|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-418 |
5.05e-94 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 288.02 E-value: 5.05e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIVIVFLLTALMLVLILMRDHPADVGLKSFGRLAPlpepeprksfgamlASPLVTLREASSTPTFWVLFLTFFVCGFST 257
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP--------------ASPGSTLKEALRSASFWLLALAFFLCGFAV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 258 NGLIQTHWISLCgDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALF 337
Cdd:cd17355 227 VGLIVHLVPYLA-DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 338 AIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAMVFM 417
Cdd:cd17355 306 AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
.
gi 552152457 418 I 418
Cdd:cd17355 386 I 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-426 |
3.78e-38 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 142.33 E-value: 3.78e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 17 YGWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMIS 96
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 97 AGLIGSIFMTEEWQMVaLWGVVIGLGTGMTTLVlGATVAARWFEK-RRGLVVGLMTASNATGQLVFMPILASVSQTIGWR 175
Cdd:COG2223 82 IGLLLLALAVSYWLLL-LLGLLLGIGGGGSFAV-GIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 176 TSLAIVIVFLLTALMLVLILMRDHPADVGLKSfgrlaplpepeprksfgamlASPLVTLREASSTPTFWVLFLTFFVCGF 255
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAA--------------------KASLRDQLEALRDPRFWLLSLLYFGTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 256 STNGLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELA 335
Cdd:COG2223 220 SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 336 LFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAMV 415
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
410
....*....|.
gi 552152457 416 FMISRPASRPA 426
Cdd:COG2223 380 LLLYRRPRRAA 390
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-426 |
4.32e-35 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 133.85 E-value: 4.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWgVVIGLGTGMTTlVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:COG2807 96 GLLLRSLAPSVALLLAGT-ALIGAGIAVGN-VLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIVIVFLLTALMLVLILMRDHPAdvglksfgrlaplpepeprksfGAMLASPLVTLREASSTPTFWVLFLTFFVCGFST 257
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPA----------------------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 258 NGLIqTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLsLIYLTFTDFSVYELALF 337
Cdd:COG2807 232 YAVV-AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL-AGLLGLLLAPGSLPWLW 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 338 AIFYGLDWVATVPPTVKLAAERFG-PEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAMVF 416
Cdd:COG2807 310 AVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
410
....*....|
gi 552152457 417 MISRPASRPA 426
Cdd:COG2807 390 LAGRPYVEDA 399
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
19-418 |
9.64e-30 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 118.87 E-value: 9.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:cd17353 2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGSIFMTEEWQMVALWGVVIGLGTGMTTLVLGATvAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSL 178
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVST-AVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 179 AIVIVFLLTALMLVLILMRDHPADVGLKSFGRLAPLPEPEPRKsfgamlasplVTLREASSTPTFWVLFLTFFVCGFSTN 258
Cdd:cd17353 161 LILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRD----------YTPREMLRTPTFWLLWLMFFLNATAGL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 259 GLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFA 338
Cdd:cd17353 231 MLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 339 IFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYdSYTPALILAGSLCFAAAAMVFMI 418
Cdd:cd17353 311 ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG-GYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-419 |
1.86e-27 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 112.26 E-value: 1.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVlGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSP-AIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIV--IVFLLTALMLVLILMRDhpadvglksfgrlaplpepeprksfgamlasplvtlreasstPTFWVLFLTFFVCGF 255
Cdd:cd17352 160 LLILggLCLNLCVCGLLLRLLKD------------------------------------------PTFVLLALGVSFAML 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 256 STNGLIqTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFT-DFSVYEL 334
Cdd:cd17352 198 GFFVPF-VYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPlATTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 335 ALFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAM 414
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
....*
gi 552152457 415 VFMIS 419
Cdd:cd17352 357 LFLLP 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-424 |
2.88e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 106.11 E-value: 2.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 11 AQRNIHYGWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAA 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 91 ALIMISAGLIGSIFMTEEWQMVALWgVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQ 170
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 171 TIGWRTSLAIVIVFLLTALMLvlilmrdhpadvglksfgrlaplpepeprksfgamlasplvtlreasstpTFWVLFLTF 250
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALL--------------------------------------------------RFWLLALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 251 FVCGFSTNGlIQTHWISLCGD-FGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNR--WLLFWFYALRGLSLIYLTFT 327
Cdd:COG2271 190 FLVYFALYG-FLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 328 DfSVYELALFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVrTDYDSYTPALILAGSL 407
Cdd:COG2271 269 P-SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-LDATGYQAAFLLLAAL 346
|
410
....*....|....*..
