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Conserved domains on  [gi|587244936|gb|EWV27889|]
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Staphylococcus aureus T67319]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 1-282 7.95e-127

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 362.13  E-value: 7.95e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQL 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  81 KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKP 160
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 161 PSAWVILAKPNLGISSPDIFKLINLDKRYD-VHTKMCYEALENRDyQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGA 239
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPpPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 587244936 240 DGALMSGSGPTVYGLARKESQAKNIYNAVNGCCnEVYLVRLLG 282
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 1-282 7.95e-127

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 362.13  E-value: 7.95e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQL 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  81 KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKP 160
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 161 PSAWVILAKPNLGISSPDIFKLINLDKRYD-VHTKMCYEALENRDyQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGA 239
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPpPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 587244936 240 DGALMSGSGPTVYGLARKESQAKNIYNAVNGCCnEVYLVRLLG 282
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 6-282 1.54e-94

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 280.55  E-value: 1.54e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936    6 APAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPsNHKNLAYRAAQLFIEQY----QLK 81
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVP-LEENLAYRAAQLLKNFAnskiKSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   82 QGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPP 161
Cdd:TIGR00154  86 DGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPFEDPP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  162 SAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADG 241
Cdd:TIGR00154 166 EKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEVAQALNWLLEYGLAP 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 587244936  242 ALMSGSGPTVYGLARKESQAKNIYN----AVNGCCNEVYLVRLLG 282
Cdd:TIGR00154 246 ERMSGSGPCVFALFDMESEAEQVLEqapeWLNGFVAKGYNVSPIG 290
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-261 1.01e-53

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 176.23  E-value: 1.01e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   5 TAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFhkRKDRKIVVEIE---HNYVPSNHKNLAYRAAQLFIEQYQLK 81
Cdd:PRK03188   4 RAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTV--TAADVLSVEVSgegADQVPTDESNLAWRAAELLAEHVGRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  82 QGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEK-IEFLNKP 160
Cdd:PRK03188  82 PDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQlAPVLARG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 161 PSAWViLAKPNLGISSPDIFKliNLDK--------RYDVHTKMcYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKN 232
Cdd:PRK03188 162 TFHWV-LAFADGGLSTPAVFR--ELDRlreagdppRLGEPDPL-LAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLR 237

                        250       260
                 ....*....|....*....|....*....
gi 587244936 233 NMLKSGADGALMSGSGPTVYGLARKESQA 261
Cdd:PRK03188 238 AGEEAGALAGIVSGSGPTCAFLCADADSA 266
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 85-141 4.17e-15

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 68.34  E-value: 4.17e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 587244936   85 TISIDKEIPVSAGLAGGSADAAATLRGLNRLF-----DIGASLEELALLGSKIGTDIPFCIY 141
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGGRGGGMDVAASLY 62
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 1-282 7.95e-127

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 362.13  E-value: 7.95e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQL 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDEDNLVYRAARLLQEATGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  81 KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKP 160
Cdd:COG1947   81 PPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 161 PSAWVILAKPNLGISSPDIFKLINLDKRYD-VHTKMCYEALENRDyQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGA 239
Cdd:COG1947  161 PELWLVLVKPGVGVSTAEVYRALDLTRDTPpPDIDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEALLEAGA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 587244936 240 DGALMSGSGPTVYGLARKESQAKNIYNAVNGCCnEVYLVRLLG 282
Cdd:COG1947  240 LAARMSGSGSTVFGLFEDEEAAEAAAAALPARG-GVFVARTLN 281
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 6-282 1.54e-94

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 280.55  E-value: 1.54e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936    6 APAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPsNHKNLAYRAAQLFIEQY----QLK 81
Cdd:TIGR00154   7 APAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVP-LEENLAYRAAQLLKNFAnskiKSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   82 QGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPP 161
Cdd:TIGR00154  86 DGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPFEDPP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  162 SAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADG 241
Cdd:TIGR00154 166 EKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAKEWLKKISLECLQLLDSNGLNDLEKVALKRHTEVAQALNWLLEYGLAP 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 587244936  242 ALMSGSGPTVYGLARKESQAKNIYN----AVNGCCNEVYLVRLLG 282
Cdd:TIGR00154 246 ERMSGSGPCVFALFDMESEAEQVLEqapeWLNGFVAKGYNVSPIG 290
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 5-261 1.01e-53

