|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
1-393 |
0e+00 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 654.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 1 MKRFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMM 80
Cdd:PRK10473 1 MSRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 81 ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLF 160
Cdd:PRK10473 81 ASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 161 YTMSAMGIIVGLLSLFILRETRPARlAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRG 240
Cdd:PRK10473 161 YTMAAMGILVLLLSLFILKETRPAR-APAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 241 DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALG 320
Cdd:PRK10473 240 EYAIIMALTAGVSMTVSFSTPFALGIFKPRTLMLTSQVLFLAAGITLALSPSHAVSLFGITLICAGFSVGFGVAMSQALG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549580603 321 PFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVAPNRSVAEHEEIPYQS 393
Cdd:PRK10473 320 PFSLRAGVASSTLGIAQVCGSSLWIWLAAVLGISAWNMLIGILIACSIVSLLLILFVAPGRPVAAHEEIPHHA 392
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
5-375 |
4.83e-84 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 260.97 E-value: 4.83e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 5 LLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLL 84
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 85 CSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMS 164
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 165 AMGIIVGLLSLFILRETRPARLAPRDLSRS-SPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYA 243
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLlRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 244 ITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLA-----HTNTVTLFGLTLICAGFSVGFGVAMSQA 318
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallggLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 549580603 319 LGPFSLRAGVASSTLGIAQVCGSSLWIWLAAIL-GISAMNMLIGILIGCSIVSILLIF 375
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLpNGTALPMGLLILVLGLLALLLLIL 378
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
2-375 |
5.32e-36 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 135.59 E-value: 5.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 2 KRFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMA 81
Cdd:TIGR00710 4 KAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 82 SLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFY 161
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 162 TMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGD 241
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICA-----GFSVGFGVAMS 316
Cdd:TIGR00710 244 FGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMmfvgiGNSMISSIAMA 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 317 QALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAILGISAMNMLIGILIgCSIVSILLIF 375
Cdd:TIGR00710 324 YALEDFPHVAGTASALFGTLRlVLGAIVGYLVSLIHGNTAWPMSLSCLV-LAVVSVLAFY 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-343 |
4.58e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 129.32 E-value: 4.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 2 KRFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMA 81
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 82 SLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFY 161
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 162 TMSAMGIIVGLLSLFILRETRPARLAPrdlsRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGD 241
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARAR----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGP 321
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|...
gi 549580603 322 FSLRA-GVASSTLGIAQVCGSSL 343
Cdd:COG2814 325 APPEArGRASGLYNSAFFLGGPL 347
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
14-183 |
8.72e-31 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 121.17 E-value: 8.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 14 LYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSL 93
Cdd:PRK11102 2 LMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 94 FLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLL 173
Cdd:PRK11102 82 LIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAAL 161
|
170
....*....|
gi 549580603 174 SLFILRETRP 183
Cdd:PRK11102 162 VFFFIPETLP 171
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-375 |
5.96e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.66 E-value: 5.96e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 106 GGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRP-- 183
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPpp 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 184 ARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFA 263
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 264 LGLFKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQAL----GPFSLRA---GVASSTLGIA 336
Cdd:cd17325 259 SDRIGRKPLILI--GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALladiVPPEGRGtamGLFNTAFSLG 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 549580603 337 QVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIF 375
Cdd:cd17325 337 MVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
21-388 |
5.15e-25 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 104.99 E-value: 5.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFL 100
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 101 QGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRE 180
Cdd:PRK11652 106 QGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 181 TRPARLAPRDLSRSSPAAesLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSrgdyaitmaltagvSMVVS--F 258
Cdd:PRK11652 186 TRPADARRTRVLASYRTL--LSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLS--------------SMTVSilF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 259 STPFALGLF---------KPR-TLMLVSQGLFLTAGVTLSLAH----TNTVTLF-GLTLICAGFSVGFGVAMSQALGPFS 323
Cdd:PRK11652 250 ILPIPAAFFgawfagrpnKRFsTLMWQSVICCLLAGLLMWIPGwfgvMNVWTLLvPAALFFFGAGMLFPLATSGAMEPFP 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549580603 324 LRAGVASSTLGIAQVCGSSLWIWLAAILGISAmNMLIGILigCSIVSILLIFSVAPNRSVAEHEE 388
Cdd:PRK11652 330 YLAGTAGALLGGLQNIGSGLAALLSAMLPQTG-QFSLGLL--MTLMGLLILLCWLPLATRMSHQG 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-386 |
8.24e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 101.48 E-value: 8.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 23 LVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQG 102
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 103 VGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSlfilretr 182
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA-------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 183 parlaprdlsrsspaaeslvnRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPF 262
Cdd:cd17321 168 ---------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 263 ALGLFKPRTLMLVsqGLFLTAGVTLSLA---HTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSL---RAGVASSTLGIA 336
Cdd:cd17321 227 LADRFGPRLVLVA--GLLLTAVGLLLLAllgADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVpkeKAGAASGILNTA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 549580603 337 QVcgsslwiwLAAILGISAMNMLIGILIGCSIVSILLIFSVAPNRSVAEH 386
Cdd:cd17321 305 RQ--------LGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAFAA 346
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-381 |
2.73e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.94 E-value: 2.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 3 RFLLCSFVLVLLYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMM 80
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSvaAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 81 ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLF 160
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 161 YTMSAMGIIVGLLSLFILretrparlaprdlsrsspaaeslvnrffvsrLAITTLSVSVILTFVNASPVLLMEVMGFSRG 240
Cdd:COG2271 168 LILGLPGLLLALLRFWLL-------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 241 DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALG 320
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549580603 321 PFSLRAGVASSTLGIAQVCGSSLWIWLAAILGI----SAMNMLIGILIGCSIVSILLIFSVAPNR 381
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYlldaTGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-345 |
1.13e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 97.87 E-value: 1.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPR-IAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSR 87
