|
Name |
Accession |
Description |
Interval |
E-value |
| alt_ValS |
NF000540 |
valine--tRNA ligase; |
2-856 |
0e+00 |
|
valine--tRNA ligase;
Pssm-ID: 467949 [Multi-domain] Cd Length: 827 Bit Score: 1613.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 2 PDRAVPEGLEHKWGSAWEAEGTYAFDRTAAREQVYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWD 81
Cdd:NF000540 1 PEKPSLDGLEAKWAARWEEDGTYAFDRPAAREEVFSIDTPPPTVSGSLHVGHVFSYTHTDVVARYQRMRGKEVFYPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 82 DNGLPTERRVQNYFGVRVDATLPYDPDFEPPHVGGegksikARDQKPISRRNFVELCERLTVEDEAQFEALWRYLGLSVD 161
Cdd:NF000540 81 DNGLPTERRVQNYYGVRCDPSLPYDPDFTPPEKPG------PKDQVPISRRNFIELCERLTAEDEKAFEDLWRRLGLSVD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 162 WKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREYPGFYHRIAFHLtdasaaaeaarag 241
Cdd:NF000540 155 WSLTYRTIGDRARRVSQRAFLRNLARGEAYQAEAPTLWDVTFQTAVAQAELEDREYPGAYHRLAFHG------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 242 apvEDGADVCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPAAEKDKGAGIAMCCTFGDTTDID 321
Cdd:NF000540 222 ---ADGGPVHIETTRPELLPACVALVAHPDDERYQPLFGTTVTSPLFGVEVPVLAHPLAEPDKGSGIAMCCTFGDLTDVT 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 322 WWRDLGLPLRAILRKDGRIVADTPEWITTEAGRTAFAEISGKTTFSAREAVVARLRGSGELKGEPTKTVRQTNFFEKGDK 401
Cdd:NF000540 299 WWRELQLPTRAIIGRDGRLLAETPEWITSEAGRAAYAELAGKTVFSAREAVVELLRESGDLDGEPRPIQHPVKFYEKGDK 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 402 PLEIVTSRQWYIRNGGRPwtrpasgADLNDELVERGRQLDFHPDFMRVRYENWVRGLKGDWLVSRQRFFGVPFPLWYRVG 481
Cdd:NF000540 379 PLEIVSTRQWYIRNGGRD-------ADLREALLARGRELAWHPEHMRVRYENWVEGLNGDWLISRQRFFGVPFPVWYPLD 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 482 ADGQVDYDAVITPSEDSLPVDPSTDAPEGFTEEQRGEPGGFVGELDIMDTWATSSLSPQLACGWLHDDDLFARTYPMDLR 561
Cdd:NF000540 452 ADGEPDYDAPIVPAEDQLPVDPSSDVPPGYTEDQRGVPGGFIGDPDVMDTWATSSLTPQIAGGWERDPDLFARVFPMDLR 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 562 PQGQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASARLGLDAA 641
Cdd:NF000540 532 PQGHDIIRTWLFSTVVRAHLEHGSLPWRHAAISGWILDPDRKKMSKSKGNVVTPTGLLEQHGSDAVRYWAASARPGTDTA 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 642 FDEQQMKIGRRLAIKVLNASKFALTMGGEGArldlDPALVTVDLDRSVLAELAGVVAEATDALASYDHARALEVTESFFW 721
Cdd:NF000540 612 FDETQMKVGRRLAIKLLNASKFVLGFGAPAG----DPAAVTEPLDRAMLAALAEVVEQATAAFEAYDYTRALEVTESFFW 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 722 TFCDDYLELVKERAYnreGAWDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWSWYREGSVHTAPWPT-GAPLASAA 800
Cdd:NF000540 688 TFCDDYLELVKERAY---GADGEAAAASARAALATALSVLLRLFAPFLPFATEEVWSWWQEGSVHRAAWPTaDELELPAD 764
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 541492522 801 GDPSVLAAASGALIALRRVKSEAKVSPRTPFLSVVLEAPATSLGALQSVKGDLEAA 856
Cdd:NF000540 765 GDPALLALASAALAGIRKAKSEAKVSMRTPVARATVTGPAAQLALLEAAEDDLRAA 820
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-858 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 1254.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 1 MPDRAVPEGLEHKWGSAWEAEGTYAFDRTAaREQVYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGW 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDE-RKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 81 DDNGLPTERRVQNYFGVRVDatlpydpdfepphvggegksikardqkPISRRNFVELCERLTVEDEAQFEALWRYLGLSV 160
Cdd:PRK13208 85 DDNGLPTERKVEKYYGIRKD---------------------------DISREEFIELCRELTDEDEKKFRELWRRLGLSV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 161 DWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREYPGFYHRIAFHltdasaaaeaara 240
Cdd:PRK13208 138 DWSLEYQTISPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFP------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 241 gapVEDGADVCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPAAEKDKGAGIAMCCTFGDTTDI 320
Cdd:PRK13208 205 ---VEDGEEIEIATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 321 DWWRDLGLPLRAILRKDGRIVAdtpewitteagrtAFAEISGKTTFSAREAVVARLRgSGELKGEPTKTVRQTNFFEKGD 400
Cdd:PRK13208 282 TWWRELNLPTRIIIDEDGRMTE-------------AAGKLAGLTIEEARKKIVEDLK-SGGLLGKQEPIKHNVKFCERCD 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 401 KPLEIVTSRQWYIRNggrpwtrpasgADLNDELVERGRQLDFHPDFMRVRYENWVRGLKGDWLVSRQRFFGVPFPLWYRV 480
Cdd:PRK13208 348 TPLEILVTRQWFIKV-----------LDLKEELLERGKEINWYPEHMRVRLENWIEGLNWDWCISRQRYFGTPIPVWYCK 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 481 gadgqvDYDAVITPSEDSLPVDPSTDAPEGFTEEQRGEpGGFVGELDIMDTWATSSLSPQLACGWLHDDDLFARTYPMDL 560
Cdd:PRK13208 417 ------DCGHPILPDEEDLPVDPTKDEPPGYKCPQCGS-PGFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDL 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 561 RPQGQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASARLGLDA 640
Cdd:PRK13208 490 RPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSDT 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 641 AFDEQQMKIGRRLAIKVLNASKFALTMGGEGArldLDPALVTVDLDRSVLAELAGVVAEATDALASYDHARALEVTESFF 720
Cdd:PRK13208 570 PFDEKQVKIGRRLLTKLWNASRFVLHFSADPE---PDKAEVLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFF 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 721 W-TFCDDYLELVKERAYNREGAwdgASAASARAALALVIDTVVRLLAPYLPFVTEEVWSWYREGSVHTAPWPTGAPLASA 799
Cdd:PRK13208 647 WhVFCDDYLELVKSRAYGEDEE---EEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGGSVHRASWPEPDEELID 723
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 541492522 800 AGDPSVLAAASGALIALRRVKSEAKVSPRTPFLSVVLEAPAtSLGALQSVKGDLEAASK 858
Cdd:PRK13208 724 EEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPA-DLELLEAAEEDLKAAGN 781
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-884 |
9.94e-179 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 538.49 E-value: 9.94e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 1 MPDRAVPEGLEHKWGSAWEAEGTYAFDRTAAREQvYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGW 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPP-FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 81 DDNGLPTErrvqnyfgVRVDATLpydpdfepphvggeGKSIKARDQkpISRRNFVELCERLTVEDEAQFEALWRYLGLSV 160
Cdd:TIGR00422 80 DHAGIATQ--------VKVEKKL--------------GAEGKTKHD--LGREEFREKIWEWKEESGGTIKNQIKRLGASL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 161 DWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREYPGFYHRIAFhltdasaaaeaara 240
Cdd:TIGR00422 136 DWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRY-------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 241 gaPVEDGA--DVCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPAAEKDKGAGIAMCCTFGDTT 318
Cdd:TIGR00422 202 --PLANGSkdYLVVATTRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFN 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 319 DIDWWRDLGLPLRAILRKDGRIVADTPEWitteagrtafaeiSGKTTFSAREAVVARLRGSGEL-KGEPTKtvRQTNFFE 397
Cdd:TIGR00422 280 DYEWGKRHNLEFINILDEDGLLNENAGKY-------------QGLTRFEARKKIVEDLKEEGLLvKIEPHT--HNVGTCW 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 398 KGDKPLEIVTSRQWYIRnggrpwtrPASGADLNDELVERGrQLDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPLW 477
Cdd:TIGR00422 345 RSGTVVEPLLSKQWFVK--------VEKLADKALEAAEEG-EIKFVPKRMEKRYLNWLRNIK-DWCISRQLIWGHRIPVW 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 478 YrvgadgQVDYDAVITPSEDSLPVDPSTDAPEGfteeqrgepgGFVGELDIMDTWATSSLSPQLACGWLHDDDLFARTYP 557
Cdd:TIGR00422 415 Y------CKECGEVYVAKEEPLPDDKTNTGPSV----------ELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYP 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 558 MDLRPQGQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAAS-ARL 636
Cdd:TIGR00422 479 TDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASlVTP 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 637 GLDAAFDEQQMKIGRRLAIKVLNASKFALTMGGEgaRLDLDPALVTV-DLDRSVLAELAGVVAEATDALASYDHARALEV 715
Cdd:TIGR00422 559 GDDINFDWKRVESARNFLNKLWNASRFVLMNLSD--DLELSGGEEKLsLADRWILSKLNRTIKEVRKALDKYRFAEAAKA 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 716 TESFFW-TFCDDYLELVKERAYNREGAwdgaSAASARAALALVIDTVVRLLAPYLPFVTEEVWSWYREG--SVHTAPWPT 792
Cdd:TIGR00422 637 LYEFIWnDFCDWYIELVKYRLYNGNEA----EKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGadSIMLQSYPV 712
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 793 GAPlasAAGDPSvlAAASGALI-----ALRRVKSEAKVSPRTP-FLSVVLEApATSLGALQSVKGDLEAASKAVGALALV 866
Cdd:TIGR00422 713 VDA---EFVDEE--AEKAFELLkeiivSIRNLKAESNIPPNAPlKVLLIYTE-AETAERLKLNAVDIKGAINFSEVEVVI 786
|
890
....*....|....*...
