|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
9-460 |
0e+00 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 737.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 9 RDALSWLLTGTVVLLVLLFSAMIVRDYGRETAAARQNIEEKGSVLIRALESGTRVGMGMRMHHAQLQALLEEMAWQPGVL 88
Cdd:PRK10364 9 AKWLSALLPVVIVGLVGLFSVTVIRDYGRETAAARQTLLEKGSVLIRALESGSRVGMGMRMHHAQQQALLEEMAGQPGVR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 89 WFAVTDENGKIIAHSDPQQVDTALYSPAQMRELKVGEQERWRRL--AEPQPALEIYRQFRPLNPARGHHMGMMKRCNSal 166
Cdd:PRK10364 89 WFAVTDEQGTIVAHSNPGMVGKQLYSPQEMQQLHPGDEEAWRRIdsADGEPVLEIYRQFQPMFAAGMHGMRHMQQYAA-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 167 aqPNVPQVIFIAFDSRELDAAQARGLRNMMIMLVAAALVIVATILAQFWFRRYRRSRQQLQEAMARKEKLMALGHLAAGV 246
Cdd:PRK10364 167 --ANTPQAIFIAFDASNLVSAQAREQRNTLIILFALATVLLASLLAFFWYRRYLRSRQLLQDEMKRKEKLVALGHLAAGV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 247 AHEIRNPLSSIKGLAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVRPAHLNYQPVDINALIHHSLQLVSQDA 326
Cdd:PRK10364 245 AHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 327 QSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRqRVKIVVKDSGKGMSDEELQAIFTP 406
Cdd:PRK10364 325 NSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA-GVKISVTDSGKGIAADQLEAIFTP 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 578218272 407 YFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQRREDEQ 460
Cdd:PRK10364 404 YFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDPQG 457
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
223-458 |
1.28e-86 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 269.41 E-value: 1.28e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPGgEAQELALVMAKEADRLNRVVSELLELVRPA 302
Cdd:COG3852 119 RKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDD-ELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 303 HLNYQPVDINALIHHSLQLVSQDAQsRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEA--- 379
Cdd:COG3852 198 PPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqv 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 380 ------DRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDA 453
Cdd:COG3852 277 tlgglrPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
|
....*
gi 578218272 454 QRRED 458
Cdd:COG3852 357 AEEEP 361
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
217-451 |
7.21e-79 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 249.33 E-value: 7.21e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 217 RRYRRSRQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKG---LAKYFAERTPPGGEAQELALVMAKEADRLNRVVS 293
Cdd:COG4191 120 ERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGnaeLLRRRLEDEPDPEELREALERILEGAERAAEIVR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 294 ELLELVRPAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAI--GRDGV 371
Cdd:COG4191 200 SLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMeeGEGGR 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 372 IHVSASEADRQrVKIVVKDSGKGMSDEELQAIFTPYFTTKA--DGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWL 449
Cdd:COG4191 280 ITISTRREGDY-VVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
..
gi 578218272 450 PV 451
Cdd:COG4191 359 PL 360
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
223-454 |
1.41e-76 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 250.66 E-value: 1.41e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKyFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVRPA 302
Cdd:PRK11360 374 RKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQ-IWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 303 HLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRQ 382
Cdd:PRK11360 453 ESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDG 532
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578218272 383 RVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQ 454
Cdd:PRK11360 533 QVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
229-455 |
3.54e-76 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 244.49 E-value: 3.54e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 229 AMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPGGEA-----QELALVMAKEADRLNRVVSELLELVRPAH 303
Cdd:COG5000 191 ELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEdredlERALDTIIRQVDRLKRIVDEFLDFARLPE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 304 LNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASeADRQR 383
Cdd:COG5000 271 PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTR-REDGR 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578218272 384 VKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQR 455
Cdd:COG5000 350 VRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
223-460 |
5.86e-68 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 224.85 E-value: 5.86e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKYFAERTppgGEAQELAL-VMAKEADRLNRVVSELLELVRP 301
Cdd:COG5809 254 RKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTI---DEEQKTYLdIMLSELDRIESIISEFLVLAKP 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 302 AHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADR 381
Cdd:COG5809 331 QAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDD 410
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578218272 382 QRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQRREDEQ 460
Cdd:COG5809 411 DKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVSMN 489
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
173-451 |
1.04e-63 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 208.99 E-value: 1.04e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 173 QVIFIAFDSRELDAAQARGLRNMMIMLVAAALVIVATILAQFWFRRYRRSRQQLQEAMARKeklmalGHLAAGVAHEIRN 252
Cdd:COG0642 50 LLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAK------SRFLANVSHELRT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 253 PLSSIKGLAKYFAERTPPggEAQELALVMAKEADRLNRVVSELLELVR----PAHLNYQPVDINALIHHSLQLVSQDAQS 328
Cdd:COG0642 124 PLTAIRGYLELLLEELDE--EQREYLETILRSADRLLRLINDLLDLSRleagKLELEPEPVDLAELLEEVVELFRPLAEE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 329 RGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEaDRQRVKIVVKDSGKGMSDEELQAIFTPYF 408
Cdd:COG0642 202 KGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR-EGDRVRISVEDTGPGIPPEDLERIFEPFF 280
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 578218272 409 TTKAD----GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:COG0642 281 RTDPSrrggGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
199-451 |
2.06e-63 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 210.88 E-value: 2.06e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 199 LVAAALVIVATILAQFWFRRYRRSRQQLQEaMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQELA 278
Cdd:COG5806 162 LYFIIIQLLAMLIAVYLIENLIENILLRKE-LQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYI 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 279 LVMAKEADRLNRVVSELLELVRPAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTsIKADPDRLNQVLLNL 358
Cdd:COG5806 241 RIALEELDRAEAIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLY-IEGDRQKLQQCLINI 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 359 YLNAMQAIGRDGVIHVSASEADRQrVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQ 438
Cdd:COG5806 320 IKNGIEAMPNGGTLTIDVSIDKNK-VIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESE 398
|
250
....*....|...
gi 578218272 439 PGAGAIFTLWLPV 451
Cdd:COG5806 399 VGKGTTFTITLPL 411
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
220-454 |
5.48e-62 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 201.29 E-value: 5.48e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 220 RRSRQQLQEAMARKEKLMAlghlaaGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQ-ELALVMAKEADRLNRVVSELLEL 298
Cdd:COG2205 3 EEALEELEELERLKSEFLA------NVSHELRTPLTSILGAAELLLDEEDLSPEERrELLEIIRESAERLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 299 VR----PAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHV 374
Cdd:COG2205 77 SRlesgKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 375 SASEADrQRVKIVVKDSGKGMSDEELQAIFTPYF----TTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:COG2205 157 SARREG-DGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
....