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 88 ASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMG 167
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 168 IIVGLLSLFILRETRPARLAPR-DLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITM 246
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAeEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 247 ALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSL-AHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLR 325
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|
gi 549580603 326 AGVASSTLGIAQVCGSSLWI 345
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGA 341
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
2-373 |
1.07e-21 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 95.78 E-value: 1.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 2 KRFLLCSFVLVLLYPA---GIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVF 78
Cdd:PRK15402 9 RQALLFPLCLVLFEFAtyiANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 79 MMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQS 158
Cdd:PRK15402 89 ILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 159 LFYTMSAmgiiVGLLSLFILRETRP--ARLAPRDLSRSSPAAES---LVNRFFVS-RLAITTLSVSvILTFVNASPVLLM 232
Cdd:PRK15402 169 MFVLFAA----LAALSFFGLWRAMPetAGRVGEKLSLKELGRDYklvLKNRRFVAgALALGLVSLP-LLAWIALSPVILI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 233 EVMGFSRGDYA-----ITMALTAGVSMVVSFSTPFALglfkPRTLML----VSQGLFLTAGVTLSLAHTNTVTLFGLTLI 303
Cdd:PRK15402 244 SGEQLSSYEYGllqvpVFGALIAGNLTLARLTSRRPL----RSLIRMglwpMVAGLLLAALATVISSHAYLWLTAGLSLY 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 304 CAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILL 373
Cdd:PRK15402 320 AFGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLL 389
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-284 |
2.27e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 93.34 E-value: 2.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 2 KRFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMA 81
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 82 SLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFY 161
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 162 TMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGD 241
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 549580603 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAG 284
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
20-363 |
4.30e-20 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 91.04 E-value: 4.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 20 DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRF 99
Cdd:PRK15403 33 DLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 100 LQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILR 179
Cdd:PRK15403 113 IQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 180 ETRPARLAP-RDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITM-----ALTAGVS 253
Cdd:PRK15403 193 ETVKRGAVPfSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAWTQvpvfgAVIVANA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 254 MVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSTL 333
Cdd:PRK15403 273 IVARFVKDPTEPRFIWRAVPIQLVGLALLIVGNLLWPHVWLWSVLGTSLYAFGIGLIFPTLFRFTLFSNNLPKGTVSASL 352
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 549580603 334 GIAQVCGSSL------WIW----------LAAILGISAMNMLIGIL 363
Cdd:PRK15403 353 NMVILMVMAVsveigrWLWfnggrlpfhlLAVVAGVIVVFTLAGLL 398
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
24-351 |
1.87e-19 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 88.79 E-value: 1.87e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGV 103
Cdd:cd17503 17 VALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 104 GAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFIlretrp 183
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 184 arlaprDLSrsspaaeSLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFA 263
Cdd:cd17503 171 ------DLR-------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 264 LGLFKPRTLMLVSQGLFLTAGVTLSLAHTNT-VTLFGLTLICAGFSVGFGVAMSQALGPFSL---RAGVASSTLGIAQVC 339
Cdd:cd17503 238 LDKFGPRLLLLAGLLLLALGTLLLAFLTPDTsLWLIILPLFIRGLGMGLVFMPLNTLALNSLppeQIGDATALFNTIRQL 317
|
330
....*....|..
gi 549580603 340 GSSLWIWLAAIL 351
Cdd:cd17503 318 GGSIGTALLATL 329
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-336 |
1.60e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.47 E-value: 1.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 3 RFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMAS 82
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 83 LLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYT 162
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 163 MSAMGIIVGLLSLFILRETrPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDY 242
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDP-PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 243 AITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSqGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPF 322
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV-FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330
....*....|....
gi 549580603 323 SLRAGVASSTLGIA 336
Cdd:COG2223 323 IFPTKNAGAVYGLV 336
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
19-192 |
6.46e-18 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 84.56 E-value: 6.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 19 IDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGR 98
Cdd:PRK11043 22 TDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 99 FLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFIL 178
Cdd:PRK11043 102 FVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLK 181
|
170
....*....|....
gi 549580603 179 RETRPARLAPRDLS 192
Cdd:PRK11043 182 PSKKARKQSQDALT 195
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-377 |
6.95e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.16 E-value: 6.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRA 88
Cdd:cd17474 5 FFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 89 SEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLrFPWQSLFYTMSAMGI 168
Cdd:cd17474 85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 169 IVGLLSLFILRETRPARLAPRDLSRSSPAAeSLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMAL 248
Cdd:cd17474 164 VAFLAILFLLPEPKEKAKSSSATKLRDLKK-ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 249 TAGVSMVVSFSTPFALGL-FKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFglTLICAGFSVGFGV------AMSQALGP 321
Cdd:cd17474 243 WSVLLALGSLFVGRLLKKrFGARRILVI--GLLLYALSLLLLGFVPSLALL--LIAIVLFGLGLGLnlplltTLVTELAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 549580603 322 FSLRaGVASSTLGIAQVCGSSLWIWLAAIL-GISAMNMLIGILIGCSIVSILLIFSV 377
Cdd:cd17474 319 EEER-GTASSLYNFVRFLGQAVGPLLFGLLlEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-375 |
1.41e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.63 E-value: 1.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRA 88
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 89 SEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLR--FPWQSLFYTMSAM 166
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 167 GIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSV----SVILTFVNASPVLLMEVMGFSRGDY 242
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIflvnLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 243 AITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSqGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPF 322
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI-GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 549580603 323 SLRAGVASSTLGIAQVCGSSLWIWLAAILGISAM-----NMLIGILIGCSIVSILLIF 375
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAatfglTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-364 |
2.64e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 82.60 E-value: 2.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 106 GGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPAR 185
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 186 LAPRDLSRSSPAAesLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALG 265
Cdd:cd17324 182 PGSLGLLSSLLLL--LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 266 LFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSL-- 343
Cdd:cd17324 260 RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALga 339
|
330 340
....*....|....*....|....*....
