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Conserved domains on  [gi|599760064|gb|EYG86685|]
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large-conductance mechanosensitive channel [Staphylococcus aureus H12890]

Protein Classification

large-conductance mechanosensitive channel protein MscL; MscL family protein( domain architecture ID 10014512)

large-conductance mechanosensitive channel protein MscL opens in response to stretch forces in the membrane lipid bilayer and may participate in the regulation of osmotic pressure changes within the cell| MscL family protein such as large-conductance mechanosensitive channel McsL, which opens in response to stretch forces in the membrane lipid bilayer and may participate in the regulation of osmotic pressure changes within the cell

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mscL PRK13954
large conductance mechanosensitive channel protein MscL;
1-119 2.05e-58

large conductance mechanosensitive channel protein MscL;


:

Pssm-ID: 172460  Cd Length: 119  Bit Score: 175.82  E-value: 2.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFAL 80
Cdd:PRK13954   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 599760064  81 FIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREK 119
Cdd:PRK13954  81 FIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREK 119
 
Name Accession Description Interval E-value
mscL PRK13954
large conductance mechanosensitive channel protein MscL;
1-119 2.05e-58

large conductance mechanosensitive channel protein MscL;


Pssm-ID: 172460  Cd Length: 119  Bit Score: 175.82  E-value: 2.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFAL 80
Cdd:PRK13954   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 599760064  81 FIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREK 119
Cdd:PRK13954  81 FIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREK 119
MscL pfam01741
Large-conductance mechanosensitive channel, MscL;
1-117 1.13e-46

Large-conductance mechanosensitive channel, MscL;


Pssm-ID: 460309  Cd Length: 126  Bit Score: 146.45  E-value: 1.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064    1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDF--------AKEWSFWGIKYGLFIQSVID 72
Cdd:pfam01741   1 MLKEFKEFAMRGNVIDLAVGVIIGAAFGKIVTSLVNDIIMPLIGLLTGGVDFsdkealgaAKGAGAVTINYGAFLNAVIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 599760064   73 FIIIAFALFIFVKIANTLMKKEEAEEEAVVEEN-VVLLTEIRDLLR 117
Cdd:pfam01741  81 FLIIAFVIFLVVKPINKLRKKKEEEPEPPAPPEeEELLTEIRDLLK 126
MscL COG1970
Large-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
1-120 5.08e-45

Large-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441573  Cd Length: 132  Bit Score: 142.54  E-value: 5.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFA----------KEWSFWGIKYGLFIQSV 70
Cdd:COG1970    1 MLKEFKEFAMRGNVIDLAVGVIIGAAFGKIVTSLVNDIIMPLIGLLTGGVDFSnlfivlkgavKEAGAVTINYGAFINAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 599760064  71 IDFIIIAFALFIFVKIANTLMKKEEAEEEAVVE-ENVVLLTEIRDLLREKK 120
Cdd:COG1970   81 INFLIIAFVIFLVVKAINKLKKKEEAAPAAPAPpKEEELLTEIRDLLKAQR 131
mscL TIGR00220
large conductance mechanosensitive channel protein; Protein encodes a channel which opens in ...
 1-119 6.21e-26

large conductance mechanosensitive channel protein; Protein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 272967 [Multi-domain]  Cd Length: 127  Bit Score: 93.78  E-value: 6.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064    1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWG-----IKYGLFIQSVIDFII 75
Cdd:TIGR00220   1 FWKEFKEFAMRGNVVDLAVGVVIGGAFGKIVSSLVADIIMPLLGLLLGGIDFSGLSFTLQdaqavGKYGEFIQNIINFLI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 599760064   76 IAFALFIFVKIANTLMKKEEA---EEEAVVEENVVLLTEIRDLLREK 119
Cdd:TIGR00220  81 IAFAIFMIIKAINKLRRKKKVeeeAAAEAPDAQENLLTEIRDLLKNQ 127
 
Name Accession Description Interval E-value
mscL PRK13954
large conductance mechanosensitive channel protein MscL;
1-119 2.05e-58

large conductance mechanosensitive channel protein MscL;


Pssm-ID: 172460  Cd Length: 119  Bit Score: 175.82  E-value: 2.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFAL 80
Cdd:PRK13954   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWGIKYGLFIQSVIDFIIIAFAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 599760064  81 FIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREK 119
Cdd:PRK13954  81 FIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREK 119
MscL pfam01741
Large-conductance mechanosensitive channel, MscL;
1-117 1.13e-46

Large-conductance mechanosensitive channel, MscL;


Pssm-ID: 460309  Cd Length: 126  Bit Score: 146.45  E-value: 1.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064    1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDF--------AKEWSFWGIKYGLFIQSVID 72
Cdd:pfam01741   1 MLKEFKEFAMRGNVIDLAVGVIIGAAFGKIVTSLVNDIIMPLIGLLTGGVDFsdkealgaAKGAGAVTINYGAFLNAVIN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 599760064   73 FIIIAFALFIFVKIANTLMKKEEAEEEAVVEEN-VVLLTEIRDLLR 117
Cdd:pfam01741  81 FLIIAFVIFLVVKPINKLRKKKEEEPEPPAPPEeEELLTEIRDLLK 126
MscL COG1970
Large-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
1-120 5.08e-45

