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Conserved domains on  [gi|576442865|gb|EUA36506|]
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glycosyl transferases group 1 family protein [Mycobacterium avium subsp. avium 2285 (R)]

Protein Classification

glycosyltransferase( domain architecture ID 10455349)

glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 21-165 9.23e-52

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


:

Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 164.37  E-value: 9.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   21 GPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHSELLAMLHRAD 100
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576442865  101 AAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:pfam00534  81 VFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDE 145
 
Name Accession Description Interval E-value
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 21-165 9.23e-52

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 164.37  E-value: 9.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   21 GPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHSELLAMLHRAD 100
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576442865  101 AAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:pfam00534  81 VFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDE 145
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-196 8.70e-50

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 165.79  E-value: 8.70e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPRRPRTGPAE---LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAG-EGTQQGWLieQARKHRV 77
Cdd:cd03801  169 IPNGVDLERFSPPLRRKLGIPPDrpvLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGgDGPLRAEL--EELELGL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  78 LKAIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAA 157
Cdd:cd03801  247 GDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADA 326

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 576442865 158 IRTVLDDPEAAQRRACAARERLTSDFDWHTVADKTAQVY 196
Cdd:cd03801  327 LLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 94-199 4.11e-29

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 105.46  E-value: 4.11e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  94 AMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDPEAAQRRAC 173
Cdd:COG0438   16 ALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                         90       100
                 ....*....|....*....|....*.
gi 576442865 174 AARERLTSDFDWHTVADKTAQVYLSA 199
Cdd:COG0438   96 AARERAEERFSWEAIAERLLALYEEL 121
glgA TIGR02095
glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) ...
 29-199 1.42e-15

glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) synthases that use ADP-glucose (EC 2.4.1.21), rather than UDP-glucose (EC 2.4.1.11) as in animals, as the glucose donor. This enzyme is found in bacteria and plants. Whether the name given is glycogen synthase or starch synthase depends on context, and therefore on substrate. [Energy metabolism, Biosynthesis and degradation of polysaccharides]


Pssm-ID: 273969 [Multi-domain]  Cd Length: 473  Bit Score: 74.61  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   29 GRLEYEKGVHDVIAALPRIRRThpGTTLTIAGEGTQ--QGWLIEQARKHrvlkAIRFVGHLEHSELLAmlHR----ADAA 102
Cdd:TIGR02095 298 SRLTQQKGVDLLLAALPELLEL--GGQLVVLGTGDPelEEALRELAERY----PGNVRVIIGYDEALA--HLiyagADFI 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  103 VLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQ------TGVSCPPRDVPALAAAIRTVLD----DPeaaQRRA 172
Cdd:TIGR02095 370 LMPSRFEPCGLTQLYAMRYGTVPIVRRTGGLADTVVDGDpeaesgTGFLFEEYDPGALLAALSRALRlyrqDP---SLWE 446

                         170       180
                  ....*....|....*....|....*..
gi 576442865  173 CAARERLTSDFDWHTVADKTAQVYLSA 199
Cdd:TIGR02095 447 ALQKNAMSQDFSWDKSAKQYVELYRSL 473
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
25-165 9.14e-14

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 69.05  E-value: 9.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIR-------FVGHLEHSELLAMLH 97
Cdd:PRK15484 196 LLYAGRISPDKGILLLMQAFEKLATAHSNLKLVVVGDPTASSKGEKAAYQKKVLEAAKrigdrciMLGGQPPEKMHNYYP 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  98 RADAAVLPSHY-EPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCP-PRDVPALAAAIRTVLDDP 165
Cdd:PRK15484 276 LADLVVVPSQVeEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAePMTSDSIISDINRTLADP 345
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 2-165 2.88e-05

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 44.15  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARW-PFAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTtltiagegtqQGWLI-------EQAR 73
Cdd:NF038011 285 IPNGIDLPRLaPLRAQRPAGIPPVVGLIGRVVPIKDIKTFIRAMRTVVRAMPEA----------EGWIVgpeeedpAYAA 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  74 KHRVLKA-------IRFVGHLEHSELLAMLhraDAAVLPSHYEPFGIVALEAAAAGTPLVTSNIG-------GLGEAviD 139
Cdd:NF038011 355 ECRSLVAslglqdkVKFLGFQKIDDLLPQV---GLMVLSSISEALPLVVLEAFAAGVPVVTTDVGscrqlieGLDEE--D 429

                        170       180
                 ....*....|....*....|....*....
gi 576442865 140 ---GQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:NF038011 430 ralGAAGEVVAIADPQALARAALDLLRDP 458
 
Name Accession Description Interval E-value
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 21-165 9.23e-52

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 164.37  E-value: 9.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   21 GPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHSELLAMLHRAD 100
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576442865  101 AAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:pfam00534  81 VFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDE 145
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-196 8.70e-50

