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Conserved domains on  [gi|556162003|gb|ESP50055|]
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type VI secretion protein IcmF [Escherichia coli UMEA 3148-1]

Protein Classification

type VI secretion system membrane subunit( domain architecture ID 11466348)

type VI secretion system membrane subunit such as the IcmF (intracellular multiplication protein F) family protein that exhibits ATPase activity and energizes type VI secretion; it is a conserved T6SS inner membrane protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
23-1173 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1036.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   23 RFKVSAFWLLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVMKRLQQLEKMQKQQREEA- 101
Cdd:COG3523     4 RFLTSRWVLSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAe 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  102 ----VDPLSVELNAQQRYLDRWLLRLQR----YLDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARG 170
Cdd:COG3523    84 ekaaADPSREEIEALRERFQEALATLKKsrlgQGGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  171 AEQRLYLTPHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQT 250
Cdd:COG3523   164 VGGTRNCDWWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  251 LRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLAL 330
Cdd:COG3523   244 LRQRLQELRERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERL 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  331 PDLMVAQT--HTRTSLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNN 406
Cdd:COG3523   324 LDRLQQERdpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRA 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  407 PLASWPlVDTAPYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQA 486
Cdd:COG3523   404 ALPAQS-GSGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKV 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  487 KAFMDVPPPQGEDD-FGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLV 564
Cdd:COG3523   483 DAYRALAAALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLE 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  565 KAMNAAPPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDG 642
Cdd:COG3523   563 EQLRQAPADPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGD 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  643 DAISRWTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGL 720
Cdd:COG3523   634 PSAPPLPLDEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGY 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  721 QSYFVKQRDELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVI 800
Cdd:COG3523   714 HEVFLPAIDELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLS 793
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  801 SGDQPLQRALTVLRDNTQPGVFSEKLSAKE--------REEALAEPDYQLL----------------TRLGHEFAPENST 856
Cdd:COG3523   794 SPDSPLRRLLRAVADETTLTRPSEAAAGGAaakgllaaAKARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRL 873
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  857 LAVQKDKESTMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAW 936
Cdd:COG3523   874 VEANDGGPAPLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAW 951
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  937 HVVMVEAVHYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDG 1013
Cdd:COG3523   952 SVVLGGARAHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPW 1031
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003 1014 DNNVI-IREDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrE 1091
Cdd:COG3523  1032 DGQGLgLSPAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-G 1110
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003 1092 GNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1171
Cdd:COG3523  1111 SNGARITLTPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPE 1190

                  ..
gi 556162003 1172 TL 1173
Cdd:COG3523  1191 SL 1192
 
Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
23-1173 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1036.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   23 RFKVSAFWLLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVMKRLQQLEKMQKQQREEA- 101
Cdd:COG3523     4 RFLTSRWVLSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAe 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  102 ----VDPLSVELNAQQRYLDRWLLRLQR----YLDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARG 170
Cdd:COG3523    84 ekaaADPSREEIEALRERFQEALATLKKsrlgQGGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  171 AEQRLYLTPHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQT 250
Cdd:COG3523   164 VGGTRNCDWWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  251 LRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLAL 330
Cdd:COG3523   244 LRQRLQELRERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERL 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  331 PDLMVAQT--HTRTSLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNN 406
Cdd:COG3523   324 LDRLQQERdpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRA 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  407 PLASWPlVDTAPYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQA 486
Cdd:COG3523   404 ALPAQS-GSGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKV 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  487 KAFMDVPPPQGEDD-FGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLV 564
Cdd:COG3523   483 DAYRALAAALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLE 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  565 KAMNAAPPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDG 642
Cdd:COG3523   563 EQLRQAPADPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGD 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  643 DAISRWTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGL 720
Cdd:COG3523   634 PSAPPLPLDEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGY 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  721 QSYFVKQRDELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVI 800
Cdd:COG3523   714 HEVFLPAIDELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLS 793
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  801 SGDQPLQRALTVLRDNTQPGVFSEKLSAKE--------REEALAEPDYQLL----------------TRLGHEFAPENST 856
Cdd:COG3523   794 SPDSPLRRLLRAVADETTLTRPSEAAAGGAaakgllaaAKARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRL 873
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  857 LAVQKDKESTMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAW 936
Cdd:COG3523   874 VEANDGGPAPLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAW 951
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  937 HVVMVEAVHYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDG 1013
Cdd:COG3523   952 SVVLGGARAHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPW 1031
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003 1014 DNNVI-IREDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrE 1091
Cdd:COG3523  1032 DGQGLgLSPAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-G 1110
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003 1092 GNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1171
Cdd:COG3523  1111 SNGARITLTPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPE 1190