gi 541492522 867 AASEDSEAAEAVVKSFEL 884
Cdd:TIGR00422 787 EKPEVTEAVVELVPGFEI 804
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
35-642 |
5.29e-111 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 345.77 E-value: 5.29e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 35 VYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQNYFGVrvdatlpydpdfepphv 114
Cdd:cd00817 2 VFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGI----------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 115 ggegKSIKARDqkpISRRNFVELCERLTVEDEAQFEALWRYLGLSVDWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAE 194
Cdd:cd00817 65 ----EGKTRHD---LGREEFLEKCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 195 APGLWDVTFQTAVAQAElesreypgfyhriafhltdasaaaeaaragapvedgadVCvettrpellaacvaliahpdder 274
Cdd:cd00817 138 RLVNWCPKLRTAISDIE--------------------------------------VC----------------------- 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 275 ykplfgktvaspvygvevpvlahpaaekdkgagiamcctfgdttdidwwrdlglplrailrkdgrivadtpewitteagr 354
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 355 tafaeisgkttfsareavvarlrgsgelkgeptktvrqtnffEKGDKPLEIVTSRQWYIRNGgrpwtrpasgaDLNDELV 434
Cdd:cd00817 157 ------------------------------------------SRSGDVIEPLLKPQWFVKVK-----------DLAKKAL 183
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 435 ERGRQ--LDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPLWYrvgadgQVDYDAVITPSEDSLPVDPSTDApegft 512
Cdd:cd00817 184 EAVKEgdIKFVPERMEKRYENWLENIR-DWCISRQLWWGHRIPAWY------CKDGGHWVVAREEDEAIDKAAPE----- 251
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 513 EEQRGEPGGFVGELDIMDTWATSSLSPQLACGWLHDDDLFARTYPMDLRPQGQDIIRTWLFSTVVRADLEFGALPWRHAG 592
Cdd:cd00817 252 ACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVY 331
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 541492522 593 LSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASA-RLGLDAAF 642
Cdd:cd00817 332 LHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAaTQGRDINL 382
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
7-884 |
2.85e-101 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 335.15 E-value: 2.85e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 7 PEGLEHKWGSAWEAEGtyAFDRTAAREQVYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLP 86
Cdd:PRK05729 11 PKEVEAKWYQKWEEKG--YFKPDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHAGIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 87 TErrvqnyfgVRVDATLpydpdfepphvGGEGKSikaRDQkpISRRNFVELCERLTVEDEAQFEALWRYLGLSVDWKQNY 166
Cdd:PRK05729 89 TQ--------MVVERQL-----------AAEGKS---RHD--LGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRER 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 167 QTIGRRARKVAQAAFLRNLARGEAYQAEApgL--WDVTFQTAVAQAELESREYPG-FYHrIAFhltdasaaaeaaragaP 243
Cdd:PRK05729 145 FTMDEGLSKAVREVFVRLYEKGLIYRGKR--LvnWDPKLQTALSDLEVEYKEVKGkLWH-IRY----------------P 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 244 VEDGAD-VCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPAAEKDKGAGiAMCCTFG-DTTDID 321
Cdd:PRK05729 206 LADGSDyLVVATTRPETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTG-AVKITPAhDPNDFE 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 322 WWRDLGLPLRAILRKDGRIVAdtpewittEAGRtaFAeisGKTTFSAREAVVARLRGSGEL-KGEPTKTvrQTNFFEKGD 400
Cdd:PRK05729 285 VGKRHNLPMINIMDEDGTINE--------NPGE--YQ---GLDRFEARKAIVADLEELGLLvKIEPHTH--SVGHSDRSG 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 401 KPLEIVTSRQWYIRngGRPWTRPASgadlndELVERGRqLDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPLWYrv 480
Cdd:PRK05729 350 VVIEPYLSDQWFVK--MKPLAKPAL------EAVENGE-IKFVPERWEKTYFHWMENIQ-DWCISRQLWWGHRIPAWY-- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 481 GADGQVdydaVITPSEDslpvdpstDAPEGFTEEQrgEPggfvgelDIMDTWATSSLSPqLAC-GWLHDDDLFARTYPMD 559
Cdd:PRK05729 418 DEDGEV----YVGREEP--------EAREKALLTQ--DE-------DVLDTWFSSALWP-FSTlGWPEKTEDLKRFYPTS 475
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 560 LRPQGQDIIRTWlfstVVR---ADLEF-GALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRY-WAASA 634
Cdd:PRK05729 476 VLVTGFDIIFFW----VARmimMGLHFtGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFtLAALA 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 635 RLGLDAAFDEQQMKIGRRLAIKVLNASKFALTMGGEGARLDLDPALVTVDLDRSVLAELAGVVAEATDALASYDHARALE 714
Cdd:PRK05729 552 SPGRDIRFDEERVEGYRNFANKLWNASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAAR 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 715 VTESFFW-TFCDDYLELVKERAYNREGAwdgasaaSARAALALVIDTVVRLLAPYLPFVTEEVW----SWYREGSVHTAP 789
Cdd:PRK05729 632 ALYEFIWnEFCDWYLELAKPVLQEAAKR-------ATRATLAYVLEQILRLLHPFMPFITEELWqklaPLGIEESIMLAP 704
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 790 WPTgaplASAAGDPSVLAAAS---GALIALRRVKSEAKVSPRTPFLSVVLEAPATSLGALQSVKGDLEAASKAVGALALV 866
Cdd:PRK05729 705 WPE----ADEAIDEAAEAEFEwlkELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILA 780
|
890
....*....|....*....
gi 541492522 867 AASEDSE-AAEAVVKSFEL 884
Cdd:PRK05729 781 DDEEAPEgAASAVVGGAEL 799
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
7-846 |
2.03e-90 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 305.82 E-value: 2.03e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 7 PEGLEHKWGSAWEAEGTYAFDRTAAREQvYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLP 86
Cdd:COG0525 9 PKEVEAKWYQYWEENGYFKADPDSDKEP-FTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTDHAGIA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 87 TErrvqnyfgVRVDATLpydpdfepphvGGEGKSikaRDQkpISRRNFVELC--------ERLTvedeAQfealWRYLGL 158
Cdd:COG0525 88 TQ--------AVVERQL-----------AEEGKS---RHD--LGREKFLERVwewkeesgGTIT----NQ----LRRLGA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 159 SVDWKQNYQTI--GR-RA-RKVaqaaFLRnLargeaYQAeapGL---------WDVTFQTAVAQAELESREYPG-FYHrI 224
Cdd:COG0525 136 SCDWSRERFTMdeGLsKAvREV----FVR-L-----YEK---GLiyrgkrlvnWDPKLKTALSDLEVEHEEVKGhLWH-I 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 225 AFhltdasaaaeaaragaPVEDGAD-VCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPAAEKD 303
Cdd:COG0525 202 RY----------------PLADGSGyIVVATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPE 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 304 KGAGiAMCCTFG-DTTDIDWWRDLGLPLRAILRKDGRIVAdtpewittEAGRtaFAeisGKTTFSAREAVVARLRGSGEL 382
Cdd:COG0525 266 FGTG-AVKITPAhDPNDFEVGKRHNLPMINILDEDGTINE--------NAGK--YR---GLDRFEARKAIVADLEELGLL 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 383 -KGEPTKTvrQTNFFEKGDKPLEIVTSRQWYIRNggRPWTRPASgadlndELVERGRqLDFHPDFMRVRYENWVRGLKgD 461
Cdd:COG0525 332 vKVEPHKH--SVGHSDRSGTVIEPYLSDQWFVKM--KPLAKPAI------EAVEDGE-IKFVPERWEKTYFHWMENIR-D 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 462 WLVSRQRFFGVPFPLWYrvGADGQVDydavitpsedslpVdpSTDAPEgftEEQRGEPGGFVGELDIMDTWATSSLSPQL 541
Cdd:COG0525 400 WCISRQLWWGHRIPAWY--CPDGEVY-------------V--ARTEPE---ACAKAGSVNLTQDEDVLDTWFSSALWPFS 459
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 542 ACGWLHDDDLFARTYPMDLRPQGQDIIRTWlfstVVR---ADLEF-GALPWRHAGLSGWILDADHKKMSKSKGNVVTPMG 617
Cdd:COG0525 460 TLGWPEKTEDLKYFYPTSVLVTGFDIIFFW----VARmimMGLHFtGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLD 535
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 618 LLEKYGSDAVRY-WAASARLGLDAAFDEQQMKIGRRLAIKVLNASKFALtMGGEGARLDLDPALVTVDL-DRSVLAELAG 695
Cdd:COG0525 536 LIDKYGADALRFtLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVL-MNLEGFDPGLDPDPEELSLaDRWILSRLNK 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 696 VVAEATDALASYDHARALEVTESFFW-TFCDDYLELVKERAYNRegawDGASAASARAALALVIDTVVRLLAPYLPFVTE 774
Cdd:COG0525 615 TIAEVTEALEKYRFDEAAQALYDFVWnEFCDWYLELAKPRLYGG----DEAAKRETRATLVYVLEQILRLLHPFMPFITE 690
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 541492522 775 EVWS----WYREGSVHTAPWPTGAPlasAAGDPSVLAAAS---GALIALRRVKSEAKVSPRTPfLSVVLEAPATSLGAL 846
Cdd:COG0525 691 EIWQklppRKEGESIMLAPWPEADE---ELIDEEAEAEFEwlkEVISAIRNIRAEMNIPPSKK-LPLLLKGADEADRAR 765
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
12-827 |
9.42e-84 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 289.15 E-value: 9.42e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 12 HKWgsaWEAEGTYAFDRTAAREQvYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRV 91
Cdd:PLN02943 70 YNW---WESQGYFKPNFDRGGDP-FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 92 QNYfgvrvdatlpydpdfepphVGGEGksIKARDqkpISRRNFVELCERLTVEDEAQFEALWRYLGLSVDWKQNYQTIGR 171
Cdd:PLN02943 146 EKM-------------------LASEG--IKRTD---LGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 172 RARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREYPGFYHRIAFhltdasaaaeaaragaPVEDGAD-- 249
Cdd:PLN02943 202 QLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKY----------------RVAGGSEdf 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 250 VCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPV-YGVEVPVLAHPAAEKDKGAGIAMCCTFGDTTDIDWWRDLGL 328
Cdd:PLN02943 266 LTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMtYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 329 PLRAILRKDGRIvadtpewitteagrtafAEISGKTTFSAREAVVARLRGSG-ELKGEP-TKTVRQTnffEKGDKPLEIV 406
Cdd:PLN02943 346 PILNVMNKDGTL-----------------NEVAGLYWFEAREKLWSDLEETGlAVKKEPhTLRVPRS---QRGGEVIEPL 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 407 TSRQWYIRNggRPWTRPASGAdlndelVERGrQLDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPLWYRVGADGQV 486