gi 549580603 344 --------WIWLAAILGISAMNMLIGILI 364
Cdd:cd17324 340 algglvldHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
17-364 |
1.97e-16 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 79.53 E-value: 1.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 17 AGIDMYLVG--LPRIAADLNASEaQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLF 94
Cdd:cd17502 8 AALDQTIVAtaLPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTML 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 95 LSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYtmsaMGIIVGLLS 174
Cdd:cd17502 87 IVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY----INLPIGGLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 175 LFILRetrparlaprdlsrsSPAAESLVNrFFVSrlaittlsvSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSM 254
Cdd:cd17502 163 LALLR---------------TILLSSIFG-FLFG---------GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 255 VVSFSTPFALGLFKPRTLMLVSQGLFLTAG---VTLSLAHTNTVTLFGLTLICaGFSVGFG-----VAMSQALGPFSLRA 326
Cdd:cd17502 218 IGSIISGALISKTGRYKPLIVIGTILMSVGaglLTTLTLDTSKWLLIGYLILL-GLGLGIGfqqplVAVQNAVPPADVGV 296
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 549580603 327 GVASSTLG--IAQVCGSSLWIWLAAILGISAMNMLIGILI 364
Cdd:cd17502 297 ATATNTFFrsLGGTLGVAITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-369 |
3.32e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.18 E-value: 3.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRA 88
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 89 SEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGI 168
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 169 IVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVnaspVLLMEVMGFSrgDYAITMAL 248
Cdd:cd17489 162 LALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL----PLYAAERGIS--NAGLFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 249 TAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGF--GVAMSQALGPFSLRa 326
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFpaLQALAVDLVPPHRR- 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 549580603 327 GVASSTLGIAQ----VCGSSLWIWLAAILGISAMNMLIGILIGCSIV 369
Cdd:cd17489 315 GAANGTFFIFFdlgiGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-384 |
9.08e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.97 E-value: 9.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 1 MKRFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMM 80
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 81 ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDtLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLR---FPWQ 157
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 158 SLFYTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPaAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGF 237
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL-KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 238 SRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQ 317
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549580603 318 ALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILG-ISAMNMLIGILIGCSIVSILLIFSVAPNRSVA 384
Cdd:COG0738 324 ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
44-181 |
1.92e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 72.68 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 44 FSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEH 123
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 549580603 124 RRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRET 181
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-190 |
5.55e-15 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 76.26 E-value: 5.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGV 103
Cdd:TIGR00711 23 VAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 104 GAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRP 183
Cdd:TIGR00711 103 GGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKP 182
|
....*..
gi 549580603 184 ARLAPRD 190
Cdd:TIGR00711 183 AASENFD 189
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
4-180 |
1.70e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 74.15 E-value: 1.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 4 FLLCSFvLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASL 83
Cdd:cd17323 1 VFIISF-LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 84 LCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTM 163
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170
....*....|....*..
gi 549580603 164 SAMGIIVGLLSLFILRE 180
Cdd:cd17323 160 AIISGFCLILIFLFLPI 176
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
56-375 |
2.05e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 2.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 56 LFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGI 135
Cdd:cd17473 53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 136 TCIVPVLAPVVGHLImLRFPWQSLFYTMsAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVsrLAITTL 215
Cdd:cd17473 133 MSLGGVVFLLLGGAL-AEIGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPI--YFLAFL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 216 SVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTV 295
Cdd:cd17473 209 AMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 296 TLFGLTLICAGFSVGFGVAMSQALG--PFSLRA---GVASSTLGIAQVCGSSLWIWLAAIL-GISAMNMLIGILigCSIV 369
Cdd:cd17473 289 VLLGAILAGLGFGLLLPTLNSWAMSlvPPELRGramGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVL--ALVL 366
|
....*.
gi 549580603 370 SILLIF 375
Cdd:cd17473 367 AIVLLL 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-316 |
5.06e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.53 E-value: 5.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFL 100
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 101 QGVGaGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFIlre 180
Cdd:cd17504 94 QGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 181 trparlAPRDLSRSSPAAESLVnrFFVSRLAITTLSVSVILTFVNASPVLLmevmGFSRGDYAITMALTAGVSMVVSFST 260
Cdd:cd17504 170 ------DLRLLRRRNVLLANIT--ALLAGFGMFMVFQLLPQLLQLPTPTGF----GLGITEAGLLLLPGALVMLIAGPLA 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 549580603 261 PFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLIcagFSVGFGVAMS 316
Cdd:cd17504 238 GRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL---IGIGLGLAFA 290
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-323 |
3.60e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 67.33 E-value: 3.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFL 100
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 101 QGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFP----WQSLFYTmsamGIIVGLLSLF 176
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFLL----GALPALLVLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 177 ILRE-TRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNAS--------PVLLMEVMGFSRGDYAITMA 247
Cdd:cd17371 173 IRRFvKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyygittwlPSYLTGERGLSFEGSAGYLV 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 549580603 248 LTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNtvtlFGLTLIcAGFSVGFGVAmsqalGPFS 323
Cdd:cd17371 253 VTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLS----PTLILI-LGFPLGFFAS-----GPFS 318
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-321 |
5.20e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 66.61 E-value: 5.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 2 KRFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMA 81
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 82 SLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFY 161
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 162 TMSAMGIIVGLLSLFILRET------------------------RPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSV 217
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLPESidflvskrpetvrrivnaiapqmqAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 218 -------SVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMlvsqGLFLTAGVTLSLA 290
Cdd:TIGR00895 256 wllyfmlLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA----LLLLLGAVFAVLV 331
|
330 340 350
....*....|....*....|....*....|...