gi 552152457 408 CFAAAAMVFMISRPASR 424
Cdd:COG2271 347 ALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-378 |
7.42e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.89 E-value: 7.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGSIFMTEEWQMVALWgVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSL 178
Cdd:COG2814 89 SLLCALAPSLWLLLAAR-FLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 179 AIVIVFLLTALMLVLILmrdhpadvglksfgrlapLPEPEPRKSfgamlASPLVTLREASSTPTFWVLFLTFFVCGFSTN 258
Cdd:COG2814 168 LVNAVLALLALLLLLRL------------------LPESRPAAR-----ARLRGSLRELLRRPRLLLLLLLAFLLGFGFF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 259 GLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDfSVYELALFA 338
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLAL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 552152457 339 IFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQV 378
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-415 |
2.51e-20 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 92.09 E-value: 2.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVLgATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSA-VLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIVIVFLLTALMLVLILMRDHPADvglksfgrlAPLPEPEPRKSFGAMLASplvtlreaSSTPTFWVLF---LTFFVCG 254
Cdd:cd17314 160 YTILGILAAIVLSVVSLLGFKEPPD---------NQARLHVQKKKTQTMGEI--------FRDKVFWILFiaiFLVLIGG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 255 FSTNGLIQTHWISLCGDfgiAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFW-FYALRGLSLIYLTFTDFSV-Y 332
Cdd:cd17314 223 FLFIANMASLVRSLQLD---APSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSiLLTILGLGLCAFLFLLKMTpV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 333 ELALFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAA 412
Cdd:cd17314 300 GLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLAS 379
|
...
gi 552152457 413 AMV 415
Cdd:cd17314 380 AIL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-378 |
4.64e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.08 E-value: 4.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 24 ITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSI 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 104 FMTEEWQMVALWgVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIVIV 183
Cdd:pfam07690 81 FASSLWLLLVLR-VLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 184 FLLTALMLVLIlmrdhpadvglksfgrLAPLPEPEPRKSFGAMLASPLVTLREASSTPTFWVLFLtfFVCGFSTNGLIQT 263
Cdd:pfam07690 160 LSLLAAVLLLL----------------PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLA--LLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 264 HWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFA--IFY 341
Cdd:pfam07690 222 YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLalLLL 301
|
330 340 350
....*....|....*....|....*....|....*..
gi 552152457 342 GLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQV 378
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
18-343 |
5.30e-16 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 79.02 E-value: 5.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMtTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCF-TFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIVivfllTALMLVLILmrdhpadvglksfgrlaplpepeprksFGAMLAsplvTLREASStpTFWVLFLTFFVCGFST 257
Cdd:cd17422 160 LLVV-----GALQLNIVV---------------------------CGALLR----VLKEPGF--ICYALFGLFATLGFFA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 258 NGLiqtHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDR--FDNRWLLFWFYALRGLSLIYLTFTdFSVYELA 335
Cdd:cd17422 202 PQL---YIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKcpIRKIYIELICVILLCVVLLLFPFA-YGFWSLL 277
|
....*...
gi 552152457 336 LFAIFYGL 343
Cdd:cd17422 278 VCSIFYGF 285
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
18-350 |
3.06e-15 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 76.66 E-value: 3.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVLGATVAaRWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVS-RYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIVIVFLLT-----ALMLVLILMRDhpadvglksfgrlAPLPEPEPRKSFGAMLASPLVTLReasstptfWVLFLTFFV 252
Cdd:cd17423 160 LLLLSALSLHlvpcgALLRPLALPGD-------------PPAPPRSLSAAFGLSLLTHRAFLR--------YALATTLIN 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 253 CGFSTNGLiqtHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNR--WLLFWFYALRGLSLIYLTFTDfS 330
Cdd:cd17423 219 TGYFIPYV---HLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRllHLLVLWTALTGLSLLLLPLAK-V 294
|
330 340
....*....|....*....|
gi 552152457 331 VYELALFAIFYGLDWVATVP 350
Cdd:cd17423 295 YGSLLALAVAYGFCAGALAP 314
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-416 |
1.44e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 71.69 E-value: 1.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 26 FLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFM 105
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 106 TEeWQMVALWGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIVIVFL 185
Cdd:cd06174 82 PS-FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 186 LTALMLVLILMRDHPadvglksfgrlapLPEPEPRKSFGAMLASPLVTLREASSTPTFWVLFLTFFVCGFSTNGLIQTHW 265
Cdd:cd06174 161 LALLAAILLLLVVPD-------------PPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 266 ISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFAIFYGLDW 345
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552152457 346 VATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAMVF 416
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-370 |
7.63e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.53 E-value: 7.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 48 REFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFmTEEWQMVALWGVVIGLGTGMTT 127
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF-ATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 128 LVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIVIVFLLTALMLVLILMRDhpadvglks 207
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE--------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 208 fgrlaplpEPEPRKSFGAMLASPLVTLREASSTPTFWVLFLTFFVCGFSTNGLIQTHWISLCGDFGIAPVGAAGILAVIG 287
Cdd:cd17325 174 --------PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 288 AFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDfSVYELALFAIFYGLDWVATVPPTVKLAAERFGPEKAGL 367
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
|
...
gi 552152457 368 IFG 370
Cdd:cd17325 325 AMG 327
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-351 |
1.31e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.65 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLATAAAMGsagiLIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:cd17324 2 LALALAAFAIGTTEYVIQG----LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGSIFMTEEWQMVaLWGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSL 178
Cdd:cd17324 78 NLLAALAPSFALLL-LARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 179 AIVIVFLLTALMLVLILMRDHPAdvglksfgrlAPLPEPEPRKSFGAMLASPLVtlreasstptfWVLFLTFFVCGFSTN 258
Cdd:cd17324 157 LAIAVLALLAALLLWRLLPSLPP----------KKPGSLGLLSSLLLLLRNPRL-----------RLAYLITFLLFGGFF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 259 GLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRwLLFWFYALRGLSLIYLTFTDFSVYELALFA 338
Cdd:cd17324 216 ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR-ALLIALLLLAAALLLLTLLGPSPLLLLVGL 294
|
330
....*....|...
