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Conserved domains on  [gi|549582276|gb|ERN86984|]
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transcriptional regulator [Salmonella enterica subsp. enterica serovar Kentucky str. 20793]

Protein Classification

two-component system response regulator CreB( domain architecture ID 11485191)

two-component system response regulator CreB is involved in catabolic regulation; consists of a receiver domain and a helix-turn-helix DNA-binding domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-228 4.37e-155

DNA-binding response regulator CreB; Provisional


:

Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 429.00  E-value: 4.37e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILF 80
Cdd:PRK11083   1 MQQPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEF 160
Cdd:PRK11083  81 LTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFAAPSPVIRIGHFELDEPAARISYFGTPLTLTRYEF 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276 161 LLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRS 228
Cdd:PRK11083 161 LLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRP 228
 
Name Accession Description Interval E-value
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-228 4.37e-155

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 429.00  E-value: 4.37e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILF 80
Cdd:PRK11083   1 MQQPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEF 160
Cdd:PRK11083  81 LTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFAAPSPVIRIGHFELDEPAARISYFGTPLTLTRYEF 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276 161 LLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRS 228
Cdd:PRK11083 161 LLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRP 228
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 3-208 2.64e-69

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 210.97  E-value: 2.64e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   3 QPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLT 82
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  83 ARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKfaapsPVVRTGHFeLNEPAAQIAWFGTPLSLTRYEFLL 162
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA-----EVLRVGDL-LDLAAREVTRDGEPVELTPKEFRL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 549582276 163 LKTLLLSPERVYSRQQLMDIVWSDAqETFDRTVDTHIKTLRAKLRA 208
Cdd:COG0745  155 LELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLED 199
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 3-226 9.51e-58

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 182.53  E-value: 9.51e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276    3 QPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLL--EHHPALPILF 80
Cdd:TIGR02154   2 TRRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRrrPETRAIPIIM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKfAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEF 160
Cdd:TIGR02154  82 LTARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRP-QLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276  161 LLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRaklRAINPD--LSPINTHRGMGYSL 226
Cdd:TIGR02154 161 RLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLR---KALNPFglEDPVQTVRGAGYRF 225
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
9-224 2.47e-50

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 163.12  E-value: 2.47e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHhPALPILFLTARSDEV 88
Cdd:NF040689   4 VDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAE-SGVPIIMLTAKSDTV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  89 DRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKkfAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLKTLLL 168
Cdd:NF040689  83 DVVRGLEAGADDYVVKPFKPKELVARIRARLRRSE--DEESEVLRIGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVALAR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276 169 SPERVYSRQQLMDIVW--SDAQETfdRTVDTHIKTLRAKLRaINPDlSP--INTHRGMGY 224
Cdd:NF040689 161 KPGQVFSREELLEQVWgyRHAADT--RLVNVHVQRLRAKIE-RDPE-NPeiVVTVRGVGY 216
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-105 1.53e-48

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 154.49  E-value: 1.53e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd17574    2 VVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDEE 81

                         90
                 ....*....|....*...
gi 549582276  88 VDRLLGLEIGADDYVAKP 105
Cdd:cd17574   82 EDKVLGLELGADDYITKP 99
resp_reg_YycF NF040534
response regulator YycF;
5-227 4.75e-43

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 144.86  E-value: 4.75e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPaLPILFLTAR 84
Cdd:NF040534   2 KILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYD-MPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAA-----PSPVVRTGHFELNEPAAQIAWFGTPLSLTRYE 159
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTeeeeeENNEIVIGSLTIHPDAYTVKKRGETIELTHRE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549582276 160 FLLLKTLLLSPERVYSRQQLMDIVWSdaqetFD-----RTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLR 227
Cdd:NF040534 161 FELLHYLAKHIGQVMTREHLLQTVWG-----YDyfgdvRTVDVTVRRLREKIEDNPSHPEWIVTRRGVGYYLR 228
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-116 2.70e-33

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 116.10  E-value: 2.70e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276    6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 549582276   86 DEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 150-226 7.69e-18

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 74.90  E-value: 7.69e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276   150 GTPLSLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAiNPDLSPINTHRGMGYSL 226
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLED-DGDPRLIETVRGVGYRL 76
 
Name Accession Description Interval E-value
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-228 4.37e-155

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 429.00  E-value: 4.37e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILF 80
Cdd:PRK11083   1 MQQPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEF 160
Cdd:PRK11083  81 LTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFAAPSPVIRIGHFELDEPAARISYFGTPLTLTRYEF 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276 161 LLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRS 228
Cdd:PRK11083 161 LLLKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRP 228
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 3-208 2.64e-69

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 210.97  E-value: 2.64e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   3 QPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLT 82
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  83 ARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKfaapsPVVRTGHFeLNEPAAQIAWFGTPLSLTRYEFLL 162
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAA-----EVLRVGDL-LDLAAREVTRDGEPVELTPKEFRL 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 549582276 163 LKTLLLSPERVYSRQQLMDIVWSDAqETFDRTVDTHIKTLRAKLRA 208
Cdd:COG0745  155 LELLMRNPGRVVSREQLLEEVWGYD-YGDDRTVDVHISRLRKKLED 199
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 2-224 5.29e-61

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 191.05  E-value: 5.29e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   2 QQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLlEHHPALPILFL 81
Cdd:PRK10710   9 NTPRILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREI-RRFSDIPIVMV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  82 TARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFL 161
Cdd:PRK10710  88 TAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPQRELQQQDAESPLIIDESRFQASWRGKMLDLTPAEFR 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549582276 162 LLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGY 224
Cdd:PRK10710 168 LLKTLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGY 230
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 3-226 9.51e-58

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 182.53  E-value: 9.51e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276    3 QPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLL--EHHPALPILF 80
Cdd:TIGR02154   2 TRRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRrrPETRAIPIIM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKfAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEF 160
Cdd:TIGR02154  82 LTARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRP-QLSDEVIEVGDLSLDPVAHRVFRGGQPLSLGPTEF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276  161 LLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRaklRAINPD--LSPINTHRGMGYSL 226
Cdd:TIGR02154 161 RLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLR---KALNPFglEDPVQTVRGAGYRF 225
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
9-224 2.47e-50

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 163.12  E-value: 2.47e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHhPALPILFLTARSDEV 88
Cdd:NF040689   4 VDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAE-SGVPIIMLTAKSDTV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  89 DRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKkfAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLKTLLL 168
Cdd:NF040689  83 DVVRGLEAGADDYVVKPFKPKELVARIRARLRRSE--DEESEVLRIGDLTIDVAGHEVTRGGEEIPLTPLEFDLLVALAR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276 169 SPERVYSRQQLMDIVW--SDAQETfdRTVDTHIKTLRAKLRaINPDlSP--INTHRGMGY 224
Cdd:NF040689 161 KPGQVFSREELLEQVWgyRHAADT--RLVNVHVQRLRAKIE-RDPE-NPeiVVTVRGVGY 216
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-105 1.53e-48

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 154.49  E-value: 1.53e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd17574    2 VVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDEE 81

                         90
                 ....*....|....*...
gi 549582276  88 VDRLLGLEIGADDYVAKP 105
Cdd:cd17574   82 EDKVLGLELGADDYITKP 99
orf27 CHL00148
Ycf27; Reviewed
 2-229 1.23e-46