gi 578218272 451 VDAQ 454
Cdd:COG2205 236 LAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
201-454 |
5.99e-61 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 203.63 E-value: 5.99e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 201 AAALVIVATILAQFWFRRYRRSRQQLQEAMARKEklmalgHLAAGVAHEIRNPLSSIKG---LAKYFAERTPPggEAQEL 277
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVERDITELERLEQMRR------EFVANVSHELRTPLTSIRGyleLLLDGAADDPE--ERREY 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 278 ALVMAKEADRLNRVVSELLELVR----PAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQ 353
Cdd:COG5002 205 LEIILEEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 354 VLLNLYLNAMQAIGRDGVIHVSASEADrQRVKIVVKDSGKGMSDEELQAIFTPYFTT------KADGTGLGLAVVQNIIE 427
Cdd:COG5002 285 VLTNLLDNAIKYTPEGGTITVSLREED-DQVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLAIVKHIVE 363
|
250 260
....*....|....*....|....*..
gi 578218272 428 QHGGTIRAESQPGAGAIFTLWLPVDAQ 454
Cdd:COG5002 364 AHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
223-452 |
8.22e-59 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 196.93 E-value: 8.22e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKyFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVRPA 302
Cdd:COG5807 131 RKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQ-LLQESREDSEREEYFNIIISEIDRINTIITELLVLSKPK 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 303 HLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRQ 382
Cdd:COG5807 210 KFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDF 289
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 383 rVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVD 452
Cdd:COG5807 290 -VVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPLY 358
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
223-451 |
1.52e-56 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 194.95 E-value: 1.52e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGlakyFAERTPPGGEAQE-LALVMAKEADRLNRVVSELLELVRP 301
Cdd:COG5805 271 KKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKG----FLQLLQPGIEDKEeYFDIMLSELDRIESIISEFLALAKP 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 302 AHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADr 381
Cdd:COG5805 347 QAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEED- 425
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 382 QRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:COG5805 426 NSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
210-454 |
5.45e-54 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 186.88 E-value: 5.45e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 210 ILAQFW-FRRYRRSRQQLQEAMARKEKLmaLGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPgGEAQELALVMAKEADRL 288
Cdd:COG5808 213 LLLQYNlLKRKTLLERVIQEINTQKLEL--IGTFAASTAHEIRNPLTSIKGFIQLLQEKYPE-LEDQKYFDIIQEEIQRI 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 289 NRVVSELLELVRPAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGR 368
Cdd:COG5808 290 NQIVSEFLVLGKPTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 369 DGVIHVSAsEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLW 448
Cdd:COG5808 370 GGKLTISI-ENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIR 448
|
....*.
gi 578218272 449 LPVDAQ 454
Cdd:COG5808 449 LPLKKE 454
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
217-454 |
1.89e-41 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 157.53 E-value: 1.89e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 217 RRYRRSRQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELL 296
Cdd:PRK13837 428 RRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQIL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 297 ELVRPAHLNYQPVDINALIHHSLQLVSQdAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSA 376
Cdd:PRK13837 508 AFGRKGERNTKPFDLSELVTEIAPLLRV-SLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISL 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 377 SEADRQRVK--------------IVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAG 442
Cdd:PRK13837 587 SRAKLRAPKvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRG 666
|
250
....*....|..
gi 578218272 443 AIFTLWLPVDAQ 454
Cdd:PRK13837 667 TRFDVYLPPSSK 678
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-454 |
1.87e-38 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 146.08 E-value: 1.87e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 1 MLRITSCFRDALSWLLTGTVVLLVLLFSAMIVRDYGRETAAARQNIEEKGSVLIRALESGTRVGMGMRMHHAQLQALLEE 80
Cdd:COG4251 45 LLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 81 MAWQPGVLWFAVTDE-NGKIIAHSDPQQVDTALYSPAQMRELKVGEQERWRRLAEPQPALEIYRQFRPLNPARGHHMGMM 159
Cdd:COG4251 125 LLLLLLLLALLLLEElALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 160 KRCNSALAQPNVPQVIFIAFDSRELDAAQARGLRNMMIMLVAAALVIVATILAQFWFRRYRRSRQQLQEAMARKEKlmAL 239
Cdd:COG4251 205 LLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNE--EL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 240 GHLAAGVAHEIRNPLSSIKGLAKYFAERTPP--GGEAQELALVMAKEADRLNRVVSELLELVR--PAHLNYQPVDINALI 315
Cdd:COG4251 283 EQFAYVASHDLREPLRKISGFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELL 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 316 HHSLQLVSQDAQSRGIELQFTPRPEltsIKADPDRLNQVLLNLYLNAM--QAIGRDGVIHVSASEADRQrVKIVVKDSGK 393
Cdd:COG4251 363 EEVLEDLEPRIEERGAEIEVGPLPT---VRGDPTLLRQVFQNLISNAIkySRPGEPPRIEIGAEREGGE-WVFSVRDNGI 438
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578218272 394 GMSDEELQAIFTPYFT----TKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQ 454
Cdd:COG4251 439 GIDPEYAEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-451 |
1.32e-36 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 130.23 E-value: 1.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 348 PDRLNQVLLNLYLNAMQAIGRDGVIHVSASeADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTK--ADGTGLGLAVVQNI 425
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTW-AHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRI 79
|
90 100
....*....|....*....|....*.
