|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
2-553 |
1.08e-153 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 450.38 E-value: 1.08e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 2 SESKEMVRGTFLITISILITKVLGVLFIIPFNYLIGGqENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNAIGAYK 81
Cdd:COG5841 1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGD-EGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 82 VSQKFYKSSFIVMSITGVLGFLVLYFLAPYISELTLARnihdkngwsvDDITWIIRIISMVVIFIPVLATWRGIFQGYKS 161
Cdd:COG5841 80 GARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGD----------PRAYYSLRALAPALLIVPVMSVLRGYFQGLQN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 162 MGPTAVSEVTEQIARVIFILIGSYLVLNVfdgSILLANGIATFAAAVGAIIGIFTLWYYWRKRKHNIDRMVESDYTDIDV 241
Cdd:COG5841 150 MTPTAVSQVIEQIVRVIFILLLAYLLLPY---GLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSKE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 242 SYGKMYKEIIAYSIPFVIVSLNYPLFNLVDQFTHNGALSLVGIPSQLQDIFFNMLNMSTNKIVMIPTSLSAGFAVSLIPY 321
Cdd:COG5841 227 SSKDILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 322 ITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDpivlghdpnhDGSRLLFYYAPVAILISLLS 401
Cdd:COG5841 307 ISEAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNP----------EGGGILAILAPSAIFLSLQQ 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 402 VTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCNFYILKKYAKFKFSYsWIHFAKIF 481
Cdd:COG5841 377 VTTGILQGLGKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLDL-RRRLLKPL 455
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 579796988 482 LYSFIMMLGVELVFFLANLFLEPTKLGYLIIIILGVTVGILIYGTITIKTRLAD-EFLGEIPEKLRRRVRFLR 553
Cdd:COG5841 456 LASLIMGIVVLLLYRLLSLFLPESRLGALLATLIAVLVGAIVYLLLLLKLGLITkEELRRLPKGGKKLARLLR 528
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
12-468 |
2.27e-124 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 371.80 E-value: 2.27e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 12 FLITISILITKVLGVLFIIPFNYLIGGqENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNAIGAYKVSQKFYKSSF 91
Cdd:cd13124 1 LILTIAGLISKILGAIYRIPLQNIIGD-EGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 92 IVMSITGVLGFLVLYFLAPYISELTLarnihdkngwSVDDITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPTAVSEVT 171
Cdd:cd13124 80 ILLLILGLVFFLLLFFGAPFLAQLLL----------GDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 172 EQIARVIFILIGSYLVLNVfDGSILLANGIATFAAAVGAIIGIFTLWYYWRKRKHNIDRMVESDYTDIdVSYGKMYKEII 251
Cdd:cd13124 150 EQIVRVIVILVLAYLLLPV-GGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSK-ISTKEILKELL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 252 AYSIPFVIVSLNYPLFNLVDQFTHNGALSLVGIPSQLQDIFFNMLNMSTNKIVMIPTSLSAGFAVSLIPYITKTFAEGRL 331
Cdd:cd13124 228 SYAIPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 332 HEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDpivlghdpnhDGSRLLFYYAPVAILISLLSVTASMLQGID 411
Cdd:cd13124 308 KELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS----------EGGLILQILAPSILFLSLQQVTAAILQGLG 377
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 579796988 412 KQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCNFYILKKYAKF 468
Cdd:cd13124 378 KVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
9-524 |
1.21e-31 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 127.79 E-value: 1.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 9 RGTFLITISILITKVLGVLFIIPFNYLIGgQENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNAIGAYKVSQKFYK 88
Cdd:TIGR02900 3 KGTFILTIANLITRILGFIFRIVLSRILG-AEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKILK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 89 SSFIVMSITGVLGFLVLYFLAPYISELTLarniHDKNgwsvddITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPTAVS 168