Cdd:PLN02943 406 VSKQWFVTM--EPLAEKALKA------VENG-ELTIIPERFEKIYNHWLSNIK-DWCISRQLWWGHRIPVWYIVGKDCEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 487 DYdaVITPSEDslpvdpstDAPEGfTEEQRGEPGGFVGELDIMDTWATSSLSPQLACGW--LHDDDlFARTYPMDLRPQG 564
Cdd:PLN02943 476 DY--IVARSAE--------EALEK-AREKYGKDVEIYQDPDVLDTWFSSALWPFSTLGWpdVSAED-FKKFYPTTVLETG 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 565 QDIIRTWLfSTVVRADLEF-GALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASARLGLDAAFD 643
Cdd:PLN02943 544 HDILFFWV-ARMVMMGIEFtGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLS 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 644 EQQMKIGRRLAIKVLNASKFAL--------TMGGEGAR---LDLDPALVTVDL-DRSVLAELAGVVAEATDALASYDHAR 711
Cdd:PLN02943 623 TERLTSNKAFTNKLWNAGKFVLqnlpsqsdTSAWEHILackFDKEESLLSLPLpECWVVSKLHELIDSVTTSYDKYFFGD 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 712 ALEVTESFFWT-FCDDYLELVKERAYNREgawDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWSW--YREGSVHTA 788
Cdd:PLN02943 703 VGREIYDFFWSdFADWYIEASKTRLYHSG---DNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAlpYRKEALIVS 779
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 541492522 789 PWP-TGAPLasaagDPSVLAAASG--ALI-ALRRVKSEAKVSP 827
Cdd:PLN02943 780 PWPqTSLPK-----DLKSIKRFENlqSLTrAIRNARAEYSVEP 817
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
7-829 |
4.04e-82 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 286.12 E-value: 4.04e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 7 PEGLEHKWGSAWEAEGTYAFDRTAAREQVYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLP 86
Cdd:PRK14900 21 HREVEARWYPFWQERGYFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 87 TERRVQNyfgvrvdatlpydpdfepphvggEGKSIKARDQKPISRRNFVELCERLTVEDEAQFEALWRYLGLSVDWKQNY 166
Cdd:PRK14900 101 TQMIVEK-----------------------ELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 167 QTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESRE-YPGFYHRIAFhltdasaaaeaaragaPVE 245
Cdd:PRK14900 158 FTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEaHQGELWSFAY----------------PLA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 246 DG-ADVCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPAAEKDK-GAGIAMCCTFGDTTDIDWW 323
Cdd:PRK14900 222 DGsGEIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAILVDPKfGTGAVKVTPAHDFNDFEVG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 324 RDLGLPLRAILRKDGRivadtpewITTEAGRTAfaeisGKTTFSAREAVVARLRGSGELKGEPTKtVRQTNFFEKGDKPL 403
Cdd:PRK14900 302 KRHGLEMITVIGPDGR--------MTAEAGPLA-----GLDRFEARKEVKRLLAEQGLDRGAKPH-VLPLGRCQRSATIL 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 404 EIVTSRQWYIRNggRPWTRPASgadlndELVERGRQlDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPLWYrvGAD 483
Cdd:PRK14900 368 EPLLSDQWYVRI--EPLARPAI------EAVEQGRT-RFIPEQWTNTYMAWMRNIH-DWCISRQLWWGHQIPAWY--CPD 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 484 GQVDYdAVITPSEdslpvdpstdAPEGFTEEQRGEPggfvgelDIMDTWATSSLSPQLACGWLHDDDLFARTYPMDLRPQ 563
Cdd:PRK14900 436 GHVTV-ARETPEA----------CSTCGKAELRQDE-------DVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMET 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 564 GQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRY-WAASARLGLDAAF 642
Cdd:PRK14900 498 GHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFtLAALTAQGRDIKL 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 643 DEQQMKIGRRLAIKVLNASKFALTMGGEGARLDLDPALVTVDL-DRSVLAELAGVVAEATDALASYDHARALEVTESFFW 721
Cdd:PRK14900 578 AKERIEGYRAFANKLWNASRFALMNLSGYQERGEDPARLARTPaDRWILARLQRAVNETVEALEAFRFNDAANAVYAFVW 657
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 722 -TFCDDYLELVKERAYNRegawDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWSWYReGSVHTAPWPTGAPLAS-- 798
Cdd:PRK14900 658 hELCDWYIELAKEALASE----DPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLR-AQVGASAWADSVLAAEyp 732
|
810 820 830
....*....|....*....|....*....|....*.
gi 541492522 799 --AAGDPSVLAAAS---GALIALRRVKSEAKVSPRT 829
Cdd:PRK14900 733 rkGEADEAAEAAFRpvlGIIDAVRNIRGEMGIPWKV 768
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-643 |
1.95e-73 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 252.72 E-value: 1.95e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 13 KWGSAWEAEGTYAFDRTAAREQ-VYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRV 91
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKpSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 92 QNYFGVRvdatlpydpdfepphvggEGKsikarDQKPISRRNFVELCERLTVEDEAQFEALWRYLGLSVDWKQNYQTIGR 171
Cdd:pfam00133 81 EKKLGIK------------------EKK-----TRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDP 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 172 RARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREYPGFYHRIAFhltdasaaaeaaragaPVEDGADVC 251
Cdd:pfam00133 138 ELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVKGPSIHVAF----------------PLADDEGAS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 252 VE--TTRPELLAACVALIAHPD-------------------------------DERYKPLFGKTVASPVYGVEVPVLAHP 298
Cdd:pfam00133 202 LViwTTTPWTLPGNTAVAVNPEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDD 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 299 AAEKDKGAGIAMCCTFGDTTDIDWWRDLGLPLRAILRKDGRIVADTPEWItteagrtafaeisGKTTFSAREAVVARLRG 378
Cdd:pfam00133 282 YVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQ-------------GVYRFDARKKIVELLTE 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 379 SGELKgEPTKTVRQTNFFEKGDKPLEIVTSRQWYIRNggrpwtrpasgADLNDELVERGRQLDFHPDFMRVRYENWVRGL 458
Cdd:pfam00133 349 KGLLL-KIEPFTHSYPFCWRSGTPIIPRATPQWFVRM-----------DELADQALEAVEKVQFVPKSGEKRYFNWLANI 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 459 kGDWLVSRQRFFGVPFPLWY-----RVGADGQVDYDAVitpsEDSLPVDPSTDAPEGFTEEQRGEPGGFVGELDIMDTWA 533
Cdd:pfam00133 417 -QDWCISRQRWWGHPIPAWVskdteEVVCRGELFELVA----GRFEEEGSIKWLHREAKDKLGYGKGTLEQDEDVLDTWF 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 534 TSSLSPQLACGW-LHDDDLFARTYPMDLRPQGQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNV 612
Cdd:pfam00133 492 SSGSWPFSTLGWpFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNV 571
|
650 660 670
....*....|....*....|....*....|.
gi 541492522 613 VTPMGLLEKYGSDAVRYWAASARLGLDAAFD 643
Cdd:pfam00133 572 IDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-792 |
2.28e-58 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 216.80 E-value: 2.28e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 1 MPDRAVPEGLEHKWGSAWEAEGTY-AFDRTAA--REQVYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYP 77
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFkPAEDAKSlnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 78 MGWDDNGLPT----ERRVQNyfgvrvdatlpydpdfepphvgGEGKSikaRDQkpISRRNFVE------------LCERL 141
Cdd:PTZ00419 104 PGTDHAGIATqvvvEKKLMK----------------------EENKT---RHD--LGREEFLKkvwewkdkhgnnICNQL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 142 tvedeaqfealwRYLGLSVDWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREY---- 217
Cdd:PTZ00419 157 ------------RRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIekpt 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 218 ----PGFYHRIAF-HLTdasaaaeaaRAGAPVEDGAD--VCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVY-G 289
Cdd:PTZ00419 225 kitiPGYDKKVEVgVLW---------HFAYPLEDSGQeeIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIpD 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 290 VEVPVLAHPA-AEKDKGAGIAMCCTFGDTTDIDWWRDLGLPLRAILRKDGRivadtpewITTEAGrtafaEISGKTTFSA 368
Cdd:PTZ00419 296 RKIPIIADDElVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGK--------INENGG-----EFAGMHRFDC 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 369 REAVVARLRGSGELKGEpTKTVRQTNFFEKGDKPLEIVTSRQWYIrnggrpwtrpaSGADLNDELVE--RGRQLDFHPDF 446
Cdd:PTZ00419 363 RRKIEEELKEMGLLRDK-VPNPMRLPRCSRSGDIVEPMLIPQWYV-----------NCKDMAKRAVEavRNGELKIIPSS 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 447 MRVRYENWVRGLKgDWLVSRQRFFGVPFPLwYRVgadgqvdydAVITPSEDSLPVDP-----------------STDAPE 509
Cdd:PTZ00419 431 HENVWYHWLENIQ-DWCISRQLWWGHRIPA-YRV---------ISKGPETDPSDEEPwvvarseeealekakkkFGLSEE 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 510 GFTEEQrgepggfvgELDIMDTWATSSLSPQLACGWLHDDDLFARTYPMDLRPQGQDIIRTWLfSTVVRADLEF-GALPW 588
Cdd:PTZ00419 500 DFELEQ---------DEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWV-ARMVMMSLHLtDKLPF 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 589 RHAGLSGWILDADHKKMSKSKGNVVTPM---------GLLEKY----------------------------GSDAVRY-W 630
Cdd:PTZ00419 570 KTVFLHAMVRDSQGEKMSKSKGNVIDPLeviegislqDLNQKLyegnlpekeikraielqkkefpngipecGTDALRFgL 649
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 631 AASARLGLDAAFDEQQMKIGRRLAIKVLNASKFALtMGGEGAR----LDLDPALVTVDL---DRSVLAELAGVVAEATDA 703
Cdd:PTZ00419 650 LAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFAL-MKLLKDFnlpnSTLFKPNNVESLpweDKWILHRLNVAIKEVTEG 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 704 LASYDHARALEVTESFF-WTFCDDYLELVKERAYNREgawDGASAASARAALALVIDTVVRLLAPYLPFVTEEVW----- 777
Cdd:PTZ00419 729 FKEYDFSEATQATYNFWlYELCDVYLELIKPRLSKQS---DGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYqrlpn 805
|
890
....*....|....*
gi 541492522 778 SWYREGSVHTAPWPT 792
Cdd:PTZ00419 806 YLRKSESISIAKYPQ 820
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
2-854 |
