|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
3-916 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1442.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 3 YKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKT 82
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 83 MQGFYAPYVPGWDTHGLPIEQALTKK-GVDR---KKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPE 158
Cdd:COG0060 81 MRGFDVPYVPGWDCHGLPIELKVEKElGIKKkdiEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 159 YEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVV-DADAKFIIWTTTPWTI 237
Cdd:COG0060 161 YEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKDEKALLlLEDAYLVIWTTTPWTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 238 PSNVAITVHPELKYGQYNV-NGEKYIIAEALSDAVAEALDWDKASIklEKEYTGKELEYVVAQHPFL-----DRESLVIN 311
Cdd:COG0060 241 PANLAVAVHPDIDYVLVEVtGGERLILAEALVEAVLKELGIEDYEV--LATFKGAELEGLRYEHPFYyvvgyDRAHPVIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 312 GYHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFIT 391
Cdd:COG0060 319 GDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKIT 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 392 HSYPHDWRTKKPVIFRATPQWFASISKVRHDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAEN- 470
Cdd:COG0060 399 HSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDc 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 471 GEIIMTKETVNHVADLFAEHGSNIWFEREAKD-LLPEGFTHPGSpNGTFTKETDIMDVWFDSGSSHRGVLETRPELSFPA 549
Cdd:COG0060 479 GELHRTEEVIGSVAELLEEEGADAWFELDLHRpFLDETLKCPKC-GGTMRRVPDVLDVWFDSGSMHFAVLENREELHFPA 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 550 DMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLA 629
Cdd:COG0060 558 DFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSDYWG 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 630 DVRISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQ 709
Cdd:COG0060 638 DLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALH 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 710 NFINVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVHLADMPKVVE 789
Cdd:COG0060 718 NFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEESVHLADWPEVDE 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 790 --VDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNasEFLTSF-DALHQLFIVSQVKVVDKLDD 866
Cdd:COG0060 798 elIDEELEAKWDLVREVRSAVLKALEAARKEKLIRQPLEAAVVLYADEELA--AALESLgDLLAEELNVSEVELVDDAED 875
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*...
gi 613185678 867 Q-ATAYEHGD-------IVIEHADGEKCERCWNYSedLGAVDELTHLCPRCQQVVKSL 916
Cdd:COG0060 876 LgKDALKALDvegisvtVEVEKADGEKCERCWHYE--VGWTPEHEGLCRRCVRRVQGL 931
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
16-916 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 1084.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 16 MRGGLPNKEPQIQEKWDAEDQYHKALEKNKGnETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWD 95
Cdd:PLN02843 1 MRANSVTREPEIQKLWEENQVYKRVSDRNNG-ESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 96 THGLPIE----QALTKKgvDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMA 171
Cdd:PLN02843 80 CHGLPIElkvlQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 172 DKGLIYKGKKPVYWSPSSESSLAEAEIEYHD-KRSASIYVAFDVKDDKGVVDA-------DAKFIIWTTTPWTIPSNVAI 243
Cdd:PLN02843 158 LNGYIYRGRKPVHWSPSSRTALAEAELEYPEgHVSKSIYVAFPVVSPSETSPEeleeflpGLSLAIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 244 TVHPELKY-------------------------GQYNVNGEKYIIAEALSDAVAEaldwdKASIKLE--KEYTGKELEYV 296
Cdd:PLN02843 238 AVNDKLQYsvvevqsfsedestsggnkkkrpgnVLKEQQKLFLIVATDLVPALEA-----KWGVKLVvlKTFPGSDLEGC 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 297 VAQHPFLDRES-LVINGYHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGM-FYDKANKAV 374
Cdd:PLN02843 313 RYIHPLYNRESpVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLsVLGEGNAAV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 375 TDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVRHDILDAIENTNFKVNWGKTRIYNMVRDRGEWVIS 454
Cdd:PLN02843 393 VEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCIS 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 455 RQRVWGVPLPVFY-AENGEIIMTKETVNHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSpngTFTKETDIMDVWFDSGS 533
Cdd:PLN02843 473 RQRTWGVPIPVFYhVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAS---DYEKGTDTMDVWFDSGS 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 534 SHRGVLETRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVK-- 611
Cdd:PLN02843 550 SWAGVLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEgg 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 612 --QK-----GADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDtDSIPESELLEVDRYLLNR 684
Cdd:PLN02843 630 knQKqepayGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKPD-NAVPYEDLPSIDKYALFQ 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 685 LREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTA 764
Cdd:PLN02843 709 LENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLA 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 765 EEVWSHTPHVKE----ESVHLADMPKVVE----VDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDK 836
Cdd:PLN02843 789 EDAWQNLPFQEDgsaaESVFEAGWPTPNEewlsFPAEDVDFWSLLLEVRDEVNKVLESARNGKLIGASLEAKVYLHASDA 868
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 837 FNASEFLT------SFDALHQLFIVSQVKVVDKLDDQATAYEH---------GDIVI--EHADGEKCERCWNYSEDLGAV 899
Cdd:PLN02843 869 SLAARLAElcgasnGADELRRIFITSQVEVVSSEDDETAACGSytgeyvegaGRVWVgvSRADGSKCERCWNYSPAVGSF 948
|
970
....*....|....*..