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 165.79  E-value: 8.70e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPRRPRTGPAE---LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAG-EGTQQGWLieQARKHRV 77
Cdd:cd03801  169 IPNGVDLERFSPPLRRKLGIPPDrpvLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGgDGPLRAEL--EELELGL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  78 LKAIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAA 157
Cdd:cd03801  247 GDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADA 326

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 576442865 158 IRTVLDDPEAAQRRACAARERLTSDFDWHTVADKTAQVY 196
Cdd:cd03801  327 LLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
25-164 8.17e-39

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 130.71  E-value: 8.17e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   25 LLYLGRL-EYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQgWLIEQARKHRvlKAIRFVGHLEhsELLAMLHRADAAV 103
Cdd:pfam13692   4 ILFVGRLhPNVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEE-ELEELAAGLE--DRVIFTGFVE--DLAELLAAADVFV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576442865  104 LPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEaVIDGQTGVSCPPRDVPALAAAIRTVLDD 164
Cdd:pfam13692  79 LPSLYEGFGLKLLEAMAAGLPVVATDVGGIPE-LVDGENGLLVPPGDPEALAEAILRLLED 138
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 4-165 4.73e-38

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 135.03  E-value: 4.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   4 NGIETARWPFAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEG-----TQQgwLIEQARKHRVl 78
Cdd:cd03808  171 SGVDLDRFQYSPESLPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVGDGelenpSEI--LIEKLGLEGR- 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  79 kaIRFVGHLehSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAI 158
Cdd:cd03808  248 --IEFLGFR--SDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVPPGDVEALADAI 323


                 ....*..
gi 576442865 159 RTVLDDP 165
Cdd:cd03808  324 EKLIEDP 330
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 2-196 1.13e-37

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 134.43  E-value: 1.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARwpFAPRRPRTGPAE----LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRV 77
Cdd:cd03798  178 IPNGVDPAR--FQPEDRGLGLPLdafvILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  78 LKAIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAA 157
Cdd:cd03798  256 GDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVPPGDADALAAA 335

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 576442865 158 IRTVLDDPEAAQRRACAARERLTSdFDWHTVADKTAQVY 196
Cdd:cd03798  336 LRRALAEPYLRELGEAARARVAER-FSWVKAADRIAAAY 373
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 9-194 3.22e-31

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 117.73  E-value: 3.22e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   9 ARWPFAPRRPRtgpaeLLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAG--------EGTQQgwLIEQARKHRVLKA 80
Cdd:cd03800  212 ARLLLPPDKPV-----VLALGRLDPRKGIDTLVRAFAQLPELRELANLVLVGgpsddplsMDREE--LAELAEELGLIDR 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  81 IRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIRT 160
Cdd:cd03800  285 VRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDPHDPEALAAALRR 364

                        170       180       190
                 ....*....|....*....|....*....|....
gi 576442865 161 VLDDPEAAQRRACAARERLTSDFDWHTVADKTAQ 194
Cdd:cd03800  365 LLDDPALWQRLSRAGLERARAHYTWESVADQLLT 398
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 5-165 4.01e-30

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 113.91  E-value: 4.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   5 GIETARWP------FAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRrthpgTTLTIAGEGTQQGWLIEQARKHrVL 78
Cdd:cd03795  168 GIDKNVYNiprvdfENIKREKKGKKIFLFIGRLVYYKGLDYLIEAAQYLN-----YPIVIGGEGPLKPDLEAQIELN-LL 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  79 KAIRFVGHLEHSELLAMLHRADAAVLPSHY--EPFGIVALEAAAAGTPLVTSNIGGLGEAV-IDGQTGVSCPPRDVPALA 155
Cdd:cd03795  242 DNVKFLGRVDDEEKVIYLHLCDVFVFPSVLrsEAFGIVLLEAMMCGKPVISTNIGTGVPYVnNNGETGLVVPPKDPDALA 321

                        170
                 ....*....|
gi 576442865 156 AAIRTVLDDP 165
Cdd:cd03795  322 EAIDKLLSDE 331
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 1-165 4.66e-30

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 113.96  E-value: 4.66e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   1 MIRNGIETARWPFAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRthPGTTLTIAGEGTQqgwliEQARKHRVLKA 80
Cdd:cd03823  170 VIPNAVEPDLAPPPRRRPGTERLRFGYIGRLTEEKGIDLLVEAFKRLPR--EDIELVIAGHGPL-----SDERQIEGGRR 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  81 IRFVGHLEHSELLAMLHRADAAVLPSH-YEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIR 159
Cdd:cd03823  243 IAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFAPGDAEDLAAAMR 322


                 ....*.
gi 576442865 160 TVLDDP 165
Cdd:cd03823  323 RLLTDP 328
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 94-199 4.11e-29

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 105.46  E-value: 4.11e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  94 AMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDPEAAQRRAC 173
Cdd:COG0438   16 ALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                         90       100
                 ....*....|....*....|....*.
gi 576442865 174 AARERLTSDFDWHTVADKTAQVYLSA 199
Cdd:COG0438   96 AARERAEERFSWEAIAERLLALYEEL 121
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 5-165 1.90e-28

