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Conserved domains on  [gi|582775136|gb|EWA62546|]
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hypothetical protein U426_02771, partial [Staphylococcus aureus T33147]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 1-110 5.71e-21

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member PRK08116:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 268  Bit Score: 84.30  E-value: 5.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   1 VAFMHIPMLMDRIKATYNKNAVETTDELVRLLSDIDLLVLDDMGVE-NTEHTLNKLFSIVDNRV--GKNNIFTTNFSDKE 77
Cdd:PRK08116 145 VIFVNFPQLLNRIKSTYKSSGKEDENEIIRSLVNADLLILDDLGAErDTEWAREKVYNIIDSRYrkGLPTIVTTNLSLEE 224

                         90       100       110
                 ....*....|....*....|....*....|...
gi 582775136  78 LnQNMNWQRINSRMKHNARKVRVIGDDFRERDA 110
Cdd:PRK08116 225 L-KNQYGKRIYDRILEMCTPVENEGKSYRKEIA 256
 
Name Accession Description Interval E-value
PRK08116 PRK08116
hypothetical protein; Validated
 1-110 5.71e-21

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 84.30  E-value: 5.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   1 VAFMHIPMLMDRIKATYNKNAVETTDELVRLLSDIDLLVLDDMGVE-NTEHTLNKLFSIVDNRV--GKNNIFTTNFSDKE 77
Cdd:PRK08116 145 VIFVNFPQLLNRIKSTYKSSGKEDENEIIRSLVNADLLILDDLGAErDTEWAREKVYNIIDSRYrkGLPTIVTTNLSLEE 224

                         90       100       110
                 ....*....|....*....|....*....|...
gi 582775136  78 LnQNMNWQRINSRMKHNARKVRVIGDDFRERDA 110
Cdd:PRK08116 225 L-KNQYGKRIYDRILEMCTPVENEGKSYRKEIA 256
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-110 3.45e-13

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 62.88  E-value: 3.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   1 VAFMHIPMLMDRIKATYNKNAVEttdELVRLLSDIDLLVLDDMGVEN-TEHTLNKLFSIVDNRVGKNN-IFTTNFSDKEL 78
Cdd:COG1484  130 VRFTTAPDLVNELKEARADGRLE---RLLKRLAKVDLLILDELGYLPlDAEGAELLFELISDRYERRStIITSNLPFSEW 206

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 582775136  79 NQNMN----WQRINSRMKHNARKVRVIGDDFRERDA 110
Cdd:COG1484  207 GEVFGdptlATAILDRLVHHAHIIELKGESYRLKEA 242
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 26-109 1.17e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 36.68  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136  26 DELVRLLSDIDLLVLDDMGVE--NTEHTlNKLFSIVDNRVGKNN-IFTTN--FSDkelnqnmnWQRI--NSRMK------ 92
Cdd:NF038214 143 GRLLRRLARYDLLIIDELGYLpfSREGA-NLLFELIADRYERGStIITSNlpFSE--------WGEVfgDPTLAaaildr 213

                         90
                 ....*....|....*....
gi 582775136  93 --HNARKVRVIGDDFRERD 109
Cdd:NF038214 214 lvHHAHILELKGESYRLKE 232
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 24-108 6.73e-03

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 34.34  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   24 TTDELVRLLS----------------DIDLLVLDDMGVENTEHT-LNKLFSIVDNRVGKNN-IFTTNFSDKELNQNMNWQ 85
Cdd:pfam01695 127 SAADLVNQLKrahgdgkltrklqqllKPDVLILDEWGYLPLDQAeANLLFQVISKRYEHRSiILTSNLPFGEWGQVFGDA 206

                          90       100
                  ....*....|....*....|....*..
gi 582775136   86 RINS----RMKHNARKVRVIGDDFRER 108
Cdd:pfam01695 207 VLATaildRLLHHCHIVPIKGESYRLK 233
 
Name Accession Description Interval E-value
PRK08116 PRK08116
hypothetical protein; Validated
 1-110 5.71e-21

