|
Name |
Accession |
Description |
Interval |
E-value |
| pabB |
TIGR00553 |
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ... |
50-369 |
5.13e-129 |
|
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273133 Cd Length: 328 Bit Score: 380.96 E-value: 5.13e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 50 VVGYLSYEAA--AFFDNALQTHNDRLGNEYLAYFTVHKTCQKKDLPLDYDGITIP-------NQWVSATQKEAYQKAIET 120
Cdd:TIGR00553 1 LVGYLSYEAGpdAAFEPYDAALLADHRRTPLLRFLVFERVEAQPRAAVEAEDDAPadrqaptSDIQSEMTRAEYGEAIDQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 121 IHREMQQGNTYQVNYTLQLTQELNAaDSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTK 200
Cdd:TIGR00553 81 LQDYIRAGDCYQANLTQQFHATWDG-DPLAAFRKLRRRQPAPFSAFLDLGDGAILSLSPELFFSIDGSEIETRPIKGTLP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 201 RGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDIL 280
Cdd:TIGR00553 160 RGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVETYPTVHQLVSTITARLREDLTLSDLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 281 TALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYE 360
Cdd:TIGR00553 240 RALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTLTLDGGRAVYGVGGGIVADSDPEAEYR 319
|
....*....
gi 532373748 361 EVHQKTAFL 369
Cdd:TIGR00553 320 ECLLKAAPL 328
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
13-369 |
1.98e-113 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 343.15 E-value: 1.98e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 13 GQRYLFDEPLVELVAKSLDQVGPVIENVQHYQQLGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYLAYFTVHKTCQKKDL 92
Cdd:PRK07508 11 GRAVLFADPSEIIRARTPDEFAPALAAMERARAAGKWLAGYLSYEAGYLLEPKLAPLMPEGRETPLLCFGVFDAPSPEAP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 93 P--LDYDGITIPNQWVSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAaDSLAIYNKLVVEQAAGYNAYIAHD 170
Cdd:PRK07508 91 ApaRPSENAARLRDPVARWDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGG-DPLALFWALAARQPVGYGALVDLG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 171 DFAVISASPELFFKQEGNRL-TTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDR 249
Cdd:PRK07508 170 GPVILSRSPELFFRVDGEGWiETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 250 LCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNV 329
Cdd:PRK07508 250 LFDIETYPTVHQMVSRVRARLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNV 329
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 532373748 330 PIRTIQL-SHNQATYGVGGGITWQSKWEDEYEEVHQKTAFL 369
Cdd:PRK07508 330 AIRTLSLfPGGRAVFNVGGGIVFDSTAEAEYEECLLKARFA 370
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
112-365 |
5.64e-113 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 337.22 E-value: 5.64e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 112 EAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAA-DSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRL 190
Cdd:pfam00425 1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDiDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 191 TTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDV 270
Cdd:pfam00425 81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 271 KADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGIT 350
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240
|
250
....*....|....*
gi 532373748 351 WQSKWEDEYEEVHQK 365
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
|
|
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
51-365 |
9.57e-106 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 324.36 E-value: 9.57e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 51 VGYLSYEAAAFFDNALQTHNDRLGnEYLAYFTVhktcqkkdlpldYDGITI---PNQWVSATQKEAYQKAIETIHREMQQ 127
Cdd:COG0147 103 VGYFGYDLVRYFERLPDLAPDDLG-LPDAALGL------------YDRLLVfdhLKGTRSNFTREEYLAAVERAKEYIRA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 128 GNTYQVNYTLQLTQELnAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWL 207
Cdd:COG0147 170 GDIFQVVLSQRFSAPF-EGDPLALYRALRRINPSPYMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEE 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 208 DQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCG 287
Cdd:COG0147 249 DAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAG 328
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532373748 288 SITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:COG0147 329 TLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNK 406
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
380-568 |
1.21e-39 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 144.42 E-value: 1.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAATYFA--YPYDEKALQKQLSTYLENKDNAAYRLMIRLSKDG----------KISLSD 447
Cdd:pfam01063 4 ETLRVYNGKIFFLDEHLARLRRSAKLLGipLPFDEEDLRKIIEELLKANGLGVGRLRLTVSRGPggfglptsdpTLAIFV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 448 QPLEPLSADFLTAQLSLQKKDVTASPFTYFKT-SY-------RPHIEQKSYEQLFYNQAGQLLETSIGNLFVQLGRTLYT 519
Cdd:pfam01063 84 SALPPPPESKKKGVISSLVRRNPPSPLPGAKTlNYlenvlarREAKAQGADDALLLDEDGNVTEGSTSNVFLVKGGTLYT 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 532373748 520 PPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:pfam01063 164 PPLESGILPGITRQALLDLAKAlglevEERPITLADLQEADEAFLTNSLRGVTP 217
|
|
| PRK07546 |
PRK07546 |
hypothetical protein; Provisional |
392-571 |
2.98e-35 |
|
hypothetical protein; Provisional
Pssm-ID: 169002 [Multi-domain] Cd Length: 209 Bit Score: 131.64 E-value: 2.98e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 392 LEQHLNRLKEAATYFAYPYDEKALQKQLSTyLENKDNAAYRLMIRLSKDGKISLSDQPLEPLSAD-FLTAQLSLQKKDvT 470
Cdd:PRK07546 21 LDRHLARLERSARALGFPCDPAAVRAKLAE-AVAGAQGPLRLRLTLARDGRLTVETAPLPPLPPDtVWRVAIARTRLD-S 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 471 ASPFTYFKTSYRPHIEQ--------KSYEQLFYNQAGQLLETSIGNLFVQLG-RTLYTPPVVVGILPGLFRQELLATGQA 541
Cdd:PRK07546 99 ADPLLRYKTTRRAAYDAaraelppaEADEVILLNERGEVCEGTITNVFLDRGgGMLTTPPLSCGLLPGVLRAELLDAGRA 178
|
170 180 190
....*....|....*....|....*....|
gi 532373748 542 QEKEVTLADLKEASAIFGGNAVRGLYPLNL 571
Cdd:PRK07546 179 REAVLTVDDLKSARAIWVGNSLRGLIRAEL 208
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
380-568 |
6.22e-19 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 86.59 E-value: 6.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPyDEKALQKQLSTYLE--NKDNAAYRLMI-RLSKDGKISLSDQPLEPLS 454
Cdd:cd01559 12 ETMRALDGRLFLLDAHLARLERSARrlGIPEP-DLPRLRAALESLLAanDIDEGRIRLILsRGPGGRGYAPSVCPGPALY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 455 ADFLTAQLSLQKKDVTA----------SPFTYFKT-SY------RPHIEQKSYEQ-LFYNQAGQLLETSIGNLFVQLGRT 516
Cdd:cd01559 91 VSVIPLPPAWRQDGVRLitcpvrlgeqPLLAGLKHlNYlenvlaKREARDRGADEaLFLDTDGRVIEGTASNLFFVKDGE 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 532373748 517 LYTPPVVVGILPGLFRQELLATGQAQ-----EKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:cd01559 171 LVTPSLDRGGLAGITRQRVIELAAAKgyavdERPLRLEDLLAADEAFLTNSLLGVAP 227