gi 549580603 291 HT--NTVTLFGLTLICAGFSVGFGVAMSQALGP 321
Cdd:TIGR00895 332 GStlFSPTLLLLLGAIAGFFVNGGQSGLYALMA 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-377 |
7.91e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.09 E-value: 7.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 32 DLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVV 111
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 112 AFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFP----WQSLFYTMSAMGIIVGLLSLFILRETrparla 187
Cdd:cd17316 110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLALLLRRRTLLLI------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 188 prdlsrsspaaeslvnrffvsrlAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLF 267
Cdd:cd17316 184 -----------------------LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 268 KPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCG---SSLW 344
Cdd:cd17316 241 GRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGrlgGGGA 320
|
330 340 350
....*....|....*....|....*....|...
gi 549580603 345 IWLAAILGISAMNMLIGILIGCSIVSILLIFSV 377
Cdd:cd17316 321 PPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
6-215 |
1.09e-11 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 65.75 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 6 LCSFVLVLlypAGIDMYLVGL--PRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASL 83
Cdd:PRK11551 19 LCFLVALL---EGLDLQSAGVaaPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 84 LCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLngiTCIVP---VLAPVVGHLIMLRFPWQSLF 160
Cdd:PRK11551 96 ATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM---YCGVPfggALASVIGVLAAGDAAWRHIF 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 549580603 161 YTMSAMGIIVGLLSLFILRETRparlAPRDLSRSSPAAESLVNRFFVSRLAITTL 215
Cdd:PRK11551 173 YVGGVGPLLLVPLLMRWLPESR----AFAQAAGAGKQRAPVLRALFGEGRATATL 223
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
42-375 |
4.74e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 63.77 E-value: 4.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 42 IAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCyvVAFAILRDTLD 121
Cdd:cd17472 36 LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADLTR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 122 EHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARLApRDLSRSSPAAESL 201
Cdd:cd17472 114 EENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQI-SEKEKKKLKKLLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 202 VNRFFVSRLAITTLSVSVILTFVnASPVLLMEVmGFSRGD----YAITMaLTAGVSMVvsFSTPFALGLFKPRTLMLVSQ 277
Cdd:cd17472 193 NKRLLRLDFSIFILHFVLMAFFY-ILPLLLTQL-GGGKGQlwkvYLPAI-LIGFILMV--PFVIYAEKKGKMKQVFVSSI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 278 GLFLTAGVTLSLAHTNTVTLFGLTLIcagFSVGFGV------AMSQALGPFSLRA---GVASSTLGIAQVCGSSLWIWLA 348
Cdd:cd17472 268 LLIAVGFLLLLFAATSLWLLIIGLII---FFIGFNLleallpSLVSKIAPKEYRGtamGIYNTSQFLGSFLGGALGGLLW 344
|
330 340
....*....|....*....|....*..
gi 549580603 349 AILGISAMNMLIGILIGCSIVSILLIF 375
Cdd:cd17472 345 GLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
9-376 |
4.98e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.37 E-value: 4.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDM---YLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLC 85
Cdd:cd17330 2 FLVVFLDALGFGIvfpVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 86 SRASEGSLFLSGRFLQGVGaGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSA 165
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 166 MGIIVGLLSLFILRetrparlaprdlsrsspaaeslvnrfFVSRLAITTLSVSVILTFVNAS-PVLLMEVMGFSRGDYAI 244
Cdd:cd17330 161 LALLNLVLVLFFLP--------------------------PLRRLLLVYFLIALAFAGLESVfSLFLKDRFGFSPSQIGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 245 TMALTAGVSMVVSFS-TPFALGLFKPRTLMLVSQGLFLTAGVTLSLAhtNTVTLFGLTLICAGFSVGFGVAMSQALGPFS 323
Cdd:cd17330 215 LLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 549580603 324 LRAGVASSTLGIAQVCGSSLWIwLAAILGISAMNMLIG---ILIGCSIVSILLIFS 376
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARI-IGPLLAGPLYSFLGPgvpFLLAAGLLLIALFLL 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-364 |
9.96e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 9.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGV 103
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 104 GAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILREtrp 183
Cdd:cd17319 104 AEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ--- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 184 arlaprdlsrsspaaeslvnrffVSRLAITTLSVSVILTFVNA-SPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPF 262
Cdd:cd17319 181 -----------------------VWGLALGYFGINYALYGLLTwLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 263 ALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLIC-AGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGs 341
Cdd:cd17319 238 LSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSlAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGG- 316
|
330 340
....*....|....*....|...
gi 549580603 342 slwiWLAAILGisamNMLIGILI 364
Cdd:cd17319 317 ----NLGGFVA----PLLIGYLV 331
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
26-343 |
2.46e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 2.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 106 GGCYVVAFAILRDTLDeHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPAR 185
Cdd:COG2807 121 AVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 186 LAprdlSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALG 265
Cdd:COG2807 200 AA----APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549580603 266 LFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSlRAGVASSTLGIAQVCGSSL 343
Cdd:COG2807 276 RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR-TPAEAAALSGMAQSVGYLL 352
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
42-375 |
5.13e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 5.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 42 IAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLD 121
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 122 EHRRAKVLSLLNGITCIVPVLAPVVGhLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESL 201
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 202 VNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFL 281
Cdd:cd17329 198 RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 282 TAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQA--LGPFSLRA---GVASSTLGIAQVCGSSLWIWLAAILGISAM 356
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVaaLAPPDKRGsymGFYALAWGLGRAIGPLVGGLLLDLLGPGLP 357
|
330
....*....|....*....
gi 549580603 357 NMLIGILIGCSIVSILLIF 375
Cdd:cd17329 358 WLILAALGLIAAALLLGLQ 376
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
5-181 |
3.50e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.98 E-value: 3.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 5 LLCSFVLVLlypAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMAS 82
Cdd:cd17365 2 ALCFLIIVL---DGFDLAVMGfvAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 83 LLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYT 162
Cdd:cd17365 79 LLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170
....*....|....*....
gi 549580603 163 msamGIIVGLLSLFILRET 181
Cdd:cd17365 159 ----GGVPPLILLPLLRGT 173
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-374 |
5.39e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.24 E-value: 5.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIV-----GALVFMMASLLCSRASEGSLFL 95
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 96 SGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTmSAMGIIVGLLSL 175
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI-NALSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 176 FILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNA----SPVLLMEVMGFSRGDYAITMALTAG 251
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAltvlLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 252 VSMVVSFSTPFALGLFKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQAL----GPFSLRA- 326
Cdd:cd06173 256 GALLGALLLGRLSKRRRRGRLLLI--GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlqlrVPDELRGr 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 549580603 327 --GVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLI 374
Cdd:cd06173 334 vfSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-319 |
7.84e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.90 E-value: 7.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 29 IAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASE-GSLFLSGRFLQGVGAGG 107
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 108 CYVVAFAILRDTLDEHRRAKVLSLL-NGITCIVPVLAPVVGHLIMlRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARL 186
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILtAGGGLGSLVFLPLGAALIE-AFGWRTALLVLALLALLVLVPVLLLLRRRPADLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 187 APRDLSRSSPAAESLVNRFFVSR----LAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPF 262
Cdd:cd17355 188 LRAYDDASPASPGSTLKEALRSAsfwlLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGW 267
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 549580603 263 ALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFgLTLICAGFSVGFGVAMSQAL 319
Cdd:cd17355 268 LGDRYSPRRLLAASYALRALGLALLLLLPFPPLALL-LFAALFGLGWGATVPLTAAL 323
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
42-181 |
1.00e-08 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 56.43 E-value: 1.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 42 IAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLD 121
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 122 EHRRAKVLSLLNGITCIVPVLAPVVGHLIMlrfPWQSLFYTMSAMGIIVGLLSLFILRET 181
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLWWLPRRT 165
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-202 |
1.47e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.09 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:cd17328 22 LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 106 GGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLI-MLRFPWQSLFYTMSAMGIIVGLLSLFILREtrPA 184
Cdd:cd17328 102 ASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLFVRE--PP 179
|
170
....*....|....*...
gi 549580603 185 RLAPRDLSRSSPAAESLV 202
Cdd:cd17328 180 RGAAEGGVMAKSTATSFL 197
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
5-169 |
3.31e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 54.87 E-value: 3.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 5 LLCSFVLVLLYPAGIDMYLVGLPrIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLL 84
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 85 ---CSRASEGSLFLSgRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFY 161
Cdd:cd17380 81 tplLAYSSLPLLILS-RILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159
|
....*...
gi 549580603 162 TMSAMGII 169
Cdd:cd17380 160 FFGLLGLL 167
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-182 |
4.42e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 4.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 3 RFLLCSFVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIAD--QSGRKPVAIVGALVFMM 80
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 81 ASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLF 160
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|..
gi 549580603 161 YTMSAMGIIVGLLSLFILRETR 182
Cdd:COG2271 341 LLLAALALLAALLALLLLRETR 362
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
13-179 |
8.04e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 53.81 E-value: 8.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGS 92
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 93 LFLSGRFLQGVGAGGCYVVAFAILRDTLDEH-RRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVG 171
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNAMALLGRTYPPGpRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVA 167
|
....*...
gi 549580603 172 LLSLFILR 179
Cdd:cd17476 168 VAAIFWTS 175
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
26-371 |
3.06e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.88 E-value: 3.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 106 GGCYvVAFAILRDTLDEHRRAKVLSLLNGITCIVPVL-APVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPA 184
Cdd:cd17393 102 GALD-VAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAgALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 185 RLAPRDLSRSSPaaeslvnRFFVSRLAITTLSVSVILTFV------NASPVLLMEVMGFSRGDYAITMALTAGVSMVVSF 258
Cdd:cd17393 181 AAEDRPDGAGKP-------GFLLPNRLLLLLGLLALAAALaegaaaDWSALYLRDVLGASAALAALGYAVFSLAMTVGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 259 STPFALGLFKPRTLMLVSqGLFLTAGVTLSL-AHTNTVTLFGLTLICAGFSVGFGVAMS----QALGPFSLRAGVASSTL 333
Cdd:cd17393 254 FGDRLVDRFGDVAVLRAG-ALLAALGLLLALlAPSVWVALAGFALMGLGLSVVVPLAFSaagaLPGLAAGIAVARVATLG 332
|
330 340 350
....*....|....*....|....*....|....*...
gi 549580603 334 GIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSI 371
Cdd:cd17393 333 YLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLA 370
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
9-156 |
7.57e-07 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 51.13 E-value: 7.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVL-LYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLC 85
Cdd:TIGR01299 170 FVLGLaLMADGVEVFVVGfvLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFS 249
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549580603 86 SRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPW 156
Cdd:TIGR01299 250 SFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-177 |
1.03e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 3 RFLLCSFVLVLLYPAGIDMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMA 81
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 82 SLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFY 161
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 549580603 162 TMSAMGIIVGLLSLFI 177
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
67-351 |
1.11e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 67 RKPVAIVGALVFMMASLLCSRASEGS------LFLSGRFLQGVGAGGCYVVAFAILRD-TLDEHRRAKVLSLLNGITCIV 139
Cdd:COG2211 80 RRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 140 PVLAPVVGHLIMLRFP------WQSLFYTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSspAAESLVNRFFVSRLAIT 213
Cdd:COG2211 160 GLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES--LKALLKNRPFLLLLLAY 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 214 TLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTN 293
Cdd:COG2211 238 LLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPG 317
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549580603 294 TVTLFGLTLICAGFSVGFGVAMSQALGPFSL----------RAGVASSTLGIAQVCGSSLWIWLAAIL 351
Cdd:COG2211 318 NLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgrrREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-377 |
1.13e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGV 103
Cdd:cd17333 17 ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 104 GAGGCYVVAFAILRdTLDEHRRAKVLSLLNGITCIVPVLAPV-VGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFIL-RET 181
Cdd:cd17333 97 GAGILDTGANTFVG-ALFEESSATRLNVLHGFFGLGALIGPLiATSLLTSELSWSWAYLIIGLIYLLLAILILLTLfPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 182 RPARLAPRDLSRSSPAAESLVNRFFVSRLAITT-LSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFST 260
Cdd:cd17333 176 PSARNPQQSVGAFSASASRLLRNPSIILGALALfLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 261 PFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCG 340
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIG 335
|
330 340 350
....*....|....*....|....*....|....*..
gi 549580603 341 SSLWIWLAAILGiSAMNMLIGILIGCSIVSILLIFSV 377
Cdd:cd17333 336 GAIIPFIMGFIA-EAVGIQTAMLLITILYAIIFVLAL 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
35-177 |
1.27e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.40 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 35 ASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFA 114
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549580603 115 ILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMlrfPWQSLFYTMSAMGIIVGLLSLFI 177
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
32-372 |
1.54e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 32 DLNASEAQLHIAFSVY-LAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEG-SLFLSGRFLQGVGAgGCY 109
Cdd:cd17471 26 ELGASPLQIGIFMTLSaLSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYwVLLLVGVVLLSLGA-AAF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 110 VVAFAILRDTLDEHRR---AKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARL 186
Cdd:cd17471 105 PQLFALAREYADRSSGrdaTLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 187 APrdlSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGL 266
Cdd:cd17471 185 KA---TPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 267 FKPRTLMLVSqGLFLTAGVTLSLAHTNTVTLFGLTLICA---GFSVGFGVAMSQALGPfsLRAGVASS----TLGIAQVC 339
Cdd:cd17471 262 FGKRRLLLAG-FLAGVLFYLGLALATSLWQLIALQLLNAifiGITAGLGISYFQDLMP--GQPGLATTlysnASRIGSLL 338
|
330 340 350
....*....|....*....|....*....|...
gi 549580603 340 GSSLWIWLAAILGISAMNMLIGILIGCSIVSIL 372
Cdd:cd17471 339 GGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
24-186 |
2.43e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.55 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 24 VGLPRIAADLNASEAQLHIAfSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGV 103
Cdd:cd06179 19 AVLPFIVADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 104 GAGGCYVVAFAILrDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFP--WQSLFYTMSAMGIIVGLLSLFILRET 181
Cdd:cd06179 98 GAGTQGLGAAVAS-ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFNALALILLFFFYHPP 176
|
....*
gi 549580603 182 RPARL 186
Cdd:cd06179 177 PRPQL 181
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
1-160 |
2.82e-06 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 49.34 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 1 MKRFLLCSFVLVLLY-PAGIDMYL--VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALV 77
Cdd:PRK14995 1 MFRQWLTLVIIVLVYiPVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 78 FMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDT-LDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPW 156
Cdd:PRK14995 81 FGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
|
....