3.19e-57 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 212.63 E-value: 3.19e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 2 PDRAVPEGLEHKWGSAWEAEGTYA--FDRTAAREQVYSIDTPPpTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMG 79
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYEksREARAGRPKFVLHDGPP-YANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 80 WDDNGLPTERRVQNYFGvrvdatlpydpdfepphvggegksIKARDQKPISRRNFVELC----ERLTVEDEAQFEalwRy 155
Cdd:COG0060 92 WDCHGLPIELKVEKELG------------------------IKKKDIEKVGIAEFREKCreyaLKYVDEQREDFK---R- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 156 LGLSVDWKQNYQTIGRRArkVAQA--AFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESREY--PGFYhrIAFHLTDA 231
Cdd:COG0060 144 LGVWGDWDNPYLTMDPEY--EESIwwALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVtsPSIY--VKFPVKDE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 232 SAAaeaaragaPVEDGADVCVETTRPELLAACVALIAHPD----------DERY---KPLFGKTVASpvYGVE-VPVLA- 296
Cdd:COG0060 220 KAL--------LLLEDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaEALVEAVLKE--LGIEdYEVLAt 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 297 ------------HP--AAEKDKGAGIAMCctfGD--TT----------------DIDWWRDLGLPLRAILRKDGRIVADT 344
Cdd:COG0060 290 fkgaeleglryeHPfyYVVGYDRAHPVIL---GDyvTTedgtgivhtapghgedDFEVGKKYGLPVLNPVDDDGRFTEEA 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 345 PEWitteagrtafaeiSGKTTFSAREAVVARLRGSGELkgeptktvrqtnfFEKG------------DKPLeI--VTSrQ 410
Cdd:COG0060 367 PLF-------------AGLFVKDANPAIIEDLKERGAL-------------LAREkithsyphcwrcKTPL-IyrATP-Q 418
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 411 WYIRNGgrpwtrpasgaDLNDELVERGRQLDFHPDFMRVRYENWVRGLkGDWLVSRQRFFGVPFPLWY------------ 478
Cdd:COG0060 419 WFISMD-----------KLRDRALEAIEKVNWIPEWGEGRFGNMLENR-PDWCISRQRYWGVPIPIWVcedcgelhrtee 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 479 -------RVGADGqVDYDAVITPSEDSLpvdpstdaPEGFTEEQRGEPggFVGELDIMDTWATSSLSPqlACGWLHDDDL 551
Cdd:COG0060 487 vigsvaeLLEEEG-ADAWFELDLHRPFL--------DETLKCPKCGGT--MRRVPDVLDVWFDSGSMH--FAVLENREEL 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 552 farTYPMDLRPQGQDIIRTWLFSTVVRADLEFGALPWR----HaglsGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAV 627
Cdd:COG0060 554 ---HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKnvltH----GFVLDEDGRKMSKSLGNVVDPQEVIDKYGADIL 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 628 RYWAASARLGLDAAFDEQQMKIGRRLAIKVLNASKFALtmggegARLD-LDPALVTVD------LDRSVLAELAGVVAEA 700
Cdd:COG0060 627 RLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLL------ANLDdFDPAEDAVPyedlpeLDRWILSRLNELIKEV 700
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 701 TDALASYD-H--ARALEvtesffwTFCDD-----YLELVKERAYnrEGAWDGASAASARAALALVIDTVVRLLAPYLPFV 772
Cdd:COG0060 701 TEAYDNYDfHraYRALH-------NFCVEdlsnwYLDISKDRLY--TEAADSLDRRAAQTTLYEVLETLVRLLAPILPFT 771
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 773 TEEVWSWY---REGSVHTAPWPTGAPlasAAGDPSVLA----------AASGALIALRRvkseAKV--SPrtpfLS--VV 835
Cdd:COG0060 772 AEEIWQNLpgeAEESVHLADWPEVDE---ELIDEELEAkwdlvrevrsAVLKALEAARK----EKLirQP----LEaaVV 840
|
970
....*....|....*....
gi 541492522 836 LEAPATSLGALQSVKGDLE 854
Cdd:COG0060 841 LYADEELAAALESLGDLLA 859
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-777 |
1.01e-55 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 208.98 E-value: 1.01e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 1 MPDRAVPEGLEHKWGSAWEAEGTYAFDRTAAREQvYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGW 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPP-FVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGV 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 81 DDNGLPTERRVqnyfgvrvdatlpydpdfepphvggEGKSIKARD--QKPISRRNFVElcERLTVEDEAQFEAL--WRYL 156
Cdd:PLN02381 175 DHAGIATQVVV-------------------------EKKLMRERHltRHDIGREEFVS--EVWKWKDEYGGTILnqLRRL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 157 GLSVDWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELESRE--------YPGFYHRIAFHL 228
Cdd:PLN02381 228 GASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDikertllkVPGYDKPVEFGV 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 229 TdasaaaeaARAGAPVEDG-ADVCVETTRPELLAACVALIAHPDDERYKPLFGKTVASPVYGVEVPVLAHPA-AEKDKGA 306
Cdd:PLN02381 308 L--------TSFAYPLEGGlGEIVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAIlVDPNFGT 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 307 GIAMCCTFGDTTDIDWWRDLGLPLRAILRKDGRivadtpewITTEAGrtafAEISGKTTFSAREAVVARLRGSGELKGEP 386
Cdd:PLN02381 380 GAVKITPAHDPNDFEVGKRHNLEFINIFTDDGK--------INSNGG----SEFAGMPRFAAREAVIEALQKKGLYRGAK 447
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 387 TKTVRqTNFFEKGDKPLEIVTSRQWYIRnggrpwTRPASGADLNDELVERGRQLDFHPDFMRVRYENWVRGLKgDWLVSR 466
Cdd:PLN02381 448 NNEMR-LGLCSRTNDVVEPMIKPQWFVN------CSSMAKQALDAAIDGENKKLEFIPKQYLAEWKRWLENIR-DWCISR 519
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 467 QRFFGVPFPLWYRVGADgqvDYDAVITPSEDSLPVdpSTDAPEGFTEEQRGEPGG---FVGELDIMDTWATSSLSPQLAC 543
Cdd:PLN02381 520 QLWWGHRIPAWYVTLED---DQLKELGSYNDHWVV--ARNESDALLEASQKFPGKkfeLSQDPDVLDTWFSSGLFPLSVL 594
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 544 GWLHDDDLFARTYPMDLRPQGQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPM------- 616
Cdd:PLN02381 595 GWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLevingis 674
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 617 --GLLEKY----------------------------GSDAVR-----YWAASARLGLDAafdeqQMKIG-RRLAIKVLNA 660
Cdd:PLN02381 675 leGLHKRLeegnldpkelvvakegqkkdfpngiaecGTDALRfalvsYTAQSDKINLDI-----LRVVGyRQWCNKLWNA 749
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 661 SKFALtmggegARLDLD---PALVTVDLD----RSVLAELAGVVAEATDALASYDHARALEVTESFF-WTFCDDYLELVK 732
Cdd:PLN02381 750 VRFAM------SKLGDDytpPATLSVETMpfscKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWqYQFCDVFIEAIK 823
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*..
gi 541492522 733 ------------ERAYNREGAWdgasaasaraalaLVIDTVVRLLAPYLPFVTEEVW 777
Cdd:PLN02381 824 pyfagdnpefasERAAAQDTLW-------------ICLDTGLRLLHPFMPFVTEELW 867
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
35-633 |
5.43e-38 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 144.48 E-value: 5.43e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 35 VYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQnyfgvrvdatlpydpdfepphv 114
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAE---------------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 115 ggegkSIKARDQKPISRRNFVELCERLTVEDEAQFEALWRylglsvdwkqnyqtigrrarkvaqaaflrnlargeayqae 194
Cdd:cd00668 59 -----RKGGRKKKTIWIEEFREDPKEFVEEMSGEHKEDFR---------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 195 apglwdvtfqtavaqaelesreypgfyhriafhltdasaaaeaaragapvedgadvcvettrpellaacvaliahpdder 274
Cdd:cd00668 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 275 ykplfgktvaspvygvevpvlahpaaekdkGAGIAmcctfgdttdIDWWRdlglplrailrkdgrivadtpEWITTEAGR 354
Cdd:cd00668 94 ------------------------------RLGIS----------YDWSD---------------------EYITTEPEY 112
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 355 TAFAEISGKttfsareavvarlrgsgelkgeptktvrqtNFFEKGD---KPLEIVTSRQWYIRNGgrpwtrpasgaDLND 431
Cdd:cd00668 113 SKAVELIFS------------------------------RLYEKGLiyrGTHPVRITEQWFFDMP-----------KFKE 151
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 432 ELVERGRQLDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPLWYrvgadgqvdydavitpsedslpvdpstdapegf 511
Cdd:cd00668 152 KLLKALRRGKIVPEHVKNRMEAWLESLL-DWAISRQRYWGTPLPEDV--------------------------------- 197
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 512 teeqrgepggfvgeldiMDTWATSSLSPQLACGWLHDDDLFARTYPMDLRPQGQDIIRTWLFSTVVRADLEFGALPWRHA 591
Cdd:cd00668 198 -----------------FDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNL 260
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 541492522 592 GLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAAS 633
Cdd:cd00668 261 LVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTS 302
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-792 |
2.50e-35 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 144.42 E-value: 2.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 1 MPDRAVPEGLEHKWGSAWEAEGTYAFDRTAAREQVYSIDT-PPPtvSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMG 79
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMfPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 80 WDDNGLPTErrvqNYfgvrvdAtlpydpdfepphvggegksIKaRDQKPisrrnfvelcERLTVEDEAQFEALWRYLGLS 159
Cdd:COG0495 79 WDAFGLPAE----NA------A-------------------IK-NGVHP----------AEWTYENIANMRRQLKRLGLS 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 160 VDWKqnyqtigrraRKVA----------QAAFLRNLARGEAYQAEAPGLWDVTFQTAVA--Q----------AELESREY 217
Cdd:COG0495 119 YDWS----------REIAtcdpeyykwtQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLAneQvidgrcwrcgAPVEKKEL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 218 PGFYHRI-------------------------------------AFHLTDAsaaaeaaragapvedGADVCVETTRPELL 260
Cdd:COG0495 189 PQWFLKItdyadellddldkldgwpekvktmqrnwigrsegaevDFPVEGS---------------DEKITVFTTRPDTL 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 261 --AACVALIA-HP------DDERYKPL-------------------------F-GKTVASPVYGVEVP------VLAhpa 299