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
375-568 |
2.87e-15 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 76.38 E-value: 2.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 375 IFDlktTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPYDEKALQKQLSTYLE-NKDNAAY-RLMI-RlsKDGKISLSDQP 449
Cdd:COG0115 30 VFE---GIRAYDGRLFRLDEHLARLNRSAKrlGIPIPYTEEELLEAIRELVAaNGLEDGYiRPQVtR--GVGGRGVFAEE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 450 LEP---LSADFLTAQLSLQKKD---VTASPFTYFKTSYRPHI---------------EQKSYEQ-LFYNQAGQLLETSIG 507
Cdd:COG0115 105 YEPtviIIASPLPAYPAEAYEKgvrVITSPYRRAAPGGLGGIktgnylnnvlakqeaKEAGADEaLLLDTDGYVAEGSGS 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532373748 508 NLFVQLGRTLYTPPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:COG0115 185 NVFIVKDGVLVTPPLSGGILPGITRDSVIELARElgipvEERPISLEELYTADEVFLTGTAAEVTP 250
|
|
| pabC_Proteo |
TIGR03461 |
aminodeoxychorismate lyase; Members of this protein family are aminodeoxychorismate lyase (ADC ... |
380-570 |
6.70e-13 |
|
aminodeoxychorismate lyase; Members of this protein family are aminodeoxychorismate lyase (ADC lyase), EC 4.1.3.38, the PabC protein of PABA biosynthesis. PABA (para-aminobenzoate) is a precursor of folate, needed for de novo purine biosynthesis. This enzyme is a pyridoxal-phosphate-binding protein in the class IV aminotransferase family (pfam01063). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 132501 Cd Length: 261 Bit Score: 69.15 E-value: 6.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPyDEKALQKQLSTYLENKDNAAYRLMIRLSKDGK-------------IS 444
Cdd:TIGR03461 25 TTAKVRNGKIELLDLHLERLQDAAArlGIPLP-DWDALREEMAQLAAGYSLGVLKVIISRGSGGRgysppgcsdptriIS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 445 LSDQPLEPlsadfltAQLSLQKKDVTASPFTYFKTSY---------------RPHIEQKSY-EQLFYNQAGQLLETSIGN 508
Cdd:TIGR03461 104 VSPYPAHY-------SAWQQQGIRLGVSPVRLGRNPLlagikhlnrleqvliKAELENSEAdEALVLDTDGNVVECTAAN 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532373748 509 LFVQLGRTLYTPPV----VVGILpglfRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYPLN 570
Cdd:TIGR03461 177 IFWRKGNQVFTPDLsycgVAGVM----RQHVLALLPAlgyeiEEVKAGLEELLSADEVFITNSLMGVVPVN 243
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pabB |
TIGR00553 |
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ... |
50-369 |
5.13e-129 |
|
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273133 Cd Length: 328 Bit Score: 380.96 E-value: 5.13e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 50 VVGYLSYEAA--AFFDNALQTHNDRLGNEYLAYFTVHKTCQKKDLPLDYDGITIP-------NQWVSATQKEAYQKAIET 120
Cdd:TIGR00553 1 LVGYLSYEAGpdAAFEPYDAALLADHRRTPLLRFLVFERVEAQPRAAVEAEDDAPadrqaptSDIQSEMTRAEYGEAIDQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 121 IHREMQQGNTYQVNYTLQLTQELNAaDSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTK 200
Cdd:TIGR00553 81 LQDYIRAGDCYQANLTQQFHATWDG-DPLAAFRKLRRRQPAPFSAFLDLGDGAILSLSPELFFSIDGSEIETRPIKGTLP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 201 RGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDIL 280
Cdd:TIGR00553 160 RGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVETYPTVHQLVSTITARLREDLTLSDLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 281 TALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYE 360
Cdd:TIGR00553 240 RALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTLTLDGGRAVYGVGGGIVADSDPEAEYR 319
|
....*....
gi 532373748 361 EVHQKTAFL 369
Cdd:TIGR00553 320 ECLLKAAPL 328
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
13-369 |
1.98e-113 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 343.15 E-value: 1.98e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 13 GQRYLFDEPLVELVAKSLDQVGPVIENVQHYQQLGYYVVGYLSYEAAAFFDNALQTHNDRLGNEYLAYFTVHKTCQKKDL 92
Cdd:PRK07508 11 GRAVLFADPSEIIRARTPDEFAPALAAMERARAAGKWLAGYLSYEAGYLLEPKLAPLMPEGRETPLLCFGVFDAPSPEAP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 93 P--LDYDGITIPNQWVSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAaDSLAIYNKLVVEQAAGYNAYIAHD 170
Cdd:PRK07508 91 ApaRPSENAARLRDPVARWDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGG-DPLALFWALAARQPVGYGALVDLG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 171 DFAVISASPELFFKQEGNRL-TTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDR 249
Cdd:PRK07508 170 GPVILSRSPELFFRVDGEGWiETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 250 LCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNV 329
Cdd:PRK07508 250 LFDIETYPTVHQMVSRVRARLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNV 329
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 532373748 330 PIRTIQL-SHNQATYGVGGGITWQSKWEDEYEEVHQKTAFL 369
Cdd:PRK07508 330 AIRTLSLfPGGRAVFNVGGGIVFDSTAEAEYEECLLKARFA 370
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
112-365 |
5.64e-113 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 337.22 E-value: 5.64e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 112 EAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAA-DSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRL 190
Cdd:pfam00425 1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDiDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 191 TTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDV 270
Cdd:pfam00425 81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 271 KADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGIT 350
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240
|
250
....*....|....*
gi 532373748 351 WQSKWEDEYEEVHQK 365
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
|
|
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
51-365 |
9.57e-106 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 324.36 E-value: 9.57e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 51 VGYLSYEAAAFFDNALQTHNDRLGnEYLAYFTVhktcqkkdlpldYDGITI---PNQWVSATQKEAYQKAIETIHREMQQ 127
Cdd:COG0147 103 VGYFGYDLVRYFERLPDLAPDDLG-LPDAALGL------------YDRLLVfdhLKGTRSNFTREEYLAAVERAKEYIRA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 128 GNTYQVNYTLQLTQELnAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWL 207
Cdd:COG0147 170 GDIFQVVLSQRFSAPF-EGDPLALYRALRRINPSPYMFYLRFGDFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEE 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 208 DQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCG 287
Cdd:COG0147 249 DAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPELMVVERYSHVMHLVSTVTGRLRPGLDALDALRATFPAG 328
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532373748 288 SITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:COG0147 329 TLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRTAVVKDGRAYVQAGAGIVADSDPEAEYQETLNK 406
|
|
| PabB-clade2 |
TIGR01824 |
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ... |
102-369 |
5.23e-81 |
|
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.