gi 552152457 339 IFYGLDWVATVPP 351
Cdd:cd17324 295 VLWGLGFFAAHSA 307
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-340 |
1.68e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.26 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGsIFMTEEWQMVALWGVVIGLGTGMtTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFmPILASVsqTIGWRTSL 178
Cdd:COG0738 87 LLL-FALAPSYPLLLLALFLLGLGLGL-LDVAANPYVAALGPETAASRLNLLHAFFSLGALLG-PLLGGL--LILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 179 AIVIVFLLTALMLVLILMrdhpadvglksFGRLAPLPEPEPRKSFGamlASPLVTLREASSTPTFWVLFLTFFVCGFSTN 258
Cdd:COG0738 162 SWHLPYLILAVLLLLLAL-----------LFLRSKLPEIEEEEEEA---AGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 259 GLIQthWIS--LCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELAL 336
Cdd:COG0738 228 AIGD--WLPlyLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIG 305
|
....
gi 552152457 337 FAIF 340
Cdd:COG0738 306 LALV 309
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
19-416 |
3.99e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.13 E-value: 3.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGSIFMTEEWQMVALWGVViGLGTGmTTLVLGATVAARWF-EKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTs 177
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLL-GVAEA-GFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 lAIVIVFLLTALMLVLILMRdhpadvglksfgrlaplpepeprksfgamlasplvtlreassTPTFWVLFLTFFVCGFST 257
Cdd:cd17319 159 -AFIIEGLLGLLLAVLWWFY------------------------------------------LRQVWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 258 NGLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDN---RWLLFWFYALRGLSLIYLTFTDfSVYEL 334
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTT-SPVVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 335 ALFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAM 414
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
..
gi 552152457 415 VF 416
Cdd:cd17319 355 VL 356
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
16-343 |
1.64e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 1.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 16 HYGWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMI 95
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 96 SAGLIGSIFMTEEWQMVALwGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWR 175
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLIL-RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 176 TSLAIVIVFllTALMLVLILM------------------RDHPADVGLKSFGRLAPLPEPEPRKSFGAMLASPLVTLREA 237
Cdd:TIGR00895 172 SLFYVGGIA--PLLLLLLLMRflpesidflvskrpetvrRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 238 SSTPTFWVL-FLTFFVCGFSTNgliqthWI-SLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFdNRWLLFWFYA 315
Cdd:TIGR00895 250 RITVLLWLLyFMLLVGVYFLTN------WLpKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL-GPRVTALLLL 322
|
330 340
....*....|....*....|....*...
gi 552152457 316 LRGLSLIYLTFTDFSVYELALFAIFYGL 343
Cdd:TIGR00895 323 LGAVFAVLVGSTLFSPTLLLLLGAIAGF 350
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
17-180 |
5.42e-10 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 60.91 E-value: 5.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 17 YGWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMIS 96
Cdd:TIGR00892 16 WGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 97 AGLIGSIFMTEEWQMVALWGVVIGLGTGMtTLVLGATVAARWFEKRRGLVVGLMTAsnatGQLVFMPILASVSQ----TI 172
Cdd:TIGR00892 96 LGMILASFSSNVIELYLTAGFITGLGLAF-NFQPSLTMLGKYFYRRRPLANGLAMA----GSPVFLSTLAPLNQylfeSF 170
|
....*...
gi 552152457 173 GWRTSLAI 180
Cdd:TIGR00892 171 GWRGSFLI 178
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-307 |
2.17e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 58.93 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 46 LQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVALWgVVIGLGTGM 125
Cdd:TIGR00881 21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALW-ALNGIFQGM 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 126 TTLVLGATVAARWFEKRRGLVVGLM-TASNATGQLVFMPILASVSQTIGWRTSLAIVIVFLLTALMLVLILMRDHPADVG 204
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 205 LksfGRLAPLPEPEPRKSF---GAMLASPLVTLREASSTPTFWVLFLTFFVCGFSTNGLIQTHWISLCGDFGIAPV--GA 279
Cdd:TIGR00881 180 L---PPAEEMPNEEPDGDAekkEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEkaSW 256
|
250 260
....*....|....*....|....*...
gi 552152457 280 AGILAVIGAFdlIGTIMSGWLSDRFDNR 307
Cdd:TIGR00881 257 AFTLYELGGL--VGTLLAGWLSDKLFNG 282
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
34-316 |
3.35e-09 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 58.36 E-value: 3.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 34 AAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVA 113
Cdd:cd17339 13 PAITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 114 lwGVVIGLGTGMTTLVLGATVaARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQT--IGWRTSLAIVIVFLLTALML 191
Cdd:cd17339 93 --TALAGAGIAVGNVLLPSLI-KRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQAlgGGWRGALAIWALPALLALLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 192 VLILMRDHPAdvglksfgrlapLPEPEPRKSFGAMLASPLVtlreasstptfWvlFLTFFVCGFSTNGLIQTHWI-SLCG 270
Cdd:cd17339 170 WLPQLRRRKR------------AAAAAAPLTKISVWRSPLA-----------W--QVTLFMGLQSLLFYTLMAWLpTILI 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 552152457 271 DFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYAL 316
Cdd:cd17339 225 DAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAV 270
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-180 |
5.76e-09 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 57.53 E-value: 5.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVLGATVaARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMV-GQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNA 159
|
...