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 154.49  E-value: 1.23e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   2 QQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCrQLLEHHPALPILFL 81
Cdd:CHL00148   5 SKEKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVC-QEIRKESDVPIIML 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  82 TARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSP-----VVRTGHFELNEPAAQIAWFGTPLSLT 156
Cdd:CHL00148  84 TALGDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSSKipnssIIRIGFLKIDLNKKQVYKNNERIRLT 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276 157 RYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETF--DRTVDTHIKTLRAKLR--AINPDLspINTHRGMGYSLRSV 229
Cdd:CHL00148 164 GMEFSLLELLISKSGEIFSRATILKEVWGYTPERHidTRVVDVHISRLRAKLEddPSNPDL--ILTARGTGYLFQSI 238
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 9-120 1.69e-45

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 147.42  E-value: 1.69e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILFLTARSD 86
Cdd:cd19937    3 VDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILrsDPKTSSIPIIMLTAKGE 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  87 EVDRLLGLEIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:cd19937   83 EFDKVLGLELGADDYITKPFSPRELLARVKAVLR 116
resp_reg_YycF NF040534
response regulator YycF;
5-227 4.75e-43

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 144.86  E-value: 4.75e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPaLPILFLTAR 84
Cdd:NF040534   2 KILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYD-MPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAA-----PSPVVRTGHFELNEPAAQIAWFGTPLSLTRYE 159
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTeeeeeENNEIVIGSLTIHPDAYTVKKRGETIELTHRE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549582276 160 FLLLKTLLLSPERVYSRQQLMDIVWSdaqetFD-----RTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLR 227
Cdd:NF040534 161 FELLHYLAKHIGQVMTREHLLQTVWG-----YDyfgdvRTVDVTVRRLREKIEDNPSHPEWIVTRRGVGYYLR 228
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 6-121 1.04e-40

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 135.17  E-value: 1.04e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAKD 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17615   82 SVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 6-121 1.11e-40

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 135.19  E-value: 1.11e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILFLTARS 85
Cdd:cd19939    2 ILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHS-HVPILMLTART 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd19939   81 EEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 6-121 2.16e-39

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 131.66  E-value: 2.16e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPaLPILFLTARS 85
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQ-VPVLMLTARG 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17623   80 DDIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 8-120 3.89e-39

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 131.07  E-value: 3.89e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd17624    3 LVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARDGV 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:cd17624   83 DDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 6-226 9.51e-38

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 131.07  E-value: 9.51e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276    6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRSGKQTPVLFLTARD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKkfAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLKT 165
Cdd:TIGR01387  81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRSH--SLNSTVLEIADLRMDSVRHRVSRGNIRITLTRKEFQLLWL 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549582276  166 LLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKlraINPDLSP--INTHRGMGYSL 226
Cdd:TIGR01387 159 LMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRAK---VDDPFEEklIHTIRGMGYVL 218
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 8-121 1.68e-37

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 127.15  E-value: 1.68e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILFLTARSDE 87
Cdd:cd17614    3 VVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLTAKDSE 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17614   82 VDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
ompR PRK09468
osmolarity response regulator; Provisional
 2-224 2.13e-37

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 130.48  E-value: 2.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   2 QQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGlPALEKARQQRP-DAVILDVGLPDISGFELCRQLLEHHPALPILF 80
Cdd:PRK09468   4 ENYKILVVDDDMRLRALLERYLTEQGFQVRSAANA-EQMDRLLTRESfHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFA--APSP---VVRTGHFELNEPAAQIAWFGTPLSL 155
Cdd:PRK09468  83 LTAKGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAPELpgAPSQeeeVIAFGKFKLNLGTRELFRGDEPMPL 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549582276 156 TRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRaklRAINPDLSP---INTHRGMGY 224
Cdd:PRK09468 163 TTGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLR---RLIEEDPAHpryIQTVWGLGY 231
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
5-229 2.65e-37

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 130.31  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKArQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILFLTAR 84
Cdd:PRK10955   3 KILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLL-DDSIDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRV------KKFAAPSPVVRTGHFELNePAAQIAWF-GTPLSLTR 157
Cdd:PRK10955  81 GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRShwseqqQNNDNGSPTLEVDALSLN-PGRQEASFdGQTLELTG 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549582276 158 YEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSLRSV 229
Cdd:PRK10955 160 TEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSA 231
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 5-119 2.70e-37

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 126.34  E-value: 2.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLlEHHPALPILFLTAR 84
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREI-RRFSDVPIIMVTAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd19938   80 VEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
5-228 5.56e-37

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 129.45  E-value: 5.56e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPA--LPILFLT 82
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdIPVVMLT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  83 ARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAApSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLL 162
Cdd:PRK10161  84 ARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAV-EEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 549582276 163 LKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDlSPINTHRGMGYSLRS 228
Cdd:PRK10161 163 LHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHD-RMVQTVRGTGYRFST 227
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 8-121 2.57e-36

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 123.87  E-value: 2.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd17625    2 VVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDAV 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17625   82 EDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 8-120 4.44e-35

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 122.71  E-value: 4.44e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILFLTARS 85
Cdd:COG3706    6 VVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLraDPRTADIPIIFLTALD 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:COG3706   86 DEEDRARALEAGADDYLTKPFDPEELLARVDLVAR 120
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 2-123 3.02e-34

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 122.20  E-value: 3.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   2 QQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPIL 79
Cdd:COG3437    5 QAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLraDPSTRDIPVI 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 549582276  80 FLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVK 123
Cdd:COG3437   85 FLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRR 128
PRK10766 PRK10766
two-component system response regulator TorR;
6-213 9.01e-34

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 120.53  E-value: 9.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHhPALPILFLTARS 85
Cdd:PRK10766   5 ILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSR-STVGIILVTGRT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRV-------KKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRY 158
Cdd:PRK10766  84 DSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRIslarqaqPHAQEEDNCYRFAGYCLNVSRRTLERNGEPIKLTKA 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 549582276 159 EFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLraiNPDL 213
Cdd:PRK10766 164 EYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKL---NPDL 215
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 6-121 1.90e-33

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 116.71  E-value: 1.90e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17627   81 SVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-124 2.36e-33

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 116.87  E-value: 2.36e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPI 78
Cdd:COG0784    3 LGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIraLPRLPDIPI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 549582276  79 LFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKK 124
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-116 2.70e-33

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 116.10  E-value: 2.70e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276    6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 549582276   86 DEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK11173 PRK11173
two-component response regulator; Provisional
 1-224 2.95e-33

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 119.73  E-value: 2.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILF 80
Cdd:PRK11173   1 MQTPHILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQA-NVALMF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPS-PVVRTGHFELN------EPAAQIAWFGTPL 153
Cdd:PRK11173  80 LTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSeERRSVESYKFNgweldiNSRSLISPDGEQY 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549582276 154 SLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGY 224
Cdd:PRK11173 160 KLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGY 230
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 8-121 3.24e-33

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 115.84  E-value: 3.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd19934    3 LVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARDSW 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd19934   83 QDKVEGLDAGADDYLTKPFHIEELLARLRALIRR 116
PRK15479 PRK15479
transcriptional regulator TctD;
8-226 1.22e-32

