532 557 ESLGLLKMDFLGLRNLTTIQKTADLIKENRGVeidldqlplderkaLKILAKGEAKKLPKDVQKTHKLLERGDLEGIFQL 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 590 ESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQGDMVHPYLRRRSGQEPCTLPSPSpqhgpaneLQQILGKTKGVPLFQE 669
Cdd:PRK09532 637 ESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDYEHQL--------LEPILNETYGVLVYQE 708
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514146994 670 QAMRIAMEAAKFTPEEANQLRRAMATfRKMGTIHTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEY 736
Cdd:PRK09532 709 QIMKMAQDLAGYSLGEADLLRRAMGK-KKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEY 774
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
538-717 |
1.41e-68 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 226.65 E-value: 1.41e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 538 MLTCIRKAFDLIHQHKpqlygGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVR 617
Cdd:pfam17657 1 TLTIIRDALDLIKENR-----GIGIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 618 PGPIQGDMVHPYLRRRSGQEPCTLPSPspqhgpanELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATfR 697
Cdd:pfam17657 76 PGPMQGGNVDDYIKRKHGKEKIEYPHP--------DLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGK-K 146
|
170 180
....*....|....*....|
gi 514146994 698 KMGTIHTMEKKMIDGMVNRG 717
Cdd:pfam17657 147 KPEEMEKLREKFIEGAKENG 166
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
9-206 |
4.49e-23 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 97.27 E-value: 4.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 9 AASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVR-AHAQwkdirKESGFRLFIGCRLSF--IDGTPDMVVYP 85
Cdd:cd07431 5 VHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRfYKAC-----KKAGIKPIIGLELTVegDGEPYPLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 86 RDRAAYGQLCRLLTEGKHRAAIKGECHLEWADLLfrarqfqiavfppdedepdfaarlteiaqAAPGSVWLALTMPhqgq 165
Cdd:cd07431 80 KNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEELA-----------------------------EAASGLLVVLLGP---- 126
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 514146994 166 dgrraeRIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTA 206
Cdd:cd07431 127 ------LLLLLAAEQGLPLVATNDVHYLNPEDAFAADVLTA 161
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
790-879 |
9.44e-21 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 87.53 E-value: 9.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 790 GVTVLPVDVNFSQWDNILEETpdvhlALRLGFRQIDGFSKRDTELLIADRQE-PYRTIEDMHRRLR--LDRRAFTLLADA 866
Cdd:pfam14579 1 GIEVLPPDINRSDWDFTVEGG-----GIRLGLGAIKGLGEAAAERIVEERENgPFKSLEDFARRVDlkLNKRVLEALIKA 75
|
90
....*....|...
gi 514146994 867 DAFGSLDIDRRAA 879
Cdd:pfam14579 76 GAFDSLGGNRRQL 88
|
|
| DnaE_OBF |
cd04485 |
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding ... |
964-1046 |
3.59e-18 |
|
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains two copies of this replicative polymerase, each of which copies a different DNA strand. This group also contains Bacillus subtilis DnaE. Replication in B. subtilis and Staphylococcus aureus requires two different type C polymerases, polC and DnaE, both of which are thought to be included in the DNA polymerase holoenzyme. At the B. subtilis replication fork, polC appears to be involved in leading strand synthesis and DnaE in lagging strand synthesis.
Pssm-ID: 239931 [Multi-domain] Cd Length: 84 Bit Score: 80.25 E-value: 3.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 964 KVAGVVTVRQRPGSAKG--VVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQRSlEGVVHLVAAKLQDRSA 1041
Cdd:cd04485 1 TVAGLVTSVRRRRTKKGkrMAFVTLEDLTGSIEVVVFPETYEKYRDLLKEDALLLVEGKVERR-DGGLRLIAERIEDLED 79
|
....*
gi 514146994 1042 ALIEM 1046
Cdd:cd04485 80 ARERL 84
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
11-248 |
1.03e-13 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 72.90 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAhaqWKDIRKEsGFRLFIGCRLSFIDGTPD-----MVVYP 85
Cdd:cd07433 9 SEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKF---YKAASKA-GIKPIIGADLNVANPDDAdepfrLTLLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 86 RDRAAYGQLCRLLTEG--KHRAAIKGECHLEWAD-------LLFRARQFQIAVFPPDEDEPDFAARLTEIAQAAPGSVWL 156
Cdd:cd07433 85 QNEQGYKNLTELISRAylEGQRNGGPHIKLEWLAeysegliALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPDRFYL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 157 ALTMPHQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTAtrhhttvFAAGRLLEK-------NAERHLK 229
Cdd:cd07433 165 ELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVC-------IAEGRTLDDprrprrySPQQYFK 237
|
250
....*....|....*....