Pssm-ID: 130883 Cd Length: 355 Bit Score: 258.55 E-value: 5.23e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 102 PNQWVSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAA-DSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPE 180
Cdd:TIGR01824 87 PVDLEASIDRAAYETGVRRIKDYIRAGDVFQANLSRRLTAPIAADvDPLQLFLALRAPNPAPYAIYLEEPGVDVASASPE 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 181 LFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVW 260
Cdd:TIGR01824 167 LFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVPELCAVESYSHVH 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 261 QMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQ 340
Cdd:TIGR01824 247 HLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWIDADGNADLNILIRTLEGGGAQ 326
|
250 260
....*....|....*....|....*....
gi 532373748 341 ATYGVGGGITWQSKWEDEYEEVHQKTAFL 369
Cdd:TIGR01824 327 LHFRTGAGIVADSDPAGEWDETEAKARAL 355
|
|
| PRK05877 |
PRK05877 |
aminodeoxychorismate synthase component I; Provisional |
104-372 |
3.44e-58 |
|
aminodeoxychorismate synthase component I; Provisional
Pssm-ID: 235634 [Multi-domain] Cd Length: 405 Bit Score: 199.93 E-value: 3.44e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 104 QWvSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELnAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFF 183
Cdd:PRK05877 135 DW-TPPDRAAHRDGVLACLEAIAAGEVYQACVCTQFTGTV-TGSPLDFFADGVARTAPARAAYLAGDWGAVASLSPELFL 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 184 KQEGNRLTTRPMKGTTKRgvnswldqqeHDW---LQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVW 260
Cdd:PRK05877 213 RRRGSVVTSSPIKGTLPL----------DADpsaLRASAKDVAENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVW 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 261 QMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHN- 339
Cdd:PRK05877 283 HLVSTVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVEFDADg 362
|
250 260 270
....*....|....*....|....*....|...
gi 532373748 340 QATYGVGGGITWQSKWEDEYEEVHQKTAFLYRH 372
Cdd:PRK05877 363 NAVLGVGGGITADSDPDAEWQECLHKAAPIVGL 395
|
|
| PRK05940 |
PRK05940 |
anthranilate synthase component I; |
56-365 |
3.85e-55 |
|
anthranilate synthase component I;
Pssm-ID: 235651 [Multi-domain] Cd Length: 463 Bit Score: 193.41 E-value: 3.85e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 56 YEAAAFfdNALQTHNDRLgneYLAYFTVHK----------TCQKKDLPLDYDGITIPNQWVsaTQKEAYQKAIETIHREM 125
Cdd:PRK05940 131 YEPESF--AILDHQEQIL---WLAASDPSQldrleqqleqPTPEPDLPLDLRTPPSSLIFY--TTQQEYEAAVRQAKKYI 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 126 QQGNTYQVNYTL--QLTQElnaADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGV 203
Cdd:PRK05940 204 QAGDIFQANLSLrfQTTTS---ADSWQIYRRLQQINPSPFASYWRTPWGDVVSCSPERLVQLQGNQAQTRPIAGTRPRGK 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 204 NSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTAL 283
Cdd:PRK05940 281 TPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSVEVDELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRAL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 284 FPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQA----TYG-VGGGITWQSKWEDE 358
Cdd:PRK05940 361 FPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNLDLNILIRTLLYTPLSRglstIWGqVGAGIVADSDPEKE 440
|
....*..
gi 532373748 359 YEEVHQK 365
Cdd:PRK05940 441 WLESLQK 447
|
|
| PLN02889 |
PLN02889 |
oxo-acid-lyase/anthranilate synthase |
105-366 |
7.43e-55 |
|
oxo-acid-lyase/anthranilate synthase
Pssm-ID: 215481 [Multi-domain] Cd Length: 918 Bit Score: 200.07 E-value: 7.43e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 105 WVSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAADSLAIYNKLVVEQAAGYNAYI--AHDDFAVISASPELF 182
Cdd:PLN02889 637 FLADKSREQYIKDVQKCLKYIKDGESYELCLTTQMRKRIGEIDSLGLYLHLREKNPAPYAAWLnfSNENLCICSSSPERF 716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 183 FKQEGN-RLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQ 261
Cdd:PLN02889 717 LKLDRNgMLEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHT 796
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 262 MTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQA 341
Cdd:PLN02889 797 MVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIYSGSIGFFSYNQTFDLNIVIRTVVIHEGEA 876
|
250 260
....*....|....*....|....*
gi 532373748 342 TYGVGGGITWQSKWEDEYEEVHQKT 366
Cdd:PLN02889 877 SIGAGGAIVALSNPEDEYEEMILKT 901
|
|
| PRK09070 |
PRK09070 |
aminodeoxychorismate synthase component I; |
112-371 |
5.57e-54 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236371 [Multi-domain] Cd Length: 447 Bit Score: 189.91 E-value: 5.57e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 112 EAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAA-DSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRL 190
Cdd:PRK09070 183 ERFTDGVERVLDYIRAGDVFQVNLSRAWQAQFANAvDPAALYARLRAANPAPFSGLFVAAGRAIVSSSPERLVSVQGGVV 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 191 TTRPMKGTTKRGVNS---WLDQQehdwLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIV 267
Cdd:PRK09070 263 QTRPIAGTRPRFAGDddaALIRE----LVGHPKERAEHVMLIDLERNDLGRICAPGSVEVDELMTVESYAHVHHIVSNVR 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 268 GDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGG 347
Cdd:PRK09070 339 GRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGDMDLNILIRTAEVQGNQVRFRTGA 418
|
250 260
....*....|....*....|....
