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Conserved domains on  [gi|535035221|gb|EQR82350|]
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multidrug resistance protein mdtM [Escherichia coli HVH 137 (4-2124971)]

Protein Classification

MFS transporter( domain architecture ID 11487774)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
9-419 0e+00

multidrug efflux MFS transporter MdtM;


:

Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 735.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   9 LMAGLKATHAATLFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRP 88
Cdd:PRK15403   3 RMPRFFARHAATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  89 VLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAA 168
Cdd:PRK15403  83 VLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 169 LMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSP 248
Cdd:PRK15403 163 LMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSP 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 249 VILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLY 328
Cdd:PRK15403 243 VILIDAGGMTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIVGNLLWPHVWLWSVLGTSLY 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 329 AFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 408
Cdd:PRK15403 323 AFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 402

                        410
                 ....*....|.
gi 535035221 409 QHQAAELAEEQ 419
Cdd:PRK15403 403 QHQAAELAEEQ 413
 
Name Accession Description Interval E-value
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
9-419 0e+00

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 735.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   9 LMAGLKATHAATLFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRP 88
Cdd:PRK15403   3 RMPRFFARHAATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  89 VLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAA 168
Cdd:PRK15403  83 VLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 169 LMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSP 248
Cdd:PRK15403 163 LMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSP 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 249 VILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLY 328
Cdd:PRK15403 243 VILIDAGGMTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIVGNLLWPHVWLWSVLGTSLY 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 329 AFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 408
Cdd:PRK15403 323 AFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 402

                        410
                 ....*....|.
gi 535035221 409 QHQAAELAEEQ 419
Cdd:PRK15403 403 QHQAAELAEEQ 413
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 27-403 1.02e-84

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 263.67  E-value: 1.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  27 LILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF 106
Cdd:cd17320    4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 107 TTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMG 186
Cdd:cd17320   84 ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 187 FISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQ 266
Cdd:cd17320  164 LLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLF 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 267 VPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFS 346
Cdd:cd17320  244 ALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEP 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 535035221 347 NNLPKGTVSASLNMVILMVMSVSVEIGRWLWfNGGRLPFHLLAVVAGVIVVFTLAGL 403
Cdd:cd17320  324 FPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 27-368 2.33e-31

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 123.26  E-value: 2.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   27 LILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF 106
Cdd:TIGR00710  10 LGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  107 TTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMG 186
Cdd:TIGR00710  90 SNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  187 FISFVGLLLAMPETVKRGAVSFSAKSVlRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQ 266
Cdd:TIGR00710 170 ILLSALIFFILPETLPYEARIQISTYF-ETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLF 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  267 VPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFS 346
Cdd:TIGR00710 249 ALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALED 328

                         330       340
                  ....*....|....*....|..
gi 535035221  347 NNLPKGTVSASLNMVILMVMSV 368
Cdd:TIGR00710 329 FPHVAGTASALFGTLRLVLGAI 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-339 1.74e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.08  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:COG2814   20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:COG2814  100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 GLLLAMPETVKRGAVSFsaksvLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFG 271
Cdd:COG2814  180 LLLRLLPESRPAARARL-----RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 535035221 272 AVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLiignLLSPHVWLWsVLGTSLYAFGIGLIFPTL 339
Cdd:COG2814  255 GGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL----ALAGSLWLL-LLALFLLGFGFGLLFPLL 317
MFS_1 pfam07690
Major Facilitator Superfamily;
32-340 1.79e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.93  E-value: 1.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   32 FAAYLSTDLIQPGIINVV-RDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSM 110
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  111 TQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISF 190
Cdd:pfam07690  86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  191 VGLLLAMPETVKRGAVSFSAKSVLRDF-RNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAgGLTTSQFAWTQVPV 269
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVaWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLG 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 535035221  270 FGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLgtSLYAFGIGLIFPTLF 340
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL--LLLGFGFGLVFPALN 313
 
Name Accession Description Interval E-value
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
9-419 0e+00

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 735.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   9 LMAGLKATHAATLFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRP 88
Cdd:PRK15403   3 RMPRFFARHAATLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  89 VLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAA 168
Cdd:PRK15403  83 VLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 169 LMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSP 248
Cdd:PRK15403 163 LMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSP 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 249 VILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLY 328
Cdd:PRK15403 243 VILIDAGGMTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIVGNLLWPHVWLWSVLGTSLY 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 329 AFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 408
Cdd:PRK15403 323 AFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVR 402

                        410
                 ....*....|.
gi 535035221 409 QHQAAELAEEQ 419
Cdd:PRK15403 403 QHQAAELAEEQ 413
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
20-414 3.46e-134

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 390.84  E-value: 3.46e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  20 TLFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTL 99
Cdd:PRK15402  11 ALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 100 ACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLF 179
Cdd:PRK15402  91 TCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 180 AIIAIMGFISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTT 259
Cdd:PRK15402 171 VLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVILISGEQLSS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 260 SQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTL 339
Cdd:PRK15402 251 YEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFGIGLANAGL 330

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 340 FRFTLFSNNLPKGTVSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLLNRVRQHQAAE 414
Cdd:PRK15402 331 YRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGNAHE 405
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 27-403 1.02e-84

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 263.67  E-value: 1.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  27 LILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF 106
Cdd:cd17320    4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 107 TTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMG 186
Cdd:cd17320   84 ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 187 FISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQ 266
Cdd:cd17320  164 LLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLF 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 267 VPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFS 346
Cdd:cd17320  244 ALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEP 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 535035221 347 NNLPKGTVSASLNMVILMVMSVSVEIGRWLWfNGGRLPFHLLAVVAGVIVVFTLAGL 403
Cdd:cd17320  324 FPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 27-368 2.33e-31