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 109.85  E-value: 1.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   5 GIETARwpFAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKhrvLKAIRFV 84
Cdd:cd05844  174 GIDPAK--FAPRDPAERAPTILFVGRLVEKKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAA---LGRVRFL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  85 GHLEHSELLAMLHRADAAVLPS------HYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAI 158
Cdd:cd05844  249 GALPHAEVQDWMRRAEIFCLPSvtaasgDSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGDVDALADAL 328


                 ....*..
gi 576442865 159 RTVLDDP 165
Cdd:cd05844  329 QALLADR 335
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 2-165 2.75e-28

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 108.98  E-value: 2.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPF---APRRPRTGPAE----LLYLGRLEYEKGVHDVIAALPRIRRThPGTTLTIAGEGTQQGWLIEQARK 74
Cdd:cd03819  155 IPNGVDTDRFPPeaeAEERAQLGLPEgkpvVGYVGRLSPEKGWLLLVDAAAELKDE-PDFRLLVAGDGPERDEIRRLVER 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  75 HRVLKAIRFVGHleHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPAL 154
Cdd:cd03819  234 LGLRDRVTFTGF--REDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPPGDAEAL 311

                        170
                 ....*....|.
gi 576442865 155 AAAIRTVLDDP 165
Cdd:cd03819  312 ADAIRAAKLLP 322
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 2-153 2.40e-27

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 106.98  E-value: 2.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARW----PFAPRRPRTGPAE---LLYLGRLEYEKGVHDVIAALPRIRrTHPGTTLTIAGEGTQQGWLIEQARK 74
Cdd:cd03817  174 IPNGIDLDKFekplNTEERRKLGLPPDepiLLYVGRLAKEKNIDFLLRAFAELK-KEPNIKLVIVGDGPEREELKELARE 252

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576442865  75 HRVLKAIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPA 153
Cdd:cd03817  253 LGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEPNDETL 331
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 2-165 6.34e-27

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 105.52  E-value: 6.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPRRPRTGPAE----LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRV 77
Cdd:cd03811  164 IYNPIDIDRIRALAKEPILNEPEdgpvILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  78 LKAIRFVGHleHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAA 157
Cdd:cd03811  244 AERVIFLGF--QSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAAALAGI 321


                 ....*...
gi 576442865 158 IRTVLDDP 165
Cdd:cd03811  322 LAALLQKK 329
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 2-165 2.43e-26

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 103.94  E-value: 2.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPRRPRTGPAELLY---------LGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQA 72
Cdd:cd03807  161 IYNGIDLFKLSPDDASRARARRRLGLaedrrvigiVGRLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERLL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  73 RKHRVLKAIRFVGhlEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGqTGVSCPPRDVP 152
Cdd:cd03807  241 LELGLEDRVHLLG--ERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDG-TGFLVPAGDPQ 317

                        170
                 ....*....|...
gi 576442865 153 ALAAAIRTVLDDP 165
Cdd:cd03807  318 ALADAIRALLEDP 330
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 25-194 8.91e-26

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 102.44  E-value: 8.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGegtQQGWLIE---QARKHRVLKA-IRFVGHLEHSELLAMLHRAD 100
Cdd:cd03809  195 FLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVG---GKGWEDEellDLVKKLGLGGrVRFLGYVSDEDLPALYRGAR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865 101 AAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEavIDGQTGVSCPPRDVPALAAAIRTVLDDPEAAQRRACAARERLt 180
Cdd:cd03809  272 AFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPE--VAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKGLERA- 348

                        170
                 ....*....|....
gi 576442865 181 SDFDWHTVADKTAQ 194
Cdd:cd03809  349 KKFSWEKTAEKTLE 362
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 25-165 1.59e-24

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 98.85  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHSELLamLHRADAAVL 104
Cdd:cd03820  184 ILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPTKNIAEE--YANSSIFVL 261

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 576442865 105 PSHYEPFGIVALEAAAAGTPLVTSNI-GGLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:cd03820  262 SSRYEGFPMVLLEAMAYGLPIISFDCpTGPSEIIEDGENGLLVPNGDVDALAEALLRLMEDE 323
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 2-194 1.61e-23

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 96.67  E-value: 1.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPRRPRTGPA-----ELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQgwliEQARKHR 76
Cdd:cd03821  179 IPNGVDIPEFDPGLRDRRKHNGledrrIILFLGRIHPKKGLDLLIRAARKLAEQGRDWHLVIAGPDDGA----YPAFLQL 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  77 VLKA-----IRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLgEAVIDGQTGVSCPPRDv 151
Cdd:cd03821  255 QSSLglgdrVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGL-SELVEAGCGVVVDPNV- 332

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 576442865 152 PALAAAIRTVLDDPEAAQR--RACAARERLTSDFDWHTVADKTAQ 194
Cdd:cd03821  333 SSLAEALAEALRDPADRKRlgEMARRARQVEENFSWEAVAGQLGE 377
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 2-196 5.53e-23

