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Conserved domains on  [gi|552147920|gb|ERU13390|]
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hypothetical protein P035_01003 [Brucella suis 06-988-1656]

Protein Classification

SH3 domain-containing protein( domain architecture ID 11471995)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

CATH:  2.30.30.40
Gene Ontology:  GO:0005515|GO:0070064
PubMed:  28510178|11256992|1639195
SCOP:  4000369

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
28-92 5.90e-24

Uncharacterized conserved protein YraI [Function unknown];


:

Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 89.74  E-value: 5.90e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 552147920  28 TTNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSGYGWCQVNYGNMFGWASSRYLAMREGSASGYS 92
Cdd:COG4991   28 TDDLNLRSGPGTGYPVVGTLPAGATVTVLGCTSGGGWCKVSYGGQRGWVSARYLQVSYDGQPVPL 92
 
Name Accession Description Interval E-value
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
28-92 5.90e-24

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 89.74  E-value: 5.90e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 552147920  28 TTNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSGYGWCQVNYGNMFGWASSRYLAMREGSASGYS 92
Cdd:COG4991   28 TDDLNLRSGPGTGYPVVGTLPAGATVTVLGCTSGGGWCKVSYGGQRGWVSARYLQVSYDGQPVPL 92
SH3_3 pfam08239
Bacterial SH3 domain;
29-82 9.97e-11

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 54.18  E-value: 9.97e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 552147920   29 TNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSGyGWCQV-NYGNMFGWASSRYLA 82
Cdd:pfam08239   1 SGLNVRSGPSTSSEVVGTLPKGEKVEVLEEQGG-GWYKVrTYDGYEGWVSSSYLS 54
SH3_and_anchor TIGR04211
SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved ...
 32-89 4.04e-06

SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.


Pssm-ID: 275056 [Multi-domain]  Cd Length: 198  Bit Score: 45.00  E-value: 4.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 552147920   32 NVRTGPGTGYAAVGAIPSGAPVNVRGcTSGYGWCQVNYGN-MFGWASSRYLaMREGSAS 89
Cdd:TIGR04211   9 YMRSGPGNQYRILGSLKSGTPVTVLE-RSEDGYSRVRTPKgREGWVLSRYL-SDTPSAR 65
SH3b smart00287
Bacterial SH3 domain homologues;
29-71 3.23e-04

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 37.31  E-value: 3.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 552147920    29 TNLNVRTGPGTGYAAVGAIPSGAPVNVrGCTSGYGWCQVNYGN 71
Cdd:smart00287   9 DGLNVRTGPGTSSPIIGTLKKGDKVKV-LGVDGQDWAKITYGS 50
PRK13914 PRK13914
invasion associated endopeptidase;
29-88 3.15e-03

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 37.09  E-value: 3.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552147920  29 TNLNVRTGPGTGYAAVGAIPSGAPVNVRgCTSGYGWCQVNYGN-MFGWASSRYLAMREGSA 88
Cdd:PRK13914  87 TWLNVRSGAGVDNSIITSIKGGTKVTVE-TTESNGWHKITYNDgKTGFVNGKYLTDKVTST 146
 
Name Accession Description Interval E-value
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
28-92 5.90e-24

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 89.74  E-value: 5.90e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 552147920  28 TTNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSGYGWCQVNYGNMFGWASSRYLAMREGSASGYS 92
Cdd:COG4991   28 TDDLNLRSGPGTGYPVVGTLPAGATVTVLGCTSGGGWCKVSYGGQRGWVSARYLQVSYDGQPVPL 92
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 28-82 1.54e-11

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 58.21  E-value: 1.54e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 552147920  28 TTNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSgyGWCQVNYGN-MFGWASSRYLA 82
Cdd:COG3103   11 ADALNVRSGPGTSYRIVGTLPKGEKVTVLGRSG--GWYKVRYSNgKTGWVSSRYLT 64
SH3_3 pfam08239
Bacterial SH3 domain;
29-82 9.97e-11

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 54.18  E-value: 9.97e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 552147920   29 TNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSGyGWCQV-NYGNMFGWASSRYLA 82
Cdd:pfam08239   1 SGLNVRSGPSTSSEVVGTLPKGEKVEVLEEQGG-GWYKVrTYDGYEGWVSSSYLS 54
SH3_and_anchor TIGR04211
SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved ...
 32-89 4.04e-06

SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.


Pssm-ID: 275056 [Multi-domain]  Cd Length: 198  Bit Score: 45.00  E-value: 4.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 552147920   32 NVRTGPGTGYAAVGAIPSGAPVNVRGcTSGYGWCQVNYGN-MFGWASSRYLaMREGSAS 89
Cdd:TIGR04211   9 YMRSGPGNQYRILGSLKSGTPVTVLE-RSEDGYSRVRTPKgREGWVLSRYL-SDTPSAR 65
SH3b smart00287
Bacterial SH3 domain homologues;
29-71 3.23e-04

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 37.31  E-value: 3.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 552147920    29 TNLNVRTGPGTGYAAVGAIPSGAPVNVrGCTSGYGWCQVNYGN 71
Cdd:smart00287   9 DGLNVRTGPGTSSPIIGTLKKGDKVKV-LGVDGQDWAKITYGS 50
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 28-76 1.39e-03

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 36.64  E-value: 1.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 552147920  28 TTNLNVRTGPGTGYAAVGAIPSGAPVNVRGCTSgyGWCQVNYGNmFGWA 76
Cdd:COG3103   74 PDELNLRAGPSTSSEVLGLLPKGETVTVLKKSG--GWFKVGYRG-TGWV 119
PRK13914 PRK13914
invasion associated endopeptidase;
29-88 3.15e-03

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 37.09  E-value: 3.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552147920  29 TNLNVRTGPGTGYAAVGAIPSGAPVNVRgCTSGYGWCQVNYGN-MFGWASSRYLAMREGSA 88
Cdd:PRK13914  87 TWLNVRSGAGVDNSIITSIKGGTKVTVE-TTESNGWHKITYNDgKTGFVNGKYLTDKVTST 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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