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 123.26  E-value: 2.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   27 LILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF 106
Cdd:TIGR00710  10 LGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  107 TTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMG 186
Cdd:TIGR00710  90 SNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  187 FISFVGLLLAMPETVKRGAVSFSAKSVlRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQ 266
Cdd:TIGR00710 170 ILLSALIFFILPETLPYEARIQISTYF-ETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLF 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  267 VPVFGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFS 346
Cdd:TIGR00710 249 ALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALED 328

                         330       340
                  ....*....|....*....|..
gi 535035221  347 NNLPKGTVSASLNMVILMVMSV 368
Cdd:TIGR00710 329 FPHVAGTASALFGTLRLVLGAI 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-339 1.74e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.08  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:COG2814   20 FLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:COG2814  100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 GLLLAMPETVKRGAVSFsaksvLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFG 271
Cdd:COG2814  180 LLLRLLPESRPAARARL-----RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 535035221 272 AVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLiignLLSPHVWLWsVLGTSLYAFGIGLIFPTL 339
Cdd:COG2814  255 GGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL----ALAGSLWLL-LLALFLLGFGFGLLFPLL 317
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
36-335 1.22e-25

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 106.92  E-value: 1.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  36 LSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLI 115
Cdd:PRK11102   5 LAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 116 ARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLL 195
Cdd:PRK11102  85 MRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 196 AMPETVKRGA-VSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVI 274
Cdd:PRK11102 165 FIPETLPKERrQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFLF 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 535035221 275 VANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLspHVWLWS-VLGTSLYAFGIGLI 335
Cdd:PRK11102 245 VMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALL--DLGFWAlVVGVAAFVGCVSMI 304
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
35-255 1.86e-22

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 98.43  E-value: 1.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  35 YLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGgMAL-QWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQF 113
Cdd:PRK11043  19 FLATDMYLPAFKAIQADLQTSASAVSASLSLFLAG-FALgQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 114 LIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFIsFVGL 193
Cdd:PRK11043  98 LVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLL-LILP 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 535035221 194 LLAMPETVKRGAVSFSAKSVLRDFRN-VFCNRQFLFGAATISLsyipmMSWVAVSPVILIDAG 255
Cdd:PRK11043 177 TLRLKPSKKARKQSQDALTFKQLLKSkTYLGNVLIFAACSAAF-----FAWLTGSPFILEQMG 234
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
39-263 6.33e-22

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 96.63  E-value: 6.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  39 DLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARA 118
Cdd:PRK10473  20 DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRF 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 119 IQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMP 198
Cdd:PRK10473 100 LQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILK 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 199 ETvkRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFA 263
Cdd:PRK10473 180 ET--RPARAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGEYA 242
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 32-400 2.02e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 91.87  E-value: 2.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17325   86 QLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 GLLLAMPETVKRGA-VSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWtqvpVF 270
Cdd:cd17325  166 LALLLLPEPRPPPNkRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL----LF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 271 GAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWsVLGTSLYAFGIGLIFPTLfrFTLFSNNLP 350
Cdd:cd17325  242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL-LLLLALLGLGLGLVFPAT--LALLADIVP 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 535035221 351 K---GTVSASLNMVILMVMSVSVEIGRWLW-FNGGRLPFHLLAVVAGVIVVFTL 400
Cdd:cd17325  319 PegrGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFL 372
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-400 7.20e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 87.48  E-value: 7.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:cd06174    6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAAL--MHFVHWKVLFAIIAIMGFIS 189
Cdd:cd06174   86 LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 190 FVGLLLAMPETVKRGAV---SFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQ 266
Cdd:cd06174  166 AILLLLVVPDPPESARAkneEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 267 VPVFGAVIVANAIVARFVKDPTEPRFIWravPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFS 346
Cdd:cd06174  246 SLFGLAGALGSLLLGLLSDRLIGRKPLL---LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 535035221 347 NNLPKGTVSASLNMVILMVMSVSVEIGRWLW--FNGGRLPFHLLAVVAGVIVVFTL 400
Cdd:cd06174  323 PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLTGAFLVLAVLLLLAAILLL 378
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 32-404 1.75e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 86.45  E-value: 1.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:cd17324    9 FAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17324   89 LLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 GLLLAMPETVKRGAVSFsakSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFG 271
Cdd:cd17324  169 LLWRLLPSLPPKKPGSL---GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 272 AVIVANAIVARFVKdptepRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFSNNLPK 351
Cdd:cd17324  246 AGVVGSPLAGRLAD-----RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 535035221 352 GTVSaSLNMVILMV-MSVSVEIGRWLWFNGGrlpfhlLAVVAGVIVVFTLAGLL 404
Cdd:cd17324  321 GLAS-SLYLAAYNLgGALGAALGGLVLDHGG------WAGVGWVGAALLLLALL 367
MFS_1 pfam07690
Major Facilitator Superfamily;
32-340 1.79e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.93  E-value: 1.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   32 FAAYLSTDLIQPGIINVV-RDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSM 110
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  111 TQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISF 190
Cdd:pfam07690  86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  191 VGLLLAMPETVKRGAVSFSAKSVLRDF-RNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAgGLTTSQFAWTQVPV 269
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVaWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLG 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 535035221  270 FGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLgtSLYAFGIGLIFPTLF 340
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL--LLLGFGFGLVFPALN 313
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 48-361 7.04e-18

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 84.53  E-value: 7.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  48 VVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:cd17321   22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 128 ATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAImgfISFVGLLLAmpetvkrgavs 207
Cdd:cd17321  102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP---IGLVALLLA----------- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 208 fsaksvlrdfrnvfcnRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKdp 287
Cdd:cd17321  168 ----------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD-- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 288 teprfIWRAVPIQLVGLALLIIGNLL----SPHVWLWSVL-GTSLYAFGIGLIFPTLFRFTLfsNNLPK---GTVSASLN 359
Cdd:cd17321  230 -----RFGPRLVLVAGLLLTAVGLLLlallGADSSVWLLLpGLVLLGLGLGLFATPLTNAAL--SSVPKekaGAASGILN 302