gi 514146994 230 PPHEMVRLFRDYPEAIAAT 248
Cdd:cd07433 238 SAEEMAELFADLPEAIENT 256
|
|
| tRNA_anti-codon |
pfam01336 |
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ... |
964-1038 |
1.48e-11 |
|
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
Pssm-ID: 460164 [Multi-domain] Cd Length: 75 Bit Score: 61.10 E-value: 1.48e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514146994 964 KVAGVVTVRQRPGsaKGVVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQRSLEGVVHLVAAKLQD 1038
Cdd:pfam01336 2 TVAGRVTSIRRSG--GKLLFLTLRDGTGSIQVVVFKEEAEKLAKKLKEGDVVRVTGKVKKRKGGELELVVEEIEL 74
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
11-248 |
4.55e-11 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 64.77 E-value: 4.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQwkdiRKESGFRLFIGC--------RLSFIDGTPD-- 80
Cdd:cd12113 9 TEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKA----AKKAGIKPIIGCevyvapgsRFDKKDKKGDkr 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 81 ---MVVYPRDRAAYGQLCRLL----TEG-------------KHR-------AAIKGEChlewADLLFR---------ARQ 124
Cdd:cd12113 85 yyhLVLLAKNEEGYRNLMKLVslayLEGfyykpridkellaKYSeglialsACLAGEI----PQLLLNgdeeeareaALE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 125 FQiAVFPPDedepDFaarLTEIaqaapgsvwlaltMPHQGQDGRRA-ERIARFAAQAGVPLIATNDVLYHHPDRRPLQDV 203
Cdd:cd12113 161 YR-DIFGKD----NF---YLEL-------------QDHGLPEQKKVnEGLIELAKELGIPLVATNDVHYLNKEDAEAHDV 219
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 514146994 204 L----TATRHHTTvfaaGRLLEKNAERHLKPPHEMVRLFRDYPEAIAAT 248
Cdd:cd12113 220 LlciqTGKTLDDP----NRMRFDTDEFYLKSPEEMRELFPDVPEALENT 264
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
723-1023 |
1.44e-09 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 61.62 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 723 AENCFNQikgfgeygfpeSHAASFAHLVYISAWLKCHHPEVFAAALL--NSqpmgfyAPAQIVRDAREH----GVTVLPV 796
Cdd:PRK07373 34 ASNCFNK-----------SHSTAYAYVTYQTAYLKANYPVEYMAALLtaNS------GNQDKVQKYRENcqkmGIEVEPP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 797 DVNFSQWDNileeTPdVHLALRLGFRQIDGFSKRDTELLIADRQE--PYRTIEDMHRR--LR-LDRRAFTLLADADAFGS 871
Cdd:PRK07373 97 DINRSGKDF----TP-VGEKILFGLSAVRNLGEGAIESILKAREEggEFKSLADFCDRvdLRvVNRRALETLIYCGAFDK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 872 LDIDRRAAL--------WAVRRLPNDET--LPLFRAAAASELAQEPRTKLPEMAASEHVIADY-ETTRLSLK-------- 932
Cdd:PRK07373 172 IEPNRQQLIndlelvidWAQKRAKEKASgqGNLFDLLGGNTSNSSAANNAFEQAPSAPPVADFsLQEKLKLEkellgfyv 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 933 -GHPLQYLREglAAEGVSTCRAVQEGADGRRMKVAGVVTVrqrpGSAKGVV--------FLTIEDETGIANIVIWPKIM- 1002
Cdd:PRK07373 252 sEHPLKSIRR--PARLLSPINLSELEEQKEKTKVSAVVML----NEVKKIVtkkgdpmaFLQLEDLSGQSEAVVFPKSYe 325
|
330 340
....*....|....*....|.
gi 514146994 1003 KVFRREVMSARLIhIEGRIQR 1023
Cdd:PRK07373 326 RISELLQVDARLI-IWGKVDR 345
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
11-70 |
2.83e-08 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 51.50 E-value: 2.83e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQwkdiRKESGFRLFIGC 70
Cdd:smart00481 6 SDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKA----AKKAGIKPIIGL 61
|
|
| PHP_HisPPase |
cd07432 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase ... |
11-75 |
4.33e-05 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213987 [Multi-domain] Cd Length: 129 Bit Score: 44.15 E-value: 4.33e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514146994 11 SNFSFlCGASHPQELVERAHALDLSGIGIADRNTLAGvvraHAQWKDIRKESGFRLFIGCRLSFI 75
Cdd:cd07432 7 SVFSP-DSDMTPEEIVERAIELGLDGIAITDHNTIDG----AEEALKEAYKDGLLVIPGVEVTLV 66
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
11-101 |
1.85e-04 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 43.30 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 11 SNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAhaqWKDIRKEsGFRLFIGCRLSFIDGTP----------- 79
Cdd:pfam02811 6 SEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEF---YKAAKKA-GIKPIIGCEVYVAPGSReetekllakyf 81
|
90 100
....*....|....*....|..
gi 514146994 80 DMVVYPRDRAAYGQLCRLLTEG 101
Cdd:pfam02811 82 DLVLLAVHEVGYKNLIKLSSRA 103
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
172-361 |
2.44e-04 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 45.21 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 172 RIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTAT------RHHTTVfaagrlleknAERHLKPPHEMVRLFR------ 239
Cdd:PRK00448 718 NLIELGKKLNKPVVATGDVHYLDPEDKIYRKILVASqgggnpLNRHPL----------PELHFRTTDEMLDEFAflgeel 787
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514146994 240 ------DYPEAIAATADFVAPITfqlDELkyaYPdePIPPGktAQQHLYDLVWEGAARHYGaDMIPPKVQGLINKELALI 313
Cdd:PRK00448 788 akeivvENTNKIADLIEEIEPIK---DKL---YT--PKIEG--AEEEIRELTYKKAHEIYG-EPLPEIVEKRIEKELNSI 856
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 514146994 314 arLEYEpyFLTVYDI----VTHAREKGILCQGRGSAANSVVCFCLGITGVNP 361
Cdd:PRK00448 857 --IGNG--FAVIYLIsqklVKKSLEDGYLVGSRGSVGSSFVATMIGITEVNP 904
|
|
| PHP_HisPPase_AMP |
cd07438 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) ... |
11-53 |
2.19e-03 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; The PHP domain of this HisPPase family has an unknown function. It has a second domain inserted in the middle that binds adenosine 5-monophosphate (AMP). The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to give histidinol. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to the other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213993 [Multi-domain] Cd Length: 155 Bit Score: 39.68 E-value: 2.19e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 514146994 11 SNFSFlcGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHA 53
Cdd:cd07438 7 STASD--GTLSPEELVELAKEAGLKVLAITDHDTVAGLEEALA 47
|
|
| |
