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Conserved domains on  [gi|587331497|gb|EWW13419|]
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serine-rich adhesin for platelets [Staphylococcus aureus H38239]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bact_lectin pfam18483
Bacterial lectin; This entry primarily matches to legume-like lectin domains found in ...
 261-489 1.02e-57

Bacterial lectin; This entry primarily matches to legume-like lectin domains found in prokaryotes.


:

Pssm-ID: 465784  Cd Length: 211  Bit Score: 199.21  E-value: 1.02e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   261 VNKDNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYeGHGNGGDGIGFAFSPGv 340
Cdd:pfam18483    1 VTKDNFLDYFNLNGDATKQNYNGIVTLTPDQNGQSGAVTLKNKIDLNKDFTLKGAVNLGNKQ-SNTGGADGIGFVFHPG- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   341 lGETGLNGAAVGIGGLSNAFGFKLDTYHNTSKPNSaakaNADPSNVAGGGAFGAFVTTDSYGVATTYTSSSTADNAAKLN 420
Cdd:pfam18483   79 -GGIGTSGGGLGIGGLPNAFGFKFDTYYNSGDSDP----NADPSQGAGGDPYGAFVTTDSNGNLTDVGSDSQTGSTQALD 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 587331497   421 VQPTNNTFQDFDINYNGDTKVMTVKYAGQTWTrnisdwiaksgTTNFSLSMTASTGGATNLQQVQFGTF 489
Cdd:pfam18483  154 SSLEDGAFHPITISYDANTKTLTVTYDGNDSS-----------STKVYFGFAASTGGSTNLQQFKITSL 211
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
2132-2174 2.12e-06

LPXTG cell wall anchor motif;


:

Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 46.38  E-value: 2.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 587331497  2132 TPAQSEKRLPDTGDSIKQNGLLGGVMTLLVGLGLMKRKKKKDE 2174
Cdd:pfam00746    1 AKKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKEK 43
KxYKxGKxW_sig pfam19258
KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as ...
 14-50 6.56e-06

KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK signal peptide.


:

Pssm-ID: 466014 [Multi-domain]  Cd Length: 41  Bit Score: 44.79  E-value: 6.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 587331497    14 NEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHS 50
Cdd:pfam19258    1 ERKTHYKMYKSGKHWVFAGITTLGLGLGLLGGTTAAA 37
He_PIG pfam05345
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ...
 577-660 2.04e-05

Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.


:

Pssm-ID: 398814 [Multi-domain]  Cd Length: 95  Bit Score: 45.15  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   577 PTVTVGNQTIEVGKTMNPVVLTTTDNGTGTVTNTVTGLPSGLSYDSATNSIIGTP--TKIGQSTVTVVSTDQANNKSTTT 654
Cdd:pfam05345   10 QTATVGTPYSFTLSASGGSDPYGGSTVTYSTTATGGALPSGLTLNSSTGTISGTPtsVQPGTYTFTVTATDSSGLSSSTT 89


                   ....*.
gi 587331497   655 FKYEVT 660
Cdd:pfam05345   90 FTLTVT 95
ser_rich_anae_1 super family cl41472
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 662-929 6.86e-05

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


The actual alignment was detected with superfamily member NF033849:

Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 48.46  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  662 NSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLV 741
Cdd:NF033849  241 TGYGESVGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTT 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  742 NSQSVSSSMSGSVSKSTSLSDSISNSNSteKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTSISGSSSTSAS 821
Cdd:NF033849  321 DSSSHSQSSSYNVSSGTGVSSSHSDGTS--QSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSSGVSGGFSGGIA 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  822 LSDSTSNAISTSTSLSE---SASTSDSISISNSIANSQSASTSKSDSQSTSISLSTSDSKSMSTSESLSDSTSTSGSVSG 898
Cdd:NF033849  399 GGGVTSEGLGASQGGSEgwgSGDSVQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQSVGT 478

                         250       260       270
                  ....*....|....*....|....*....|.
gi 587331497  899 SLSIAASQSVSTSTSDSMSTSEIVSDSISTS 929
Cdd:NF033849  479 SESWSTSQSETDSVGDSTGTSESVSQGDGRS 509
 
Name Accession Description Interval E-value
Bact_lectin pfam18483
Bacterial lectin; This entry primarily matches to legume-like lectin domains found in ...
 261-489 1.02e-57

Bacterial lectin; This entry primarily matches to legume-like lectin domains found in prokaryotes.


Pssm-ID: 465784  Cd Length: 211  Bit Score: 199.21  E-value: 1.02e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   261 VNKDNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYeGHGNGGDGIGFAFSPGv 340
Cdd:pfam18483    1 VTKDNFLDYFNLNGDATKQNYNGIVTLTPDQNGQSGAVTLKNKIDLNKDFTLKGAVNLGNKQ-SNTGGADGIGFVFHPG- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   341 lGETGLNGAAVGIGGLSNAFGFKLDTYHNTSKPNSaakaNADPSNVAGGGAFGAFVTTDSYGVATTYTSSSTADNAAKLN 420
Cdd:pfam18483   79 -GGIGTSGGGLGIGGLPNAFGFKFDTYYNSGDSDP----NADPSQGAGGDPYGAFVTTDSNGNLTDVGSDSQTGSTQALD 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 587331497   421 VQPTNNTFQDFDINYNGDTKVMTVKYAGQTWTrnisdwiaksgTTNFSLSMTASTGGATNLQQVQFGTF 489
Cdd:pfam18483  154 SSLEDGAFHPITISYDANTKTLTVTYDGNDSS-----------STKVYFGFAASTGGSTNLQQFKITSL 211
lectin_L-type cd01951
legume lectins; The L-type (legume-type) lectins are a highly diverse family of carbohydrate ...
 264-491 1.79e-22

legume lectins; The L-type (legume-type) lectins are a highly diverse family of carbohydrate binding proteins that generally display no enzymatic activity toward the sugars they bind. This family includes arcelin, concanavalinA, the lectin-like receptor kinases, the ERGIC-53/VIP36/EMP46 type1 transmembrane proteins, and an alpha-amylase inhibitor. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.


Pssm-ID: 173886 [Multi-domain]  Cd Length: 223  Bit Score: 98.27  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  264 DNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYeghGNGGDGIGFAFSPGVLGE 343
Cdd:cd01951    10 NNNQSNWQLNGSATLTTDSGVLRLTPDTGNQAGSAWYKTPIDLSKDFTTTFKFYLGTKG---TNGADGIAFVLQNDPAGA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  344 TGLNGA--AVGIGGLSNAFGFKLDTYHNtskpnsaaKANADPSNvaggGAFGAFVTTDSYGVATTYTSSSTAdnaakLNV 421
Cdd:cd01951    87 LGGGGGggGLGYGGIGNSVAVEFDTYKN--------DDNNDPNG----NHISIDVNGNGNNTALATSLGSAS-----LPN 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 587331497  422 QPTNNTFQDFDINYNGDTKVMTV--KYAGQTWTRNIS--DWIAKSGTTNFSLSMTASTGGATNLQQVQFGTFEY 491
Cdd:cd01951   150 GTGLGNEHTVRITYDPTTNTLTVylDNGSTLTSLDITipVDLIQLGPTKAYFGFTASTGGLTNLHDILNWSFTS 223
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
2132-2174 2.12e-06

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 46.38  E-value: 2.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 587331497  2132 TPAQSEKRLPDTGDSIKQNGLLGGVMTLLVGLGLMKRKKKKDE 2174
Cdd:pfam00746    1 AKKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKEK 43
KxYKxGKxW_sig pfam19258
KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as ...
 14-50 6.56e-06

KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK signal peptide.


Pssm-ID: 466014 [Multi-domain]  Cd Length: 41  Bit Score: 44.79  E-value: 6.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 587331497    14 NEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHS 50
Cdd:pfam19258    1 ERKTHYKMYKSGKHWVFAGITTLGLGLGLLGGTTAAA 37
He_PIG pfam05345
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ...
 577-660 2.04e-05

Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.


Pssm-ID: 398814 [Multi-domain]  Cd Length: 95  Bit Score: 45.15  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   577 PTVTVGNQTIEVGKTMNPVVLTTTDNGTGTVTNTVTGLPSGLSYDSATNSIIGTP--TKIGQSTVTVVSTDQANNKSTTT 654
Cdd:pfam05345   10 QTATVGTPYSFTLSASGGSDPYGGSTVTYSTTATGGALPSGLTLNSSTGTISGTPtsVQPGTYTFTVTATDSSGLSSSTT 89


                   ....*.
gi 587331497   655 FKYEVT 660
Cdd:pfam05345   90 FTLTVT 95
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 662-929 6.86e-05

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 48.46  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  662 NSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLV 741
Cdd:NF033849  241 TGYGESVGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTT 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  742 NSQSVSSSMSGSVSKSTSLSDSISNSNSteKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTSISGSSSTSAS 821
Cdd:NF033849  321 DSSSHSQSSSYNVSSGTGVSSSHSDGTS--QSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSSGVSGGFSGGIA 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  822 LSDSTSNAISTSTSLSE---SASTSDSISISNSIANSQSASTSKSDSQSTSISLSTSDSKSMSTSESLSDSTSTSGSVSG 898
Cdd:NF033849  399 GGGVTSEGLGASQGGSEgwgSGDSVQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQSVGT 478

                         250       260       270
                  ....*....|....*....|....*....|.
gi 587331497  899 SLSIAASQSVSTSTSDSMSTSEIVSDSISTS 929
Cdd:NF033849  479 SESWSTSQSETDSVGDSTGTSESVSQGDGRS 509
KxYKxGKxW TIGR03715
KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as ...
 16-33 1.00e-03

KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK and PEP-CTERM forms of signal peptide. This domain tends to occur on long, low-complexity (usually Serine-rich and heavily glycosylated) proteins of the Firmicutes, and (as with YSIRK) the majority of these proteins have the LPXTG cell wall-anchoring motif at the C-terminus.


Pssm-ID: 274741 [Multi-domain]  Cd Length: 23  Bit Score: 38.14  E-value: 1.00e-03
                           10
                   ....*....|....*...
gi 587331497    16 KTRVRLYKSGKNWVKSGI 33
Cdd:TIGR03715    1 KKRYKMYKSGKHWVFAGI 18
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 635-879 2.04e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 43.46  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  635 GQSTVTVVSTDQANNKSTTTFKYEVTRNSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSL 714
Cdd:NF033849  242 GYGESVGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTTD 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  715 SDSVSASKSLSTSESNSVSSSTSTSLVNSQSVSSSMSGSVSKSTSLSDSISNSNSTEKSESLSTSTSDSLRTSTS----- 789
Cdd:NF033849  322 SSSHSQSSSYNVSSGTGVSSSHSDGTSQSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSSGVSGGFSGGiaggg 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  790 -LSDSLSMSTSGSLSKS-----QSLSTSISGSSSTSASLSDSTSNAISTSTSLSESASTSDSISISNSIANSQSASTSKS 863
Cdd:NF033849  402 vTSEGLGASQGGSEGWGsgdsvQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQSVGTSES 481

                         250
                  ....*....|....*.
gi 587331497  864 DSQSTSISLSTSDSKS 879
Cdd:NF033849  482 WSTSQSETDSVGDSTG 497
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 2139-2173 3.88e-03

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 36.68  E-value: 3.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 587331497  2139 RLPDTGDSIKQNGLLGGVMtLLVGLGLMKRKKKKD 2173
Cdd:TIGR01167    1 KLPKTGESGNSLLLLLGLL-LLGLGGLLLRKRKKK 34
 
Name Accession Description Interval E-value
Bact_lectin pfam18483
Bacterial lectin; This entry primarily matches to legume-like lectin domains found in ...
 261-489 1.02e-57

Bacterial lectin; This entry primarily matches to legume-like lectin domains found in prokaryotes.


Pssm-ID: 465784  Cd Length: 211  Bit Score: 199.21  E-value: 1.02e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   261 VNKDNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYeGHGNGGDGIGFAFSPGv 340
Cdd:pfam18483    1 VTKDNFLDYFNLNGDATKQNYNGIVTLTPDQNGQSGAVTLKNKIDLNKDFTLKGAVNLGNKQ-SNTGGADGIGFVFHPG- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   341 lGETGLNGAAVGIGGLSNAFGFKLDTYHNTSKPNSaakaNADPSNVAGGGAFGAFVTTDSYGVATTYTSSSTADNAAKLN 420
Cdd:pfam18483   79 -GGIGTSGGGLGIGGLPNAFGFKFDTYYNSGDSDP----NADPSQGAGGDPYGAFVTTDSNGNLTDVGSDSQTGSTQALD 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 587331497   421 VQPTNNTFQDFDINYNGDTKVMTVKYAGQTWTrnisdwiaksgTTNFSLSMTASTGGATNLQQVQFGTF 489
Cdd:pfam18483  154 SSLEDGAFHPITISYDANTKTLTVTYDGNDSS-----------STKVYFGFAASTGGSTNLQQFKITSL 211
lectin_L-type cd01951
legume lectins; The L-type (legume-type) lectins are a highly diverse family of carbohydrate ...
 264-491 1.79e-22

legume lectins; The L-type (legume-type) lectins are a highly diverse family of carbohydrate binding proteins that generally display no enzymatic activity toward the sugars they bind. This family includes arcelin, concanavalinA, the lectin-like receptor kinases, the ERGIC-53/VIP36/EMP46 type1 transmembrane proteins, and an alpha-amylase inhibitor. L-type lectins have a dome-shaped beta-barrel carbohydrate recognition domain with a curved seven-stranded beta-sheet referred to as the "front face" and a flat six-stranded beta-sheet referred to as the "back face". This domain homodimerizes so that adjacent back sheets form a contiguous 12-stranded sheet and homotetramers occur by a back-to-back association of these homodimers. Though L-type lectins exhibit both sequence and structural similarity to one another, their carbohydrate binding specificities differ widely.


Pssm-ID: 173886 [Multi-domain]  Cd Length: 223  Bit Score: 98.27  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  264 DNLKQYMTTSGNATYDQSTGIVTLTQDAYSQKGAITLGTRIDSNKSFHFSGKVNLGNKYeghGNGGDGIGFAFSPGVLGE 343
Cdd:cd01951    10 NNNQSNWQLNGSATLTTDSGVLRLTPDTGNQAGSAWYKTPIDLSKDFTTTFKFYLGTKG---TNGADGIAFVLQNDPAGA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  344 TGLNGA--AVGIGGLSNAFGFKLDTYHNtskpnsaaKANADPSNvaggGAFGAFVTTDSYGVATTYTSSSTAdnaakLNV 421
Cdd:cd01951    87 LGGGGGggGLGYGGIGNSVAVEFDTYKN--------DDNNDPNG----NHISIDVNGNGNNTALATSLGSAS-----LPN 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 587331497  422 QPTNNTFQDFDINYNGDTKVMTV--KYAGQTWTRNIS--DWIAKSGTTNFSLSMTASTGGATNLQQVQFGTFEY 491
Cdd:cd01951   150 GTGLGNEHTVRITYDPTTNTLTVylDNGSTLTSLDITipVDLIQLGPTKAYFGFTASTGGLTNLHDILNWSFTS 223
Gram_pos_anchor pfam00746
LPXTG cell wall anchor motif;
2132-2174 2.12e-06

LPXTG cell wall anchor motif;


Pssm-ID: 366278 [Multi-domain]  Cd Length: 43  Bit Score: 46.38  E-value: 2.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 587331497  2132 TPAQSEKRLPDTGDSIKQNGLLGGVMTLLVGLGLMKRKKKKDE 2174
Cdd:pfam00746    1 AKKSKKKTLPKTGENSNIFLTAAGLLALLGGLLLLVKRRKKEK 43
KxYKxGKxW_sig pfam19258
KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as ...
 14-50 6.56e-06

KxYKxGKxW signal peptide; This entry represents a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK signal peptide.


Pssm-ID: 466014 [Multi-domain]  Cd Length: 41  Bit Score: 44.79  E-value: 6.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 587331497    14 NEKTRVRLYKSGKNWVKSGIKEIEMFKIMGLPFISHS 50
Cdd:pfam19258    1 ERKTHYKMYKSGKHWVFAGITTLGLGLGLLGGTTAAA 37
He_PIG pfam05345
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ...
 577-660 2.04e-05

Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.