                 ..
gi 535035221 360 MV 361
Cdd:cd17321  303 TA 304
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 32-284 1.07e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 79.86  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:COG0477   24 FLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:COG0477  104 LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 gLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFG 271
Cdd:COG0477  184 -LRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262

                        250
                 ....*....|...
gi 535035221 272 AVIVANAIVARFV 284
Cdd:COG0477  263 LLLLLLLLLLALL 275
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 48-401 1.77e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 80.31  E-value: 1.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  48 VVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:cd17474   25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 128 ATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFvHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVs 207
Cdd:cd17474  105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLPEPKEKAKS- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 208 fSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDP 287
Cdd:cd17474  183 -SSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 288 TEPRFIwraVPIQLVGLALLIIGNLLSPHVWlWSVLGTSLYAFGIGLIFPTLFRF-TLFSNNLPKGTVSASLNMVILMVM 366
Cdd:cd17474  262 FGARRI---LVIGLLLYALSLLLLGFVPSLA-LLLIAIVLFGLGLGLNLPLLTTLvTELAPEEERGTASSLYNFVRFLGQ 337

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 535035221 367 SVS-VEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLA 401
Cdd:cd17474  338 AVGpLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 32-340 2.41e-15

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 76.85  E-value: 2.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:cd17323    9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17323   89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLI 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 GLLLAMPETVKRGAVSFSAKSVLRDFRNVFCN---RQFLFGAATISLSYIPMMswvaVSPVILIDAGGLTTSQFAWTqvp 268
Cdd:cd17323  169 LIFLFLPIVLLLGLYVGLVYAILYLFLTAFPYvfgEVYGFSPGEVGLMYLPIG----IGALIGSIIGGRLSDYYYRR--- 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 535035221 269 vfgavivanAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGNLLSPHV-WLWSVLGTSLYAFGIGLIFPTLF 340
Cdd:cd17323  242 ---------LKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIhWIVPIIGSAFFGFGLMLIFQSSL 305
emrD PRK11652
multidrug transporter EmrD;
43-339 2.67e-15

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 76.87  E-value: 2.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  43 PGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGT 122
Cdd:PRK11652  29 PAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 123 SICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVK 202
Cdd:PRK11652 109 GTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRP 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 203 RGAvsfSAKSVLRDFRNVFCNRQFLfgAATISLsyIPMMSWVAV----SPVILIDAGGLTTSQFAWTQV-PV----FGAV 273
Cdd:PRK11652 189 ADA---RRTRVLASYRTLLSNRRFN--CYLLML--IGTLAGIAVfeacSGVLMGAVLGLSSMTVSILFIlPIpaafFGAW 261

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 535035221 274 IvANAIVARFvkdptePRFIWRAVPIQLVGLALLIIGNLLSPhVWLWSVL-GTSLYAFGIGLIFPTL 339
Cdd:PRK11652 262 F-AGRPNKRF------STLMWQSVICCLLAGLLMWIPGWFGV-MNVWTLLvPAALFFFGAGMLFPLA 320
2_A_01_02 TIGR00880
Multidrug resistance protein;
63-200 8.74e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.14  E-value: 8.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   63 VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQT 142
Cdd:TIGR00880   4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 535035221  143 KGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPET 200
Cdd:TIGR00880  84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 80-404 6.28e-14

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 72.61  E-value: 6.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  80 LSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAP 159
Cdd:cd17503   54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 160 IIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAmpetvkrgavsfsaksvlrDFRnVFCNRQFLFGAATISLSYIP 239
Cdd:cd17503  134 AIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL-------------------DLR-LFKDRNFTLGLLLSFLLGLG 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 240 MMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVkDPTEPRfiwravPIQLVGLALLIIGNLLSPHV-- 317
Cdd:cd17503  194 LFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLL-DKFGPR------LLLLAGLLLLALGTLLLAFLtp 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 318 ---WLWSVLGTSLYAFGIGLIFPTLfrFTLFSNNLPK---GTVSASLNMVILMVMSVSVEI-----GRWLWFNGGRLPFH 386
Cdd:cd17503  267 dtsLWLIILPLFIRGLGMGLVFMPL--NTLALNSLPPeqiGDATALFNTIRQLGGSIGTALlatllTNRTQFHHSRLSEL 344

                        330       340
                 ....*....|....*....|....
gi 535035221 387 LL------AVVAGVIVVFTLAGLL 404
Cdd:cd17503  345 LAqqvqkqALIIAFNDAFLVSAIL 368
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
48-400 1.14e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.82  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  48 VVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:COG2271   36 LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 128 ATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGlllampetvkrgavs 207
Cdd:COG2271  116 FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL--------------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 208 fsaksvlrdfrnvfcnrQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKdp 287
Cdd:COG2271  181 -----------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD-- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 288 tepRFIWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFSNNLPK---GTVSASLNMVILM 364
Cdd:COG2271  242 ---RLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKkarGTASGLVNTFGFL 318

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 535035221 365 VMSVS-VEIGRWLWFNGGRLPFHLLAVVAGVIVVFTL 400
Cdd:COG2271  319 GGALGpLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 32-339 8.45e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 69.16  E-value: 8.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17489   86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 192 GLLLAMPETVKRGAVSFSAKSVLRDFRnvfcNRQFLFGAATISLSYIPMMSWVAVSPV----ILIDAGGLTTSQFAwtqv 267
Cdd:cd17489  166 LVFLVKDPPPVAAEEAEAGTRAFRRLV----EKKVLPPALILFLASIAYGAISTFLPLyaaeRGISNAGLFFTVYA---- 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 535035221 268 pvfGAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIIGnllspHVWLWSVLGTSLYAFGIGLIFPTL 339
Cdd:cd17489  238 ---IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA-----GSPWMLLLAAVLYGLGFGLLFPAL 301
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
62-343 2.87e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 67.60  E-value: 2.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  62 AVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQ 141
Cdd:COG2223   45 LFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 142 TKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVsfSAKSVLRDFRNVF 221
Cdd:COG2223  125 DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA--AAKASLRDQLEAL 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 222 CNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWtqvpvFGAVIVANAIVARFVKDPTEPRF-IWRAVPIQ 300
Cdd:COG2223  203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL-----LAALFALLGALGRPLGGWLSDRIgGRRVLLIV 277