Cdd:COG0495 254 fgATFMVLAPeHPlvkelaTPEQNAAVaafieeakkkseiertsetkektgvFtGLYAINPLTGEKIPiwiadyVLM--- 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 300 aekDKGAGIAMCCTFGDTTDIDWWRDLGLPLRAILRKDGRIVADTPEWITTEAGrTAF--AEISGKTTFSAREAVVARL- 376
Cdd:COG0495 331 ---DYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAYTGDG-VLInsGEFDGLDSEEAKEAIIEWLe 406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 377 -RGSGElkgeptktvRQTNFfekgdkpleivtsrqwyirnggrpwtrpasgadlndelvergrqldfhpdfmRVRyenwv 455
Cdd:COG0495 407 eKGLGK---------RKVNY----------------------------------------------------RLR----- 420
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 456 rglkgDWLVSRQRFFGVPFPLWYrvGADGQVdydaVITPsEDSLPV--------DPSTDAP----EGF---TEEQRGEPG 520
Cdd:COG0495 421 -----DWLISRQRYWGEPIPIIH--CEDCGV----VPVP-EDQLPVelpedvdfDPTGGSPlaraPEWvnvTCPKCGGPA 488
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 521 gfVGELDIMDTWATSS------LSPqlacgwlHDDDLFArtypmdlrpqGQDIIRTWL--------------------FS 574
Cdd:COG0495 489 --RRETDTMDTFVDSSwyylryTDP-------HNDEAPF----------DPEAANYWLpvdqyiggiehailhllyarFF 549
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 575 TVVRADLefGALPWR-------------HAGLSGwILDADHKKMSKSKGNVVTPMGLLEKYGSDAVR-YWAASARLGLDA 640
Cdd:COG0495 550 TKVLRDL--GLVSFDepfkrlltqgmvlEVGKDG-VVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRlFEMFAGPPERDL 626
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 641 AFDEQQMK-----IGR--RLAIKVLNASKFALTMGGEGARlDLDPAL------VTVDLDR----SVLAELAGVVAEATDA 703
Cdd:COG0495 627 EWSDSGVEgayrfLNRvwRLVVDEAEALKLDVADLSEADK-ELRRALhktikkVTEDIERlrfnTAIAALMELVNALYKA 705
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 704 LASYDHARALevtesffwtfcddylelvkerayNREGawdgasaasaraalalvIDTVVRLLAPYLPFVTEEVWSWY-RE 782
Cdd:COG0495 706 KDSGEADRAV-----------------------LREA-----------------LETLVLLLAPFAPHIAEELWERLgHE 745
|
970
....*....|
gi 541492522 783 GSVHTAPWPT 792
Cdd:COG0495 746 GSVADAPWPE 755
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
642-779 |
3.09e-35 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 130.37 E-value: 3.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 642 FDEQQMKIGRRLAIKVLNASKFALtMGGEGARLDLDPALVTVDLDRSVLAELAGVVAEATDALASYDHARALEVTESFFW 721
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVL-MNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFW 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 541492522 722 -TFCDDYLELVKERAYNRegawDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWSW 779
Cdd:cd07962 80 nDFCDWYLELVKPRLYGE----DEEEKKAARATLYYVLETILRLLHPFMPFITEELWQR 134
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
18-817 |
1.83e-32 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 136.05 E-value: 1.83e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 18 WEAEGTYafDRTAAREQ--VYSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQnyf 95
Cdd:PLN02843 16 WEENQVY--KRVSDRNNgeSFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVL--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 96 gvrvdatlpydpdfepphvggegKSIKARDQK---PISRRNFVELCERLTVEdeAQFEALWRYlGLSVDWKQNYQTIgRR 172
Cdd:PLN02843 91 -----------------------QSLDQEARKeltPIKLRAKAAKFAKKTVD--TQRESFKRY-GVWGDWENPYLTL-DP 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 173 ARKVAQ-AAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAELEsreYP-GfyHR-----IAFHLTDASAAAEAARAgaPVE 245
Cdd:PLN02843 144 EYEAAQiEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELE---YPeG--HVsksiyVAFPVVSPSETSPEELE--EFL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 246 DGADVCVETTRP-------------ELLAACVALIAHPDDERYKP-----LFGKTVASPV-----------------YGV 290
Cdd:PLN02843 217 PGLSLAIWTTTPwtmpanaavavndKLQYSVVEVQSFSEDESTSGgnkkkRPGNVLKEQQklflivatdlvpaleakWGV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 291 EVPVLA-------------HPAAEKDKGAGIAmcctfGD--TTDI--------------DWWRDL--GLPLRAILRKDGR 339
Cdd:PLN02843 297 KLVVLKtfpgsdlegcryiHPLYNRESPVVIG-----GDyiTTESgtglvhtapghgqeDYITGLkyGLPLLSPVDDAGK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 340 IvadtpewiTTEAGrtafaEISGKTTFSA-REAVVARLRGSGEL-KGEPTKTVRQTNFFEKgdKPLEIVTSRQWYirngg 417
Cdd:PLN02843 372 F--------TEEAG-----QFSGLSVLGEgNAAVVEALDEAGSLlMEEAYGHKYPYDWRTK--KPTIFRATEQWF----- 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 418 rpwtrpASGADLNDELVERGRQLDFHPDFMRVRYENWVRGlKGDWLVSRQRFFGVPFPLWYRVGADGQVDYDAVITPSEd 497
Cdd:PLN02843 432 ------ASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSG-RSDWCISRQRTWGVPIPVFYHVETKEPLMNEETIAHVK- 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 498 SLPVDPSTDA------PEGFTEEQRGEPGGFVGELDIMDTWATSSLSPQLACGwlHDDDLfarTYPMDLRPQGQDIIRTW 571
Cdd:PLN02843 504 SIVAQKGSDAwwymdvEDLLPEKYRDKASDYEKGTDTMDVWFDSGSSWAGVLG--SREGL---SYPADLYLEGSDQHRGW 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 572 LFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLE---------KYGSDAVRYWAASARLGLDAAF 642
Cdd:PLN02843 579 FQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWVASVDYTGDVLI 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 643 DEQQMKIGRRLAIKVLNASKFALtmgGEGARLDLDPALVTVDL---DRSVLAELAGVVAEATDALASYDHARALEVTESF 719
Cdd:PLN02843 659 GPQILKQMSDIYRKLRGTLRYLL---GNLHDWKPDNAVPYEDLpsiDKYALFQLENVVNEIEESYDNYQFFKIFQILQRF 735
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 720 -FWTFCDDYLELVKERAYNreGAWDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWSW--YRE-----GSVHTAPWP 791
Cdd:PLN02843 736 tIVDLSNFYLDVAKDRLYV--GGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNlpFQEdgsaaESVFEAGWP 813
|
890 900
....*....|....*....|....*.
gi 541492522 792 TgaPLASAAGDPSVLAAASGALIALR 817
Cdd:PLN02843 814 T--PNEEWLSFPAEDVDFWSLLLEVR 837
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
402-634 |
7.05e-31 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 124.65 E-value: 7.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 402 PLEIVTSRQWYIRNggrpwtrpasgADLNDELVERGRQLDFHPDFMRVRYENWVRGLkGDWLVSRQRFFGVPFPLWYrvg 481
Cdd:cd00818 144 PLIYRATPQWFIRV-----------TKIKDRLLEANDKVNWIPEWVKNRFGNWLENR-RDWCISRQRYWGTPIPVWY--- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 482 adgQVDYDAVITpsedslpvdpstdapegfteeQRGEpggfvgelDIMDTWATSSLSPQLACGWLHDDDLFARTYPMDLR 561
Cdd:cd00818 209 ---CEDCGEVLV---------------------RRVP--------DVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFI 256
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 541492522 562 PQGQDIIRTWLFSTVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASA 634
Cdd:cd00818 257 LEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASS 329
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
49-792 |
4.63e-30 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 128.06 E-value: 4.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 49 LHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPterrvqnyfgvrvdatlpydpdfepphVGGEGKSIKARDQKP 128
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTP---------------------------ILGIAERIARGDPET 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 129 ISR-RNFV----ELCERLT-----VE---DEAQfEALwRYLGLSVDWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEA 195
Cdd:PRK12300 54 IELyKSLYgipeEELEKFKdpeyiVEyfsEEAK-EDM-KRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSH 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 196 PGLWDVTFQTAV--------AQAELEsrEYPGfyhrIAFhltdasaaaeaaragaPVEDGADVCVETTRPELLAACVALI 267
Cdd:PRK12300 132 PVRYCPNDNNPVgdhdlldgEEPEIV--EYTL----IKF----------------EESEDLILPAATLRPETIFGVTNLW 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 268 AHPD---------DERY-------------------------KPLFGKTVASPVYGVEVPVLahPAA--EKDKGAGIAMC 311
Cdd:PRK12300 190 VNPDatyvkaevdGEKWivskeaaeklsfqdrdveiieeikgSELIGKKVKNPVTGKEVPIL--PADfvDPDNGTGVVMS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 312 CTFGDTTDIDWWRDLG----------------------LPLRAILRKDGRIVADTP--EWITTEAGRTAFA--------- 358
Cdd:PRK12300 268 VPAHAPYDYVALRDLKknkelldviepiplievegygeFPAKEVVEKLGIKSQEDPelEEATKEVYRAEFHkgvlkentg 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 359 EISGKTTFSAREAVVARLRGSGelKGEptktvrqtNFFEKGDKPleiVTSR------------QWYIRNGGRPWTRPASg 426
Cdd:PRK12300 348 EYAGKPVREAREKITKDLIEKG--IAD--------IMYEFSNRP---VYCRcgtecvvkvvkdQWFIDYSDPEWKELAH- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 427 adlndELVERgrqLDFHPDFMRVRYENWVRGLKgDWLVSRQRFFGVPFPlWyrvgadgqvDYDAVITPSEDS-------- 498
Cdd:PRK12300 414 -----KALDN---MEIIPEEYRKEFENTIDWLK-DRACARRRGLGTRLP-W---------DEEWIIESLSDStiymayyt 474
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 499 -------LPVDPSTDAPE---------GFTEEQRGEPGGFVGELDIM----DTWatsslspqlacgwlhdddlfartYPM 558
Cdd:PRK12300 475 iahkireYGIKPEQLTPEffdyvflgkGDPEEVSKKTGIPKEILEEMreefLYW-----------------------YPV 531
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 559 DLRPQGQDIIRT----WLFSTVVRADLEFgalpW-RHAGLSGWILdADHKKMSKSKGNVVTPMGLLEKYGSDAVR-YWAA 632
Cdd:PRK12300 532 DWRHSGKDLIPNhltfFIFNHVAIFPEEK----WpRGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRlYLTS 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 633 SARLGLDAAFDEQQMKIGRRLAIKVLN-ASKFALTMGGEGARldldpalvtvDLDRSVLAELAGVVAEATDALASYDHAR 711
Cdd:PRK12300 607 SAELLQDADWREKEVESVRRQLERFYElAKELIEIGGEEELR----------FIDKWLLSRLNRIIKETTEAMESFQTRD 676
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 712 AleVTESFFWTFCD--DYLELVKERayNREGAWDgasaasaraalalVIDTVVRLLAPYLPFVTEEVWSWY-REGSVHTA 788
Cdd:PRK12300 677 A--VQEAFYELLNDlrWYLRRVGEA--NNKVLRE-------------VLEIWIRLLAPFTPHLAEELWHKLgGEGFVSLE 739
|
....