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 95.11  E-value: 5.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAP----RRPRTGPAE---LLYLGRLEYEKGVHDVIAALPRIRRTHPgTTLTIAGEGTQQGWLIEQARK 74
Cdd:cd04962  169 IHNFIDEDVFKRKPagalKRRLLAPPDekvVIHVSNFRPVKRIDDVVRVFARVRRKIP-AKLLLVGDGPERVPAEELARE 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  75 HRVLKAIRFVGHLEHSELLamLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPAL 154
Cdd:cd04962  248 LGVEDRVLFLGKQDDVEEL--LSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDVGDVDAM 325

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 576442865 155 AAAIRTVLDDPEAAQRRACAARERLTSDFDWHTVADKTAQVY 196
Cdd:cd04962  326 AKSALSILEDDELYNRMGRAARKRAAERFDPERIVPQYEAYY 367
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 26-143 8.75e-22

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 89.39  E-value: 8.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  26 LYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHSELLAMLHR-ADAAVL 104
Cdd:cd01635  114 VSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAaADVFVL 193

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 576442865 105 PSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTG 143
Cdd:cd01635  194 PSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENG 232
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 2-161 2.83e-20

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 86.96  E-value: 2.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPRRPRTgpaeLLYLGRLEYEKGVHDVIAALPRIRRThpgttLTIAGE-GTQQGWLIEQARkhRVLKA 80
Cdd:cd03802  153 VHNGLDPADYRFQPDPEDY----LAFLGRIAPEKGLEDAIRVARRAGLP-----LKIAGKvRDEDYFYYLQEP--LPGPR 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  81 IRFVGHLEHSELLAMLHRADAAVLPSHY-EPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPrdVPALAAAIR 159
Cdd:cd03802  222 IEFIGEVGHDEKQELLGGARALLFPINWdEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDS--VEEMAEAIA 299


                 ..
gi 576442865 160 TV 161
Cdd:cd03802  300 NI 301
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 5-165 3.15e-20

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 87.35  E-value: 3.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   5 GIETARwpFAPR------RPRTGPAE---LLYLGRLEYEKGVH---DVIAALPRirrtHPGTTLTIAGEGTQQGWLieqa 72
Cdd:cd03814  174 GVDTEL--FHPSrrdaalRRRLGPPGrplLLYVGRLAPEKNLEallDADLPLAA----SPPVRLVVVGDGPARAEL---- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  73 rKHRVLKAIrFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVP 152
Cdd:cd03814  244 -EARGPDVI-FTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDAA 321

                        170
                 ....*....|...
gi 576442865 153 ALAAAIRTVLDDP 165
Cdd:cd03814  322 AFAAALRALLEDP 334
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 2-196 2.19e-19

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 85.08  E-value: 2.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPR---RPRTG---PAELLYLGRLEYE---KGVHDVIAALPRIRrTHPGTTLTIAGEGTQQ-GWLieq 71
Cdd:cd03825  166 IPNGIDTEIFAPVDKakaRKRLGipqDKKVILFGAESVTkprKGFDELIEALKLLA-TKDDLLLVVFGKNDPQiVIL--- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  72 arKHRvlkaIRFVGHLEHSELLAMLHR-ADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRD 150
Cdd:cd03825  242 --PFD----IISLGYIDDDEQLVDIYSaADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGD 315

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 576442865 151 VPALAAAIRTVLDDPEAAQRRACAARERLTSDFDWHTVADKTAQVY 196
Cdd:cd03825  316 VQALAEAIEWLLANPKERESLGERARALAENHFDQRVQAQRYLELY 361
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 1-165 6.34e-17

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 78.15  E-value: 6.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   1 MIRNGIETARWP------FAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRtHPGTTLTIAGEGTQQGWLIEQARK 74
Cdd:cd03794  190 VIPNWADLEEFKpppkdeLRKKLGLDDKFVVVYAGNIGKAQGLETLLEAAERLKR-RPDIRFLFVGDGDEKERLKELAKA 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  75 hRVLKAIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVA-----LEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPR 149
Cdd:cd03794  269 -RGLDNVTFLGRVPKEEVPELLSAADVGLVPLKDNPANRGSspsklFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPG 347

                        170
                 ....*....|....*.
gi 576442865 150 DVPALAAAIRTVLDDP 165
Cdd:cd03794  348 DPEALADAILELLDDP 363
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 3-191 1.56e-16

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 76.72  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   3 RNGIETARWPFAPRR-PRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAI 81
Cdd:cd03799  154 RSGIDCNKFRFKPRYlPLDGKIRILTVGRLTEKKGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  82 RFVGHLEHSELLAMLHRADAAVLPS------HYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALA 155
Cdd:cd03799  234 KLLGWKPQEEIIEILDEADIFIAPSvtaadgDQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVPERDAEAIA 313

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 576442865 156 AAIRTVLDDPEAAQRRACAARERLTSDFDWHTVADK 191
Cdd:cd03799  314 EKLTYLIEHPAIWPEMGKAGRARVEEEYDINKLNDE 349
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 1-206 9.08e-16