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 535035221 301 LVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFT 343
Cdd:COG2223  278 FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV 320
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 73-400 3.44e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 67.24  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  73 LQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGtsICFIATVGYVTVQEAFGQTKGIRLMAIIT 152
Cdd:cd17472   48 FQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 153 SIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAAT 232
Cdd:cd17472  126 ASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFI 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 233 ISLSYipMMSWVAVsPVILIDAGGLTTSQFaWTQVPVFGAVIVANAIVARFVKDPTEPrfiWRAVPIQLVGLALLIIGNL 312
Cdd:cd17472  206 LHFVL--MAFFYIL-PLLLTQLGGGKGQLW-KVYLPAILIGFILMVPFVIYAEKKGKM---KQVFVSSILLIAVGFLLLL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 313 LSPHVWLWSVLGTSLYAFGIGLIFPTLFRF-TLFSNNLPKGTVSASLNMVILMVMSVSVEIGRWLW-FNGGRLPFHLLAV 390
Cdd:cd17472  279 FAATSLWLLIIGLIIFFIGFNLLEALLPSLvSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWgLLGYSSVFLTILI 358

                        330
                 ....*....|
gi 535035221 391 VAGVIVVFTL 400
Cdd:cd17472  359 LALLWLLVSF 368
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 47-340 3.67e-12

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 66.82  E-value: 3.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  47 NVVRDFNaDVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICF 126
Cdd:cd17502   21 TIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 127 IATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLllampetvkrgav 206
Cdd:cd17502  100 LMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL------------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 207 sfsaksvlrdfrnvfcnRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVkd 286
Cdd:cd17502  167 -----------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI-- 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 287 ptepRFIWRAVPIQLVGLALLIIGNLL------SPHVWLWSVLGTsLYAFGIGLIFPTLF 340
Cdd:cd17502  228 ----SKTGRYKPLIVIGTILMSVGAGLlttltlDTSKWLLIGYLI-LLGLGLGIGFQQPL 282
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 76-340 1.01e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 66.06  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  76 LLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIV 155
Cdd:cd17473   54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 156 LIAPIIGPLSGAALMHFvHWKVLFAIIAImGFISFVGLLLAMPETVKRGAVSFSAKSVLRDfrnVFCNRQFLFGAATISL 235
Cdd:cd17473  134 SLGGVVFLLLGGALAEI-GWRAPFLVYLL-ALPVLILVLLFLPEPARKSKSAASPGAATAA---ALPWKRVLPIYFLAFL 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 236 SYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTEPRFIwrAVPIQLVGLALLIIGnlLSP 315
Cdd:cd17473  209 AMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL--AIGFALMALGFLLLA--LAS 284

                        250       260
                 ....*....|....*....|....*
gi 535035221 316 HVWlWSVLGTSLYAFGIGLIFPTLF 340
Cdd:cd17473  285 GLW-VVLLGAILAGLGFGLLLPTLN 308
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
48-400 1.01e-11

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 66.05  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  48 VVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:COG2807   44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 128 ATVGYVTVQEAFGQTKGiRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVS 207
Cdd:COG2807  124 NVLLPGLIKRWFPDRVG-LMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 208 FSAKSVLRDFRNVFCnRQFLFGAATISLSYIPMMSWVavsPVILIDAG------GLTTSQFAWTQVPvfgAVIVANAIVA 281
Cdd:COG2807  203 PAAASLRSLWRSPLA-WLLTLFFGLQSLLYYAVVAWL---PPILRDAGlsaataGLLLSLFQLAGIP---GSLLVPLLAD 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 282 RFvkdPTEPRFIWRAVPIQLVGLALLiignLLSPHVWLWsvLGTSLYAFGIGLIFPTLfrFTLFSNNLPKGTVSASLNMV 361
Cdd:COG2807  276 RL---GDRRPLLLLLGLLGLAGLLGL----LLAPGSLPW--LWAVLLGLGQGGLFPLA--LTLIGLRARTPAEAAALSGM 344

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 535035221 362 ILMVMSVSVEIGRWL------WFNGGRLPFHLLAVVAGVIVVFTL 400
Cdd:COG2807  345 AQSVGYLLAALGPLLvgalhdATGSWTAALLLLAALAVLMLVAGL 389
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
36-402 2.44e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.88  E-value: 2.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  36 LSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLI 115
Cdd:COG0738   22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 116 ARAIQGTSICFIATVGYVTVQEAFGQTKGiRLMAIITSIVLIAPIIGPLSGAALMHF---VHWKVLFAIIAIMGFISFVG 192
Cdd:COG0738  102 ALFLLGLGLGLLDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 193 LLLA-MPETVKRGAvsfSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWtqvpvFG 271
Cdd:COG0738  181 FLRSkLPEIEEEEE---EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAAL-----GL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 272 AVIVANAIVARFVKDPTEPRF-IWRAVPIQLVGLALLIIGNLLSPHVWLwSVLGTSLYAFGIGLIFPTLFRFTLfsNNLP 350
Cdd:COG0738  253 SLFWGGMTIGRFLGGFLLKRFgPVRLLRLSALLAAVGLLLALLAPGPWL-ALIGLALVGLGLSLMFPTIFSLAL--DGLG 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 351 KGT---VSASLNMVILMVMSVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAG 402
Cdd:COG0738  330 KRTaaaVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 51-191 2.64e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.38  E-value: 2.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  51 DFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATV 130
Cdd:cd17316   30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 131 GYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVH----WKVLFAIIAIMGFISFV 191
Cdd:cd17316  110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLALL 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 50-400 3.15e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 57.97  E-value: 3.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  50 RDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIAT 129
Cdd:cd17330   27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 130 VGyVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETvkrgavsfs 209
Cdd:cd17330  107 AQ-AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPL--------- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 210 aksvlrdfrnvfcnRQFLFGAATISLSYIPMMSwvaVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTE 289
Cdd:cd17330  177 --------------RRLLLVYFLIALAFAGLES---VFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 290 PRFIWRAvpiqlvGLALLIIGNLLSPHVWL--WSVLGTSLYAFGIGLIFPTLfrFTLFSNNLPKGtVSASLNMVILMVMS 367
Cdd:cd17330  240 ERKLLRL------GLLLAIIGLLLLPFASSvpLLVLAAAILAFGTGIVFPAL--SALLSKSVPSK-EQGKAQGIIQSLQS 310

