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Conserved domains on  [gi|577611014|gb|EUI22849|]
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nitroreductase [Staphylococcus aureus M1427]

Protein Classification

nitroreductase( domain architecture ID 10114819)

nitroreductase catalyzes the reduction of flavin or nitrocompounds using NAD(P)H as electron donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 5-158 1.95e-50

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


:

Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 159.69  E-value: 1.95e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   5 QAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFA----FPNELEKQQCHYD 80
Cdd:cd02135    2 ELIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAaaraPGADPEKLEKARE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577611014  81 AVTKLGGMLLLILKTDPR-QRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYL 158
Cdd:cd02135   82 KALRAPVVIAVVAKPDEDpKVPEWEQYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPAVREALGLPEDERIVGFLYL 160
 
Name Accession Description Interval E-value
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 5-158 1.95e-50

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 159.69  E-value: 1.95e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   5 QAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFA----FPNELEKQQCHYD 80
Cdd:cd02135    2 ELIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAaaraPGADPEKLEKARE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577611014  81 AVTKLGGMLLLILKTDPR-QRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYL 158
Cdd:cd02135   82 KALRAPVVIAVVAKPDEDpKVPEWEQYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPAVREALGLPEDERIVGFLYL 160
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-171 1.65e-27

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 101.08  E-value: 1.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   3 LQQAIANRRSVKKFKRDMhIDDALLYQAIEKAADAPNHGMREPWRVVHV----PKDRLGDMskdiskfafpNELEKQQCH 78
Cdd:COG0778    1 LLELLLTRRSVRKFTDKP-VSDEELEELLEAARLAPSAGNLQPWRFVVVrdpeLRERLAEA----------LAEANQEWV 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014  79 YDAvtklgGMLLLILkTDPRQRQNDENYFAF---GAYAQNLMLLLYEAGIGTCWKSPlyIYDPKVRKTLGIKKDEVLAGF 155
Cdd:COG0778   70 ADA-----PVLIVVC-ADPDRSEKVPERYALldaGIAAQNLLLAARALGLGTCWIGG--FDPEKVRELLGLPEGEEPVAL 141

                        170
                 ....*....|....*.
gi 577611014 156 LYLTDLEGDMPKAPRK 171
Cdd:COG0778  142 LALGYPAEELNPRPRK 157
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-158 3.67e-22

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 87.45  E-value: 3.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014    7 IANRRSVKKFKRDmHIDDALLYQAIEKAADAPNHGMREPWRVVHVP----KDRLGDMSKDiSKFAFPNELEKQQCHYDAV 82
Cdd:pfam00881   1 IRQRRSVRKFDPE-PVPKEVLEEILEAARRAPSAGNLQPWRFYVVTdgelRYRLAEAALE-LLLVEPAAALLLLLRRDAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   83 TKLG--------GMLLLILKTDPRQ------RQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSplYIYDPKVRKTLGIKK 148
Cdd:pfam00881  79 LKLLlqdflrgaPVLIVITASLSTYlrkaaeRAYREALLDAGAAAQNLLLAATSLGLGSCPIG--GFDAAAVRELLGLPD 156

                         170
                  ....*....|
gi 577611014  149 DEVLAGFLYL 158
Cdd:pfam00881 157 DERLVGLIAV 166
 
Name Accession Description Interval E-value
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 5-158 1.95e-50

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 159.69  E-value: 1.95e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   5 QAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFA----FPNELEKQQCHYD 80
Cdd:cd02135    2 ELIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAaaraPGADPEKLEKARE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577611014  81 AVTKLGGMLLLILKTDPR-QRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYL 158
Cdd:cd02135   82 KALRAPVVIAVVAKPDEDpKVPEWEQYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPAVREALGLPEDERIVGFLYL 160
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-171 1.65e-27