gi 532373748 348 GITWQSKWEDEYEEVHQKTAFLYR 371
Cdd:PRK09070 419 GIVVDSDPERELDETRAKARGLLR 442
|
|
| pabB |
PRK15465 |
aminodeoxychorismate synthase component 1; |
58-365 |
1.52e-48 |
|
aminodeoxychorismate synthase component 1;
Pssm-ID: 185362 [Multi-domain] Cd Length: 453 Bit Score: 175.11 E-value: 1.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 58 AAAFFDNALQTHNDRLGNEYLAYFTVHKTCQ--KKDLPLDYDGITIPNQWVSATQKEAYQKAIETIHREMQQGNTYQVNy 135
Cdd:PRK15465 135 AVGIYDWALIVDHQRQTVSLLSHNDVNARRAwlESQQFSPQEDFTLTSDWQSNMTREQYGEKFRQVQEYLHSGDCYQVN- 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 136 tlqLTQELNAA---DSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEH 212
Cdd:PRK15465 214 ---LAQRFHATysgDEWQAFLQLNQANRAPFSAFLRLEQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQA 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 213 DWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCGSITGA 292
Cdd:PRK15465 291 EKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGA 370
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532373748 293 PKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:PRK15465 371 PKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDK 443
|
|
| PRK07093 |
PRK07093 |
para-aminobenzoate synthase component I; Validated |
81-365 |
8.11e-48 |
|
para-aminobenzoate synthase component I; Validated
Pssm-ID: 235932 [Multi-domain] Cd Length: 323 Bit Score: 169.66 E-value: 8.11e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 81 FTVHKTCQKKDLPLDYDGITIPnqwvsatqKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAadSLA-IYNKlvveQ 159
Cdd:PRK07093 51 KTNVPSQVRPHKPFELQKEPIS--------FEEYQQGFELVQEEIQAGNSYLLNLTYPTPIETNL--SLEeIFQA----S 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 160 AAGYNAYIaHDDFAVISasPELFFKQEGNRLTTRPMKGTtkrgVNSWLDQQEHdWLQADGKNRSENMMIVDLLRNDMGKI 239
Cdd:PRK07093 117 KAKYKLLF-KDQFVCFS--PEPFVRIEDNKISTYPMKGT----IDASLPNAEE-KLLNDEKEFAEHATIVDLLRNDLSMV 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 240 CQtgSVCVDRLCEVERYST----VWQMTSTIVGDVKADCD--LIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYC 313
Cdd:PRK07093 189 AK--NVRVTRFRYIDKIKTnkgeILQTSSEISGTLPENWQenIGDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYT 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 532373748 314 GSIGIClpDGRRFFN-VPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:PRK07093 267 GVFGYF--DGESLDSaVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
|
|
| PRK13571 |
PRK13571 |
anthranilate synthase component I; Provisional |
106-367 |
3.62e-45 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184152 [Multi-domain] Cd Length: 506 Bit Score: 167.12 E-value: 3.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 106 VSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQElNAADSLAIYNKLVVEQAAGYnAYIAH-------DDFAVISAS 178
Cdd:PRK13571 224 RAQRTVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMD-TTADPLDVYRVLRVTNPSPY-MYLLRvpnsdggTDFSIVGSS 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 179 PELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYST 258
Cdd:PRK13571 302 PEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHIERYSH 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 259 VWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSH 338
Cdd:PRK13571 382 VMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVVGYLDFAGDADTAIAIRTALMRD 461
|
250 260
....*....|....*....|....*....
gi 532373748 339 NQATYGVGGGITWQSKWEDEYEEVHQKTA 367
Cdd:PRK13571 462 GTAYVQAGGGVVADSDPDYEDNEARNKAA 490
|
|
| PRK13574 |
PRK13574 |
anthranilate synthase component I; Provisional |
3-365 |
3.18e-44 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184155 [Multi-domain] Cd Length: 420 Bit Score: 162.68 E-value: 3.18e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 3 RKTIIDFKELGQRYLFDEPlVELVAKSLDQVGpvIENVQHYQQLGyyVVGYLSYEAAAFFDNALQTHNDRLGNEYLAYFT 82
Cdd:PRK13574 40 RYSVIAWGTNGYLKIHDDP-VNILNSYLKDLK--LVDIPGLFKGG--MIGYISYDAVRFWEKIRDLKPAAEDWPYAEFFI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 83 -----VHKTCQKK-----DLPLDYDGITIPNQWVS----ATQKEAYQKAIETIHREMQQGNTYQV------NYTLQltqe 142
Cdd:PRK13574 115 pdniiIYDHNEGKvyvngDLSSVGGCGDMGEFKISfydeSLNKNNYEKIVSESLEYIRSGYIFQVvlsrfyRYLFS---- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 143 lnaADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNR 222
Cdd:PRK13574 191 ---GDPLRIYYNLRRINPSPYMFYLKFDERYLIGSSPELLFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 223 SENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIIT 302
Cdd:PRK13574 268 AEHLMLVDLARNDLGKVCVPGTVRVPELMYVEKYSHVQHIVSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIE 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532373748 303 SLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:PRK13574 348 TLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKDLLRIQAGAGIVYDSNPESEYFETEHK 410
|
|
| PLN02445 |
PLN02445 |
anthranilate synthase component I |
107-385 |
4.42e-41 |
|
anthranilate synthase component I
Pssm-ID: 215244 [Multi-domain] Cd Length: 523 Bit Score: 155.99 E-value: 4.42e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 107 SATQKEAYQKAIETIHREMQQGNTYQVNYTlQLTQELNAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPELFFKQE 186
Cdd:PLN02445 231 SNMTSEEYKNAVLQAKEHILAGDIFQIVLS-QRFERRTFADPFEVYRALRIVNPSPYMIYLQARGCILVASSPEILTRVK 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 187 GNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTI 266
Cdd:PLN02445 310 KNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVDLGRNDVGKVSKAGSVKVEKLMNIERYSHVMHISSTV 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 267 VGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIG----------------ICLPDGRRFFNV- 329
Cdd:PLN02445 390 TGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEVTRRGPYSGGFGgvsftgdmdialalrtMVFPTAARYDTMy 469
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532373748 330 -----PIRTIQLSHNQAtygvGGGITWQSKWEDEYEEVHQKTAFLYRhkqIFDLKTTAKVK 385
Cdd:PLN02445 470 sykdtNSRREWVAHLQA----GAGIVADSDPEDEYRECVNKAAGLAR---AIDLAESAFVK 523
|
|
| PRK13572 |
PRK13572 |
anthranilate synthase component I; Provisional |
111-367 |
1.45e-40 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 237432 [Multi-domain] Cd Length: 435 Bit Score: 152.97 E-value: 1.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 111 KEAYQKAIETIHREMQQGNTYQV----NYTLQltqelNAADSLAIYNKLVVEQAAGYnAYIAHDDFAVISASPELFFKQE 186
Cdd:PRK13572 172 REEFVEMVEKAKEYIYSGDVFQVvlsrEYRLK-----TDLSPFQLYRNLREINPSPY-MFLLEFDKDVVGASPETMASVE 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 187 GNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQMTSTI 266
Cdd:PRK13572 246 NNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERFFDVVKYSHVQHIESEV 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 267 VGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLShNQATYGVG 346
Cdd:PRK13572 326 VGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFSNSGNADLAIAIRMAEID-KVCRVRAG 404
|
250 260
....*....|....*....|.
gi 532373748 347 GGITWQSKWEDEYEEVHQKTA 367
Cdd:PRK13572 405 AGIVADSVPEKEFYETERKMA 425
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
380-568 |
1.21e-39 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 144.42 E-value: 1.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAATYFA--YPYDEKALQKQLSTYLENKDNAAYRLMIRLSKDG----------KISLSD 447
Cdd:pfam01063 4 ETLRVYNGKIFFLDEHLARLRRSAKLLGipLPFDEEDLRKIIEELLKANGLGVGRLRLTVSRGPggfglptsdpTLAIFV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 448 QPLEPLSADFLTAQLSLQKKDVTASPFTYFKT-SY-------RPHIEQKSYEQLFYNQAGQLLETSIGNLFVQLGRTLYT 519
Cdd:pfam01063 84 SALPPPPESKKKGVISSLVRRNPPSPLPGAKTlNYlenvlarREAKAQGADDALLLDEDGNVTEGSTSNVFLVKGGTLYT 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 532373748 520 PPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:pfam01063 164 PPLESGILPGITRQALLDLAKAlglevEERPITLADLQEADEAFLTNSLRGVTP 217
|
|
| PabB-fungal |
TIGR01823 |
aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a ... |
86-365 |
6.81e-38 |
|
aminodeoxychorismate synthase, fungal clade; This model represents the fungal clade of a para-aminobenzoate synthesis enzyme, aminodeoxychorismate synthase, which acts on chorismate in a pathway that yields PABA, a precursor of folate.