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 535035221 368 VSVEIGRWLW-----FNGGRLPFHLLAVVAGVIVVFTL 400
Cdd:cd17330  311 LARIIGPLLAgplysFLGPGVPFLLAAGLLLIALFLLS 348
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 50-340 4.31e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 57.58  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  50 RDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIAT 129
Cdd:cd17319   31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 130 VGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVkrgavsfs 209
Cdd:cd17319  111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW-------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 210 aksvlrdfrnvfcnrQFLFGAATISLSYIPMMSWVavsPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDpte 289
Cdd:cd17319  183 ---------------GLALGYFGINYALYGLLTWL---PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR--- 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 535035221 290 pRFIWRAVPIQLVGLALLIIGNLLSPHVW--LWSVLGTSLYAFGIGLIFPTLF 340
Cdd:cd17319  242 -LLRGARRLVIIIGLLLAAVGLLLAYLTTspVVAVILLSLAGFGIGAASPVFW 293
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 32-357 6.63e-09

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 57.33  E-value: 6.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  32 FAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT 111
Cdd:cd17333    6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 112 QFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRlMAIITSIVLIAPIIGPL-SGAALMHFVHWKVLFAIIAIMGFISF 190
Cdd:cd17333   86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATR-LNVLHGFFGLGALIGPLiATSLLTSELSWSWAYLIIGLIYLLLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 191 VGLLLAM-PETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLtTSQFAWTQVPV 269
Cdd:cd17333  165 ILILLTLfPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV-SDGLAGYLLSG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 270 FGAVIVANAIVARFVKDPTEPrfiWRAVPIQLVGLALLIIGNLLSPHVwLWSVLGTSLYAFGIGLIFPTLfrFTLFSNNL 349
Cdd:cd17333  244 FWVGITIGRLLGGPISRRIKP---HTLLVLSGSGALLGLLILLLAPTL-VVGLVATALLGLFMAALFPTI--LSLGISNL 317


                 ....*...
gi 535035221 350 PKGTVSAS 357
Cdd:cd17333  318 PYAKGKGT 325
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
49-202 3.42e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.88  E-value: 3.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  49 VRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRR--PVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICF 126
Cdd:COG2271  208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 535035221 127 IATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVK 202
Cdd:COG2271  288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 27-346 6.15e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 54.12  E-value: 6.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  27 LILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF 106
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 107 TTSMTQFLIARAIQGTSICfIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMG 186
Cdd:cd17504   81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 187 FISFVGLLLAMPETVKRGAVSFSAKSVlrdfrnvfcnrqFLFGAATISLSYIpmMSWVAVSPVILidAGGLTTSQFAWTQ 266
Cdd:cd17504  160 VLLAALVPLIDLRLLRRRNVLLANITA------------LLAGFGMFMVFQL--LPQLLQLPTPT--GFGLGITEAGLLL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 267 VPVFGAVIVANAIVARFVkdptePRF-IWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLF 345
Cdd:cd17504  224 LPGALVMLIAGPLAGRLI-----ARVgPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVE 298


                 .
gi 535035221 346 S 346
Cdd:cd17504  299 S 299
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 52-407 6.97e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.16  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  52 FNADVSLAPAAVSLYLA----GGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:cd17329   26 LHQQLGLSASIVGLVLAlsavAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 128 ATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFvHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVS 207
Cdd:cd17329  106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 208 fSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDp 287
Cdd:cd17329  185 -EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVER- 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 288 teprfiWRAVPIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFSNNLPKGTVsASLNMVILMVMS 367
Cdd:cd17329  263 ------FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKR-GSYMGFYALAWG 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 535035221 368 VSVEIGRWLwfnGGRLPFH----LLAVVAGVIVVFTLAGLLNRV 407
Cdd:cd17329  336 LGRAIGPLV---GGLLLDLlgpgLPWLILAALGLIAAALLLGLQ 376
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 48-191 1.10e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 53.36  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  48 VVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:cd17365   25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 535035221 128 ATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17365  105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 21-214 1.45e-07

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 53.54  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   21 LFFPMALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLA 100
Cdd:TIGR00711   1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  101 CAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFA 180
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 535035221  181 IIAIMGFISFVGLLLAMPETVKRGAVSFSAKSVL 214
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASENFDFLGLL 194
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
76-340 1.52e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.37  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  76 LLGPLSDRIG-----RRPVLITGALIFTLACAATMFTTSMTQflIARAIQGTSICFIATVGYVTVQEAFG---------Q 141
Cdd:COG2211   65 LIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSP--TGKLIYALVTYLLLGLAYTLVNIPYSalgaeltpdY 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 142 TKGIRLMAIITSIVLIAPIIGPLSGAALMHFV------HWKVLFAIIAIMGFISFVGLLLAMPEtvkRGAVSFSAKSVLR 215
Cdd:COG2211  143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKE---RPVPEEEKVSLKE 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 216 DFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKdPTEPRFIWR 295
Cdd:COG2211  220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK-RFGKKKAFI 298

