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Conserved domains on  [gi|576417501|gb|EUA11262|]
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phosphate ABC transporter, permease protein PstA [Mycobacterium kansasii 732]

Protein Classification

PstA family ABC transporter permease( domain architecture ID 11426443)

PstA family ABC transporter permease is the transmembrane subunit (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters; similar to phosphate transport system permease protein PstA

Gene Ontology:  GO:0140359|GO:0042626|GO:0043190|GO:0016020
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PstA COG0581
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 39-293 2.17e-89

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440346 [Multi-domain]  Cd Length: 259  Bit Score: 267.29  E-value: 2.17e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  39 IALVPLVWLLWVVIERGWYAIiRLDWWTHSLRgvlPEEFAGGVYHALYGTLVQAGVAAVLAVPLGLMTAIYLVEYGT-GR 117
Cdd:COG0581    1 LALLPLVWILGTVLVKGLPAL-SWEFLTSSPS---PGPEGGGILPAIVGTLLLVLLATLIAVPLGVLAAIYLAEYARgGR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 118 MARVTTFMVDVLAGVPSIVAALFIFSLWIATLGFQQSAFAVSLALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKW 197
Cdd:COG0581   77 LARLIRFAIDVLAGVPSIVYGLFGYALFVLTLGLGFSLLAGALALALLMLPVVIRTTEEALRLVPNSLREASYALGATKW 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 198 KTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFnGNMASLPLLIYTELTNPEHAGFLRVWGAALT 277
Cdd:COG0581  157 QTIRKVVLPAALPGILTGVILAIARAAGETAPLLFTAGVSPFLPLSLF-DPFATLPVHIYNLASSPYPAAQELAWAAALV 235

                        250
                 ....*....|....*.
gi 576417501 278 LIILVAVINVVAAGIR 293
Cdd:COG0581  236 LLLLVLLLNLLARLLR 251
 
Name Accession Description Interval E-value
PstA COG0581
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 39-293 2.17e-89

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440346 [Multi-domain]  Cd Length: 259  Bit Score: 267.29  E-value: 2.17e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  39 IALVPLVWLLWVVIERGWYAIiRLDWWTHSLRgvlPEEFAGGVYHALYGTLVQAGVAAVLAVPLGLMTAIYLVEYGT-GR 117
Cdd:COG0581    1 LALLPLVWILGTVLVKGLPAL-SWEFLTSSPS---PGPEGGGILPAIVGTLLLVLLATLIAVPLGVLAAIYLAEYARgGR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 118 MARVTTFMVDVLAGVPSIVAALFIFSLWIATLGFQQSAFAVSLALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKW 197
Cdd:COG0581   77 LARLIRFAIDVLAGVPSIVYGLFGYALFVLTLGLGFSLLAGALALALLMLPVVIRTTEEALRLVPNSLREASYALGATKW 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 198 KTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFnGNMASLPLLIYTELTNPEHAGFLRVWGAALT 277
Cdd:COG0581  157 QTIRKVVLPAALPGILTGVILAIARAAGETAPLLFTAGVSPFLPLSLF-DPFATLPVHIYNLASSPYPAAQELAWAAALV 235

                        250
                 ....*....|....*.
gi 576417501 278 LIILVAVINVVAAGIR 293
Cdd:COG0581  236 LLLLVLLLNLLARLLR 251
3a0107s02c TIGR00974
phosphate ABC transporter, permease protein PstA; This model describes PtsA, one of a pair of ...
 26-289 7.42e-68

phosphate ABC transporter, permease protein PstA; This model describes PtsA, one of a pair of permease proteins in the ABC (high affinity) phosphate transporter. In a number of species, this permease is fused with the PtsC protein (TIGR02138). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions]


