|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-364 |
1.39e-50 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 174.73 E-value: 1.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 10 FRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLL 89
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 90 IVIALVMIGFETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLI 169
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 170 IAMTIMMFLISIFMLFRLHVDKPtHSEEESTNSLLQEYLLGWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVL 249
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPP-AAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 250 KLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMN 329
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350
....*....|....*....|....*....|....*
gi 587124954 330 TAIMNTVSDKYVGRSFTIWTSISLLLQSLIAPFLG 364
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
10-364 |
6.64e-37 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 137.84 E-value: 6.64e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 10 FRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLL 89
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 90 IVIALVMIGFETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLI 169
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 170 IAMTIMMFLISIFMLFRLHVDKPTHSEEES-TNSLLQEYLLGWKFLKDNMMIFIFGVISIIPM-VFTMIFNISLPGYVYN 247
Cdd:TIGR00900 161 IWVDAVGFAISALLIVSVRIPELAASEIQAlSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNlVFAPAIVALFPYVQSK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 248 VLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGS-FILGYSISSIRI 326
Cdd:TIGR00900 241 YLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPNFPLFLVLwFAIGVGYGPINV 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 587124954 327 YMNTAIMNTVSDKYVGRSFTIWTSISLLLQSLIAPFLG 364
Cdd:TIGR00900 321 PQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAG 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-358 |
3.27e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.66 E-value: 3.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 6 KIKNFRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVI 85
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 86 LYLLIVIALVMigfetYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKING 165
Cdd:COG2814 88 GSLLCALAPSL-----WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 166 FTLIIAMTIMMFLISIFMLFRLhVDKPTHSEEESTNSLLQEYLLGWKFLkdnmmifIFGVISIIPMVFTMIFNISLPGYV 245
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRL-LPESRPAARARLRGSLRELLRRPRLL-------LLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 246 YNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIR 325
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|...
gi 587124954 326 IYMNTAIMNTVSDKYVGRSFTIWTSISLLLQSL 358
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-358 |
3.26e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.08 E-value: 3.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 13 FFLAEIISAFGVGISTVGANWYLIDKTN-DSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIV 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 92 IAlvmigFETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIA 171
Cdd:pfam07690 81 FA-----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 172 MTIMMFLISIFMLFrLHVDKPTHSEEESTNSLLQEYLLGWKFLKDNMMIFIFGVISIIPMVFTMIFnISLPGYVyNVLKL 251
Cdd:pfam07690 156 ILAILSLLAAVLLL-LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL-TYLPLYQ-EVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 252 SSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWI---NSAFYLFIGSFILGYSISSIRIYM 328
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|
gi 587124954 329 NTAIMNTVSDKYVGRSFTIWTSISLLLQSL 358
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-351 |
1.07e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.00 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 44 LLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITyllqviLYLLIVIALVMIGFETYLVIGFA-IVNGIGWTTYMATS 122
Cdd:cd17325 32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG------LLLLAVSTLLFAFATSYWQLLLArFLQGLASAAVWPAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 123 RSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLI-IAMTIMMFLISIFMLFRLHVDKPTHSEEESTN 201
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPfLVCAALALLALVLALLLLPEPRPPPNKRAVSA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 202 SLLQEyllGWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKI 281
Cdd:cd17325 186 ARLRS---GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 282 STKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTSI 351
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-317 |
2.88e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 76.50 E-value: 2.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 46 GIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIAlvmigFETYLVIGFAIVNGIGWTTYMATSRSL 125
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA-----HSPWLFAIALVLTGFGGGLFEPASEAM 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 126 VKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEESTNSllq 205
Cdd:cd17329 113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEI--- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 206 eyLLGWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKV 285
Cdd:cd17329 190 --LRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270
....*....|....*....|....*....|..