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 535035221 296 AvpIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFPTLF 340
Cdd:COG2211  299 I--GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPW 341
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 26-404 2.02e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 52.62  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  26 ALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLIT-----GALIFTLA 100
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 101 CAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFA 180
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 181 IIAIMGFISFVGLLL--AMPETVKRGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLT 258
Cdd:cd06173  163 INALSFLLSALLLLFirRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 259 TSQFAWTQVPVFGAVIVANAIVARFVKdptePRFIWRAVPIQLVGLALLIIGNLLSPHVWLwSVLGTSLYAFGIGLIFPT 338
Cdd:cd06173  243 AAGYGLLLAAFGVGALLGALLLGRLSK----RRRRGRLLLIGALLLGLALLVLGLSPSLWL-LLAALFLLGLAGGLFNVP 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 535035221 339 LfrFTLFSNNLPK---GTVSASLNMVILMVMSVSVEIGRWLwfnGGRLPFHLLAVVAGVIVVFTLAGLL 404
Cdd:cd06173  318 L--NTLLQLRVPDelrGRVFSVYNALNSGAMPLGALLAGLL---ADALGLSAVFLLAGALLLLAALLLL 381
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 51-202 2.51e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.36  E-value: 2.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   51 DFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATV 130
Cdd:TIGR00895  46 EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPN 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 535035221  131 GYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVK 202
Cdd:TIGR00895 126 LNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESID 197
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 58-191 2.54e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.20  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  58 LAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQE 137
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 535035221 138 AFGqTKGIRLMAIITSIVLIAPIIGpLSGAALMhFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17317  106 IVG-PKYRSFVGILFGLFWALGYML-LALLAYL-IRDWRWLQLAISLPGLLFLL 156
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 52-195 3.62e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.81  E-value: 3.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  52 FNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVG 131
Cdd:cd17325  230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 535035221 132 YVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLL 195
Cdd:cd17325  310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
PRK10504 PRK10504
putative transporter; Provisional
 78-198 1.18e-06

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 50.50  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  78 GPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIVLI 157
Cdd:PRK10504  66 GWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQV 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 535035221 158 APIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMP 198
Cdd:PRK10504 146 GPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMP 186
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 51-140 1.41e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.99  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  51 DFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATV 130
Cdd:cd17371   28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAA 107

                         90
                 ....*....|
gi 535035221 131 GYVTVQEAFG 140
Cdd:cd17371  108 GAALMAEYVP 117
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 50-200 2.31e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 49.49  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  50 RDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIAR-----AIQGTSI 124
Cdd:cd17359   29 TDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARiigglAVGGASA 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 535035221 125 CFIATVGYVTVQEAFGQTKGIRLMAIITSIVL---IAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLaMPET 200
Cdd:cd17359  109 LVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLayiVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF-IPES 186
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 49-338 5.58e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 48.04  E-value: 5.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  49 VRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQG--TSICF 126
Cdd:cd17355   30 IAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGggGAGTL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 127 IATVGYVTVQEAFGQTKGiRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAM----PETVK 202
Cdd:cd17355  110 AAVAFATVAAWWFERRRG-LALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLrrrpADLAL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 203 RGAVSFSAKSVLRDFRNVFCNRQFLFGAATISLSYIPMMSWVAVSPVILIDAgGLTTSQFAWTqVPVFGAVIVANAIVAR 282
Cdd:cd17355  189 RAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVA-LALIGLFNIVGRLLSG 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 535035221 283 FVKDPTEPRFIWRAV-PIQLVGLALLIIGNLLSPHVWLWSVlgtsLYAFGIGLIFPT 338
Cdd:cd17355  267 WLGDRYSPRRLLAASyALRALGLALLLLLPFPPLALLLFAA----LFGLGWGATVPL 319
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 26-195 5.69e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 48.39  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  26 ALILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGmALQWLLGPLSDRIGRRPVLITGALIFTLACAATM 105
Cdd:cd06179    2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQA-VLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 106 FTTSMTQFLIARAIQGTSICfIATVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVH--WKVLFAIIA 183
Cdd:cd06179   81 TAKSVNMLIGGQALIGIGAG-TQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINA 159

                        170
                 ....*....|..
gi 535035221 184 IMGFISFVGLLL 195
Cdd:cd06179  160 IFNALALILLFF 171
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 22-195 1.75e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 46.85  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  22 FFPMALILYDFAAylstDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLAC 101
Cdd:cd17313  250 FFPFELFFTDYMG----EEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGM 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 102 AATMFTTSMTQFLIARAIQGTSICFIATVGY-VTVQEAFGQTKGIRL-MAIITSIVLIAPIIGPLSGAALMHFVHWKVLF 179
Cdd:cd17313  326 ALMALVHNVTVALVLFALGGIGWATININPYpLVSDYHSESGRGQGTdTGLLNLAISLAQILVSLLAGPIIDVKGYGTVF 405

                        170
                 ....*....|....*.
gi 535035221 180 AIIAIMGFISFVGLLL 195
Cdd:cd17313  406 PVAAVASFLSLVGALF 421
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 69-219 2.23e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 46.41  E-value: 2.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  69 GGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAfgQTKGIRlm 148
Cdd:cd17358   53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEI--APKNVR-- 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 149 AIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLaMPET----VKRGAVSfSAKSVLRDFRN 219
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGSFLPWRTLALIGAIPPVVFLILLFF-IPESprwlAKKGREE-EAEKSLQFLRG 201
DUF2623 pfam11115
Protein of unknown function (DUF2623); This family is conserved in the Enterobacteriaceae ...
 1-20 2.45e-05

Protein of unknown function (DUF2623); This family is conserved in the Enterobacteriaceae family. Several members are named as YghW. The function is not known.