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 74.97  E-value: 9.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   1 MIRNGIETARWPFAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGwLIEQAR-KHRVLK 79
Cdd:cd03796  172 VIPNAVDSSDFTPDPSKPDPNKITIVVISRLVYRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRI-ELEEMReKYQLQD 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  80 AIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPprDVPALAAAIR 159
Cdd:cd03796  251 RVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCIAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEP--DPEDIVRKLE 328

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 576442865 160 TVLDDPEAAQRRACAARERLTSDFDWHTVADKTAQVYLSAKRAERQP 206
Cdd:cd03796  329 EAISILRTGKHDPWSFHNRVKKMYSWEDVARRTEKVYDRILSTPNRP 375
glgA TIGR02095
glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) ...
 29-199 1.42e-15

glycogen/starch synthase, ADP-glucose type; This family consists of glycogen (or starch) synthases that use ADP-glucose (EC 2.4.1.21), rather than UDP-glucose (EC 2.4.1.11) as in animals, as the glucose donor. This enzyme is found in bacteria and plants. Whether the name given is glycogen synthase or starch synthase depends on context, and therefore on substrate. [Energy metabolism, Biosynthesis and degradation of polysaccharides]


Pssm-ID: 273969 [Multi-domain]  Cd Length: 473  Bit Score: 74.61  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   29 GRLEYEKGVHDVIAALPRIRRThpGTTLTIAGEGTQ--QGWLIEQARKHrvlkAIRFVGHLEHSELLAmlHR----ADAA 102
Cdd:TIGR02095 298 SRLTQQKGVDLLLAALPELLEL--GGQLVVLGTGDPelEEALRELAERY----PGNVRVIIGYDEALA--HLiyagADFI 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  103 VLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQ------TGVSCPPRDVPALAAAIRTVLD----DPeaaQRRA 172
Cdd:TIGR02095 370 LMPSRFEPCGLTQLYAMRYGTVPIVRRTGGLADTVVDGDpeaesgTGFLFEEYDPGALLAALSRALRlyrqDP---SLWE 446

                         170       180
                  ....*....|....*....|....*..
gi 576442865  173 CAARERLTSDFDWHTVADKTAQVYLSA 199
Cdd:TIGR02095 447 ALQKNAMSQDFSWDKSAKQYVELYRSL 473
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 25-165 3.96e-15

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 72.72  E-value: 3.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHleHSELLAMLHRADAAVL 104
Cdd:cd04949  163 IITISRLAPEKQLDHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGY--HSNLDQEYQDAYLSLL 240

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 576442865 105 PSHYEPFGIVALEAAAAGTPLVTSNIG-GLGEAVIDGQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:cd04949  241 TSQMEGFGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYLIEKNNIDALADKIIELLNDP 302
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 29-198 3.31e-14

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 70.67  E-value: 3.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  29 GRLEYEKGVHDVIAALPRIRRThpGTTLTIAGEGTQ--QGWLIEQARKHRVlkaiRFVGHLEHSELLAmlHR----ADAA 102
Cdd:cd03791  301 GRLTEQKGVDLILDALPELLEE--GGQLVVLGSGDPeyEQAFRELAERYPG----KVAVVIGFDEALA--HRiyagADFF 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865 103 VLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDG------QTGVSCPPRDVPALAAAIRTVLDDPEAAQRRACAAR 176
Cdd:cd03791  373 LMPSRFEPCGLVQMYAMRYGTLPIVRRTGGLADTVFDYdpetgeGTGFVFEDYDAEALLAALRRALALYRNPELWRKLQK 452

                        170       180
                 ....*....|....*....|..
gi 576442865 177 ERLTSDFDWHTVADKTAQVYLS 198
Cdd:cd03791  453 NAMKQDFSWDKSAKEYLELYRS 474
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
25-165 9.14e-14

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 69.05  E-value: 9.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIR-------FVGHLEHSELLAMLH 97
Cdd:PRK15484 196 LLYAGRISPDKGILLLMQAFEKLATAHSNLKLVVVGDPTASSKGEKAAYQKKVLEAAKrigdrciMLGGQPPEKMHNYYP 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  98 RADAAVLPSHY-EPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCP-PRDVPALAAAIRTVLDDP 165
Cdd:PRK15484 276 LADLVVVPSQVeEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAePMTSDSIISDINRTLADP 345
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 26-158 4.75e-13

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 66.92  E-value: 4.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  26 LYLGRLEYEKGVHDVIAALPRIrrthpGTTLTIAGEGTQQGWLIEQARKHrvlkaIRFVGHLEHSELLAMLHRADAAVLP 105
Cdd:cd03804  203 LTASRLVPYKRIDLAVEAFNEL-----PKRLVVIGDGPDLDRLRAMASPN-----VEFLGYQPDEVLKELLSKARAFVFA 272

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 576442865 106 SHyEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVPALAAAI 158
Cdd:cd03804  273 AE-EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTGILFGEQTVESLKAAV 324
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 2-165 2.11e-12