gi 578218272 426 IEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:cd16943 80 IQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
346-451 |
7.24e-35 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 125.84 E-value: 7.24e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 346 ADPDRLNQVLLNLYLNAMQAIGRDGVIHVSAsEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKAD-----GTGLGLA 420
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTL-ERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 578218272 421 VVQNIIEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
221-454 |
4.28e-31 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 123.42 E-value: 4.28e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 221 RSRQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKyfaertppGGEAQELALVMAKEADRLNRVVSELLELVr 300
Cdd:COG3290 171 RDRTELERLEEELEGVKELAEALRAQRHDFRNHLHTISGLLQ--------LGEYDEALEYIDEISEELQELIDSLLSRI- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 301 pahlnyQPVDINALIHHslqlVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAI----GRDGVIHVSA 376
Cdd:COG3290 242 ------GNPVLAALLLG----KAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpEEERRVELSI 311
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578218272 377 SEaDRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKA-DGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQ 454
Cdd:COG3290 312 RD-DGDELVIEVEDSGPGIPEELLEKIFERGFSTKLgEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
351-449 |
2.02e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 113.47 E-value: 2.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRDGVIHVSAsEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKAD----GTGLGLAVVQNII 426
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISL-RQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSreggGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 578218272 427 EQHGGTIRAESQPGAGAIFTLWL 449
Cdd:cd00075 80 EAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
346-452 |
5.07e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 112.46 E-value: 5.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 346 ADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRqrVKIVVKDSGKGMSDEELQAIFTPYFT---TKADGTGLGLAVV 422
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE--LTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|
gi 578218272 423 QNIIEQHGGTIRAESQPGAGAIFTLWLPVD 452
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
220-451 |
5.58e-29 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 116.72 E-value: 5.58e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 220 RRSRQQLQEA--MARKEklmalghLAAGVAHEIRNPLSSIKGLAKYFaERTPPGGEAQELALVMAKEADRLNRVVSELLE 297
Cdd:PRK11073 116 RLSQEQLQHAqqVAARD-------LVRGLAHEIKNPLGGLRGAAQLL-SKALPDPALTEYTKVIIEQADRLRNLVDRLLG 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 298 LVRPAhlNYQPVDINALIHHSLQLVSQDAQSrGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIG-RDGVIHVSA 376
Cdd:PRK11073 188 PQRPG--THVTESIHKVAERVVQLVSLELPD-NVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGpEGGTITLRT 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 377 SEA-------DRQRV--KIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAgAIFTL 447
Cdd:PRK11073 265 RTAfqltlhgERYRLaaRIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSV 343
|
....
gi 578218272 448 WLPV 451
Cdd:PRK11073 344 YLPI 347
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
184-453 |
3.57e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 116.48 E-value: 3.57e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 184 LDAAQARGLRNMMIMLVAAALVIVATILAQFW-FRRYRRSRQQLQE-------AMARKEklmaLGHLAAGV--------- 246
Cdd:PRK11100 177 IKRSERRILWAGALLLGIALLIGAGVVWWLNRsIRRLTRYADAVTEgkpvplpKLGSSE----LRELAQALesmrvkleg 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 247 -----------AHEIRNPLSSIKGLAKYFAErTPPGGEAQELALVMAKEADRLNRVVSELLELV----RPAHLNYQPVDI 311
Cdd:PRK11100 253 kayveqyvqtlTHELKSPLAAIRGAAELLQE-DPPPEDRARFTGNILTQSARLQQLIDRLLELArleqRQELEVLEPVAL 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 312 NALIHHSLQLVSQDAQSRGIELQFtpRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSAsEADRQRVKIVVKDS 391
Cdd:PRK11100 332 AALLEELVEAREAQAAAKGITLRL--RPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSA-EVDGEQVALSVEDQ 408
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578218272 392 GKGMSDEELQAIF-----TPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDA 453
Cdd:PRK11100 409 GPGIPDYALPRIFerfysLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
218-451 |
1.92e-27 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 112.74 E-value: 1.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 218 RYRRSRQQLQEAMARKEKLMALghlaagVAHEIRNPLS-------SIKGLAKYFAERTPPGGEAQeLALVMAKEADRLNR 290
Cdd:PRK09303 136 VLRQENETLLEQLKFKDRVLAM------LAHDLRTPLTaaslaleTLELGQIDEDTELKPALIEQ-LQDQARRQLEEIER 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 291 VVSELLELVRPA----HLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAI 366
Cdd:PRK09303 209 LITDLLEVGRTRwealRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYT 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 367 GRDGVIHVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKAD----GTGLGLAVVQNIIEQHGGTIRAESQPGAG 442
Cdd:PRK09303 289 PEGGTITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDegteGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
|
....*....
gi 578218272 443 AIFTLWLPV 451
Cdd:PRK09303 369 SCFHFTLPV 377
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
216-450 |
6.40e-27 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 112.72 E-value: 6.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 216 FRRYRRSRQQLQEAMARkeklMALGH--LAAGVAHEIRNPLSSIKgLAKYFAERTppGGEAQELALVmAKEADRLNRVVS 293
Cdd:PRK09470 222 FRQAGASFNQMVTALER----MMTSQqrLLSDISHELRTPLTRLQ-LATALLRRR--QGESKELERI-ETEAQRLDSMIN 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 294 ELLELVR---PAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMqaigRDG 370
Cdd:PRK09470 294 DLLVLSRnqqKNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNAL----RYS 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 371 VIHVSAS-EADRQRVKIVVKDSGKGMSDEELQAIFTPYFTT------KADGTGLGLAVVQNIIEQHGGTIRAESQPGAGA 443
Cdd:PRK09470 370 HTKIEVAfSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGL 449
|
....*..
gi 578218272 444 IFTLWLP 450
Cdd:PRK09470 450 RLTIWLP 456
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
2.07e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 102.47 E-value: 2.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLN---AMQAIGRDG-VIHVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNII 426
Cdd:cd16920 1 IQQVLINLVRNgieAMSEGGCERrELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 578218272 427 EQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
244-454 |
1.41e-24 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 105.87 E-value: 1.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 244 AGVAHEIRNPLSSIKGLAKYFAE--RTPpggEAQELALVMAkEADRLNRVVSEL--LELVRPAHLNYQ--PVDINALIHH 317
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIQDgvRKF---TPESVASLQA-EVGTLTKLVDDLhqLSLSDEGALAYRktPVDLVPLLEV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 318 SLQLVSQDAQSRGIELQfTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSAsEADRQRVKIVVKDSGKGMSD 397
Cdd:PRK10549 321 AGGAFRERFASRGLTLQ-LSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISA-EQRDKTLRLTFADSAPGVSD 398
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578218272 398 EELQAIFTPYFTTKAD------GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDAQ 454
Cdd:PRK10549 399 EQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-450 |
6.96e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 95.68 E-value: 6.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 347 DPDRLNQVLLNLYLNAMQAI-GR-DGVIHVSA-SEADR-QRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVV 422
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIeGRpSDVGEVRIrVEADQdGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80
|
90 100
....*....|....*....|....*...
gi 578218272 423 QNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
351-451 |
3.94e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 93.71 E-value: 3.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRDGV---IHVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPY------FTTKADGTGLGLAV 421
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVtlrVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 578218272 422 VQNIIEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
223-460 |
1.40e-22 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 100.52 E-value: 1.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGLAKYF---AERTPPGGEAQELALVMAKEA-DRLNRVVSELLEL 298
Cdd:PRK13557 147 RRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIqaaLSHPDADRGRMARSVENIRAAaERAATLTQQLLAF 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 299 VRPAHLNYQPVDINALIHHSLQLVSQdAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSA-- 376
Cdd:PRK13557 227 ARKQRLEGRVLNLNGLVSGMGELAER-TLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTrn 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 377 SEADRQR------------VKIVVKDSGKGMSDEELQAIFTPYFTTKADG--TGLGLAVVQNIIEQHGGTIRAESQPGAG 442
Cdd:PRK13557 306 VEIEDEDlamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEEGkgTGLGLSMVYGFAKQSGGAVRIYSEVGEG 385
|
250
....*....|....*...