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 176.23  E-value: 1.01e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   5 TAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFhkRKDRKIVVEIE---HNYVPSNHKNLAYRAAQLFIEQYQLK 81
Cdd:PRK03188   4 RAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTV--TAADVLSVEVSgegADQVPTDESNLAWRAAELLAEHVGRA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  82 QGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEK-IEFLNKP 160
Cdd:PRK03188  82 PDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQlAPVLARG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 161 PSAWViLAKPNLGISSPDIFKliNLDK--------RYDVHTKMcYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKN 232
Cdd:PRK03188 162 TFHWV-LAFADGGLSTPAVFR--ELDRlreagdppRLGEPDPL-LAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLR 237

                        250       260
                 ....*....|....*....|....*....
gi 587244936 233 NMLKSGADGALMSGSGPTVYGLARKESQA 261
Cdd:PRK03188 238 AGEEAGALAGIVSGSGPTCAFLCADADSA 266
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-262 2.95e-49

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 164.64  E-value: 2.95e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVV------EIehnyvPSNHKNLAYRAAQLF 74
Cdd:PRK14608   6 SLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAEALSLTVsgpfaaGL-----GDGDDNLVLRAARAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  75 IEQYQ-LKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEK 153
Cdd:PRK14608  81 RARVGpGLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 154 IEFLNKPPSAWVILAKPNLGISSPDIFKliNLDKRYDVHTKMCYEALENRDyqQLCQSLS---NRLEPISVSKHPQI-DK 229
Cdd:PRK14608 161 LTPLPGLPSLPAVLVNPGVPVATPDVFR--ALGLRDGPPLPGAPDPLASAD--ALLAALAatrNDLEPPALALAPVIgEV 236

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 587244936 230 LknNMLkSGADGAL---MSGSGPTVYGLARKESQAK 262
Cdd:PRK14608 237 L--AAL-RAQPGALlarMSGSGATCFALFADEAAAE 269
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
1-264 3.18e-40

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 140.66  E-value: 3.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFhkrkDRKIVVEIEHNyVP--SNHKNLAYRAAQLFIEQY 78
Cdd:PRK14611   1 MEVLLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYI----KEHHTLEVKTS-SPqiKEEENIVYKALRLFERYT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  79 QLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLN 158
Cdd:PRK14611  76 GIDINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 159 KPPSAWVILAKPNLGISSPDIFKLIN---LDKRYDVHTKMcyEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKnNML 235
Cdd:PRK14611 156 KPISREITLVYPNIKSSTGRVYSKVTkqiLTNKEDLNIII--SLLREGEEKKIEEVIENTLGEIALELYPEIKEVY-RFL 232

                        250       260
                 ....*....|....*....|....*....
gi 587244936 236 KSGADGALMSGSGPTVYGLARKESQAKNI 264
Cdd:PRK14611 233 EYLGYKPFVSGSGSSVYVFGKPSEEVKKA 261
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
6-258 1.34e-28

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 110.76  E-value: 1.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   6 APAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHK-------------NLAYRAAQ 72
Cdd:PRK14613   3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFSTNEIILEKRKlydqvsergdikqNILYKTFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  73 LFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASlEELALLGSKIGTDIPFCIYNKTALCTGRGE 152
Cdd:PRK14613  83 KARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFSWRNFFTS-DEMQVFAKEIGSDVPFFLGEGHAFVTGKGE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 153 KIEFLNKPPsAWVILAKPNLGISSPDIFKLIN--LDKRY-----DVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHP 225
Cdd:PRK14613 162 IMEEIEVHK-GQGILALTPQVMNTGEMYALLKkpLQESAsqkngNTLSEDLISSLKVGDWVSLQGRLENDFEPVAFQLHP 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 587244936 226 QIDKLKNNMLKSGADGALMSGSGPTVYGLARKE 258
Cdd:PRK14613 241 ELGVLKDKFLEFGSSYCSLTGSGSSMYGLVQGL 273
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 8-258 6.05e-25

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 100.04  E-value: 6.05e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   8 AKINFTLDTLFKRnDGYHEIEMIMTTV-DLNDRLTFhkRKDRKIVVEIEHNYVPSNHKNLAYRAAQ-LFIEQYQLK---- 81
Cdd:PRK04181   7 AKVNIFLKILGKR-GNYHELISRFVLVkDLFDEIEF--VPKSAESFELIGNFDCPLEENIIYKAYQeLKNKGFSNElief 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  82 -QGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYN-KTALCTGRGEKIE-FLN 158
Cdd:PRK04181  84 fKKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEeFEE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 159 KPPSAWVIlaKPNLGISSPDIFKL----------INLDKRYDvhTKMCYEALENRDYqqlcQSLSNRLEPiSVSKHPQid 228
Cdd:PRK04181 164 EILNLEIF--TPNIFCSTKAVYKAyreefydfisFNQAKELL--KLSSLELLKNFKN----TELNDLLAP-ALKLYPA-- 232

                        250       260       270
                 ....*....|....*....|....*....|.
gi 587244936 229 klknnmLKSGA-DGALMSGSGPTVYGLARKE 258
Cdd:PRK04181 233 ------LKDYLgEDWFFSGSGSSFFRVKRAQ 257
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 34-268 4.86e-20

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 87.46  E-value: 4.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  34 VDLNDRLTFHKRKDRKIVVEIE---HNYVPSNHKNLAYRAAQLFIEQY-QLKQGVTISIDKEIPVSAGLaGGSADA-AAT 108
Cdd:COG0083   25 LSLYDEVEVERSDEPGLEIEIEgegADELPTDEDNLVYQAALALLEKLgKEPPGLRIEIEKGIPLGRGL-GSSAAAiVAG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 109 LRGLNRLFDIGASLEEL----------------ALLGSkigtdipFCIynktalCTGRGEKIEFLNKPPSA--WVILAKP 170
Cdd:COG0083  104 LVAANALLGLPLSKEELlelategeghpdnvapALLGG-------LVL------SRSDGEPVRVVRLPVPPdlKAVVVIP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 171 NLGIS---SPDIfklinLDKRYD--------------VHtkmcyeALENRDYQQLCQSLSNRL-EPISVSKHPQIDKLKN 232
Cdd:COG0083  171 DFELStkeARAV-----LPKQVPlkdavfnssraallVA------ALATGDYELLGRAMEDRLhEPYRAKLIPGFDEVKE 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 587244936 233 NMLKSGADGALMSGSGPTVYGLARKEsQAKNIYNAV 268
Cdd:COG0083  240 AALEAGALGAGISGAGPTVLALADDE-EAEAVAEAM 274
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 30-248 8.26e-16

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 75.26  E-value: 8.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  30 IMTTVDLNDRLTFHKRKDRKIVVEIEH-----NYVPSNHKNLAY--RAAQLFIEQYQLK-QGVTISIDKEIPVSAGLAGG 101
Cdd:COG1577   20 IAVAVDRRATVTVEPSDDDKLRIESPDlggtlDLDPLADAALRYikAAIEAALEYLGLPlKGFDIEIDSEIPRKRGLGSS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 102 SADAAATLRGLNRLFDIGASLEELALLGSKI---------GTDIpFCIYNKTALCTGRGEKIEFLNKPPSAWVILAkpNL 172
Cdd:COG1577  100 AAVAVAVIRALAAFYGVELSKEELFKLALEAekivhgnpsGLDT-AASTYGGPIYYQRGDRAEPLELPKNLPLVVG--DT 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 173 GISSP--------------DIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLS-NR--LEPISVSkHPQIDKLKNNML 235
Cdd:COG1577  177 GVPAStkelvakvrklkerNPELYEAFLEEIGDLVEEAIEALEEGDLEALGELMNeNHglLRALGVS-TPELDRLVEAAR 255

                        250
                 ....*....|...
gi 587244936 236 KSGADGALMSGSG 248
Cdd:COG1577  256 KAGALGAKLTGAG 268
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 85-141 4.17e-15

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 68.34  E-value: 4.17e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 587244936   85 TISIDKEIPVSAGLAGGSADAAATLRGLNRLF-----DIGASLEELALLGSKIGTDIPFCIY 141
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGGRGGGMDVAASLY 62
PRK01212 PRK01212
homoserine kinase; Provisional
 34-268 6.50e-14

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 70.18  E-value: 6.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  34 VDLNDRLTFHKRKDRKIVVEIEH-----NYVPSN-HKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLaGGSADAA- 106
Cdd:PRK01212  26 LSLYDEVLVGDVVSVEAEFSIEVigegaDKLPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPLGRGL-GSSAASIv 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 107 ATLRGLNRLFDIGASLEEL----------------ALLGskigtdipfciyNKTALCTGRGEKIEFLNKPPSAWVILAKP 170
Cdd:PRK01212 105 AGLVAANELAGLPLSKEELlqlategeghpdnvapALLG------------GLVLALEENGVISVKIPVFDDLKWVVAIP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 171 NLGISSPDIFKLinLDKRYD--------------VHtkmcyeALENRDYQQLCQSLSNRL-EP-----IsvskhPQIDKL 230
Cdd:PRK01212 173 NIELSTAEARAV--LPKQYSlkdavfnssraallVA------ALYTGDYELAGRAMKDVLhEPyraklI-----PGFAEV 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 587244936 231 KNNMLKSGADGALMSGSGPTVYGLARKEsQAKNIYNAV 268
Cdd:PRK01212 240 RQAALEAGALGAGISGAGPTVFALCDKE-DAEKVADAL 276
PRK03926 PRK03926
mevalonate kinase; Provisional
 1-132 2.58e-13

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 68.54  E-value: 2.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPAKInftldTLFkrndGYHEI----EMIMTTVDLNDRLTFhKRKDRKIVveIEHNYVPSNHKNLAYRAAQLFIE 76
Cdd:PRK03926   1 MVLCSAPGKI-----YLF----GEHAVvygkPAIACAIDLRTYVRA-EFNDDSIY--IESDYGKTGEKHPYVSAAIEKMR 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 587244936  77 QYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKI 132
Cdd:PRK03926  69 EEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKV 124
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 64-258 2.33e-11

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 62.80  E-value: 2.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   64 KNLAYRAAQLFIEQYQLKQ-GVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEEL---ALLGSKIGTDIPFC 139
Cdd:TIGR00191  60 DNLIYQVAKRFLDQLGIRMpPVKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLldyASELEGHPDNVAPA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  140 IYNKTALCTGRGEKIEFLNKP-PSAW-VILAKPNLGISSPDIFKLinLDKRYDV--------HTKMCYEALENRDYQQLC 209
Cdd:TIGR00191 140 LLGGFQLAFVEDDKLEVLKIPiFSKLdWVLAIPNIEVSTAEARAV--LPKAYPRqdlvfnlsHLAGLVHAIYQKKPDLGA 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 587244936  210 QSLSNRL-EPISVSKHPQIDKLKNNMLKSGADGALMSGSGPTVYGLARKE 258
Cdd:TIGR00191 218 IMMKDRIhQPYRESLIPNLFKIKQAALEKGAYGITISGSGPTILAMADEE 267
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 61-174 5.72e-09

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 55.63  E-value: 5.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  61 SNHKNLAYRAAQLFIEQYQL-KQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKI----GTd 135
Cdd:COG4542   47 PAERPKARRAAELTLEHLGLpPLGGRIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAIeptdST- 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 587244936 136 ipfcIYNKTALCT-GRGEKIEFLNKPPSAWVILAKPNLGI 174
Cdd:COG4542  126 ----MFPGLVLFDhREGRVLEPLGPLPPLDILGLDSGGTV 161
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
1-250 6.66e-08

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 52.54  E-value: 6.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936   1 MIYETAPaKINFTLDTLFKR-NDGYHEIEMIMTTV-DLNDRLTFHKRKdrKIVVEIehNYVPSNHKNLAY------RAAQ 72
Cdd:PRK05905   1 MKYKSYA-KINLGLSIYKKCkKVTKHKLESIFILVeNVYDDIEIEKIE--KNIDDI--HYFDETNEILVYsrlilvKTLE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936  73 LFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGA-SLEELALlgsKIGTDIPFCIYN-KTALCTGR 150
Cdd:PRK05905  76 WLRDKYNIKNHFKIKIKKRIPIGSGLGSGSSNAAVLMKWILEFEGINEiNYKDVVN---KLGSDIPFFLSGyKTAYISDY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587244936 151 GEKIEFLNKPPSAWVILAKPNLGISSPDIFKLinldkrYDVHTKMCYEALENRDY---QQLCQSLSNRLEPISVSKHPQI 227
Cdd:PRK05905 153 GSQVEDLIGQFKLTYKVIFMNVNVSTKKVFEK------FDDNQHVIKNNFKTIIKnlkENIVVNIHNDLQEPCFELYPNL 226

                        250       260
                 ....*....|....*....|...
gi 587244936 228 dKLKNNMLKSGADGALMSGSGPT 250
Cdd:PRK05905 227 -LYKYNELLNDGFYTILSGAGSS 248
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 198-269 3.00e-07

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 47.46  E-value: 3.00e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 587244936  198 EALENRDYQQLCQSLS---NRLEPISVSK--HPQIDKLKNNMLKSGAdGALMSGS--GPTVYGLARKESQAKNIYNAVN 269
Cdd:pfam08544   3 EALLRGDLEELGKLLTesaESLEPLLVVGilPPELDELLEALLELGL-GAKLSGSggGPTVFALFKDEDDAEEVARALR 80
PRK03817 PRK03817
galactokinase; Provisional
 82-131 8.76e-04

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 40.36  E-value: 8.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 587244936  82 QGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSK 131
Cdd:PRK03817  85 GGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLARE 134
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
82-129 2.66e-03

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 38.98  E-value: 2.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 587244936  82 QGVTISIDKEIPVSAGLaggSADAA---ATLRGLNRLFDIGASLEELALLG 129
Cdd:COG0153  107 GGFDLVIDGDVPLGAGL---SSSAAlevAVALALNDLFGLGLDPVELAKIG 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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