gi 552152457 178 LAI 180
Cdd:cd17429 160 MFI 162
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
27-416 |
1.38e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 27 LTMLATAAAMGSAGI--LIDPLQREFGWTNANISF---AMALRLVLFGLmgpFAAAFMNQFGLRRVVAAALIMISAGLIG 101
Cdd:cd17475 1 ATLAQAAASLVAQGIpaLAPFLQEDLHLSLAQVGLllsALNLGVAVSML---PAGWLLDRFGERRVLAVGLLLMGAAALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 102 SIFMTEEWqMVALWGVVIGLGTGmTTLVLGATVAARWFEKR-RGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAI 180
Cdd:cd17475 78 MALVGSYP-VLLVLLFLVGAGYG-SVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 181 VIVFLLTALMLVLILMRDHPAdvglksfGRLAPLPEPEPRKSFGAMLASPLVtlreasstptFWVLFLTFFVCGFSTngL 260
Cdd:cd17475 156 AGLVSILAAVLFWLFYREPPA-------ASAATESASTLLRSLKEVLRNRDV----------WLIAIAGALLVAPQF--A 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 261 IQTHWISLCGD-FGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDN---RWLLFWFYALRGLSLIYLTFTDFSV--YEL 334
Cdd:cd17475 217 LLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTplWLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 335 ALFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAgSLCFAAAAM 414
Cdd:cd17475 297 VLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLAL-ALLLVLAAL 375
|
..
gi 552152457 415 VF 416
Cdd:cd17475 376 LL 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
18-419 |
2.11e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGlmgPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFA---PLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALwGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQtIGWRTs 177
Cdd:cd17473 78 GGVAGLFLDSLYALLAS-RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRA- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 laiviVFLLTALMLVLILMRdhpadvglksfgrLAPLPEPEPRKSFGAmlASPLVTLREASSTPTFWVLFLTFFvcGFST 257
Cdd:cd17473 155 -----PFLVYLLALPVLILV-------------LLFLPEPARKSKSAA--SPGAATAAALPWKRVLPIYFLAFL--AMLL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 258 NGLIQTHWISLCGDFGIA-PVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDfSVYELAL 336
Cdd:cd17473 213 FYVIPIQLPFLLQERGGGsAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS-GLWVVLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 337 FAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAMVF 416
Cdd:cd17473 292 GAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
...
gi 552152457 417 MIS 419
Cdd:cd17473 372 LLR 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
26-363 |
5.94e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.02 E-value: 5.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 26 FLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFm 105
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 106 teeWQMVALWGV---VIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVfMPILASVSQTIGWrTSLAIVI 182
Cdd:cd17477 81 ---TDSPWVWFLlrfVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGA-LPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 183 VFLLTALMLVLILMRDHPadvglksfgrlaPLPEPEPRKSFGAMLASPLvtlreasstptfwvLFLTFFVCGFST---NG 259
Cdd:cd17477 156 VLLLLALVPLLLTRRAAP------------EIEEAESISLRRLLRIAPL--------------ALLGAFVAGFLEgafYS 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 260 LIQTHWISLcgdfGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFAI 339
Cdd:cd17477 210 LLPLYGLRL----GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF 285
|
330 340
....*....|....*....|....
gi 552152457 340 FYGLDWVATVPPTVKLAAERFGPE 363
Cdd:cd17477 286 LWGGAAGPLYTLALALAGDRLPGD 309
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
24-330 |
6.39e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.10 E-value: 6.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 24 ITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSI 103
Cdd:cd17341 3 LSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 104 FMTEEWQMVALWGVVIGLGTGmtTLVLGATVAARWFEKRR-----GLVVGLMTASNATGQLVFMPILASVSQ---TIGWR 175
Cdd:cd17341 83 LAVSSYWGLLVLGFLLGFAGA--NFASGQPWASFWFPKEKiggaaGGIAGAGNMGVAVSQLLAPLIAGAIVFdggFVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 176 TSLAIVIVFLLTALMLVLILMRDHPADvglksfgrlaplpepepRKSFGAMLASPLVTLREASStptfWVLFLTFFVC-- 253
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTG-----------------KASALEFLKVQLAVLKNYRT----WILSLLYGVTfg 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 254 ---GFS--TNGLIQTHwislcgdFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTD 328
Cdd:cd17341 220 sfvGFSnvLPTYFKTR-------FGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSL 292
|
..