Pssm-ID: 273821 [Multi-domain] Cd Length: 742 Bit Score: 149.29 E-value: 6.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 86 TCQKKDLPLD----YDGITIPNQWVSATQKEAYQKAIETIHREMQQGNTYQVNYTLQLTQELNAADSLA--IYNKLVVEQ 159
Cdd:TIGR01823 441 FVRKKNIKQSlswpFYLPEEIDFVITFPDKEDYAKAFKACQDYLHAGDSYEMCLTTQTKVVPPAVISPDweIYQRLRQRN 520
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 160 AAGYNAYIAHDDFAVISASPELFFK-QEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQAdgKNRSENMMIVDLLRNDMGK 238
Cdd:TIGR01823 521 PAPFSGFFRLKHIIFLSTSPEKFLEvGMDTHAKLRPIKGTVKKGPQMNLEKARRILKTP--KEMGENLMILDLIRNDLYE 598
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 239 ICQTGSVCVDRLCEVERYSTVWQMTSTIVGDV------KADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIY 312
Cdd:TIGR01823 599 LVPKNDVHVEELMSVEEHATVYQLVSVVKAHGltsaskKTRYSGIDVLKHSLPPGSMTGAPKKRSVQLLQDVEGGARGIY 678
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 532373748 313 CGSIGICLPDGRRFFNVPIRTIqLSHNQATY---GVGGGITWQSKWEDEYEEVHQK 365
Cdd:TIGR01823 679 SGVTGYWDVNGNGDFSVNIRCA-FSYNGGTSwriGAGGAVTVLSTPEGELEEMYNK 733
|
|
| PRK07546 |
PRK07546 |
hypothetical protein; Provisional |
392-571 |
2.98e-35 |
|
hypothetical protein; Provisional
Pssm-ID: 169002 [Multi-domain] Cd Length: 209 Bit Score: 131.64 E-value: 2.98e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 392 LEQHLNRLKEAATYFAYPYDEKALQKQLSTyLENKDNAAYRLMIRLSKDGKISLSDQPLEPLSAD-FLTAQLSLQKKDvT 470
Cdd:PRK07546 21 LDRHLARLERSARALGFPCDPAAVRAKLAE-AVAGAQGPLRLRLTLARDGRLTVETAPLPPLPPDtVWRVAIARTRLD-S 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 471 ASPFTYFKTSYRPHIEQ--------KSYEQLFYNQAGQLLETSIGNLFVQLG-RTLYTPPVVVGILPGLFRQELLATGQA 541
Cdd:PRK07546 99 ADPLLRYKTTRRAAYDAaraelppaEADEVILLNERGEVCEGTITNVFLDRGgGMLTTPPLSCGLLPGVLRAELLDAGRA 178
|
170 180 190
....*....|....*....|....*....|
gi 532373748 542 QEKEVTLADLKEASAIFGGNAVRGLYPLNL 571
Cdd:PRK07546 179 REAVLTVDDLKSARAIWVGNSLRGLIRAEL 208
|
|
| PRK06404 |
PRK06404 |
anthranilate synthase component I; Reviewed |
163-365 |
4.45e-33 |
|
anthranilate synthase component I; Reviewed
Pssm-ID: 102361 [Multi-domain] Cd Length: 351 Bit Score: 129.99 E-value: 4.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 163 YNAYIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSwldqqehDWLQADGKNRSENMMIVDLLRNDMGKICQT 242
Cdd:PRK06404 153 YVFYYRFGKYRVVGSSPENVFTVNGNIINVDPIAGTYDDKILS-------NELLNSEKDKLEHRMLLDLARNDLSKFADI 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 243 GSVCVDRLCEVERYSTVWQMTSTIVGDVkADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGIcLPD 322
Cdd:PRK06404 226 GTLNVDKVMKIEEFSSVKHLVSQVTAKF-SNASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGI-ISK 303
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 532373748 323 GRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:PRK06404 304 GYTDMALVIRTAYSHGNGFRVRAGAGIVKDSDPEDEVNEIYSK 346
|
|
| PRK13567 |
PRK13567 |
anthranilate synthase component I; Provisional |
92-365 |
1.20e-32 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184148 [Multi-domain] Cd Length: 468 Bit Score: 131.03 E-value: 1.20e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 92 LPLDYDGITIPNQWVSATQKEAYQKAIETIHREMQQGNTYQV------NYTLQLTQELNAAdSLAIYNKLVVEQAAGYNA 165
Cdd:PRK13567 181 FMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVvpsriyKYAHHASQHLNQL-SFQLYQNLKRQNPSPYMY 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 166 YIAHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSV 245
Cdd:PRK13567 260 YLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTS 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 246 CVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRR 325
Cdd:PRK13567 340 KITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNL 419
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 532373748 326 FFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:PRK13567 420 DFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLK 459
|
|
| PRK13564 |
PRK13564 |
anthranilate synthase component 1; |
112-318 |
1.31e-26 |
|
anthranilate synthase component 1;
Pssm-ID: 237428 [Multi-domain] Cd Length: 520 Bit Score: 113.78 E-value: 1.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 112 EAYQKAIETIHREMQQGNTYQVnyTLQLTQELNAADSLAIYNKLVVEQAAGYNAYIAHDDFAVISASPE--LFFKQEGNR 189
Cdd:PRK13564 243 EEFCAVVRKLKEHIRAGDIFQV--VPSRRFSLPCPSPLAAYRVLKKSNPSPYMFYMQDEDFTLFGASPEsaLKYDASSRQ 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 190 LTTRPMKGTTKRG------VNSWLDQQ-EHDwLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYSTVWQM 262
Cdd:PRK13564 321 VEIYPIAGTRPRGrradgsIDRDLDSRiELE-LRTDHKELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRYSHVMHL 399
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 532373748 263 TSTIVGDVKADCdliDILTALFPC---GSITGAPKVSTMAIITSLEPKPRGIYCGSIGI 318
Cdd:PRK13564 400 VSRVVGELRHDL---DALHAYRACmnmGTLTGAPKVRAMQLIREVEGQRRGSYGGAVGY 455
|
|
| PRK15016 |
PRK15016 |
isochorismate synthase EntC; Provisional |
145-361 |
1.10e-19 |
|
isochorismate synthase EntC; Provisional
Pssm-ID: 184977 [Multi-domain] Cd Length: 391 Bit Score: 91.47 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 145 AADSLAIYNKLVVEQAAGYNAYIAHDDFAVI-SASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRS 223
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLlGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 224 ENMMIVDLLRndmgkicqtgSVCVDRLCEVERYS--------TVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKV 295
Cdd:PRK15016 241 EHELVTQAMK----------EVLRERSSELHVPSspqlittpTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQ 310
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532373748 296 STMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEE 361
Cdd:PRK15016 311 AAKQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRE 376
|
|
| PRK06772 |
PRK06772 |
salicylate synthase; |
178-367 |
4.03e-19 |
|
salicylate synthase;