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 65.08  E-value: 2.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARW-PFAPRRPRTGPAELL--------YLGR-LEYEKGVHDVIAALPRIRRTHPGT-TLTIAGEGTQQG---- 66
Cdd:cd03818  184 IHDGVDTDRLaPDPAARLRLLNGTELkagdpvitYVARnLEPYRGFHVFMRALPRIQARRPDArVVVVGGDGVSYGsppp 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  67 ----WLIEQARKHRV-LKAIRFVGHLEHSELLAMLHRADAAVLPShyEPFgiVA----LEAAAAGTPLVTSNIGGLGEAV 137
Cdd:cd03818  264 dggsWKQKMLAELGVdLERVHFVGKVPYDQYVRLLQLSDAHVYLT--YPF--VLswslLEAMACGCPVIGSDTAPVREVI 339

                        170       180
                 ....*....|....*....|....*...
gi 576442865 138 IDGQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:cd03818  340 RDGRNGLLVDFFDPDALAAAVLELLEDP 367
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 2-165 2.50e-12

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 65.05  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARWPFAPR-RPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAG-EGTQQGWLIE---QARKHR 76
Cdd:cd03813  272 IPNGIDIQRFAPAREeRPEKEPPVVGLVGRVVPIKDVKTFIRAFKLVRRAMPDAEGWLIGpEDEDPEYAQEckrLVASLG 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  77 VLKAIRFVGHLEHSELLAMLhraDAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVID-----GQTGVSCPPRDV 151
Cdd:cd03813  352 LENKVKFLGFQNIKEYYPKL---GLLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIYGaddalGQAGLVVPPADP 428

                        170
                 ....*....|....
gi 576442865 152 PALAAAIRTVLDDP 165
Cdd:cd03813  429 EALAEALIKLLRDP 442
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 3-165 3.02e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 64.73  E-value: 3.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   3 RNGIETARwpFAPR--------RPRTGPAE---LLYLGRLEYEKGVHDVIAALPRIrrthPGTTLTIAGEGTQQgwliEQ 71
Cdd:PLN02871 235 NKGVDSES--FHPRfrseemraRLSGGEPEkplIVYVGRLGAEKNLDFLKRVMERL----PGARLAFVGDGPYR----EE 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  72 ARKHRVLKAIRFVGHLEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVS---CPP 148
Cdd:PLN02871 305 LEKMFAGTPTVFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIPPDQEGKTgflYTP 384

                        170
                 ....*....|....*..
gi 576442865 149 RDVPALAAAIRTVLDDP 165
Cdd:PLN02871 385 GDVDDCVEKLETLLADP 401
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 25-196 4.37e-11

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 61.25  E-value: 4.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGE--GTQQGWLIEQARKHR-----VLKAIRFV-GHLEHSELLAML 96
Cdd:cd03822  190 ILTFGFIGPGKGLEILLEALPELKAEFPDVRLVIAGElhPSLARYEGERYRKAAieelgLQDHVDFHnNFLPEEEVPRYI 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  97 HRADAAVLPSHYEPFGI--VALEAAAAGTPLVTSNIGGLGEAVIDGQtGVSCPPRDVPALAAAIRTVLDDPeAAQRRACA 174
Cdd:cd03822  270 SAADVVVLPYLNTEQSSsgTLSYAIACGKPVISTPLRHAEELLADGR-GVLVPFDDPSAIAEAILRLLEDD-ERRQAIAE 347

                        170       180
                 ....*....|....*....|..
gi 576442865 175 ARERLTSDFDWHTVADKTAQVY 196
Cdd:cd03822  348 RAYAYARAMTWESIADRYLRLF 369
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 27-138 1.13e-10

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 60.00  E-value: 1.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  27 YLGRLEYEKGvH----DVIAALPRIRrthPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEH-SELLAMLhraDA 101
Cdd:cd03812  196 HVGRFNEQKN-HsfliDIFEELKKKN---PNVKLVLVGEGELKEKIKEKVKELGLEDKVIFLGFRNDvSEILSAM---DV 268

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 576442865 102 AVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLgEAVI 138
Cdd:cd03812  269 FLFPSLYEGLPLVAVEAQASGLPCLLSDTITK-ECDI 304
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 25-198 1.51e-10

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 59.77  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGhlEHSELLAMLHRADAAVL 104
Cdd:cd04951  191 ILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLG--QISNISEYYNAADLFVL 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865 105 PSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVscPPRDVPALAAAIRTVLDDPEAAQRRACAARERLTSDFD 184
Cdd:cd04951  269 SSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVV--PVSDPQLLAEKIKEIFDMSDEERDILGNKNEYIAKNFS 346

                        170
                 ....*....|....
gi 576442865 185 WHTVADKTAQVYLS 198
Cdd:cd04951  347 INTIVNEWERLYSG 360
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 30-163 2.03e-10

