oxidoreductase Fe-S subunit/nucleotide-binding subunit [Escherichia coli HVH 201 (4-4459431)]
Protein Classification
oxidoreductase FeS-binding subunit( domain architecture ID 11486207)
oxidoreductase FeS-binding subunit similar to Escherichia coli protein YgfT
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||
| PRK12809 | PRK12809 | putative oxidoreductase Fe-S binding subunit; Reviewed |
1-639 | 0e+00 | |||||||||
putative oxidoreductase Fe-S binding subunit; Reviewed : Pssm-ID: 183762 [Multi-domain] Cd Length: 639 Bit Score: 1336.59 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||||||
| PRK12809 | PRK12809 | putative oxidoreductase Fe-S binding subunit; Reviewed |
1-639 | 0e+00 | |||||||||
putative oxidoreductase Fe-S binding subunit; Reviewed Pssm-ID: 183762 [Multi-domain] Cd Length: 639 Bit Score: 1336.59 E-value: 0e+00
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| gltD_gamma_fam | TIGR01318 | glutamate synthase small subunit family protein, proteobacterial; This model represents one of ... |
169-636 | 0e+00 | |||||||||
glutamate synthase small subunit family protein, proteobacterial; This model represents one of three built for the NADPH-dependent or NADH-dependent glutamate synthase (EC 1.4.1.13 and 1.4.1.14, respectively) small subunit and homologs. TIGR01317 describes the small subunit (or equivalent region from longer forms) in eukaryotes, Gram-positive bacteria, and some other lineages, both NADH and NADPH-dependent. TIGR01316 describes a protein of similar length, from Archaea and a number of bacterial lineages, that forms glutamate synthase homotetramers without a large subunit. This model describes both glutatate synthase small subunit and closely related paralogs of unknown function from a number of gamma and alpha subdivision Proteobacteria, including E. coli. Pssm-ID: 273553 [Multi-domain] Cd Length: 467 Bit Score: 905.33 E-value: 0e+00
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| GltD | COG0493 | NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ... |
187-630 | 0e+00 | |||||||||
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis Pssm-ID: 440259 [Multi-domain] Cd Length: 434 Bit Score: 613.30 E-value: 0e+00
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| HycB_like | cd10554 | HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ... |
4-137 | 6.29e-60 | |||||||||
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation. Pssm-ID: 319876 [Multi-domain] Cd Length: 149 Bit Score: 197.10 E-value: 6.29e-60
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| Fer4_20 | pfam14691 | Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Domain II of the enzyme ... |
187-299 | 1.29e-51 | |||||||||
Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyzes the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds. This domain carries two Fe4-S4 clusters. Pssm-ID: 434132 [Multi-domain] Cd Length: 113 Bit Score: 173.49 E-value: 1.29e-51
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| ferrodoxin_EFR1 | NF038196 | EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ... |
86-133 | 5.86e-06 | |||||||||
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1). Pssm-ID: 468407 [Multi-domain] Cd Length: 243 Bit Score: 47.93 E-value: 5.86e-06
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| AlaDh_PNT_C | smart01002 | Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ... |
312-344 | 5.32e-05 | |||||||||
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine. Pssm-ID: 214966 [Multi-domain] Cd Length: 149 Bit Score: 43.65 E-value: 5.32e-05
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| Name | Accession | Description | Interval | E-value | ||||||||||
| PRK12809 | PRK12809 | putative oxidoreductase Fe-S binding subunit; Reviewed |
1-639 | 0e+00 | ||||||||||
putative oxidoreductase Fe-S binding subunit; Reviewed Pssm-ID: 183762 [Multi-domain] Cd Length: 639 Bit Score: 1336.59 E-value: 0e+00
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| PRK12769 | PRK12769 | putative oxidoreductase Fe-S binding subunit; Reviewed |
1-631 | 0e+00 | ||||||||||
putative oxidoreductase Fe-S binding subunit; Reviewed Pssm-ID: 183733 [Multi-domain] Cd Length: 654 Bit Score: 936.47 E-value: 0e+00
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| gltD_gamma_fam | TIGR01318 | glutamate synthase small subunit family protein, proteobacterial; This model represents one of ... |
169-636 | 0e+00 | ||||||||||
glutamate synthase small subunit family protein, proteobacterial; This model represents one of three built for the NADPH-dependent or NADH-dependent glutamate synthase (EC 1.4.1.13 and 1.4.1.14, respectively) small subunit and homologs. TIGR01317 describes the small subunit (or equivalent region from longer forms) in eukaryotes, Gram-positive bacteria, and some other lineages, both NADH and NADPH-dependent. TIGR01316 describes a protein of similar length, from Archaea and a number of bacterial lineages, that forms glutamate synthase homotetramers without a large subunit. This model describes both glutatate synthase small subunit and closely related paralogs of unknown function from a number of gamma and alpha subdivision Proteobacteria, including E. coli. Pssm-ID: 273553 [Multi-domain] Cd Length: 467 Bit Score: 905.33 E-value: 0e+00
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| gltD | PRK12810 | glutamate synthase subunit beta; Reviewed |
176-631 | 0e+00 | ||||||||||
glutamate synthase subunit beta; Reviewed Pssm-ID: 237213 [Multi-domain] Cd Length: 471 Bit Score: 626.42 E-value: 0e+00
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| GltD | COG0493 | NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ... |
187-630 | 0e+00 | ||||||||||
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis Pssm-ID: 440259 [Multi-domain] Cd Length: 434 Bit Score: 613.30 E-value: 0e+00
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| PRK11749 | PRK11749 | dihydropyrimidine dehydrogenase subunit A; Provisional |
179-630 | 0e+00 | ||||||||||
dihydropyrimidine dehydrogenase subunit A; Provisional Pssm-ID: 236967 [Multi-domain] Cd Length: 457 Bit Score: 539.00 E-value: 0e+00
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| PRK12831 | PRK12831 | putative oxidoreductase; Provisional |
183-629 | 8.36e-123 | ||||||||||
putative oxidoreductase; Provisional Pssm-ID: 183780 [Multi-domain] Cd Length: 464 Bit Score: 372.04 E-value: 8.36e-123
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| PRK12778 | PRK12778 | bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ... |
176-630 | 7.55e-116 | ||||||||||
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase; Pssm-ID: 237200 [Multi-domain] Cd Length: 752 Bit Score: 363.29 E-value: 7.55e-116
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| gltA | TIGR01316 | glutamate synthase (NADPH), homotetrameric; This protein is homologous to the small subunit of ... |
186-628 | 2.13e-110 | ||||||||||
glutamate synthase (NADPH), homotetrameric; This protein is homologous to the small subunit of NADPH and NADH forms of glutamate synthase as found in eukaryotes and some bacteria. This protein is found in numerous species having no homolog of the glutamate synthase large subunit. The prototype of the family, from Pyrococcus sp. KOD1, was shown to be active as a homotetramer and to require NADPH. [Amino acid biosynthesis, Glutamate family] Pssm-ID: 130383 [Multi-domain] Cd Length: 449 Bit Score: 339.54 E-value: 2.13e-110