gi 613185678 900 DELTHLCPRCQQVVKSL 916
Cdd:PLN02843 949 SDHPTLCERCYPVVIAQ 965
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
13-831 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 1034.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 13 DFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVP 92
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 93 GWDTHGLPIEQALTKK-GV-DRKKMSTAE---FREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIF 167
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKlGIsGKKEISSLEieeFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 168 GEMADKGLIYKGKKPVYWSPSSESSLAEAEIE----YHDKRSASIYVAFDVKDDK--GVVDADAKFIIWTTTPWTIPSNV 241
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEykenYKDVKDPSIYVKFPVKKDKktYLKVKLSSLLIWTTTPWTLPSNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 242 AITVHPELKYG--QYNVNGEKYIIAEALSDAVAEALDWDKASIKlekEYTGKELEYVVAQHPFLDRESL-------VING 312
Cdd:TIGR00392 241 AIAVHPDFEYAlvQDNTKVEYFILAKKLVEKLYNKAGSDYEIIK---TFKGSDLEGLEYEHPLYDFVSQlkegapvVIGG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 313 YHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEG-------MFYDKANKAVTDLLTEKGALL 385
Cdd:TIGR00392 318 DHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGrfvkdadKDIIKANKIIIEQLKDKGLLL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 386 KLDFITHSYPHDWRTKKPVIFRATPQWFASISKVRHDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPV 465
Cdd:TIGR00392 398 KAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCISRQRYWGIPIPI 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 466 FYAENGEIIMTKETVNHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSPnGTFTKETDIMDVWFDSGSSHRGVLETRPE- 544
Cdd:TIGR00392 478 WYCEDTGEPIVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYPFEn 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 545 ----LSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARL 620
Cdd:TIGR00392 557 ekfkEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRL 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 621 WVSSTDYLADVRISDEILKQTSDVYRKIR-NTLRFML--GNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYE 697
Cdd:TIGR00392 637 YVASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEALE 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 698 NFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEqRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTP-HVKE 776
Cdd:TIGR00392 717 KYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCE-AKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPgGEEE 795
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613185678 777 ESVHLADMPKV--------VEVDQALLDK-WRTFMNLRDDVNRALETARNEKVIGKSLEAKVTI 831
Cdd:TIGR00392 796 ESVHLNLWPEVdeefideaLEANMAIVREiVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKA 859
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
26-634 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 882.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 26 QIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQAL 105
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 106 TKK-----GVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGK 180
Cdd:pfam00133 81 EKKlgikeKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 181 KPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKgvvdaDAKFIIWTTTPWTIPSNVAITVHPELKYGqynVNGEK 260
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDE-----GASLVIWTTTPWTLPGNTAVAVNPEFDYV---ITGEG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 261 YIIAEALSDAVAEALDWDKasikLEKEYTGKELEYVVAQHPFLDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIVGQK 340
Cdd:pfam00133 233 YILAEALLKSLYKKGTDKK----ILEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 341 YELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVR 420
Cdd:pfam00133 309 HNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELA 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 421 HDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAEN-GEIIMTKETVNHVADLFAEHGSNIWFERE 499
Cdd:pfam00133 389 DQALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCRGELFELVAGRFEEEGSIKWLHRE 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 500 AKDLLpegfthpGSPNGTFTKETDIMDVWFDSGSSHRGVL----ETRPELS--FPADMYLEGSDQYRGWFNSSITTSVAT 573
Cdd:pfam00133 469 AKDKL-------GYGKGTLEQDEDVLDTWFSSGSWPFSTLgwpfVNTEEFKkfFPADMLLEGSDQTRGWFYRMIMLSTAL 541
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 613185678 574 RGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRIS 634
Cdd:pfam00133 542 TGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
9-841 |
1.08e-140 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 438.47 E-value: 1.08e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 9 MPKTDFPMRGGLPNKEPQIQEKWDAEDQYhkALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGfYA 88
Cdd:PRK13208 1 KMMPELPKKYDPEELEEKWQKIWEEEGTY--KFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRG-YN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 89 PYVP-GWDTHGLPIE-QALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRI 166
Cdd:PRK13208 78 VFFPqGWDDNGLPTErKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 167 FGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVVdadakfiIWTTTPWTIPSNVAITVH 246
