NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|555205067|gb|ESN47426|]
View 

response regulator receiver protein [Enterobacter sp. MGH 16]

Protein Classification

response regulator transcription factor( domain architecture ID 11468274)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; it receives the signal from the sensor partner, binds DNA upon phosphorylation, and functions as a transcriptional regulator

CATH:  3.40.50.2300|1.10.10.10
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677|GO:0006355
PubMed:  20226724|15808743|10966457
SCOP:  4003632

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-124 7.38e-30

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 105.95  E-value: 7.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAVpPPPVLFISG 86
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAA-LDPDRPGCLLLDVRMPGMSGLELQEELAARGS-PLPVIFLTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:COG4566   80 HGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALAR 117
 
Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-124 7.38e-30

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 105.95  E-value: 7.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAVpPPPVLFISG 86
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAA-LDPDRPGCLLLDVRMPGMSGLELQEELAARGS-PLPVIFLTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:COG4566   80 HGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALAR 117
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 7-122 6.72e-29

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 101.13  E-value: 6.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSGAALViTDIKLRGMSGLELFDKLRLLAVpPPPVLFISG 86
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLV-LDVRMPGMSGLELQDELLARGS-NIPIIFITG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQREL 122
Cdd:cd17537   81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-119 1.14e-23

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 87.98  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067    7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISG 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALEL-LKEERPDLILLDINMPGMDGLELLKRIRRRD-PTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 555205067   87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQ 119
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
fixJ PRK09390
response regulator FixJ; Provisional
 9-126 1.23e-22

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 87.75  E-value: 1.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAVPPPpVLFISGHA 88
Cdd:PRK09390   8 VVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDA-LPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLP-VIVMTGHG 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  89 DENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:PRK09390  86 DVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAP 123
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 6-59 3.12e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.40  E-value: 3.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 555205067     6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKL 59
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALEL-LKEEKPDLILLDIMM 54
 
Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 7-124 7.38e-30

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 105.95  E-value: 7.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAVpPPPVLFISG 86
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAA-LDPDRPGCLLLDVRMPGMSGLELQEELAARGS-PLPVIFLTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:COG4566   80 HGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALAR 117
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 7-122 6.72e-29

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 101.13  E-value: 6.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSGAALViTDIKLRGMSGLELFDKLRLLAVpPPPVLFISG 86
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLV-LDVRMPGMSGLELQDELLARGS-NIPIIFITG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQREL 122
Cdd:cd17537   81 HGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-126 6.66e-28

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 105.43  E-value: 6.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFIS 85
Cdd:COG2204    4 RILVVDDDPDIRRLLKELLERAGYEVETAASGEEALAL-LREEPPDLVLLDLRMPGMDGLELLRELRALD-PDLPVILLT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRR 122
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 7-126 1.25e-25

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 93.32  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISG 86
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAA-LSPDFPGVVISDIRMPGMDGLELLAQIRELD-PDLPVILITG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:cd17549   79 HGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRR 118
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 6-126 1.00e-23

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 88.37  E-value: 1.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAV-PPPPVLFI 84
Cdd:COG0784    7 RILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALEL-LRAGPPDLILLDINMPGMDGLELLRRIRALPRlPDIPIIAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  85 SGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:COG0784   86 TAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARAS 127
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 7-119 1.14e-23

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 87.98  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067    7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISG 86
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALEL-LKEERPDLILLDINMPGMDGLELLKRIRRRD-PTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 555205067   87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQ 119
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
fixJ PRK09390
response regulator FixJ; Provisional
 9-126 1.23e-22

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 87.75  E-value: 1.23e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAVPPPpVLFISGHA 88
Cdd:PRK09390   8 VVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDA-LPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLP-VIVMTGHG 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  89 DENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:PRK09390  86 DVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAP 123
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 9-108 1.12e-21

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 82.28  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISGHA 88
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEALEL-LREERPDLVLLDLMMPGMDGLELLRKLRELP-PDIPVIVLTAKA 79

                         90       100
                 ....*....|....*....|
gi 555205067  89 DENMQRYALGLGAAAFLRKP 108
Cdd:cd00156   80 DEEDAVRALELGADDYLVKP 99
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 6-126 1.09e-20

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 82.70  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRllAVPPP-PVLFI 84
Cdd:COG0745    3 RILVVEDDPDIRELLADALEREGYEVDTAADGEEALEL-LEEERPDLILLDLMLPGMDGLEVCRRLR--ARPSDiPIIML 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  85 SGHADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARRQ 126
Cdd:COG0745   80 TARDDEEDRVRGLEAGADDYLTKPFDPEELLARI-RALLRRR 120
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-126 1.43e-20

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 82.91  E-value: 1.43e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAVPP-PPVLFI 84
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALEL-LLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRdIPVIFL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  85 SGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:COG3437   87 TALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRR 128
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 7-123 2.02e-20

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 79.46  E-value: 2.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISG 86
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKL-IKERRPDLVLLDIWLPDMDGLELLKEIKEKY-PDLPVIMISG 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIQRELA 123
Cdd:cd17550   79 HGTIETAVKATKLGAYDFIEKPLSLDRLLLTIERALE 115
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 4-118 6.08e-20

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 79.95  E-value: 6.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   4 PWRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLR-LLAVPPPPVL 82
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALEL-LQEHRPDLILLDLEMPDMDGLELCRRLRaDPRTADIPII 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 555205067  83 FISGHADENMQRYALGLGAAAFLRKPINIDILLDHI 118
Cdd:COG3706   80 FLTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 6-108 1.87e-18