gi 578218272 443 AIFTLWLPVDAQRREDEQ 460
Cdd:PRK13557 386 TTVRLYFPASDQAENPEQ 403
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-449 |
3.53e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 90.98 E-value: 3.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGR--DGVIHVSASEADrQRVKIVVKDSGKGMSDEELQAIFTPYFTTK--ADGTGLGLAVVQNII 426
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLG-GRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 578218272 427 EQHGGTIRAESQPGAGAIFTLWL 449
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
1.21e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 89.38 E-value: 1.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAI-GRDGVIHVSASEA-------DRQRV--KIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLA 420
Cdd:cd16918 1 LIQVFLNLVRNAAQALaGSGGEIILRTRTQrqvtlghPRHRLalRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 578218272 421 VVQNIIEQHGGTIRAESQPGAgAIFTLWLP 450
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
351-450 |
1.26e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 89.75 E-value: 1.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRDGVIHVSASEADR--------------QRVKIVVKDSGKGMSDEELQAIFTPYFTTK--ADG 414
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQRVdadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKevGKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 578218272 415 TGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
223-450 |
2.19e-21 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 97.06 E-value: 2.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 223 RQQLQEAMARKEKLMALGHLAAGVAHEIRNPLSSIKGL---AKYFAERTPPGgEAQELALVMAKEADRLNRVVSELLELV 299
Cdd:COG4192 417 LRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYlfsAKKALEQENYA-QLPTSLDKIEGLIERMDKIIKSLRQFS 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 300 RPAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFtprPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEA 379
Cdd:COG4192 496 RKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHI---PDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSN 572
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578218272 380 DRqRVKIVVKDSGKGMSDeeLQAIFTPYFTTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:COG4192 573 AE-NLRVAISDNGNGWPL--VDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
237-452 |
2.23e-21 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 97.50 E-value: 2.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 237 MALGHLAAGVAHEIRNPLSSIKGlakyFAERTPPGGEAQE-----LALVMAKEADRLNrVVSELLELVRPAHLNYQ--P- 308
Cdd:PRK09959 710 VAKSQFLATMSHEIRTPISSIMG----FLELLSGSGLSKEqrveaISLAYATGQSLLG-LIGEILDVDKIESGNYQlqPq 784
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 309 -VDINALIHHSLQLVSQDAQSRGIELQFTPR-PELTSIKADPDRLNQVLLNLYLNAMQaIGRDGVIHVSAS----EADRQ 382
Cdd:PRK09959 785 wVDIPTLVQNTCHSFGAIAASKSIALSCSSTfPDHYLVKIDPQAFKQVLSNLLSNALK-FTTEGAVKITTSlghiDDNHA 863
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578218272 383 RVKIVVKDSGKGMSDEELQAIFTPYFTTKA----DGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVD 452
Cdd:PRK09959 864 VIKMTIMDSGSGLSQEEQQQLFKRYSQTSAgrqqTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
242-453 |
1.42e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.44 E-value: 1.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 242 LAAGVAHEIRNPLSSIKgLAkyfAERTPPggEAQELALVMAKEADRLNRVVSELLELVRP-AHLNYQPVDINALIHHSLQ 320
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIR-LA---TEMMSE--EDGYLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVIA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 321 lvSQDAQSRGIELQFTPRPelTSIKADPDRLNQVLLNLYLNAMQaIGRdGVIHVSaSEADRQRVKIVVKDSGKGMSDEEL 400
Cdd:PRK09467 306 --AESGYEREIETALQPGP--IEVPMNPIAIKRALANLVVNAAR-YGN-GWIKVS-SGTEGKRAWFQVEDDGPGIPPEQL 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 578218272 401 QAIFTPYftTKAD------GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDA 453
Cdd:PRK09467 379 KHLFQPF--TRGDsargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-450 |
1.80e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 86.36 E-value: 1.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 347 DPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADrQRVKIVVKDSGKGMSDEELQAIFTPYFTTK------ADGTGLGLA 420
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTP-QEVRLDVEDSAPGVSDDQLARLFERFYRVEssrnraSGGSGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 578218272 421 VVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16946 80 ICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
3.95e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 85.07 E-value: 3.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAigRDGVIHVSASEADRQrVKIVVKDSGKGMSDEELQAIFTPYF------TTKADGTGLGLAVVQN 424
Cdd:cd16949 1 LARALENVLRNALRY--SPSKILLDISQDGDQ-WTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAER 77
|
90 100
....*....|....*....|....*.
gi 578218272 425 IIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
222-453 |
4.70e-20 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 93.08 E-value: 4.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 222 SRQQLQEAM--ARKEKlmalGHLAAGVAHEIRNPLSSIKGLAKYFAErTPPGGEAQELALVMAKEADRLNRVVSELLEL- 298
Cdd:PRK11091 268 ERKRYQDALekASRDK----TTFISTISHELRTPLNGIVGLSRILLD-TELTAEQRKYLKTIHVSAITLGNIFNDIIDMd 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 299 ---VRPAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPELTS-IKADPDRLNQVLLNLYLNAMQaIGRDGVIHV 374
Cdd:PRK11091 343 kmeRRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHkVITDGTRLRQILWNLISNAVK-FTQQGGVTV 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 375 SASEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTK-------ADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTL 447
Cdd:PRK11091 422 RVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKdshggkpATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
|
....*.
gi 578218272 448 WLPVDA 453
Cdd:PRK11091 502 TIHAPA 507
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
239-440 |
5.74e-20 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 92.07 E-value: 5.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 239 LGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVRPAHLNYQP----VDINAL 314
Cdd:TIGR01386 241 LSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALervrLDLAAE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 315 IHHSLQLVSQDAQSRGIELQFTPRPELtsiKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEaDRQRVKIVVKDSGKG 394
Cdd:TIGR01386 321 LAKVAEYFEPLAEERGVRIRVEGEGLV---RGDPQMFRRAISNLLSNALRHTPDGGTITVRIER-RSDEVRVSVSNPGPG 396
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 578218272 395 MSDEELQAIFTPYF------TTKADGTGLGLAVVQNIIEQHGGTIRAESQPG 440
Cdd:TIGR01386 397 IPPEHLSRLFDRFYrvdparSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG 448
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
221-453 |
1.64e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 91.63 E-value: 1.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 221 RSRQQLQEAMARKEKlmalgHLAAgVAHEIRNPLSSIKGlAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVR 300
Cdd:PRK15347 386 EAKQRAEQANKRKSE-----HLTT-ISHEIRTPLNGVLG-ALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSR 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 301 ----PAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPEL-TSIKADPDRLNQVLLNLYLNAMQaIGRDGVIHVS 375
Cdd:PRK15347 459 iesgQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVpLYLHLDSLRLRQILVNLLGNAVK-FTETGGIRLR 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 376 ASEADrQRVKIVVKDSGKGMSDEELQAIFTPYFTT--KADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDA 453
Cdd:PRK15347 538 VKRHE-QQLCFTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNE 616
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
347-450 |
1.97e-19 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 83.31 E-value: 1.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 347 DPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPY------FTTKADGTGLGLA 420
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 578218272 421 VVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
202-451 |
4.13e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 87.27 E-value: 4.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 202 AALVIVATILAQFWFRRYRRSRQQLQEAMARKEKLMAlghlaaGVAHEIRNPLSSIKGLAKYFAERtPPGGEAQELALVM 281
Cdd:PRK11466 413 AAQVKARTAELQELVIEHRQARAEAEKASQAKSAFLA------AMSHEIRTPLYGILGTAQLLADN-PALNAQRDDLRAI 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 282 AKEADRLNRVVSELLELV------RPAHLNYQPVDINALIHHSLQLVSQDAQSRGIELQFTPRPEL-TSIKADPDRLNQV 354
Cdd:PRK11466 486 TDSGESLLTILNDILDYSaieaggKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLpTALMGDPRRIRQV 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 355 LLNLYLNAMQAIGRdGVIHVSaSEADRQRVKIVVKDSGKGMSDEELQAIFTPY--FTTKADGTGLGLAVVQNIIEQHGGT 432
Cdd:PRK11466 566 ITNLLSNALRFTDE-GSIVLR-SRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGE 643
|
250
....*....|....*....
gi 578218272 433 IRAESQPGAGAIFTLWLPV 451
Cdd:PRK11466 644 LSATSTPEVGSCFCLRLPL 662
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
242-453 |
5.15e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 83.93 E-value: 5.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 242 LAAGVAHEIRNPLSSIKGLAKYF-----AERTPPGGEAQELalvmakEADRLN--RVVSELLELVRPA----HLNYQPVD 310
Cdd:PRK10490 667 LLAALSHDLRTPLTVLFGQAEILtldlaSEGSPHARQASEI------RQQVLNttRLVNNLLDMARIQsggfNLRKEWLT 740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 311 INALIHHSLQLVSQDAQSRGIELQFTPrpELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADrQRVKIVVKD 390
Cdd:PRK10490 741 LEEVVGSALQMLEPGLSGHPINLSLPE--PLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEG-ERLQLDVWD 817
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578218272 391 SGKGMSDEELQAIFTPYftTKAD------GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDA 453
Cdd:PRK10490 818 NGPGIPPGQEQLIFDKF--ARGNkesaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLET 884
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
2.47e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 74.29 E-value: 2.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRD--GVIHVSASE-ADRQRvkIVVKDSGKGMSDEELQAIFTPYFTTKAD----GTGLGLAVVQ 423
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDvGEEWT--FYVRDNGIGIDPEYAEKVFGIFQRLHSReeyeGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 578218272 424 NIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
243-450 |
3.24e-16 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 80.59 E-value: 3.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 243 AAGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVRP----AHLNYQPVDINALIHHS 318
Cdd:PRK09835 266 SADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQAdnnqLIPEKKMLDLADEVGKV 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 319 LQLVSQDAQSRGIELQFTPRPELtsIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRQrVKIVVKDSGKGMSDE 398
Cdd:PRK09835 346 FDFFEAWAEERGVELRFVGDPCQ--VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQ-VQLVVENPGTPIAPE 422
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 578218272 399 ELQAIFTPYFTT------KADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAiFTLWLP 450
Cdd:PRK09835 423 HLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTR-FVISLP 479
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-450 |
3.29e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 74.25 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 357 NLYLNAMQAIGRDGV----IHVSASEaDRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGT-GLGLAVVQNIIEQHGG 431
Cdd:cd16915 7 NLIDNALDALAATGApnkqVEVFLRD-EGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGG 85
|
90
....*....|....*....
gi 578218272 432 TIRAESQPGAGAIFTLWLP 450
Cdd:cd16915 86 SITVESEPGGGTTFSIRIP 104
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
354-456 |
7.19e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 79.96 E-value: 7.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 354 VLLNLYLNAMQAIGR--DGVIHVSASEADRQrVKIVVKDSGKGMSDEELQAIFTPYFTTKADGTGLGLAVVQNIIEQHGG 431
Cdd:PRK11086 437 ILGNLIENALEAVGGeeGGEISVSLHYRNGW-LHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGG 515
|
90 100
....*....|....*....|....*
gi 578218272 432 TIRAESQPGAGAIFTLWLPVDAQRR 456
Cdd:PRK11086 516 SIAVESEPGVGTQFFVQIPWDGERS 540
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
245-451 |
3.10e-14 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 74.25 E-value: 3.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 245 GVAHEIRNPLSSIKglakYFAERTPPGGEAQELALvmAKEADRLNRVVSELL---ELVRP-AHLNYQPVDINALIHHSLQ 320
Cdd:PRK10604 218 GIAHELRTPLVRLR----YRLEMSDNLSAAESQAL--NRDIGQLEALIEELLtyaRLDRPqNELHLSEPDLPAWLSTHLA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 321 LVSQDAQSRGIELQFTPRPELtsIKADPDRLNQVLLNLYLNAMQAIGrdGVIHVSASeADRQRVKIVVKDSGKGMSDEEL 400
Cdd:PRK10604 292 DIQAVTPEKTVRLDTPHQGDY--GALDMRLMERVLDNLLNNALRYAH--SRVRVSLL-LDGNQACLIVEDDGPGIPPEER 366
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 578218272 401 QAIFTPYF------TTKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:PRK10604 367 ERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
244-450 |
3.71e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 73.89 E-value: 3.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 244 AGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVR----PAHLNYQPVDINALihhsL 319
Cdd:PRK11006 209 ANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKieaaPTIDLNEKVDVPMM----L 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 320 QLVSQDAQS---RGIELQFTPRPELtSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADrQRVKIVVKDSGKGMS 396
Cdd:PRK11006 285 RVLEREAQTlsqGKHTITFEVDNSL-KVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVP-QGAEFSVEDNGPGIA 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578218272 397 DEELQAI---FtpYFTTKA-----DGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:PRK11006 363 PEHIPRLterF--YRVDKArsrqtGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-449 |
7.66e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 67.82 E-value: 7.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 347 DPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRQRVKivVKDSGKGMSDEELQAIFTPYF---TTKADGTGLGLAVVQ 423
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIR--VEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVK 87
|
90 100
....*....|....*....|....*.
gi 578218272 424 NIIEQHGGTIRAESQPGAGAIFTLWL 449
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-449 |
1.69e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.15 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 346 ADPDRLNQVLLNLYLNAMQaIGRDGVIHVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKAD------GTGLGL 419
Cdd:cd16947 16 ANTEALQRILKNLISNAIK-YGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSrnsakqGNGLGL 94
|
90 100 110
....*....|....*....|....*....|
gi 578218272 420 AVVQNIIEQHGGTIRAESQPGAGAIFTLWL 449
Cdd:cd16947 95 TITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
2.26e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 65.93 E-value: 2.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGrdGVIHVSaSEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKA----DGTGLGLAVVQNII 426
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVS-SDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRIS 77
|
90 100
....*....|....*....|....
gi 578218272 427 EQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16950 78 DAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
224-450 |
1.51e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 70.00 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 224 QQLQEaMAR------KEKLMALghlaAGVAHEIRNPLSSIKGLAKYFAERTPPGGeAQELALVMAKEADRLNRVVSELLE 297
Cdd:PRK10841 431 ESLQE-MAQaaeqasQSKSMFL----ATVSHELRTPLYGIIGNLDLLQTKELPKG-VDRLVTAMNNSSSLLLKIISDILD 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 298 L---------VRPAHLNYQPVdINALIHHSLQLVSqdaqsrgielqftpRPELT-----------SIKADPDRLNQVLLN 357
Cdd:PRK10841 505 FskieseqlkIEPREFSPREV-INHITANYLPLVV--------------KKRLGlycfiepdvpvALNGDPMRLQQVISN 569
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 358 LYLNAMQAIGRDGVI-HVSAseaDRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKA------DGTGLGLAVVQNIIEQHG 430
Cdd:PRK10841 570 LLSNAIKFTDTGCIVlHVRV---DGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrnfQGTGLGLAICEKLINMMD 646
|
250 260
....*....|....*....|
gi 578218272 431 GTIRAESQPGAGAIFTLWLP 450
Cdd:PRK10841 647 GDISVDSEPGMGSQFTIRIP 666
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
236-300 |
3.09e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.46 E-value: 3.09e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578218272 236 LMALGHLAAGVAHEIRNPLSSIKGLAKYFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVR 300
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-445 |
3.95e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 63.42 E-value: 3.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 327 QSRGIELQFTPRPELTsIKADPDRLNQVLLNLYLNAMQ-AIGRdgvIHVSASEADRQrVKIVVKDSGKGMSDEELQAIFT 405
Cdd:cd16954 15 QRKGVSISLDISPELR-FPGERNDLMELLGNLLDNACKwCLEF---VEVTARQTDGG-LHLIVDDDGPGVPESQRSKIFQ 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 578218272 406 PyfTTKAD----GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIF 445
Cdd:cd16954 90 R--GQRLDeqrpGQGLGLAIAKEIVEQYGGELSLSDSPLGGARF 131
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
321-452 |
6.60e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 67.95 E-value: 6.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 321 LVSQDAQSRGIEL--QFTPR-PELTSikADPDRLNQVLLNLYLNAMQAIGRdGVIHVS----ASEADRQRVKIVVKDSGK 393
Cdd:PRK11107 378 LLAHSAHEKGLELtlNIDPDvPDNVI--GDPLRLQQIITNLVGNAIKFTES-GNIDILvelrALSNTKVQLEVQIRDTGI 454
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578218272 394 GMSDEELQAIFTPYftTKAD--------GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVD 452
Cdd:PRK11107 455 GISERQQSQLFQAF--RQADasisrrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLD 519
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-448 |
7.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 61.71 E-value: 7.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 347 DPDRLNQVLLNLYLNAMQAIGRDGVIHVSAsEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKADGT-----GLGLAV 421
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISI-YDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYI 79
|
90 100
....*....|....*....|....*..
gi 578218272 422 VQNIIEQHGGTIRAESQPGAGAIFTLW 448
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
380-450 |
1.17e-11 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 63.37 E-value: 1.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 380 DRQRVK-------IVVKDSGKGMSDEELQA-IFTPYFTTKAD-----GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFT 446
Cdd:cd16916 95 DREKIRekaiergLITADEAATLSDDEVLNlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFT 174
|
....
gi 578218272 447 LWLP 450
Cdd:cd16916 175 IRLP 178
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-449 |
2.12e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 60.55 E-value: 2.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 347 DPDRLNQVLLNLYLNAMQAIGRDGVIHVSAsEADRQRVKIVVKDSGKGMSDEELQAIFTPYFT-----TKADGTGLGLAV 421
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQL-EADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAF 79
|
90 100
....*....|....*....|....*...