gi 549580603 157 QSLF 160
Cdd:PRK14995 161 GSVF 164
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-377 |
3.90e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.42 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGV 103
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 104 GAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILREtRP 183
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD-SP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 184 ARLAPRdlsrsspaaeSLVNRF-FVSRLAITTLsvsviltfvnaSPVLLMEVMGFSR--GDYAITMALTAGV--SMVVSF 258
Cdd:cd17312 183 PYVWVL----------SLAYAFvYIVRYACLDW-----------GPLYLYEVKGYSLidAGWFSSLYEVGGIagTILAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 259 STPFALGlfKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVG-----FGVAMSQALGPfSLRAGVASSTL 333
Cdd:cd17312 242 LSDKLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGgpinlIGGAAAQDIGR-KEAAGTATGFV 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 549580603 334 GIAQVCGSSLWIWLAAIL----GISAMNMligILIGCSIVSILLIFSV 377
Cdd:cd17312 319 GLFGYLGASLAGLPLGYIidhyGWSTVFY---FLISAALLSVLLLLSL 363
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
26-379 |
4.05e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 48.33 E-value: 4.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 106 GGCYVVAFAILRDTLDEHRRAKVLSLLN-----GITCIVPV---LAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFI 177
Cdd:cd17359 104 GGASALVPMYIAEVAPAEIRGRLVSLNQlmivfGQLLAYIVnylIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 178 lretrparlaprdlsRSSPaaeslvnRFFVS---RLAITTLSVSVI--LTFVNA----SPVLLMEVmGFSRGDYAITMAL 248
Cdd:cd17359 184 ---------------PESP-------RWLVSkgkPILIIGIGLAIFqqFVGINVifyyGPEIFQNA-GFSENAALLQTIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 249 TAGVSMVVSFSTPFALGLFKPRTLMLVSQ-----GLFLTAGVTLSLAHTNT---VTLFGLTLICAGFSVGFGVAMSQALG 320
Cdd:cd17359 241 IGVVNVIFTIIAILLVDKVGRKPLLLIGSigmaiSLLLIGTAFYFAPGSQAsgiVALVLILLFVAFFAMSWGPVTWVLLS 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549580603 321 ---PFSLRA---GVASSTLGIAQVCGSSLWIWLAAILGISAmnmLIGILIGCSIVSILLIFSVAP 379
Cdd:cd17359 321 eifPNRIRGlamGIAVFFLWIANFLVSLTFPILLAAFGLAF---TFLIFAVICVLAFLFVWKFVP 382
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
39-177 |
4.28e-06 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 48.24 E-value: 4.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 39 QLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRD 118
Cdd:cd17377 40 KVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 549580603 119 TLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMlrfPWQSLFYTMSAMGIIVGLLSLFI 177
Cdd:cd17377 120 CVGKSYWALAGSLGGLFFAVGIAQYALLGYFIR---SWRTLAVVVNLQGTLVFLLSLFI 175
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
9-156 |
5.41e-06 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 48.38 E-value: 5.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVL-LYPAGIDMYLVG--LPRIAADLNASEAQL-HIAFSVYLAGMATAMLFAGkIADQSGRKPVAIVGALVFMMASLL 84
Cdd:cd17438 2 FVLGLaLMADGVEVFVVGfvLPSAEKDMCLSSSNKgMLGLIVYLGMMAGAFIWGG-LADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549580603 85 CSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPW 156
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGW 152
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
31-112 |
1.16e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 47.27 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 31 ADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGS---LFLSGRFLQGVGAGG 107
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGG 118
|
....*
gi 549580603 108 CYVVA 112
Cdd:pfam00083 119 ASVLA 123
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
9-156 |
2.25e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 46.44 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVL-LYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLC 85
Cdd:cd17440 2 FVLGMaLMADGVEVFVVGfvLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549580603 86 SRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPW 156
Cdd:cd17440 82 SFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
9-156 |
3.63e-05 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 45.79 E-value: 3.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVL-LYPAGIDMYLVG--LPRIAADLNASEA-QLHIAFSVYLAGMATAMLFAGkIADQSGRKPVAIVGALVFMMASLL 84
Cdd:cd17439 2 FVLGLaLMADGVEVFVVGfvLPSAEKDMCLSDSnKGMLGLIVYLGMMVGAFLWGG-LADRIGRRQCLLISLSVNSVFAFF 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549580603 85 CSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPW 156
Cdd:cd17439 81 SSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
26-173 |
1.34e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSG-RFLQGVG 104
Cdd:cd17477 211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVlLFLWGGA 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549580603 105 AGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLL 173
Cdd:cd17477 291 AGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
67-374 |
1.74e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 67 RKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGgcYVVAFAILRDTL-DEHRRAKVLSLLNGITCIVPVLAPV 145
Cdd:cd17490 61 RKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAA--TWVSFTVLYASYfPPDEAAKAMGLINLVNNLGQLIAFL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 146 VGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARLAPRDLSRsspAAESLVNR--FFVSRLAITT--LSVSVIL 221
Cdd:cd17490 139 IGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKE---LLSVLKDKklLFFSLLAILQqmITFSTTF 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 222 TFVNaspvLLMEVMGFSRGDYAITMALTAGVSMVVS-FSTPFALGLFKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGL 300
Cdd:cd17490 216 GFTP----LIAKQLGASSFQLGLLSIIYLLPNALASlLSGTLFYKKLGERNTIII--GFLLLGAYCFLIPFAPNLTLLYL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 301 TLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQV---CGSSLWIWLAAIL----GISAMNMLIGIL-IGCSIVSIL 372
Cdd:cd17490 290 LQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAiyaLGMFLGPVLVGIIseafGLQTGFFVIGVIaLLAAILSLA 369
|
..