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 74.42  E-value: 1.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESE-GYST-DTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLF 83
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEaGFEVvGEAENGEEALEL-LEEHKPDLVITDINMPGMDGLELLEAIRELD-PDTKIII 78

                         90       100
                 ....*....|....*....|....*
gi 555205067  84 ISGHADENMQRYALGLGAAAFLRKP 108
Cdd:COG4753   79 LSGYSDFEYAQEAIKLGADDYLLKP 103
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 9-120 6.59e-17

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 70.83  E-value: 6.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDTFDSA-------EVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRLLAvPPPPV 81
Cdd:cd17536    3 IVDDEPLIREGLKKLIDWEELGFEVVGEAengeealELIEEHK-----PDIVITDIRMPGMDGLELIEKIRELY-PDIKI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  82 LFISGHAD-ENMQRyALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17536   77 IILSGYDDfEYAQK-AIRLGVVDYLLKPVDEEELEEALEK 115
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 6-120 3.21e-14

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 63.83  E-value: 3.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRlLAVPPPPVLFIS 85
Cdd:cd19919    2 TVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAA-LASSQPDVLISDIRMPGMDGLALLAQIK-QRHPDLPVIIMT 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd19919   80 AHSDLDSAVSAYQGGAFEYLPKPFDIDEAVALVER 114
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-120 9.09e-14

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 64.84  E-value: 9.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLES-EGYS-TDTFDSAEVFLSHPLALSgAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLF 83
Cdd:COG3279    3 KILIVDDEPLARERLERLLEKyPDLEvVGEASNGEEALELLEEHK-PDLVFLDIQMPGLDGFELARQLRELD-PPPPIIF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  84 ISGHADenmqrYAL---GLGAAAFLRKPINIDILLDHIQR 120
Cdd:COG3279   81 TTAYDE-----YALeafEVNAVDYLLKPIDEERLAKALEK 115
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 7-108 1.10e-13

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 62.08  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLsHPLALSGAALVITDIKLRGMSGLELFDKLRllAVPPPPVLFISG 86
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASAL-DGLNARPPDLAILDIKMPRMDGMELLQRLR--QKSTLPVIFLTS 77

                         90       100
                 ....*....|....*....|..
gi 555205067  87 HADENMQRYALGLGAAAFLRKP 108
Cdd:cd19936   78 KDDEIDEVFGLRMGADDYITKP 99
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 4-126 1.42e-13

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 62.68  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   4 PWRIAIIDDERSVRSGLSNLLES-EGYST-DTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPV 81
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERlPGFEVvGVASSGEEALAL-LAEHRPDLILLDIYLPDGDGLELLRELRARG-PDVDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRR 125
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 6-110 2.32e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 61.69  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYS-----TDTFDSAEVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRllAVPP-- 78
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLevvsfTDPREALAWCRENP-----PDLILLDYMMPGMDGLEFIRRLR--ALPGle 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 555205067  79 -PPVLFISGHADENMQRYALGLGAAAFLRKPIN 110
Cdd:cd17551   75 dVPIVMITADTDREVRLRALEAGATDFLTKPFD 107
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 10-118 2.93e-13

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 61.10  E-value: 2.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067  10 IDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHplaLSGAA----LVITDIKLRGMSGLELFDKLRLlaVPPPPVLFIS 85
Cdd:cd17584    4 VDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSM---LRENKdefdLVITDVHMPDMDGFEFLELIRL--EMDLPVIMMS 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINID---ILLDHI 118
Cdd:cd17584   79 ADGSTSTVMKGLAHGACDYLLKPVSIEdlkNIWQHV 114
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-124 4.29e-13

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 62.24  E-value: 4.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLaVPPPPVLFIS 85
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALAL-LEQAPPDYAVLDLRLGDGSGLDLIEALRER-DPDARIVVLT 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:COG4567   84 GYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGD 122
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 4-126 6.91e-13

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 61.90  E-value: 6.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   4 PWRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSGAALVITDIKLRGMSGLELFDKLRllAVPPPPVLF 83
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQIS--EERPAPVIL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  84 ISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFR 123
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 7-120 1.69e-12

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 59.45  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEG-----YSTDTFDSA-EVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRLLAvPPPP 80
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPdievvGEAADGEEAlALLRELR-----PDVVLMDLSMPGMDGIEALRRLRRRY-PDLK 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17535   75 VIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRA 114
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 9-108 1.75e-12

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 58.96  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLshPLALSGA-ALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISGH 87
Cdd:cd17574    2 VVEDDEEIAELLSDYLEKEGYEVDTAADGEEAL--ELAREEQpDLIILDVMLPGMDGFEVCRRLREKG-SDIPIIMLTAK 78

                         90       100
                 ....*....|....*....|.
gi 555205067  88 ADENMQRYALGLGAAAFLRKP 108
Cdd:cd17574   79 DEEEDKVLGLELGADDYITKP 99
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 6-108 2.46e-12

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 58.67  E-value: 2.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFIS 85
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDIDIVVTDIVMPEMDGIELAREARKID-PDVKILFIS 79

                         90       100
                 ....*....|....*....|...
gi 555205067  86 GHADENMQRYALGLGAAAFLRKP 108
Cdd:cd18160   80 GGAAAAPELLSDAVGDNATLKKP 102
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 6-120 8.33e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 57.70  E-value: 8.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYS-TDTFDSAEvflshplALSGAA-----LVITDIKLRGMSGLELFDKLRLLAV-PP 78
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEvVEAADGRD-------ALSKAQskkfdLIITDQNMPNMDGIELIKELRKLPAyKF 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  79 PPVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17562   75 TPILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKK 116
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 6-123 9.18e-12