gi 578218272 422 VQNIIEQHGGTIRAESQPGaGAIFTLWL 449
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPD-GVLAFLTL 106
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
247-447 |
2.48e-11 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 65.44 E-value: 2.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 247 AHEIRNPLSSIKGLAKyFAERTPPGGEAQELALV-MAKEADRLNRVVSELLELVR---PAHLN-YQPVDINALIHHSLQL 321
Cdd:PRK10337 245 AHELRSPLAALKVQTE-VAQLSDDDPQARKKALLqLHAGIDRATRLVDQLLTLSRldsLDNLQdVAEIPLEDLLQSAVMD 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 322 VSQDAQSRGIELQFTprpeltsIKADP-DRLNQVLL------NLYLNAMQAIGRDGVIHVSASEAdrqrvKIVVKDSGKG 394
Cdd:PRK10337 324 IYHTAQQAGIDVRLT-------LNAHPvIRTGQPLLlsllvrNLLDNAIRYSPQGSVVDVTLNAR-----NFTVRDNGPG 391
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 578218272 395 MSDEELQAIFTPYFT---TKADGTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTL 447
Cdd:PRK10337 392 VTPEALARIGERFYRppgQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
238-300 |
3.84e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 58.38 E-value: 3.84e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578218272 238 ALGHLAAGVAHEIRNPLSSIKGLAKyFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVR 300
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLE-LLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-450 |
4.11e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 59.61 E-value: 4.11e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578218272 377 SEADRQRVKIVVKDSGKGMSDEELQAIFTPYFTTKAD-----GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16948 31 SETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGrnfqeSTGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
238-300 |
6.97e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.58 E-value: 6.97e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578218272 238 ALGHLAAGVAHEIRNPLSSIKGLAKyFAERTPPGGEAQELALVMAKEADRLNRVVSELLELVR 300
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLE-LLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
8.21e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 59.12 E-value: 8.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRD-GVIHVSASEADRqRVKIVVKDSGKGMSDEELQAIFTPYFTTKADG------TGLGLAVVQ 423
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGK-MVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 578218272 424 NIIEQHGGTIRAE--SQPG--AGAIFTLWLP 450
Cdd:cd16953 80 QIIEAHGGISVAEnhNQPGqvIGARFTVQLP 110
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
380-451 |
8.68e-11 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 64.05 E-value: 8.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 380 DRQRVK-------IVVKDSGKGMSDEELQA-IFTPYFTTKAD-----GTGLGLAVVQNIIEQHGGTIRAESQPGAGAIFT 446
Cdd:COG0643 334 DLEKIRakaiekgLITAEEAAALSDEELLElIFAPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFT 413
|
....*
gi 578218272 447 LWLPV 451
Cdd:COG0643 414 LRLPL 418
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
1.13e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 58.17 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRDGVIHVSASEADrQRVKIVVKDSGKGMSDEELQAIFTPYF----TTKADGTGLGLAVVQNII 426
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTD-DVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 578218272 427 EQHGGTIRAESQpGAGAIFTLWLP 450
Cdd:cd16923 80 ELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-451 |
3.36e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.05 E-value: 3.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRDGVIhvsASEADRQRVKIVVKDSGKGMSDEELQAIFTPYF------TTKADGTGLGLAVVQN 424
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRI---ALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHR 77
|
90 100
....*....|....*....|....*..
gi 578218272 425 IIEQHGGTIRAESQPGAGAIFTLWLPV 451
Cdd:cd16939 78 VALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
368-451 |
4.91e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 61.19 E-value: 4.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 368 RDGVIHVSASEADrQRVKIVVKDSGKGMSDEELQAIFTPyFTTKADGTGLGLAVVQNIIEQH---GGTIRAESQPGAGAI 444
Cdd:COG2972 358 GGGTIRISIRKEG-DRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTT 435
|
....*..
gi 578218272 445 FTLWLPV 451
Cdd:COG2972 436 VTIRIPL 442
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
197-453 |
8.41e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 59.25 E-value: 8.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 197 IMLVAAALVIVATILAQFWFRRYRRSRQQLQEAMARKEKLMAL----GHLAA----GVAHEirnpLSSIK---GLAKYFA 265
Cdd:COG4585 8 GALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAReeerRRIARelhdGVGQS----LSAIKlqlEAARRLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 266 ERTPPggEAQELALVMAKEADRLNRVVSELLELVRPAHLnyQPVDINALIHhslQLVSQDAQSRGIELQFTPRPELTSIK 345
Cdd:COG4585 84 DADPE--AAREELEEIRELAREALAELRRLVRGLRPPAL--DDLGLAAALE---ELAERLLRAAGIRVELDVDGDPDRLP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 346 ADpdrlnqVLLNLYLNAMQAI------GRDGVIHVSASEADRqRVKIVVKDSGKGMSDEelqaiftpyfttKADGTGLGL 419
Cdd:COG4585 157 PE------VELALYRIVQEALtnalkhAGATRVTVTLEVDDG-ELTLTVRDDGVGFDPE------------AAPGGGLGL 217
|
250 260 270
....*....|....*....|....*....|....
gi 578218272 420 AVVQNIIEQHGGTIRAESQPGAGAIFTLWLPVDA 453
Cdd:COG4585 218 RGMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
243-450 |
6.08e-09 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 57.67 E-value: 6.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 243 AAGVAHEIRNPLSSIKgLAKYFAERTppgGEAQELALVmaKEADRLNRVVSELLELVRP----AHLNYQPVD-INALIHH 317
Cdd:PRK10755 141 TADVAHELRTPLAGIR-LHLELLEKQ---HHIDVAPLI--ARLDQMMHTVEQLLQLARAgqsfSSGHYQTVKlLEDVILP 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 318 SLQLVSQDAQSRGIELQFTPRPELTSIKADPDRLNQVLLNLYLNAMQAIGRDGVIHVSASEADRQrVKIVVKDSGKGMSD 397
Cdd:PRK10755 215 SQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGG-AVLAVEDEGPGIDE 293
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 578218272 398 EELQAIFTPY--FTTKADGTGLGLAVVQNIIEQHGGTIRAES-QPGAGAIFTLWLP 450
Cdd:PRK10755 294 SKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLP 349
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
327-443 |
5.00e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 51.94 E-value: 5.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 327 QSRGIELQFTPRPELTSIKADPDRLnQVLLNLYLNAMQAIGRdgVIHVSASEADrQRVKIVVKDSGKGMSDEELQAIFTP 406
Cdd:PRK10815 356 QRKGVNITLDISPEITFVGEKNDFM-EVMGNVLDNACKYCLE--FVEISARQTD-EHLHIVVEDDGPGIPESKRELIFDR 431
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 578218272 407 yfTTKAD----GTGLGLAVVQNIIEQHGGTIRAESQPGAGA 443
Cdd:PRK10815 432 --GQRADtlrpGQGLGLSVAREITEQYEGKISAGDSPLGGA 470
|
|
| sCache_3_2 |
pfam17203 |
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ... |
37-133 |
1.14e-06 |
|
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435783 [Multi-domain] Cd Length: 140 Bit Score: 47.79 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 37 RETAAARQNIEEKGSVLIRAL--ESGTRVGMGMRMHHAQLQALLEEMAWQPGVLWFAVTDENGKIIAHSDPQQVDTALYS 114
Cdd:pfam17203 1 QLRADLTRQLERRALALARSVaaSPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSG 80
|
90
....*....|....*....
gi 578218272 115 PAQMRELKVGEQerWRRLA 133
Cdd:pfam17203 81 PATAPALTAGRS--YTGTV 97
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
279-450 |
1.34e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 50.60 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 279 LVMAKEADRLNRVV-------SELLELVRPAHLNYQpvdINALIHHSLQlvsqDAQSRGIELQFTPRPELTSIKA--DPD 349
Cdd:PRK15053 359 LLQMKEYDRVLEMVqgesqaqQQLIDSLREAFADRQ---VAGLLFGKVQ----RARELGLKMVIVPGSQLSQLPPglDST 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 350 RLNQVLLNLYLNAMQAIGR----DGVIHVSASEADRQrVKIVVKDSGKGMSDEELQAIFTPYFTTKADGT---GLGLAVV 422
Cdd:PRK15053 432 EFAAIVGNLLDNAFEASLRsdegNKIVELFLSDEGDD-VVIEVADQGCGVPESLRDKIFEQGVSTRADEPgehGIGLYLI 510
|
170 180
....*....|....*....|....*...