Cdd:TIGR02900 82 VSLIFTLIWSLIVTAIVFLLSPFIASTLL----KDER------SLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 169 EVTEQIARVIFILIGSYLVLNVfdgSILLANGIATFAAAVGAIIGIFTLWYYWRKRKHNIDRMVESDYtdidVSYGKMY- 247
Cdd:TIGR02900 152 QVIEQIVRISVVALLISAFLPY---GLEYAVAGAYLSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDY----KSEGKALl 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 248 KEIIAYSIPFVIVSLNYPLFNLVDQ-----------FTHNGALSLVGipsqlqdIFFNMLNMSTNKIVMIPTSLSagfaV 316
Cdd:TIGR02900 225 FDLFSVSLPLTLSRFIGSLLYFLETllvpqrlviagVTYREATSLYG-------KLSGMAMPLLTFPAVITSSLS----T 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 317 SLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDpivlghdpnhDGSRLLFYYAPVAIL 396
Cdd:TIGR02900 294 ALVPDISEAMAKKNYSSIEKRINQAIKISLLLGLITTVILLVIPDELGALFYGRP----------DAGNFIRVLAPSFPF 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 397 ISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPL--IMLFHTPGAILSTSIALLFAIGCNFYILKKYAKFKFSYSw 474
Cdd:TIGR02900 364 LYFSAPLQSILQGLGKQKVALRNSLIGAIVKIILLFVLtsIPSINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLS- 442
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 579796988 475 ihfaKIFLYSFIMMLGvelVFFLANLFLEPTKLGYLIIIILGVTVGILIY 524
Cdd:TIGR02900 443 ----DFLIFALLGILV---YLGLSLLKYIIFNPNILINLLLIIILGFSLY 485
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
7-463 |
5.07e-29 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 118.80 E-value: 5.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 7 MVRGTFLITISILITKVLGVLFIIPF-NYLigGQENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNaigaYKVSQK 85
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLaRYL--GPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYR----KEKIRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 86 FYKSSFIVMSITGVLGFLVLYFLAPYISeltlarnihdkngWSVDDITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPT 165
Cdd:cd13128 75 IISTSLVLKLILGILALLLLFLFAFLIA-------------FYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 166 AVSEVTEQIARVIFILIGSYLVLNVFdgsillangIATFAAAVGAIIGIFTLWYYWRKRKHNIDRMVESDytdidvsygK 245
Cdd:cd13128 142 VIARIIESVLSLILALILVLLGGGLI---------GFALAYLIASVLSAILLLYIYRKKILLPKFFSFDL---------K 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 246 MYKEIIAYSIPFVIVSLNYPLFNLVDQF--THNGALSLVGIPSqlqdiffnmlnmSTNKIVMIPTSLSAGFAVSLIPYIT 323
Cdd:cd13128 204 LAKELLRFSIPLALSGIFSLIYTRIDTImlGYFLGDAAVGIYN------------AAYRIAELLLFIPSAISTALFPRIS 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 324 KTFAEGRLhEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDpivlghdpNHDGSRLLFYYAPVAILISLLSVT 403
Cdd:cd13128 272 ELYKNDKD-ELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--------YLPAALVLQILAWGFLFIFLNGIF 342
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 404 ASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCNFYILK 463
Cdd:cd13128 343 GSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
8-533 |
3.43e-20 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 93.68 E-value: 3.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 8 VRGTFLITISILITKVLGVLFIIPFNYLIGGQENMAPFTYAYAPYNIAI------AVATAGVPLAaSKYVAKYNAIGAYK 81
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVADAFFVAFRIPNLLRrlfaegALSAAFVPVL-AEALEKEGEEEARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 82 VSQKFYKSSFIVMSITGVLGFLvlyfLAPYISELTLArnihdknGWSVDDI---TWIIRIISMVVIFIPVLATWRGIFQG 158
Cdd:COG0728 80 FASRVLTLLLLVLLVLTLLGIL----FAPLLVKLLAP-------GFDPEKFalaVALTRIMFPYILFIGLSALLGGVLNA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 159 YKSMGPTAvsevteqIARVIF--ILIGSYLVLNVFDGSILLANGIATFaaaVGAIIGIFTLWYYWRKRKHNIdrMVESDY 236
Cdd:COG0728 149 RGRFAAPA-------LAPVLLnlVIIAGLLLLAPLFGPGIYALAWGVL---LGGVLQLLIQLPALRRLGLRL--RPRFDL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 237 TDIDVsygkmyKEIIAYSIPFVIVSLNYPLFNLVDQFthngalslvgIPSQLQDIFFNMLNMStNKIVMIPTSL-SAGFA 315
Cdd:COG0728 217 RDPGV------RRVLKLMLPALLGVSVSQINLLVDTI----------LASFLPEGSVSALYYA-DRLYQLPLGLfGVAIG 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 316 VSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYdpivlGHDPNHDG---SRLLFYYAP 392
Cdd:COG0728 280 TALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFER-----GAFTAEDTaltALALAAYAL 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 393 VAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCNFYILKKYAKFKFSY 472
Cdd:COG0728 355 GLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLR 434
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 579796988 473 SWI-HFAKIFLYSFIMMLGVELVFFLANLFLEPTKLGYLIIIILGVTVGILIYGTITIKTRL 533
Cdd:COG0728 435 GILrTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFALLLLLGV 496
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
386-533 |
7.04e-19 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 83.01 E-value: 7.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 386 LLFYYAPVAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCNFYILKKY 465
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 579796988 466 AKFKFSYSWIhfAKIFLYSFIMMLGVELVFFLANLFleptkLGYLIIIILGVTVGILIYGTITIKTRL 533
Cdd:pfam14667 81 LGLRLLLRRL--LKPLLAALVMGIVVYLLLLLLGLL-----LGLALALLLAVLVGALVYLLLLLLLKL 141
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
5-454 |
2.97e-16 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 80.38 E-value: 2.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 5 KEMVRGTFLITISILITKVLGVLFIIPFNYLIGgQENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNAIGAykvsQ 84
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLG-PEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEEL----R 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 85 KFYKSSFIVMSITGVLGFLVLYFLAPYISELtlarnihdkngWSVDDITWIIRIISMVVIFIPVLATWRGIFQGYKSMGP 164
Cdd:COG2244 77 RLLSTALLLRLLLSLLLALLLLLLAPFIAAL-----------LGEPELALLLLLLALALLLSALSAVLLALLRGLERFKL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 165 TAVSEVTEQIARVIFILIGSYLVlnvfdgsillangiatfaaavgaiigiFTLWYYwrkrkhnidrmvesdytdidvsyg 244
Cdd:COG2244 146 LALINILSSLLSLLLALLLALLG---------------------------LGLWGL------------------------ 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 245 kmykeIIAYSIPFVIVSLNYPLFNLVDQFthngalsLVGIPSQLQDI-FFNMlnmsTNKIVMIPTSLSAGFAVSLIPYIT 323
Cdd:COG2244 175 -----VLKYSLPLLLSGLLGLLLTNLDRL-------LLGALLGPAAVgIYSA----AYRLASLLLLLITALSQVLFPRLS 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 324 KTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGydpivlghDPNHDGSRLLFYYAPVAILISLLSVT 403
Cdd:COG2244 239 RLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFG--------PEYAEAAPVLPILALGALFLALSGVL 310
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 579796988 404 ASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFA 454
Cdd:COG2244 311 SNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVL 361
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
8-326 |
6.26e-16 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 78.11 E-value: 6.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 8 VRGTFLITISILITKVLGVLFIIPFNYLIGgQENMAPFTYAYAPYNIAIAVATAGVPLAASKYVAKYNAIGAYKvsqkfy 87
Cdd:pfam01943 2 LKNVIVLLLSQLITYLLAFVTLPYLARILG-PEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELV------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 88 kSSFIVMSITGVLGFLVLYFLAPYISELTLARnihdkngwsvDDITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPTAV 167
Cdd:pfam01943 75 -SLYWLNALLVKLVLVLLFLLLPLIAAFLGLP----------ELAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 168 SEVTEQIARVIFILIGSYLVlnvfdGSILLANGIATFAAAVGAIIGIFTLWYYWRKRKHNIDRmvesdytdidvsygKMY 247
Cdd:pfam01943 144 SQIVESLSRVILVFIAVFLP-----GDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFPSL--------------KLV 204
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 579796988 248 KEIIAYSIPFVIVSLNYPLFNLVDQFThngaLSLVGIPSQLqdiffNMLNMSTNKIVMIPTSLSAGFAVSLIPYITKTF 326
Cdd:pfam01943 205 RKLLSFGAPLFISSLAISLYTYIDSIL----LGLLLGAGAV-----GIYNAAYQLLVAIQGLLNPIVTAVLFPVFSKLQ 274
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
244-502 |
1.24e-11 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 66.71 E-value: 1.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 244 GKMYKEIIAYSIPFVIVSLNYPLFNLVDQF--THNGALSLVGIpsqlqdiffnmlnMSTNKIVMIPTSLSAGFAVSLIPY 321
Cdd:COG0534 4 GPILKLLLRLALPIILGNLLQSLYGLVDTIfvGRLGTAALAAV-------------GLAFPIFFLLIALGIGLGVGGTAL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 322 ITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFyGYDPIVLGHdpnhdGSRLLFYYAPVAILISLLS 401
Cdd:COG0534 71 VAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLL-GADPEVLAL-----ARDYLRIILLGLPFLLLFN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 402 VTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFH--TPGAILSTSIALLFAIGCNFYILKK------YAKFKFSYS 473
Cdd:COG0534 145 VLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGGGlgVAGAALATVISQAVSALLLLYYLFRkrsllrLRLRDLRPD 224
|
250 260 270
....*....|....*....|....*....|..
gi 579796988 474 WIHFAKIF---LYSFIMMLGVELVFFLANLFL 502
Cdd:COG0534 225 RKILKRILrigLPAGLQQLAESLGFLVLNALV 256
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
301-464 |
3.05e-09 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 59.00 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 301 NKIVMIPTSLsagFAVSLI----PYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYdpivlG 376
Cdd:cd13123 257 DRLYQLPLGI---FGVAIAtallPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFER-----G 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 377 HDPNHDG---SRLLFYYAPVAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLF 453
Cdd:cd13123 329 AFTAEDTlmtASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWV 408
|
170
....*....|.
gi 579796988 454 AIGCNFYILKK 464
Cdd:cd13123 409 NALLLLVLLRR 419
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
246-502 |
1.84e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 56.70 E-value: 1.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 246 MYKEIIAYSIPFVIVSLNYPLFNLVD-----QFTHNGALSLVGIPSQlqdiffnmlnmstnkIVMIPTSLSAGFAVSLIP 320
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDllivgQFLGVAALAAVSNGSP---------------IIFLLTAIGMGLSMGGTI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 321 YITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDPIVlghdpnHDGSRLLFYYAPVAILISLL 400
Cdd:cd13138 66 LISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEIL------ELAVSYLRICFLGIPFIFGY 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 401 SVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFH--TPGAILSTSIA-LLFAIGCNFYILKKYAKFKFSYSWIHF 477
Cdd:cd13138 140 NAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHmgVAGAALATVIAqAISVLLALYYLRKKKLPFKLSLKDFRF 219
|
250 260 270
....*....|....*....|....*....|
gi 579796988 478 AKIFLYSfIMMLGV-----ELVFFLANLFL 502
Cdd:cd13138 220 DKEILKE-ILKIGLpsalqQSLVSISFLII 248
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
300-516 |
3.47e-08 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 55.76 E-value: 3.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 300 TNKIVMIPTSL-SAGFAVSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDpiVLGHD 378
Cdd:pfam03023 238 ADRIYQLPLGIfGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERG--NFSPE 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 379 PNHDGSRLLFYYAPVAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHTPGAILSTSIALLFAIGCN 458
Cdd:pfam03023 316 DVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFL 395
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 579796988 459 FYILKKYAKFKFSYSWIHFAKIFLYSFIMMLGVelVFFLANLFLEPTKLGYLIIIILG 516
Cdd:pfam03023 396 YYILRKRLGGFDLRGIKTFLASLVVPTALMAGV--ILLLSSLTQGPWVVGSLLLILVG 451
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
16-455 |
1.31e-07 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 53.87 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 16 ISILITKVLGVLFIIPFNYLIG--GQENMAPFTYAYAPYNIAIAvATAGVPLAASKYVAKYNAIGAYKVSQKFYKSSFIV 93
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGrlLGDALAAVGLAFPLIALLIA-LGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 94 MSITGVLGFLVLYFLAPYISELTLArnihdkNGWSVDDITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPTAVSEVTEQ 173
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGA------EEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 174 IARVIFILIGSYLVLNVFDGSIllangIATFAAAVGAIIGIFTLWYYWRKRKHNIDRMVESDYTDIdvsygKMYKEIIAY 253
Cdd:cd12082 155 LLNILLDPLLIFGLGPPELGIA-----GAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDL-----ELLRRLLRI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 254 SIPFVIVSLNYPLF-----NLVDQFTHNGALSLVGIpsqlqdiffnmlnmsTNKIVMIPTSLSAGFAVSLIPYITKTFAE 328
Cdd:cd12082 225 GLPSAIQNSLLSLGlliivAIVAAFGGAAALAAYTV---------------AFRIASLAFMPALGLAQAALPVVGQNLGA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 329 GRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDPIVlghdpnHDGSRLLFYYAPVAILISLLSVTASMLQ 408
Cdd:cd12082 290 GNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFL------ELAVSYLRILAIYYLFVGIGYVLQAGFQ 363
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 579796988 409 GIDKQKL-TVYVILASVVIKLALNYPLIML-FHTPGAILSTSIALLFAI 455
Cdd:cd12082 364 AAGRTLKsLIVSLLSYWVVRLPLAYVLAYLgLGLYGIWLALVISLILAA 412
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
82-470 |
1.26e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 50.95 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 82 VSQKFYKSSFIVMSITGVLGFLVLYFLAPYISELtlarnihdkngWSVDDITWIIRIISMVVIFIPVLATWRGIFQGYKS 161
Cdd:cd13127 66 LTEEDLSTVFWLNLLLGLLLYLLLFLLAPLIAAF-----------YNEPELIPLLRVLSLSFLLSGLGSVPRALLQRELR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 162 MGPTAVSEVteqIARVIFILIGSYLVLNVFDGSILLANGIATfAAAVGAIIGIFTLWYYWRKRKHnidrmvesdytdidv 241
Cdd:cd13127 135 FKKLAIIEL---ISTLVSGVVAIVLALLGFGVWALVAQQLVG-ALVSTVLLWILSRWRPRLSFSL--------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 242 sygKMYKEIIAYSIPFVivslnypLFNLVDQFTHNGALSLVGI---PSQLqdiffNMLNMSTNKIVMIPTSLSAGFAVSL 318
Cdd:cd13127 196 ---ASLKELLSFGSKLL-------GSNLLNYFSRNLDNLIIGKflgAAAL-----GYYSRAYRLALLPVQNITGPITRVL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 319 IPYITKtfAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYG--YDPIVLghdpnhdgsrLLFYYAPVAIL 396
Cdd:cd13127 261 FPALSR--LQDDPERLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGekWLPAVP----------ILQILALAGLF 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 579796988 397 ISLLSVTASMLQGIDKQKLTVYVILASVVIKLALnYPLIMLFHTPGAILSTSIALLFAIGCNFYILKKYAKFKF 470
Cdd:cd13127 329 QPLSSLNGSLLLALGRTDLLLKLGLIKAVLTVLA-LLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGRLIGISL 401
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
303-497 |
1.71e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 50.59 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 303 IVMIPTSLSAGFAVSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFYGYDPIVlghdpnHD 382
Cdd:cd13137 45 VLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVI------AL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 383 GSRLLFYYAPVAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIM-LFHTP-----GAILSTSIALLFAIG 456
Cdd:cd13137 119 ALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLIFgLWGFPglgvaGAALATVISRVVGAL 198
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 579796988 457 CNFYIL---KKYAKFKFSYSWIHFA------KIFLYSFIMMLGVELVFFL 497
Cdd:cd13137 199 LLLFLLlrgRLPIKISFKGFRLDRKiikkllRIGLPAGLEQLLRSLGFLV 248
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
300-432 |
3.66e-06 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 47.17 E-value: 3.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 300 TNKIVMIPTSLSAGFAVSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTvFYGYDPIVLghdp 379
Cdd:pfam01554 34 ANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEPILS-LFGQDEEVL---- 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 579796988 380 nHDGSRLLFYYAPVAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNY 432
Cdd:pfam01554 109 -ALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
245-502 |
1.62e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 44.04 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 245 KMYKEIIAYSIPFVIVSLNYPLFNLVDQF---THNGALSLVGIpsqlqdiffnmlnMSTNKIVMIPTSLSAGFAVSLIPY 321
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIfvgHGVGALALAAV-------------NLVFPIIMLLMALGLMIGVGGASL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 322 ITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTVFyGYDPIVLGHdpnhdGSRLLFYYAPVAILISLLS 401
Cdd:cd13143 68 ISRRLGAGDREKANRIFSTALLLSLILGLLLTILGLLFLDPLLRLL-GASGELLPY-----AVDYLRIILLGAPFTILSS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 402 VTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFH--TPGAILSTSIALLFAIGCNF-YILKKYAKFKFSYSWIHFA 478
Cdd:cd13143 142 VLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVLGlgIAGAALATVIAQLISLLLLLlYFFRGKSLLKLSLLRFKLS 221
|
250 260 270
....*....|....*....|....*....|..
gi 579796988 479 KIFLY--------SFIMMLGVELVFFLANLFL 502
Cdd:cd13143 222 LKIIKeilalgfpSFLMQLSSSVVTIVLNLTL 253
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
246-474 |
4.32e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 42.94 E-value: 4.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 246 MYKEIIAYSIPFVIVSLNYPLFNLVDQFT--HNGALSLVGipSQLQDIFFNMLNMStnkiVMIptslsaGFAVSLIPYIT 323
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFvgHLGKLELAA--ASLASSFANVTGFS----ILL------GLASALDTLCG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 324 KTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMaLAQPLFtvfygydpIVLGHDPN--HDGSRLLFYYAPVAILISLLS 401
Cdd:cd13132 69 QAFGAKNYKLVGVYLQRALVILLLCCVPISLLWL-NTEPIL--------LLLGQDPEiaRLAGEYLRWLIPGLFAYALFE 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 579796988 402 VTASMLQGIDKQKLTVYVILASVVIKLALNYPLIMLFHT--PGAILSTSIALLFAIGCNFYILKKYAKFKFSYSW 474
Cdd:cd13132 140 PLKRYLQAQGIVLPLVYISLVALLLNILLNYLLVFVLGLgfIGAALATSISYWLIVVLLLLYIFFSKGHKATWGG 214
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
247-487 |
5.65e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 42.49 E-value: 5.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 247 YKEIIAYSIPFVIVSLNYPLFNLVDQFTHNG----ALSLVGIPSQLQDIFFNMLNMstnkivmiptsLSAGFAVslipYI 322
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRysdnAVAAVGVANQILFLLILIFSF-----------ISTGTSI----LI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 323 TKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFTvFYGYDPIVLGHdpnhdGSRLLFYYAPVAILISLLSV 402
Cdd:cd13134 67 AQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLR-LMGLPPELLAL-----GSTYLRIVGGSLFLQALSLT 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 403 TASMLQGIDKQKLTVYVILASVVIKLALNYPLIM-LFHTP-----GAILSTSIALLFAIGCNFYILKKYAKFKFSY-SWI 475
Cdd:cd13134 141 LSAILRSHGRTKIPMYVSLIMNILNIVGNYLLIFgWFGLPklgvaGVAISTVISRAVGLVLLFILLFRKLKIRFRLkDLR 220
|
250
....*....|..