gi 587124954 286 LIFLLYFILVINSALFIWINSAFYLFIGSFIL 317
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVL 299
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-392 |
1.46e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.61 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 13 FFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIvi 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 93 alvMIGFETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAM 172
Cdd:cd06174 79 ---AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 173 TIM--MFLISIFMLFRLHVDKPTHSEEESTNSLLQEYLLGWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVLK 250
Cdd:cd06174 156 LIAaaLALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 251 LSSVQFGFSDMLYGIGGLCAGLISAILSKK-ISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMN 329
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 587124954 330 TAIMNTVSDKYVGRSFTIWTSISLLLQSLIAPFLGRWINEINDKFGFYIILILSLLIFVTLLL 392
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-338 |
1.22e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.08 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 44 LLGIMLALNVLSGFLASPIIGGLADKYN-----RRNIILITYLLQVILYLLI--VIALVMIGFETYLVIGFAIVnGIGWT 116
Cdd:COG2211 47 LVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLftAPDLSPTGKLIYALVTYLLL-GLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 117 TYMATSRSLVKQILK-PDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLIS----IFMLFRLHVDK 191
Cdd:COG2211 126 LVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAvlglLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 192 PTHSEEESTNSLLQeyllGWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAG 271
Cdd:COG2211 206 ERPVPEEEKVSLKE----SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 587124954 272 LISAILSKKISTKVLIFLLYFILVINSALFIWIN-SAFYLFIGSFILGYSISSIRIYMNTAIMNTVSD 338
Cdd:COG2211 282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVD 349
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-196 |
1.79e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.23 E-value: 1.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 1 MTDLLKIKNFRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQ-LLGIMLALNVLSGFLASPIIGGLADKYNRRNIILIT 79
Cdd:COG2211 221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAaLVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 80 YLLQVILYLLIVIALVMigfETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTD-------ANSLLEISLQTGMFI 152
Cdd:COG2211 301 LLLAALGLLLLFFLGPG---NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQAL 377
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 587124954 153 AGGLSGILYKINGFT---------------LIIAMTIMMFLISIFMLFRLHVDKPTHSE 196
Cdd:COG2211 378 AGALAGLLLALFGYVagaaqspsaltgirlLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
3-367 |
1.80e-10 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 62.30 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 3 DLLKI-KNFRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITY- 80
Cdd:PRK10489 11 SLLKThPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 81 ---LLQVILYL--------LIVIALVMigfetyLVIGFAivNGIGWTTYMATSRSLVKQilkpDQYTDANSLLEISLQTG 149
Cdd:PRK10489 91 tcgLGFIGLALnaflpepsLLAIYLLG------LWDGFF--GSLGVTALLAATPALVGR----ENLMQAGAITMLTVRLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 150 MFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEESTnslLQEYLLGWKFLKDNMMIfifGVISII 229
Cdd:PRK10489 159 SVISPALGGLLIAAGGVAWNYGLAAAGTFITLLPLLRLPALPPPPQPREHP---LRSLLAGFRFLLASPVV---GGIALL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 230 PMVFTMI--FNISLPGYVYNVLKLSSVQFGFsdmLYG---IGGLCAGLISAILSKKISTKVLIF---LLYFILVINSALF 301
Cdd:PRK10489 233 GGLLTMAsaVRVLYPALADEVWQMGAAQIGL---LYAavpLGAALGALTSGWLAHSARPGLLMLlstLGSFLAVGLFGLM 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 587124954 302 IWINSAFyLFIGSFILGYSISSIRIYmnTAIMNTVSDKYVGRSFTIWTSISLL---LQSLIAPFLGRWI 367
Cdd:PRK10489 310 PMWILAV-LCLALFGYLSAISSLLQY--TLLQTQTPDEMLGRINGLWTAQNVTgdaIGAALLGGLGAMM 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-187 |
3.88e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.05 E-value: 3.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 1 MTDLLKIKNFRLFFLAEIISAFGVGISTVGANWYLIDKTN-DSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILIT 79
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 80 YLLQVILYLLIVIALVMigfetYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGI 159
Cdd:cd17325 272 LLLSAVALLLLPLATSF-----WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
|
170 180
....*....|....*....|....*...