Pssm-ID: 273373  Cd Length: 271  Bit Score: 212.87  E-value: 7.42e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   26 NSLATVVFFSSFAIALVPLVWLLWVVIERGwYAIIRLDWWTHSLRGVLPEefaGGVYHALYGTLVQAGVAAVLAVPLGLM 105
Cdd:TIGR00974   1 DKIFTFISLLSALLALLPLIWILWYILIKG-LPALNLEFFTKSPTPTGAE---GGIGPAIVGTLLLTLLAIVIAVPLGIG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  106 TAIYLVEYG-TGRMARVTTFMVDVLAGVPSIVAALFIFSLWIAT-LGFQQSAFAVSLALVLLMLPVVVRSTEEMLRLVPD 183
Cdd:TIGR00974  77 AAIYLAEYAnGSRFTKIIRFAVDILAGVPSIVVGLFGYGFFVLTyLGGGFSLLAGALALALLILPVIIRTTEEALKAVPK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  184 ELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFnGNMASLPLLIY---TEL 260
Cdd:TIGR00974 157 DLREASLALGATKWQTIFKVVLPAALPGILTGIILSIARAAGETAPLLFTAGGSAFTPPNLF-DPFATLPVLIYnlaSEG 235

                         250       260
                  ....*....|....*....|....*....
gi 576417501  261 TNPEHAgfLRVWGAALTLIILVAVINVVA 289
Cdd:TIGR00974 236 PYVEAQ--QLAWAAALVLIVLVLLLNLIA 262
pstA PRK11268
phosphate ABC transporter permease PstA;
2-289 4.62e-47

phosphate ABC transporter permease PstA;


Pssm-ID: 183065 [Multi-domain]  Cd Length: 295  Bit Score: 160.23  E-value: 4.62e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   2 SIDALDRPVKAVVFRPLSLARRIKNSLATVVFFSSFAIALVPLVWLLWVVIERGwyaIIRLDWWTHSLRGVLPEEFAGGV 81
Cdd:PRK11268   3 TVEMQNTAALAESRRKMQARRRLKNRIALTLSMATMAFGLFWLIWILMSTITLG---IDGMSLALFTEMTPPPNTAGGGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  82 YHALYGTLVQAGVAAVLAVPLGLMTAIYLVEYG-TGRMARVTTFMVDVLAGVPSIVAALFIFSLWIATLGfQQSAFAVSL 160
Cdd:PRK11268  80 ANAIAGSGLLILWATVVGTPLGIMAGIYLAEYGrKSWLAEVIRFINDILLSAPSIVVGLFVYTIVVAQME-HFSGWAGVI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 161 ALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSI 240
Cdd:PRK11268 159 ALALLQIPIVIRTTENMLKLVPDSLREAAYALGTPKWKMISAITLKASVSGIMTGVLLAIARIAGETAPLLFTALSNQFW 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 576417501 241 NLDIfNGNMASLPLLIYTELTNPEHAGFLRVWGAALTLIILVAVINVVA 289
Cdd:PRK11268 239 STDM-MQPIANLPVTIFKFAMSPFAEWQQLAWAGVLLITLCVLLLNILA 286
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 85-240 2.05e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.69  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  85 LYGTLVQAGVAAVLAVPLGLMTAIYLVEYGtGRMARVTTFMVDVLAGVPSIVAALFIFSLWIATLGF---QQSAFAVSLA 161
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKR-GKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWgilPGLGLPALIL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576417501 162 LVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSI 240
Cdd:cd06261   80 ALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG 158
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 99-237 6.12e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.92  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   99 AVPLGLMTAIYLVeygtGRMARVTTFMVDVLAGVPSIVAALFIFSLWIATLgFQQSAFAVSLALVLLMLPVVVRSTEEML 178
Cdd:pfam00528   1 GIPLGIIAALRRG----RRLDRLLRPLIDLLQALPSFVLAILLVVIAILSI-LGHGILPAIILALLGWAGYARLIRRAAL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 576417501  179 RLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYS 237
Cdd:pfam00528  76 RSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP 134
 
Name Accession Description Interval E-value
PstA COG0581
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 39-293 2.17e-89

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440346 [Multi-domain]  Cd Length: 259  Bit Score: 267.29  E-value: 2.17e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  39 IALVPLVWLLWVVIERGWYAIiRLDWWTHSLRgvlPEEFAGGVYHALYGTLVQAGVAAVLAVPLGLMTAIYLVEYGT-GR 117
Cdd:COG0581    1 LALLPLVWILGTVLVKGLPAL-SWEFLTSSPS---PGPEGGGILPAIVGTLLLVLLATLIAVPLGVLAAIYLAEYARgGR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 118 MARVTTFMVDVLAGVPSIVAALFIFSLWIATLGFQQSAFAVSLALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKW 197
Cdd:COG0581   77 LARLIRFAIDVLAGVPSIVYGLFGYALFVLTLGLGFSLLAGALALALLMLPVVIRTTEEALRLVPNSLREASYALGATKW 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 198 KTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFnGNMASLPLLIYTELTNPEHAGFLRVWGAALT 277
Cdd:COG0581  157 QTIRKVVLPAALPGILTGVILAIARAAGETAPLLFTAGVSPFLPLSLF-DPFATLPVHIYNLASSPYPAAQELAWAAALV 235

                        250
                 ....*....|....*.
gi 576417501 278 LIILVAVINVVAAGIR 293
Cdd:COG0581  236 LLLLVLLLNLLARLLR 251
3a0107s02c TIGR00974
phosphate ABC transporter, permease protein PstA; This model describes PtsA, one of a pair of ...
 26-289 7.42e-68

phosphate ABC transporter, permease protein PstA; This model describes PtsA, one of a pair of permease proteins in the ABC (high affinity) phosphate transporter. In a number of species, this permease is fused with the PtsC protein (TIGR02138). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions]


Pssm-ID: 273373  Cd Length: 271  Bit Score: 212.87  E-value: 7.42e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   26 NSLATVVFFSSFAIALVPLVWLLWVVIERGwYAIIRLDWWTHSLRGVLPEefaGGVYHALYGTLVQAGVAAVLAVPLGLM 105
Cdd:TIGR00974   1 DKIFTFISLLSALLALLPLIWILWYILIKG-LPALNLEFFTKSPTPTGAE---GGIGPAIVGTLLLTLLAIVIAVPLGIG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  106 TAIYLVEYG-TGRMARVTTFMVDVLAGVPSIVAALFIFSLWIAT-LGFQQSAFAVSLALVLLMLPVVVRSTEEMLRLVPD 183
Cdd:TIGR00974  77 AAIYLAEYAnGSRFTKIIRFAVDILAGVPSIVVGLFGYGFFVLTyLGGGFSLLAGALALALLILPVIIRTTEEALKAVPK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  184 ELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFnGNMASLPLLIY---TEL 260
Cdd:TIGR00974 157 DLREASLALGATKWQTIFKVVLPAALPGILTGIILSIARAAGETAPLLFTAGGSAFTPPNLF-DPFATLPVLIYnlaSEG 235

                         250       260
                  ....*....|....*....|....*....
gi 576417501  261 TNPEHAgfLRVWGAALTLIILVAVINVVA 289
Cdd:TIGR00974 236 PYVEAQ--QLAWAAALVLIVLVLLLNLIA 262
pstA PRK11268
phosphate ABC transporter permease PstA;
2-289 4.62e-47

phosphate ABC transporter permease PstA;