gi 579796988 476 HFAKIFLYSFIM 487
Cdd:cd13134 221 PFPKKLLKKILK 232
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
313-480 |
1.18e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 41.33 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 313 GFAVSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPAsIGIMALAQPLFTVFyGYDPIVLghdpnHDGSRLLFYYAP 392
Cdd:cd13131 57 GLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPL-MLLLWLAPPILPLM-GQEPEVA-----AIARGYLLALAW 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 393 VAILISLLSVTASMLQGIDKQKLTVYVILASVVIKLALNYPLIM-LFHTP-----GAILSTSIALLFAIGCNFYILKKYA 466
Cdd:cd13131 130 GIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIFgKFGLPalggaGAGLATAIVYWLMFLALAFYIRRHK 209
|
170
....*....|....
gi 579796988 467 KFKFSYSWIHFAKI 480
Cdd:cd13131 210 RFRRYRLFARFWRP 223
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
256-502 |
1.23e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 41.08 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 256 PFVIVSLNYPLFNLVDQFT--HNGALSLVGIpsqlqdIFFNMLNMSTNKIVMiptslsaGFAVSLIPYITKTFAEGRLHE 333
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFvgHLGPVDLAAV------SLGSSVFMFLFSILM-------GLGTATTALVAQAVGAGNYQR 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 334 MHHQIRTSIGVLMFITVPASIgIMALAQPLFTVFYGYDPIVLghDPNHDGSRLLFYYAPvAILISLLSvtASMLQGIDKQ 413
Cdd:TIGR00797 68 LGRQAQQSLLLALLLGLPVLL-VGYFFIDPLLSLMGADGEVA--ELAQDYLRILILGIP-AYLLNFVL--RGFLRGQGDT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 414 KLTVYVILASVVIKLALNYPLIMLFHTP----GAILSTSIA--LLFAIG-CNFYILKKYAKFKFSYSWIHFA------KI 480
Cdd:TIGR00797 142 KTPMYITLIGNVINIILNYILIFGKFGFlgivGAALATVISywLMFLLLlYYIKKAKKIGLKWEGLLKPDWEvlkrllKL 221
|
250 260
....*....|....*....|..
gi 579796988 481 FLYSFIMMLGVELVFFLANLFL 502
Cdd:TIGR00797 222 GLPIAFRVILESLSFALLALLV 243
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
52-454 |
1.62e-03 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 40.90 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 52 YNIAIAVATAGVPLaaskyVAKYNAIGAYKVSQKFYKSSFIVMSITGVLGFLVLYFLAPYISELTLArnihdkNGWSVDD 131
Cdd:COG0534 57 IALGIGLGVGGTAL-----VAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGA------DPEVLAL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 132 ITWIIRIISMVVIFIPVLATWRGIFQGYKSMGPTAVSevteQIARVIFILIGSYLVLNVFDGSILLAnGIATFAA-AVGA 210
Cdd:COG0534 126 ARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMII----MLIGNVLNIVLDPLLIFGGGLGVAGA-ALATVISqAVSA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 211 IIGIFTLWYYWRKRKHNIDRMVESdytdidvsyGKMYKEIIAYSIP-----FVIVSLNYPLFNLVDQFTHNgALSLVGIp 285
Cdd:COG0534 201 LLLLYYLFRKRSLLRLRLRDLRPD---------RKILKRILRIGLPaglqqLAESLGFLVLNALVARLGTA-AVAAYGI- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 286 sqlqdiffnmlnmsTNKIVMIPTSLSAGFAVSLIPYITKTFAEGRLHEMHHQIRTSIGVLMFITVPASIGIMALAQPLFT 365
Cdd:COG0534 270 --------------ALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579796988 366 VFyGYDPIVLGHdpnhdGSRLLFYYAPVAILISLLSVTASMLQGIDKQKLTVYV-ILASVVIKLALNYPLIMLFHTP-GA 443
Cdd:COG0534 336 LF-TDDPEVIAL-----AATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIsLLRLWLVRLPLAYLLAFLGLGLtGV 409
|
410
....*....|.
gi 579796988 444 ILSTSIALLFA 454
Cdd:COG0534 410 WLALPIGEVLR 420
|
|
| |