Large-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441573  Cd Length: 132  Bit Score: 142.54  E-value: 5.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFA----------KEWSFWGIKYGLFIQSV 70
Cdd:COG1970    1 MLKEFKEFAMRGNVIDLAVGVIIGAAFGKIVTSLVNDIIMPLIGLLTGGVDFSnlfivlkgavKEAGAVTINYGAFINAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 599760064  71 IDFIIIAFALFIFVKIANTLMKKEEAEEEAVVE-ENVVLLTEIRDLLREKK 120
Cdd:COG1970   81 INFLIIAFVIFLVVKAINKLKKKEEAAPAAPAPpKEEELLTEIRDLLKAQR 131
mscL PRK00567
large-conductance mechanosensitive channel protein MscL;
1-120 1.00e-41

large-conductance mechanosensitive channel protein MscL;


Pssm-ID: 234795  Cd Length: 134  Bit Score: 134.21  E-value: 1.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDF----------AKEWSFWGIKYGLFIQSV 70
Cdd:PRK00567   1 MLKEFKEFAMRGNVVDLAVGVIIGAAFGKIVSSLVDDIIMPPIGLLIGGVDFsnlaivlgeaQGDAPAVVINYGVFINAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 599760064  71 IDFIIIAFALFIFVKIANTLMKKEEAEEEAVVEEN-VVLLTEIRDLLREKK 120
Cdd:PRK00567  81 IDFLIIAFAIFLLVKLINKLRRKKEEPAAPPAPTTeEVLLTEIRDLLKAQR 131
mscL PRK13952
large conductance mechanosensitive channel protein MscL;
1-120 2.95e-36

large conductance mechanosensitive channel protein MscL;


Pssm-ID: 237569  Cd Length: 142  Bit Score: 120.38  E-value: 2.95e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDF--------------------AKEWSFWG 60
Cdd:PRK13952   3 MLKEFKEFALKGNVMDLAVGVIIGGAFGKIVDSLVNDLIMPIIGLITGGLDFsnyfiqlggapagnpttlaaAKKAGVAV 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064  61 IKYGLFIQSVIDFIIIAFALFIFVKIANTLMKKEEAEEEAVVEENVVLLTEIRDLLREKK 120
Cdd:PRK13952  83 FAYGNFITVLINFLILAFIIFLMVKAINRLRRKEEAAPPPAPPEDVVLLREIRDLLKKKQ 142
mscL PRK13953
large conductance mechanosensitive channel protein MscL;
1-120 4.01e-34

large conductance mechanosensitive channel protein MscL;


Pssm-ID: 184415  Cd Length: 125  Bit Score: 114.51  E-value: 4.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAK-EWSFWG--IKYGLFIQSVIDFIIIA 77
Cdd:PRK13953   1 MLVEFRDFALKGNVLDLAVAVVIGAAFGKIVSSLVNNIIMPLVGVLLGGLDFSDlSWKVGKsvIQYGAFIQSIVDFLIIA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 599760064  78 FALFIFVKIANTLMKKEEAEEEAVVEE-NVVLLTEIRDLLREKK 120
Cdd:PRK13953  81 FAIFIFVKVLTSFIKKKEQQEEETPVPpTEEYLKEIRDLLKQQQ 124
mscL PRK13955
large conductance mechanosensitive channel protein MscL;
1-119 3.75e-33

large conductance mechanosensitive channel protein MscL;


Pssm-ID: 184416  Cd Length: 130  Bit Score: 112.22  E-value: 3.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064   1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWG---IKYGLFIQSVIDFIIIA 77
Cdd:PRK13955   1 MWNEFKKFAFKGNVIDLAVGVVIGAAFGKIVSSLVKDIITPLLGMVLGGVDFTDLKFTFGkssIMYGNFIQTIFDFLIIA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 599760064  78 FALFIFVKIANTLMKKEEAEEEAVV---EENVVLLTEIRDLLREK 119
Cdd:PRK13955  81 ASIFMFVKVFNKLTSKKEEEKEEEIpepTKEEELLGEIRDLLKQQ 125
mscL TIGR00220
large conductance mechanosensitive channel protein; Protein encodes a channel which opens in ...
 1-119 6.21e-26

large conductance mechanosensitive channel protein; Protein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 272967 [Multi-domain]  Cd Length: 127  Bit Score: 93.78  E-value: 6.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599760064    1 MLKEFKEFALKGNVLDLAIAVVMGAAFNKIISSLVENIIMPLIGKIFGSVDFAKEWSFWG-----IKYGLFIQSVIDFII 75
Cdd:TIGR00220   1 FWKEFKEFAMRGNVVDLAVGVVIGGAFGKIVSSLVADIIMPLLGLLLGGIDFSGLSFTLQdaqavGKYGEFIQNIINFLI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 599760064   76 IAFALFIFVKIANTLMKKEEA---EEEAVVEENVVLLTEIRDLLREK 119
Cdd:TIGR00220  81 IAFAIFMIIKAINKLRRKKKVeeeAAAEAPDAQENLLTEIRDLLKNQ 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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