NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578270526|gb|EUM30453|]
View 

allantoate transport membrane protein [Enterobacter sp. BIDMC 26]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 8-217 3.16e-67

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 205.69  E-value: 3.16e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   8 WDIIRNLLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPW 87
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  88 TAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGF 167
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578270526 168 IELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKFNASH 217
Cdd:COG0765  169 PELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 8-217 3.16e-67

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 205.69  E-value: 3.16e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   8 WDIIRNLLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPW 87
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  88 TAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGF 167
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578270526 168 IELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKFNASH 217
Cdd:COG0765  169 PELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
14-214 2.70e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 116.39  E-value: 2.70e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  14 LLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPWTAASLA 93
Cdd:PRK15100  15 LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMIG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  94 LTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKA 173
Cdd:PRK15100  95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQ 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578270526 174 GTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKFN 214
Cdd:PRK15100 175 AQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLN 215
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 14-210 9.33e-26

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 99.54  E-value: 9.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   14 LLLAGRW-TVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPWTAASL 92
Cdd:TIGR03004   6 LLLQGAWvTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   93 ALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTK 172
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 578270526  173 AGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLE 210
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLE 203
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 19-198 4.23e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 59.60  E-value: 4.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  19 RWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLG---IDVSPWTAASLALT 95
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  96 FYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKAGT 175
Cdd:cd06261   82 LLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGT 161

                        170       180
                 ....*....|....*....|...
gi 578270526 176 MLTNVTYQPFKVFALVALGYFIL 198
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALI 184
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 50-166 1.94e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.52  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   50 VKRLIRGYIELFQGTPLLMQLFLaFFGVALLGIDVSPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFG 129
Cdd:pfam00528  16 LDRLLRPLIDLLQALPSFVLAIL-LVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRW 94

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 578270526  130 QTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIG 166
Cdd:pfam00528  95 QIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLG 131
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 8-217 3.16e-67

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 205.69  E-value: 3.16e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   8 WDIIRNLLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPW 87
Cdd:COG0765    9 LDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  88 TAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGF 167
Cdd:COG0765   89 VAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGV 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578270526 168 IELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKFNASH 217
Cdd:COG0765  169 PELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 7-215 8.95e-35

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 123.28  E-value: 8.95e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   7 DWDIIRN---LLLAG-RWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGI 82
Cdd:COG4160    2 DLDLLFEylpLLLSGlPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  83 --DV-------SPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAV 153
Cdd:COG4160   82 vrESwlwpllrDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578270526 154 QVIKGTALASIIGFIELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKFNA 215
Cdd:COG4160  162 LMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLR 223
PRK15100 PRK15100
cystine ABC transporter permease;
14-214 2.70e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 116.39  E-value: 2.70e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  14 LLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPWTAASLA 93
Cdd:PRK15100  15 LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMIG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  94 LTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKA 173
Cdd:PRK15100  95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQ 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578270526 174 GTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKFN 214
Cdd:PRK15100 175 AQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLN 215
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 14-210 9.33e-26

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 99.54  E-value: 9.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   14 LLLAGRW-TVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPWTAASL 92
Cdd:TIGR03004   6 LLLQGAWvTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   93 ALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTK 172
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 578270526  173 AGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLE 210
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLE 203
artM PRK11122
arginine ABC transporter permease ArtM;
50-212 1.05e-21

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 88.86  E-value: 1.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  50 VKRLIRGYIELFQGTPLLMQLFLAFFG----VALLGIDV------SPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWE 119
Cdd:PRK11122  44 LVWLVRGYITLFTGTPLLVQIFLIYYGpgqfPWLQEYPWlwhllsQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQ 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526 120 ASRCLGLTFGQTLfRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKAGTMLTNVTYQpFKVFALVALGYFILC 199
Cdd:PRK11122 124 SCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKSTSLAYTITLMDVMGYSQLLYGRTYD-VMVFGAAGIIYLVVN 201

                        170
                 ....*....|...
gi 578270526 200 YPLSRYSRYLETK 212
Cdd:PRK11122 202 GLLTLLMRLIERK 214
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 8-212 1.42e-21

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 88.57  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   8 WDIIRNLLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFG--VALLGIDVS 85
Cdd:PRK09494   9 WPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFAlpMAFNDLRID 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  86 PWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASII 165
Cdd:PRK09494  89 PFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVI 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 578270526 166 GFIELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETK 212
Cdd:PRK09494 169 GVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 7-213 2.65e-20

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 84.90  E-value: 2.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526    7 DWDIIRNLL----LAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGI 82
Cdd:TIGR03003   2 DWEFVRQILptliEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   83 DVSPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALA 162
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578270526  163 SIIGFIELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKF 213
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 81-198 1.11e-18