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| PRK12771 | PRK12771 | putative glutamate synthase (NADPH) small subunit; Provisional |
219-630 | 4.62e-101 | ||||||||||
putative glutamate synthase (NADPH) small subunit; Provisional Pssm-ID: 237198 [Multi-domain] Cd Length: 564 Bit Score: 319.13 E-value: 4.62e-101
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| GOGAT_sm_gam | TIGR01317 | glutamate synthases, NADH/NADPH, small subunit; This model represents one of three built for ... |
187-628 | 1.01e-94 | ||||||||||
glutamate synthases, NADH/NADPH, small subunit; This model represents one of three built for the NADPH-dependent or NADH-dependent glutamate synthase (EC 1.4.1.13 and 1.4.1.14, respectively) small subunit or homologous region. TIGR01316 describes a family in several archaeal and deeply branched bacterial lineages of a homotetrameric form for which there is no large subunit. Another model describes glutamate synthase small subunit from gamma and some alpha subdivision Proteobacteria plus paralogs of unknown function. This model describes the small subunit, or homologous region of longer forms proteins, of eukaryotes, Gram-positive bacteria, cyanobacteria, and some other lineages. All members with known function participate in NADH or NADPH-dependent reactions to interconvert between glutamine plus 2-oxoglutarate and two molecules of glutamate. Pssm-ID: 162300 [Multi-domain] Cd Length: 485 Bit Score: 300.21 E-value: 1.01e-94
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| PRK12775 | PRK12775 | putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin ... |
98-632 | 3.56e-94 | ||||||||||
putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional Pssm-ID: 183738 [Multi-domain] Cd Length: 1006 Bit Score: 311.88 E-value: 3.56e-94
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| PRK12814 | PRK12814 | putative NADPH-dependent glutamate synthase small subunit; Provisional |
219-628 | 3.61e-84 | ||||||||||
putative NADPH-dependent glutamate synthase small subunit; Provisional Pssm-ID: 139246 [Multi-domain] Cd Length: 652 Bit Score: 277.38 E-value: 3.61e-84
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| PRK13984 | PRK13984 | putative oxidoreductase; Provisional |
83-628 | 5.25e-83 | ||||||||||
putative oxidoreductase; Provisional Pssm-ID: 172486 [Multi-domain] Cd Length: 604 Bit Score: 272.80 E-value: 5.25e-83
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| PRK12770 | PRK12770 | putative glutamate synthase subunit beta; Provisional |
308-630 | 3.44e-72 | ||||||||||
putative glutamate synthase subunit beta; Provisional Pssm-ID: 237197 [Multi-domain] Cd Length: 352 Bit Score: 236.81 E-value: 3.44e-72
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| PRK12779 | PRK12779 | putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; ... |
211-630 | 1.46e-67 | ||||||||||
putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional Pssm-ID: 183740 [Multi-domain] Cd Length: 944 Bit Score: 237.81 E-value: 1.46e-67
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| HycB_like | cd10554 | HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ... |
4-137 | 6.29e-60 | ||||||||||
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation. Pssm-ID: 319876 [Multi-domain] Cd Length: 149 Bit Score: 197.10 E-value: 6.29e-60
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| HycB | COG1142 | Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion]; |
1-139 | 1.71e-56 | ||||||||||
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion]; Pssm-ID: 440757 [Multi-domain] Cd Length: 138 Bit Score: 187.56 E-value: 1.71e-56
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| Fer4_20 | pfam14691 | Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Domain II of the enzyme ... |
187-299 | 1.29e-51 | ||||||||||
Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyzes the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds. This domain carries two Fe4-S4 clusters. Pssm-ID: 434132 [Multi-domain] Cd Length: 113 Bit Score: 173.49 E-value: 1.29e-51
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| PRK10330 | PRK10330 | electron transport protein HydN; |
1-160 | 1.57e-40 | ||||||||||
electron transport protein HydN; Pssm-ID: 182382 [Multi-domain] Cd Length: 181 Bit Score: 145.80 E-value: 1.57e-40
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| HybA | COG0437 | Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ... |
12-138 | 1.71e-36 | ||||||||||
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion]; Pssm-ID: 440206 [Multi-domain] Cd Length: 184 Bit Score: 134.69 E-value: 1.71e-36
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| DMSOR_beta_like | cd10550 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
5-136 | 4.59e-36 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319872 [Multi-domain] Cd Length: 130 Bit Score: 131.55 E-value: 4.59e-36
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| DMSOR_beta_like | cd16374 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-146 | 1.96e-35 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319896 [Multi-domain] Cd Length: 139 Bit Score: 130.47 E-value: 1.96e-35
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| CooF_like | cd10563 | CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ... |
12-134 | 5.25e-35 | ||||||||||
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction. Pssm-ID: 319885 [Multi-domain] Cd Length: 140 Bit Score: 129.30 E-value: 5.25e-35
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| DMSOR_beta-like | cd04410 | Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ... |
12-136 | 7.25e-33 | ||||||||||
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319870 [Multi-domain] Cd Length: 136 Bit Score: 122.88 E-value: 7.25e-33
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| PsrB | cd10551 | polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ... |
12-134 | 2.83e-32 | ||||||||||
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane. Pssm-ID: 319873 [Multi-domain] Cd Length: 185 Bit Score: 123.03 E-value: 2.83e-32
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| DMSOR_beta_like | cd16371 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-134 | 1.04e-30 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319893 [Multi-domain] Cd Length: 140 Bit Score: 116.89 E-value: 1.04e-30
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| DMSOR_beta_like | cd16369 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-144 | 4.91e-26 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319891 [Multi-domain] Cd Length: 172 Bit Score: 104.78 E-value: 4.91e-26
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| HybA_like | cd10561 | the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ... |
12-154 | 2.49e-25 | ||||||||||
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction. Pssm-ID: 319883 [Multi-domain] Cd Length: 196 Bit Score: 103.83 E-value: 2.49e-25
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| TrxB | COG0492 | Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; |
312-629 | 1.79e-24 | ||||||||||
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440258 [Multi-domain] Cd Length: 305 Bit Score: 104.05 E-value: 1.79e-24