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 57.42  E-value: 9.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYS-TDTFDSAE-----VFLSHPlalsgaALVITDIKLRG-MSGLELFDKLRLLAvpP 78
Cdd:cd17534    2 KILIVEDEAIIALDLKEILESLGYEvVGIADSGEeaielAEENKP------DLILMDINLKGdMDGIEAAREIREKF--D 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  79 PPVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIqrELA 123
Cdd:cd17534   74 IPVIFLTAYSDEETLERAKETNPYGYLVKPFNERELKAAI--ELA 116
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 6-123 2.41e-11

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 56.26  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvpPPPV-LFI 84
Cdd:cd17569    2 TILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEI-LKQEPVDVVISDQRMPGMDGAELLKRVRERY--PDTVrILL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  85 SGHADENMQRYALGLGAA-AFLRKPINIDILLDHIQRELA 123
Cdd:cd17569   79 TGYADLDAAIEAINEGEIyRFLTKPWDDEELKETIRQALE 118
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 6-120 5.14e-10

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 52.97  E-value: 5.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGY----STDTFDSAEVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRLLAvPPPPV 81
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDSGFqvlqAADGRQGLELFRSEQ-----PDLVLCDLRMPEMDGLEVLKQITKES-PDTPV 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPI-NIDILLDHIQR 120
Cdd:cd17555   76 IVVSGAGVMSDAVEALRLGAWDYLTKPIeDLAVLEHAVRR 115
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 4-126 5.36e-10

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 55.65  E-value: 5.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   4 PWRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLsHPLALSGAALVITDIKLRGMSGLELFDKLRLlAVPPPPVLF 83
Cdd:PRK10923   3 RGIVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVL-EALASKTPDVLLSDIRMPGMDGLALLKQIKQ-RHPMLPVII 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  84 ISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:PRK10923  81 MTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQ 123
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 7-122 1.37e-09

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 51.90  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSgAALVITDIKLRGMSGLELFDKLRllAVPPPPVLFISG 86
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFK-PDLVLLDINLPYFDGFYWCREIR--QISNVPIIFISS 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 555205067  87 hADENM-QRYALGLGAAAFLRKPINIDILLDHIQREL 122
Cdd:cd18159   78 -RDDNMdQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 7-125 1.81e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 51.54  E-value: 1.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLShpLALSGA-ALVITDIKLRGMSGLELFDKLRllAVPPPPVLFIS 85
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLA--ALLEGSpDLVVLDVMLPKMNGLDVLKELR--KTSQVPVLMLT 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINidilldhiQRELARR 125
Cdd:cd17623   77 ARGDDIDRILGLELGADDYLPKPFN--------PRELVAR 108
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 6-120 3.26e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 50.68  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFIS 85
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEK-LESEDPDLVILDIKMPGMDGLETLRKIREKK-PDLPVIICT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 555205067  86 G--HADENMQRYAlglgAAAFLRKPINIDILLDHIQR 120
Cdd:cd17554   80 AysEYKSDFSSWA----ADAYVVKSSDLTELKETIKR 112
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 7-118 4.08e-09

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 50.55  E-value: 4.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSA----EVFLSHPLalsgaALVITDIKLRGMSGLELFDKLRLLAV--PPPP 80
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGqealELLKEEPF-----DLVLMDLQMPVMDGLEATRRIRELEGggRRTP 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHI 118
Cdd:cd17546   76 IIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-125 9.18e-09

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 51.50  E-value: 9.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   1 MTLPwRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPP 80
Cdd:PRK11083   1 MQQP-TILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDK-LRQQPPDLVILDVGLPDISGFELCRQLLAFH-PALP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINidilldhiQRELARR 125
Cdd:PRK11083  78 VIFLTARSDEVDRLVGLEIGADDYVAKPFS--------PREVAAR 114
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 7-119 1.02e-08

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 49.33  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLShpLA-LSGAALVITDIKLRGMSGLELFDKLRLLAVPPPpVLFIS 85
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLD--LGkLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTP-ILILS 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIQ 119
Cdd:cd17616   78 GLADIEDKVKGLGFGADDYMTKPFHKDELVARIH 111
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 6-122 1.15e-08

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 49.47  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYST----DTFDSAEVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRLLAvPPPPV 81
Cdd:cd17553    2 KILIVDDQYGIRILLNEVFNKEGYQTfqaaNGLQALDIVTKER-----PDLVLLDMKIPGMDGIEILKRMKVID-ENIRV 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQREL 122
Cdd:cd17553   76 IIMTAYGELDMIQESKELGALTHFAKPFDIDEIRDAVKKYL 116
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
1-125 1.60e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.39  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   1 MTLPWRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPP 80
Cdd:PRK11361   1 MTAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHL-FADIHPDVVLMDIRMPEMDGIKALKEMRSHE-TRTP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARR 125
Cdd:PRK11361  79 VILMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQ 123
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 6-124 6.03e-08

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 47.41  E-value: 6.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGY-----STDTFDSAEVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRllAVPPPP 80
Cdd:cd19932    2 RVLIAEDEALIRMDLREMLEEAGYevvgeASDGEEAVELAKKHK-----PDLVIMDVKMPRLDGIEAAKIIT--SENIAP 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:cd19932   75 IVLLTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
PRK15115 PRK15115
response regulator GlrR; Provisional
 4-125 1.13e-07

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 48.68  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   4 PWRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLsHPLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLF 83
Cdd:PRK15115   5 PAHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEAL-RVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQ-PGMPVII 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  84 ISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARR 125
Cdd:PRK15115  83 LTAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQS 124
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 7-126 1.28e-07

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 46.81  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDS---AEVFLSHplalSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLF 83
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETgkeALAFLSD----QPPDVVLLDLKLPDMSGMEILKWIQERS-LPTSVIV 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  84 ISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:cd17572   76 ITAHGSVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNALKHRK 118
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 9-125 1.36e-07

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 46.45  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDT-FDSAEVFLshpLALSGA-ALVITDIKLRGMSGLELFDKLRLLAVpPPPVLFISG 86
Cdd:cd17625    2 VVEDEKDLSEAITKHLKKEGYTVDVcFDGEEGLE---YALSGIyDLIILDIMLPGMDGLEVLKSLREEGI-ETPVLLLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 555205067  87 HADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:cd17625   78 LDAVEDRVKGLDLGADDYLPKPFSLAELLARI-RALLRR 115
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 6-120 1.69e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 46.38  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLShpLALSGA-ALVITDIKLRGMSGLELfdkLRLLAVPPP----P 80
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALE--IARKEKpDLILMDIQLPGMDGLEA---TRLLKEDPAtrdiP 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17548   76 VIALTAYAMKGDREKILEAGCDGYISKPIDTREFLETVAK 115
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 7-116 2.25e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 45.91  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEvflshpLALSGAA-----LVITDIKLRGMSGLELFDKLRLLavPP--- 78
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGE------EALEAAQrfrpdVILSDIGMPGMDGYELARRLREL--PWlan 72

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 555205067  79 PPVLFISGHA-DENMQRyALGLGAAAFLRKPINIDILLD 116
Cdd:cd17580   73 TPAIALTGYGqPEDRER-ALEAGFDAHLVKPVDPDELIE 110
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 7-108 2.59e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 45.42  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSGAALVITDIKL-RGMSGLELFDKLRLLAvPPPPVLFIS 85
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGPDIDLLVTDVIMpGGMNGSQLAEEARRRR-PDLKVLLTS 79

                         90       100
                 ....*....|....*....|...
gi 555205067  86 GHAdENMQRYALGLGAAAFLRKP 108
Cdd:cd18161   80 GYA-ENAIEGGDLAPGVDVLSKP 101
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 7-108 3.03e-07

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 45.27  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRllAVPPPPVLFISG 86
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAE-FDRAGADIVLLDLMLPGLSGTEVCRQLR--ARSNVPVIMVTA 77

                         90       100
                 ....*....|....*....|..
gi 555205067  87 HADENMQRYALGLGAAAFLRKP 108
Cdd:cd17621   78 KDSEIDKVVGLELGADDYVTKP 99
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 9-115 4.09e-07

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 45.34  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSgAALVITDIKLRGMSGLELFDKLRLLAVPPP-PVLFISGH 87
Cdd:cd19937    2 VVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEK-PDLIILDLMLPGIDGLEVCRILRSDPKTSSiPIIMLTAK 80

                         90       100
                 ....*....|....*....|....*...
gi 555205067  88 ADENMQRYALGLGAAAFLRKPINIDILL 115
Cdd:cd19937   81 GEEFDKVLGLELGADDYITKPFSPRELL 108
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 7-108 8.05e-07

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 44.08  E-value: 8.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEvflshpLALSGAA-----LVITDIKLRGMSGLELFDKLRLLAvpPPPV 81
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQ------EGLLEAAtrkpdLIILDLGLPDMDGLEVIRRLREWS--AVPV 72

                         90       100
                 ....*....|....*....|....*..
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKP 108
Cdd:cd17620   73 IVLSARDEESDKIAALDAGADDYLTKP 99
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 7-119 1.04e-06

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 44.36  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGY----STDTFDSAEVFLSHPLALsgaalVITDIKLRGMSGLELFDKLRllAVPPPPVL 82
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFdvtaAADGAEEARLMLHRRVDL-----VLLDLRLGQESGLDLLRTIR--ARSDVPII 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  83 FISGHADENMQR-YALGLGAAAFLRKPINIDILLDHIQ 119
Cdd:cd17594   75 IISGDRRDEIDRvVGLELGADDYLAKPFGLRELLARVR 112
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 6-125 1.10e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 44.30  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGystdtfdSAEVFLShplALSGA-AL---------VIT-DIKLRGMSGLELFDklRLL 74
Cdd:cd17541    2 RVLIVDDSAVMRKLLSRILESDP-------DIEVVGT---ARDGEeALekikelkpdVITlDIEMPVMDGLEALR--RIM 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 555205067  75 AVPPPPVLFISGHADENMQRY--ALGLGAAAFLRKP-INIDILLDHIQRELARR 125
Cdd:cd17541   70 AERPTPVVMVSSLTEEGAEITleALELGAVDFIAKPsGGISLDLEEIAEELIEK 123
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 6-115 1.39e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 43.91  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVfLSHPLALSGAALVITDIKLRGMSGLELFDKLRLLAvpPPPVLFIS 85
Cdd:cd17619    2 HILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEE-MRQILARQDIDLVLLDINLPGKDGLSLTRELREQS--EVGIILVT 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILL 115
Cdd:cd17619   79 GRDDEVDRIVGLEIGADDYVTKPFNPRELL 108
PRK11173 PRK11173
two-component response regulator; Provisional
 1-125 1.44e-06

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 45.39  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   1 MTLPwRIAIIDDERSVRSGLSNLLESEGYST-DTFDSAEvfLSHPLALSGAALVITDIKLRGMSGLELFDKLRLLAvpPP 79
Cdd:PRK11173   1 MQTP-HILIVEDELVTRNTLKSIFEAEGYDVfEATDGAE--MHQILSENDINLVIMDINLPGKNGLLLARELREQA--NV 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 555205067  80 PVLFISGHADENMQRYALGLGAAAFLRKPINidilldhiQRELARR 125
Cdd:PRK11173  76 ALMFLTGRDNEVDKILGLEIGADDYITKPFN--------PRELTIR 113
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
1-120 2.01e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 45.50  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067    1 MTLPWRIAII--DDERSVRSGLSNLLESEGYSTD-TFDSAEVFlsHPLALSGAALVITDIKLRGMSGLELFDKLRLLAvP 77
Cdd:PRK09959  953 ITLPEKLSILiaDDHPTNRLLLKRQLNLLGYDVDeATDGVQAL--HKVSMQHYDLLITDVNMPNMDGFELTRKLREQN-S 1029

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 555205067   78 PPPVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:PRK09959 1030 SLPIWGLTANAQANEREKGLSCGMNLCLFKPLTLDVLKTHLSQ 1072
PRK10360 PRK10360
transcriptional regulator UhpA;
7-115 2.03e-06

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 44.58  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNL--LESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKL-RLLAvppppVLF 83
Cdd:PRK10360   4 VALIDDHLIVRSGFAQLlgLEPDLQVVAEFGSGREALAG-LPGRGVQVCICDISMPDISGLELLSQLpKGMA-----TIM 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 555205067  84 ISGHADENMQRYALGLGAAAFLRKPINIDILL 115
Cdd:PRK10360  78 LSVHDSPALVEQALNAGARGFLSKRCSPDELI 109
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 7-124 2.95e-06

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 44.41  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYstdtfdsaEVFLSHPL--ALSGAA-----LVITDIKLRGMSGLELFDKLRLLAvpPP 79
Cdd:PRK10529   4 VLIVEDEQAIRRFLRTALEGDGM--------RVFEAETLqrGLLEAAtrkpdLIILDLGLPDGDGIEFIRDLRQWS--AI 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  80 PVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:PRK10529  74 PVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRR 118
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 6-59 3.12e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.40  E-value: 3.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 555205067     6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKL 59
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALEL-LKEEKPDLILLDIMM 54
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 7-109 3.91e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 42.50  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVflshplALSGAA-----LVITDIKLRGMSGLELFDKLRllAVPPP-- 79
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQ------ALQRAQaeppdLILLDVMMPGMDGFEVCRRLK--ADPATrh 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 555205067  80 -PVLFISGHADENMQRYALGLGAAAFLRKPI 109
Cdd:cd19920   73 iPVIFLTALTDTEDKVKGFELGAVDYITKPF 103
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-108 4.45e-06

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 42.51  E-value: 4.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYST----DTFDSAEVFLSHPlalsGAALVITDIKLRGMSGLELFDKLRL------LA 75
Cdd:cd17544    2 KVLVVDDSATSRNHLRALLRRHNFQVleaaNGQEALEVLEQHP----DIKLVITDYNMPEMDGFELVREIRKkysrdqLA 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 555205067  76 vppppVLFISGHADENMQRYALGLGAAAFLRKP 108
Cdd:cd17544   78 -----IIGISASGDNALSARFIKAGANDFLTKP 105
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 6-124 9.67e-06

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 41.59  E-value: 9.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTF----DSAEVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRLLAvpPPPV 81
Cdd:cd19939    1 RILIVEDELELARLTRDYLIKAGLEVSVFtdgqRAVRRIIDEQ-----PSLVVLDIMLPGMDGLTVCREVREHS--HVPI 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:cd19939   74 LMLTARTEEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 6-115 1.05e-05

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 41.27  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFIS 85
Cdd:cd17563    2 SLLLVDDDEVFAERLARALERRGFEVETAHSVEEALAL-AREEKPDYAVLDLRLGGDSGLDLIPPLRALQ-PDARIVVLT 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILL 115
Cdd:cd17563   80 GYASIATAVEAIKLGADDYLAKPADADEIL 109
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 6-119 1.34e-05

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 41.47  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLR----LLAVpppPV 81
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNL-IVEPRPDLILLDWMLPGGSGIQFIRRLKrdemTRDI---PI 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQ 119
Cdd:cd17618   78 IMLTARGEEEDKVRGLEAGADDYITKPFSPRELVARIK 115
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 6-114 1.73e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 41.17  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYS--TDTFDSAEVF--LSHPlalsGAALVITDIKLRGMSGLELFDKLR----LLAVp 77
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKELGFNnvEEAEDGVDALekLKAG----GFDFVITDWNMPNMDGLELLKTIRadgaLSHL- 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 555205067  78 ppPVLFISGHADENMQRYALGLGAAAFLRKPINIDIL 114
Cdd:cd19923   77 --PVLMVTAEAKKENVIAAAQAGVNNYIVKPFTAATL 111
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 7-108 1.76e-05

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 40.82  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALSGAA--------LVITDIKLRGMSGLELFDKLRL-LAVP 77
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLENLAKEGndlskeldLIITDIEMPKMDGYELTFELRDdPRLA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 555205067  78 PPPVLFISGHADENMQRYALGLGAAAFLRKP 108
Cdd:cd19924   81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 7-108 1.85e-05

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 40.50  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLShpLALSGA-ALVITDIKLRGMSGLELFDKLRlLAVPPPPVLFIS 85
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLH--LALTNEyDLIILDVMLPGLDGLEVLRRLR-AAGKQTPVLMLT 77

                         90       100
                 ....*....|....*....|...
gi 555205067  86 GHADENMQRYALGLGAAAFLRKP 108
Cdd:cd19935   78 ARDSVEDRVKGLDLGADDYLVKP 100
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 6-122 2.12e-05