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 83.27  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  81 GIDVSP-WTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGT 159
Cdd:COG4597  258 GLTLSPeFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNS 337

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 578270526 160 ALASIIGFIEL--TKAGTMLtNVTYQPFKVFALVALGYFIL 198
Cdd:COG4597  338 SLAVAIGYPDLvsVFAGTTL-NQTGQAIEIIAITMAVYLTI 377
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 10-106 2.60e-17

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 74.11  E-value: 2.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   10 IIRNLLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLGIDVSPWTA 89
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*..
gi 578270526   90 ASLALTFYTSAFLLDIW 106
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIF 97
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
56-192 1.89e-13

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 66.74  E-value: 1.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  56 GYIELFQGTPLLMQLFLAFFGVAL--------LG---IDVSPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCL 124
Cdd:PRK15135  51 GYTTLIRGVPDLVLMLLIFYGLQIalnsvteaLGvgqIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAF 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578270526 125 GLTFGQTLFRVVAPQALRIAIaPTVGFAVQVI-KGTALASIIGFIELTKAGTMLTNVTYQPFkVFALVA 192
Cdd:PRK15135 131 GFTRGQVFRRIMFPAMMRYAL-PGIGNNWQVIlKATALVSLLGLEDVVKATQLAGKSTWEPF-YFAIVC 197
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
14-213 2.48e-13

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 66.62  E-value: 2.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  14 LLLAGRWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFG----------------- 76
Cdd:PRK11123   7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGssqllltlsdgftlnlg 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  77 -------VALLGIDVSPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIaPTV 149
Cdd:PRK11123  87 fvqipvqMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHAL-PGL 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578270526 150 GFAVQV-IKGTALASIIGFIELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRYLETKF 213
Cdd:PRK11123 166 GNQWLVlLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRA 230
PRK15069 PRK15069
histidine ABC transporter permease HisM;
51-202 2.49e-11

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 60.83  E-value: 2.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  51 KRLIRG----YIELFQGTPLLMQLFLAFFGV-ALLGIDVSPWTAA---------SLALTFYTSAFLLDIWFGSIRALPKG 116
Cdd:PRK15069  52 NKWIRFpvwlYTYVFRGTPLYVQLLVFYTGMySLEIVRGTDLLDAffrsglnctILAFTLNTCAYTTEIFAGAIRSVPHG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526 117 QWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKAGTMLTNVTYQPFKVFALVALGYF 196
Cdd:PRK15069 132 EIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYL 211


                 ....*.
gi 578270526 197 ILCYPL 202
Cdd:PRK15069 212 IISFVL 217
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 19-198 4.23e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 59.60  E-value: 4.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  19 RWTVLLSLVAFVGGAAVTLPLLLLRLTGGRTVKRLIRGYIELFQGTPLLMQLFLAFFGVALLG---IDVSPWTAASLALT 95
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  96 FYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKAGT 175
Cdd:cd06261   82 LLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGT 161

                        170       180
                 ....*....|....*....|...
gi 578270526 176 MLTNVTYQPFKVFALVALGYFIL 198
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALI 184
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 50-166 1.94e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.52  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526   50 VKRLIRGYIELFQGTPLLMQLFLaFFGVALLGIDVSPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFG 129
Cdd:pfam00528  16 LDRLLRPLIDLLQALPSFVLAIL-LVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRW 94

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 578270526  130 QTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIG 166
Cdd:pfam00528  95 QIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLG 131
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
57-212 2.38e-03

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 37.89  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  57 YIELFQGTPLLMQLFLAFFGVALLGIDV---SPWT-----AASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTF 128
Cdd:PRK15107  59 YVNVFRSIPLVMVLLWFYLIVPGFLQNVlglSPKTdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTH 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526 129 GQTLFRVVAPQALRIAIAPTVGFAVQVIKGTALASIIGFIELTKAGTMLTNVTYQPFKVFALVALGYFILCYPLSRYSRY 208
Cdd:PRK15107 139 WQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSY 218


                 ....
gi 578270526 209 LETK 212
Cdd:PRK15107 219 LKKR 222
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
56-146 3.12e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 38.22  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578270526  56 GYIELFQGTPLLMQLFLAFFGVALlgIDVSPWTAASLALTFYTSAFLLDIWFGSIRALPKGQWEASRCLGLTFGQTLFRV 135
Cdd:COG1178  110 AWIALFGPNGLLNTLLRALFGLEP--PDIYGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRV 187

                         90
                 ....*....|.
gi 578270526 136 VAPQALRIAIA 146
Cdd:COG1178  188 TLPLLRPAIAA 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH