|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
1-389 |
0e+00 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 798.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 1 MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSA 80
Cdd:PRK05967 1 MAKKQLKTEKAGINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAETMATRGQKYTYGTRGTPTTDALCKAIDALEGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 81 GTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPAS 160
Cdd:PRK05967 81 GTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 161 NTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM 240
Cdd:PRK05967 161 NTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQLLEAHGTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 241 GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKG-- 318
Cdd:PRK05967 241 GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGpe 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552147923 319 -GHAQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK05967 321 kGKAKAHAFLDALEIFGLGYSWGGYESLALHVKLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGFAAA 392
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
15-389 |
0e+00 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 560.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 15 TRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITV 94
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDSHAAQRRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 95 PLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEA 174
Cdd:TIGR01324 81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 175 AHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMGLCAGPDDTYQILR 254
Cdd:TIGR01324 161 ARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLREHSYLMGQMVDADDAYTTLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 255 GLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGHAQASAFLNALEIFG 334
Cdd:TIGR01324 241 GLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQVHAFLDHLQLFG 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 552147923 335 LGYSWGGYQSLALEV--KLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:TIGR01324 321 LGYSWGGYESLALCNqpELGHRPNIKRNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
11-389 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 534.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 11 LGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQK----YTYGTRGTPTSEALCKAIDALEGSAGTVCVP 86
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGeeggYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 87 SGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQ 166
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 167 DIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTN-EKCWPQLLETHGTMGLCAG 245
Cdd:COG0626 161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRdEELAERLRFLQNALGAVLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 246 PDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASA 325
Cdd:COG0626 241 PFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFEL-KGGREAARR 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 326 FLNALEIFGLGYSWGGYQSLALEVKL-GDRTVSKNDYA-----GPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:COG0626 320 FLDALKLFTLAVSLGGVESLITHPATmTHRSLPPEERAalgitDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
29-387 |
5.37e-164 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 464.98 E-value: 5.37e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 29 GFVNPPVVRASTVLFPDAETM------ASNGQKYtYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSP 102
Cdd:PRK09028 21 GVINPPVFRASTVVFDTVAEMrhaaknRANGEMF-YGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 103 GDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIV 182
Cdd:PRK09028 100 GDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 183 MMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIR 262
Cdd:PRK09028 180 MLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 263 LEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGHAQASAFLNALEIFGLGYSWGGY 342
Cdd:PRK09028 260 LAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKQGDPKAVTALVEGMQHFKMGFSWGGF 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 552147923 343 QSLALEVKLGD--RTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFA 387
Cdd:PRK09028 340 ESLILGVFGINklRTATNWDFSKPLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
13-389 |
1.41e-147 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 423.35 E-value: 1.41e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 13 INTRLAHDGYCPGDYHGFVNPPVVRASTVLFpdaETMAS---------NGQKYtYGTRGTPTSEALCKAIDALEGSAGTV 83
Cdd:PRK08114 6 LDTQLVNAGRSKKYTQGSVNSVIQRASSLVF---DSVEAkkhatrnraNGELF-YGRRGTLTHFSLQEAMCELEGGAGCA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 84 CVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTF 163
Cdd:PRK08114 82 LYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 164 EIQDIPAIAEAAHKGN--AIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMG 241
Cdd:PRK08114 162 EVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQLRENSYLMG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 242 LCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKG-GH 320
Cdd:PRK08114 242 QMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKKlTD 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 552147923 321 AQASAFLNALEIFGLGYSWGGYQSLAL----EVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK08114 322 EQLANYLDNFSLFSMAYSWGGFESLILanqpEEIAAIRPAGEVDFTGTLIRLHIGLEDVDDLIADLAAGFARI 394
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
7-389 |
4.31e-147 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 422.21 E-value: 4.31e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 7 KTEKLGINTRLAH-DGYCPGDYHGFVnPPVVRASTVLFPDAETMASNGQK----YTYGTRGTPTSEALCKAIDALEGSAG 81
Cdd:PRK07050 4 STPKRALQTRIVQpDDQIPPGFRSFV-TPVARASTVVFPDLATMRALDWRqdvqWRYGLHATPTSLALAQRLAEIEGGRH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 82 TVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASN 161
Cdd:PRK07050 83 ALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 162 TFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTIST-NEKCWPQLLETHGTM 240
Cdd:PRK07050 163 TMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITaDAELHAKLKLARMRL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 241 GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVL-AKGG 319
Cdd:PRK07050 243 GIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFdERYS 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 320 HAQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK07050 323 PAQVDAFVEALELFAIGWSWGGACSLAMPYDVASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
31-387 |
5.19e-140 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 403.12 E-value: 5.19e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 31 VNPPVVRASTVLFPDAETMASN----GQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHA 106
Cdd:cd00614 3 VAPPIYQTSTFVFPSPAEAADLfalrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 107 LLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDN 186
Cdd:cd00614 83 VASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 187 TWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTN-EKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIRLEH 265
Cdd:cd00614 163 TFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSgEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMER 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 266 HRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSL 345
Cdd:cd00614 243 HSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFEL-KGGLEAAKKFLNALKLFSLAVSLGGVESL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 552147923 346 A-LEVKLGDRTVSKNDYAGP-----VIRLQIGLEDVPDLIADLERGFA 387
Cdd:cd00614 322 VeHPASMTHSQLPPEERAAAgitpgLVRLSVGIEDVEDLIADLEQALK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
15-387 |
7.19e-133 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 385.43 E-value: 7.19e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 15 TRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAEtmasNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITV 94