gi 587124954 160 LYKINGFTLIIAMTIMMFLISIFMLFRL 187
Cdd:cd17325 347 LYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
5-352 |
5.98e-10 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 60.92 E-value: 5.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 5 LKIKNFRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQV 84
Cdd:pfam05977 7 LRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 85 ILYLLIVIaLVMIGFET-YLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKI 163
Cdd:pfam05977 87 LVSTLLTL-LAGLGLLSpWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 164 NGFTLIIAMTIMMFLISIFMLFRLHVDKPthseeesTNSLLQEYLL-----GWKFLKDNMMI-------FIFGVISIIPM 231
Cdd:pfam05977 166 FGPAFTFALNALSYFAVIAALWRWKRAAP-------ASPLPRERIFgavraGLRFTAMSRELrsvlvraFAFGLSASAVW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 232 VFtmifnisLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLF 311
Cdd:pfam05977 239 AL-------LPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAI 311
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 587124954 312 IGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTSIS 352
Cdd:pfam05977 312 PVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVF 352
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
35-367 |
1.42e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 59.13 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 35 LIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMigfetYLVIGFAIVNGIG 114
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL-----WLLFLARFLDGLT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 115 wTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIfmlfrlhvdkpth 194
Cdd:cd17330 101 -GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNL------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 195 seeestnsllqeyLLGWKFLKDNMMIFIFGVISIIPMvftMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCA-GLI 273
Cdd:cd17330 167 -------------VLVLFFLPPLRRLLLVYFLIALAF---AGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 274 SAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTSISL 353
Cdd:cd17330 231 IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQS 310
|
330
....*....|....
gi 587124954 354 LLqSLIAPFLGRWI 367
Cdd:cd17330 311 LA-RIIGPLLAGPL 323
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
45-393 |
1.91e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.74 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 45 LGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIAlvmIGFETYLVIGFAIVNGIGwTTYMATSRS 124
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA---VSYWLLLLLGLLLGIGGG-GSFAVGIAL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 125 LVKqILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEESTNSLL 204
Cdd:COG2223 118 VSK-WFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 205 qEYLLGWKfLKDNMMIFIFGVISIIPMVFtmiFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTK 284
Cdd:COG2223 197 -DQLEALR-DPRFWLLSLLYFGTFGSFIG---FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 285 VLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIriyMNTAIMNTVSDKYVGRSFTIWTSISLLLQSLIAPFLG 364
Cdd:COG2223 272 RVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG---GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348
|
330 340
....*....|....*....|....*....
gi 587124954 365 RWINEINDKFGFYIILILSLLIFVTLLLV 393
Cdd:COG2223 349 LLFGALLDATGSYTAAFLVFAVLALVALV 377
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
2-187 |
1.93e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.82 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 2 TDLLKIKNFRLFFLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYL 81
Cdd:cd17355 204 KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 82 LQvilyLLIVIALVMIGFETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILY 161
Cdd:cd17355 284 LR----ALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
170 180
....*....|....*....|....*..
gi 587124954 162 KING-FTLIIAMTIMMFLISIFMLFRL 187
Cdd:cd17355 360 DRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-338 |
2.57e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 55.25 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 15 LAEIISAFGVGISTVGanwylidktndsqllgIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIAl 94
Cdd:cd17324 22 LPDIARDFGVSVAQAG----------------LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 95 vmIGFETYLVIGFAIvnGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGF-TLIIAMT 173
Cdd:cd17324 85 --PSFALLLLARALA--GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWrAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 174 IMMFLISIFMLFRLHVDKPTHSeeestnSLLQEYLLGWKFLKDNMMIFIFGVISIIPMVFTMIFNiSLPGYVYNVLKLSS 253
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKP------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYT-YLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 254 VQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIM 333
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
....*
gi 587124954 334 NTVSD 338
Cdd:cd17324 314 RLAPE 318
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-153 |
6.22e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 6.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 1 MTDLLKIKNFRLFFLAEIISAFGVGISTVGANWYLIDKTN-DSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILIT 79
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 587124954 80 YLLQVILYLLIVIALVMIgfetyLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIA 153
Cdd:COG2814 280 LLLLALGLLLLALAGSLW-----LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
1-311 |
9.56e-07 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 51.08 E-value: 9.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 1 MTDLLKIKNFRLFFLAEIISAF---GVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIIL 77
Cdd:PRK08633 2 MKNLLKIIGFLPLLLTQFLNAFndlGHKILIQNTLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 78 ITYLLQVILYLLIVIALVMIGFetYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLE----ISLQTGMFIA 153
Cdd:PRK08633 82 IVKLFEVGLTLLIVLAYYLGWF--WLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEaftiVAILAGTALF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 154 GGLSGILYKIN---GFTLIIAMTIMMFLISI---FMLFRLhvdkPTHSEEESTNSLLQEYLLG---WKFLK-----DNMM 219
Cdd:PRK08633 160 SFLFESVNGNTpseILGRIAPAGLVLLAVAVlglIFAYRL----PKVPAAAPEVFDKKKYLFPkllWRNLKllrsdRVLW 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 220 IFIFGvISIIPMVFTMIFnISLPGYVYNVLKLSSV-QFGFSDMLYGIgGLCAG-LISAILSK-KISTKVL------IFLL 290
Cdd:PRK08633 236 LAIIG-LSYFWFISQLAQ-ANFPAYAKEVLGLDNTfQVQYLLAASAI-GIGIGsLLAGRLSGrHIELGLVplgalgLALS 312
|
330 340
....*....|....*....|.
gi 587124954 291 YFILVINSALFiWINSAFYLF 311
Cdd:PRK08633 313 LFLLPTAPSLA-SVLVLFFLF 332
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-370 |
2.06e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 58 LASPIIGGLADKYNRRNIILITYLLqvilyllIVIALVMIGFET--YLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQY 135
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLPGLLL-------FGIGGLLCGLSDsfALLLAGRALQGIGAAGLGPLALTLIGDLFEGGER 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 136 TDANSLLEISLQTGM----FIAGGLSGILYKINGFTLIIAMTIMMFLISIFMlfrlhvdkptHSEEESTNSLLQEYLLGW 211
Cdd:cd17474 122 AKAMGLYEAALGLGIavgpLLGGLLAAISWRYPFFLLAALIPVAFLAILFLL----------PEPKEKAKSSSATKLRDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 212 KFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFsdmLYGIGGLCAGLISA----ILSKKISTKVLI 287
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL---LFAGWSVLLALGSLfvgrLLKKRFGARRIL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 288 FLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTSISLLLQSlIAPFLGRWI 367
Cdd:cd17474 269 VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQA-VGPLLFGLL 347
|
...
gi 587124954 368 NEI 370
Cdd:cd17474 348 LEI 350
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-363 |
3.25e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.69 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 44 LLGIMLALNVLSGFLASPIIGGLADKYNRR-NIILITYLLQVILYLLIVIALVMIgfetyLVIGFAIVNGIGWTTYMATS 122
Cdd:cd17370 35 AVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQ-----LVLLLRILERLGKGIRTPPR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 123 RSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGIL--YKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEEST 200
Cdd:cd17370 110 DALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKK 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 201 NSLLQEYLLGWKFLKDNMMIFIFGvisiipmvftmIFNISLPGYVYNVLKLSsVQFGFSDMLYGIGGL---CAGLISAIL 277
Cdd:cd17370 190 SKKTSLKKLPKAFWLYLLAVALFA-----------LGNFSFAFLILRAQELG-LSAALIPLLYALFNLvyaLAAYPAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 278 SKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRS---FTIWTSISLL 354
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAyglFNTVVGIGWL 337
|
....*....
gi 587124954 355 LQSLIAPFL 363
Cdd:cd17370 338 LASLIAGYL 346
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
44-324 |
4.48e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.32 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 44 LLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITyllqvILYLLIVIALVMIGFETYLVIGFAIVNGIGWTTYMATSR 123
Cdd:cd17478 32 QAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG-----PLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 124 SLVKQILKPDQYTdANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEESTNSL 203
Cdd:cd17478 107 RLASQAAGGRRGL-AMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 204 LQEYLLGWKFLkdnmMIFIFGVISIIPMVFtMIFNISLPGYvYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKIST 283
Cdd:cd17478 186 ARSTLKGVWRA----LLLLLIIVFLRSWVL-SSLTTFLPFY-LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 587124954 284 KVLIFLLYFILVINSALFIWINSAFY---LFIGSFILGYSISSI 324
Cdd:cd17478 260 RRVIIASLLLAAPFLLLFLLTPGIWSyilLVLAGFLLFASFPVT 303
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
44-298 |
4.70e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.31 E-value: 4.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 44 LLGIMLALNVLSGFLASPIIGGLADK-YNRRNIILITYLLQVILYLLIviaLVMIGFETYLVIGFAI--VNGIGWTTYMA 120
Cdd:cd17471 33 QIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLF---AFLRNYWVLLLVGVVLlsLGAAAFPQLFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 121 TSRSLVKQIlKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEEST 200
Cdd:cd17471 110 LAREYADRS-SGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 201 NSLLQEYLLGWKflkdnmMIFIFGVISIIPMVFTMiFNISLPGYVYNVLKLSSVQFGFsdmlygIGGLCAG------LIS 274
Cdd:cd17471 189 ASSLVKAPVNRR------LLLLFAAFTLLFAANSM-YIIAMPLYVTNELGGSESWVGL------LFGLAAAleipimLLA 255
|
250 260 270
....*....|....*....|....*....|
gi 587124954 275 AILSKKISTK------VLIFLLYFILVINS 298
Cdd:cd17471 256 GLLAKRFGKRrlllagFLAGVLFYLGLALA 285
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
45-395 |
5.12e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 5.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 45 LGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMIGFetylvIGFAIVNGIGWTTYMATSRS 124
Cdd:COG2271 47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL-----LLLRFLLGLGEAGFFPAALK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 125 LVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGF-TLIIAMTIMMFLISIFMLfrlhvdkpthseeestnsl 203
Cdd:COG2271 122 LIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWrAAFLILGLPGLLLALLRF------------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 204 lqeyllgwkflkdnMMIFIFGVISIIPMVFTMIFnisLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKI-- 281
Cdd:COG2271 183 --------------WLLALAYFLVYFALYGFLTW---LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgr 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 282 STKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTSISLLLQSLIAP 361
Cdd:COG2271 246 RRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL 325
|
330 340 350
....*....|....*....|....*....|....
gi 587124954 362 FLGRWINEINDKFGFYIILILSLLIFVTLLLVNK 395
Cdd:COG2271 326 LVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
41-367 |
6.24e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.01 E-value: 6.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 41 DSQLLGIMLALNVLSGFLASPIIGGLADKYN-----RRNIILityllqvILYLLIVIALVMIGFET-------------- 101
Cdd:cd17313 32 SHALIGFVWTLGPILGLFVQPLVGSLSDRCNsrigrRRPFIL-------VGAPLAALGLILIPNAAdiglalgdgprtwa 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 102 --YLVIGFAIVNgIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLI---------I 170
Cdd:cd17313 105 lvLFVLGIVLLD-FAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFAlggnlkvpfY 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 171 AMTIMMFLISIFMLFRLH-VDKPTHSEEESTNSLLQEYLLGWKFLKDNM---MIFIFGV-----ISIIPMV--FT--MIF 237
Cdd:cd17313 184 IGAIILLVCVLVTLFFVKePPLSPEAGEHSENPSLGEVLKSLLKLLKIMprsLLRLLLViffwwIAFFPFElfFTdyMGE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 238 NI----SLPGYVYNVlklsSVQFG-FSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFI 312
Cdd:cd17313 264 EVyhgtSAASSHYGA----GVRMGaWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALV 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 587124954 313 GSFILGYSISSIRI--YMNTAIMNTVSDKYVGRSFTIWTSISLLLQSLIAPFLGRWI 367
Cdd:cd17313 340 LFALGGIGWATINInpYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPII 396
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
8-185 |
7.22e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.54 E-value: 7.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 8 KNFRLFFLaeIISAFGVGISTVGANWYLIDKTNDSQLLGIML-ALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVIL 86
Cdd:cd17370 200 KAFWLYLL--AVALFALGNFSFAFLILRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 87 YLLIVIALVMigfeTYLVIGFAIVnGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGF 166
Cdd:cd17370 278 YLGFALGSSL----WLLLLGFILW-GLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISP 352
|
170
....*....|....*....
gi 587124954 167 TLIIAMTIMMFLISIFMLF 185
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-318 |
2.07e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 21 AFGVGISTVGAnwYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMIgfe 100
Cdd:cd17489 11 SFYLLLPVLPL--YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 101 tyLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLIS 180
Cdd:cd17489 86 --LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 181 IFMLFRLHVDKPTHSEEESTNSLLQEYLLGWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPgyvynvlklsSVQFGFSD 260
Cdd:cd17489 164 LLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERG----------ISNAGLFF 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 587124954 261 MLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILG 318
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYG 291
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-186 |
2.71e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 3 DLLKIKNFRLFFLAEIISAFG-VGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYL 81
Cdd:COG2223 200 EALRDPRFWLLSLLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 82 LQVIlyLLIVIALVMIGFETYLVIGFAIvnGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILY 161
Cdd:COG2223 280 LMAL--GLLLLALALGSLWLFLVLFLLL--GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
170 180 190
....*....|....*....|....*....|
gi 587124954 162 KING-----FTLIIAMTIMMFLISIFMLFR 186
Cdd:COG2223 356 DATGsytaaFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
58-365 |
3.46e-05 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 45.42 E-value: 3.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 58 LASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALvmigfETYLVIGFAIVNGIGwTTYMATSRSLVKQILKPDQYTD 137
Cdd:cd17396 50 LTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSP-----NLIIAYVFALLAGAA-NSFLDTGTYPALMEAFPKASGS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 138 ANSLLEISLQTGMFIAGGLSGILYKIN---GFTLIIaMTIMMFLISIFML---FRLHVDKPTHSEEESTNSLLQEYllgw 211
Cdd:cd17396 124 ANILVKAFVSFGQFLLPFIIAFLAANNlwyGWSFIV-PAAVLVLNALLLLklsFPPQTVTAANTKQKEIPVKREKP---- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 212 KFLKDNMMIFIFGVISiipMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLY 291
Cdd:cd17396 199 KFLIEGIALILIGFTS---TATFYLFSQWMPKYGSAVAGMGEAESLKLISYYSMGSLVCVFITAVLLKRYVRPIWILVLY 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 587124954 292 -FILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRS---FTIWTSISLLLQSLIAPFLGR 365
Cdd:cd17396 276 pIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLGLTLMAEFFPKGKGKVtgiYMIASSLANFVIPLITGIIAS 353
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
46-318 |
5.76e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.93 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 46 GIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMigfeTYLVIGfAIVNGIGWTTyMATSRSL 125
Cdd:cd17388 41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTL----WWLYLG-RIIAGITGAT-GAVAAAY 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 126 VKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKING---FTLIIAMTIMMFLISIFMLFRLHvdKPTHSEEESTNS 202
Cdd:cd17388 115 IADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPrapFLVAAGLNGLNFLLGLFVLPESL--PPERRRAFRWRR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 203 LLQEYLLGWKFLKDNMMIFI--FGVISIIPMVFTMIFNIslpgYVYNVLKLSSVQFGFSDMLYGI-GGLCAGLISAILSK 279
Cdd:cd17388 193 ANPFGSLRWLTGFPGLLGLLavFFLIQLIGQVPATTWVL----FTEDRFDWSPTMVGLSLAVFGLlHALFQAFVTGPIAK 268
|
250 260 270
....*....|....*....|....*....|....*....
