2-hydroxyacyl-CoA dehydratase similar to Escherichia coli YjiM, a putative 2-hydroxyglutaryl-CoA dehydratase encoded in the yjiL-mdtM gene cluster which encodes a bacterial transporter system implicated in the uptake of proline-rich antimicrobial peptides in cells lacking the ABC transporter SbmA
double-cubane-cluster-containing anaerobic reductase; This subfamily of double-cubane proteins ...
14-383
0e+00
double-cubane-cluster-containing anaerobic reductase; This subfamily of double-cubane proteins occurs strictly in anaerobes (facultative or obligate), such as Escherichia coli and Clostridium difficile. The enzyme always co-occurs with an accessory protein, an ATP-dependent activase. The cofactor contains a pair of 4Fe-4S cubane clusters, bridged by a sulfur atom, for an overall 8Fe-9S cofactor structure. However, we observe that that this family essentially always co-occurs in bacteria with SelD, the selenium donor protein required for biosynthesis of selenoproteins, selenouridine-modified tRNAs, selenium-dependent molybdenum hydroxylases, and selenoneine.
:
Pssm-ID: 468731 Cd Length: 372 Bit Score: 655.69 E-value: 0e+00
double-cubane-cluster-containing anaerobic reductase; This subfamily of double-cubane proteins ...
14-383
0e+00
double-cubane-cluster-containing anaerobic reductase; This subfamily of double-cubane proteins occurs strictly in anaerobes (facultative or obligate), such as Escherichia coli and Clostridium difficile. The enzyme always co-occurs with an accessory protein, an ATP-dependent activase. The cofactor contains a pair of 4Fe-4S cubane clusters, bridged by a sulfur atom, for an overall 8Fe-9S cofactor structure. However, we observe that that this family essentially always co-occurs in bacteria with SelD, the selenium donor protein required for biosynthesis of selenoproteins, selenouridine-modified tRNAs, selenium-dependent molybdenum hydroxylases, and selenoneine.
Pssm-ID: 468731 Cd Length: 372 Bit Score: 655.69 E-value: 0e+00
Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 441381 Cd Length: 384 Bit Score: 465.15 E-value: 3.07e-164
2-hydroxyglutaryl-CoA dehydratase, D-component; Degradation of glutamate via the ...
41-382
1.34e-146
2-hydroxyglutaryl-CoA dehydratase, D-component; Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalyzed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate.
Pssm-ID: 461814 Cd Length: 339 Bit Score: 418.62 E-value: 1.34e-146
double-cubane-cluster-containing anaerobic reductase; This subfamily of double-cubane proteins ...
14-383
0e+00
double-cubane-cluster-containing anaerobic reductase; This subfamily of double-cubane proteins occurs strictly in anaerobes (facultative or obligate), such as Escherichia coli and Clostridium difficile. The enzyme always co-occurs with an accessory protein, an ATP-dependent activase. The cofactor contains a pair of 4Fe-4S cubane clusters, bridged by a sulfur atom, for an overall 8Fe-9S cofactor structure. However, we observe that that this family essentially always co-occurs in bacteria with SelD, the selenium donor protein required for biosynthesis of selenoproteins, selenouridine-modified tRNAs, selenium-dependent molybdenum hydroxylases, and selenoneine.
Pssm-ID: 468731 Cd Length: 372 Bit Score: 655.69 E-value: 0e+00
Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 441381 Cd Length: 384 Bit Score: 465.15 E-value: 3.07e-164
2-hydroxyglutaryl-CoA dehydratase, D-component; Degradation of glutamate via the ...
41-382
1.34e-146
2-hydroxyglutaryl-CoA dehydratase, D-component; Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalyzed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate.
Pssm-ID: 461814 Cd Length: 339 Bit Score: 418.62 E-value: 1.34e-146
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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