Cdd:pfam01053 2 TLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAG----EEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 95 PLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEA 174
Cdd:pfam01053 78 AILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 175 AHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLET-HGTMGLCAGPDDTYQIL 253
Cdd:pfam01053 158 AKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFlQNATGAVLSPFDAWLLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 254 RGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIF 333
Cdd:pfam01053 238 RGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFEL-KGGLEAAKKFLDNLKLF 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 552147923 334 GLGYSWGGYQSLAL------------EVKLgDRTVSKNdyagpVIRLQIGLEDVPDLIADLERGFA 387
Cdd:pfam01053 317 SLAVSLGGVESLIShpatmthasippEERE-AAGITDD-----LIRLSVGIEDVDDLIADLKQALE 376
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
8-389 |
5.71e-87 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 269.98 E-value: 5.71e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 8 TEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMAS--NGQK--YTYgTR-GTPTSEALCKAIDALEGSAGT 82
Cdd:COG2873 3 EKKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADlfALKEpgNIY-TRiMNPTTDVLEKRIAALEGGVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 83 VCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRH-FANTiLKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTES---P 158
Cdd:COG2873 82 LATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNlFAHT-LPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETignP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 159 ASNTFeiqDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTI--------STNEKcW 230
Cdd:COG2873 161 ALDVL---DIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwAANGK-F 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 231 PQLLET----HGT----------------------MGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVE 284
Cdd:COG2873 237 PELTEPdpsyHGLvyteafgnaafitkarvqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 285 RVLHPALESHPGHEIWKRDFS-GSSGIFSFVLaKGGHAQASAFLNALEIFglgyswggyqslALEVKLGD-RT------- 355
Cdd:COG2873 317 WVNYPGLPSHPYHELAQKYLPkGAGGVLTFGL-KGGREAGKKFIDSLKLF------------SHLANIGDaKSlvihpas 383
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 552147923 356 ---------------VSKNdyagpVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:COG2873 384 tthsqlseeeqaaagVTPD-----LIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
7-388 |
1.74e-86 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 267.28 E-value: 1.74e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 7 KTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTvlfpdaetMASNG-----QKYTYGTRGTPTSEALCKAIDALEGSAG 81
Cdd:PRK07811 7 HHANQGFATRAIHAGYEPDPATGAVNPPIYASST--------FAQDGvgglrGGYEYARTGNPTRTALEEQLAALEGGAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 82 TVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDveyYDPEIGADIAKL---MRPNTKVVFTESP 158
Cdd:PRK07811 79 GRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVE---YTPVDLSDLDAVraaITPRTKLIWVETP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 159 ASNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEkcwPQLLET-- 236
Cdd:PRK07811 156 TNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTND---EELDEAfa 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 237 --HGTMGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFV 314
Cdd:PRK07811 233 flQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVR 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 552147923 315 LAkGGHAQASAFLNALEIFGLGYSWGGYQSLaLEV--KLGDRTVSKNDYAGP--VIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK07811 313 LA-GGEEAARDFCARTKVFTLAESLGGVESL-IEHpsAMTHASTAGSQLEVPddLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
17-388 |
4.23e-86 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 266.56 E-value: 4.23e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 17 LAHDGYCPGDYhgfVNPPVVRASTVLFPD----AETMASNGQKYTYgTRG-TPTSEALCKAIDALEGSAGTVCVPSGLAA 91
Cdd:PRK05968 15 TAHDEGNAFDA---VVPPIFQTSLFTFDSydemEDVYAGEKVRPIY-SRGdNPTVRAFEEMLAKLEGAEDARGFASGMAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 92 ITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMrPNTKVVFTESPASNTFEIQDIPAI 171
Cdd:PRK05968 91 ISSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 172 AEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTIS--------TNEKCWPQLlethgtmGLC 243
Cdd:PRK05968 170 AALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAgskehiarINAEAYPYL-------GAK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 244 AGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPgheiwKRDFSGSSGIFSFVLAKGGHAQa 323
Cdd:PRK05968 243 LSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP-----PAGLSGTSGLFSFIFREGIDVR- 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552147923 324 sAFLNALEIFGLGYSWGGYQSL------ALEVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK05968 317 -AFADALKLFRLGVSWGGHESLvvpaevVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAA 386
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
10-389 |
2.09e-81 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 254.43 E-value: 2.09e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 10 KLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAET----MASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCV 85
Cdd:TIGR01328 1 RMTFATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQggnrFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 86 PSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEI 165
Cdd:TIGR01328 81 SSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 166 QDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLET--HGTMGLC 243
Cdd:TIGR01328 161 IDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQIRMVgiKDMTGSV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 244 AGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQA 323
Cdd:TIGR01328 241 ISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFEL-KGGFAGA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552147923 324 SAFLNALEIFGLGYSWGGYQSLALE-VKLGDRTVSKNDYAGP-----VIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:TIGR01328 320 KKLLNNLKLIRLAVSLGDAETLIQHpASMTHAVVPKEEREAAgitdgMIRLSVGLEDADDLIADLKQALDAL 391
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
9-389 |
8.89e-77 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 242.81 E-value: 8.89e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 9 EKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAET----MASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVC 84
Cdd:PRK06234 5 KKMGFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQggrrFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 85 VPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFE 164
Cdd:PRK06234 85 AASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 165 IQDIPAIAEAAHKGN--AIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQ--LLETHGTM 240
Cdd:PRK06234 165 VTDIKAISNIAHENNkeCLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQvkLFGIKDMT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 241 GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGH 320
Cdd:PRK06234 245 GSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFEL-KGGV 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 552147923 321 AQASAFLNALEIFGLGYSWGGYQSLALE--------VKLGDRTVSknDYAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK06234 324 EEGKVVMNNVKLATLAVSLGDAETLIQHpasmthspYTAEERKEA--GISDGLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
15-387 |
1.88e-76 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 241.17 E-value: 1.88e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 15 TRLAHDGyCPGDYH-GFVNPPVVRASTVLFPDAetmasnGQK--YTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAA 91
Cdd:PRK07671 5 TKLIHGG-IIGDPStGAVSVPIYQVSTYKQEAV------GKHqgYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 92 ITVPLLGFLSpGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAI 171