gi 587124954 280 KISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILG 318
Cdd:cd17388 269 RLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLA 307
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
62-324 |
6.32e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 6.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 62 IIGGLADKYNRRNIILITYLLQVILYLLIVIAlvmIGFETYLVIGFaiVNGIGWTTYMATSRSLVKQILKPDQYTDANSL 141
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILASLLCALA---SSIEQLLIARF--LQGLGAAAGSVVARAIVRDLYSGAELAKIFSL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 142 LEISLQTGMFIAGGLSGILYKINGFTLI-IAMTIMMFLISIFMLFRLhvdkPTHSEEESTNSLLQEYLLGWKFLKDNMMI 220
Cdd:cd17320 128 LMMILAIAPALAPLLGGLLLLFFGWRAIfVFLALLGLLLLLLVLLFL----PETLPEEKRKPLLSSLLRAYKRVLKNRRF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 221 FIFGVISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSAL 300
Cdd:cd17320 204 LGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALV 283
|
250 260
....*....|....*....|....
gi 587124954 301 FIWINSAFYLFIGSFILGYSISSI 324
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPLFLIFF 307
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
46-237 |
6.57e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.88 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 46 GIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIvIALVMIGFETYLVIgfAIVNGIGWTTYMATSRSL 125
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLS-LFFVAQIFWLLLLL--VILGAFFSAPVVPLVDSI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 126 VKQIL--KPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEESTNSL 203
Cdd:cd17335 112 TLQYLgeERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGL 191
|
170 180 190
....*....|....*....|....*....|....
gi 587124954 204 LQeYLLGWKFLKDNMMIFIFGVISIIPMVFTMIF 237
Cdd:cd17335 192 LA-LLRNPRVLAFLLVAFLMGFGHGLIYSFLFWH 224
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
46-188 |
1.29e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 46 GIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLqvilyllIVIALVMIGFET--YLVIGFAIVNGIGWTTYMATSR 123
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL-------LALGLLLLSFAGspWMLLLAAVLYGLGFGLLFPALQ 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 587124954 124 SLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTIMMFLISIFMLFRLH 188
Cdd:cd17489 303 ALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-350 |
2.59e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 40 NDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMigfetYLVIGFAIVNGIGWTTYM 119
Cdd:cd17473 32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL-----YALLASRALLGIGVAGIM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 120 ATSRSLVKqilkpDQYTDANSLLEISLQTGMFIAGG-----LSGILYKINGFT--LIIAMTIMMFLISIFMLFrlhvDKP 192
Cdd:cd17473 107 TLATALIG-----DYFEGEERAKMLGLQSAAMSLGGvvfllLGGALAEIGWRApfLVYLLALPVLILVLLFLP----EPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 193 THSEEESTNSLLQEYLLGWKflkdnMMIFIFGVISIIPMVFTMIFnISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGL 272
Cdd:cd17473 178 RKSKSAASPGAATAAALPWK-----RVLPIYFLAFLAMLLFYVIP-IQLPFLLQERGGGSAALIGLALAIASLAGAIGAL 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 587124954 273 ISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTS 350
Cdd:cd17473 252 LFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
225-367 |
3.60e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 225 VISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWI 304
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 587124954 305 NSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWtSISLLLQSLIAPFLGRWI 367
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLL 144
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
42-187 |
4.37e-04 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 42.26 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 42 SQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYL-LIVIALVMIGFETYLVIGFAIVNGI--GWTTY 118
Cdd:cd17386 29 ANFYLYMNLMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLiLVLIVYFTTVPSVWWFYLSAIPLALfgGFTAF 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 587124954 119 MATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKING----FTLIIAMTIMMFLISIFMLFRL 187
Cdd:cd17386 109 LSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGyawsFSISAALLLIALLYILFFLTLL 181
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-188 |
6.80e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.34 E-value: 6.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 15 LAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIAL 94
Cdd:COG0477 21 LGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 95 VMIgfetyLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGFTLIIAMTI 174
Cdd:COG0477 101 SPE-----LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170
....*....|....