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 101.08  E-value: 1.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   3 LQQAIANRRSVKKFKRDMhIDDALLYQAIEKAADAPNHGMREPWRVVHV----PKDRLGDMskdiskfafpNELEKQQCH 78
Cdd:COG0778    1 LLELLLTRRSVRKFTDKP-VSDEELEELLEAARLAPSAGNLQPWRFVVVrdpeLRERLAEA----------LAEANQEWV 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014  79 YDAvtklgGMLLLILkTDPRQRQNDENYFAF---GAYAQNLMLLLYEAGIGTCWKSPlyIYDPKVRKTLGIKKDEVLAGF 155
Cdd:COG0778   70 ADA-----PVLIVVC-ADPDRSEKVPERYALldaGIAAQNLLLAARALGLGTCWIGG--FDPEKVRELLGLPEGEEPVAL 141

                        170
                 ....*....|....*.
gi 577611014 156 LYLTDLEGDMPKAPRK 171
Cdd:COG0778  142 LALGYPAEELNPRPRK 157
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-158 3.67e-22

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 87.45  E-value: 3.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014    7 IANRRSVKKFKRDmHIDDALLYQAIEKAADAPNHGMREPWRVVHVP----KDRLGDMSKDiSKFAFPNELEKQQCHYDAV 82
Cdd:pfam00881   1 IRQRRSVRKFDPE-PVPKEVLEEILEAARRAPSAGNLQPWRFYVVTdgelRYRLAEAALE-LLLVEPAAALLLLLRRDAN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   83 TKLG--------GMLLLILKTDPRQ------RQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSplYIYDPKVRKTLGIKK 148
Cdd:pfam00881  79 LKLLlqdflrgaPVLIVITASLSTYlrkaaeRAYREALLDAGAAAQNLLLAATSLGLGSCPIG--GFDAAAVRELLGLPD 156

                         170
                  ....*....|
gi 577611014  149 DEVLAGFLYL 158
Cdd:pfam00881 157 DERLVGLIAV 166
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 6-156 1.37e-19

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 80.32  E-value: 1.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   6 AIANRRSVKKFKRDMhIDDALLYQAIEKAADAPNHGMREPWRVvHVPKDRLGDMSKDISkfafpnelekqqchYDAVTkl 85
Cdd:cd02136    1 AIKSRRSVRAFKDKP-VPKETIEKILEAARRAPSGKNTQPWRV-YVVTGKARERLKKAF--------------FGAPV-- 62

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 577611014  86 ggmlLLILKTDPRQRQNDenYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFL 156
Cdd:cd02136   63 ----ALFLTMDKVLGPWS--WFDLGAFLQNLMLAAHALGLGTCPQGALAGYPDVVRKELGIPDDEELVCGI 127
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-158 7.56e-17

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 72.71  E-value: 7.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   7 IANRRSVKKFKRDMhIDDALLYQAIEKAADAPNHGMREPWRVVhVPKDRlgDMSKDISKFAFPNelekqQCH-YDAVtkl 85
Cdd:cd02062    1 IKTRRSIRKFTDKP-VPEEKLRKILEAARLAPSAGNLQPWRFI-VVRDR--EKKEKLAKLAAPN-----QKFiAGAP--- 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577611014  86 ggmLLLILKTDPRQRQNDENYFAfGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYL 158
Cdd:cd02062   69 ---VVIVVVADPDKSRPWALEDA-GAAAQNLLLAAAALGLGSCWIGGFDFREDKVRELLGIPENLRPVALIAI 137
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 5-146 1.46e-13

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 64.28  E-value: 1.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   5 QAIANRRSVKKFKrDMHIDDALLYQAIEKAADAPNHGMREPWRVVHV-PKDRLGDMSKdisKFAFPNELEKqqchyDAvt 83
Cdd:cd20608    2 EAIKTRRSVRRFS-DKPVEEEKLEKILEAARLAPSWANKQCWRFIVVtDKETLSELAK---KESPSNGWLK-----DA-- 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 577611014  84 klggMLLLILKTDPRQ--RQNDENYFAF--GAYAQNLMLLLYEAGIGTCWkspLYIYDP-KVRKTLGI 146
Cdd:cd20608   71 ----PVIIVVCADPKDsgWLNGQNYYLVdaAIAMQNLMLAATDLGLGTCW---IGAFDEkKVKEILGI 131
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-153 3.44e-09