Pssm-ID: 398814 [Multi-domain]  Cd Length: 95  Bit Score: 45.15  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497   577 PTVTVGNQTIEVGKTMNPVVLTTTDNGTGTVTNTVTGLPSGLSYDSATNSIIGTP--TKIGQSTVTVVSTDQANNKSTTT 654
Cdd:pfam05345   10 QTATVGTPYSFTLSASGGSDPYGGSTVTYSTTATGGALPSGLTLNSSTGTISGTPtsVQPGTYTFTVTATDSSGLSSSTT 89


                   ....*.
gi 587331497   655 FKYEVT 660
Cdd:pfam05345   90 FTLTVT 95
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 662-929 6.86e-05

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 48.46  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  662 NSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSLSDSVSASKSLSTSESNSVSSSTSTSLV 741
Cdd:NF033849  241 TGYGESVGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTT 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  742 NSQSVSSSMSGSVSKSTSLSDSISNSNSteKSESLSTSTSDSLRTSTSLSDSLSMSTSGSLSKSQSLSTSISGSSSTSAS 821
Cdd:NF033849  321 DSSSHSQSSSYNVSSGTGVSSSHSDGTS--QSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSSGVSGGFSGGIA 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  822 LSDSTSNAISTSTSLSE---SASTSDSISISNSIANSQSASTSKSDSQSTSISLSTSDSKSMSTSESLSDSTSTSGSVSG 898
Cdd:NF033849  399 GGGVTSEGLGASQGGSEgwgSGDSVQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQSVGT 478

                         250       260       270
                  ....*....|....*....|....*....|.
gi 587331497  899 SLSIAASQSVSTSTSDSMSTSEIVSDSISTS 929
Cdd:NF033849  479 SESWSTSQSETDSVGDSTGTSESVSQGDGRS 509
KxYKxGKxW TIGR03715
KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as ...
 16-33 1.00e-03

KxYKxGKxW signal peptide; This model describes a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK and PEP-CTERM forms of signal peptide. This domain tends to occur on long, low-complexity (usually Serine-rich and heavily glycosylated) proteins of the Firmicutes, and (as with YSIRK) the majority of these proteins have the LPXTG cell wall-anchoring motif at the C-terminus.


Pssm-ID: 274741 [Multi-domain]  Cd Length: 23  Bit Score: 38.14  E-value: 1.00e-03
                           10
                   ....*....|....*...
gi 587331497    16 KTRVRLYKSGKNWVKSGI 33
Cdd:TIGR03715    1 KKRYKMYKSGKHWVFAGI 18
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 635-879 2.04e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 43.46  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  635 GQSTVTVVSTDQANNKSTTTFKYEVTRNSMSDSVSTSGSTQQSQSVSTSKADSQSASTSTSGSIVVSTSASTSKSTSVSL 714
Cdd:NF033849  242 GYGESVGHSTSQGQSHSVGTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTTD 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  715 SDSVSASKSLSTSESNSVSSSTSTSLVNSQSVSSSMSGSVSKSTSLSDSISNSNSTEKSESLSTSTSDSLRTSTS----- 789
Cdd:NF033849  322 SSSHSQSSSYNVSSGTGVSSSHSDGTSQSTSISHSESSSESTGTSVGHSTSSSVSSSESSSRSSSSGVSGGFSGGiaggg 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 587331497  790 -LSDSLSMSTSGSLSKS-----QSLSTSISGSSSTSASLSDSTSNAISTSTSLSESASTSDSISISNSIANSQSASTSKS 863
Cdd:NF033849  402 vTSEGLGASQGGSEGWGsgdsvQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQSVGTSES 481

                         250
                  ....*....|....*.
gi 587331497  864 DSQSTSISLSTSDSKS 879
Cdd:NF033849  482 WSTSQSETDSVGDSTG 497
LPXTG_anchor TIGR01167
LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region ...
 2139-2173 3.88e-03

LPXTG-motif cell wall anchor domain; This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other]


Pssm-ID: 273478 [Multi-domain]  Cd Length: 34  Bit Score: 36.68  E-value: 3.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 587331497  2139 RLPDTGDSIKQNGLLGGVMtLLVGLGLMKRKKKKD 2173
Cdd:TIGR01167    1 KLPKTGESGNSLLLLLGLL-LLGLGGLLLRKRKKK 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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