gi 587124954 175 MMFLISIFMLFRLH 188
Cdd:COG0477 176 PLGLLALVLRLRLP 189
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
45-324 |
1.64e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 45 LGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMIGFetylvIGFAIVNGIGWTTYMATSRS 124
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLL-----LLALFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 125 LVkQILKPDQYTDANSLLEISLQTGMFIAGGLSG--ILYKINGFTLIIAMTIMMFLISIFMLFRLHVDKPTHSEEESTNS 202
Cdd:COG0738 120 YV-AALGPETAASRLNLLHAFFSLGALLGPLLGGllILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 203 LLQEYLLGWKFLkdnmmIFIFGVISIIPMVFT-MIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKI 281
Cdd:COG0738 199 SAASLKSLLKNP-----RLLLGGLAIFLYVGAeGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 587124954 282 STKVLIFLLYFILVINSALFIWINSAFYLFIGSFILGYSISSI 324
Cdd:COG0738 274 GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-183 |
1.91e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 14 FLAEIISAFGVGISTVGANWYLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIA 93
Cdd:cd17477 194 LLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 94 lvmIGFETYLVIGFAIVNGIGWTTYmATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKING-FTLIIAM 172
Cdd:cd17477 274 ---PGLPLALLVLLFLWGGAAGPLY-TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGpHGLFLFL 349
|
170
....*....|.
gi 587124954 173 TIMMFLISIFM 183
Cdd:cd17477 350 AAVALLFLLFL 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
233-332 |
2.21e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 233 FTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLCAGLISAILSKKISTKVLIFLLYFILVINSALFIWINSAFYLFI 312
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100
....*....|....*....|
gi 587124954 313 GSFILGYSISSIRIYMNTAI 332
Cdd:COG0738 102 ALFLLGLGLGLLDVAANPYV 121
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
2-185 |
3.50e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.13 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 2 TDLLKIKNFRLFFLAEIISAFGvGISTVGaNWYLIDKTN---DSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILI 78
Cdd:cd17353 207 REMLRTPTFWLLWLMFFLNATA-GLMLIG-QAKPIGQEFaglDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 79 TYLLQVILYLLiviaLVMIGFETYLVIGFAIVNGIGWTTYMATSRSLVKQILKPDQYTDANSLLEISLQTGMFIAGGLSG 158
Cdd:cd17353 285 AFLIQGVAMFL----LPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA 360
|
170 180
....*....|....*....|....*...
gi 587124954 159 ILYKINGFT-LIIAMTIMMFLISIFMLF 185
Cdd:cd17353 361 YVLYTGGYNaAFIIAAALSLVALALALL 388
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
46-364 |
4.05e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 46 GIMLALNVLSGFLASPIIGGLADKYNRRNIilityLLQVILYLLIVIALVMIGFETYLVIGFAIVNGIgWTTYMATSRSL 125
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPM-----LLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 126 VKQILKPDQYTDANSLLEISLQTGMFIAGGLSGILYKINGF-TLIIAMTIMMFLISIFMLFRLHVD-KPTHSEEESTNSL 203
Cdd:cd17391 113 IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIrNVFFITGGLLFLAFLLTLFFVKEDfKPVEKKKMVSTKE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 204 LqeyllgWKFLKDNMMIFIFGVISIIPMVFTMIFNISLPGYVYNVLKLSSVQFGFSDMLYGIGGLcAGLISAILSKKIST 283
Cdd:cd17391 193 V------WNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGV-SSLLSAPRLGKLGD 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587124954 284 KV------LIFLLY-FILVINSALFiwiNSAFYLFIGSFILGYSISSIRIYMNTAIMNTVSDKYVGRSFTIWTSISLLLQ 356
Cdd:cd17391 266 RIghhrilLGALLAsALLYIPQAFV---QTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGN 342
|
....*...
gi 587124954 357 SlIAPFLG 364
Cdd:cd17391 343 V-AGPLLG 349
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-109 |
7.94e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 7.94e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 587124954 34 YLIDKTNDSQLLGIMLALNVLSGFLASPIIGGLADKYNRRNIILITYLLQVILYLLIVIALVMIGFETYLVIGFAI 109
Cdd:cd17478 221 YLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLL 296
|
|
| |