Cdd:PRK07671 78 ITAVMMLFSS-GDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 172 AEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEkcwPQLLE----THGTMGLCAGPD 247
Cdd:PRK07671 157 STIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNS---PELAEdlhfVQNSTGGILGPQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 248 DTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGHAQasAFL 327
Cdd:PRK07671 234 DSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDVGSEETAN--KVL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 552147923 328 NALEIFGLGYSWGGYQSL-ALEVKLGDRTVSKNDYA-----GPVIRLQIGLEDVPDLIADLERGFA 387
Cdd:PRK07671 312 ERLQYFTLAESLGAVESLiSIPSQMTHASIPADRRKelgitDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
13-389 |
2.73e-76 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 240.96 E-value: 2.73e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 13 INTRLAHDGYCPGDYHGFVNPPVVRASTVlfpdAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAI 92
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTSTY----RQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 93 TVpLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIA 172
Cdd:PRK06176 79 HA-VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 173 EAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLE-THGTMGLCAGPDDTYQ 251
Cdd:PRK06176 158 SVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAfFQNAIGGVLGPQDSWL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 252 ILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKggHAQASAFLNALE 331
Cdd:PRK06176 238 LQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKN--DSEAVAFVESLK 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 552147923 332 IFGLGYSWGGYQSL-ALEVKLGDRTVSK--NDYAG---PVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK06176 316 LFILGESLGGVESLvGIPAFMTHACIPKeqREAAGirdGLVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
8-389 |
6.94e-76 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 240.06 E-value: 6.94e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 8 TEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMAsngqKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPS 87
Cdd:PRK08064 2 AMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFG----KYDYSRSGNPTREALEDIIAELEGGTKGFAFAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 88 GLAAITVPLLgFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQD 167
Cdd:PRK08064 78 GMAAISTAFL-LLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 168 IPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTIST-NEKCWPQLLETHGTMGLCAGP 246
Cdd:PRK08064 157 IRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVkDEELAQKLYFLQNSFGAVLGV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 247 DDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKggHAQASAF 326
Cdd:PRK08064 237 QDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQS--EEAVRQF 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 552147923 327 LNALEIFGLGYSWGGYQS-LALEVKLGDRTVSKND-----YAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK08064 315 VSHVKLPVFAVSLGAVESiLSYPAKMSHAAMPKEErdergITDGLLRLSVGLENVDDLIADFEQALSYV 383
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
7-388 |
3.22e-75 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 238.93 E-value: 3.22e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 7 KTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAE----TMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGT 82
Cdd:PRK07503 4 SHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEygaeCFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 83 VCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNT 162
Cdd:PRK07503 84 VALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 163 FEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQL-LETHGTM- 240
Cdd:PRK07503 164 MRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIrLEGLKDMt 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 241 GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGH 320
Cdd:PRK07503 244 GAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFEL-KGGI 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 552147923 321 AQASAFLNALEIFGLGYSWGGYQSLALE-VKLGDRTVSKNDYAGP-----VIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK07503 323 AAGRRFMNALQLFARAVSLGDAESLAQHpASMTHSTYTPEERAEHgisegLVRLSVGLEDVADILADLAQALDA 396
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
56-388 |
4.22e-73 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 232.97 E-value: 4.22e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 56 YTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYD 135
Cdd:PRK08133 53 NIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVD 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 136 PEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGH 215
Cdd:PRK08133 133 LTDLDAWRAAVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQ 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 216 SDILFGTISTNEKcwpQLLETHG---TMGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALE 292
Cdd:PRK08133 213 GRVLGGAVVGSKE---LMEEVFGflrTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLP 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 293 SHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIfglgyswggyqsLALEVKLGDR---------------TVS 357
Cdd:PRK08133 290 SHPQHELAKRQQKGGGAIVSFEV-KGGREAAWRVIDATRL------------ISITANLGDTkttithpattthgrlSPE 356
|
330 340 350
....*....|....*....|....*....|....
gi 552147923 358 KNDYAG---PVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK08133 357 ARAAAGiteGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
28-389 |
1.05e-72 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 232.32 E-value: 1.05e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 28 HGFVNPPVVRASTVLFPDA----ETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPG 103
Cdd:PRK08249 24 YGATQVPVVLSVAYGYDDIdewyDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYTFLKPG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 104 DHALLVDSIYYSTRHFANTILKRMGVDVEYYDP----EIGADIAKlmrpNTKVVFTESPASNTFEIQDIPAIAEAAHKGN 179
Cdd:PRK08249 104 DRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETgdheQIEAEIAK----GCDLLYLETPTNPTLKIVDIERLAAAAKKVG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 180 AIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMGLCAGPDDTYQILRGLRTM 259
Cdd:PRK08249 180 ALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQVYHYREINGATMDPMSAYLILRGMKTL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 260 GIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSW 339
Cdd:PRK08249 260 KLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVL-KGGMDTVKRLLPKLRYAHRAANL 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552147923 340 GgyqslALEVKLGD-RTVS-------KNDYAG---PVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK08249 339 G-----AVETIYGPaRTTShventleERAALGipeGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
28-389 |
2.01e-69 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 223.80 E-value: 2.01e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 28 HGFVNPPVVRASTVLFPDAETMAS--NGQK--YTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPG 103
Cdd:PRK05939 7 HGAVHKPIHTSVTYGYEDARDLIDvfQGKKpgFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 104 DHALLVDSIYYSTRHFANTiLKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVM 183
Cdd:PRK05939 87 DHLVSSQFLFGNTNSLFGT-LRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 184 MDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTIS-TNEKCW---PQLLETHGT------------------MG 241
Cdd:PRK05939 166 VDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdTGLFDWsayPNIFPAYRKgdpqqwgltqirkkglrdMG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 242 LCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGha 321
Cdd:PRK05939 246 ATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGI-- 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 552147923 322 QASAFLNALEIFGLGYSWGGYQSLALEV------KLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK05939 324 DCFDFLNRLKLVIKATHLGDTRTLVIPVaptiyyEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