                  ..
gi 556162003 1172 TL 1173
Cdd:COG3523  1191 SL 1192
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
31-1171 0e+00

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 892.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003    31 LLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVM---KRLQQL-EKMQKQQREEAVDPLS 106
Cdd:TIGR03348    1 LSLLGLILLCILIWWAGPLLAVGDYKPLESVWARLLIIAVLLLVWLLWLLIRQWrarRRNQQLlAALAAPTKLKADAAAE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   107 VELNAQQRYLDRWLLRLQRY-LDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FP------SDIIYAPEGARGAEQRLy 176
Cdd:TIGR03348   81 AEIRELRARFNEALALLKRSrLGGRRYLYDLPWYLVIGPPGSGKTTLLQNSglkFPlaerlgAAALRGVGGTRNCDWWF- 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   177 ltphvGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQTLRSRLQ 256
Cdd:TIGR03348  160 -----TDEAVLIDTAGRYTTQDSDPEEDAAAWLGFLGLLRKHRRRQPLNGVVVTVSLADLLTADPAERKAHARAIRQRLQ 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   257 DIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVA 336
Cdd:TIGR03348  235 ELREQLGARFPVYLVLTKADLLAGFEEFFADLDAEEREQVWGFTFPLDEADDDNAAEEFAAEFEGLLQRLNARLLERLHQ 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   337 QTHT--RTSLFSFSRQMQGSREPLVSLLEGLLDGENM--NVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLgnNPLASWP 412
Cdd:TIGR03348  315 ERDAarRAAIFRFPAQLAALKDRLVQFLEEAFAANRYeeAPLLRGVYFTSATQEGTPIDRLLGALARGFGL--SPGPPAA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   413 LVDTA-PYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMD 491
Cdd:TIGR03348  393 ARGEGrSYFLKDLFKEVIFPEAGLAGLNRRAERRRRWLRRGAYAAAALAALGLLGLWSLSYLANRDYLDEVRTQLEAYRA 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   492 VPPPQG-EDDFGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA 569
Cdd:TIGR03348  473 LAQAIPaAPADVLALLPALDALRDAPLGFGNYDEAPPLlARFGLYQGDKLGEAVRETYLRALQAVLLPRLMQRLEAQLQA 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   570 APPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHG--QRDIQAQLMSHLDYALahtdwhaerqAGDGDAISR 647
Cdd:TIGR03348  553 QEQDPEELYETLKVYLMLGDPSRRDADFVKAWFASRWEQQYPGeyQRELREALLGHLRALL----------SLDQDAVPA 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   648 WTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFV 725
Cdd:TIGR03348  623 FPLDDALVEQARAELRAIPLAQRVYQRLKLQPLDAALPDLSLADALGPQADLVFERRSGKPLslGIPGLYTRAGYHDVFL 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   726 KQRDELVELTAMDSWVLN-LTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQ 804
Cdd:TIGR03348  703 PQIANLVERALEDAWVLGgASGNSQLSEADRQALAREVRKLYFADYINQWDALLNDLRLKPFESLAQAAALARALASPDS 782
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   805 PLQRALTVLRDNT----------------QPGVFSEKLSAKEREEALAEPDYQLLT---RLGHEFAPENSTLAVQKDKES 865
Cdd:TIGR03348  783 PLARLLRAVARETrltpvdgapadggsnaAAKKLSGLASALGAQLLPAAPGAAALPepgAVERHFEPLRRLLAPNGGPGA 862
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   866 TMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrldQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAVH 945
Cdd:TIGR03348  863 ALDALLAALNELYQQLQALAASPNPGQAALKARM----SGLADALSALRQAAARLPEPLRGWLGSLAADTWKLVLQAARS 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   946 YMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IRE 1021
Cdd:TIGR03348  939 HLNARWQSEVYSFCQQAIAGRYPFSPNSSKDVPLADFERFFGPGGLLDSFFQQNLAPFVDtsaNPWRWKGGDGGSLgISP 1018
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  1022 DIIAQLETAQKIRDIFF-SKQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTLI 1100
Cdd:TIGR03348 1019 SVLAQFQRAARIRDAFFrSGGGEPAVSFTLKPISLDPNIRRFVLEVDGQTLRYAHGPTRPVSLTWPGPN-DGGLARLTLK 1097
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556162003  1101 GTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGN-FTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1171
Cdd:TIGR03348 1098 PADGGSPRTLTFSGPWALFRLLDAGRLTRTGSRDrLDLRFDVGGGAVRYELRAGSADNPFTSGLLSGFRCPG 1169
IcmF-related pfam06761
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
506-818 1.58e-71

Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.


Pssm-ID: 429106 [Multi-domain]  Cd Length: 305  Bit Score: 241.09  E-value: 1.58e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   506 LPLLNPVRDATLA--YGDWGDRSRLADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA-APPESEEKLAVLR 582
Cdd:pfam06761    1 LPALDALRDLPEGllDYYQEGPPLSYRFGLYQGDKLGAAARAAYRRALRQLLLPRLAQRLEAQLRAlAGPDPEALYEALK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   583 VMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQRDIQ--AQLMSHLDYALAHtdwhAERQAGDGDAISRwtpydkpvvsAQK 660
Cdd:pfam06761   81 AYLMLGDPERRDAAFLAAWLTRDWERALPGQATGQqrEALLAHLDALLAD----PPAIPPDAALVAQ----------ARA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   661 ELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVKQRDELVELTAMD 738
Cdd:pfam06761  147 TLARVPLAERVYQRLKRQALASALPDFTLADAVGPDAALVFTRSSGKPLseGVPGLFTRAGYHGYFLPALDELAELLLEE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   739 SWVLNLTRSVKYsDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQRALTVLRDNTQ 818
Cdd:pfam06761  227 DWVLGDLAASAL-EADPEQLADDLRELYFTDYAAAWQAFLNDLRLVPFASLAQAIDVLRLLADPDSPLLRLLQAVADETT 305
 
Name Accession Description Interval E-value
IcmF COG3523
Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and ...
23-1173 0e+00

Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442745 [Multi-domain]  Cd Length: 1192  Bit Score: 1036.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   23 RFKVSAFWLLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVMKRLQQLEKMQKQQREEA- 101
Cdd:COG3523     4 RFLTSRWVLSLLGLLALALLIWFGGPLLAIGDYRPLESVLVRLLAIAVILLLWLLVWLVRRWRARRANRALEDALAEQAe 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  102 ----VDPLSVELNAQQRYLDRWLLRLQR----YLDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FPSDIIYAPEGARG 170
Cdd:COG3523    84 ekaaADPSREEIEALRERFQEALATLKKsrlgQGGGRRALYELPWYLIIGPPGAGKTTALVNSglkFPLADKFGKAAIRG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  171 AEQRLYLTPHVGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQT 250
Cdd:COG3523   164 VGGTRNCDWWFTDEAVLIDTAGRYTTQDSDAEVDRAEWLGFLDLLKKHRPRQPINGVIVAISLADLLTQSPEEREQHAKA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  251 LRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLAL 330
Cdd:COG3523   244 LRQRLQELRERLGIRFPVYVLFTKADLLAGFSEFFADLDKEEREQVWGFTFPYDEKQEFDLLAEFDAEFDELLERLNERL 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  331 PDLMVAQT--HTRTSLFSFSRQMQGSREPLVSLLEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNN 406
Cdd:COG3523   324 LDRLQQERdpERRALIFGFPQQFAALKEALAEFLEELFEPNRyqTPPLLRGVYFTSGTQEGTPIDRVMGALARNFGLSRA 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  407 PLASWPlVDTAPYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQA 486
Cdd:COG3523   404 ALPAQS-GSGRSYFLKDLFSKVIFPEAGLAGRNRRWERRRRWLRRAAYAAAALALLGLLGGWTWSYLNNRRLLAEVEAKV 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  487 KAFMDVPPPQGEDD-FGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLV 564
Cdd:COG3523   483 DAYRALAAALLVADtDLAALLPALNALRDLPAGYGYRRDDPPLsAGLGLYQGDKLGPAARAAYLRALEQLLLPRLALRLE 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  565 KAMNAAPPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQ--RDIQAQLMSHLDYALAHtdwhaerqaGDG 642
Cdd:COG3523   563 EQLRQAPADPEELYEALKAYLMLGDPEHRDADFLKAWMARDWRELLPGNtrAELRAALERHLDALLDL---------GGD 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  643 DAISRWTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDN--KLVVPQFLTRYGL 720
Cdd:COG3523   634 PSAPPLPLDEALVAQARAELRRVPLAQRVYARLKARALATRLPDFTLADAVGPQAALVFTRSSGKplTLGIPGLFTREGY 713
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  721 QSYFVKQRDELVELTAMDSWVLNLTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVI 800
Cdd:COG3523   714 HEVFLPAIDELAEELARDDWVLGLSAEDDLSEADREQLQREVRQLYLADYIAEWRAFLGDLRLAPFTSLAQAIAALRVLS 793
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  801 SGDQPLQRALTVLRDNTQPGVFSEKLSAKE--------REEALAEPDYQLL----------------TRLGHEFAPENST 856
Cdd:COG3523   794 SPDSPLRRLLRAVADETTLTRPSEAAAGGAaakgllaaAKARLLSARGRLGrllgadaaaaaaqvpgQPVDRHFAPLHRL 873
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  857 LAVQKDKESTMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrLDQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAW 936
Cdd:COG3523   874 VEANDGGPAPLDDYLQALNELYTYLTAIANAPDPGKAALKLAK--ASGGGSDLISALKAEAGRLPEPLRRWLGSLADQAW 951
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  937 HVVMVEAVHYMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDG 1013
Cdd:COG3523   952 SVVLGGARAHLNRRWRAEVYPFCRQAIAGRYPFAPRSSRDVALADFARFFGPGGILDSFFQQNLKPFVDtsgRPWRFRPW 1031
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003 1014 DNNVI-IREDIIAQLETAQKIRDIFFS-KQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrE 1091
Cdd:COG3523  1032 DGQGLgLSPAVLAQFQRAAAIRDAFFAgGGAEPSVRFQIKPVSLDPGISRFTLEIDGQLLRYRHGPQRPVSVVWPGPG-G 1110
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003 1092 GNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGNFTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1171
Cdd:COG3523  1111 SNGARITLTPLDGTSPSSLSYEGPWALFRLLDKAQLTTVSPDSFTVTFTVDGRSVTYELRADSVNNPFALPLLRGFRCPE 1190

                  ..
gi 556162003 1172 TL 1173
Cdd:COG3523  1191 SL 1192
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
31-1171 0e+00