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 59.66  E-value: 2.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  30 RLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHseLLAMLHRADAAVLPSHYE 109
Cdd:PRK15179 525 RVDDNKRPFLWVEAAQRFAASHPKVRFIMVGGGPLLESVREFAQRLGMGERILFTGLSRR--VGYWLTQFNAFLLLSRFE 602

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 576442865 110 PFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDV--PALAAAIRTVLD 163
Cdd:PRK15179 603 GLPNVLIEAQFSGVPVVTTLAGGAGEAVQEGVTGLTLPADTVtaPDVAEALARIHD 658
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 96-165 9.62e-10

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 57.60  E-value: 9.62e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  96 LHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDVpALAAAIRTVLDDP 165
Cdd:cd03805  297 LSSALALLYTPSNEHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCEPTPE-AFAEAMLKLANDP 365
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
29-196 1.12e-08

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 54.33  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  29 GRLEYEKGVHDVIAALPRIRRThpGTTLTIAGEGTQ--QGWLIEQARKHRVlkaiRFVGHLEHSELLAmlHR----ADAA 102
Cdd:COG0297  302 SRLTEQKGLDLLLEALDELLEE--DVQLVVLGSGDPeyEEAFRELAARYPG----RVAVYIGYDEALA--HRiyagADFF 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865 103 VLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQ------TGVSCPPRDVPALAAAIRTVLD---DPeaaqrrac 173
Cdd:COG0297  374 LMPSRFEPCGLNQMYALRYGTVPIVRRTGGLADTVIDYNeatgegTGFVFDEYTAEALLAAIRRALAlyrDP-------- 445

                        170       180
                 ....*....|....*....|....*...
gi 576442865 174 AARERL-----TSDFDWHTVADKTAQVY 196
Cdd:COG0297  446 EAWRKLqrnamKQDFSWEKSAKEYLELY 473
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 25-165 5.15e-08

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 52.32  E-value: 5.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  25 LLYLGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQ---QGWLI-----EQARKHRVLKAIRFVGhlEHSELLAML 96
Cdd:cd03792  200 ILQVARFDPSKDPLGVIDAYKLFKRRAEEPQLVICGHGAVddpEGSVVyeevmEYAGDDHDIHVLRLPP--SDQEINALQ 277

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576442865  97 HRADAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCPPRDvpALAAAIRTVLDDP 165
Cdd:cd03792  278 RAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVE--GAAVRILRLLTDP 344
PRK14099 PRK14099
glycogen synthase GlgA;
22-206 5.46e-08

glycogen synthase GlgA;


Pssm-ID: 237610 [Multi-domain]  Cd Length: 485  Bit Score: 52.41  E-value: 5.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  22 PAELLY--LGRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKH--RVLKAIRFvghlehSELLAMLH 97
Cdd:PRK14099 293 PDALLLgvISRLSWQKGLDLLLEALPTLLGEGAQLALLGSGDAELEARFRAAAQAYpgQIGVVIGY------DEALAHLI 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  98 RA--DAAVLPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQ---------TGVSCPPRDVPALAAAIRTVLDDPE 166
Cdd:PRK14099 367 QAgaDALLVPSRFEPCGLTQLCALRYGAVPVVARVGGLADTVVDANemaiatgvaTGVQFSPVTADALAAALRKTAALFA 446

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 576442865 167 AAQRRACAARERLTSDFDWHTVADKTAQVYLSAKrAERQP 206
Cdd:PRK14099 447 DPVAWRRLQRNGMTTDVSWRNPAQHYAALYRSLV-AERRP 485
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
15-155 2.48e-07

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 50.09  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  15 PRRPRTGPAELLYLGRLEYE--KGVHDVIAALPRirrTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEH--S 90
Cdd:PRK09922 173 PPPERDKPAVFLYVGRLKFEgqKNVKELFDGLSQ---TTGEWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQpwE 249

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 576442865  91 ELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPLVTSN-IGGLGEAVIDGQTGVSCPPRDVPALA 155
Cdd:PRK09922 250 VVQQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCISSDcMSGPRDIIKPGLNGELYTPGNIDEFV 315
glgA PRK00654
glycogen synthase GlgA;
29-196 4.19e-07

glycogen synthase GlgA;


Pssm-ID: 234809 [Multi-domain]  Cd Length: 466  Bit Score: 49.73  E-value: 4.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  29 GRLEYEKGVHDVIAALPRIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVlkaiRFVGHLEHSELLAmlHR----ADAAVL 104
Cdd:PRK00654 289 SRLTEQKGLDLVLEALPELLEQGGQLVLLGTGDPELEEAFRALAARYPG----KVGVQIGYDEALA--HRiyagADMFLM 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865 105 PSHYEPFGIVALEAAAAGT-PLVtSNIGGLGEAVIDGQ------TGVSCPPRDVPALAAAIRTVLD---DPeaaQRRACA 174
Cdd:PRK00654 363 PSRFEPCGLTQLYALRYGTlPIV-RRTGGLADTVIDYNpedgeaTGFVFDDFNAEDLLRALRRALElyrQP---PLWRAL 438