17-389 |
3.85e-68 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 219.94 E-value: 3.85e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 17 LAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPL 96
Cdd:PRK08574 6 DAVRGYRGSDPYGSLQPPIYLTALFRQEGEAYPSDRGFDLKYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 97 LGFLSPGDHALLVDSIYYSTRHFANTiLKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAH 176
Cdd:PRK08574 86 FSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 177 KGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQ-LLETHGTMGLCAGPDDTYQILRG 255
Cdd:PRK08574 165 ELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEeLWEWRRRLGTIMQPFEAYLVLRG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 256 LRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGS--SGIFSFVLaKGGHAQASAFLNALEIF 333
Cdd:PRK08574 245 LKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDlyGGVVSFRV-KGGRDAVLKFLRSLKLI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552147923 334 GLGYSWGGYQSLA-LEVKLGDRTVSKNDYAG-----PVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK08574 324 KPSPSLGGVESLAtYPVKSAASPIPEEDRKAlgiteDLVRLSVGLEDVEDLIEDLDQALGSI 385
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
12-389 |
5.06e-68 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 219.10 E-value: 5.06e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 12 GINTRLAHDGYCPGDYHGFVNPPVVRAST-VLFPDAETMAsngqkYTYGTRGTPTSEALCKAIDALEGsAGTVCVPSGLA 90
Cdd:PRK07582 3 GDGTRSVHAGGPEAVPGEPVLPGPVFAAPyHLSPGEPTGP-----DTYGRASNPTWRALEAALGELEG-AEALVFPSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 91 AITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYY-DPEIGADIAKlmrpNTKVVFTESPASNTFEIQDIP 169
Cdd:PRK07582 77 AITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREApTAGMAEAALA----GADLVLAETPSNPGLDVCDLA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 170 AIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEkcwPQLLE------THgtMGLC 243
Cdd:PRK07582 153 ALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRD---PELMAaverwrLL--AGAI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 244 AGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAkgGHAQA 323
Cdd:PRK07582 228 PGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELA--DAAAA 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 552147923 324 SAFLNALEIFGLGYSWGGYQSLAlevklgDRTVSKNDYAGP-VIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK07582 306 ERFVAASRLVVAATSFGGVHTSA------DRRARWGDAVPEgFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
24-388 |
1.26e-67 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 218.54 E-value: 1.26e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 24 PGDYHGFVNPPVVRASTVLFPDAEtmaSNGQkYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVpLLGFLSPG 103
Cdd:TIGR01329 11 KNDPYDASSMPIYQTATFKQPLAI---ENGP-YDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDV-ITRLLNNG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 104 DHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVM 183
Cdd:TIGR01329 86 DEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 184 MDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTN-EKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIR 262
Cdd:TIGR01329 166 VDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKgEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 263 LEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVlaKGGHAQASAFLNALEIFGLGYSWGGY 342
Cdd:TIGR01329 246 IEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE--TGSVALSKRLVEATKLFSITVSFGSV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 552147923 343 QSL-ALEVKLGDRTV-----SKNDYAGPVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:TIGR01329 324 NSLiSMPCFMSHASIpaevrEERGLPEDLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
28-387 |
1.03e-65 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 214.47 E-value: 1.03e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 28 HGFVNPPVVRASTVLFPDAetmaSNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHAL 107
Cdd:PRK08776 28 YGAVTPPIVLSSNFSFDGF----GNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNALLQPGDTLV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 108 LVDSIYYSTRHFANTILKR---MGVDVEYYDPEigaDIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMM 184
Cdd:PRK08776 104 VPHDAYGGSWRLFNALAKKghfALITADLTDPR---SLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 185 DNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFG-TISTNEKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIRL 263
Cdd:PRK08776 181 DNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGaVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 264 EHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAkGGHAQASAFLNALEIFGLGYSWGGYQ 343
Cdd:PRK08776 261 RVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELE-GGEAAVRAFVDGLRYFTLAESLGGVE 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 552147923 344 SL------ALEVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFA 387
Cdd:PRK08776 340 SLiahpasMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLA 389
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
12-388 |
4.71e-65 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 212.07 E-value: 4.71e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 12 GINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMA----SNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPS 87
Cdd:PRK06434 8 GFNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAymdsTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 88 GLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEiGADIAKLMRPNTKVVFTESPASNTFEIQD 167
Cdd:PRK06434 88 GMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTD-RLNSLDFDPSNYDLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 168 IPAIAEAAHKGNAIVmmDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKC-WPQLLETHGTMGLCAGP 246
Cdd:PRK06434 167 IKNVSSFCHENDVIV--DATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSiFNNLVERRKTLGSNPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 247 DDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVlhpaleSHPGHEIWKRDFSGSSGIFSFVLAKggHAQASAF 326
Cdd:PRK06434 245 IQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNV------YYPDTEIGKKVLRGFGGMLSFELRS--MEDVHKF 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 552147923 327 LNALEIFGLGYSWGGYQSL-ALEVKLGDRTVSKND-----YAGPVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK06434 317 IRNLEIPMVAASLGGVESLiTLPVETSHSSLSPEErerlgISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
28-388 |
5.46e-64 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 209.37 E-value: 5.46e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 28 HGFVNPPVVRASTVLFPDAetmaSNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHAL 107
Cdd:PRK08045 20 YGCVVPPIHLSSTYNFTGF----NEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 108 LVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNT 187
Cdd:PRK08045 96 APHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 188 WATPLYFRALDFGVDISIHAATKYPSGHSDILFGT-ISTNEKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIRLEHH 266
Cdd:PRK08045 176 FLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVvIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 267 RKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSL- 345
Cdd:PRK08045 256 QRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFEL-DGDEQTLRRFLGGLSLFTLAESLGGVESLi 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 552147923 346 --ALEVKLGDRTVSKNDYAG---PVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK08045 335 shAATMTHAGMAPEARAAAGiseTLLRISTGIEDGEDLIADLENGFRA 382
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
27-387 |
2.94e-63 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 207.44 E-value: 2.94e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 27 YHGFVnPPVVRASTVLFPDAETMAsngqKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHA 106
Cdd:PRK08861 21 YHAVV-PPIYLSTNYGFPAFGEVP----KYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPDDLI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 107 LLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDN 186