gi 552152457 329 FS 330
Cdd:cd17341 293 PT 294
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
18-188 |
7.38e-07 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 50.97 E-value: 7.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMtTLVLGATVAARWFEKRRGLVVGLMTAsnatGQLVFMPILASVSQ----TIG 173
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAF-NLQPALTIIGKYFYKKRPIANGLAMA----GSPVFLSTLAPLNQflfnQFG 155
|
170
....*....|....*
gi 552152457 174 WRTSLAIVIVFLLTA 188
Cdd:cd17427 156 WRGSFLILGGLLLNC 170
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
18-186 |
7.45e-07 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 51.03 E-value: 7.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMtTLVLGATVAARWFEKRRGLVVGLMTAsnatGQLVFMPILASVSQ----TIG 173
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAF-NLNPALTMIGKYFYKKRPLANGLAMA----GSPVFLSTLAPLNQwffdIFG 155
|
170
....*....|...
gi 552152457 174 WRTSLAIVIVFLL 186
Cdd:cd17426 156 WRGSFLILGGLLL 168
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-195 |
7.64e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 7.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 26 FLTMLATAAAMGSAGILIDPL----QREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIG 101
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLplyaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 102 SIFMTEEWQMVALWgVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIV 181
Cdd:cd17325 282 LPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|....
gi 552152457 182 IVFLLTALMLVLIL 195
Cdd:cd17325 361 AALLLLAAVLFLLL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
29-366 |
7.79e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.67 E-value: 7.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 29 MLATAAAMGSAGILIDPLQ---REFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFM 105
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPlyaHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 106 TEEWQMVALwGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIVIVFL 185
Cdd:cd17489 82 TSVALLLVL-RLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 186 LTALMLVLILMRDHPADVglksfgrlaplPEPEPRKSFGAMLASPLVTLreasstPTFWVLFLTFFVCGFSTngliqthW 265
Cdd:cd17489 161 LLALLLVFLVKDPPPVAA-----------EEAEAGTRAFRRLVEKKVLP------PALILFLASIAYGAIST-------F 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 266 ISLCGDfGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDfSVYELALFAIFYGLDW 345
Cdd:cd17489 217 LPLYAA-ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG-SPWMLLLAAVLYGLGF 294
|
330 340
....*....|....*....|.
gi 552152457 346 VATVPPTVKLAAERFGPEKAG 366
Cdd:cd17489 295 GLLFPALQALAVDLVPPHRRG 315
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-373 |
1.53e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 46 LQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVALwGVVIGLGTGM 125
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL-VALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 126 TTlVLGATVAARWFEKRRGLVVGLMTASNATGQlVFMPILASVsqTIGWRTSLAIVIVFLLTALMLVLILmrdhpadvgl 205
Cdd:cd17478 101 FH-PEGARLASQAAGGRRGLAMSIFSVGGNLGF-ALGPLIAAA--LVALFGGLGLLILLIIPGLAVALLL---------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 206 ksFGRLAPLPEPEPRKSFGAMLASPLVTLREASSTPTFWVLFLTFFVCGFSTngLIQTHWISLcgdfGIAPVGAAGILAV 285
Cdd:cd17478 167 --LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTT--FLPFYLVQR----GYSLVFAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 286 IGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFAIFYGLdwVATVPPTVKLAAErFGPEKA 365
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLL--FASFPVTVVLAQE-LLPGNV 315
|
....*...
gi 552152457 366 GLIFGWVF 373
Cdd:cd17478 316 GLASGLMM 323
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
18-181 |
1.57e-06 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 49.81 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGmttLVLGATV--AARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWR 175
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCG---LVYAATVtiTCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLD 157
|
....*.
gi 552152457 176 TSLAIV 181
Cdd:cd17428 158 GCLLIV 163
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-303 |
2.22e-06 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 49.42 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVLGATVAaRWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTS 177
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVG-KYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 178 LAIVIVFLLTALMLvlilmrdhpadvglksfgrlaplpepeprksfGAMLASPLvtlreassTPTFWVLFLTFFVCGFST 257
Cdd:cd17424 160 LLILGGFVLNLCVC--------------------------------GALMRFLL--------MPDFLVLAVSVLFLAYGC 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 552152457 258 NGLIqTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDR 303
Cdd:cd17424 200 SPPF-VYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDR 244
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
18-188 |
6.72e-06 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 47.84 E-value: 6.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMtTLVLGATVAARWFEKRRGLVVGLMTASNATGqLVFMPILAS-VSQTIGWRT 176
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCF-SFQSSVTVLGFYFVRRRALANALASTGTSIG-LTLWPLLSQyLLEEMGWRG 158
|
170
....*....|..
gi 552152457 177 SLAIVIVFLLTA 188
Cdd:cd17425 159 SFLVFGGVLLNC 170
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
18-186 |
1.85e-05 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 46.65 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGM----TTLVLGatvaaRWFEKRRGLVVGLmtasNATGQLVFMPILASVSQTI- 172
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALnfqpSLIMLG-----RYFDKRRPLANGL----AAAGSPVFLSALSPLGQILl 151
|
170
....*....|....*..