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 41.00  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESE-GYSTDTFDSAEVflshplALSGAA-----LVITDIKLRGMSGLELFDKLRllAVP-- 77
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLaGWEVLTASSGQE------GLEKAAteqpdAILLDVMMPDMDGLATLKKLQ--ANPet 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 555205067  78 -PPPVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQREL 122
Cdd:cd17552   75 qSIPVILLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 7-125 2.69e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 40.44  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDT-FDSAEvflshplALSGAA-----LVITDIKLRGMSGLELFDKLRlLAVPPPP 80
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETaVDGAE-------ALRVISgnrpdAVVLDVMMPRLDGLEVCRRLR-AAGNDLP 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:cd17627   73 ILVLTARDSVSDRVAGLDAGADDYLVKPFALEELLARV-RALLRR 116
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 4-67 3.38e-05

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 40.26  E-value: 3.38e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555205067   4 PWRIAIIDDERSVRSGLSNLLESEGYST--DTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLEL 67
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEvvGEAADGEEALEL-LEELRPDVVLLDIRMPGMDGLEA 65
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
7-126 5.35e-05

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 41.17  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHplaLSGAA--LVITDIKLRGMSGLELFDKLRLLAvPPPPVLFI 84
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQ---VREQVfdLVLCDVRMAEMDGIATLKEIKALN-PAIPVLIM 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  85 SGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARRQ 126
Cdd:PRK10365  84 TAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTH 125
PRK15479 PRK15479
transcriptional regulator TctD;
6-125 5.99e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 40.48  E-value: 5.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTD-TFDSaeVFLSHPLALSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFI 84
Cdd:PRK15479   2 RLLLAEDNRELAHWLEKALVQNGFAVDcVFDG--LAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRG-QTLPVLLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 555205067  85 SGHADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:PRK15479  79 TARSAVADRVKGLNVGADDYLPKPFELEELDARL-RALLRR 118
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
6-124 6.03e-05

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 40.86  E-value: 6.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYS---TDTFDSAEVFLSHPLalsgAALVITDIKLRGMSGLELFDKLRLLAVPPP-PV 81
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQNGFQpveAEDYDSAVNQLNEPW----PDLILLDWMLPGGSGIQFIKHLKRESMTRDiPV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:PRK10161  80 VMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRR 122
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-120 6.27e-05

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 40.40  E-value: 6.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   1 MTLPWRIAIIDDERSVRSGLSNLLESEgystDTFDSAEVFLSHPLALSGAA-----LVITDIKLRGMSGLELFDKLRLLA 75
Cdd:PRK10651   3 NQEPATILLIDDHPMLRTGVKQLISMA----PDITVVGEASNGEQGIELAEsldpdLILLDLNMPGMNGLETLDKLREKS 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 555205067  76 VPPPPVLF-ISGHADENMQryALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:PRK10651  79 LSGRIVVFsVSNHEEDVVT--ALKRGADGYLLKDMEPEDLLKALQQ 122
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 6-125 6.49e-05

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 39.64  E-value: 6.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHPLALsGAALVITDIKLRGMSGLELFDKLRlLAVPPPPVLFIS 85
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREF-RPDAVVLDIMLPDMDGLEVLRRLR-ADGPDVPVLFLT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 555205067  86 GHaDENMQRYA-LGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:cd17615   79 AK-DSVEDRIAgLTAGGDDYVTKPFSLEEVVARL-RALLRR 117
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 7-118 7.63e-05

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 39.17  E-value: 7.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYST-DTFDSAEVFLSHpLALSGAALVITDIKL-RGMSGLELFDKLRLLAVPPPPVLFI 84
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVTRiDTASSGEEALRM-CENKTYDIVLCDYNLgKGKNGQQLLEELRHKKLISPSTVFI 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 555205067  85 --SGHADENMQRYALGLGAAAFLRKPINIDILLDHI 118
Cdd:cd17589   80 mvTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 6-120 8.54e-05

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 39.18  E-value: 8.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYS-----TDTFDSAEVFLSHplalsGAALVITDIKLRGMSGLELFDKLRLLAvPPPP 80
Cdd:cd17542    2 KVLIVDDAAFMRMMLKDILTKAGYEvvgeaANGEEAVEKYKEL-----KPDLVTMDITMPEMDGIEALKEIKKID-PNAK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17542   76 VIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEK 115
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 7-108 9.75e-05

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 38.90  E-value: 9.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSA-EVFLShpLALSGAALVITDIKLRGMSGLELFDKLRLLA-VPPPPVLFI 84
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGlEALDL--LNQYIPDLIISDIIMPGVDGYSLLGKLRKNAdFDTIPVIFL 78

                         90       100
                 ....*....|....*....|....*.
gi 555205067  85 S--GHADENMQRYalGLGAAAFLRKP 108
Cdd:cd19927   79 TakGMTSDRIKGY--NAGCDGYLSKP 102
PRK10610 PRK10610
chemotaxis protein CheY;
6-108 1.56e-04

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 38.80  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYST--DTFDSAEVFlsHPLALSGAALVITDIKLRGMSGLELFDKLRL-LAVPPPPVL 82
Cdd:PRK10610   7 KFLVVDDFSTMRRIVRNLLKELGFNNveEAEDGVDAL--NKLQAGGFGFVISDWNMPNMDGLELLKTIRAdGAMSALPVL 84

                         90       100
                 ....*....|....*....|....*.
gi 555205067  83 FISGHADENMQRYALGLGAAAFLRKP 108
Cdd:PRK10610  85 MVTAEAKKENIIAAAQAGASGYVVKP 110
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 7-122 2.92e-04

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 37.69  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKL----RLLAVpppPVL 82
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAM-LAEHRPTLVISDIVMPEMDGYELCRKIksdpDLKDI---PVI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  83 FISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQREL 122
Cdd:cd17598   77 LLTTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
PRK13557 PRK13557
histidine kinase; Provisional
 6-125 3.24e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 38.88  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSA----EVFLSHPLAlsgaALVITD-IKLRGMSGLELFDKLRLLaVPPPP 80
Cdd:PRK13557 417 TILIVDDRPDVAELARMILEDFGYRTLVASNGrealEILDSHPEV----DLLFTDlIMPGGMNGVMLAREARRR-QPKIK 491

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 555205067  81 VLFISGHADENMQRYALGLGAAAFLRKPINidilldhiQRELARR 125
Cdd:PRK13557 492 VLLTTGYAEASIERTDAGGSEFDILNKPYR--------RAELARR 528
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 7-118 4.43e-04

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 37.02  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDS---AEVFLShplaLSGAALVITDIKLRGMSGLELFDKLRllAVPPPPVLF 83
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESlkdGEYYID----IRNYDLVLVSDKLPDGNGLSIVSRIK--EKHPSIVVI 74

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 555205067  84 ISGHADENMQRY-ALGLGAAAFLRKPINIDILLDHI 118
Cdd:cd17573   75 VLSDNPKTEQEIeAFKEGADDYIAKPFDFKVLVARI 110
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
6-125 5.28e-04

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 37.86  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLShpLALSGAALVITDIKLRGMSGLELFDKLRLLAvpPPPVLFIS 85
Cdd:PRK10955   3 KILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALD--LLDDSIDLLLLDVMMPKKNGIDTLKELRQTH--QTPVIMLT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:PRK10955  79 ARGSELDRVLGLELGADDYLPKPFNDRELVARI-RAILRR 117
orf27 CHL00148
Ycf27; Reviewed
 6-124 5.64e-04

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 37.77  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLsHPLALSGAALVITDIKLRGMSGLELFDKLRllAVPPPPVLFIS 85
Cdd:CHL00148   8 KILVVDDEAYIRKILETRLSIIGYEVITASDGEEAL-KLFRKEQPDLVILDVMMPKLDGYGVCQEIR--KESDVPIIMLT 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELAR 124
Cdd:CHL00148  85 ALGDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRR 123
ompR PRK09468
osmolarity response regulator; Provisional
 6-125 5.75e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 38.03  E-value: 5.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVfLSHPLALSGAALVITDIKLRGMSGLELFDKLRlLAVPPPPVLFIS 85
Cdd:PRK09468   7 KILVVDDDMRLRALLERYLTEQGFQVRSAANAEQ-MDRLLTRESFHLMVLDLMLPGEDGLSICRRLR-SQNNPTPIIMLT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIQRELARR 125
Cdd:PRK09468  85 AKGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQ 124
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 9-109 7.18e-04

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 36.48  E-value: 7.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   9 IIDDERSVRSGLSNLLESE--GYSTDTFDSAEVFLSHPLALsGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVLFISG 86
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDdlGEVVGEADNGAQAYDEILFL-QPDIVLIDLLMPGMDGIQLVRKLKDTG-SNGKFIMISQ 80

                         90       100
                 ....*....|....*....|...
gi 555205067  87 HADENMQRYALGLGAAAFLRKPI 109
Cdd:cd17565   81 VSDKEMIGKAYQAGIEFFINKPI 103
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 5-125 8.30e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 36.58  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   5 WRIAIIDDERSVRSGLSNLLESEGY--STDTFDSAEVFLSHplalSGAALVITDIKLRGMSGLELFDKLRLLAvPPPPVL 82
Cdd:cd17596    1 PTILVVDDEVRSLEALRRTLEEDFDvlTAASAEEALAILEE----EWVQVILCDQRMPGTTGVEFLKEVRERW-PEVVRI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 555205067  83 FISGHAD-ENMQRYALGLGAAAFLRKPINIDILLDHIQ-----RELARR 125
Cdd:cd17596   76 IISGYTDsEDIIAGINEAGIYQYLTKPWHPDQLLLTVRnaarlFELQRE 124
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 51-120 8.40e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 36.63  E-value: 8.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 555205067  51 ALVITDIKLRGMSGLELF------DKLRLLAVppppVLFISGHADENMQRyALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17557   54 DLILLDLNMPRMDGFEVLreikadPDLRRIPV----VVLTTSDAEEDIER-AYELGANSYIVKPVDFEEFVEAIRS 124
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 7-125 8.81e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 36.49  E-value: 8.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVflSHPLALSGA-ALVITDIKLRGMSGLELFDKLRLLAVpPPPVLFIS 85
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEE--ALFQGEEEPyDLVVLDLGLPGMDGLSVLRRWRSEGR-ATPVLILT 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 555205067  86 GHADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:cd19934   78 ARDSWQDKVEGLDAGADDYLTKPFHIEELLARL-RALIRR 116
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 7-123 9.13e-04

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 36.56  E-value: 9.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEgystDTFDSAEVFLSHPLALSGAA-----LVITDIKLRGMSGLELFDKLRLLAVPPPPV 81
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELD----PDFTVVGEASSGEEGIELAErldpdLILLDLNMKGMSGLDTLKALREEGVSARIV 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 555205067  82 LFISGHADENMQRyALGLGAAAFLRKPINIDILLDHIQRELA 123
Cdd:cd19931   77 ILTVSDAEDDVVT-ALRAGADGYLLKDMEPEDLLEALKQAAS 117
PRK15369 PRK15369
two component system response regulator;
3-119 1.13e-03

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 36.98  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   3 LPWRIAIIDDERSVRSGLSNLLESE------GYSTDTFDSAEVFLSHPlalsgAALVITDIKLRGMSGLELFDKLRlLAV 76
Cdd:PRK15369   2 KNYKILLVDDHELIINGIKNMLAPYprykivGQVDNGLEVYNACRQLE-----PDIVILDLGLPGMNGLDVIPQLH-QRW 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  77 PPPPVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQ 119
Cdd:PRK15369  76 PAMNILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQ 118
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
2-119 1.25e-03

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 36.75  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   2 TLPWRIAIIDDERSVRSGLSNLLESEGYS---TDTFDSAEVF-LSHPLALSgaaLVITDIKLRGMSGLELFDKLRLLAVP 77
Cdd:PRK10403   4 ATPFQVLIVDDHPLMRRGVRQLLELDPGFevvAEAGDGASAIdLANRLDPD---VILLDLNMKGMSGLDTLNALRRDGVT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 555205067  78 PPPVLFISGHADENMqrYAL-GLGAAAFLRKPINIDILLDHIQ 119
Cdd:PRK10403  81 AQIIILTVSDASSDV--FALiDAGADGYLLKDSDPEVLLEAIR 121
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 6-108 1.74e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 35.43  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLSHpLALSGAALVITDIKLRGMSGLELFDKLRllAVPPPPVLFIS 85
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPY-VRHTPPDLILLDLMLPGTDGLTLCREIR--RFSDVPIIMVT 77

                         90       100
                 ....*....|....*....|...
gi 555205067  86 GHADENMQRYALGLGAAAFLRKP 108
Cdd:cd19938   78 ARVEEIDRLLGLELGADDYICKP 100
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 7-108 2.01e-03

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 35.17  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVfLSHPLALSGAALVITDIKLRGMSGLELFDKLRlLAVPPPPVLFISG 86
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAAT-LWRWVEEGEGDLVITDVVMPDENGLDLIPRIK-KARPDLPIIVMSA 78

                         90       100
                 ....*....|....*....|..
gi 555205067  87 HADENMQRYALGLGAAAFLRKP 108
Cdd:cd19928   79 QNTLMTAVKAAERGAFEYLPKP 100
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 6-125 2.66e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 36.06  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAevFLSHPLALSGAA-LVITDIKLRGMSGLELFDKLRLlAVPPPPVLFI 84
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNG--LNGYHLAMTGDYdLIILDIMLPDVNGWDIVRMLRS-ANKGMPILLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 555205067  85 SGHADENMQRYALGLGAAAFLRKPINIDILLDHIqRELARR 125
Cdd:PRK09836  79 TALGTIEHRVKGLELGADDYLVKPFAFAELLARV-RTLLRR 118
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 6-109 3.05e-03

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 34.78  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVflshplALSGAA-----LVITDIKLRGMSGLELFDKLRllAVPPP- 79
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQE------ALALAEeelpdLILLDVMMPGMDGFEVCRRLK--EDPETr 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 555205067  80 --PVLFISG-HADENMQRyALGLGAAAFLRKPI 109
Cdd:cd17538   73 hiPVIMITAlDDREDRIR-GLEAGADDFLSKPI 104
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 78-120 3.95e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 34.43  E-value: 3.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 555205067  78 PPPVLFISGHADENMQRYALGLGAAAFLRKPINIDILLDHIQR 120
Cdd:cd17593   73 ETKVIVVSGDVQPEAKERVLELGALAFLKKPFDPEKLAQLLEE 115
PRK10766 PRK10766
two-component system response regulator TorR;
3-72 4.27e-03

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 35.40  E-value: 4.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   3 LPWRIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVfLSHPLALSGAALVITDIKLRGMSGLELFDKLR 72
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAG-MREIMQNQHVDLILLDINLPGEDGLMLTRELR 69
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 7-124 4.55e-03

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 34.38  E-value: 4.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   7 IAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLsHPLALSGAALVITDIKLRGMSGLELFDKLRlLAVPPPPVLFISG 86
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAE-AALASGPYDLVILDLGLPDGDGLDLLRRWR-RQGQSLPVLILTA 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 555205067  87 HaDENMQRYA-LGLGAAAFLRKPINIDILLDHIqRELAR 124
Cdd:cd17624   79 R-DGVDDRVAgLDAGADDYLVKPFALEELLARL-RALLR 115
PRK10693 PRK10693
two-component system response regulator RssB;
52-109 5.92e-03

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 34.97  E-value: 5.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067  52 LVITDIKLRGMSGLELFDKLRLLAVpPPPVLFISghADENMQRYA--LGLGAAAFLRKPI 109
Cdd:PRK10693  20 LIICDLAMPRMNGIEFVEHLRNRGD-QTPVLVIS--ATENMADIAkaLRLGVQDVLLKPV 76
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 6-118 7.20e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 33.91  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555205067   6 RIAIIDDERSVRSGLSNLLESEGYSTDTFDSAEVFLShPLALSGAA--LVITDIKLRGMSGLELFDKLRLLAVP--PPPV 81
Cdd:cd19933    2 KVLLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLN-LLASAEHSfqLVLLDLCMPEMDGFEVALRIRKLFGRreRPLI 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 555205067  82 LFISGHADENMQRYALGLGAAAFLRKPINIDILLDHI 118
Cdd:cd19933   81 VALTANTDDSTREKCLSLGMNGVITKPVSLHALGDEL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH