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Conserved domains on  [gi|578215912|gb|EUL76111|]
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ArsR family transcriptional regulator [Klebsiella aerogenes UCI 28]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_CRP super family cl46859
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 6-112 7.02e-63

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


The actual alignment was detected with superfamily member PRK10141:

Pssm-ID: 481199  Cd Length: 117  Bit Score: 186.95  E-value: 7.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578215912   6 TMIKPIQLFKILGDETRLAIIMLLRESGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPHMPAWA 85
Cdd:PRK10141   2 SFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81

                         90       100
                 ....*....|....*....|....*..
gi 578215912  86 AEIIATTRQSMREDIDEWRKKTACATC 112
Cdd:PRK10141  82 AKIIEQAWLCEQEDVQAIVRNLARQNC 108
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 6-112 7.02e-63

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 186.95  E-value: 7.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578215912   6 TMIKPIQLFKILGDETRLAIIMLLRESGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPHMPAWA 85
Cdd:PRK10141   2 SFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81

                         90       100
                 ....*....|....*....|....*..
gi 578215912  86 AEIIATTRQSMREDIDEWRKKTACATC 112
Cdd:PRK10141  82 AKIIEQAWLCEQEDVQAIVRNLARQNC 108
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-85 3.71e-31

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 105.23  E-value: 3.71e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578215912  12 QLFKILGDETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPHMPAWA 85
Cdd:NF033788   3 ELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-90 8.92e-30

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 102.28  E-value: 8.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578215912   1 MIIWSTMIKPIQLFKILGDETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPH 80
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADE 79

                         90
                 ....*....|
gi 578215912  81 MPAWAAEIIA 90
Cdd:COG0640   80 ALAELLEWLL 89
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-79 2.04e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 80.42  E-value: 2.04e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578215912  14 FKILGDETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSP 79
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-80 2.06e-19

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 74.94  E-value: 2.06e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578215912    25 IIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPH 80
Cdd:smart00418   2 ILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 19-64 1.14e-15

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 65.16  E-value: 1.14e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578215912   19 DETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELV 64
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 6-112 7.02e-63

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 186.95  E-value: 7.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578215912   6 TMIKPIQLFKILGDETRLAIIMLLRESGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPHMPAWA 85
Cdd:PRK10141   2 SFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81

                         90       100
                 ....*....|....*....|....*..
gi 578215912  86 AEIIATTRQSMREDIDEWRKKTACATC 112
Cdd:PRK10141  82 AKIIEQAWLCEQEDVQAIVRNLARQNC 108
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 12-85 3.71e-31

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 105.23  E-value: 3.71e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578215912  12 QLFKILGDETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPHMPAWA 85
Cdd:NF033788   3 ELFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAEL 75
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-90 8.92e-30

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 102.28  E-value: 8.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578215912   1 MIIWSTMIKPIQLFKILGDETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPH 80
Cdd:COG0640    1 MSETKELEELAELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADE 79

                         90
                 ....*....|
gi 578215912  81 MPAWAAEIIA 90
Cdd:COG0640   80 ALAELLEWLL 89
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-79 2.04e-21

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 80.42  E-value: 2.04e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578215912  14 FKILGDETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSP 79
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-80 2.06e-19

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 74.94  E-value: 2.06e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578215912    25 IIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSPH 80
Cdd:smart00418   2 ILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 19-64 1.14e-15

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 65.16  E-value: 1.14e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578215912   19 DETRLAIIMLLREsGELCVCDLCAATGQSQPKISRHMAILRESELV 64
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 12-71 1.73e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.15  E-value: 1.73e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578215912   12 QLFKILGDETRLAIIMLLRESGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGK 71
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-79 1.89e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 49.11  E-value: 1.89e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578215912  12 QLFKILGDETRLAIIMLLRESGELCVCDLCAATGQSQPKISRHMAILRESELVLDRRQGKWVHYRLSP 79
Cdd:COG3398   89 KILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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