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 117.90  E-value: 1.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:PRK15479   5 LAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTARSAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKkfAAPSPVVRTGHFELNEPAAQIAWfGTPLSLTRYEFLLLKTLL 167
Cdd:PRK15479  85 ADRVKGLNVGADDYLPKPFELEELDARLRALLRRSA--GQVQEVQQLGELIFHDEGYFLLQ-GQPLALTPREQALLTVLM 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 549582276 168 LSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINpdlSPINTHRGMGYSL 226
Cdd:PRK15479 162 YRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSD---VRITTLRGLGYVL 217
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 8-105 2.73e-32

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 112.92  E-value: 2.73e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd19935    3 VVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARDSV 82

                         90
                 ....*....|....*...
gi 549582276  88 VDRLLGLEIGADDYVAKP 105
Cdd:cd19935   83 EDRVKGLDLGADDYLVKP 100
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 3-224 6.87e-32

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 116.06  E-value: 6.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   3 QPQVWLVEDEQGIADTLIYTLQLEG---FTVELFARGLpaLEkARQQRPDAVILDVGLPDISGFELCRQLlEHHPALPIL 79
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTALEGDGmrvFEAETLQRGL--LE-AATRKPDLIILDLGLPDGDGIEFIRDL-RQWSAIPVI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  80 FLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYE 159
Cdd:PRK10529  77 VLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATPAPDPLVKFSDVTVDLAARVIHRGEEEVHLTPIE 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549582276 160 FLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGY 224
Cdd:PRK10529 157 FRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGY 221
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-105 5.15e-31

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 109.62  E-value: 5.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKADE 81

                         90
                 ....*....|....*...
gi 549582276  88 VDRLLGLEIGADDYVAKP 105
Cdd:cd00156   82 EDAVRALELGADDYLVKP 99
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 5-226 7.62e-31

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 113.48  E-value: 7.62e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPvVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLK 164
Cdd:PRK09836  82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQ-FQVADLMVDLVSRKVTRSGTRITLTSKEFTLLE 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 549582276 165 TLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKlraINPDLSP--INTHRGMGYSL 226
Cdd:PRK09836 161 FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGK---IDNDFEPklIQTVRGVGYML 221
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 2-121 1.04e-30

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 116.99  E-value: 1.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   2 QQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFL 81
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 549582276  82 TARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALER 120
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 5-119 1.85e-30

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 109.10  E-value: 1.85e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHhPALPILFLTAR 84
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAE-SGVPIVMLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17626   81 SDTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 4-119 2.79e-30

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 108.49  E-value: 2.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLL--EHHPALPILFL 81
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKrdEMTRDIPIIML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 549582276  82 TARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
PRK10336 PRK10336
two-component system response regulator QseB;
5-226 9.46e-30

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 110.37  E-value: 9.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAapSPVVRTGHFELNePAAQIAWF-GTPLSLTRYEFLLL 163
Cdd:PRK10336  82 DALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQA--SNELRHGNVMLD-PGKRIATLaGEPLTLKPKEFALL 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549582276 164 KTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAinpdlSPINTHRGMGYSL 226
Cdd:PRK10336 159 ELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGS-----DFIRTVHGIGYTL 216
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 6-120 2.60e-29

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 105.92  E-value: 2.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILFLTARS 85
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKY-QGPILLLTALD 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:cd17622   82 SDIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
PRK10643 PRK10643
two-component system response regulator PmrA;
8-226 8.90e-28

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 105.12  E-value: 8.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:PRK10643   5 IVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTARDTL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRvkKFAAPSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLKTLL 167
Cdd:PRK10643  85 EDRVAGLDVGADDYLVKPFALEELHARIRALIRR--HQGQGENELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSRLM 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 549582276 168 LSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAinpdlSPINTHRGMGYSL 226
Cdd:PRK10643 163 LKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGK-----DRIRTVRGFGYML 216
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 4-116 3.39e-27

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 100.54  E-value: 3.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHhPALPILFLTA 83
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ-SEVGIILVTG 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 549582276  84 RSDEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:cd17619   80 RDDEVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 8-105 5.11e-27

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 99.44  E-value: 5.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILFLTARSDE 87
Cdd:cd19936    3 LVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKS-TLPVIFLTSKDDE 81

                         90
                 ....*....|....*...
gi 549582276  88 VDRLLGLEIGADDYVAKP 105
Cdd:cd19936   82 IDEVFGLRMGADDYITKP 99
PRK10816 PRK10816
two-component system response regulator PhoP;
5-224 6.48e-27

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 102.89  E-value: 6.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:PRK10816   2 RVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAapSPVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLK 164
Cdd:PRK10816  82 ESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLA--SQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIME 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276 165 TLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDlSPINTHRGMGY 224
Cdd:PRK10816 160 TLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQ-EVITTVRGQGY 218
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 6-105 1.33e-26

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 98.42  E-value: 1.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQlLEHHPALPILFLTARS 85
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQ-LRARSNVPVIMVTAKD 79

                         90       100
                 ....*....|....*....|
gi 549582276  86 DEVDRLLGLEIGADDYVAKP 105
Cdd:cd17621   80 SEIDKVVGLELGADDYVTKP 99
PRK11517 PRK11517
DNA-binding response regulator HprR;
5-229 6.53e-26

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 100.36  E-value: 6.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHpALPILFLTAR 84
Cdd:PRK11517   2 KILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAK-QTPVICLTAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAApspVVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLK 164
Cdd:PRK11517  81 DSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNS---TLEISGLRMDSVSQSVSRDNISITLTRKEFQLLW 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 549582276 165 TLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRaiNP-DLSPINTHRGMGYSLRSV 229
Cdd:PRK11517 158 LLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVD--DPfPEKLIATIRGMGYSFVAV 221
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 8-106 1.85e-25

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 95.64  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLE--HHPALPILFLTARS 85
Cdd:cd17538    4 VVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEdpETRHIPVIMITALD 83

                         90       100
                 ....*....|....*....|.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPF 106
Cdd:cd17538   84 DREDRIRGLEAGADDFLSKPI 104
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 6-105 2.41e-24

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 92.61  E-value: 2.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEhHPALPILFLTARS 85
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLRE-WSAVPVIVLSARD 79

                         90       100
                 ....*....|....*....|
gi 549582276  86 DEVDRLLGLEIGADDYVAKP 105
Cdd:cd17620   80 EESDKIAALDAGADDYLTKP 99
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-127 8.87e-24

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 92.34  E-value: 8.87e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTL-QLEGFTVELFARGLP-ALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPI 78
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLeRLPGFEVVGVASSGEeALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 549582276  79 LFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAA 127
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRE 129
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 19-106 1.44e-23

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 90.65  E-value: 1.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  19 LIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQlLEHHPA---LPILFLTARSDEVDRLLGLE 95
Cdd:cd19920   14 LSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRR-LKADPAtrhIPVIFLTALTDTEDKVKGFE 92

                         90
                 ....*....|.
gi 549582276  96 IGADDYVAKPF 106
Cdd:cd19920   93 LGAVDYITKPF 103
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 6-119 2.66e-23

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 90.42  E-value: 2.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPaLPILFLTARS 85
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISN-VPIIFISSRD 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd18159   80 DNMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 4-116 6.89e-23

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 89.25  E-value: 6.89e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTA 83
Cdd:cd19919    1 KTVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTA 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 549582276  84 RSDEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:cd19919   81 HSDLDSAVSAYQGGAFEYLPKPFDIDEAVALVE 113
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 8-119 1.63e-22