Cdd:PRK08861 96 VAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 187 TWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGT-MGLCAGPDDTYQILRGLRTMGIRLEH 265
Cdd:PRK08861 176 TFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNcIGATGTPFDSYMTLRGIRTLGARMRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 266 HRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAkGGHAQASAFLNALEIFGLGYSWGGYQSL 345
Cdd:PRK08861 256 HEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFA-GSFEQLKVFVKALALFSLAESLGGVESL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 552147923 346 ------ALEVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFA 387
Cdd:PRK08861 335 ichpasMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFA 382
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
26-389 |
1.99e-62 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 205.07 E-value: 1.99e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 26 DYHGFVNPPVVRASTVLFPDaetmasnGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDH 105
Cdd:PRK06460 14 EATGAITTPIYQTTAYHYPE-------GEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 106 ALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMD 185
Cdd:PRK06460 87 VLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 186 NTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIRLEH 265
Cdd:PRK06460 167 ATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 266 HRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSL 345
Cdd:PRK06460 247 INRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEV-NGGQESALKVMKSLKLIIPAQTLGGVNSV 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 552147923 346 -ALEVKLGDRTVSKND-----YAGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK06460 326 iSHPATMSHRTLSLEErkivgITDSLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
9-389 |
6.49e-61 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 201.22 E-value: 6.49e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 9 EKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAE----TMASNGQKYTYGTRGTPTSEALCKAIDALEGSAGTVC 84
Cdd:PRK06767 2 KKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQqgeaSFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 85 VPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFE 164
Cdd:PRK06767 82 FGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 165 IQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFG-TISTNEKCWPQLLETHGTMGLC 243
Cdd:PRK06767 162 LIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGvTICKTRALAEKIRPMRKDIGGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 244 AGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPAleshpgHEIWKRDFSGSSGIFSFVLaKGGHAQA 323
Cdd:PRK06767 242 MAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPE------GELASRQMKRGGGVISFSI-KGGKEET 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 324 SAFLNALEIFGLGYSWGGYQSL--------------ALEVKLGdrtVSKNdyagpVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK06767 315 QAFINDLHFITIAVSLGDTETLiqhpatmthaaipaELRQEMG---IYDN-----LIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
56-389 |
1.16e-57 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 193.05 E-value: 1.16e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 56 YTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYD 135
Cdd:PRK07504 57 FIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVD 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 136 peiGADIA---KLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYP 212
Cdd:PRK07504 137 ---GLDLDnweKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHI 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 213 SGHSDILFGTISTNEkcwpQLLETHGTM-----GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVL 287
Cdd:PRK07504 214 DGQGRCLGGVVLSDK----AWIEEHLQDyfrhtGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVI 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 288 HPALESHPGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSL------ALEVKLGDRTVSKNDY 361
Cdd:PRK07504 290 YPGRADHPQADIIAKQMTGGSTLVAFEL-KGGKEAAFRFLNALKIVRISNNLGDAKSLithpatTTHKNLSPEARAELGI 368
|
330 340
....*....|....*....|....*...
gi 552147923 362 AGPVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK07504 369 SEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
12-388 |
2.93e-57 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 193.03 E-value: 2.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 12 GINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMAS--NGQK--YTYGTRGTPTSEALCKAIDALEGSAGTVCVPS 87
Cdd:PRK08134 8 GFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAAlfNLERagHVYSRISNPTVAVLEERVAALEGGVGAIATAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 88 GLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQD 167
Cdd:PRK08134 88 GQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 168 IPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKC-W------PQLLET---- 236
Cdd:PRK08134 168 IPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFdWeasgkfPELTEPyagf 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 237 HGTM----------------------GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESH 294
Cdd:PRK08134 248 HGMVfaeestvaafllrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESH 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 295 PGHEIWKRDF-SGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSLAL------EVKLGDRTVSKNDYAGPVIR 367
Cdd:PRK08134 328 PDHALAKRLLpRGAGSVFSFDL-KGGRAAGRKFIESLKLFSHLANVGDARSLVIhpasttHFRMDAAALAAAGIGEGTIR 406
|
410 420
....*....|....*....|.
gi 552147923 368 LQIGLEDVPDLIADLERGFAA 388
Cdd:PRK08134 407 LSIGLEDADDLIDDLKRALKA 427
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
7-389 |
1.02e-55 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 188.73 E-value: 1.02e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 7 KTEKLGINTRLAHD-------GYCPGDYHGFVNPPVVRASTVLFPDAE--------------TMASNGQKYTYGTRGTPT 65
Cdd:PRK07049 5 HPSKTHIGNRELHPetqmlnyGYDPELSEGAVKPPVFLTSTFVFRSAEdgrdffdyvsgrkePPAGEGAGLVYSRFNHPN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 66 SEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYY-----DPEIGA 140
Cdd:PRK07049 85 SEIVEDRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFadglsEAAIGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 141 DIAKLM-RPNTKVVFTESPASNTFEIQDIPAI------AEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPS 213
Cdd:PRK07049 165 AAEAAAaKGRVSLILIETPANPTNSLVDVAAVrrvadaIEARQGHRPIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 214 GHSDILFGTISTNEKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERV-LHPALE 292
Cdd:PRK07049 245 GHSDLVAGAVLGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLhYLPFLD 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 293 SH-PGHEIWKRDFSGSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSLA--------LEVKLGDRT---VSKNd 360
Cdd:PRK07049 325 PDsAYGAVYKRQCTGAGSTFSFDI-KGGQAAAFRFLNALQIFKLAVSLGGTESLAshpasmthSGVPADVRErigVLES- 402
|
410 420
....*....|....*....|....*....
gi 552147923 361 yagpVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK07049 403 ----TIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
55-387 |
2.03e-55 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 187.25 E-value: 2.03e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 55 KYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYY 134
Cdd:PRK07810 61 RFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 135 DpeiGADIAK----LMRPnTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATK 210
Cdd:PRK07810 141 D---GEDLSQweeaLSVP-TQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTK 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 211 YPSGHSDILFGTI--STNEKCWP-QLLETHgtMGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVL 287
Cdd:PRK07810 217 HIDGQGRVLGGAIlgDREYIDGPvQKLMRH--TGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 288 HPALESHPGHEIWKRDFSGSSGIFSFVLAKG---GHAQASAFLNALEIFGLGYSWGGYQSLALEV------KLGDRTVSK 358
Cdd:PRK07810 295 YPFLPSHPQYDLAKRQMSGGGTVVTFELDAPedaAKKRAFEVLDKLRVIDISNNLGDAKSLITHPattthrAMGPEGRAA 374
|
330 340
....*....|....*....|....*....
gi 552147923 359 NDYAGPVIRLQIGLEDVPDLIADLERGFA 387
Cdd:PRK07810 375 IGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
13-389 |
2.28e-53 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 181.05 E-value: 2.28e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 13 INTRLAHDGYCPGDYHGFVNPPVVrastvlFPDAETMASNGQK--YTYGTRGTPTSEALCKAIDALE-GSAGTVCvPSGL 89
Cdd:PRK08247 5 IETKLAQIGNRSDERTGTVNPPVY------FSTAYRHEGIGEStgFDYSRTGNPTRGVLEQAIADLEgGDQGFAC-SSGM 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 90 AAITVPLLGFLSPgDHALLVDSIYYST-RHFANTiLKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDI 168
Cdd:PRK08247 78 AAIQLVMSLFRSG-DELIVSSDLYGGTyRLFEEH-WKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 169 PAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTI-STNEKCWPQLLETHGTMGLCAGPD 247
Cdd:PRK08247 156 AAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVvAKGQELCERLAYYQNAAGAVLSPF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 248 DTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPaleshpgheiwkrdfsGSSGIFSFVLAKggHAQASAFL 327
Cdd:PRK08247 236 DSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP----------------GRGGMLSFRLQD--EEWVNPFL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 552147923 328 NALEIFGLGYSWGGYQSLAL------------EVKLGdRTVSKNdyagpVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK08247 298 KSLKLITFAESLGGVESFITypatqthadipeEIRIA-NGVCNR-----LLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
31-386 |
2.48e-53 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 183.69 E-value: 2.48e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 31 VNPPVVRASTVLFPDAetmASNGqKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVpLLGFLSPGDHALLVD 110
Cdd:PLN02509 104 MSTPLYQTATFKQPSA---IENG-PYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNGEEIVAGD 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 111 SIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWAT 190
Cdd:PLN02509 179 DVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMS 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 191 PLYFRALDFGVDISIHAATKYPSGHSDILFGTISTN-EKCWPQLLETHGTMGLCAGPDDTYQILRGLRTMGIRLEHHRKS 269
Cdd:PLN02509 259 PVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKgEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQEN 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 270 ALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVlaKGGHAQASAFLNALEIFGLGYSWGGYQSL---- 345
Cdd:PLN02509 339 ARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFI--TGSVALSKHLVETTKYFSIAVSFGSVKSLismp 416
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 552147923 346 --------ALEVKLGdRTVSKNdyagpVIRLQIGLEDVPDLIADLERGF 386
Cdd:PLN02509 417 cfmshasiPAEVREA-RGLTED-----LVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
6-388 |
4.91e-53 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 181.64 E-value: 4.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 6 LKTEKLGIntrlaHDGYCPGDYHGFVNPPVVRASTVLFPDAETMAS------NGQKYTYGTrgTPTSEALCKAIDALEGS 79
Cdd:PRK06084 1 MKLETLAI-----HAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADlfdlkvPGNIYTRIM--NPTNDVLEQRVAALEGG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 80 AGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPA 159
Cdd:PRK06084 74 VGALAVASGMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 160 SNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKC-WPQ------ 232
Cdd:PRK06084 154 NPAGNIIDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFpWAEhkerfa 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 233 LLET-----HG----------------------TMGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVER 285
Cdd:PRK06084 234 LLNTpdpsyHGvtyteafgpaafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAW 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 286 VLHPALESHPGHEIWKRDFSGS-SGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSLA------LEVKLGDRTVSK 358
Cdd:PRK06084 314 VKYAGLPDHPEHELARRYMGGKpASILSFGI-KGGQAAGARFIDALKLVVRLVNIGDAKSLAchpastTHRQLNDEELEK 392
|
410 420 430
....*....|....*....|....*....|
gi 552147923 359 NDYAGPVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK06084 393 AGVSRDMVRLSIGIEHIDDIIADLAQALDA 422
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
12-389 |
1.99e-51 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 177.60 E-value: 1.99e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 12 GINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYG---TR-GTPTSEALCKAIDALEGSAGTVCVPS 87
Cdd:PRK05994 7 GFATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGniyTRiTNPTNAVLEERVAALEGGTAALAVAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 88 GLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQD 167
Cdd:PRK05994 87 GHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 168 IPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTI--------STNEKcWPQLL----- 234
Cdd:PRK05994 167 IAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIvdggtfdwSKSGK-YPMLSeprpe 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 235 -------ETHGTMGLCAG--------------PDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALES 293
Cdd:PRK05994 246 yhglvlhETFGNFAFAIAarvlglrdlgpaisPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 294 HPGHEIWKRdFS--GSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSLAL------EVKLGDRTVSKNDyAGP- 364
Cdd:PRK05994 326 DPYHALAQK-YSpkGAGAVFTFGL-KGGYEAGVKLVSSLKLFSHLANIGDTRSLVIhpasttHRQLTDEQKVAAG-AGPd 402
|
410 420
....*....|....*....|....*
gi 552147923 365 VIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK05994 403 VVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
58-388 |
8.45e-50 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 173.40 E-value: 8.45e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 58 YGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYY-DP 136