                        170       180
                 ....*....|....*....|..
gi 576442865 175 ARERLTSDFDWHTVADKTAQVY 196
Cdd:PRK00654 439 QRQAMAQDFSWDKSAEEYLELY 460
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
46-143 2.20e-05

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 44.69  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  46 RIRRTHPGTTLTIAGEGTQQGWLIEQARKHRVLKAIRFVGhlEHSELLAMLHRADAAVLPSHYEPFGIVALEAAAAGTPL 125
Cdd:PRK15490 422 RYLQHHPATRFVLVGDGDLRAEAQKRAEQLGILERILFVG--ASRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPV 499

                         90
                 ....*....|....*...
gi 576442865 126 VTSNIGGLGEAVIDGQTG 143
Cdd:PRK15490 500 ISTPAGGSAECFIEGVSG 517
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 2-165 2.88e-05

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 44.15  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   2 IRNGIETARW-PFAPRRPRTGPAELLYLGRLEYEKGVHDVIAALPRIRRTHPGTtltiagegtqQGWLI-------EQAR 73
Cdd:NF038011 285 IPNGIDLPRLaPLRAQRPAGIPPVVGLIGRVVPIKDIKTFIRAMRTVVRAMPEA----------EGWIVgpeeedpAYAA 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  74 KHRVLKA-------IRFVGHLEHSELLAMLhraDAAVLPSHYEPFGIVALEAAAAGTPLVTSNIG-------GLGEAviD 139
Cdd:NF038011 355 ECRSLVAslglqdkVKFLGFQKIDDLLPQV---GLMVLSSISEALPLVVLEAFAAGVPVVTTDVGscrqlieGLDEE--D 429

                        170       180
                 ....*....|....*....|....*....
gi 576442865 140 ---GQTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:NF038011 430 ralGAAGEVVAIADPQALARAALDLLRDP 458
GT3_GSY2-like cd03793
glycogen synthase GSY2 and similar proteins; Glycogen synthase, which is most closely related ...
 103-134 1.31e-03

glycogen synthase GSY2 and similar proteins; Glycogen synthase, which is most closely related to the GT3 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the member of this family in S. cerevisiae, has been shown to possess glycogen synthase activity.


Pssm-ID: 340824 [Multi-domain]  Cd Length: 590  Bit Score: 39.28  E-value: 1.31e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 576442865 103 VLPSHYEPFGIVALEAAAAGTPLVTSNIGGLG 134
Cdd:cd03793  479 VFPSYYEPWGYTPAECTVMGIPSITTNLSGFG 510
PRK10307 PRK10307
colanic acid biosynthesis glycosyltransferase WcaI;
1-165 2.23e-03

colanic acid biosynthesis glycosyltransferase WcaI;


Pssm-ID: 236670 [Multi-domain]  Cd Length: 412  Bit Score: 38.42  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865   1 MIRNGIETARWPFAPRRPRTG-------PAE---LLYLGRLEYEKGVHDVIAALPRIRrTHPGTTLTIAGEGTQQGWLIE 70
Cdd:PRK10307 198 FFPNWSEVARFQPVADADVDAlraqlglPDGkkiVLYSGNIGEKQGLELVIDAARRLR-DRPDLIFVICGQGGGKARLEK 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  71 QARKhRVLKAIRFVgHLEHSE----LLAM--LH----RADAA--VLPSHYEpfGIVAleaaaAGTPLV-TSNIG-GLGEA 136
Cdd:PRK10307 277 MAQC-RGLPNVHFL-PLQPYDrlpaLLKMadCHllpqKAGAAdlVLPSKLT--NMLA-----SGRNVVaTAEPGtELGQL 347

                        170       180
                 ....*....|....*....|....*....
gi 576442865 137 VIDgqTGVSCPPRDVPALAAAIRTVLDDP 165
Cdd:PRK10307 348 VEG--IGVCVEPESVEALVAAIAALARQA 374
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
104-165 3.75e-03

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 35.66  E-value: 3.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 576442865  104 LPSHYEPFGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGVSCppRDVPALAAAIRTVLDDP 165
Cdd:pfam13524   5 PSRRPDSPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILLY--RDPEELAEKIRYLLEHP 64
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 35-165 6.80e-03

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 37.05  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576442865  35 KGVHDVIAALPRIRRTHPGTTL--TIAGEGTQQGWLIEQARKHRVLKAIRFVGHLEHSELLA--MLHRADAAVLPSHYEP 110
Cdd:cd04946  237 KRIDLIIETLNSLCVAHPSICIswTHIGGGPLKERLEKLAENKLENVKVNFTGEVSNKEVKQlyKENDVDVFVNVSESEG 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 576442865 111 FGIVALEAAAAGTPLVTSNIGGLGEAVIDGQTGV----SCPPRDvpaLAAAIRTVLDDP 165
Cdd:cd04946  317 IPVSIMEAISFGIPVIATNVGGTREIVENETNGLlldkDPTPNE---IVSSIMKFYLDG 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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