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 88.54  E-value: 1.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHH--PALPILFLTARS 85
Cdd:cd17598    3 IVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPdlKDIPVILLTTLS 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17598   83 DPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 8-105 1.74e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 87.91  E-value: 1.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQ-LEGFTVELFAR-GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:COG4753    4 IVDDEPLIREGLKRILEwEAGFEVVGEAEnGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILSGYS 83

                         90       100
                 ....*....|....*....|
gi 549582276  86 DEVDRLLGLEIGADDYVAKP 105
Cdd:COG4753   84 DFEYAQEAIKLGADDYLLKP 103
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 6-110 5.26e-22

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 86.74  E-value: 5.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHP--ALPILFLTA 83
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWlaNTPAIALTG 80

                         90       100
                 ....*....|....*....|....*..
gi 549582276  84 RSDEVDRLLGLEIGADDYVAKPFSPRE 110
Cdd:cd17580   81 YGQPEDRERALEAGFDAHLVKPVDPDE 107
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 49-224 3.11e-21

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 88.33  E-value: 3.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  49 DAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLrRVKKFAAP 128
Cdd:PRK13856  47 DVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGDRLEEADKVVALELGATDFIAKPFGTREFLARIRVAL-RVRPNVVR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276 129 SPVVRTGHFE---LNEPAAQ-IAWFGTPLSLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRA 204
Cdd:PRK13856 126 TKDRRSFCFAdwtLNLRQRRlISEAGGEVKLTAGEFNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRR 205

                        170       180
                 ....*....|....*....|..
gi 549582276 205 KLRA--INPDLspINTHRGMGY 224
Cdd:PRK13856 206 KLEQdpANPQL--IKTARGAGY 225
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 24-118 5.14e-21

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 84.42  E-value: 5.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  24 QLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILFLTARSDEVDRLLGLEIGADDY 101
Cdd:cd17551   22 SAGYLEVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLraLPGLEDVPIVMITADTDREVRLRALEAGATDF 101

                         90
                 ....*....|....*..
gi 549582276 102 VAKPFSPREVSARVRTL 118
Cdd:cd17551  102 LTKPFDPVELLARVRNL 118
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 137-226 1.32e-20

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 82.53  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276 137 FELNEPAAQIAWFGTPLSLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAiNPDLSPI 216
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLED-DPEPRLI 79

                         90
                 ....*....|
gi 549582276 217 NTHRGMGYSL 226
Cdd:cd00383   80 KTVRGVGYRL 89
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 6-119 2.00e-20

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 82.84  E-value: 2.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 6-121 3.17e-20

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 84.38  E-value: 3.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHG 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 549582276  86 DE---VDRLLGleiGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:COG4566   82 DVpmaVRAMKA---GAVDFLEKPFDDQALLDAVRRALAR 117
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 8-120 4.76e-20

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 81.79  E-value: 4.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLE-GFTV--ElFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:cd17535    3 IVDDHPLVREGLRRLLESEpDIEVvgE-AADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 5-119 4.83e-20

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 82.21  E-value: 4.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLE-GFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEhHPA---LPILF 80
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLaGWEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQA-NPEtqsIPVIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17552   82 LTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
150-226 9.67e-20

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 79.86  E-value: 9.67e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276  150 GTPLSLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAINPDLSPINTHRGMGYSL 226
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 8-111 1.82e-19

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 80.21  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELC---RQLLEHHPALPILFLTAR 84
Cdd:cd17546    3 VVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATrriRELEGGGRRTPIIALTAN 82

                         90       100
                 ....*....|....*....|....*..
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREV 111
Cdd:cd17546   83 ALEEDREKCLEAGMDDYLSKPVKLDQL 109
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-127 2.15e-19

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 82.31  E-value: 2.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFAR-GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPAlPIL 79
Cdd:COG3707    1 MRGLRVLVVDDEPLRRADLREGLREAGYEVVAEAAdGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPA-PVI 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 549582276  80 FLTARSDE--VDRLlgLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAA 127
Cdd:COG3707   80 LLTAYSDPelIERA--LEAGVSAYLVKPLDPEDLLPALELALARFRELRA 127
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 8-113 4.44e-19

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 79.37  E-value: 4.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTV-ELFARGLPALEKARQQRPDAVILDVGLP-DISGFELCRQLLEHHPaLPILFLTARS 85
Cdd:cd17534    5 IVEDEAIIALDLKEILESLGYEVvGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFD-IPVIFLTAYS 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 549582276  86 DE--VDRllGLEIGADDYVAKPFSPREVSA 113
Cdd:cd17534   84 DEetLER--AKETNPYGYLVKPFNERELKA 111
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 6-116 2.36e-18

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 77.49  E-value: 2.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLlEHHPALPILFLTA-R 84
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTI-RARSDVPIIIISGdR 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:cd17594   81 RDEIDRVVGLELGADDYLAKPFGLRELLARVR 112
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 6-108 3.41e-18

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 77.53  E-value: 3.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHG 80

                         90       100
                 ....*....|....*....|....*.
gi 549582276  86 D---EVDrllGLEIGADDYVAKPFSP 108
Cdd:cd17549   81 DvpmAVE---AMRAGAYDFLEKPFDP 103
pleD PRK09581
response regulator PleD; Reviewed
 23-120 3.90e-18

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 82.26  E-value: 3.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  23 LQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL----LEHHpaLPILFLTARSDEVDRLLGLEIGA 98
Cdd:PRK09581  22 LLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLksdpATTH--IPVVMVTALDDPEDRVRGLEAGA 99

                         90       100
                 ....*....|....*....|..
gi 549582276  99 DDYVAKPFSPREVSARVRTLLR 120
Cdd:PRK09581 100 DDFLTKPINDVALFARVKSLTR 121
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 150-226 7.69e-18

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 74.90  E-value: 7.69e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276   150 GTPLSLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLRAiNPDLSPINTHRGMGYSL 226
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLED-DGDPRLIETVRGVGYRL 76
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 8-130 8.73e-18

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 79.09  E-value: 8.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTL-QLEGFT-VELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:COG3279    6 IVDDEPLARERLERLLeKYPDLEvVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTTAYD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 549582276  86 DEVdrLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSP 130
Cdd:COG3279   86 EYA--LEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEA 128
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 8-124 2.78e-17

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 74.68  E-value: 2.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLE--GFTVELFAR-GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:cd17536    3 IVDDEPLIREGLKKLIDWEelGFEVVGEAEnGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILSGY 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 549582276  85 SD-----EvdrllGLEIGADDYVAKPFSPREvsarVRTLLRRVKK 124
Cdd:cd17536   83 DDfeyaqK-----AIRLGVVDYLLKPVDEEE----LEEALEKAKE 118
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 8-116 3.74e-17

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 76.11  E-value: 3.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:COG4567    9 LVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGYASI 88

                         90       100
                 ....*....|....*....|....*....
gi 549582276  88 VDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:COG4567   89 ATAVEAIKLGADDYLAKPADADDLLAALE 117
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 8-105 7.20e-17

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 73.18  E-value: 7.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQlLEHHPAL---PILFLTAR 84
Cdd:cd19927    3 LVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGK-LRKNADFdtiPVIFLTAK 81

                         90       100
                 ....*....|....*....|.
gi 549582276  85 SDEVDRLLGLEIGADDYVAKP 105
Cdd:cd19927   82 GMTSDRIKGYNAGCDGYLSKP 102
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 9-118 8.92e-17

