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Conserved domains on  [gi|555036834|gb|ESL81155|]
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transcriptional activator BglJ [Enterobacter roggenkampii]

Protein Classification

DNA-binding transcriptional activator BglJ( domain architecture ID 11485358)

DNA-binding transcriptional activator BglJ is a crytic transcriptional activator that acts independently of transcription factor LeuO.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 18-220 4.92e-114

DNA-binding transcriptional activator BglJ; Provisional


:

Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 324.39  E-value: 4.92e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  18 MSAVGLQHLFAMPGLSHYQLHLFSEFDSFKNALHHVNFFSLIYSLSDAREERRNCLAHLRDLAFTHGHIQRIILVSDEME 97
Cdd:PRK11475   1 MSSIGIESLFRKFPGNPYKLHTFSSQSSFQDAMSRISFSAVIFSLSAMRSERREGLSCLTELAIKFPRMRRLVIADDDIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  98 ARLISHLSPSRLHGVVSKSVTLEHLQKELVELLSETLRINDNMLNHWYRSQNRMLSPTERAILRYMSCGYSIPEIAAQLE 177
Cdd:PRK11475  81 ARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQSRMLSPTEREILRFMSRGYSMPQIAEQLE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 555036834 178 RNIKTIRAHKFNAMVKLGVNSDVGLLDAADIITHLPAREPQCL 220
Cdd:PRK11475 161 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLCLRHCEASNV 203
 
Name Accession Description Interval E-value
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 18-220 4.92e-114

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 324.39  E-value: 4.92e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  18 MSAVGLQHLFAMPGLSHYQLHLFSEFDSFKNALHHVNFFSLIYSLSDAREERRNCLAHLRDLAFTHGHIQRIILVSDEME 97
Cdd:PRK11475   1 MSSIGIESLFRKFPGNPYKLHTFSSQSSFQDAMSRISFSAVIFSLSAMRSERREGLSCLTELAIKFPRMRRLVIADDDIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  98 ARLISHLSPSRLHGVVSKSVTLEHLQKELVELLSETLRINDNMLNHWYRSQNRMLSPTERAILRYMSCGYSIPEIAAQLE 177
Cdd:PRK11475  81 ARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQSRMLSPTEREILRFMSRGYSMPQIAEQLE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 555036834 178 RNIKTIRAHKFNAMVKLGVNSDVGLLDAADIITHLPAREPQCL 220
Cdd:PRK11475 161 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLCLRHCEASNV 203
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 150-206 7.76e-13

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 61.00  E-value: 7.76e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 555036834   150 RMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 152-206 8.38e-12

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 58.31  E-value: 8.38e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 555036834 152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 150-206 6.77e-11

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.98  E-value: 6.77e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 555036834 150 RMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:COG2197   68 RLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLA 124
GerE pfam00196
Bacterial regulatory proteins, luxR family;
152-206 2.01e-09

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 51.82  E-value: 2.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 555036834  152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
 
Name Accession Description Interval E-value
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 18-220 4.92e-114

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 324.39  E-value: 4.92e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  18 MSAVGLQHLFAMPGLSHYQLHLFSEFDSFKNALHHVNFFSLIYSLSDAREERRNCLAHLRDLAFTHGHIQRIILVSDEME 97
Cdd:PRK11475   1 MSSIGIESLFRKFPGNPYKLHTFSSQSSFQDAMSRISFSAVIFSLSAMRSERREGLSCLTELAIKFPRMRRLVIADDDIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  98 ARLISHLSPSRLHGVVSKSVTLEHLQKELVELLSETLRINDNMLNHWYRSQNRMLSPTERAILRYMSCGYSIPEIAAQLE 177
Cdd:PRK11475  81 ARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQSRMLSPTEREILRFMSRGYSMPQIAEQLE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 555036834 178 RNIKTIRAHKFNAMVKLGVNSDVGLLDAADIITHLPAREPQCL 220
Cdd:PRK11475 161 RNIKTIRAHKFNVMSKLGVSSDAGLLDAADILLCLRHCEASNV 203
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 150-206 7.76e-13

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 61.00  E-value: 7.76e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 555036834   150 RMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 152-206 8.38e-12

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 58.31  E-value: 8.38e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 555036834 152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYA 55
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 149-204 1.29e-11

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 61.77  E-value: 1.29e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 555036834 149 NRMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLD 204
Cdd:PRK10840 148 DKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLN 203
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 150-206 6.77e-11

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.98  E-value: 6.77e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 555036834 150 RMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:COG2197   68 RLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLA 124
GerE pfam00196
Bacterial regulatory proteins, luxR family;
152-206 2.01e-09

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 51.82  E-value: 2.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 555036834  152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
32-206 2.55e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 55.15  E-value: 2.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834  32 LSHYQLHLFSEFDSFKNALHHVNFFSLIYSLSDAREERRNCLAHLRDLAFTHGHIQRIILVSDEMEARLISHLSPSRLHG 111
Cdd:COG2771    8 LLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555036834 112 VVSKSVTLEHLQKELVELLSETLRINDNMLNHWYRSQNRMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAM 191
Cdd:COG2771   88 LALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIY 167

                        170
                 ....*....|....*
gi 555036834 192 VKLGVNSDVGLLDAA 206
Cdd:COG2771  168 RKLGVSSRAELVALA 182
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
131-206 1.35e-07

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 50.26  E-value: 1.35e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555036834 131 SETLRINDNMLNHWYRSQNRMLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:PRK09935 129 SETLNYIKSNKCSTNSSTDTVLSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYA 204
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 152-198 3.41e-05

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 40.71  E-value: 3.41e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 555036834 152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNS 198
Cdd:COG5905   13 LTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRN 59
PRK10360 PRK10360
transcriptional regulator UhpA;
152-202 4.97e-05

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 42.66  E-value: 4.97e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 555036834 152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGL 202
Cdd:PRK10360 138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVEL 188
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 152-203 9.31e-05

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 42.01  E-value: 9.31e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 555036834 152 LSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLL 203
Cdd:COG4566  138 LTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELV 189
PRK15369 PRK15369
two component system response regulator;
151-203 1.90e-04

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 41.22  E-value: 1.90e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 555036834 151 MLSPTERAILRYMSCGYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLL 203
Cdd:PRK15369 149 LLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELL 201
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 150-194 1.50e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 35.51  E-value: 1.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 555036834  150 RMLSPTERAI--LRYMsCGYSIPEIAAQLERNIKTIRAHKFNAMVKL 194
Cdd:pfam08281   9 EELPPRQREVflLRYL-EGLSYAEIAELLGISEGTVKSRLSRARKKL 54
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 152-194 2.56e-03

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 37.67  E-value: 2.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 555036834 152 LSPTERAI--LRYMsCGYSIPEIAAQLERNIKTIRAHKFNAMVKL 194
Cdd:COG1595  128 LPPRQREVlvLRYL-EGLSYAEIAEILGISEGTVKSRLSRARKKL 171
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
166-206 2.95e-03

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 37.38  E-value: 2.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 555036834 166 GYSIPEIAAQLERNIKTIRAHKFNAMVKLGVNSDVGLLDAA 206
Cdd:COG2909  137 GLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARA 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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