Pssm-ID: 431663  Cd Length: 93  Bit Score: 42.89  E-value: 2.45e-05
                          10        20
                  ....*....|....*....|
gi 535035221    1 MNNHFGKGLMAGLKATHAAT 20
Cdd:pfam11115   1 MGNHFGKGLLAGLQASNPDS 20
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 55-191 7.79e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 7.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  55 DVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMT-QFLIARAIQGTSICFIATVGYV 133
Cdd:cd17477  221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPlALLVLLFLWGGAAGPLYTLALA 300

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 535035221 134 TVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFV 191
Cdd:cd17477  301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 61-142 8.50e-05

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 44.38  E-value: 8.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  61 AAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFG 140
Cdd:cd17377   43 LASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVG 122


                 ..
gi 535035221 141 QT 142
Cdd:cd17377  123 KS 124
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 44-195 2.14e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.92  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  44 GIINVVR--DFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAI-Q 120
Cdd:cd17352   23 GVLFVELleEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVlG 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 121 GTSICFIATVGYVTVQEAFgQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLL 195
Cdd:cd17352  103 GLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL 176
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 55-264 2.53e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  55 DVSLAPAAVSLYLA----GGMALQWLLGPLSDRIG-RRPVLITGALIFTLACAATMFTTSMTQFLIA----RAIQGTSIC 125
Cdd:cd17471   26 ELGASPLQIGIFMTlsalSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLVgvvlLSLGAAAFP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 126 FIATVGYVTVQEAFGQtKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVgLLLAMPETVKRGA 205
Cdd:cd17471  106 QLFALAREYADRSSGR-DATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVAL-LVLFLLPSVKPPA 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 535035221 206 VSFSAKSVLRDFRNvfcNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGLTTSQFAW 264
Cdd:cd17471  184 QKATPASSLVKAPV---NRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL 239
Sugar_tr pfam00083
Sugar (and other) transporter;
46-200 3.81e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 42.64  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   46 INVVRDFNADVSLAPAA---------VSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLA---CAATMFTTSMTQF 113
Cdd:pfam00083  26 IDFFKNFGLSKSVSSLAalsvlsgliVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGavlQGAAKGKWSVYQL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  114 LIARAIQGTSICFIATVGYVTVQE-----AFGQTKGIRLMAIITSIVLiapiiGPLSGAALMHF---VHWKVLFAIIAIM 185
Cdd:pfam00083 106 IVGRVLVGIGVGGASVLAPMYISEiapkkLRGALGSLYQLAITFGILL-----AYIFGLGLNKTsnsDGWRIPLGLQLVP 180

                         170
                  ....*....|....*
gi 535035221  186 GFISFVGLLLAmPET 200
Cdd:pfam00083 181 ALLLIIGLLFL-PES 194
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 46-200 4.09e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.18  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  46 INVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSIC 125
Cdd:cd17315   23 IAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVG 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 535035221 126 FIATVGYVTVQEAFGQTKGIRLMAI----ITSIVLIAPIIGplSGAALMHFVHWKVLFAIIAIMGFIsFVGLLLAMPET 200
Cdd:cd17315  103 LASVLVPLYISEIAPAKIRGALGTLnqlmITFGILLAYLLG--LALSLSPPGWWRLMFALAAVPALL-QLLLMFFLPES 178
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 49-339 5.18e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.82  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  49 VRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF-TTSMTQFLIARAIQGTSICF- 126
Cdd:cd17490   23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMIlFPSPWGLLIARFLSGIAAATw 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 127 -IATVGYVTVQEAFGQTKGirlMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGA 205
Cdd:cd17490  103 vSFTVLYASYFPPDEAAKA---MGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 206 VSFSAKSVLRDFRNvfcNRQFLFGAATISLSYIPMMSWVAVSPVILIDAGGlTTSQFAWTQVpvfgAVIVANAIVARFVK 285
Cdd:cd17490  180 VLTELKELLSVLKD---KKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGA-SSFQLGLLSI----IYLLPNALASLLSG 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 535035221 286 DPTEPRFIWR-AVPIQLVGLALLIIGNLLSPHVWLWSVLgTSLYAFGIGLIFPTL 339
Cdd:cd17490  252 TLFYKKLGERnTIIIGFLLLGAYCFLIPFAPNLTLLYLL-QALNGFGTGILFPLL 305
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 78-197 6.11e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 41.86  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  78 GPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAF--GQTKGIrLMAIITSIV 155
Cdd:cd17476   54 GRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYppGPRKNI-VFSLFGATA 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 535035221 156 LIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAM 197
Cdd:cd17476  133 PLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWT 174
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 76-200 8.00e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 41.49  E-value: 8.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  76 LLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQG-----TSICfIATVGYVTVQEAFGqtKGirlMAI 150
Cdd:cd17389   83 ITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGiskgnVSLS-TAIVADVTSPKKRS--KG---MAL 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 535035221 151 ITSIVLIAPIIGPLSGA-----ALMHFVHWKVLFAIIAIM-GFISFVGLLLAMPET 200
Cdd:cd17389  157 IGVAFSLGFIIGPMIGAyfasfTRSLGEVFFSMPALFALVlALADLLFIFFFLPET 212
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 54-191 8.93e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 8.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   54 ADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYV 133
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 535035221  134 TVQEAFGqtKGIRLMAIITSIVLIApiIGPLSGAALMHFV-HWKVLFAIIAIMGFISFV 191
Cdd:TIGR00898 204 LNTEFLP--KKQRAIVGTLIQVFFS--LGLVLLPLVAYFIpDWRWLQLAVSLPTFLFFL 258
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 76-216 1.06e-03

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 41.02  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  76 LLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAF-GQTKGIRLMAIITSI 154
Cdd:cd17384   50 IVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYpDDKERGKAMGIALGG 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 535035221 155 VLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLAMPETVKRGAVSFSA--KSVLRD 216
Cdd:cd17384  130 LALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTpwKTLLKD 193
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 49-194 1.10e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  49 VRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIA 128
Cdd:cd17370  226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 535035221 129 TVGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLL 194
Cdd:cd17370  306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 57-233 1.26e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 40.74  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  57 SLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTL-----ACAATMFTTSMTQFLIARAIQGTSI-CFIATV 130
Cdd:cd17374   35 SLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIfgtcaAFAPTFPVYCVLRFLAGFAVSGISInTLILGT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 131 GYVTVQEafgqtkgiRLMAIITSIVLIAPIIGPLSGAALMhFVHWKVLFAIIAIMGFISFVgLLLAMPE-----TVKRGA 205
Cdd:cd17374  115 EWTTPRH--------RALAITLTSCFFSIGQMLLAGLAYA-IRDWRLLQLVVSVPFFLFFL-YSWWLPKrtlilSFVWFA 184