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 73.41  E-value: 8.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEV 88
Cdd:cd17554    6 VDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAYSEYK 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 549582276  89 DRLLGLeiGADDYVAKPFSPREVSARVRTL 118
Cdd:cd17554   86 SDFSSW--AADAYVVKSSDLTELKETIKRL 113
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
6-141 1.07e-15

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 75.27  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREvsarVRTLLRRVKKFAAPSPVVRTGHFELNE 141
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIKPFDLDE----LNLIVQRALQLQSMKKEIRHLHQALST 138
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 8-111 1.16e-15

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 70.16  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLT----- 82
Cdd:cd17563    5 LVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTgyasi 84

                         90       100
                 ....*....|....*....|....*....
gi 549582276  83 ARSDEVDRLlgleiGADDYVAKPFSPREV 111
Cdd:cd17563   85 ATAVEAIKL-----GADDYLAKPADADEI 108
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 6-116 1.44e-15

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 70.32  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHG 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:cd17537   83 DVPMAVEAMKAGAVDFLEKPFRDQVLLDAIE 113
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 9-116 1.79e-15

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 69.88  E-value: 1.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRqLLEHHPAL---PILFLTARS 85
Cdd:cd17548    5 VEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATR-LLKEDPATrdiPVIALTAYA 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:cd17548   84 MKGDREKILEAGCDGYISKPIDTREFLETVA 114
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 9-224 2.58e-15

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 72.36  E-value: 2.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPAlPILFLTARSDEV 88
Cdd:PRK10701   7 VEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQG-PIVLLTSLDSDM 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  89 DRLLGLEIGADDYVAKPFSPREVSARVRTLLRR-----VKKFAAPSPV-----VRTGHFELNEPAAQIAWFGTPLSLTRY 158
Cdd:PRK10701  86 NHILALEMGACDYILKTTPPAVLLARLRLHLRQneqatQTKGLQETSLtpykaLHFGTLTIDPVNRQVTLAGEEISLSTA 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276 159 EFLLLKTLLLSPERVYSRQQLMDIVWSDAQETFDRTVDTHIKTLRAKLR--AINPdlSPINTHRGMGY 224
Cdd:PRK10701 166 DFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLdnAAEP--YRIKTVRNKGY 231
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 6-107 2.92e-15

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 69.45  E-value: 2.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFL---- 81
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIsghg 80

                         90       100
                 ....*....|....*....|....*....
gi 549582276  82 ---TARSdevdrllGLEIGADDYVAKPFS 107
Cdd:cd17550   81 tieTAVK-------ATKLGAYDFIEKPLS 102
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 9-119 5.67e-15

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 68.48  E-value: 5.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEhHPA---LPILFLTARS 85
Cdd:cd17562    6 VDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRK-LPAykfTPILMLTTES 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17562   85 SDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 1-115 7.80e-15

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 72.60  E-value: 7.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILF 80
Cdd:PRK10923   1 MQRGIVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVII 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:PRK10923  81 MTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALV 115
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 6-121 8.10e-15

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 68.49  E-value: 8.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEgFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILfLTA 83
Cdd:cd17539    1 VLLVDDRPSSAERIAAMLSSE-HEVVVEADPDEALFRAAEGPFDLVIVSLALEDFDGLRLCSQLrsLERTRQLPIL-AVA 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 549582276  84 RSDEVDRLL-GLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17539   79 DPGDRGRLIrALEIGVNDYLVRPIDPNELLARVRTQIRR 117
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 9-105 2.90e-14

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 66.24  E-value: 2.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILFLTARSD 86
Cdd:cd17602    4 VDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLrkSSALKDTPIIMLTGKDG 83

                         90
                 ....*....|....*....
gi 549582276  87 EVDRLLGLEIGADDYVAKP 105
Cdd:cd17602   84 LVDRIRAKMAGASGYLTKP 102
PRK15369 PRK15369
two component system response regulator;
6-111 2.13e-13

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 66.64  E-value: 2.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTL------QLEGFTVElfarGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPIL 79
Cdd:PRK15369   6 ILLVDDHELIINGIKNMLapypryKIVGQVDN----GLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNIL 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 549582276  80 FLTARSDEVDRLLGLEIGADDYVAKPfSPREV 111
Cdd:PRK15369  82 VLTARQEEHMASRTLAAGALGYVLKK-SPQQI 112
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 5-121 3.05e-13

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 63.97  E-value: 3.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFAR-GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPAlPILFLTA 83
Cdd:cd19932    2 RVLIAEDEALIRMDLREMLEEAGYEVVGEASdGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIA-PIVLLTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 549582276  84 RSDE--VDRllGLEIGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd19932   81 YSQQdlVER--AKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 4-119 3.24e-13

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 63.84  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQLEGFTVELFA-RGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLT 82
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVGEAaNGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 549582276  83 ARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17542   81 AMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 6-121 5.52e-13

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 63.37  E-value: 5.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 549582276  86 dEVD------RLlgleiGADDYVAKPFSPREVSARVRTLLRR 121
Cdd:cd17572   81 -SVDiaveamRL-----GAYDFLEKPFDADRLRVTVRNALKH 116
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 9-105 7.49e-13

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 62.99  E-value: 7.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   9 VEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEV 88
Cdd:cd17555    6 IDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGAGVMS 85

                         90
                 ....*....|....*..
gi 549582276  89 DRLLGLEIGADDYVAKP 105
Cdd:cd17555   86 DAVEALRLGAWDYLTKP 102
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 8-124 7.71e-13

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 62.94  E-value: 7.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEG--FTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLE-HHPALpILFLTA- 83
Cdd:cd17532    3 IVDDEPLAREELRYLLEEHPdiEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKlAKPPL-IVFVTAy 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 549582276  84 RSDEVDrllGLEIGADDYVAKPFSprevSARVRTLLRRVKK 124
Cdd:cd17532   82 DEYAVE---AFELNAVDYLLKPFS----EERLAEALAKLRK 115
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 39-123 2.56e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 61.64  E-value: 2.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  39 ALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPaLPILFLTARSDE-VDR-LLGLEIGADDYVAKPFSPREVSARV- 115
Cdd:cd17541   38 ALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVMVSSLTEEgAEItLEALELGAVDFIAKPSGGISLDLEEi 116


                 ....*....
gi 549582276 116 -RTLLRRVK 123
Cdd:cd17541  117 aEELIEKIK 125
fixJ PRK09390
response regulator FixJ; Provisional
 1-131 3.26e-12

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 63.10  E-value: 3.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILF 80
Cdd:PRK09390   1 SDKGVVHVVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 549582276  81 LTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPV 131
Cdd:PRK09390  81 MTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAKSEAV 131
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 6-106 6.81e-12

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 59.82  E-value: 6.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRP-DAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILFISGG 81

                         90       100
                 ....*....|....*....|..
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPF 106
Cdd:cd18160   82 AAAAPELLSDAVGDNATLKKPF 103
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
5-145 1.28e-11

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 63.13  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:PRK10365   7 DILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAY 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549582276  85 SDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPVVRTGHFEL--NEPAAQ 145
Cdd:PRK10365  87 SSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPAVTASQFGMvgKSPAMQ 149
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
36-147 7.60e-11