gi 578218272 423 QNIIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:PRK15053 511 ASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-450 |
3.19e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 45.66 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 351 LNQVLLNLYLNAMQAIGRDGVIHVSASeADRQRVKIVVKDSGKGMSDEELQAIFTPYF------TTKADGTGLGLAVVQN 424
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWS-QEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKH 79
|
90 100
....*....|....*....|....*.
gi 578218272 425 IIEQHGGTIRAESQPGAGAIFTLWLP 450
Cdd:cd16952 80 VMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
311-447 |
1.11e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 44.87 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 311 INALIHHSLQLvsqdAQSRGIELQFTpRPELTSIKADPDRLNQVLLNLYLNAMQA----IGRDGVIHVSASEADRQRVkI 386
Cdd:cd16935 2 LDSLLSEKLEL----AREKGIEFTIE-IDIPILLPISPLDLCIIFGNLLDNAIEAcakiDKENRFIHLKIRQKKGFLI-I 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578218272 387 VVKDSgkgmSDEELQAIFTPYFTTKAD-GTGLGLAVVQNIIEQHGGTIRAESQPGagaIFTL 447
Cdd:cd16935 76 SIENS----YEGELKKKNGLFLSTKKDkNHGIGLKSIREIVKKYNGNLSIEYENG---IFTL 130
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
367-456 |
5.67e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.28 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 367 GRDGVIHVSASEADRqRVKIVVKDSGKGMSDEelqaiftpyfTTKADGTGLGLAVVQNIIEQHGGTIRAESqpGAGAIFT 446
Cdd:COG3920 419 GEGGRIRVSWRREDG-RLRLTVSDNGVGLPED----------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVR 485
|
90
....*....|
gi 578218272 447 LWLPVDAQRR 456
Cdd:COG3920 486 ITFPLAELAA 495
|
|
| PRK10547 |
PRK10547 |
chemotaxis protein CheA; Provisional |
372-450 |
2.28e-04 |
|
chemotaxis protein CheA; Provisional
Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 43.57 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 372 IHVSASEADRQRVKIVVKDSGKG------MSDEEL-QAIFTPYFTT-----KADGTGLGLAVVQNIIEQHGGTIRAESQP 439
Cdd:PRK10547 432 IEVTDDGAGLNRERILAKAASQGlavsenMSDEEVgMLIFAPGFSTaeqvtDVSGRGVGMDVVKRNIQEMGGHVEIQSKQ 511
|
90
....*....|.
gi 578218272 440 GAGAIFTLWLP 450
Cdd:PRK10547 512 GKGTTIRILLP 522
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-450 |
3.36e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 39.74 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 353 QVLL-NLYLNAMQAIGRDGVIHVSASEADrQRVKIVVKDSGKGMsdeelQAIFTPYFTTKAD-GTGLGLAVV-QNIIEQH 429
Cdd:cd16924 7 QPLVeNAIQHGLSPLTDKGVVTISALKED-NHVMIEVEDNGRGI-----DPKVLNILGKKPKeGNGIGLYNVhQRLILLF 80
|
90 100
....*....|....*....|...
gi 578218272 430 GG--TIRAESQPGAGAIFTLWLP 450
Cdd:cd16924 81 GEdyGIHIASEPDKGTRITFTIP 103
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
211-460 |
7.57e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 42.23 E-value: 7.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 211 LAQfwfRRYRRSRQqlqeamARKEKLMALGHlaagvahEIRNPLSSIKGLAKYFAERTPPGGEAQELALvMAKEADRLNR 290
Cdd:PRK10618 438 QAQ---REYEKNQQ------ARKAFLQNIGD-------ELKQPLQSLAQLAAQLRQTSDEEQQQPELDQ-LAEQSDVLVR 500
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 291 VVSELLELVRPAHLNYQPV----DINALIHHSLQLVSQDAQSRGIEL--QFTPRPELTSIkADPDRLNQVLLNL--YLNA 362
Cdd:PRK10618 501 LVDNIQLLNMLETQDWKPEqelfSLQDLIDEVLPEVLPAIKRKGLQLliHNHLKAEQLRI-GDRDALRKILLLLlnYAIT 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 363 MQAIGRDGVIhVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPYFT-TKAD----GTGLGLAVVQNIIEQHGGTIRAES 437
Cdd:PRK10618 580 TTAYGKITLE-VDQDESSPDRLTIRILDTGAGVSIKELDNLHFPFLNqTQGDrygkASGLTFFLCNQLCRKLGGHLTIKS 658
|
250 260
....*....|....*....|...
gi 578218272 438 QPGAGAIFTLWLPVDAQRREDEQ 460
Cdd:PRK10618 659 REGLGTRYSIHLKMLAADPEVEE 681
|
|
| PRK04778 |
PRK04778 |
septation ring formation regulator EzrA; Provisional |
195-239 |
2.62e-03 |
|
septation ring formation regulator EzrA; Provisional
Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 40.20 E-value: 2.62e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 578218272 195 MMIMLVAAALVIVATILAQFWFRryRRSRQQLQEAMARKEKLMAL 239
Cdd:PRK04778 2 MIYLIIAIVVIIIIAYLAGLILR--KRNYKRIDELEERKQELENL 44
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-440 |
4.87e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 36.67 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578218272 357 NLYLNAMQAIGRDGVIHVSASEADRQRVKIVVKDSGKGMSDEELQAIFTPYFttkaDGTGLGLAVVQN---IIEQHGGTI 433
Cdd:cd16955 12 NAIVHGIQEKKGKGVVKISVKKQLKNRLHIAVEDNGIGISPKVIERVEQDEM----PGNKIGLLNVHQrlkLGYGEGLHI 87
|
....*..
gi 578218272 434 RAESQPG 440
Cdd:cd16955 88 RSRPDPG 94
|
|
| EzrA |
COG4477 |
Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome ... |
195-239 |
6.42e-03 |
|
Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443574 [Multi-domain] Cd Length: 567 Bit Score: 39.06 E-value: 6.42e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 578218272 195 MMIMLVAAALVIVATILAQFWFRryRRSRQQLQEAMARKEKLMAL 239
Cdd:COG4477 1 MMIYIIGIIVLIIALYGAGYIMR--KKHYKEIDRLEERKLEIMNR 43
|
|
| |