Pssm-ID: 102546 [Multi-domain] Cd Length: 434 Bit Score: 90.18 E-value: 4.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 178 SPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERYS 257
Cdd:PRK06772 238 SPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQRG 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 258 TVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIgICLPDGRRFFNVPIRTIQLS 337
Cdd:PRK06772 318 SVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAI-LLLDDTRFDAALVLRSVFQD 396
|
170 180 190
....*....|....*....|....*....|
gi 532373748 338 HNQATYGVGGGITWQSKWEDEYEEVHQKTA 367
Cdd:PRK06772 397 SQRCWIQAGAGIIAQSTPERELTETREKLA 426
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
380-568 |
6.22e-19 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 86.59 E-value: 6.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPyDEKALQKQLSTYLE--NKDNAAYRLMI-RLSKDGKISLSDQPLEPLS 454
Cdd:cd01559 12 ETMRALDGRLFLLDAHLARLERSARrlGIPEP-DLPRLRAALESLLAanDIDEGRIRLILsRGPGGRGYAPSVCPGPALY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 455 ADFLTAQLSLQKKDVTA----------SPFTYFKT-SY------RPHIEQKSYEQ-LFYNQAGQLLETSIGNLFVQLGRT 516
Cdd:cd01559 91 VSVIPLPPAWRQDGVRLitcpvrlgeqPLLAGLKHlNYlenvlaKREARDRGADEaLFLDTDGRVIEGTASNLFFVKDGE 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 532373748 517 LYTPPVVVGILPGLFRQELLATGQAQ-----EKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:cd01559 171 LVTPSLDRGGLAGITRQRVIELAAAKgyavdERPLRLEDLLAADEAFLTNSLLGVAP 227
|
|
| PRK13566 |
PRK13566 |
anthranilate synthase component I; |
175-369 |
1.16e-17 |
|
anthranilate synthase component I;
Pssm-ID: 237429 [Multi-domain] Cd Length: 720 Bit Score: 86.89 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 175 ISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVE 254
Cdd:PRK13566 307 VGASPEMFVRVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIE 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 255 RYSTVWQMTSTIVGDVKADCDLID-ILT---ALfpcgSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRrfFN-- 328
Cdd:PRK13566 387 MYSRLIHTVDHVEGRLRPGFDALDaFLThawAV----TVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGD--MNtg 460
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 532373748 329 VPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQK-TAFL 369
Cdd:PRK13566 461 LTLRTIRIKDGVAEVRVGATLLFDSDPEAEEAETELKaSALL 502
|
|
| PRK07912 |
PRK07912 |
salicylate synthase; |
178-369 |
1.24e-15 |
|
salicylate synthase;
Pssm-ID: 169151 [Multi-domain] Cd Length: 449 Bit Score: 79.45 E-value: 1.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 178 SPELFFKQEGNRL-TTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSVCVDRLCEVERY 256
Cdd:PRK07912 249 SPELVTAVRADGVvITEPLAGTRAFGRGAAIDRLARDDLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRER 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 257 STVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQL 336
Cdd:PRK07912 329 GSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAYQ 408
|
170 180 190
....*....|....*....|....*....|...
gi 532373748 337 SHNQATYGVGGGITWQSKWEDEYEEVHQKTAFL 369
Cdd:PRK07912 409 VGGRTWLRAGAGIIEESEPEREFEETCEKLSTL 441
|
|
| PRK15012 |
PRK15012 |
menaquinone-specific isochorismate synthase; Provisional |
137-369 |
2.04e-15 |
|
menaquinone-specific isochorismate synthase; Provisional
Pssm-ID: 184974 [Multi-domain] Cd Length: 431 Bit Score: 78.73 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 137 LQLTQELNAADSLAIYNKLVVEqaaGYNAYIAHD-DFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWL 215
Cdd:PRK15012 199 LHFASPVNAAAMMAASRRLNLN---CYHFYMAFDaENAFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 216 QADGKNRSENMMIVDllrndmgKICQTGSVCVDRL----CEVERYSTVWQMTSTIVGDVKADCDLIdILTALFPCGSITG 291
Cdd:PRK15012 276 MADDKNQRENMLVVE-------DICQRLQADTQTLdvlpPQVLRLRKVQHLRRCIWTSLNKADDVI-CLHQLQPTAAVAG 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 532373748 292 APKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFnVPIRTIQLSHNQATYGVGGGITWQSKWEDEYEEVHQKTAFL 369
Cdd:PRK15012 348 LPRDLARQFIARHEPFTREWYAGSAGYLSLQQSEFC-VSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGL 424
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
375-568 |
2.87e-15 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 76.38 E-value: 2.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 375 IFDlktTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPYDEKALQKQLSTYLE-NKDNAAY-RLMI-RlsKDGKISLSDQP 449
Cdd:COG0115 30 VFE---GIRAYDGRLFRLDEHLARLNRSAKrlGIPIPYTEEELLEAIRELVAaNGLEDGYiRPQVtR--GVGGRGVFAEE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 450 LEP---LSADFLTAQLSLQKKD---VTASPFTYFKTSYRPHI---------------EQKSYEQ-LFYNQAGQLLETSIG 507
Cdd:COG0115 105 YEPtviIIASPLPAYPAEAYEKgvrVITSPYRRAAPGGLGGIktgnylnnvlakqeaKEAGADEaLLLDTDGYVAEGSGS 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 532373748 508 NLFVQLGRTLYTPPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:COG0115 185 NVFIVKDGVLVTPPLSGGILPGITRDSVIELARElgipvEERPISLEELYTADEVFLTGTAAEVTP 250
|
|
| PRK07054 |
PRK07054 |
isochorismate synthase; |
106-361 |
3.49e-14 |
|
isochorismate synthase;
Pssm-ID: 235920 [Multi-domain] Cd Length: 475 Bit Score: 75.19 E-value: 3.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 106 VSATQKEAYQ-KAIETIHReMQQGNTYQVnyTLQLTQELNAADSLAIY---NKLVVEQAAGYNAYIAHDDFAVISASPEL 181
Cdd:PRK07054 189 ASALQAREWQhEVRRAVDA-IRGGAFGKV--VLARDVLQQYARPVAIGpllRRLRLRDPHAHLFAFRRGNACFLGATPER 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 182 FFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTGSV-CVDRLcevERYSTVW 260
Cdd:PRK07054 266 LVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSRALDIpDQPSL---HRLPRLQ 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 261 QMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRTIQLSHNQ 340
Cdd:PRK07054 343 HLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGDFAVALRSALITGGA 422
|
250 260
....*....|....*....|.