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| DMSOR_beta_like | cd16367 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-138 | 9.22e-24 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319889 [Multi-domain] Cd Length: 138 Bit Score: 97.38 E-value: 9.22e-24
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| FDH_b_like | cd10562 | uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ... |
10-134 | 1.23e-21 | ||||||||||
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons. Pssm-ID: 319884 [Multi-domain] Cd Length: 161 Bit Score: 91.98 E-value: 1.23e-21
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| FDH_beta_like | cd16366 | beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ... |
12-134 | 4.01e-21 | ||||||||||
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate. Pssm-ID: 319888 [Multi-domain] Cd Length: 156 Bit Score: 90.15 E-value: 4.01e-21
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| FDH-O_like | cd10560 | beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ... |
12-163 | 1.04e-20 | ||||||||||
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N. Pssm-ID: 319882 [Multi-domain] Cd Length: 225 Bit Score: 91.29 E-value: 1.04e-20
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| TH_beta_N | cd10552 | N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ... |
10-138 | 3.52e-20 | ||||||||||
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2. Pssm-ID: 319874 [Multi-domain] Cd Length: 186 Bit Score: 88.54 E-value: 3.52e-20
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| FDH-N | cd10558 | The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ... |
8-151 | 3.81e-20 | ||||||||||
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. Pssm-ID: 319880 [Multi-domain] Cd Length: 208 Bit Score: 88.98 E-value: 3.81e-20
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| Pyr_redox_2 | pfam07992 | Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ... |
312-623 | 5.91e-20 | ||||||||||
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. Pssm-ID: 400379 [Multi-domain] Cd Length: 301 Bit Score: 90.84 E-value: 5.91e-20
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| DMSOR_beta_like | cd16372 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
3-138 | 1.30e-19 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319894 [Multi-domain] Cd Length: 125 Bit Score: 85.08 E-value: 1.30e-19
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| PhsB_like | cd10553 | uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ... |
12-136 | 1.72e-19 | ||||||||||
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319875 [Multi-domain] Cd Length: 146 Bit Score: 85.49 E-value: 1.72e-19
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| PLN02852 | PLN02852 | ferredoxin-NADP+ reductase |
304-468 | 3.04e-19 | ||||||||||
ferredoxin-NADP+ reductase Pssm-ID: 215457 Cd Length: 491 Bit Score: 91.30 E-value: 3.04e-19
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| PRK10882 | PRK10882 | hydrogenase 2 operon protein HybA; |
12-133 | 5.89e-19 | ||||||||||
hydrogenase 2 operon protein HybA; Pssm-ID: 236786 [Multi-domain] Cd Length: 328 Bit Score: 88.57 E-value: 5.89e-19
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| PRK09898 | PRK09898 | ferredoxin-like protein; |
7-138 | 4.63e-18 | ||||||||||
ferredoxin-like protein; Pssm-ID: 182135 [Multi-domain] Cd Length: 208 Bit Score: 82.96 E-value: 4.63e-18
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| PRK14993 | PRK14993 | tetrathionate reductase subunit TtrB; |
12-147 | 5.92e-16 | ||||||||||
tetrathionate reductase subunit TtrB; Pssm-ID: 184955 [Multi-domain] Cd Length: 244 Bit Score: 77.99 E-value: 5.92e-16
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| DMSOR_beta_like | cd16370 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-136 | 4.18e-15 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319892 [Multi-domain] Cd Length: 131 Bit Score: 72.31 E-value: 4.18e-15
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| CzcO | COG2072 | Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ... |
313-606 | 1.72e-13 | ||||||||||
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]; Pssm-ID: 441675 [Multi-domain] Cd Length: 414 Bit Score: 72.59 E-value: 1.72e-13
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| Fer4_11 | pfam13247 | 4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ... |
56-138 | 2.49e-13 | ||||||||||
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters. Pssm-ID: 404184 [Multi-domain] Cd Length: 99 Bit Score: 66.12 E-value: 2.49e-13
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| MtMvhB_like | cd10549 | Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ... |
52-140 | 3.35e-12 | ||||||||||
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction. Pssm-ID: 319871 [Multi-domain] Cd Length: 128 Bit Score: 63.96 E-value: 3.35e-12
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| MtMvhB_like | cd10549 | Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ... |
12-136 | 1.10e-11 | ||||||||||
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction. Pssm-ID: 319871 [Multi-domain] Cd Length: 128 Bit Score: 62.41 E-value: 1.10e-11
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| Nar1 | COG4624 | Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
12-100 | 2.73e-11 | ||||||||||
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 66.20 E-value: 2.73e-11
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| COG1233 | COG1233 | Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ... |
309-413 | 6.47e-11 | ||||||||||
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 440846 [Multi-domain] Cd Length: 491 Bit Score: 64.87 E-value: 6.47e-11
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| Ndh | COG1252 | NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; |
312-626 | 1.32e-10 | ||||||||||
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Pssm-ID: 440864 [Multi-domain] Cd Length: 386 Bit Score: 63.61 E-value: 1.32e-10
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| NarH_like | cd16365 | beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ... |
11-154 | 2.15e-10 | ||||||||||
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. Pssm-ID: 319887 [Multi-domain] Cd Length: 201 Bit Score: 60.67 E-value: 2.15e-10
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| COG2768 | COG2768 | Uncharacterized Fe-S cluster protein [Function unknown]; |
56-104 | 3.86e-10 | ||||||||||
Uncharacterized Fe-S cluster protein [Function unknown]; Pssm-ID: 442050 [Multi-domain] Cd Length: 74 Bit Score: 56.28 E-value: 3.86e-10
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| PRK07233 | PRK07233 | hypothetical protein; Provisional |
312-360 | 1.10e-09 | ||||||||||
hypothetical protein; Provisional Pssm-ID: 235977 [Multi-domain] Cd Length: 434 Bit Score: 61.06 E-value: 1.10e-09
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| FadH2 | COG0446 | NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ... |
334-631 | 1.43e-09 | ||||||||||
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]; Pssm-ID: 440215 [Multi-domain] Cd Length: 322 Bit Score: 59.82 E-value: 1.43e-09
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| EBDH_beta | cd10555 | beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ... |
30-130 | 1.77e-09 | ||||||||||
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration. Pssm-ID: 319877 [Multi-domain] Cd Length: 316 Bit Score: 59.62 E-value: 1.77e-09