gi 541492522 789 PWPT 792
Cdd:PRK12300 740 KWPE 743
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
686-836 |
1.13e-27 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 109.03 E-value: 1.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 686 DRSVLAELAGVVAEATDALASYDHARALEVTESFFW-TFCDDYLELVKERAYNREGAwdgasaASARAALALVIDTVVRL 764
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWnDLSDWYLELIKDRLYGEEPD------SRAQTTLYEVLETLLRL 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 541492522 765 LAPYLPFVTEEVWswyREGSVHTAPWPTGAPLASAAgDPSVLAAASGALIALRRVKSEAKVSPRTPfLSVVL 836
Cdd:pfam08264 75 LAPFMPFITEELW---QKESIHLAPWPEDAELEEAE-LEEAFELRQEIVQAIRKLRSELKIKKSLP-LEVVI 141
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
42-792 |
7.14e-22 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 102.11 E-value: 7.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 42 PPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQNYFGvrvdatlpydpdfepphvggegksI 121
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLG------------------------I 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 122 KARDQ---KPISRRNfvELCERLTVEDEAQFEALWRYLGLSVDWKQNYQTIGRRARKVAQAAFLRNLARGEAYQaeapGL 198
Cdd:PLN02882 102 KRRDDvlkMGIDKYN--EECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYK----GF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 199 WDVTFQTAVA------QAELESREYPGFYHRIAFHLTDAsaaaeaaragapvEDGADVCVETTRPELLAACVALIAHPD- 271
Cdd:PLN02882 176 KVMPYSTACKtplsnfEAGLNYKDVSDPAVMVSFPIVGD-------------PDNASFVAWTTTPWTLPSNLALCVNPNf 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 272 --------------------------------------------------------DERYKPLFGKTVA-SPVYgveVPV 294
Cdd:PLN02882 243 tyvkvrnkytgkvyivaesrlsalptakpkskkgskpenaaegyevlakvpgsslvGKKYEPLFDYFSEfSDTA---FRV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 295 LAHPAAEKDKGAGIAMCC-TFGDttdiDWWR------------DLGLPLRAilrkDGRIVADTPEWitteagrtafaeiS 361
Cdd:PLN02882 320 VADDYVTDDSGTGVVHCApAFGE----DDYRvclangiiekggNLPVPVDD----DGCFTEKVTDF-------------S 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 362 GKTTFSAREAVVARLRGSGELkgepTKTVRQTN---FFEKGDKPL--EIVTSrqWYIRNggrpwtrpasgADLNDELVER 436
Cdd:PLN02882 379 GRYVKDADKDIIAAIKAKGRL----VKSGSITHsypFCWRSDTPLiyRAVPS--WFVKV-----------EEIKDRLLEN 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 437 GRQLDFHPDFMR-VRYENWVRGLKgDWLVSRQRFFGVPFPLWyrVGADGQvdyDAVITPSEDSLP--------------V 501
Cdd:PLN02882 442 NKQTYWVPDYVKeKRFHNWLENAR-DWAVSRSRFWGTPLPIW--ISDDGE---EVVVIGSIAELEklsgvkvtdlhrhfI 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 502 D----PSTDAPEgFTEEQRGEpggfvgelDIMDTWATSSLSPQlacGWLH----DDDLFARTYPMDLRPQGQDIIRTWLF 573
Cdd:PLN02882 516 DhitiPSSRGPE-FGVLRRVD--------DVFDCWFESGSMPY---AYIHypfeNKELFEKNFPADFVAEGLDQTRGWFY 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 574 STVVRADLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYW--------AASARLGLDAAFDeq 645
Cdd:PLN02882 584 TLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYlinspvvrAEPLRFKEEGVFG-- 661
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 646 qmkIGRRLAIKVLNASKF----ALTMGGEGAR----LDLDPALVTVD-LDRSVLAELAGVVAEATDALASYDHARALEVT 716
Cdd:PLN02882 662 ---VVKDVFLPWYNAYRFlvqnAKRLEVEGGApfvpLDLAKLQNSANvLDRWINSATQSLVKFVREEMGAYRLYTVVPYL 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 717 ESFFWTFCDDYLELVKERAYNREGAWDgasAASARAALALVIDTVVRLLAPYLPFVTEEVWSWYR------EGSVHTAPW 790
Cdd:PLN02882 739 VKFIDNLTNIYVRFNRKRLKGRTGEED---CRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLRkvlpgsEESIHYCSF 815
|
..
gi 541492522 791 PT 792
Cdd:PLN02882 816 PQ 817
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
10-795 |
7.13e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 95.28 E-value: 7.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 10 LEHKWGSAWEAEGTYAF--DRTAAREQVYSIDT-PPPTVSGsLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLP 86
Cdd:PLN02563 85 IEPKWQRYWEENRTFRTpdDVDTSKPKFYVLDMfPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 87 TERrvqnyFGVRVdatlpydpdfepphvggeGKSIKARDQKPISRrnfvelcerltvedeaqFEALWRYLGLSVDWKQNY 166
Cdd:PLN02563 164 AEQ-----YAIET------------------GTHPKITTLKNIAR-----------------FRSQLKSLGFSYDWDREI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 167 QTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDVTFQTAVAQAE----------------------------------- 211
Cdd:PLN02563 204 STTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergghpvirkpmrqwmlkitayadrlled 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 212 LESREYPGFYH-------------RIAFHLTDASAAaeaaragapvEDGADVCVETTRPELLAACVALIAHPDD------ 272
Cdd:PLN02563 284 LDDLDWPESIKemqrnwigrsegaELDFSVLDGEGK----------ERDEKITVYTTRPDTLFGATYLVVAPEHpllssl 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 273 ---------ERYKPL-------------------FGKTVA-SPVYGVEVPVLAHPAAEKDKGAGIAMCCTFGDTTDIDWW 323
Cdd:PLN02563 354 ttaeqkeavEEYVDAasrksdlertelqkektgvFTGSYAiNPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFA 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 324 RDLGLPLRAILR-KDGRivADTPEWITTEAGR-----TAFAEISGKTTFSAREAVVARLRGSGelkgeptktvrqtnffe 397
Cdd:PLN02563 434 QKFDLPIKWVVKpADGN--EDDAEKAYTGEGVivnssSSGLDINGLSSKEAAKKVIEWLEETG----------------- 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 398 kgdkpleivtsrqwyirNGGRpwtrpasgadlndelvergrqldfhpdfmRVRYEnwVRglkgDWLVSRQRFFGVPFPLW 477
Cdd:PLN02563 495 -----------------NGKK-----------------------------KVNYK--LR----DWLFARQRYWGEPIPVV 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 478 YrvgadgQVDYDAVITPSEDSLPVD-PSTDapeGFTEEQRGEP-----------------GGFVGELDIMDTWATSS--- 536
Cdd:PLN02563 523 F------LEDSGEPVPVPESDLPLTlPELD---DFTPTGTGEPplakavswvntvdpssgKPARRETNTMPQWAGSCwyy 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 537 ------------LSPQLACGW--------------LHddDLFARTYPMDLRPQG-------------QDIIRTWLFSTV- 576
Cdd:PLN02563 594 lrfmdpknsnalVDKEKEKYWmpvdlyvggaehavLH--LLYARFWHKVLYDIGvvstkepfqclvnQGMILGEVEYTAf 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 577 -------VRADLEFGALPWRHAGLS---------GWILDADHK--------KMSKSKGNVVTPMGLLEKYGSDAVRYWaa 632
Cdd:PLN02563 672 kdsdgeyVSADTADRLGELQQEKIPeekviksgdSFVLKDDPSirliarahKMSKSRGNVVNPDDVVSEYGADSLRLY-- 749
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 633 sarlgldaafdeqQMKIGRrlaikvLNASKFALTMGGEGARLDLDPAL-VTVDLDRSVLAELAGVVaeATDALASYDHAR 711
Cdd:PLN02563 750 -------------EMFMGP------LRDSKTWSTSGVEGVHRFLGRTWrLVVGAPLPDGSFRDGTV--VTDEEPSLEQLR 808
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 712 AL-----EVTESF----FWTFCDDYLELVkerayNREGAWDgasaasarAALALVIDTVVRLLAPYLPFVTEEVWSWY-R 781
Cdd:PLN02563 809 LLhkciaKVTEEIestrFNTAISAMMEFT-----NAAYKWD--------KVPREAIEPFVLLLSPYAPHLAEELWFRLgH 875
|
970
....*....|....