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 60.55  E-value: 7.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  36 GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPaLPILF---LTARSDEVDrLLGLEIGADDYVAKPFSP---- 108
Cdd:PRK00742  38 GLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRP-TPVVMvssLTERGAEIT-LRALELGAVDFVTKPFLGislg 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 549582276 109 -----REVSARVRTLLRRVKKFAAPSPVVRTGHFELNEPAAQIA 147
Cdd:PRK00742 116 mdeykEELAEKVRAAARARVRALPPRAAAAARAAAAAPAALAAA 159
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 5-119 8.79e-11

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 57.56  E-value: 8.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   5 QVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:cd17553    2 KILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAY 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  85 SdEVDRLL-GLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd17553   82 G-ELDMIQeSKELGALTHFAKPFDIDEIRDAVKKYL 116
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 6-120 1.11e-10

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 56.90  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEG--FTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLT- 82
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDdlEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTt 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 549582276  83 -ARSDEVDRllGLEIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:cd19930   81 fGRPGYFRR--ALAAGVDGYVLKDRPIEELADAIRTVHA 117
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
23-107 1.56e-10

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 60.52  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   23 LQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYV 102
Cdd:PRK09959  978 LNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQANEREKGLSCGMNLCL 1057


                  ....*
gi 549582276  103 AKPFS 107
Cdd:PRK09959 1058 FKPLT 1062
pleD PRK09581
response regulator PleD; Reviewed
 39-121 1.10e-09

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 57.60  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  39 ALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVR 116
Cdd:PRK09581 190 ALFNAAETNYDLVIVSANFENYDPLRLCSQLrsKERTRYVPILLLVDEDDDPRLVKALELGVNDYLMRPIDKNELLARVR 269


                 ....*
gi 549582276 117 TLLRR 121
Cdd:PRK09581 270 TQIRR 274
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 6-106 1.72e-09

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 53.79  E-value: 1.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLI-YTLQLEGFTVELFAR-GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTA 83
Cdd:cd19925    3 VLIVEDDPMVAEIHRaYVEQVPGFTVIGTAGtGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTA 82

                         90       100
                 ....*....|....*....|...
gi 549582276  84 RSDEVDRLLGLEIGADDYVAKPF 106
Cdd:cd19925   83 ANDVETVREALRLGVVDYLIKPF 105
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 49-115 2.11e-09

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 53.59  E-value: 2.11e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276  49 DAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:cd17573   44 DLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNPKTEQEIEAFKEGADDYIAKPFDFKVLVARI 110
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 6-105 4.65e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 52.38  E-value: 4.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEK---------ARQQRPDAVILDVGLPDISGFELCRqLLEHHPAL 76
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKlenlakegnDLSKELDLIITDIEMPKMDGYELTF-ELRDDPRL 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 549582276  77 ---PILFLTARSDEVDRLLGLEIGADDYVAKP 105
Cdd:cd19924   80 aniPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 8-118 6.04e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 52.42  E-value: 6.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVEL-FAR-GLPAL-------EKARQQRPDAVILDVGLPDISGFELCRQLLEHhPAL-- 76
Cdd:cd17557    4 LVEDNPGDAELIQEAFKEAGVPNELhVVRdGEEALdflrgegEYADAPRPDLILLDLNMPRMDGFEVLREIKAD-PDLrr 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 549582276  77 -PILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTL 118
Cdd:cd17557   83 iPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
PRK15347 PRK15347
two component system sensor kinase;
3-108 9.87e-09

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 55.03  E-value: 9.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   3 QPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFElCRQLLEHHPA-----LP 77
Cdd:PRK15347 690 QLQILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLE-TTQLWRDDPNnldpdCM 768

                         90       100       110
                 ....*....|....*....|....*....|...
gi 549582276  78 ILFLTAR--SDEVDRLlgLEIGADDYVAKPFSP 108
Cdd:PRK15347 769 IVALTANaaPEEIHRC--KKAGMNHYLTKPVTL 799
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 6-115 1.26e-08

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 51.32  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd19922    1 ILLLEKERNLAHFLSLELQKEGYRVDLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKLSRIKPASVIIVLDHWE 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:cd19922   81 DLQEELEEVQRFAVSYVVKPVLISNLVDKI 110
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 36-133 1.93e-08

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 53.26  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   36 GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLE-HHPALP-ILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSA 113
Cdd:TIGR02875  37 GVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNEiELSARPrVIMLSAFGQEKITQRAVALGADYYVLKPFDLEILAA 116

                          90       100
                  ....*....|....*....|.
gi 549582276  114 RVRTLL-RRVKKFAAPSPVVR 133
Cdd:TIGR02875 117 RIRQLAwGTNADILADSPTVP 137
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-119 2.37e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 50.80  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFT-VELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHH--PALPILFLT 82
Cdd:cd19923    3 VLVVDDFSTMRRIIKNLLKELGFNnVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGalSHLPVLMVT 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 549582276  83 ARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:cd19923   83 AEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 1-113 2.61e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 53.79  E-value: 2.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQP--QVWLVEDeqgIA-DTLIYTLQLE--GFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPA 75
Cdd:PRK11091 521 MPLPalNILLVED---IElNVIVARSVLEklGNSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPR 597

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 549582276  76 ---LPILFLTA--RSDEVDRllgLEIGADDYVAKPFSPREVSA 113
Cdd:PRK11091 598 edlPPLVALTAnvLKDKKEY---LDAGMDDVLSKPLSVPALTA 637
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 8-121 2.87e-08

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 50.66  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLE-GFTV-ELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLlehhpalpilfLTARS 85
Cdd:COG2197    6 IVDDHPLVREGLRALLEAEpDIEVvGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL-----------LTPRE 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 549582276  86 DEVDRLL--GL---EIGADDYVakpfSPREVSARVRTLLRR 121
Cdd:COG2197   75 REVLRLLaeGLsnkEIAERLGI----SERTVKTHVSNILRK 111
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 23-110 3.28e-08

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 50.32  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  23 LQLEGFTVELFARGLPALEKARQQRP--DAVILDVGLPDISGFELCrQLLEHHPALPILFLTARSDEVDRLLGLEIGADD 100
Cdd:cd17584   18 LLRCGYQVTTCTDAEEALSMLRENKDefDLVITDVHMPDMDGFEFL-ELIRLEMDLPVIMMSADGSTSTVMKGLAHGACD 96

                         90
                 ....*....|
gi 549582276 101 YVAKPFSPRE 110
Cdd:cd17584   97 YLLKPVSIED 106
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
131-226 4.59e-08

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 49.52  E-value: 4.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276 131 VVRTGHFELNEPAAQIAWFGTPLSLTRYEFLLLKTLLLSPERVYSRQQLMDIVWSDAQETfDRTVDTHIKTLRAKLRAIN 210
Cdd:COG3710    2 RYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVS-DNSLTQAISRLRKALGDDG 80

                         90
                 ....*....|....*.
gi 549582276 211 PDLSPINTHRGMGYSL 226
Cdd:COG3710   81 LEPRLIRTVPRRGYRL 96
PRK13435 PRK13435
response regulator; Provisional
 1-131 5.10e-08

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 50.44  E-value: 5.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWLVEDEQGIADTLIYTLQLEGFTVELFARGL-PALEKARQQRPDAVILDVGLPD-ISGFELCRQLLEHHpALPI 78
Cdd:PRK13435   3 LRQLKVLIVEDEALIALELEKLVEEAGHEVVGIAMSSeQAIALGRRRQPDVALVDVHLADgPTGVEVARRLSADG-GVEV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 549582276  79 LFLTArsdEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRVKKFAAPSPV 131
Cdd:PRK13435  82 VFMTG---NPERVPHDFAGALGVIAKPYSPRGVARALSYLSARRVGDRASGPT 131
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 23-115 5.98e-08

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 49.82  E-value: 5.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  23 LQLEGFTVELFARGLPALEKArQQRPDA--VILDVGLPDISGFELCRQLLEHHP--ALPILFLTARSDevdRLLG---LE 95
Cdd:cd17544   20 LRRHNFQVLEAANGQEALEVL-EQHPDIklVITDYNMPEMDGFELVREIRKKYSrdQLAIIGISASGD---NALSarfIK 95

                         90       100
                 ....*....|....*....|
gi 549582276  96 IGADDYVAKPFSPREVSARV 115
Cdd:cd17544   96 AGANDFLTKPFLPEEFYCRV 115
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 4-115 8.00e-08

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 49.17  E-value: 8.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQLEGFTVELFARG-LPALEKARQQRPDAVILDVGLPD-ISGFELCRQLLEHHPAlPILFL 81
Cdd:cd17540    1 TRVLIIEDEPLIAMDLEQIVEDLGHQVVGIARTrDEAVALARRERPDLILADIQLADgSSGIDAVNEILTTHDV-PVIFV 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 549582276  82 TARSdevDRLL-GLEIGADDYVAKPFSPREVSARV 115
Cdd:cd17540   80 TAYP---ERLLtGERPEPTFLITKPFDPEMVKAAI 111
PRK10693 PRK10693
two-component system response regulator RssB;
36-105 1.13e-07

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 51.14  E-value: 1.13e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549582276  36 GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSD--EVDRLLGLeiGADDYVAKP 105
Cdd:PRK10693   6 GVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENmaDIAKALRL--GVQDVLLKP 75
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 6-105 1.57e-07

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 47.92  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELfARGLP-ALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTAR 84
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRS-ARNVKeARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAY 79

                         90       100
                 ....*....|....*....|.
gi 549582276  85 SDEVDRLLGLEIGADDYVAKP 105
Cdd:cd19926   80 GSLDTAIEALKAGAFDFLTKP 100
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 6-106 2.20e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 47.73  E-value: 2.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEK-ARQQRPDAVILDVGLPD-ISGFELCRQLLEHHPALPILFLTA 83
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLlESGPDIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLTSG 80

                         90       100
                 ....*....|....*....|...
gi 549582276  84 RSDEVDRLLGLEIGAdDYVAKPF 106
Cdd:cd18161   81 YAENAIEGGDLAPGV-DVLSKPF 102
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 19-105 1.44e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 48.31  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  19 LIYTL---QLEgfTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPALPILFLTAR--SDEVDRL 91
Cdd:PRK11107 682 LIGALleeQVE--HVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIrqLPHNQNTPIIAVTAHamAGERERL 759

                         90
                 ....*....|....
gi 549582276  92 LGLeiGADDYVAKP 105
Cdd:PRK11107 760 LSA--GMDDYLAKP 771
PRK15115 PRK15115
response regulator GlrR; Provisional
 8-105 2.34e-06

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 47.52  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDE 87
Cdd:PRK15115  10 LVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAHGSI 89

                         90
                 ....*....|....*...
gi 549582276  88 VDRLLGLEIGADDYVAKP 105
Cdd:PRK15115  90 PDAVAATQQGVFSFLTKP 107
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 6-105 2.60e-06

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 44.80  E-value: 2.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARS 85
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQN 80

                         90       100
                 ....*....|....*....|
gi 549582276  86 DEVDRLLGLEIGADDYVAKP 105
Cdd:cd19928   81 TLMTAVKAAERGAFEYLPKP 100
PRK13557 PRK13557
histidine kinase; Provisional
 6-119 3.15e-06

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 47.36  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQ-RPDAVILDVGLP-DISGFELCRQLLEHHPALPILFLTA 83
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHpEVDLLFTDLIMPgGMNGVMLAREARRRQPKIKVLLTTG 497

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 549582276  84 RSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLL 119
Cdd:PRK13557 498 YAEASIERTDAGGSEFDILNKPYRRAELARRVRMVL 533
PRK11697 PRK11697
two-component system response regulator BtsR;
8-131 3.16e-06

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 46.38  E-value: 3.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGfTVELF---ARGLPALEKARQQRPDAVILDVGLPDISGFELCRQL-LEHHPAlpILFLTA 83
Cdd:PRK11697   6 IVDDEPLAREELRELLQEEG-DIEIVgecSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLdPEHMPY--IVFVTA 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 549582276  84 rSDEVdRLLGLEIGADDYVAKPFSPrevsARVRTLLRRVKKFAAPSPV 131
Cdd:PRK11697  83 -FDEY-AIKAFEEHAFDYLLKPIDP----ARLAKTLARLRQERSPQDV 124
PRK10610 PRK10610
chemotaxis protein CheY;
7-107 3.28e-06

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 44.97  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   7 WLVEDEQGIADTLIYTLQLE-GF-TVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHH--PALPILFLT 82
Cdd:PRK10610   8 FLVVDDFSTMRRIVRNLLKElGFnNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGamSALPVLMVT 87

                         90       100
                 ....*....|....*....|....*
gi 549582276  83 ARSDEVDRLLGLEIGADDYVAKPFS 107
Cdd:PRK10610  88 AEAKKENIIAAAQAGASGYVVKPFT 112
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 4-120 3.40e-06

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 44.70  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQLEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHP-ALPILfLT 82
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPdTVRIL-LT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 549582276  83 ARSD-----------EVDRllgleigaddYVAKPFSPREVSARVRTLLR 120
Cdd:cd17569   80 GYADldaaieainegEIYR----------FLTKPWDDEELKETIRQALE 118
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 30-119 5.85e-06

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 44.53  E-value: 5.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  30 VELFARGLPALEKARQQRPDAV-ILDV--GLPDISGFELCRQLLEHHPALPILFLTARSDEVdrLLGLE--IGADDYVAK 104
Cdd:cd17533   33 IELTGKTEELLEKIKERGKNGIyFLDIdiKMEEKNGLEVAQKIRKYDPYAIIIFVTTHSEFA--PLTFEykVAALDFILK 110

                         90
                 ....*....|....*
gi 549582276 105 PFSPREVSARVRTLL 119
Cdd:cd17533  111 PLKLEEFKKRIEECI 125
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 8-115 6.94e-06

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 43.79  E-value: 6.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEGFT-VELFARGLPALEKARQQRPDAVILDVGLPD-ISGfelcRQLLE---HHPALP----I 78
Cdd:cd17589    3 IVDDQPTFRSMLKSMLRSLGVTrIDTASSGEEALRMCENKTYDIVLCDYNLGKgKNG----QQLLEelrHKKLISpstvF 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 549582276  79 LFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:cd17589   79 IMVTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 34-110 1.50e-05