gi 532373748 341 ATYGVGGGITWQSKWEDEYEE 361
Cdd:PRK07054 423 CRLFAGCGIVADSEPASEYRE 443
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
367-568 |
4.42e-14 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 72.25 E-value: 4.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 367 AFLYRHkQIFDlktTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPYDEKALQKQLSTYL--ENKDNAAYRLMIRLSKDGK 442
Cdd:cd00449 3 GLHYGD-GVFE---GLRAGKGRLFRLDEHLDRLNRSAKrlGLPIPYDREELREALKELVaaNNGASLYIRPLLTRGVGGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 443 ISLSDQPLEPLSADFLT---AQLSLQKKDVTASPFTYFKTSYRP------------------HIEQKSYEQ-LFYNQAGQ 500
Cdd:cd00449 79 GVAPPPSPEPTFVVFASpvgAYAKGGEKGVRLITSPDRRRAAPGgtgdaktggnlnsvlakqEAAEAGADEaLLLDDNGY 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532373748 501 LLETSIGNLFVQLGRTLYTPPVVVGILPGLFRQELLATGQAQ-----EKEVTLADLKEASAIFGGNAVRGLYP 568
Cdd:cd00449 159 VTEGSASNVFIVKDGELVTPPLDGGILPGITRDSVIELAKELgikveERPISLDELYAADEVFLTGTAAEVTP 231
|
|
| PRK06923 |
PRK06923 |
isochorismate synthase DhbC; Validated |
112-365 |
1.94e-13 |
|
isochorismate synthase DhbC; Validated
Pssm-ID: 235886 [Multi-domain] Cd Length: 399 Bit Score: 72.46 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 112 EAYQKAIETIHREMQQGNTYQVnyTLQLTQELNAADSLAIyNKLVVEQAA----GYNayiahddFAV------------- 174
Cdd:PRK06923 122 EVYMNGVKQGIAKIQDGDLKKI--VLSRSLDVKSSEKIDK-QKLLRELAEhnkhGYT-------FAVnlpkdenensktl 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 175 ISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQEHDWLQADGKNRSENMMIVDLLRNDMGKICQTgsVCVDRLCEVE 254
Cdd:PRK06923 192 IGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAALRPYCHT--LHVPEKPSVI 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 255 RYSTVWQMTSTIVGDVK-ADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYCGSIGICLPDGRRFFNVPIRT 333
Cdd:PRK06923 270 HTEAMWHLSTEVKGELKdPNTSSLELAIALHPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWIVTIRC 349
|
250 260 270
....*....|....*....|....*....|..
gi 532373748 334 IQLSHNQATYGVGGGITWQSKWEDEYEEVHQK 365
Cdd:PRK06923 350 AEVEENTLRLYAGAGVVAESKPEDELAETSAK 381
|
|
| pabC_Proteo |
TIGR03461 |
aminodeoxychorismate lyase; Members of this protein family are aminodeoxychorismate lyase (ADC ... |
380-570 |
6.70e-13 |
|
aminodeoxychorismate lyase; Members of this protein family are aminodeoxychorismate lyase (ADC lyase), EC 4.1.3.38, the PabC protein of PABA biosynthesis. PABA (para-aminobenzoate) is a precursor of folate, needed for de novo purine biosynthesis. This enzyme is a pyridoxal-phosphate-binding protein in the class IV aminotransferase family (pfam01063). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 132501 Cd Length: 261 Bit Score: 69.15 E-value: 6.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAAT--YFAYPyDEKALQKQLSTYLENKDNAAYRLMIRLSKDGK-------------IS 444
Cdd:TIGR03461 25 TTAKVRNGKIELLDLHLERLQDAAArlGIPLP-DWDALREEMAQLAAGYSLGVLKVIISRGSGGRgysppgcsdptriIS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 445 LSDQPLEPlsadfltAQLSLQKKDVTASPFTYFKTSY---------------RPHIEQKSY-EQLFYNQAGQLLETSIGN 508
Cdd:TIGR03461 104 VSPYPAHY-------SAWQQQGIRLGVSPVRLGRNPLlagikhlnrleqvliKAELENSEAdEALVLDTDGNVVECTAAN 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 532373748 509 LFVQLGRTLYTPPV----VVGILpglfRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYPLN 570
Cdd:TIGR03461 177 IFWRKGNQVFTPDLsycgVAGVM----RQHVLALLPAlgyeiEEVKAGLEELLSADEVFITNSLMGVVPVN 243
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
384-558 |
1.04e-09 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 59.53 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 384 VKHKKIAFLEQHLNRLKEAATY--FAYPYDEKALQ---KQLSTYLENKDNAAYrlmIRLS--KDGKISLSDQPLEPLSAd 456
Cdd:cd01558 33 VYNGKPFALDEHLDRLYRSAKElrIDIPYTREELKeliRELVAKNEGGEGDVY---IQVTrgVGPRGHDFPKCVKPTVV- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 457 FLTAQLSLQKKDVTASPFT------------YFKT-SYRPHI-------EQKSYEQLFYNQAGQLLETSIGNLFVQLGRT 516
Cdd:cd01558 109 IITQPLPLPPAELLEKGVRvitvpdirwlrcDIKSlNLLNNVlakqeakEAGADEAILLDADGLVTEGSSSNVFIVKNGV 188
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 532373748 517 LYTPPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIF 558
Cdd:cd01558 189 LVTPPLDNGILPGITRATVIELAKElgipvEERPFSLEELYTADEVF 235
|
|
| PRK06092 |
PRK06092 |
4-amino-4-deoxychorismate lyase; Reviewed |
380-570 |
1.40e-09 |
|
4-amino-4-deoxychorismate lyase; Reviewed
Pssm-ID: 235696 Cd Length: 268 Bit Score: 59.08 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEAATYFAYPY-DEKALQKQLSTYLENKDNAAYRLMIRLSKDGK-------------ISL 445
Cdd:PRK06092 27 TTARVRDGQVSLLSRHLQRLQDACERLAIPLdDWAQLEQEMKQLAAELENGVLKVIISRGSGGRgyspagcaaptriLSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 446 SDQPLEPLS------ADFLTAQ-LSLQ------K-----KDVTAspftyfktsyRPHIEQKSY-EQLFYNQAGQLLETSI 506