Pssm-ID: 183065 [Multi-domain]  Cd Length: 295  Bit Score: 160.23  E-value: 4.62e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   2 SIDALDRPVKAVVFRPLSLARRIKNSLATVVFFSSFAIALVPLVWLLWVVIERGwyaIIRLDWWTHSLRGVLPEEFAGGV 81
Cdd:PRK11268   3 TVEMQNTAALAESRRKMQARRRLKNRIALTLSMATMAFGLFWLIWILMSTITLG---IDGMSLALFTEMTPPPNTAGGGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  82 YHALYGTLVQAGVAAVLAVPLGLMTAIYLVEYG-TGRMARVTTFMVDVLAGVPSIVAALFIFSLWIATLGfQQSAFAVSL 160
Cdd:PRK11268  80 ANAIAGSGLLILWATVVGTPLGIMAGIYLAEYGrKSWLAEVIRFINDILLSAPSIVVGLFVYTIVVAQME-HFSGWAGVI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 161 ALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSI 240
Cdd:PRK11268 159 ALALLQIPIVIRTTENMLKLVPDSLREAAYALGTPKWKMISAITLKASVSGIMTGVLLAIARIAGETAPLLFTALSNQFW 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 576417501 241 NLDIfNGNMASLPLLIYTELTNPEHAGFLRVWGAALTLIILVAVINVVA 289
Cdd:PRK11268 239 STDM-MQPIANLPVTIFKFAMSPFAEWQQLAWAGVLLITLCVLLLNILA 286
PstC COG0573
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 16-289 2.68e-39

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440338 [Multi-domain]  Cd Length: 303  Bit Score: 140.23  E-value: 2.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  16 RPLSLARRIKNSLATVVFFSSFAIALVPLVWLLWVVIERGWYAIIRLDWW---THSLRGVLPEEFAGGVYHALYGTLVQA 92
Cdd:COG0573    7 RPRRRRRRLGDRLFRGLLLLAALLSILILLLIVLFLLIESLPAFQEVGLLeflTGTEWNPVSSNGEFGILPLIVGTLLVS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  93 GVAAVLAVPLGLMTAIYLVEYGTGRMARVTTFMVDVLAGVPSIV---AALFIFSLWIATL----GFQQSAFAVSLALVLL 165
Cdd:COG0573   87 LIALLIAVPLGLGIAIFLSEYAPPRLRRILKPAIELLAGIPSVVygfWGLFVLVPLLRDLfpwpPSGFSLLTAGIVLAIM 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 166 MLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIF 245
Cdd:COG0573  167 ILPTITSLSRDALRAVPRSLREAALALGATRWETIRKVVLPAARSGIIAAVILGLGRALGETMAVLMVAGNAPQIPFSLF 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 576417501 246 NGnMASLPLLIYTELTNPEHAGFLR--VWGAALTLIILVAVINVVA 289
Cdd:COG0573  247 DP-GRTLTALIALEFGEAPFGSLHYsaLFALGLVLFVITLLVNLLA 291
phosphate_pstC TIGR02138
phosphate ABC transporter, permease protein PstC; The typical operon for the high affinity ...
 32-292 2.59e-28

phosphate ABC transporter, permease protein PstC; The typical operon for the high affinity inorganic phosphate ABC transporter encodes an ATP-binding protein, a phosphate-binding protein, and two permease proteins. This family consists of one of the two permease proteins, PstC, which is homologous to PstA (TIGR00974). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions]


Pssm-ID: 273992 [Multi-domain]  Cd Length: 295  Bit Score: 110.82  E-value: 2.59e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   32 VFFSSFAIALVPLVWLLWVVIERGW-----YAIIRLDWWTHSLRGVLPEEFAGGVYHALYGTLVQAGVAAVLAVPLGLMT 106
Cdd:TIGR02138   7 LLLFSAVIIVLVLLLIVLFLLYEAIpafekNGILNFLTGTVWDPGSGPVQEQYGALPLIVGTLITSLIALLIAVPVGIGI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  107 AIYLVEYGTGRMARVTTFMVDVLAGVPSIVAALF-----------IFSLWIAT-----LGFQQSAFAVSLALVLLMLPVV 170
Cdd:TIGR02138  87 AIFLSEIAPKRVRSVLKPVVELLAGIPSVVYGFWglfvlvpflkpHFQPFLGSnlgliPLFGGPILTAGIVLAIMILPTI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  171 VRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFNGNMA 250
Cdd:TIGR02138 167 ASISRDALRAVPRSYKEASYALGATKWETIRRVILPAARSGIVGAVVLGLGRALGETMAVTMVIGNVFPISPLSLFDPGT 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 576417501  251 SLPLLIYTELTN--PEHAGFLRVWGAALTLIILVAVINVVAAGI 292
Cdd:TIGR02138 247 TITSLIANQFGEasGGSVHTSALFALGLVLFVITLLVNILARYI 290
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
11-298 2.10e-14

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 73.27  E-value: 2.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  11 KAVVFRPLSLARRIKNSLATVVFFSSFAIaLVPLVWLLWVVIERGWYAIIRLDWWTHSLrgvlpeeFAGGVYHALYGTLV 90
Cdd:COG1178  274 RARRPRRVKLGRWRWLALALCLLLVLLGL-LLPLLALLLWSLTKALDDNLTLDNYRFVL-------LDPSLLRALLNSLL 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  91 QAGVAAVLAVPLGLMTAiYLVEYGTGRMARVTTFMVDVLAGVPSIV--AALFIFSLWIATLGFQQSAFAVSLALVLLMLP 168
Cdd:COG1178  346 LALLAALLAVLLALLLA-YLVRRRRGRLARLLDRLAMLPYAVPGIVlgLGLLLLFNRPLPLLLYGTLAILVLAYVVRFLP 424

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 169 VVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVgysrsinldifNGN 248
Cdd:COG1178  425 FALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLR-----------PPG 493

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 576417501 249 MASLPLLIYTELTNPEHAGflrvwGAALTLIILVAVINVVAAGIRFVSTR 298
Cdd:COG1178  494 FETLAVLIYQLASSGRYGE-----AAALALLLVLVSLLPVLLLERLLGRR 538
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 85-240 2.05e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.69  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  85 LYGTLVQAGVAAVLAVPLGLMTAIYLVEYGtGRMARVTTFMVDVLAGVPSIVAALFIFSLWIATLGF---QQSAFAVSLA 161
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKR-GKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWgilPGLGLPALIL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576417501 162 LVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSI 240
Cdd:cd06261   80 ALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG 158
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 37-260 2.76e-10

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 59.76  E-value: 2.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  37 FAIALVPLVWLLWVVIERGWYAIIRLdwwthslrgVLPEEfaggVYHALYGTLVQAGVAAVLAVPLGLMTAIYLVEYgTG 116
Cdd:COG0555   21 SLIVLLPLAALVLKAAGLGWAEFWAV---------LTSPR----VLAALKLSLGTALIAALINLVFGLPLAWVLVRY-RF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 117 RMARVTTFMVDVLAGVPSIVA-----ALF----IFSLWIATLGFQ--QSAFAVSLALVLLMLPVVVRSTEEMLRLVPDEL 185
Cdd:COG0555   87 PGKRLVDALVDLPFALPTAVAgiallLLFgpngWLGQLLAPLGIKvaFTPLGIVLAQTFVSLPFVVRTVQPVLEELDPEL 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576417501 186 REASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRsinldifnGNMASLPLLIYTEL 260
Cdd:COG0555  167 EEAAATLGASRWQTFRRVILPLLLPALLTGFALAFARALGEFGAVIFIAGNLP--------MKTEILPLLIYLKL 233
pstC PRK11275
phosphate ABC transporter permease PstC;
85-235 9.11e-10

phosphate ABC transporter permease PstC;


Pssm-ID: 183070  Cd Length: 319  Bit Score: 58.94  E-value: 9.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  85 LYGTLVQAGVAAVLAVPLGLMTAIYLVEYGTGRMARVTTFMVDVLAGVPSIVAA---LFIF-----------------SL 144
Cdd:PRK11275  75 IYGTLVTSFIALLIAVPVSFGIALFLTELAPGWLKRPLGIAIELLAAIPSIVYGmwgLFVFaplfatyfqepvgnvlsNI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 145 WIATLGFQQSAF-----AVSLALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLA 219
Cdd:PRK11275 155 PIVGALFSGPAFgigilAAGVILAIMIIPYIAAVMRDVFEQTPVMMKESAYGIGCTTWEVIWRIVLPFTKNGVIGGVMLG 234

                        170
                 ....*....|....*.
gi 576417501 220 LARIIGETAPVLVLVG 235
Cdd:PRK11275 235 LGRALGETMAVTFIIG 250
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 22-300 8.11e-09

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 55.50  E-value: 8.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  22 RRIKNSLATVVFFSSFAIALVPLVWLLWVVIERGWYAIIR-----LDWWTHSLRgvlpeefAGGVYHALYGTLVQAGVAA 96
Cdd:COG1177    2 SRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTFPpegftLRWYAELFS-------DPRLLDALLNSLLIALLST 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  97 VLAVPLGLMTAIYLVEYgTGRMARVTTFMVDVLAGVPSIVAALFIFSLWIAtLGFQQSAFAVSLALVLLMLPVVVRSTEE 176
Cdd:COG1177   75 LLATVLGTPAALALARY-RFRGRRLLLALLLLPLVVPGIVLGVALLLLFSA-LGLSGGLWGLILAHVVFTLPFVVLVVLA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 177 MLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGysrsinldifnGNMASLPLLI 256
Cdd:COG1177  153 RLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAG-----------PGVTTLPVYI 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 576417501 257 YTELTNPehagfLRVWGAALTLIILVAVINVVAAGIRFVSTRAS 300
Cdd:COG1177  222 YSMIRRG-----ISPEINALSTLLILLSLLLLLLAERLRRRGER 260
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
19-299 8.70e-09

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 56.32  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  19 SLARRIKNSLATVVFFSSFAIALVPLVWLLWVVIERGWYAiirldWWTHSLRGVLPeefaggvyHALYGTLVQAGVAAVL 98
Cdd:COG1178    3 TRPRRRPRLLLLLLALLLALLVLLPLLALLLRAFTDGLAN-----FWALLSDPYLW--------RALGNTLLLALLVTLL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  99 AVPLGLMTAiYLVEYGTGRMARVTTFMVDVLAGVPSIVAAL----------FIFSLWIATLGFQQ----SAFAVSLALVL 164
Cdd:COG1178   70 SLLLGVPLA-WLLARTDFPGRRLLRWLLLLPLALPPYVVALawialfgpngLLNTLLRALFGLEPpdiyGLGGIILVLVL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 165 LMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLvgysrsinldi 244
Cdd:COG1178  149 FNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL----------- 217

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 576417501 245 fNGNMASLPLLIYTELTNPehagFLRVWGAALTLIILVAVINVVAAGIRFVSTRA 299
Cdd:COG1178  218 -GGGYTTLTTAIYQAWLGD----FDLGAAAALALVLLLLVLLLLLLERRLRRRRR 267
COG4590 COG4590
ABC-type uncharacterized transport system, permease component [General function prediction ...
 181-293 4.22e-08

ABC-type uncharacterized transport system, permease component [General function prediction only];


Pssm-ID: 443647 [Multi-domain]  Cd Length: 757  Bit Score: 54.46  E-value: 4.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 181 VPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYSRSINLDIFNGnMASLPLLIYTEL 260
Cdd:COG4590  634 VPKHLTQGSLALGATPWQTLTRVVLLTASPGIFSAVMIGLGRAVGETMIVLMATGNTPVMDFNIFEG-MRTLSANIAVEM 712

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 576417501 261 tnPEHAG--------FLrvwgAALTLIILVAVINVVAAGIR 293
Cdd:COG4590  713 --PESEVgsthyrvlFL----AALVLFVFTFVFNTLAEIVR 747
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 99-237 6.12e-08

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.92  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501   99 AVPLGLMTAIYLVeygtGRMARVTTFMVDVLAGVPSIVAALFIFSLWIATLgFQQSAFAVSLALVLLMLPVVVRSTEEML 178
Cdd:pfam00528   1 GIPLGIIAALRRG----RRLDRLLRPLIDLLQALPSFVLAILLVVIAILSI-LGHGILPAIILALLGWAGYARLIRRAAL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 576417501  179 RLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGYS 237
Cdd:pfam00528  76 RSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP 134
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 181-299 2.49e-06

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 48.22  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 181 VPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGysrsinldifnGNMASLPLLIYTEL 260
Cdd:COG1176  180 IDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGG-----------GKVLMIGNLIYQQF 248

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 576417501 261 TNPEHAGFlrvwGAALTLIILVAVINVVAAGIRFVSTRA 299
Cdd:COG1176  249 LSALNWPL----AAALAVVLLLIVLLVLLLYLRLLRRRR 283
PRK10971 PRK10971
sulfate/thiosulfate ABC transporter permease CysT;
88-235 6.78e-05

sulfate/thiosulfate ABC transporter permease CysT;


Pssm-ID: 182873  Cd Length: 277  Bit Score: 43.59  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  88 TLVQAGVAAVLAVPLGLMTAIYLVEYG-TGRmaRVTTFMVDVLAGVPSIVAALFIFSL---------WIATLGFQQSA-- 155
Cdd:PRK10971  63 TLLSAFVASIFNAVFGLLMAWILTRYRfPGR--TLLDALMDLPFALPTAVAGLTLASLfsvngwygeWLAKFDIKVTYtw 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 156 FAVSLALVLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVG 235
Cdd:PRK10971 141 LGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFRKVVLPELSPALLAGVALSFTRSLGEFGAVIFIAG 220
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 185-220 9.48e-04

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 40.06  E-value: 9.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 576417501 185 LREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLAL 220
Cdd:PRK09497 180 LLEAARDLGANKLQTFIRIIIPLTMPGIIAGCLLVL 215
cysT CHL00187
sulfate transport protein; Provisional
 23-226 9.77e-04

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 40.00  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  23 RIKNSLATVVFFS---SFAIALVPLVWLLWVVIERGWYAIIRLDW-----WTHSLrgvlpeefaggvyhalygTLVQAGV 94
Cdd:CHL00187   5 NFSLKFSSIYIISlsyIIFLLVLPILALLIKASQQPWSDFLQKATepialSAYSL------------------TLSMALI 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501  95 AAVLAVPLGLMTAIYLVEYG-TGRmaRVTTFMVDVLAGVPSIVAALF---------IFSLWIATLGFQQ--SAFAVSLAL 162
Cdd:CHL00187  67 AALINGFFGLLIAWVLVRYNfPGK--RLLDAAVDLPFALPTSVAGLTlatvygdngWIGHLLSHLGIQIvfTKLGVLLAM 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576417501 163 VLLMLPVVVRSTEEMLRLVPDELREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGE 226
Cdd:CHL00187 145 IFVSFPFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTGLALTFSRAIGE 208
modB PRK09421
molybdate ABC transporter permease subunit;
185-289 1.89e-03

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 39.13  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576417501 185 LREASYALGVPKWKTIVRIVVPIAMPGIVSGVLLALARIIGETAPVLVLVGysrsiNLDifnGNMASLPLLIYTELTNPE 264
Cdd:PRK09421 122 LEQAARTLGASPWRVFFTITLPLTLPGIIAGTVLAFARSLGEFGATITFVS-----NIP---GETQTIPSAMYTLIQTPG 193

                         90       100
                 ....*....|....*....|....*
gi 576417501 265 HAgflrvwGAALTLIILVAVINVVA 289
Cdd:PRK09421 194 GE------SAAARLCIISIAIALAS 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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