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 892.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003    31 LLILAWIFLLVWIWWKGPTWTLYEEQWLKPLANRWLATAAWGIIALMWLTVRVM---KRLQQL-EKMQKQQREEAVDPLS 106
Cdd:TIGR03348    1 LSLLGLILLCILIWWAGPLLAVGDYKPLESVWARLLIIAVLLLVWLLWLLIRQWrarRRNQQLlAALAAPTKLKADAAAE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   107 VELNAQQRYLDRWLLRLQRY-LDNRRFLWQLPWYMVIGPAGSGKTTLLREG---FP------SDIIYAPEGARGAEQRLy 176
Cdd:TIGR03348   81 AEIRELRARFNEALALLKRSrLGGRRYLYDLPWYLVIGPPGSGKTTLLQNSglkFPlaerlgAAALRGVGGTRNCDWWF- 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   177 ltphvGKQAVIFDIDGTLCAPADADILHRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQTLRSRLQ 256
Cdd:TIGR03348  160 -----TDEAVLIDTAGRYTTQDSDPEEDAAAWLGFLGLLRKHRRRQPLNGVVVTVSLADLLTADPAERKAHARAIRQRLQ 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   257 DIRQHLHCQLPVYVVLTRLDLLQGFAALFQSLNRQDRDAILGVTFTRRAHENDDWRTELNAFWQTWVDRMNLALPDLMVA 336
Cdd:TIGR03348  235 ELREQLGARFPVYLVLTKADLLAGFEEFFADLDAEEREQVWGFTFPLDEADDDNAAEEFAAEFEGLLQRLNARLLERLHQ 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   337 QTHT--RTSLFSFSRQMQGSREPLVSLLEGLLDGENM--NVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLgnNPLASWP 412
Cdd:TIGR03348  315 ERDAarRAAIFRFPAQLAALKDRLVQFLEEAFAANRYeeAPLLRGVYFTSATQEGTPIDRLLGALARGFGL--SPGPPAA 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   413 LVDTA-PYFTRSLFPQALLAEPNLATESRAWLIRSRRRLTVFSATGGVAALLLITGWHHYYNGNYQSGITVLKQAKAFMD 491
Cdd:TIGR03348  393 ARGEGrSYFLKDLFKEVIFPEAGLAGLNRRAERRRRWLRRGAYAAAALAALGLLGLWSLSYLANRDYLDEVRTQLEAYRA 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   492 VPPPQG-EDDFGNLQLPLLNPVRDATLAYGDWGDRSRL-ADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA 569
Cdd:TIGR03348  473 LAQAIPaAPADVLALLPALDALRDAPLGFGNYDEAPPLlARFGLYQGDKLGEAVRETYLRALQAVLLPRLMQRLEAQLQA 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   570 APPESEEKLAVLRVMRMLEDKSGRNNEVVKQYMAKRWSEKFHG--QRDIQAQLMSHLDYALahtdwhaerqAGDGDAISR 647
Cdd:TIGR03348  553 QEQDPEELYETLKVYLMLGDPSRRDADFVKAWFASRWEQQYPGeyQRELREALLGHLRALL----------SLDQDAVPA 622
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   648 WTPYDKPVVSAQKELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFV 725
Cdd:TIGR03348  623 FPLDDALVEQARAELRAIPLAQRVYQRLKLQPLDAALPDLSLADALGPQADLVFERRSGKPLslGIPGLYTRAGYHDVFL 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   726 KQRDELVELTAMDSWVLN-LTRSVKYSDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQ 804
Cdd:TIGR03348  703 PQIANLVERALEDAWVLGgASGNSQLSEADRQALAREVRKLYFADYINQWDALLNDLRLKPFESLAQAAALARALASPDS 782
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   805 PLQRALTVLRDNT----------------QPGVFSEKLSAKEREEALAEPDYQLLT---RLGHEFAPENSTLAVQKDKES 865
Cdd:TIGR03348  783 PLARLLRAVARETrltpvdgapadggsnaAAKKLSGLASALGAQLLPAAPGAAALPepgAVERHFEPLRRLLAPNGGPGA 862
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   866 TMQAVYQQLTELHRYLLAIQNAPVPGKSALKAVQlrldQNSSDPIFATRQMAKTLPAPLNRWVGRLTDQAWHVVMVEAVH 945
Cdd:TIGR03348  863 ALDALLAALNELYQQLQALAASPNPGQAALKARM----SGLADALSALRQAAARLPEPLRGWLGSLAADTWKLVLQAARS 938
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   946 YMEVDWRDSVVKPFNEQLANNYPFNPRSAQDASLDAFERFFKPDGILDTFYQQNLKLFID---NDLSLEDGDNNVI-IRE 1021
Cdd:TIGR03348  939 HLNARWQSEVYSFCQQAIAGRYPFSPNSSKDVPLADFERFFGPGGLLDSFFQQNLAPFVDtsaNPWRWKGGDGGSLgISP 1018
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  1022 DIIAQLETAQKIRDIFF-SKQNGLGTSFAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNMrEGNESKLTLI 1100
Cdd:TIGR03348 1019 SVLAQFQRAARIRDAFFrSGGGEPAVSFTLKPISLDPNIRRFVLEVDGQTLRYAHGPTRPVSLTWPGPN-DGGLARLTLK 1097
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556162003  1101 GTSGNAPRSISFSGPWAQFRLFGAGQLTGVQDGN-FTVRFSVDGGAMTYRVHTDTEDNPFSGGLFSQFGLSD 1171
Cdd:TIGR03348 1098 PADGGSPRTLTFSGPWALFRLLDAGRLTRTGSRDrLDLRFDVGGGAVRYELRAGSADNPFTSGLLSGFRCPG 1169
IcmF-related pfam06761
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
506-818 1.58e-71

Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.


Pssm-ID: 429106 [Multi-domain]  Cd Length: 305  Bit Score: 241.09  E-value: 1.58e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   506 LPLLNPVRDATLA--YGDWGDRSRLADMGLYQGRRIGPYVEQTYLQLLEQRYLPSLFNGLVKAMNA-APPESEEKLAVLR 582
Cdd:pfam06761    1 LPALDALRDLPEGllDYYQEGPPLSYRFGLYQGDKLGAAARAAYRRALRQLLLPRLAQRLEAQLRAlAGPDPEALYEALK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   583 VMRMLEDKSGRNNEVVKQYMAKRWSEKFHGQRDIQ--AQLMSHLDYALAHtdwhAERQAGDGDAISRwtpydkpvvsAQK 660
Cdd:pfam06761   81 AYLMLGDPERRDAAFLAAWLTRDWERALPGQATGQqrEALLAHLDALLAD----PPAIPPDAALVAQ----------ARA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   661 ELSKLPVYQRVYQSLKTRALGVLPADLNLRDQVGPTFDQVFTSADDNKL--VVPQFLTRYGLQSYFVKQRDELVELTAMD 738
Cdd:pfam06761  147 TLARVPLAERVYQRLKRQALASALPDFTLADAVGPDAALVFTRSSGKPLseGVPGLFTRAGYHGYFLPALDELAELLLEE 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   739 SWVLNLTRSVKYsDADRAEIQRQLTEQYISDYTATWRAGMDNLNIRNFESIGQLTGALEQVISGDQPLQRALTVLRDNTQ 818
Cdd:pfam06761  227 DWVLGDLAASAL-EADPEQLADDLRELYFTDYAAAWQAFLNDLRLVPFASLAQAIDVLRLLADPDSPLLRLLQAVADETT 305
IcmF-related_N pfam14331
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
204-457 7.48e-59

IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.


Pssm-ID: 433873 [Multi-domain]  Cd Length: 258  Bit Score: 203.23  E-value: 7.48e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   204 HRRLWEHALGWLKEKRARQPLNGIILTLDLPDLLTADKRRREHLLQTLRSRLQDIRQHLHCQLPVYVVLTRLDLLQGFAA 283
Cdd:pfam14331    3 DAAEWLGFLDLLKKHRPRQPINGVLVTVSLADLLSASEEEREAHARALRARLQELRETLGVRFPVYVVLTKADLLAGFDE 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   284 LFQSLNRQDRDAILGVTFTRRAHENDDWRtELNAFWQTWVDRMNLALPDLMVAQ--THTRTSLFSFSRQMQGSREPLVSL 361
Cdd:pfam14331   83 FFADLDREEREQVWGFTFPYDADDEPDAV-LFDQEFDELLERLNARLLDRLQEErdAERRAAIFAFPRQFAALKPRLREF 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003   362 LEGLLDGEN--MNVMLRGVYLTSSLQRGQMDDIFTQSAARQYRLGNNPLASWPlVDTAPYFTRSLFPQALLAEPNLATES 439
Cdd:pfam14331  162 LEELFAPNRyqEAPLLRGVYFTSATQEGTPIDRLAGALARRFGLEAAALPATS-GAGRSYFLHDLFRDVIFPEAGLAGPN 240
                          250
                   ....*....|....*...
gi 556162003   440 RAWLIRSRRRLTVFSATG 457
Cdd:pfam14331  241 RRWERRRRLLRRAGYAAA 258
IcmF_C pfam06744
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region ...
1048-1154 2.34e-26

Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganization that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear.


Pssm-ID: 429094 [Multi-domain]  Cd Length: 106  Bit Score: 104.34  E-value: 2.34e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556162003  1048 FAVETVSLSGNKRRSVLNLDGQLVDYSQGRNYTAHLVWPNNmREGNESKLTLIGTSGNAPRSISFSGPWAQFRLFGAGQL 1127
Cdd:pfam06744    1 FELRPLPLDPGVTRFVLEIDGQTLRYRHGPSQWTPFSWPGP-RGSPGARLTLTDDDGGTVSTLSYEGPWALFRLLDKAQV 79
                           90       100
                   ....*....|....*....|....*..
gi 556162003  1128 TGVQDGNFTVRFSVDGGAMTYRVHTDT 1154
Cdd:pfam06744   80 TRTDSDRFRLTFDVDGRKARYELRADS 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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