gi 541492522 782 EGSVHTAPWPTGAP 795
Cdd:PLN02563 876 SNSLAYEPWPEANP 889
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
40-778 |
2.17e-18 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 89.79 E-value: 2.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 40 TPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQNyfgvrvdatlpydpdfepphvggEGK 119
Cdd:COG0143 7 TAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEK-----------------------EGI 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 120 SIKardqkpisrrnfvELCERLTvedeAQFEALWRYLGLSVDwkqNYqtiGR----RARKVAQAAFLRNLARGEayqaea 195
Cdd:COG0143 64 TPQ-------------ELVDRIH----AEFKELFEKLGISFD---NF---IRttspEHKELVQEIFQRLYDNGD------ 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 196 pglwdvtfqtavaqaeLESREYPGFYhriafhltdasaaaeaaragapvedgadvCVEttrpellaacvaliahpdDERY 275
Cdd:COG0143 115 ----------------IYKGEYEGWY-----------------------------CPE------------------CERF 131
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 276 KP---LFGKtvaSPVYGvevpvlahpaAEKDKGAGIAMCCTFGDTTDidwwrdLGLPLRAIlrkDGRivadTPEWITTEa 352
Cdd:COG0143 132 LPdryVEGT---CPKCG----------AEDAYGDQCENCGATLEPTE------LINPRSAI---SGA----PPELREEE- 184
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 353 grtafaeisgkttfsareavvarlrgsgelkgeptktvrqtNFFEKGDK---PLeivtsRQWYIRNGgrpwtrpasgaDL 429
Cdd:COG0143 185 -----------------------------------------HYFFRLSKyqdRL-----LEWIEENP-----------DI 207
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 430 NDElvergrqldfhpdfmrVRYE--NWVR-GLKgDWLVSRqRF-FGVPFPlwyrvGADGQVDY---DAV---ITpsedsl 499
Cdd:COG0143 208 QPE----------------VRNEvlSWLKeGLQ-DLSISR-DFdWGIPVP-----GDPGKVFYvwfDALigyIS------ 258
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 500 pvdpstdAPEGFTEEqRGEPGGFvgeldimDTWatsslspqlacgWLHDDdlfARTYpmdlrpQ--GQDIIRtwlFSTVV 577
Cdd:COG0143 259 -------ATKGYADD-RGLPEDF-------EKY------------WPAPD---TELV------HfiGKDIIR---FHAII 299
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 578 R------ADLEfgaLPWRHAGlSGWILDADhKKMSKSKGNVVTPMGLLEKYGSDAVRYW-AASARLGLDAAFDEQQMKig 650
Cdd:COG0143 300 WpamlmaAGLP---LPKKVFA-HGFLTVEG-EKMSKSRGNVIDPDDLLDRYGPDALRYYlLREVPFGQDGDFSWEDFV-- 372
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 651 RR----LAIKVLN-ASKfALTM-----GGEgarldLDPALVTVDLDRSVLAELAGVVAEATDALASYDHARALEVTesff 720
Cdd:COG0143 373 ARvnsdLANDLGNlASR-TLSMihkyfDGK-----VPEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEI---- 442
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 541492522 721 WTFCDD---YLE------LVKERayNREGAwdgasaasaraalalviDTVVR-----------LLAPYLPFVTEEVWS 778
Cdd:COG0143 443 MALARAankYIDetapwkLAKDE--DPERL-----------------ATVLYtllealrilaiLLKPFLPETAEKILE 501
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
43-201 |
1.07e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 81.91 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 43 PTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTerrvqnyfgvrvdatlpydpdfepphvggEGKSIK 122
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPA-----------------------------ENAAIK 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 123 -ARDQKPISRRNFVELcerltvedEAQFEAlwryLGLSVDWKQNYQTIGRRARKVAQAAFLRNLARGEAYQAEAPGLWDV 201
Cdd:cd00812 60 iGRDPEDWTEYNIKKM--------KEQLKR----MGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCK 127
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
274-630 |
6.88e-15 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 79.63 E-value: 6.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 274 RYKPLFGKTVASPVYGVEV-PVLAHPAAEKDKGAGIAMCC-TFGDTtDIDWWRDLGlplraILRKDGRIVADTPEW---I 348
Cdd:PTZ00427 401 RYKPLFTNFYEKYNFKERAyKILADDFVTDDAGTGIVHCApTYGED-DFRVCKKNG-----VIDPEKNIFIDPLDAngyF 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 349 TTEAgrtafAEISGKTTFSAREAVVARLRGSGELKGEPTkTVRQTNFFEKGDKPLEIVTSRQWYIRNggrpwtrpasgAD 428
Cdd:PTZ00427 475 TNEV-----EEVQNLYIKEADNVIKKKLKNENRLLSNNT-IVHSYPFCWRSDTPLIYRAIPAWFIRV-----------SN 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 429 LNDELVERGRQLDFHPDFMR-VRYENWVRGLKgDWLVSRQRFFGVPFPLWYRVGADGQVDYDAvITPSEDSLPVDPSTDA 507
Cdd:PTZ00427 538 STNELVKNNETTYWIPAHIKeKKFHNWIKDAK-DWCISRNRYWGTPIPIWADEKMETVICVES-IKHLEELSGVKNINDL 615
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 508 PEGFTE--EQRGEPGGFVGEL----DIMDTWATSSLSP--QLACGWLHDDDLFARTYPMDLRPQGQDIIRTWLFSTVVRA 579
Cdd:PTZ00427 616 HRHFIDhiEIKNPKGKTYPKLkripEVFDCWFESGSMPyaKVHYPFSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVIS 695
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 541492522 580 DLEFGALPWRHAGLSGWILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYW 630
Cdd:PTZ00427 696 TLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLY 746
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
409-644 |
1.66e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 72.28 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 409 RQWYIRNGGRPWtrpasgadlNDELVERGRQLDFHPDFMRVRYENWVRglkgdwlVSRQRFFGVPFPlwyrvgadgqvdy 488
Cdd:cd00812 130 DQWFLKYSETEW---------KEKLLKDLEKLDGWPEEVRAMQENWIG-------CSRQRYWGTPIP------------- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 489 davITpsedslpvdpstdapegfteeqrgepggfvgelDIMDTWATSS----------LSPQLACGWLHDD-DLFARTYP 557
Cdd:cd00812 181 ---WT---------------------------------DTMESLSDSTwyyarytdahNLEQPYEGDLEFDrEEFEYWYP 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 558 MDLRPQGQDIIRT----WLFSTVVRADLEFGALPW-RHAGLSGWILdADHKKMSKSKGNVVTPMGLLEKYGSDAVR-YWA 631
Cdd:cd00812 225 VDIYIGGKEHAPNhllySRFNHKALFDEGLVTDEPpKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARlYIL 303
|
250
....*....|...
gi 541492522 632 ASARlgLDAAFDE 644
Cdd:cd00812 304 FAAP--PDADFDW 314
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-169 |
4.72e-12 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 68.41 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 42 PPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQNYFGVRvdatlpydpdfepphvggegksi 121
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGIS----------------------- 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 541492522 122 KARDQKPISRRNFVELCERLTVEDEAQFEALWRYLGLSVDWKQNYQTI 169
Cdd:cd00818 66 GKKDIEKMGIAEFNAKCREFALRYVDEQEEQFQRLGVWVDWENPYKTM 113
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
38-201 |
1.25e-11 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 66.79 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 38 IDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQNyfgvrvdatlpydpdfepphvggE 117
Cdd:cd00814 4 ITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEE-----------------------E 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 118 GKSIKardqkpisrrnfvELCERLTvedeAQFEALWRYLGLSVDwkqNYqtiGR----RARKVAQAAFLRNLARGEAYQA 193
Cdd:cd00814 61 GVTPQ-------------ELCDKYH----EIFKDLFKWLNISFD---YF---IRttspRHKEIVQEFFKKLYENGYIYEG 117
|
....*...
gi 541492522 194 EAPGLWDV 201
Cdd:cd00814 118 EYEGLYCV 125
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
642-792 |
2.38e-11 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 63.34 E-value: 2.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 642 FDEQQMKIGRRLAIKVL-NASKFALT----MGGEGARLDLDPALVTVdLDRSVLAELAGVVAEATDALASYDHARALEVT 716
Cdd:cd07961 1 FSEKGVREVVRKVLLPLwNAYRFFVTyanlDGFDPGKDDDAVASLNV-LDRWILSRLNSLIKEVTEEMEAYDLYTAVRAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 717 ESFF-----WtfcddYLELVKERAYNREGAWDgasAASARAALALVIDTVVRLLAPYLPFVTEEVW------SWYREGSV 785
Cdd:cd07961 80 LEFIdeltnW-----YIRRNRKRFWGEEGDDD---KLAAYATLYEVLLTLSRLMAPFTPFITEEIYqnlrreLGDAPESV 151
|
....*..
gi 541492522 786 HTAPWPT 792
Cdd:cd07961 152 HLLDWPE 158
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
542-714 |
4.35e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 66.75 E-value: 4.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 542 ACGWLHDDD-LFARTYPMDLRPQGQDIIRtwlFSTVV------RADLEfgaLPwRHAGLSGWILdADHKKMSKSKGNVVT 614
Cdd:PRK12267 238 ALGYGSDDDeLFKKFWPADVHLVGKDILR---FHAIYwpimlmALGLP---LP-KKVFAHGWWL-MKDGKMSKSKGNVVD 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 615 PMGLLEKYGSDAVRYW-AASARLGLDAAFDEQQMkIGRrlaikvLNaSKFA----------LTM-----GGEgarldLDP 678
Cdd:PRK12267 310 PEELVDRYGLDALRYYlLREVPFGSDGDFSPEAL-VER------IN-SDLAndlgnllnrtVAMinkyfDGE-----IPA 376
|
170 180 190
....*....|....*....|....*....|....*.
gi 541492522 679 ALVTVDLDRSVLAELAGVVAEATDALASYDHARALE 714
Cdd:PRK12267 377 PGNVTEFDEELIALAEETLKNYEELMEELQFSRALE 412
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
36-198 |
1.44e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 64.52 E-value: 1.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 36 YSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQNyfgvrvdatlpydpdfepphvg 115
Cdd:PRK11893 3 FYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEE---------------------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 116 gEGKSIKardqkpisrrnfvELCERLTvedeAQFEALWRYLGLSVDwkqNY-QTIGRRARKVAQAAFLRNLARGEAYQAE 194
Cdd:PRK11893 61 -AGISPQ-------------ELADRNS----AAFKRLWEALNISYD---DFiRTTDPRHKEAVQEIFQRLLANGDIYLGK 119
|
....
gi 541492522 195 APGL 198
Cdd:PRK11893 120 YEGW 123
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
443-642 |
3.83e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 62.16 E-value: 3.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 443 HPDFMR---VRYE--NWVR-GLKgDWLVSRQRF-FGVPFPLwyrvgADGQVDY---DAVItpsedslpvdpstdapegft 512
Cdd:cd00814 158 NPDFIWpenARNEvlSWLKeGLK-DLSITRDLFdWGIPVPL-----DPGKVIYvwfDALI-------------------- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 513 eeqrgepgGFVGeldimdtwATSSLSPQLACGWLHDDDLFARTYPMdlrpqGQDIIRtwlFSTVVRADLEFGA---LPWR 589
Cdd:cd00814 212 --------GYIS--------ATGYYNEEWGNSWWWKDGWPELVHFI-----GKDIIR---FHAIYWPAMLLGAglpLPTR 267
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 541492522 590 HAGlSGWILDADhKKMSKSKGNVVTPMGLLEKYGSDAVRYW-AASARLGLDAAF 642
Cdd:cd00814 268 IVA-HGYLTVEG-KKMSKSRGNVVDPDDLLERYGADALRYYlLRERPEGKDSDF 319
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
548-715 |
5.02e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 62.98 E-value: 5.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 548 DDDLFARTYPMDLRPQGQDIIRtwlFSTVV------RADLEfgaLPWR---HaglsGWILDaDHKKMSKSKGNVVTPMGL 618
Cdd:PRK11893 245 LAELFNKYWPADVHLIGKDILR---FHAVYwpaflmAAGLP---LPKRvfaH----GFLTL-DGEKMSKSLGNVIDPFDL 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 619 LEKYGSDAVRYWAAS-ARLGLDAAFDEQQMkigrrlaIKVLNASkFALTMG------GEGARLDLDPAL----VTVDLDR 687
Cdd:PRK11893 314 VDEYGVDAVRYFLLReIPFGQDGDFSREAF-------INRINAD-LANDLGnlaqrtLSMIAKNFDGKVpepgALTEADE 385
|
170 180
....*....|....*....|....*...
gi 541492522 688 SVLAELAGVVAEATDALASYDHARALEV 715
Cdd:PRK11893 386 ALLEAAAALLERVRAAMDNLAFDKALEA 413
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
556-809 |
6.76e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 63.16 E-value: 6.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 556 YPMDLRPQGQDIIRTWL-FS----TVVRADLefgalPW-RHAGLSGWILdADHKKMSKSKGNVVTPMGLLEKYGSDAVRY 629
Cdd:PLN02959 670 YPFDLRVSGKDLIQNHLtFAiynhTAIWAEE-----HWpRGFRCNGHLM-LNSEKMSKSTGNFLTLRQAIEEFSADATRF 743
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 630 WAASARLGLDAA---FDEQQMKIGR---RLA-IKVLNASKFALTMGGEgarldldpalvTVDLDRSVLAELAGVVAEATD 702
Cdd:PLN02959 744 ALADAGDGVDDAnfvFETANAAILRltkEIAwMEEVLAAESSLRTGPP-----------STYADRVFENEINIAIAETEK 812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 703 ALASYDHARALEvtESFF--WTFCDDYLELVKERAYNREGAWdgasaasaraalaLVIDTVVRLLAPYLPFVTEEVWS-- 778
Cdd:PLN02959 813 NYEAMMFREALK--SGFYdlQAARDEYRLSCGSGGMNRDLVW-------------RFMDVQTRLITPICPHYAEHVWRei 877
|
250 260 270
....*....|....*....|....*....|.
gi 541492522 779 WYREGSVHTAPWPTGAPLasaagDPSVLAAA 809
Cdd:PLN02959 878 LKKEGFAVTAGWPVAGEP-----DLTLKRAN 903
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
675-819 |
9.86e-10 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 58.69 E-value: 9.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 675 DLDPALVTVD------LDRSVLAELAGVVAEATDALASYDHARALEVTESF-------FwtfcddYLELVKERAYNreGA 741
Cdd:cd07960 29 DFDPAKDAVPyeelleLDRYALHRLNELIKEVREAYENYEFHKVYQALNNFctvdlsaF------YLDIIKDRLYC--DA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 742 WDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWS----WYREGSVHTAPWPTGAPLAsaagDPSVLAAASGALIALR 817
Cdd:cd07960 101 KDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEhlpgEKKEESVFLEDWPELPEEW----KDEELEEKWEKLLALR 176
|
..
gi 541492522 818 RV 819
Cdd:cd07960 177 DE 178
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
36-201 |
1.51e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 60.77 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 36 YSIDTPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTErrvqnyfgvrvdatlpydpdfepphvg 115
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIE--------------------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 116 gegksIKARDQKpISRRnfvELCERLTvedeAQFEALWRYLGLSVDwkqNY-QTIGRRARKVAQAAFLRNLARGEAYQAE 194
Cdd:pfam09334 54 -----LKAEKEG-ITPE---ELVDRYH----EIHREDFKKFNISFD---DYgRTTSERHHELVQEFFLKLYENGYIYEKE 117
|
....*..
gi 541492522 195 APGLWDV 201
Cdd:pfam09334 118 IEQFYCP 124
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
38-213 |
1.08e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.50 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 38 IDTPPPTVSGSLHIGHvfSYThT---DVVARFQRMRGRAVFYPMGWDDNGLPTERrvqnyfgvrvdatlpydpdfepphv 114
Cdd:PRK12267 8 ITTPIYYPNGKPHIGH--AYT-TiaaDALARYKRLQGYDVFFLTGTDEHGQKIQQ------------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 115 ggegkSIKARDQKPIsrrnfvELCERLTvedeAQFEALWRYLGLSVDwkqnyQTIgR----RARKVAQAAFLRNLARGEA 190
Cdd:PRK12267 60 -----AAEKAGKTPQ------EYVDEIS----AGFKELWKKLDISYD-----KFI-RttdeRHKKVVQKIFEKLYEQGDI 118
|
170 180
....*....|....*....|...
gi 541492522 191 YQAEAPGLWDVTFQTAVAQAELE 213
Cdd:PRK12267 119 YKGEYEGWYCVSCETFFTESQLV 141
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
452-635 |
4.39e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 49.98 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 452 ENWVR-GLKgDWLVSRQRFFGVPFPlwyrvGADGQVDYDAVitpsedslpvdpstDAPEGFTeeqrgepgGFVGEldimd 530
Cdd:pfam09334 215 LEWLKeGLK-DRAISRDLDWGIPVP-----GAEGKVFYVWL--------------DAPIGYI--------SATKE----- 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 531 twatsslspqlacgWLHDDDLFARTYPMDLRPQ-----GQDIIRtwlFSTVV-RADLEfgALPWR-----HAglSGWILd 599
Cdd:pfam09334 262 --------------LSGNEEKWKEWWPNDPDTElvhfiGKDIIY---FHTIFwPAMLL--GAGYRlpttvFA--HGYLT- 319
|
170 180 190
....*....|....*....|....*....|....*.
gi 541492522 600 ADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASAR 635
Cdd:pfam09334 320 YEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNR 355
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
588-634 |
4.77e-06 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 50.10 E-value: 4.77e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 541492522 588 WRHAGLsgwiLDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASA 634
Cdd:COG0215 253 WMHNGF----LTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSA 295
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
684-780 |
8.08e-06 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 45.66 E-value: 8.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 684 DLDRSVLAELAGVVAEATDALASYDHARALevTESFF--WTFCDDYLELVKERAyNREGAWdgasaasaraalaLVIDTV 761
Cdd:cd07959 35 FIDRWLLSRLNRLIKETTEAYENMQFREAL--KEGLYelQNDLDWYRERGGAGM-NKDLLR-------------RFIEVW 98
|
90
....*....|....*....
gi 541492522 762 VRLLAPYLPFVTEEVWSWY 780
Cdd:cd07959 99 TRLLAPFAPHLAEEIWHEL 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
556-668 |
4.35e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 47.40 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 556 YPMDLRPQGQDIIR---TWLFSTVVRADLEFGALPWRHAglsgwILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRY-WA 631
Cdd:PLN02224 320 WPASLHLIGKDILRfhaVYWPAMLMSAGLELPKMVFGHG-----FLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYfFL 394
|
90 100 110
....*....|....*....|....*....|....*..
gi 541492522 632 ASARLGLDAAFDEQQMkigrrlaIKVLNAsKFALTMG 668
Cdd:PLN02224 395 REVEFGNDGDYSEDRF-------IKIVNA-HLANTIG 423
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
41-86 |
9.20e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 46.22 E-value: 9.20e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 541492522 41 PPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLP 86
Cdd:PLN02959 52 PYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGMP 97
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
43-88 |
9.41e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 46.30 E-value: 9.41e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 541492522 43 PTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTE 88
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIM 56
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
588-630 |
2.94e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 42.95 E-value: 2.94e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 541492522 588 WRHAGLsgwiLDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYW 630
Cdd:cd00672 162 WLHTGH----LTIDGEKMSKSLGNFITVRDALKKYDPEVLRLA 200
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
40-92 |
6.21e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 40.93 E-value: 6.21e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 541492522 40 TPPPTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPMGWDDNGLPTERRVQ 92
Cdd:cd00802 3 FSGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPAN 55
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
596-630 |
6.46e-04 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 43.26 E-value: 6.46e-04
10 20 30
....*....|....*....|....*....|....*
gi 541492522 596 WILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYW 630
Cdd:PRK00750 272 LFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLF 306
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
453-778 |
7.89e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 43.22 E-value: 7.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 453 NWVR-GLKgDWLVSRQ-RFFGVPFPlwyrvGADGQVDYDAVitpsedslpvdpstDAPEG---FTEE--QRGEPGGFvge 525
Cdd:PRK00133 218 EWLEeGLQ-DWDISRDaPYFGFEIP-----GAPGKVFYVWL--------------DAPIGyisSTKNlcDKRGGLDW--- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 526 ldimDTWatsslspqlacgWLHDDDlfARTYpmdlrpQ--GQDIIRtwlFSTVV-RADLEFG--ALPWR-HAglSGWiLD 599
Cdd:PRK00133 275 ----DEY------------WKKDSD--TELY------HfiGKDIIY---FHTLFwPAMLEGAgyRLPTNvFA--HGF-LT 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 600 ADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAAsARLG-----LDAAFDEQQMKIGRRLAIKVLN----ASKFALT-MGG 669
Cdd:PRK00133 325 VEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLA-AKLPetiddLDFNWEDFQQRVNSELVGKVVNfasrTAGFINKrFDG 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 541492522 670 EgarldldpaLVTVDLDRSVLAELAGVVAEATDALASYDHARAL-EVTE------SFF-----WtfcddylELVKErayn 737
Cdd:PRK00133 404 K---------LPDALADPELLEEFEAAAEKIAEAYEAREFRKALrEIMAladfanKYVddnepW-------KLAKQ---- 463
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 541492522 738 regawDGASAASARAALALVIDTVVRLLAPYLPFVTEEVWS 778
Cdd:PRK00133 464 -----DGERLQAVCSVGLNLFRALAIYLKPVLPELAERAEA 499
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
596-635 |
2.14e-03 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 41.16 E-value: 2.14e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 541492522 596 WILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASAR 635
Cdd:cd00674 267 FIGLKGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRK 306
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
43-78 |
2.31e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 40.25 E-value: 2.31e-03
10 20 30
....*....|....*....|....*....|....*.
gi 541492522 43 PTVSGSLHIGHVFSYTHTDVVARFQRMRGRAVFYPM 78
Cdd:cd00672 28 PTVYDYAHIGHARTYVVFDVLRRYLEDLGYKVRYVQ 63
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
596-635 |
3.34e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 40.71 E-value: 3.34e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 541492522 596 WILDADHKKMSKSKGNVVTPMGLLEKYGSDAVRYWAASAR 635
Cdd:pfam01921 271 LILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRTK 310
|
|
| |