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 53.05  E-value: 3.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   7 IANRRSVKKFKRDMHIDDALLyQAIEKAADAPNhGM-REPWR-VVHVPKDRLGDMSKDISKFA--FPNELEKQ------- 75
Cdd:cd20610    1 IKKRRSIRKFKPDPVPKEDIE-KILEAANWAPS-GMnRQNWEfVVVKGGEKIEKIGISIKKKNeeIARLLEKVfaekpir 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014  76 -QCHYDAVTKLGGMLLLIL----KTDPRQRQNdENYFAFGAYAQNLMLLLYEAGIGTCW-KSPLYIyDPKVRKTLGIKKD 149
Cdd:cd20610   79 fRKFRRFFTLFGGAPVLVVvytePYKPPEERK-PDLQSVSAAIQNLLLAAHALGLGTCWmTGPLYA-EDEIEEILEIPDD 156


                 ....
gi 577611014 150 EVLA 153
Cdd:cd20610  157 KELV 160
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 4-151 1.56e-07

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 48.39  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   4 QQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVpkdrlgdMSKDISKFAFPNELEKQQCHYDAVt 83
Cdd:cd02137    1 LEVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVV-------RDPELKAKLAEAAYNQPQVTTASA- 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577611014  84 klggmlLLILKTDPRQrqndenyfafGAYAQNLMLLLYEAGIGTCwksPLYIYD-PKVRKTLGIKKDEV 151
Cdd:cd02137   73 ------VILVLGDLNA----------GLAAMNLMLAAKAKGYDTC---PMGGFDkEKVAELLNLPDRYV 122
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 5-156 1.61e-07

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 48.89  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   5 QAIANRRSVKKFKRDmHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELE----KQQCHYD 80
Cdd:cd02145    2 RVIRWRRDVRHFRPD-PVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHELFQRANAEAAEmytgERAAQYR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014  81 AVtKLGGM----LLLILKTDP---------RQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSplyIYDPK-VRKTLGI 146
Cdd:cd02145   81 TL-KLEGIeeapLQLAVFCDRaragghglgRTTMPEMDLYSSVCAVQNLWLAARAEGLGVGWVS---ILDPDeVKRLLGI 156

                        170
                 ....*....|
gi 577611014 147 KKDEVLAGFL 156
Cdd:cd02145  157 PEHWEPVAYL 166
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 5-172 7.44e-06

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 44.00  E-value: 7.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014   5 QAIANRRSVKKFKrDMHIDDALLYQAIEKAADAPNHGMREPWRVVhVPKDRlgDMSKDISKfAFPNelekQQCHYDAvtk 84
Cdd:cd02139    3 EAIKKRRSIRKYK-PTPVEEEKLLRILEAARLAPSAKNRQPWRFI-VVKDK--ELKEKLAE-AANG----QKFIAEA--- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577611014  85 lggmLLLI----LKTDPRQRQNDENYFAFGAYA-QNLMLLLYEAGIGTCWksplyI---YDPKVRKTLGIKKD-EVLAgf 155
Cdd:cd02139   71 ----PVVIvacaDPSESGMGCGKPYYLVDVAIAmEHLVLAATEEGLGTCW-----IgafDEDKVKEILGIPEEyRVVA-- 139

                        170       180
                 ....*....|....*....|.
gi 577611014 156 lyLTDL----EGDMPKaPRKN 172
Cdd:cd02139  140 --LTPLgypaEEPPPR-PRKP 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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