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| Lpd | COG1249 | Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ... |
313-631 | 2.55e-09 | ||||||||||
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation Pssm-ID: 440861 [Multi-domain] Cd Length: 456 Bit Score: 59.72 E-value: 2.55e-09
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| Pyr_redox | pfam00070 | Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ... |
312-383 | 7.29e-09 | ||||||||||
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. Pssm-ID: 425450 [Multi-domain] Cd Length: 80 Bit Score: 52.98 E-value: 7.29e-09
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| FeFe_hydrog_B1 | TIGR04105 | [FeFe] hydrogenase, group B1/B3; See for descriptions of different groups. |
2-108 | 8.20e-09 | ||||||||||
[FeFe] hydrogenase, group B1/B3; See for descriptions of different groups. Pssm-ID: 274983 [Multi-domain] Cd Length: 462 Bit Score: 58.37 E-value: 8.20e-09
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| COG1149 | COG1149 | MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ... |
80-136 | 8.49e-09 | ||||||||||
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only]; Pssm-ID: 440763 [Multi-domain] Cd Length: 68 Bit Score: 52.42 E-value: 8.49e-09
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| DsrA | COG2221 | Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ... |
55-103 | 8.49e-09 | ||||||||||
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism]; Pssm-ID: 441823 [Multi-domain] Cd Length: 69 Bit Score: 52.36 E-value: 8.49e-09
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| MtMvhB_like | cd10549 | Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ... |
12-105 | 9.77e-09 | ||||||||||
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction. Pssm-ID: 319871 [Multi-domain] Cd Length: 128 Bit Score: 53.94 E-value: 9.77e-09
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| NAD_binding_8 | pfam13450 | NAD(P)-binding Rossmann-like domain; |
315-359 | 1.41e-08 | ||||||||||
NAD(P)-binding Rossmann-like domain; Pssm-ID: 433218 [Multi-domain] Cd Length: 67 Bit Score: 51.76 E-value: 1.41e-08
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| DMSOR_beta_like | cd16368 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
46-135 | 2.88e-08 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319890 [Multi-domain] Cd Length: 200 Bit Score: 54.35 E-value: 2.88e-08
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| COG3380 | COG3380 | Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; |
312-347 | 3.00e-08 | ||||||||||
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Pssm-ID: 442607 [Multi-domain] Cd Length: 331 Bit Score: 56.04 E-value: 3.00e-08
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| MtMvhB_like | cd10549 | Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ... |
82-146 | 3.67e-08 | ||||||||||
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction. Pssm-ID: 319871 [Multi-domain] Cd Length: 128 Bit Score: 52.40 E-value: 3.67e-08
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| Pyr_redox_2 | pfam07992 | Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ... |
286-404 | 3.68e-08 | ||||||||||
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. Pssm-ID: 400379 [Multi-domain] Cd Length: 301 Bit Score: 55.40 E-value: 3.68e-08
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| NapF | COG1145 | Ferredoxin [Energy production and conversion]; |
1-110 | 4.97e-08 | ||||||||||
Ferredoxin [Energy production and conversion]; Pssm-ID: 440760 [Multi-domain] Cd Length: 238 Bit Score: 54.34 E-value: 4.97e-08
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| Lpd | COG1249 | Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ... |
287-383 | 6.17e-08 | ||||||||||
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation Pssm-ID: 440861 [Multi-domain] Cd Length: 456 Bit Score: 55.48 E-value: 6.17e-08
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| HemY | COG1232 | Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ... |
312-349 | 7.18e-08 | ||||||||||
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis Pssm-ID: 440845 [Multi-domain] Cd Length: 443 Bit Score: 55.22 E-value: 7.18e-08
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| IorA | COG4231 | TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ... |
64-106 | 7.84e-08 | ||||||||||
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion]; Pssm-ID: 443375 [Multi-domain] Cd Length: 76 Bit Score: 49.66 E-value: 7.84e-08
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| W-FDH | cd10559 | tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ... |
10-163 | 7.94e-08 | ||||||||||
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons. Pssm-ID: 319881 [Multi-domain] Cd Length: 200 Bit Score: 53.21 E-value: 7.94e-08
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| COG2768 | COG2768 | Uncharacterized Fe-S cluster protein [Function unknown]; |
83-136 | 1.02e-07 | ||||||||||
Uncharacterized Fe-S cluster protein [Function unknown]; Pssm-ID: 442050 [Multi-domain] Cd Length: 74 Bit Score: 49.34 E-value: 1.02e-07
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| NapH | COG0348 | Polyferredoxin NapH [Energy production and conversion]; |
64-136 | 1.15e-07 | ||||||||||
Polyferredoxin NapH [Energy production and conversion]; Pssm-ID: 440117 [Multi-domain] Cd Length: 263 Bit Score: 53.53 E-value: 1.15e-07
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| NuoI | COG1143 | Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ... |
56-104 | 1.20e-07 | ||||||||||
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase Pssm-ID: 440758 [Multi-domain] Cd Length: 66 Bit Score: 48.97 E-value: 1.20e-07
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| COG1149 | COG1149 | MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ... |
52-106 | 1.23e-07 | ||||||||||
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only]; Pssm-ID: 440763 [Multi-domain] Cd Length: 68 Bit Score: 48.96 E-value: 1.23e-07
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| Nar1 | COG4624 | Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
56-139 | 1.34e-07 | ||||||||||
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 54.26 E-value: 1.34e-07
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| PRK08348 | PRK08348 | NADH-plastoquinone oxidoreductase subunit; Provisional |
83-139 | 1.42e-07 | ||||||||||
NADH-plastoquinone oxidoreductase subunit; Provisional Pssm-ID: 181399 [Multi-domain] Cd Length: 120 Bit Score: 50.60 E-value: 1.42e-07
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| PRK07208 | PRK07208 | hypothetical protein; Provisional |
308-348 | 1.52e-07 | ||||||||||
hypothetical protein; Provisional Pssm-ID: 235967 [Multi-domain] Cd Length: 479 Bit Score: 54.12 E-value: 1.52e-07
|
||||||||||||||
| NapF | COG1145 | Ferredoxin [Energy production and conversion]; |
83-140 | 1.53e-07 | ||||||||||
Ferredoxin [Energy production and conversion]; Pssm-ID: 440760 [Multi-domain] Cd Length: 238 Bit Score: 52.80 E-value: 1.53e-07
|
||||||||||||||
| PRK07118 | PRK07118 | Fe-S cluster domain-containing protein; |
64-155 | 2.00e-07 | ||||||||||
Fe-S cluster domain-containing protein; Pssm-ID: 235941 [Multi-domain] Cd Length: 280 Bit Score: 53.01 E-value: 2.00e-07
|
||||||||||||||
| SER_beta | cd10556 | Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ... |
53-137 | 2.05e-07 | ||||||||||