gi 549580603 373 LI 374
Cdd:cd17490 370 YY 371
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
9-132 |
2.65e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 42.86 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVL-LYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLC 85
Cdd:cd17363 2 FVLGLaLMADGVEVFVVGfvLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLS 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 549580603 86 SRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLL 132
Cdd:cd17363 82 SFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWL 128
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
27-181 |
3.25e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 42.52 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 27 PRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAG 106
Cdd:cd17372 23 PAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549580603 107 GCYVVAfAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRET 181
Cdd:cd17372 103 GGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTT 176
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
9-220 |
5.70e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.85 E-value: 5.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMA-TAMLFA---GKIADQSGRKPVAIVGALVFMMASLL 84
Cdd:cd17388 5 LVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYAlMQFIFApilGALSDRFGRRPVLLLSLAGAALDYLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 85 CSRASEGSLFLSGRFLQGVgAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHL---IMLRFPwqslFY 161
Cdd:cd17388 85 MAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLlgeISPRAP----FL 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 549580603 162 TMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVI 220
Cdd:cd17388 160 VAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLI 218
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
45-312 |
6.67e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 41.47 E-value: 6.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 45 SVYLAGMaTAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHR 124
Cdd:cd17361 59 SLYLAGL-VASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 125 RAKVLSLLNGITCIVPVLAPVVGHLI--MLRFPWQSLFYTMSAMGIIVGLLSLFIlretrparlaprdlsRSSPAAESLV 202
Cdd:cd17361 138 RGALNIGFQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLFL---------------PETPNSPQLV 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 203 NRFFVSRLAITTlSVSVILTFVnasPVlLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTL-------MLV 275
Cdd:cd17361 203 IAILIPFFQQLT-GINVIMFYA---PV-LFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLlleggvqMLA 277
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 549580603 276 SQglfLTAGVTLSLAHTNTVTLFG------LTLICAgFSVGFG 312
Cdd:cd17361 278 SQ---VAIGILLAVKFGDGGELPKayaiavVVLICL-YVAAFA 316
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
26-374 |
7.27e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGS-LFLSGRFLQGVG 104
Cdd:cd17353 26 NPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFLGYGVLGGIG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 105 AGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILR----- 179
Cdd:cd17353 106 AGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDppkgw 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 180 ---ETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSrgdyAITMALTAGVSMVV 256
Cdd:cd17353 186 vppGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLD----AGIAALAVSILSIF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 257 SFSTPFALGLF-----KPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVGFGVAMSQALGP-------FSL 324
Cdd:cd17353 262 NGGGRPFWGWLsdkigRKNTLSIA--FLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTAdffgtknAGT 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 549580603 325 RAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLI 374
Cdd:cd17353 340 NYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
48-177 |
7.46e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.41 E-value: 7.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 48 LAGMATAmLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAK 127
Cdd:cd17358 52 LGALIGA-LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 549580603 128 vLSLLNGITCIVPVLapvVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFI 177
Cdd:cd17358 131 -LGSLNQLLVNIGIL---LGYVLGSFLPWRTLALIGAIPPVVFLILLFFI 176
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
26-104 |
9.01e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 41.26 E-value: 9.01e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVG 104
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
138-379 |
1.07e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.05 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 138 IVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLV----NRFFVsRLAIT 213
Cdd:cd17332 151 LVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKallkNRPFL-ILLLA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 214 TLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTN 293
Cdd:cd17332 230 YLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPG 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 294 TVTLFGLTLICAGFSVGFGVAMSQALGPFSL----------RAGVASSTLGIAQVCGSSLWIWLAA-ILGISAMNMLIGI 362
Cdd:cd17332 310 NLVLILVLAVLAGIGYGGANLLPWAMLADVIdygelktgkrREGIFYSVMTFFRKLGLALAGALVGlILSLAGYVANAAA 389
|
250
....*....|....*..
gi 549580603 363 LIGCSIVSILLIFSVAP 379
Cdd:cd17332 390 QSASALNGIRLLIAVLP 406
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
9-318 |
1.32e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRA 88
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 89 SEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIV----PVLAPVVGHLIMLRFPWQSLFYTMS 164
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGfalgPLLLALVGTAGALPFLIAAVLLLLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 165 AmgIIVGLLSLFILRETRPARLAPRDLSRSSPAAeslvnrffvsrLAITTLSVSVILTFVNASPVLLMEvMGFSRGDYAI 244
Cdd:cd17477 162 L--VPLLLTRRAAPEIEEAESISLRRLLRIAPLA-----------LLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAAL 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549580603 245 TMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLTLICAGFSVG-FGVAMSQA 318
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALA 302
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
45-183 |
1.39e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.64 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 45 SVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHR 124
Cdd:cd17315 41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549580603 125 RAKVLSLLNGITCIVPVLAPVVGHLIMLRFP--WQSLFYTMSAMGIIVGLLsLFILRETRP 183
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLL-MFFLPESRA 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-179 |
2.35e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 9 FVLVLLYPAGIDMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSR 87
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 88 ASEGS--LFLSGRFLQGVGAGGCYVVAFAILRDTLDEH-------RRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQS 158
Cdd:COG2211 314 LGPGNlwLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
170 180 190
....*....|....*....|....*....|..
gi 549580603 159 -----------LFYTMSAMGIIVGLLSLFILR 179
Cdd:COG2211 394 gaaqspsaltgIRLLFFLLPAVLLLLAALLLL 425
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
26-169 |
2.59e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 39.52 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGA 105
Cdd:PRK10213 43 LTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLAL 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 549580603 106 GGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGII 169
Cdd:PRK10213 123 GGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVL 186
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
42-219 |
3.28e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.52 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 42 IAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVgAGGCYVVAFAILRDTLD 121
Cdd:PRK09874 58 LVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 122 EHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPArLAPRDLSRSSPAAESL 201
Cdd:PRK09874 137 RNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQP-VSKKEMLHMREVVTSL 215
|
170
....*....|....*...
gi 549580603 202 VNRFFVSRLAITTLSVSV 219
Cdd:PRK09874 216 KNPKLVLSLFVTTLIIQV 233
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
27-188 |
5.13e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.76 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 27 PRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAG 106
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 107 GCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLLSLFILRETRPARL 186
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA 179
|
..
gi 549580603 187 AP 188
Cdd:cd17475 180 AT 181
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-173 |
6.34e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549580603 30 AADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGALVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCY 109
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 549580603 110 VVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVVGHLIMLRFPWQSLFYTMSAMGIIVGLL 173
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| |