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 44.25  E-value: 1.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276  34 ARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPRE 110
Cdd:PRK10651  39 SNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPED 115
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 4-120 1.64e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 43.12  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   4 PQVWLVEDEQGIADTLIYTLQlEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTA 83
Cdd:cd17596    1 PTILVVDDEVRSLEALRRTLE-EDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIISG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 549582276  84 RSDEVDRLLGL-EIGADDYVAKPFSPREVSARVRTLLR 120
Cdd:cd17596   80 YTDSEDIIAGInEAGIYQYLTKPWHPDQLLLTVRNAAR 117
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-107 1.70e-05

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 44.24  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   1 MQQPQVWL-VEDEQGIADTLI-YTLQLEGFTVELFARGLP-ALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALP 77
Cdd:PRK10046   1 MTAPLTLLiVEDETPLAEMHAeYIRHIPGFSQILLAGNLAqARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGD 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 549582276  78 ILFLTARSDEVDRLLGLEIGADDYVAKPFS 107
Cdd:PRK10046  81 VVFTTAASDMETVSEAVRCGVFDYLIKPIA 110
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 36-110 2.40e-05

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 42.33  E-value: 2.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549582276  36 GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPRE 110
Cdd:cd19931   33 GEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTVSDAEDDVVTALRAGADGYLLKDMEPED 107
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 32-122 2.44e-05

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 42.14  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  32 LFAR-GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTA--RSDEVDRLLGLeiGADDYVAKPFSP 108
Cdd:cd17593   29 TFAEnGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVSGdvQPEAKERVLEL--GALAFLKKPFDP 106

                         90
                 ....*....|....
gi 549582276 109 revsARVRTLLRRV 122
Cdd:cd17593  107 ----EKLAQLLEEL 116
PRK09483 PRK09483
response regulator; Provisional
 36-117 7.28e-05

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 42.40  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  36 GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:PRK09483  36 GEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAI 115


                 ..
gi 549582276 116 RT 117
Cdd:PRK09483 116 RS 117
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 39-116 3.32e-04

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 39.31  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  39 ALEKARQQRPDAVILDVGLPDISGFELCRQLlEHHPA---LPILFLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:cd17575   37 AIEVASQIKPTVILQDLVMPGVDGLTLVRFF-RANPAtrdIPIIVLSTKEEPEVKSEAFALGANDYLVKLPDKIELVARI 115


                 .
gi 549582276 116 R 116
Cdd:cd17575  116 R 116
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
36-104 4.72e-04

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 39.88  E-value: 4.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549582276  36 GLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAK 104
Cdd:PRK09958  34 GGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSK 102
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 6-119 8.41e-04

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 37.83  E-value: 8.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLEGFT-VELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHhpALPILFLTAR 84
Cdd:cd17586    1 VLVLEDEPLIAMNLEDALEDLGGKeVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRR--AIPFIFATGY 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 549582276  85 SD---EVDRLLGLEIgaddyVAKPFSPREVSARVRTLL 119
Cdd:cd17586   79 GDshgIDSRLIDVPV-----LRKPFDADSALAALAMLL 111
PRK10360 PRK10360
transcriptional regulator UhpA;
8-118 1.27e-03

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 38.42  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   8 LVEDEQGIADTLIYTLQLEG--FTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEhhpALPILFLTARS 85
Cdd:PRK10360   6 LIDDHLIVRSGFAQLLGLEPdlQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPK---GMATIMLSVHD 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 549582276  86 DEVDRLLGLEIGADDYVAKPFSPREVSARVRTL 118
Cdd:PRK10360  83 SPALVEQALNAGARGFLSKRCSPDELIAAVHTV 115
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 6-113 1.37e-03

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 37.42  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQ-LEGFTVELFARGLPALEKARQQRPDAVILDVGLPDISGFELCRQLLEHH-PALPILF--L 81
Cdd:cd17530    3 VLVLDDDPFQCMMAATILEdLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHsNAAVILMsgL 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 549582276  82 TARSDEVDRLLGLEIGAD--DYVAKPFSPREVSA 113
Cdd:cd17530   83 DGGILESAETLAGANGLNllGTLSKPFSPEELTE 116
PRK09191 PRK09191
two-component response regulator; Provisional
 39-113 4.14e-03

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 37.52  E-value: 4.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549582276  39 ALEKARQQRPDAVILDVGLPD-ISGFELCRQLLEHHPaLPILFLTARSdevDRLLGLEIGADDY-VAKPFSPREVSA 113
Cdd:PRK09191 174 AVALAKKTRPGLILADIQLADgSSGIDAVNDILKTFD-VPVIFITAFP---ERLLTGERPEPAFlITKPFQPDTVKA 246
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 36-106 4.97e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 35.66  E-value: 4.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549582276  36 GLPALEKARQQRPDAVILDVGLPDISGF----ELCRQLLEHHPAlpILFLTARSDEVDRLLGLEIGADDYVAKPF 106
Cdd:cd17561   36 GQEALELIEEKEPDVLLLDIIMPHLDGIgvleKLRRMRLEKRPK--IIMLTAFGQEDITQRAVELGASYYILKPF 108
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 51-107 5.50e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 35.84  E-value: 5.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549582276  51 VILDVGLPDISGFELCRQLLE----HHPALpILFLTARSDEVDRLLGLEIGADDYVAKPFS 107
Cdd:cd19933   50 VLLDLCMPEMDGFEVALRIRKlfgrRERPL-IVALTANTDDSTREKCLSLGMNGVITKPVS 109
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
39-104 6.89e-03

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 36.39  E-value: 6.89e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 549582276  39 ALEKARQQRPDAVILDVGLPDISGFELCRQLLEHHPALPILFLTARSDEVDRLLGLEIGADDYVAK 104
Cdd:PRK09935  41 TIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSKSECFYAGRAIQAGANGFVSK 106
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-104 6.98e-03

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 35.23  E-value: 6.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276   6 VWLVEDEQGIADTLIYTLQLE-GFTVELFArglpALEKARQ---QRPD--AVILDVGLPDISGFELCRQLLEHHpaLPIL 79
Cdd:cd19921    2 VLIVEDSKTFSKVLKHLIAQElGLEVDVAE----TLAEAKAlleEGDDyfAALVDLNLPDAPNGEAVDLVLEKG--IPVI 75

                         90       100
                 ....*....|....*....|....*
gi 549582276  80 FLTARSDEVDRLLGLEIGADDYVAK 104
Cdd:cd19921   76 VLTGSFDEDKRETLLSKGVVDYVLK 100
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
43-133 7.17e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 37.35  E-value: 7.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549582276  43 ARQQRPDAVILDVGLPDISGfeLCRQLLEHHPALPILfLTARSDEVDRLLGLEIGADDYVAKPFSPREVSARVRTLLRRV 122
Cdd:PRK13837 739 KGPERFDLVLVDDRLLDEEQ--AAAALHAAAPTLPII-LGGNSKTMALSPDLLASVAEILAKPISSRTLAYALRTALATA 815

                         90
                 ....*....|.
gi 549582276 123 KKFAAPSPVVR 133
Cdd:PRK13837 816 RAAAARAEGTP 826
PRK14084 PRK14084
DNA-binding response regulator;
40-115 7.54e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 36.65  E-value: 7.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549582276  40 LEKARQQRPDAVILDVGLPDISGFELCRQL--LEHHPAlpILFLTARsdEVDRLLGLEIGADDYVAKPFSPREVSARV 115
Cdd:PRK14084  39 LEALLINQYDIIFLDINLMDESGIELAAKIqkMKEPPA--IIFATAH--DQFAVKAFELNATDYILKPFEQKRIEQAV 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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