                        170       180       190
                 ....*....|....*....|....*....|.
gi 535035221 206 VSFSAKSVLRDFRNVFCN---RQFLFGAATI 233
Cdd:cd17374  185 NSFSYYGLSLDLQHLGLNvflLQFLFGAVEV 215
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 76-196 1.32e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.68  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  76 LLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTKGIRLMAIITSIV 155
Cdd:cd06173  263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 535035221 156 LIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLLA 196
Cdd:cd06173  343 SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 64-189 1.58e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.81  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   64 SLYLAGGMALQWLLGPLSDRIGRRPVLITGALI----FTLACAATMFTT---SMTQFLIARAIQGTSICFIATVgyvtvq 136
Cdd:pfam06609  85 TLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIglvgAIVGCTANKFNTllaAMTLLGVAAGPAGASPLFIGEL------ 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 535035221  137 eAFGQTKGIRLMaIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFIS 189
Cdd:pfam06609 159 -MSNKTKFLGLL-IVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIA 209
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 50-234 2.07e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 40.30  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  50 RDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIAT 129
Cdd:cd17328   27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 130 VGYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAAL-MHFVHWKVLFAIIAIMGFIsFVGLLLAMPETVKRGA--- 205
Cdd:cd17328  107 IAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVL-LAILLLLFVREPPRGAaeg 185

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 535035221 206 ---VSFSAKSVLRDFRNVFCNRQFL---FGAATIS 234
Cdd:cd17328  186 gvmAKSTATSFLADLKALAKNPSFIlstLGFTAVS 220
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 51-196 2.18e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.85  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  51 DFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATV 130
Cdd:cd17477   25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVV 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 535035221 131 GYVTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWkvLFAIIAIMGFISFVGLLLA 196
Cdd:cd17477  105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLLALVPLLLT 168
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
25-197 2.98e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  25 MALILYDFAAYLSTDLIQPGIINVVRD-FNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAA 103
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 104 TMF--TTSMTQFLIARAIQGTSICFIATVGYVTVQEA--FGQTK-GIRLMAIITSIVL----IAPIIGPLSGAALMHFVH 174
Cdd:COG2211  311 LFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdYDEWKtGRRREGLYFGIFTfaikLGQALAGALAGLLLALFG 390

                        170       180       190
                 ....*....|....*....|....*....|.
gi 535035221 175 WK--------VLFAIIAIMGFISFVGLLLAM 197
Cdd:COG2211  391 YVagaaqspsALTGIRLLFFLLPAVLLLLAA 421
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 40-121 3.37e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.54  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  40 LIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWL----LGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLI 115
Cdd:cd17388   17 LIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIfapiLGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96


                 ....*.
gi 535035221 116 ARAIQG 121
Cdd:cd17388   97 GRIIAG 102
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 62-127 4.47e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 38.94  E-value: 4.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 535035221  62 AVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFI 127
Cdd:cd17446   38 AQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGI 103
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 139-337 6.08e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 38.83  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  139 FGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVhwkVLFAIIAIMGFI-SFVGLLLAMPETVKRGAVSFSAKSVLRDF 217
Cdd:pfam13347 141 FFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFA---LIGAVLMLLGVIiTAAGTKERVSMRSKEDTGQKEAGSLLDML 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  218 RNVFCNRQFLFGAATISLSYIPMMSWVAVSPVIL---IDAGGLTTSQFAWTQVPVFGAVIVANAIVARFVKDPTeprFIW 294
Cdd:pfam13347 218 KEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFryvLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT---YIL 294

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 535035221  295 ravpIQLVGLALLIIGNLLSPHVWLWSVLGTSLYAFGIGLIFP 337
Cdd:pfam13347 295 ----GALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFF 333
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 7-115 6.61e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.43  E-value: 6.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221   7 KGLMAGLKATHAATLFFpmalilYDFAAYLSTDLIQpgiinvVRDFNADVSLAPAAVSLYLAggMALQWLLGPLSDRIGR 86
Cdd:cd17367  223 RELLLVVGLTAGGTLAF------YTWTTYLQKFLVN------TAGFSKGDATWITTAALLVF--MLLQPLGGRLSDRIGR 288

                         90       100       110
                 ....*....|....*....|....*....|...
gi 535035221  87 RPVLITGALIFTLACAATMF----TTSMTQFLI 115
Cdd:cd17367  289 RPLLLFFGIGGTLATVPLLSaldhTDSPYTAFA 321
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 27-196 9.39e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 37.98  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  27 LILYDFAAYLSTDLIQPGIINVVRDFNADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMF 106
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221 107 TTSMTQFLIARAIQG-----TSICFIATVGYVTVQEafgQTKGIRLMAIITSIVLiapIIGPLSGAalmHFVHWKVLFAI 181
Cdd:cd17390   81 STSLALLFLSRIPLGifkhtQSLCKAYLSDLVSEQE---RSRVLGRFNAASSLGF---ILGPVVGG---HLAETDGGFYY 151

                        170
                 ....*....|....*.
gi 535035221 182 IA-IMGFISFVGLLLA 196
Cdd:cd17390  152 VAlLCSAIFILNAGLV 167
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 55-195 9.54e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 37.97  E-value: 9.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 535035221  55 DVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITgALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGY-- 132
Cdd:cd17353  247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI-AFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALfp 325

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 535035221 133 VTVQEAFGQTKGIRLMAIITSIVLIAPIIGPLSGAALMHFVHWKVLFAIIAIMGFISFVGLLL 195
Cdd:cd17353  326 ALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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