Cdd:PRK07812 63 YTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDP 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 137 EIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHS 216
Cdd:PRK07812 143 DDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHG 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 217 DILFGTI----------------STNE------KCWP------------QLLEthgTMGLCAGPDDTYQILRGLRTMGIR 262
Cdd:PRK07812 223 TAIAGVIvdggtfdwtqgrfpgfTTPDpsyhgvVFAElgppayalkarvQLLR---DLGSAISPFNAFLIAQGLETLSLR 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 263 LEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDF-SGSSGIFSFVLAkGGHAQASAFLNALEIFGLGYSWGG 341
Cdd:PRK07812 300 IERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLApKGTGAVLSFELA-GGVEAGKAFVNALTLHSHVANIGD 378
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 552147923 342 YQSLAL------EVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK07812 379 VRSLVIhpasttHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADLEAGFAA 431
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
9-389 |
4.65e-48 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 168.90 E-value: 4.65e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 9 EKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASN------GQKYTYGTrgTPTSEALCKAIDALEGSAGT 82
Cdd:PRK05613 10 DQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRfaledlGPIYSRLT--NPTVEALENRIASLEGGVHA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 83 VCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYY-DPEIGADIAKLMRPNTKVVFTESPASN 161
Cdd:PRK05613 88 VAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 162 TFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTI-----------STNEKCW 230
Cdd:PRK05613 168 QADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwtveRDGKPVF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 231 PQLLET----HG---------------------TMGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVER 285
Cdd:PRK05613 248 PYFVTPdpayHGlkyadlgapafglkaragllrDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAK 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 286 VLHPALESHPGHEIWKR---DFSGSsgIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSLAleVKLGDRTVSKNDYA 362
Cdd:PRK05613 328 VNFAGLKDSPWYATKEKlglKYTGS--VLSFDI-KGGKDEAWAFIDALKLHSNLANIGDVRSLV--VHPATTTHSQSDEA 402
|
410 420 430
....*....|....*....|....*....|....*
gi 552147923 363 G--------PVIRLQIGLEDVPDLIADLERGFAAI 389
Cdd:PRK05613 403 GlaragitqATVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
34-388 |
1.46e-47 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 167.33 E-value: 1.46e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 34 PVVRASTVLFPDAETMAS----NGQKYTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLV 109
Cdd:PRK08248 30 PIYQTTSYGFRDSEHAANlfslKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQAAITYSILNIASAGDEIVSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 110 DSIYYSTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWA 189
Cdd:PRK08248 110 SSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEAVAAIAHEHGIPLIVDNTFA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 190 TPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKC-------WPQLLET----HGT------------------- 239
Cdd:PRK08248 190 SPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFdwkgsgkFPGLTEPdpsyHGLvytdavgeaayitkarvql 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 240 ---MGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDF-SGSSGIFSFVL 315
Cdd:PRK08248 270 lrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYLpKGQGAILTFGI 349
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 552147923 316 aKGGHAQASAFLNALEIFGLGYSWGGYQSLAL------EVKLGDRTVSKNDYAGPVIRLQIGLEDVPDLIADLERGFAA 388
Cdd:PRK08248 350 -KGGVEAGKKLIDSVKLFSHLANVGDSKSLIIhpasttHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQAIRQ 427
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
8-383 |
1.16e-44 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 159.83 E-value: 1.16e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 8 TEKLGINTRLAHDGYCPGDYHGFVnPPVVRASTVLFPDAETMAS----NGQKYTYGTRGTPTSEALCKAIDALEGSAGTV 83
Cdd:PRK06702 2 GESWGKGTICVQGGYTPKNGEPRV-LPLYQSTTYKYDTSDDLAAlfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 84 CVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIGAD-IAKLMRPNTKVVFTESPASNT 162
Cdd:PRK06702 81 ATASGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADeIVALANDKTKLVYAESLGNPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 163 FEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTIS-------TNEKcWPQLLE 235
Cdd:PRK06702 161 MNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwTNGK-YPELVE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 236 T----HGT----------------------MGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHP 289
Cdd:PRK06702 240 PdpsyHGVsyvqnfgaaayivkarvqllrdYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 290 ALESHPGHEIWKRDFS-GSSGIFSFVLaKGGHAQASAFLNALEIFGLGYSWGGYQSLALE-VKLGDRTVSKND-----YA 362
Cdd:PRK06702 320 GLDSNENYSLAQKYLKkGASGVLTFGI-KGGLEAAKEFIANVKLATLVTHVADARTCVIHpASTTHRQLSAEDqrlagVT 398
|
410 420
....*....|....*....|.
gi 552147923 363 GPVIRLQIGLEDVPDLIADLE 383
Cdd:PRK06702 399 SDLIRLSVGIEDVSDIIADLE 419
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
8-383 |
1.25e-44 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 158.06 E-value: 1.25e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 8 TEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPdaETMASNGQKYTYgTRgTPTSEALCKAIDALEGSAGTVCVPS 87
Cdd:PRK07269 2 SKDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHP--EFGQSTGFDYTR-TK-NPTRAKLEETLAAIESADYALATSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 88 GLAAITVPLLGFlSPGDHALLVDSIYYSTRHFANTILKRMGVDVEYYDPEigADIAKLMRPNTKVVFTESPaSNTFEIQ- 166
Cdd:PRK07269 78 GMSAIVLAFSVF-PVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTE--EELIAAIEEDTDIVYIETP-TNPLMVEf 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 167 DIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTN-EKCWPQLLETHGTMGLCAG 245