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 84.30  E-value: 5.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   1 VAFMHIPMLMDRIKATYNKNAVETTDELVRLLSDIDLLVLDDMGVE-NTEHTLNKLFSIVDNRV--GKNNIFTTNFSDKE 77
Cdd:PRK08116 145 VIFVNFPQLLNRIKSTYKSSGKEDENEIIRSLVNADLLILDDLGAErDTEWAREKVYNIIDSRYrkGLPTIVTTNLSLEE 224

                         90       100       110
                 ....*....|....*....|....*....|...
gi 582775136  78 LnQNMNWQRINSRMKHNARKVRVIGDDFRERDA 110
Cdd:PRK08116 225 L-KNQYGKRIYDRILEMCTPVENEGKSYRKEIA 256
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-110 3.45e-13

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 62.88  E-value: 3.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   1 VAFMHIPMLMDRIKATYNKNAVEttdELVRLLSDIDLLVLDDMGVEN-TEHTLNKLFSIVDNRVGKNN-IFTTNFSDKEL 78
Cdd:COG1484  130 VRFTTAPDLVNELKEARADGRLE---RLLKRLAKVDLLILDELGYLPlDAEGAELLFELISDRYERRStIITSNLPFSEW 206

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 582775136  79 NQNMN----WQRINSRMKHNARKVRVIGDDFRERDA 110
Cdd:COG1484  207 GEVFGdptlATAILDRLVHHAHIIELKGESYRLKEA 242
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 31-108 3.81e-07

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 46.43  E-value: 3.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136  31 LLSDIDLLVLDDMGVE-NTEHTLNKLFSIVDNRV--GKNNIFTTNFSDKELNQNMNwQRINSRMKHNARKVRVIGDDFRE 107
Cdd:PRK06835 243 LLINCDLLIIDDLGTEkITEFSKSELFNLINKRLlrQKKMIISTNLSLEELLKTYS-ERISSRLLGNFTLLKFYGEDIRI 321


                 .
gi 582775136 108 R 108
Cdd:PRK06835 322 K 322
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 9-92 6.46e-04

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 37.44  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   9 LMDRIKATYNKNavETTDE-LVRLLSDIDLLVLDDMGVE-NTEHTLNKLFSIVDNRVG--KNNIFTTNFSDKELNqNMNW 84
Cdd:PRK07952 138 IMSAMKDTFSNS--ETSEEqLLNDLSNVDLLVIDEIGVQtESRYEKVIINQIVDRRSSskRPTGMLTNSNMEEMT-KLLG 214


                 ....*...
gi 582775136  85 QRINSRMK 92
Cdd:PRK07952 215 ERVMDRMR 222
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 26-109 1.17e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 36.68  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136  26 DELVRLLSDIDLLVLDDMGVE--NTEHTlNKLFSIVDNRVGKNN-IFTTN--FSDkelnqnmnWQRI--NSRMK------ 92
Cdd:NF038214 143 GRLLRRLARYDLLIIDELGYLpfSREGA-NLLFELIADRYERGStIITSNlpFSE--------WGEVfgDPTLAaaildr 213

                         90
                 ....*....|....*....
gi 582775136  93 --HNARKVRVIGDDFRERD 109
Cdd:NF038214 214 lvHHAHILELKGESYRLKE 232
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 24-108 6.73e-03

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 34.34  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582775136   24 TTDELVRLLS----------------DIDLLVLDDMGVENTEHT-LNKLFSIVDNRVGKNN-IFTTNFSDKELNQNMNWQ 85
Cdd:pfam01695 127 SAADLVNQLKrahgdgkltrklqqllKPDVLILDEWGYLPLDQAeANLLFQVISKRYEHRSiILTSNLPFGEWGQVFGDA 206

                          90       100
                  ....*....|....*....|....*..
gi 582775136   86 RINS----RMKHNARKVRVIGDDFRER 108
Cdd:pfam01695 207 VLATaildRLLHHCHIVPIKGESYRLK 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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