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier. Pssm-ID: 319878 [Multi-domain] Cd Length: 287 Bit Score: 52.85 E-value: 2.05e-07
|
||||||||||||||
| Fer4_7 | pfam12838 | 4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ... |
56-101 | 2.08e-07 | ||||||||||
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters. Pssm-ID: 463724 [Multi-domain] Cd Length: 51 Bit Score: 47.91 E-value: 2.08e-07
|
||||||||||||||
| PRK07118 | PRK07118 | Fe-S cluster domain-containing protein; |
64-139 | 2.67e-07 | ||||||||||
Fe-S cluster domain-containing protein; Pssm-ID: 235941 [Multi-domain] Cd Length: 280 Bit Score: 52.63 E-value: 2.67e-07
|
||||||||||||||
| PorD | COG1144 | Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ... |
56-106 | 3.31e-07 | ||||||||||
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation Pssm-ID: 440759 [Multi-domain] Cd Length: 84 Bit Score: 48.12 E-value: 3.31e-07
|
||||||||||||||
| NuoI | COG1143 | Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ... |
84-136 | 5.75e-07 | ||||||||||
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase Pssm-ID: 440758 [Multi-domain] Cd Length: 66 Bit Score: 47.05 E-value: 5.75e-07
|
||||||||||||||
| PorD | COG1144 | Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ... |
82-140 | 6.14e-07 | ||||||||||
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation Pssm-ID: 440759 [Multi-domain] Cd Length: 84 Bit Score: 47.35 E-value: 6.14e-07
|
||||||||||||||
| PreA | COG1146 | NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ... |
80-144 | 8.78e-07 | ||||||||||
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism]; Pssm-ID: 440761 [Multi-domain] Cd Length: 67 Bit Score: 46.63 E-value: 8.78e-07
|
||||||||||||||
| DsrA | COG2221 | Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ... |
80-135 | 9.16e-07 | ||||||||||
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism]; Pssm-ID: 441823 [Multi-domain] Cd Length: 69 Bit Score: 46.58 E-value: 9.16e-07
|
||||||||||||||
| YhiN | COG2081 | Predicted flavoprotein YhiN [General function prediction only]; |
314-346 | 9.76e-07 | ||||||||||
Predicted flavoprotein YhiN [General function prediction only]; Pssm-ID: 441684 [Multi-domain] Cd Length: 402 Bit Score: 51.59 E-value: 9.76e-07
|
||||||||||||||
| NapF_like | cd10564 | NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ... |
8-104 | 1.18e-06 | ||||||||||
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319886 [Multi-domain] Cd Length: 139 Bit Score: 48.39 E-value: 1.18e-06
|
||||||||||||||
| PTZ00188 | PTZ00188 | adrenodoxin reductase; Provisional |
312-404 | 1.38e-06 | ||||||||||
adrenodoxin reductase; Provisional Pssm-ID: 240308 Cd Length: 506 Bit Score: 51.42 E-value: 1.38e-06
|
||||||||||||||
| COG3349 | COG3349 | Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ... |
312-347 | 1.46e-06 | ||||||||||
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only]; Pssm-ID: 442577 [Multi-domain] Cd Length: 445 Bit Score: 51.01 E-value: 1.46e-06
|
||||||||||||||
| FadH2 | COG0446 | NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ... |
311-404 | 2.68e-06 | ||||||||||
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]; Pssm-ID: 440215 [Multi-domain] Cd Length: 322 Bit Score: 49.81 E-value: 2.68e-06
|
||||||||||||||
| HI0933_like | pfam03486 | HI0933-like protein; |
312-346 | 3.13e-06 | ||||||||||
HI0933-like protein; Pssm-ID: 427330 [Multi-domain] Cd Length: 406 Bit Score: 49.89 E-value: 3.13e-06
|
||||||||||||||
| YobN | COG1231 | Monoamine oxidase [Amino acid transport and metabolism]; |
308-347 | 4.36e-06 | ||||||||||
Monoamine oxidase [Amino acid transport and metabolism]; Pssm-ID: 440844 [Multi-domain] Cd Length: 440 Bit Score: 49.53 E-value: 4.36e-06
|
||||||||||||||
| HdrA | COG1148 | Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion]; |
81-148 | 5.73e-06 | ||||||||||
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion]; Pssm-ID: 440762 [Multi-domain] Cd Length: 563 Bit Score: 49.47 E-value: 5.73e-06
|
||||||||||||||
| ferrodoxin_EFR1 | NF038196 | EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ... |
86-133 | 5.86e-06 | ||||||||||
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1). Pssm-ID: 468407 [Multi-domain] Cd Length: 243 Bit Score: 47.93 E-value: 5.86e-06
|
||||||||||||||
| UbiH | COG0654 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ... |
312-375 | 6.63e-06 | ||||||||||
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis Pssm-ID: 440419 [Multi-domain] Cd Length: 326 Bit Score: 48.40 E-value: 6.63e-06
|
||||||||||||||
| HdrA | COG1148 | Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion]; |
300-627 | 9.45e-06 | ||||||||||
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion]; Pssm-ID: 440762 [Multi-domain] Cd Length: 563 Bit Score: 48.70 E-value: 9.45e-06
|
||||||||||||||
| PreA | COG1146 | NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ... |
52-106 | 9.70e-06 | ||||||||||
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism]; Pssm-ID: 440761 [Multi-domain] Cd Length: 67 Bit Score: 43.54 E-value: 9.70e-06
|
||||||||||||||
| NarH_beta-like | cd10557 | beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ... |
53-129 | 1.44e-05 | ||||||||||
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli. Pssm-ID: 319879 [Multi-domain] Cd Length: 363 Bit Score: 47.74 E-value: 1.44e-05
|
||||||||||||||
| PRK06292 | PRK06292 | dihydrolipoamide dehydrogenase; Validated |
313-629 | 1.69e-05 | ||||||||||
dihydrolipoamide dehydrogenase; Validated Pssm-ID: 235774 [Multi-domain] Cd Length: 460 Bit Score: 47.86 E-value: 1.69e-05
|
||||||||||||||
| DAO | pfam01266 | FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ... |
312-379 | 1.87e-05 | ||||||||||
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1. Pssm-ID: 426168 [Multi-domain] Cd Length: 339 Bit Score: 47.39 E-value: 1.87e-05
|
||||||||||||||
| COG2509 | COG2509 | FAD-dependent dehydrogenase [General function prediction only]; |
305-341 | 2.19e-05 | ||||||||||
FAD-dependent dehydrogenase [General function prediction only]; Pssm-ID: 441999 [Multi-domain] Cd Length: 466 Bit Score: 47.41 E-value: 2.19e-05
|
||||||||||||||
| PRK12387 | PRK12387 | formate hydrogenlyase complex iron-sulfur subunit; Provisional |
52-129 | 3.60e-05 | ||||||||||
formate hydrogenlyase complex iron-sulfur subunit; Provisional Pssm-ID: 183492 [Multi-domain] Cd Length: 180 Bit Score: 44.64 E-value: 3.60e-05
|
||||||||||||||
| DMSOR_beta_like | cd16373 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
85-149 | 5.02e-05 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319895 [Multi-domain] Cd Length: 154 Bit Score: 43.78 E-value: 5.02e-05
|
||||||||||||||
| PRK12771 | PRK12771 | putative glutamate synthase (NADPH) small subunit; Provisional |
182-224 | 5.11e-05 | ||||||||||
putative glutamate synthase (NADPH) small subunit; Provisional Pssm-ID: 237198 [Multi-domain] Cd Length: 564 Bit Score: 46.41 E-value: 5.11e-05
|
||||||||||||||
| AlaDh_PNT_C | smart01002 | Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ... |
312-344 | 5.32e-05 | ||||||||||
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine. Pssm-ID: 214966 [Multi-domain] Cd Length: 149 Bit Score: 43.65 E-value: 5.32e-05
|
||||||||||||||
| PRK09126 | PRK09126 | FAD-dependent hydroxylase; |
313-344 | 5.46e-05 | ||||||||||
FAD-dependent hydroxylase; Pssm-ID: 236385 [Multi-domain] Cd Length: 392 Bit Score: 46.09 E-value: 5.46e-05
|
||||||||||||||
| PRK06292 | PRK06292 | dihydrolipoamide dehydrogenase; Validated |
288-404 | 5.49e-05 | ||||||||||
dihydrolipoamide dehydrogenase; Validated Pssm-ID: 235774 [Multi-domain] Cd Length: 460 Bit Score: 45.94 E-value: 5.49e-05
|
||||||||||||||
| NapF_like | cd10564 | NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ... |
55-135 | 6.12e-05 | ||||||||||
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319886 [Multi-domain] Cd Length: 139 Bit Score: 43.39 E-value: 6.12e-05
|
||||||||||||||
| PRK05249 | PRK05249 | Si-specific NAD(P)(+) transhydrogenase; |
315-631 | 7.05e-05 | ||||||||||
Si-specific NAD(P)(+) transhydrogenase; Pssm-ID: 235373 [Multi-domain] Cd Length: 461 Bit Score: 45.53 E-value: 7.05e-05
|
||||||||||||||
| PLN02172 | PLN02172 | flavin-containing monooxygenase FMO GS-OX |
310-361 | 8.31e-05 | ||||||||||
flavin-containing monooxygenase FMO GS-OX Pssm-ID: 215116 [Multi-domain] Cd Length: 461 Bit Score: 45.62 E-value: 8.31e-05
|
||||||||||||||
| FAD_binding_3 | pfam01494 | FAD binding domain; This domain is involved in FAD binding in a number of enzymes. |
312-344 | 9.41e-05 | ||||||||||
FAD binding domain; This domain is involved in FAD binding in a number of enzymes. Pssm-ID: 396193 [Multi-domain] Cd Length: 348 Bit Score: 45.01 E-value: 9.41e-05
|
||||||||||||||
| PRK12387 | PRK12387 | formate hydrogenlyase complex iron-sulfur subunit; Provisional |
85-139 | 1.02e-04 | ||||||||||
formate hydrogenlyase complex iron-sulfur subunit; Provisional Pssm-ID: 183492 [Multi-domain] Cd Length: 180 Bit Score: 43.48 E-value: 1.02e-04
|
||||||||||||||
| FAD_oxidored | pfam12831 | FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ... |
313-352 | 1.03e-04 | ||||||||||
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins. Pssm-ID: 432816 [Multi-domain] Cd Length: 420 Bit Score: 45.29 E-value: 1.03e-04
|
||||||||||||||
| Fer4_7 | pfam12838 | 4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ... |
87-133 | 1.10e-04 | ||||||||||
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters. Pssm-ID: 463724 [Multi-domain] Cd Length: 51 Bit Score: 40.20 E-value: 1.10e-04
|
||||||||||||||
| RnfB | COG2878 | Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ... |
83-137 | 1.15e-04 | ||||||||||
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase Pssm-ID: 442125 [Multi-domain] Cd Length: 254 Bit Score: 44.21 E-value: 1.15e-04
|
||||||||||||||
| PRK06370 | PRK06370 | FAD-containing oxidoreductase; |
288-383 | 1.21e-04 | ||||||||||
FAD-containing oxidoreductase; Pssm-ID: 235787 [Multi-domain] Cd Length: 463 Bit Score: 44.81 E-value: 1.21e-04
|
||||||||||||||
| Fer4_9 | pfam13187 | 4Fe-4S dicluster domain; |
86-134 | 1.26e-04 | ||||||||||
4Fe-4S dicluster domain; Pssm-ID: 463801 [Multi-domain] Cd Length: 50 Bit Score: 39.84 E-value: 1.26e-04
|
||||||||||||||
| PRK13795 | PRK13795 | hypothetical protein; Provisional |
64-98 | 1.35e-04 | ||||||||||
hypothetical protein; Provisional Pssm-ID: 237510 [Multi-domain] Cd Length: 636 Bit Score: 44.99 E-value: 1.35e-04
|
||||||||||||||
| TIGR00275 | TIGR00275 | flavoprotein, HI0933 family; The model when searched with a partial length search brings in ... |
314-346 | 1.37e-04 | ||||||||||
flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 272992 [Multi-domain] Cd Length: 400 Bit Score: 44.51 E-value: 1.37e-04
|
||||||||||||||
| mhpA | PRK06183 | bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase; |
313-345 | 1.81e-04 | ||||||||||
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase; Pssm-ID: 235727 [Multi-domain] Cd Length: 500 Bit Score: 44.51 E-value: 1.81e-04
|
||||||||||||||
| DadA | COG0665 | Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]; |
312-379 | 1.90e-04 | ||||||||||
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]; Pssm-ID: 440429 [Multi-domain] Cd Length: 364 Bit Score: 44.13 E-value: 1.90e-04
|
||||||||||||||
| flavo_MJ0208 | TIGR02700 | archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ... |
56-102 | 2.37e-04 | ||||||||||
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General] Pssm-ID: 131747 [Multi-domain] Cd Length: 234 Bit Score: 42.94 E-value: 2.37e-04
|
||||||||||||||
| FixX | COG2440 | Ferredoxin-like protein FixX [Energy production and conversion]; |
35-103 | 2.54e-04 | ||||||||||
Ferredoxin-like protein FixX [Energy production and conversion]; Pssm-ID: 441981 [Multi-domain] Cd Length: 87 Bit Score: 40.19 E-value: 2.54e-04
|
||||||||||||||
| RnfB | COG2878 | Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ... |
64-105 | 2.73e-04 | ||||||||||
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase Pssm-ID: 442125 [Multi-domain] Cd Length: 254 Bit Score: 43.06 E-value: 2.73e-04
|
||||||||||||||
| Ppro0129 | COG2907 | Predicted flavin-containing amine oxidase [General function prediction only]; |
309-347 | 2.80e-04 | ||||||||||
Predicted flavin-containing amine oxidase [General function prediction only]; Pssm-ID: 442151 [Multi-domain] Cd Length: 423 Bit Score: 43.57 E-value: 2.80e-04
|
||||||||||||||
| mnmC | PRK01747 | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ... |
308-346 | 3.02e-04 | ||||||||||
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC; Pssm-ID: 234978 [Multi-domain] Cd Length: 662 Bit Score: 44.07 E-value: 3.02e-04
|
||||||||||||||
| PRK06116 | PRK06116 | glutathione reductase; Validated |
452-637 | 3.25e-04 | ||||||||||
glutathione reductase; Validated Pssm-ID: 235701 [Multi-domain] Cd Length: 450 Bit Score: 43.61 E-value: 3.25e-04
|
||||||||||||||
| PRK06273 | PRK06273 | ferredoxin; Provisional |
83-134 | 3.63e-04 | ||||||||||
ferredoxin; Provisional Pssm-ID: 235764 [Multi-domain] Cd Length: 165 Bit Score: 41.62 E-value: 3.63e-04
|
||||||||||||||
| PLN00093 | PLN00093 | geranylgeranyl diphosphate reductase; Provisional |
301-362 | 3.66e-04 | ||||||||||
geranylgeranyl diphosphate reductase; Provisional Pssm-ID: 177713 [Multi-domain] Cd Length: 450 Bit Score: 43.59 E-value: 3.66e-04
|
||||||||||||||
| PRK10194 | PRK10194 | ferredoxin-type protein NapF; |
11-102 | 3.74e-04 | ||||||||||
ferredoxin-type protein NapF; Pssm-ID: 182296 [Multi-domain] Cd Length: 163 Bit Score: 41.55 E-value: 3.74e-04
|
||||||||||||||
| DMSOR_beta_like | cd16373 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-131 | 4.26e-04 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319895 [Multi-domain] Cd Length: 154 Bit Score: 41.09 E-value: 4.26e-04
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| DMSOR_beta_like | cd16371 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
12-75 | 4.69e-04 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319893 [Multi-domain] Cd Length: 140 Bit Score: 40.62 E-value: 4.69e-04
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| PRK06185 | PRK06185 | FAD-dependent oxidoreductase; |
313-343 | 4.72e-04 | ||||||||||
FAD-dependent oxidoreductase; Pssm-ID: 235729 [Multi-domain] Cd Length: 407 Bit Score: 42.92 E-value: 4.72e-04
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| PRK07118 | PRK07118 | Fe-S cluster domain-containing protein; |
12-111 | 5.19e-04 | ||||||||||
Fe-S cluster domain-containing protein; Pssm-ID: 235941 [Multi-domain] Cd Length: 280 Bit Score: 42.23 E-value: 5.19e-04
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| rnfB | TIGR01944 | electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ... |
82-136 | 6.07e-04 | ||||||||||
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport] Pssm-ID: 273887 [Multi-domain] Cd Length: 165 Bit Score: 40.94 E-value: 6.07e-04
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| Ala_dh_like | cd01620 | Alanine dehydrogenase and related dehydrogenases; Alanine dehydrogenase/Transhydrogenase, such ... |
301-373 | 6.89e-04 | ||||||||||
Alanine dehydrogenase and related dehydrogenases; Alanine dehydrogenase/Transhydrogenase, such as the hexameric L-alanine dehydrogenase of Phormidium lapideum, contain 2 Rossmann fold-like domains linked by an alpha helical region. Related proteins include Saccharopine Dehydrogenase (SDH), bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme, N(5)-(carboxyethyl)ornithine synthase, and Rubrum transdehydrogenase. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyrucate to L-alanine via reductive amination. Transhydrogenases found in bacterial and inner mitochondrial membranes link NAD(P)(H)-dependent redox reactions to proton translocation. The energy of the proton electrochemical gradient (delta-p), generated by the respiratory electron transport chain, is consumed by transhydrogenase in NAD(P)+ reduction. Transhydrogenase is likely involved in the regulation of the citric acid cycle. Rubrum transhydrogenase has 3 components, dI, dII, and dIII. dII spans the membrane while dI and dIII protrude on the cytoplasmic/matirx side. DI contains 2 domains with Rossmann folds, linked by a long alpha helix, and contains a NAD binding site. Two dI polypeptides (represented in this sub-family) spontaneously form a heterotrimer with one dIII in the absence of dII. In the heterotrimer, both dI chains may bind NAD, but only one is well-ordered. dIII also binds a well-ordered NADP, but in a different orientation than classical Rossmann domains. Pssm-ID: 240621 [Multi-domain] Cd Length: 317 Bit Score: 42.01 E-value: 6.89e-04
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| PRK06753 | PRK06753 | hypothetical protein; Provisional |
312-345 | 7.17e-04 | ||||||||||
hypothetical protein; Provisional Pssm-ID: 168661 [Multi-domain] Cd Length: 373 Bit Score: 42.37 E-value: 7.17e-04
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| DMSOR_beta-like | cd04410 | Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ... |
82-134 | 7.39e-04 | ||||||||||
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319870 [Multi-domain] Cd Length: 136 Bit Score: 40.07 E-value: 7.39e-04
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| PRK08222 | PRK08222 | hydrogenase 4 subunit H; Validated |
52-114 | 7.51e-04 | ||||||||||
hydrogenase 4 subunit H; Validated Pssm-ID: 181301 [Multi-domain] Cd Length: 181 Bit Score: 40.89 E-value: 7.51e-04
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| Thi4 | pfam01946 | Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme. |
313-347 | 7.60e-04 | ||||||||||
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme. Pssm-ID: 460393 Cd Length: 232 Bit Score: 41.69 E-value: 7.60e-04
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| 3HCDH_N | pfam02737 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ... |
312-345 | 7.91e-04 | ||||||||||
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin. Pssm-ID: 397037 [Multi-domain] Cd Length: 180 Bit Score: 40.98 E-value: 7.91e-04
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| Fer4_21 | pfam14697 | 4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ... |
83-131 | 1.11e-03 | ||||||||||
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters. Pssm-ID: 434137 [Multi-domain] Cd Length: 59 Bit Score: 37.65 E-value: 1.11e-03
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| Pyr_redox | pfam00070 | Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ... |
453-524 | 1.20e-03 | ||||||||||
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. Pssm-ID: 425450 [Multi-domain] Cd Length: 80 Bit Score: 37.95 E-value: 1.20e-03
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| Fer4_10 | pfam13237 | 4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ... |
80-130 | 1.28e-03 | ||||||||||
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich. Pssm-ID: 404174 [Multi-domain] Cd Length: 56 Bit Score: 37.23 E-value: 1.28e-03
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| PLN02487 | PLN02487 | zeta-carotene desaturase |
312-347 | 1.29e-03 | ||||||||||
zeta-carotene desaturase Pssm-ID: 215268 [Multi-domain] Cd Length: 569 Bit Score: 41.71 E-value: 1.29e-03
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| PRK08222 | PRK08222 | hydrogenase 4 subunit H; Validated |
81-139 | 1.36e-03 | ||||||||||
hydrogenase 4 subunit H; Validated Pssm-ID: 181301 [Multi-domain] Cd Length: 181 Bit Score: 40.12 E-value: 1.36e-03
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| carotene-cycl | TIGR01790 | lycopene cyclase family protein; This family includes lycopene beta and epsilion cyclases ... |
313-353 | 1.37e-03 | ||||||||||
lycopene cyclase family protein; This family includes lycopene beta and epsilion cyclases (which form beta and delta carotene, respectively) from bacteria and plants as well as the plant capsanthin/capsorubin and neoxanthin cyclases which appear to have evolved from the plant lycopene cyclases. The plant lycopene epsilon cyclases also transform neurosporene to alpha zeacarotene. Pssm-ID: 130850 [Multi-domain] Cd Length: 388 Bit Score: 41.65 E-value: 1.37e-03
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| YdhS | COG4529 | Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only]; |
308-348 | 1.45e-03 | ||||||||||
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only]; Pssm-ID: 443597 [Multi-domain] Cd Length: 466 Bit Score: 41.48 E-value: 1.45e-03
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| Fer4_7 | pfam12838 | 4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ... |
12-72 | 1.67e-03 | ||||||||||
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters. Pssm-ID: 463724 [Multi-domain] Cd Length: 51 Bit Score: 36.74 E-value: 1.67e-03
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| NapF_like | cd10564 | NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ... |
10-136 | 1.73e-03 | ||||||||||
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319886 [Multi-domain] Cd Length: 139 Bit Score: 39.15 E-value: 1.73e-03
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| NuoI | TIGR01971 | NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ... |
84-136 | 1.74e-03 | ||||||||||
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport] Pssm-ID: 273902 [Multi-domain] Cd Length: 122 Bit Score: 38.94 E-value: 1.74e-03
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| Zn_ADH7 | cd08261 | Alcohol dehydrogenases of the MDR family; This group contains members identified as related to ... |
311-344 | 1.93e-03 | ||||||||||
Alcohol dehydrogenases of the MDR family; This group contains members identified as related to zinc-dependent alcohol dehydrogenase and other members of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group includes various activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines. Pssm-ID: 176222 [Multi-domain] Cd Length: 337 Bit Score: 41.02 E-value: 1.93e-03
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| PRK12409 | PRK12409 | D-amino acid dehydrogenase small subunit; Provisional |
312-342 | 1.95e-03 | ||||||||||
D-amino acid dehydrogenase small subunit; Provisional Pssm-ID: 237093 [Multi-domain] Cd Length: 410 Bit Score: 41.16 E-value: 1.95e-03
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| Fer4 | pfam00037 | 4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ... |
80-103 | 2.06e-03 | ||||||||||
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Pssm-ID: 459642 [Multi-domain] Cd Length: 24 Bit Score: 35.69 E-value: 2.06e-03
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| Tdh | COG1063 | Threonine dehydrogenase or related Zn-dependent dehydrogenase [Amino acid transport and ... |
311-380 | 2.27e-03 | ||||||||||
Threonine dehydrogenase or related Zn-dependent dehydrogenase [Amino acid transport and metabolism, General function prediction only]; Threonine dehydrogenase or related Zn-dependent dehydrogenase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway Pssm-ID: 440683 [Multi-domain] Cd Length: 341 Bit Score: 40.51 E-value: 2.27e-03
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| PRK07251 | PRK07251 | FAD-containing oxidoreductase; |
311-404 | 2.39e-03 | ||||||||||
FAD-containing oxidoreductase; Pssm-ID: 180907 [Multi-domain] Cd Length: 438 Bit Score: 40.89 E-value: 2.39e-03
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| DMSOR_beta_like | cd16374 | uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ... |
80-135 | 2.52e-03 | ||||||||||
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Pssm-ID: 319896 [Multi-domain] Cd Length: 139 Bit Score: 38.80 E-value: 2.52e-03
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| napG | PRK09476 | quinol dehydrogenase periplasmic component; Provisional |
2-99 | 2.82e-03 | ||||||||||
quinol dehydrogenase periplasmic component; Provisional Pssm-ID: 236534 [Multi-domain] Cd Length: 254 Bit Score: 39.99 E-value: 2.82e-03
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| FadB | COG1250 | 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ... |
311-344 | 2.90e-03 | ||||||||||
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis Pssm-ID: 440862 [Multi-domain] Cd Length: 281 Bit Score: 40.09 E-value: 2.90e-03
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| PRK08132 | PRK08132 | FAD-dependent oxidoreductase; Provisional |
300-346 | 2.96e-03 | ||||||||||
FAD-dependent oxidoreductase; Provisional Pssm-ID: 236158 [Multi-domain] Cd Length: 547 Bit Score: 40.62 E-value: 2.96e-03
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| SIMIBI_bact_arch | cd03110 | bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ... |
81-138 | 3.26e-03 | ||||||||||
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown. Pssm-ID: 349764 [Multi-domain] Cd Length: 246 Bit Score: 39.68 E-value: 3.26e-03
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| GG-red-SF | TIGR02032 | geranylgeranyl reductase family; This model represents a subfamily which includes ... |
313-346 | 3.73e-03 | ||||||||||
geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll] Pssm-ID: 273936 [Multi-domain] Cd Length: 295 Bit Score: 39.61 E-value: 3.73e-03
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| PRK12771 | PRK12771 | putative glutamate synthase (NADPH) small subunit; Provisional |
56-105 | 4.23e-03 | ||||||||||
putative glutamate synthase (NADPH) small subunit; Provisional Pssm-ID: 237198 [Multi-domain] Cd Length: 564 Bit Score: 40.24 E-value: 4.23e-03
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| Nar1 | COG4624 | Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
2-82 | 4.91e-03 | ||||||||||
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 39.62 E-value: 4.91e-03
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| Fer4_6 | pfam12837 | 4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ... |
83-101 | 4.94e-03 | ||||||||||
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Pssm-ID: 432822 [Multi-domain] Cd Length: 24 Bit Score: 34.90 E-value: 4.94e-03
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| PLN02976 | PLN02976 | amine oxidase |
312-347 | 5.15e-03 | ||||||||||
amine oxidase Pssm-ID: 215527 [Multi-domain] Cd Length: 1713 Bit Score: 40.24 E-value: 5.15e-03
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| MDR | cd05188 | Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; ... |
293-344 | 5.32e-03 | ||||||||||
Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; The medium chain reductase/dehydrogenases (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH) , quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines. Other MDR members have only a catalytic zinc, and some contain no coordinated zinc. Pssm-ID: 176178 [Multi-domain] Cd Length: 271 Bit Score: 39.23 E-value: 5.32e-03
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| PRK08243 | PRK08243 | 4-hydroxybenzoate 3-monooxygenase; Validated |
312-341 | 6.19e-03 | ||||||||||
4-hydroxybenzoate 3-monooxygenase; Validated Pssm-ID: 236198 [Multi-domain] Cd Length: 392 Bit Score: 39.40 E-value: 6.19e-03
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| Malic_M | smart00919 | Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ... |
312-342 | 6.39e-03 | ||||||||||
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate. Pssm-ID: 214912 Cd Length: 231 Bit Score: 38.55 E-value: 6.39e-03
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| MurD | COG0771 | UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
312-344 | 6.87e-03 | ||||||||||
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 39.29 E-value: 6.87e-03
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| FixC | COG0644 | Dehydrogenase (flavoprotein) [Energy production and conversion]; |
318-346 | 7.12e-03 | ||||||||||
Dehydrogenase (flavoprotein) [Energy production and conversion]; Pssm-ID: 440409 [Multi-domain] Cd Length: 281 Bit Score: 38.80 E-value: 7.12e-03
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| Fer4_10 | pfam13237 | 4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ... |
52-98 | 8.15e-03 | ||||||||||
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich. Pssm-ID: 404174 [Multi-domain] Cd Length: 56 Bit Score: 34.92 E-value: 8.15e-03
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| PRK05113 | PRK05113 | electron transport complex protein RnfB; Provisional |
83-132 | 8.34e-03 | ||||||||||
electron transport complex protein RnfB; Provisional Pssm-ID: 235347 [Multi-domain] Cd Length: 191 Bit Score: 38.00 E-value: 8.34e-03
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| PRK13409 | PRK13409 | ribosome biogenesis/translation initiation ATPase RLI; |
41-105 | 8.50e-03 | ||||||||||
ribosome biogenesis/translation initiation ATPase RLI; Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 39.02 E-value: 8.50e-03
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| Zn_ADH8 | cd08262 | Alcohol dehydrogenases of the MDR family; The medium chain dehydrogenases/reductase (MDR) ... |
294-425 | 9.64e-03 | ||||||||||
Alcohol dehydrogenases of the MDR family; The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines. Pssm-ID: 176223 [Multi-domain] Cd Length: 341 Bit Score: 38.83 E-value: 9.64e-03
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| HdrA | COG1148 | Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion]; |
52-104 | 9.93e-03 | ||||||||||
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion]; Pssm-ID: 440762 [Multi-domain] Cd Length: 563 Bit Score: 39.07 E-value: 9.93e-03
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