gi 552152457 173 ---GWRTSLAIVIVFLL 186
Cdd:cd17430 152 eeyGWRGGFLILGGLLL 168
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
49-307 |
1.92e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 49 EFGWTNANISFAMALRLVLFGLMGpfaaafmNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVALWGVvIGLGTGMTTL 128
Cdd:cd17312 39 DLGIIGSAFLIAYAVGKFISGFLS-------DRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL-NGLFQSMGWP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 129 VLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIV-IVFLLTALmLVLILMRDHPADVGLKS 207
Cdd:cd17312 111 PCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPgIVGLVVAI-ILFFFLRDSPPYVWVLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 208 FGRLAplpepeprksfgamlasplvtLREASSTPTFWVLFLtffvcgfstngLIQTHWISLcgdfgIAPVGAAGILAVIG 287
Cdd:cd17312 190 LAYAF---------------------VYIVRYACLDWGPLY-----------LYEVKGYSL-----IDAGWFSSLYEVGG 232
|
250 260
....*....|....*....|
gi 552152457 288 afdLIGTIMSGWLSDRFDNR 307
Cdd:cd17312 233 ---IAGTILAGLLSDKLFGG 249
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
38-184 |
2.55e-05 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 46.34 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 38 SAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVaLWGV 117
Cdd:PRK09705 27 SVGPLLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLL-SSAL 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 552152457 118 VIGLGTGMTTLVLGAtVAARWFEKRRGLVVGLMTASNATGQ---LVFMPILASVS----QTIGWRTSLAIVIVF 184
Cdd:PRK09705 106 LGGVGIGIIQAVMPS-VIKRRFQQRTPLVMGLWSAALMGGGglgAAITPWLVQHSetwyQTLAWWALPAVVALF 178
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-343 |
3.22e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.65 E-value: 3.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 46 LQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVALwGVVIGLGTGM 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG-RALQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 126 TTLVLgATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIVIVFLLTALmlvlilmrdhpadvgl 205
Cdd:cd17504 101 FPLAF-ALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLA---------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 206 ksfgrlaplpepeprksfgamLASPLVTLREASStPTFWVLFLTFFVCGFSTNGLIQTHWISL----CGDFGIAPVGAAG 281
Cdd:cd17504 164 ---------------------ALVPLIDLRLLRR-RNVLLANITALLAGFGMFMVFQLLPQLLqlptPTGFGLGITEAGL 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552152457 282 ILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFAIFYGL 343
Cdd:cd17504 222 LLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGI 283
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-195 |
8.78e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 8.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 55 ANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWqMVALWGVVIGLGTGMTTLVLGATV 134
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPW-MLLLAAVLYGLGFGLLFPALQALA 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552152457 135 AARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRtslaivIVFLLTALMLVLIL 195
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYR------AMFLLAAVVVLLAL 360
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
39-343 |
8.90e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.50 E-value: 8.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 39 AGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMvALWGVV 118
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL-ALLRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 119 IGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRtslaivIVFLLTALMLVLILmrd 198
Cdd:cd17365 97 TGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWR------SVFLLGGVPPLILL--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 199 hpadvglksfgrlaplpepeprksfgamlasPLVTlreasSTPTFWVlflTFFVCGFSTNGLIQthWI-SLCGDFGIAPV 277
Cdd:cd17365 168 -------------------------------PLLR-----GTLLLWV---TFFMGLLLVYLLNS--WLpKLMVEAGYSLS 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 552152457 278 GAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDFSVYELALFAIFYGL 343
Cdd:cd17365 207 QALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGA 272
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
38-199 |
1.02e-04 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 44.18 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 38 SAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLI----GSIFmteewqmvA 113
Cdd:cd17409 17 GVAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYGLERSLFAALLLIAAGIAlrstGSVW--------A 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 114 LWG--VVIGLGTGMTTlVLGATVAARWFEKRRGLVVGL----MTASNATGQLVFMPiLASVSQTiGWRTSLAIVIVFLLT 187
Cdd:cd17409 89 LYLgtAIIGAGIAIGN-VLLPSLLKRDFPARVATLTGAyaltMGVGAALGSALVVP-LAQVLAF-GWQLALGAFLVFPLV 165
|
170
....*....|..
gi 552152457 188 ALMLVLILMRDH 199
Cdd:cd17409 166 AALIWLPQLRRH 177
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
19-363 |
2.58e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.94 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLAtaaaMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:cd17474 2 YAVFFATLLAVLG----VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGsIFMTEEWQMVALWGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFmPILASVSQTIGWRTSL 178
Cdd:cd17474 78 GLL-CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 179 AIVIVFLLTALMLVLILMRdhpadvglksfgrlaPLPEPEPRKSfgamlASPLVTLREASSTPTFWVLFLTFFVCGFSTN 258
Cdd:cd17474 156 FLLAALIPVAFLAILFLLP---------------EPKEKAKSSS-----ATKLRDLKKALRGRGLLTFLVSAFLYFFLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 259 GLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSG-WLSDRFDNRWLLFWFYALRGLSLIYLTFTDfSVYELALF 337
Cdd:cd17474 216 AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIA 294
|
330 340
....*....|....*....|....*.
gi 552152457 338 AIFYGLDWVATVPPTVKLAAERFGPE 363
Cdd:cd17474 295 IVLFGLGLGLNLPLLTTLVTELAPEE 320
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
132-327 |
2.89e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 42.71 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 132 ATVAARWFEKRR-GLVVGLMTAS-NATGQLVfmPILA-SVSQTIGWRTSLAIVIVFLLTALMLVLILMRDHPADVGLKSF 208
Cdd:cd17343 113 AKILRKWFSPSQfGTWWSVLSTSmNLAGSLG--PILAtLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNI 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 209 grlaplpEPEPRKSFGAMLASPLVTLREASSTPTFWVLFLTFF-VCGFSTNGLIQTHwISLCGDFGIAPVGAAGILAVIG 287
Cdd:cd17343 191 -------EEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLvVFGVKTAVTDWGQ-LFLIQDKGQSALTGSSFMSSLE 262
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 552152457 288 AFDLIGTIMSGWLSDRFDNRW-----------LLFWFYALRGLSLIYLTFT 327
Cdd:cd17343 263 VGGFVGSIAAGYLSDWAVAKHgsssrgnprmpLALVFMAGLTVSLHLFRVH 313
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
78-343 |
3.24e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 78 FMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVALwGVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATG 157
Cdd:cd17327 64 LLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIAL-RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 158 QlVFMPILASVSQTI-------GWRtsLAIVIVFLLTALMLVLIL--MRDHPADVGL--KSFGRLAPLPEPEPRKSFGAM 226
Cdd:cd17327 143 S-IFGGLLAYGVFKIlgvgglaGWR--WLFIIEGLITIIIGLVIFfwLPDNPSKAWFltEEEKELAVERLRANQTGKGDQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 227 LASpLVTLREASSTPTFWVLFLtFFVCGFSTNGLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDN 306
Cdd:cd17327 220 KFK-WKQIKEAFKDPRTWLLFL-FFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKK 297
|
250 260 270
....*....|....*....|....*....|....*....
gi 552152457 307 RWLLFWFYALRGL--SLIYLTFTDFSVYELALFAIFYGL 343
Cdd:cd17327 298 RGLFAIFACVLALvgSIILLAAPNPPGAYFAAYILGGGS 336
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
271-429 |
7.87e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 271 DFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTFTDfSVYELALFAIFYGLDWVATVP 350
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT-SYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 552152457 351 PTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTPALILAGSLCFAAAAMVFMISRPASRPALQA 429
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
40-326 |
9.87e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.13 E-value: 9.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 40 GILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIFMTEEWQMVALWGVVi 119
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALA- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 120 GLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLV----FMPILASVSQTIGWRtslAIVIVFLLTALMLVLIl 195
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLatllAALLFPLLPPEIAWR---VLFLLGALPALLVLFI- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 196 mRDHpadvglksfgrlapLPEPE----PRKSFGAMLASP-LVTLREASSTPTFWVLFLTFFVCGFSTNGLIQTHWISLCG 270
Cdd:cd17371 174 -RRF--------------VKEPPqwqaARAARRHFADRPsLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTG 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 552152457 271 DFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWlLFWFYALRGLSLIYLTF 326
Cdd:cd17371 239 ERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN-NFALFALGSAISILLYF 293
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-125 |
1.12e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 25 TFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLIGSIF 104
Cdd:cd17503 184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263
|
90 100
....*....|....*....|...
gi 552152457 105 MTEE--WQMVALWGVVIGLGTGM 125
Cdd:cd17503 264 LTPDtsLWLIILPLFIRGLGMGL 286
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-301 |
1.27e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 19 WVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAG 98
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 99 LIGSIFMTEEWQMVALWgVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSL 178
Cdd:COG0477 93 SLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 179 AIVIVFLLTALMLVLILMRDHPADVGLKSFGRLAPLPEPEPRKSFGAMLASPLVTLREASSTPTFWVLFLTFFVCGFSTN 258
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 552152457 259 GLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLS 301
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
25-196 |
1.83e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.38 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 25 TFLTMLATAAAMGSAGILIDPLQREFGWTNANIS---FAMALRLVLFGLmgpFAAAFMNQFGLRRVVAAALIMISAGLIG 101
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSvifSSQNAGYLIGSL---LAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 102 sIFMTEEWQMVALWGVVIGLGTGmTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFmPILASVSQTIGWRTSLAIV 181
Cdd:cd17333 78 -IFATPSIYLFVVLMFLAGLGAG-ILDTGANTFVGALFEESSATRLNVLHGFFGLGALIG-PLIATSLLTSELSWSWAYL 154
|
170
....*....|....*
gi 552152457 182 IVFLLTALMLVLILM 196
Cdd:cd17333 155 IIGLIYLLLAILILL 169
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-303 |
2.37e-03 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 39.81 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISA 97
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 98 GLIGSIFMTEEWQMVALWGVVIGLGTGMTTLVlGATVAARWFEKRrgLVVGLMTASNATG-QLVFMPILASVSQTIGWRT 176
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQA-AAVMTAKYFKKR--LATAYAIARSGMGlTFALAPFTQLLLDEYDWQG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 177 SLaivIVFLLTALMLVLILMRDHPADVGLksfgrlaplpepeprksfgamLASPLVTLReasstpTFWVLF--LTFFVCG 254
Cdd:cd17421 158 AL---LIFGGIMLNLVASGMLLRPIDFSL---------------------LKDPFFCIY------TWSFVFsqLAYFIPY 207
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 552152457 255 FstngliqtHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDR 303
Cdd:cd17421 208 F--------HLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQ 248
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
246-426 |
2.44e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 246 LFLTFFVCGFSTNGLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLT 325
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 326 FTDfSVYELALFAIFYGLDWVATVPPTVKLAAERFGPEKAGLIFGWVFTGHQVGAAAAAAFAGFVrTDYDSYTPALILAG 405
Cdd:pfam07690 81 FAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWRAAFLILA 158
|
170 180
....*....|....*....|.
gi 552152457 406 SLCFAAAAMVFMISRPASRPA 426
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKR 179
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
18-229 |
4.26e-03 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 39.05 E-value: 4.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWT-NANISFAMA----LRLVLFGLMGPFAAAFMNQFGLRRVVAAAL 92
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLgDPEASFKAAwvgaLAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 93 IMISAGLIGSIFMTEEWQMVALWGVVIGLGTGM----TTLVLGatvaaRWFEKRRGLVVGLMTASNATGQLVFMPILASV 168
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFayqpSLVILG-----HYFKRRLGLVNGFVTAGSSVFTVILPPLLRKL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 552152457 169 SQTIGWRTSLAIVIVFlltalMLVLILMRdhpadvglKSFGRLAPLPEPEPRKSFGAMLAS 229
Cdd:cd17420 156 LDSYGLEGTLRVLSLF-----MFVLILCS--------FTYRPLHPSPEDPKSKPGRRTLHS 203
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-418 |
6.28e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 6.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 25 TFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRV-VAAALIMISAGLIGSI 103
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVfLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 104 FMTEEWQMVALwgVVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVSQTIGWRTSLAIVIV 183
Cdd:cd17321 81 APSLAFLIAAR--ALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 184 FLLTALMLvlilmrdhpadvglksfgrlaplpepeprksfgamlasplvtlreassTPTFWVLFLTFFVCGFSTNGLIQT 263
Cdd:cd17321 159 IGLVALLL------------------------------------------------ARTFSGAVLAAFLLGAALGGLLFL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 264 HWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLSLIYLTF--TDFSVYELALFAIFY 341
Cdd:cd17321 191 LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgADSSVWLLLPGLVLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 342 GLDWVATVPPTVKLAAERFGPEKAG----------------------LIFGWVFTGHQVGAAAAAAFAGFVRTDYDSYTP 399
Cdd:cd17321 271 GLGLGLFATPLTNAALSSVPKEKAGaasgilntarqlggalgvallgALLTAGLSANLGDSGVAALLSAAAAAFAAGFHL 350
|
410
....*....|....*....
gi 552152457 400 ALILAGSLCFAAAAMVFMI 418
Cdd:cd17321 351 AFLVAAALALLAALLALLL 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-168 |
7.04e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 7.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 21 IAAITFLTMLATAAAMGSAGILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAALIMISAGLI 100
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 101 GSIFMTEEWQMVALWG--VVIGLGTGMTTLVLGATVAARWFEKRRGLVVGLMTASNATGQLVFMPILASV 168
Cdd:cd17321 250 LLALLGADSSVWLLLPglVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
18-195 |
7.91e-03 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 38.23 E-value: 7.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 18 GWVIAAITFLTMLATAAAMGSAGILIDPLQREFGWT-NANISFAMA----LRLVLFGLMGPFAAAFMNQFGLRRVVAAAL 92
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKdDAQMRFKTAwvgsLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 93 IMISAGLIGSIFMTEEWQMVALWGVVIGLGTGMT---TLVlgatVAARWFEKRRGLVVGLMTASNATGQLVFMPILASVS 169
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAyqpSLV----ILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLL 156
|
170 180
....*....|....*....|....*.
gi 552152457 170 QTIGWRTSLAIVIVFlltalMLVLIL 195
Cdd:cd17464 157 DSVGLFNTLRVLCIF-----MFVLFL 177
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
13-337 |
8.09e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.05 E-value: 8.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 13 RNIHYGWVIAAITFLTMLATAAamgsagILIDPLQREFGWTNANISFAMALRLVLFGLMGPFAAAFMNQFGLRRVVAAAL 92
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSP------LAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 93 IMISAGLIGSIFMTEEWQMVALWGVVIGLGTGmtTLVLGATVAARWFEKR-----RGLVVGLMTASNATGQLVFMPILAS 167
Cdd:TIGR00886 75 LLLAIPCLWAGLAVQSYSVLLLIRLFIGIAGG--SFASCMPWISFFFPKKiqgtaLGLAAGWGNMGGGVAQFVMPPIIGS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 168 VSQTIG------WRTSLAIVI-VFLLTALMLVLILMRDHPAdvglksfGRLAPLPepeprksfgAMLASPLVTLREASSt 240
Cdd:TIGR00886 153 LIFGGGqpahlaWGWAFVIVPaGILLLPALLIFFVGADTPP-------GKPATGK---------LSFKEALKVFGNRHT- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552152457 241 ptfWVLFLTFFVCGFSTNGLIQTHWISLCGDFGIAPVGAAGILAVIGAFDLIGTIMSGWLSDRFDNRWLLFWFYALRGLS 320
Cdd:TIGR00886 216 ---WILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMG 292
|
330
....*....|....*..
gi 552152457 321 LIYLTFTDFSVYELALF 337
Cdd:TIGR00886 293 AFLVVLGLVSDGSLAAF 309
|
|
| |