Cdd:PRK07269 154 DIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNdLELYEKLFYNLNTTGAVLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 246 PDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPaleshpgheiwkrdfsGSSGIFSFVLAKggHAQASA 325
Cdd:PRK07269 234 PFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYT----------------GKGGMISFKVAD--ETRIPH 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 552147923 326 FLNALEIFGLGYSWGGYQSL----ALEVKLGDRTVSKNDYA--GPVIRLQIGLEDVPDLIADLE 383
Cdd:PRK07269 296 ILNSLKVFTFAESLGGVESLitypTTQTHADIPAEVRHSYGltDDLLRLSIGIEDARDLIADLK 359
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
28-345 |
8.73e-34 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 129.89 E-value: 8.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 28 HGFVNPPVVRASTVLFPDAETM--ASNGQK------YTYGTRGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGF 99
Cdd:PLN02242 32 HGGVNMSIEASATFTVMEPDTMrrMFSGELgpdrdfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 100 LSPGDHALLVDSIYYSTRHFANTILKRM-GVDVEYYDPEIGADIAKLMRPN-TKVVFTESPASNTFEIQDIPAIAEAAHK 177
Cdd:PLN02242 112 CSSGGHVVASNTLYGGTHALLAHFLPRKcNITTTFVDITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 178 GNAIVMMDNTWAtPLYFRALDFGVDISIHAATKYPSGHSDILFGTIstnekCWPQLLeTHGTMGLCAG----------PD 247
Cdd:PLN02242 192 KGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAGAV-----CGPAEL-VNSMMDLHHGalmllgptmnPK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 248 DTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMveRVLHPALESHPGHEIWKR---DFSGSSGIFSFVLakGGHAQAS 324
Cdd:PLN02242 265 VAFELSERLPHLSLRMKEHCRRAMEYAKRMKELGL--KVIYPGLEDHPQHALLKSmanKGYGFGGLLCLDM--DTEERAN 340
|
330 340
....*....|....*....|....*
gi 552147923 325 AFLNALE---IFGL-GYSWGGYQSL 345
Cdd:PLN02242 341 RLMRYLQnstQFGFmAVSLGYYETL 365
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
82-210 |
3.75e-07 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 51.52 E-value: 3.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 82 TVCVP-SGLAAITVPLLGFLSPGDHALLVDSIYYSTRhFANtILKRMGVDVEYYDPEIG-----ADIA-KLMRPNTKVVF 154
Cdd:cd06451 52 TFLLSgSGTGAMEAALSNLLEPGDKVLVGVNGVFGDR-WAD-MAERYGADVDVVEKPWGeavspEEIAeALEQHDIKAVT 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 552147923 155 TESPASNTFEIQDIPAIAEAAHKGNAIVMMD---NTWATPLYFRAldFGVDISIHAATK 210
Cdd:cd06451 130 LTHNETSTGVLNPLEGIGALAKKHDALLIVDavsSLGGEPFRMDE--WGVDVAYTGSQK 186
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
88-203 |
2.23e-06 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 49.17 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 88 GLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDVEY--------YDPEigaDIAKLMRPNTKVVFTeSPA 159
Cdd:pfam00266 73 AINLVALSLGRSLKPGDEIVITEMEHHANLVPWQELAKRTGARVRVlpldedglLDLD---ELEKLITPKTKLVAI-THV 148
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 552147923 160 SNTF-EIQDIPAIAEAAHKGNAIVMMDNTWAT---PLYFRALdfGVDI 203
Cdd:pfam00266 149 SNVTgTIQPVPEIGKLAHQYGALVLVDAAQAIghrPIDVQKL--GVDF 194
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
81-211 |
3.67e-05 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 43.91 E-value: 3.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 81 GTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYSTRHFANTILKRMGVDV-----EYYDPEIGADIAKLMRPNTKVVFT 155
Cdd:cd01494 19 KAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAGAKPVPVpvddaGYGGLDVAILEELKAKPNVALIVI 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552147923 156 ESPASNTFEIQDIPAIAEAAHKGNAIVMMDNTWAT-----PLYFRaLDFGVDISIHAATKY 211
Cdd:cd01494 99 TPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGgaspaPGVLI-PEGGADVVTFSLHKN 158
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
25-185 |
1.40e-04 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 43.45 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 25 GDYHGFVNPPVVRAstvlFPDAETMASNGQkytYGTrgTPTSEALCKAIDAL--------EGSAGTVCVPSG-LAAITVP 95
Cdd:pfam00155 9 NEYLGDTLPAVAKA----EKDALAGGTRNL---YGP--TDGHPELREALAKFlgrspvlkLDREAAVVFGSGaGANIEAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 96 LLGFLSPGDhALLVDSIYYStrhFANTILKRMGVDV---EYYDPE-IGADIAKLMR---PNTKVVFTESPASNT---FEI 165
Cdd:pfam00155 80 IFLLANPGD-AILVPAPTYA---SYIRIARLAGGEVvryPLYDSNdFHLDFDALEAalkEKPKVVLHTSPHNPTgtvATL 155
|
170 180
....*....|....*....|
gi 552147923 166 QDIPAIAEAAHKGNAIVMMD 185
Cdd:pfam00155 156 EELEKLLDLAKEHNILLLVD 175
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
97-185 |
1.88e-04 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 43.20 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 97 LGFLSPGDHALLvdsiyysTR--HFANtIL------KRMGVDVEY-YDPEIG----ADIAKLMRPNTKVV-FTEspASNT 162
Cdd:COG0520 97 LGRLKPGDEILI-------TEmeHHSN-IVpwqelaERTGAEVRViPLDEDGeldlEALEALLTPRTKLVaVTH--VSNV 166
|
90 100
....*....|....*....|....
gi 552147923 163 F-EIQDIPAIAEAAHKGNAIVMMD 185
Cdd:COG0520 167 TgTVNPVKEIAALAHAHGALVLVD 190
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
102-185 |
2.97e-03 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 39.37 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 102 PGDHALLvdSIYystRHFANTI-----LKRMGVDVEY--------YDPEigaDIAKLMRPNTK-VVFTEspASNTF-EIQ 166
Cdd:cd06453 87 PGDEIVT--SVM---EHHSNIVpwqqlAERTGAKLKVvpvdddgqLDLE---ALEKLLTERTKlVAVTH--VSNVLgTIN 156
|
90
....*....|....*....
gi 552147923 167 DIPAIAEAAHKGNAIVMMD 185
Cdd:cd06453 157 PVKEIGEIAHEAGVPVLVD 175
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
106-184 |
5.78e-03 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 38.58 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552147923 106 ALLVDSIYYSTRHFANTILKRMGVDVEYYDPEIG-ADIAKL---MRPNTKVVFTESPasNTF-EIQDIPAIAEAAHKGNA 180
Cdd:PRK00451 157 VLVSGAVHPEYREVLKTYLKGQGIEVVEVPYEDGvTDLEALeaaVDDDTAAVVVQYP--NFFgVIEDLEEIAEIAHAGGA 234
|
....
gi 552147923 181 IVMM 184
Cdd:PRK00451 235 LFIV 238
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