Cdd:PRK06092 107 SPYPAHYSRwreqgiTLALCPTrLGRNpllagiKhlnrlEQVLI----------RAELEQTEAdEALVLDSEGWVIECCA 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532373748 507 GNLFVQLGRTLYTPPV----VVGILpglfRQELLATGQA-----QEKEVTLADLKEASAIFGGNAVRGLYPLN 570
Cdd:PRK06092 177 ANLFWRKGGVVYTPDLdqcgVAGVM----RQFILELLAQsgypvVEVDASLEELLQADEVFICNSLMPVWPVR 245
|
|
| PLN02786 |
PLN02786 |
isochorismate synthase |
159-367 |
1.56e-08 |
|
isochorismate synthase
Pssm-ID: 178383 [Multi-domain] Cd Length: 533 Bit Score: 57.49 E-value: 1.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 159 QAAGYNAYI----AHDDFAVISASPELFFKQEGNRLTTRPMKGTTKRGVNSWLDQQ-EHDWLQADgKNRSENMMIVDLLR 233
Cdd:PLN02786 307 QVEGQNAYQfclqPPDAPAFIGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQiELDLLTSP-KDDLEFSIVRENIR 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 234 NDMGKICQTgsVCVDRLCEVERYSTVWQMTSTIVGDVKADCDLIDILTALFPCGSITGAPKVSTMAIITSLEPKPRGIYC 313
Cdd:PLN02786 386 EKLEAICDR--VVVEPHKAIRKLARVQHLYAQLAGRLRSEDDEFDILAALHPTPAVCGHPTEEARLLIAETESFDRGMYA 463
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 532373748 314 GSIGIcLPDGRRFFNVPIRT--IQLSHNQATYGvGGGITWQSKWEDEYEEVHQKTA 367
Cdd:PLN02786 464 GPVGW-FGGGESEFAVGIRSalVEKGLGALIYA-GTGIVEGSNPSSEWNELELKIS 517
|
|
| PRK07650 |
PRK07650 |
4-amino-4-deoxychorismate lyase; Provisional |
491-570 |
1.12e-06 |
|
4-amino-4-deoxychorismate lyase; Provisional
Pssm-ID: 181067 Cd Length: 283 Bit Score: 50.35 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 491 EQLFYNQAGQLLETSIGNLFVQLGRTLYTPPVVVGILPGLFRQELLATGQAQEKEV-----TLADLKEASAIFGGNAVRG 565
Cdd:PRK07650 165 EGIFLTEEGYVAEGIVSNLFWVKGDIVYTPSLETGILNGITRAFVIKVLEELGIEVkegfyTKEELLSADEVFVTNSIQE 244
|
....*
gi 532373748 566 LYPLN 570
Cdd:PRK07650 245 IVPLT 249
|
|
| PRK09266 |
PRK09266 |
hypothetical protein; Provisional |
380-569 |
3.02e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 236438 Cd Length: 266 Bit Score: 46.13 E-value: 3.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 380 TTAKVKHKKIAFLEQHLNRLKEA-ATYFAYPYDEKALQKQLSTYLENK---------------------DNAAYRLMIRL 437
Cdd:PRK09266 29 TSMQVRDGRVRGLDLHLQRLRRAsRELFGAALDDDRVRAQLRAALAAGpadasvrvtvfapdfdfrnplADVAPDVLVAT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 438 SkdgkiSLSDQPLEPLSADFLTAQLSL-QKKDVTASPFTYFKtsyRPHIEQKSYEQLFYNQAGQLLETSIGNLFVQLGRT 516
Cdd:PRK09266 109 S-----PPADGPAGPLRLQSVPYERELpHIKHVGTFGQLHLR---RLAQRAGFDDALFVDPDGRVSEGATWNLGFWDGGA 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 532373748 517 LYTP--PVVVGILPGLFRQELLATGQAQE-KEVTLADLKEASAIFGGNAVRGLYPL 569
Cdd:PRK09266 181 VVWPqaPALPGVTMALLQRGLERLGIPQRtRPVTLADLGRFAGAFACNAWRGQRAV 236
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
491-558 |
2.76e-04 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 42.94 E-value: 2.76e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 532373748 491 EQLFYNQAGQLLETSIGNLFVQLGRTLYTPPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIF 558
Cdd:PRK08320 172 EAIMLNDEGYVAEGTGDNIFIVKNGKLITPPTYAGALEGITRNAVIEIAKElgipvREELFTLHDLYTADEVF 244
|
|
| PRK07101 |
PRK07101 |
hypothetical protein; Provisional |
499-566 |
4.01e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 235934 Cd Length: 187 Bit Score: 41.85 E-value: 4.01e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 499 GQLLETSIGNLFVQLGRTLYTP--PvvvgILPGLFRQELLATGQAQEKEVTLADLKEASAIFGGNAVRGL 566
Cdd:PRK07101 122 GLVTDTSIGNLAFFDGKQWFTPkkP----LLKGTQRARLLDEGKIKEKDITVEDLLQYEEIRLINAMNGF 187
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
385-563 |
8.20e-04 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 41.41 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 385 KHKKIA--FLEQHLNRLKEAATYFAYP-YDEKALQKQLSTYLE-NKD----NAAYRLMIR---LSKDGKISLSdqplEPL 453
Cdd:cd01557 25 PDGKIVlfRPDENAERLNRSARRLGLPpFSVEEFIDAIKELVKlDADwvpyGGGASLYIRpfiFGTDPQLGVS----PAL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 454 SADFLTAqlslqkkdvtASPF-TYFKT-------------------------------SYRPHIE--QKSYEQLFY--NQ 497
Cdd:cd01557 101 EYLFAVF----------ASPVgAYFKGgekgvsalvssfrraapggpgaakaggnyaaSLLAQKEaaEKGYDQALWldGA 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 532373748 498 AGQLLETSIGNLFVQLGRTLYTPPVVVGILPGLFRQELLATGQA-----QEKEVTLADLKEASAIFG-GNAV 563
Cdd:cd01557 171 HGYVAEVGTMNIFFVKDGELITPPLDGSILPGITRDSILELARDlgikvEERPITRDELYEADEVFAtGTAA 242
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
475-563 |
3.07e-03 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 40.30 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532373748 475 TYFKTSYRPHIEQKSY---EQLFYNQAG--QLLETSIGNLFVQLGRTLYTPPVVVGILPGLFRQELLATG-----QAQEK 544
Cdd:PLN03117 201 TNYSPVVKSLIEAKSSgfsDVLFLDAATgkNIEELSACNIFILKGNIVSTPPTSGTILPGVTRKSISELArdigyQVEER 280
|
90 100
....*....|....*....|
gi 532373748 545 EVTLADLKEASAIF-GGNAV 563
Cdd:PLN03117 281 DVSVDELLEAEEVFcTGTAV 300
|
|
| |