Cdd:PRK13208 158 FLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEEIE-------IATTRPELLPACVAVVVH 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 247 PElkygqynvnGEKYiiaealsdavaealdwdkasikleKEYTGKELeyVVaqhPFLDRESLVINGYHVTTDAGTG---- 322
Cdd:PRK13208 231 PD---------DERY------------------------KHLVGKTA--IV---PLFGVEVPILADPLVDPDFGTGavmi 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 323 CVHtapGHGEDDYIVgQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKK 402
Cdd:PRK13208 273 CTF---GDKTDVTWW-RELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDT 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 403 PVIFRATPQWFASISKVRHDILDAIENTNFKVNWGKTRIYNMVRD-RGEWVISRQRVWGVPLPVFYAEN-GEIIMTKEtv 480
Cdd:PRK13208 349 PLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRVRLENWIEGlNWDWCISRQRYFGTPIPVWYCKDcGHPILPDE-- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 481 nhvADLFAehgsniwfeREAKDLlPEGFTHPGSPNGTFTKETDIMDVWFDSG-----SSHRGVLETRPELSFPADMYLEG 555
Cdd:PRK13208 427 ---EDLPV---------DPTKDE-PPGYKCPQCGSPGFEGETDVMDTWATSSitpliVTGWERDEDLFEKVFPMDLRPQG 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 556 SDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISD 635
Cdd:PRK13208 494 HDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSDTPFDE 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 636 EILKQTSDVYRKIRNTLRFMLGnindFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVE 715
Cdd:PRK13208 574 KQVKIGRRLLTKLWNASRFVLH----FSADPEPDKAEVLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHV 649
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 716 LSNFYLDYGKDILYIEqRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWShtpHVKEESVHLADMPKVVE--VDQA 793
Cdd:PRK13208 650 FCDDYLELVKSRAYGE-DEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWS---WLYGGSVHRASWPEPDEelIDEE 725
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|.
gi 613185678 794 LLDKWRTFMNlrddVNRALETARNEKviGKSLEA---KVTIASNDKFNASE 841
Cdd:PRK13208 726 DEELGELAKE----ILSAVRKYKSEA--GLSLNAplkKVEVYGPADLELLE 770
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
24-861 |
1.29e-134 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 424.09 E-value: 1.29e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 24 EPQIQEKWDAEDQYHKALEKNKgnETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLP--- 100
Cdd:TIGR00422 11 EKKWYKKWEKSGFFKPDGNSNK--PPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAtqv 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 101 -IEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKG 179
Cdd:TIGR00422 89 kVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 180 KKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDkgvvdADAKFIIWTTTPWTIPSNVAITVHPElkygqynvnGE 259
Cdd:TIGR00422 169 EYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANG-----SKDYLVVATTRPETMFGDTAVAVHPE---------DE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 260 KYiiaealsdavaealdwdkasikleKEYTGKEleyvvAQHPFLDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIVGQ 339
Cdd:TIGR00422 235 RY------------------------KHLIGKK-----VILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGK 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 340 KYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKV 419
Cdd:TIGR00422 286 RHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKL 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 420 RHDILDAIENTNFKV---NWGKtRIYNMVRDRGEWVISRQRVWGVPLPVFYAEN-GEIimtketvnHVADLfaehgsniw 495
Cdd:TIGR00422 366 ADKALEAAEEGEIKFvpkRMEK-RYLNWLRNIKDWCISRQLIWGHRIPVWYCKEcGEV--------YVAKE--------- 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 496 fereakDLLPEGFTHPGsPNGTFTKETDIMDVWFDSG---SSHRGVLETRPELS--FPADMYLEGSDQYRGWFNSSITTS 570
Cdd:TIGR00422 428 ------EPLPDDKTNTG-PSVELEQDTDVLDTWFSSSlwpFSTLGWPDETKDLKkfYPTDLLVTGYDIIFFWVARMIFRS 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 571 VATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSS-TDYLADVRISDEILKQTSDVYRKIR 649
Cdd:TIGR00422 501 LALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASlVTPGDDINFDWKRVESARNFLNKLW 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 650 NTLRFMLGNINDFnpDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILY 729
Cdd:TIGR00422 581 NASRFVLMNLSDD--LELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLY 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 730 IEqrDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHvKEESVHLADMPKVVE--VDQALLdkwrTFMNLRDD 807
Cdd:TIGR00422 659 NG--NEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKE-GADSIMLQSYPVVDAefVDEEAE----KAFELLKE 731
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....
gi 613185678 808 VNRALETARNEKVIGKSLEAKVTIASNDKFNASEFLTSFDALHQLFIVSQVKVV 861
Cdd:TIGR00422 732 IIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVV 785
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
21-817 |
7.73e-119 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 389.85 E-value: 7.73e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 21 PNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLP 100
Cdd:PLN02882 11 PKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 101 IEQALTKK-GVDRK----KMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGL 175
Cdd:PLN02882 91 VEYEIDKKlGIKRRddvlKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 176 IYKGKKPVYWSPSSESSLA--EAEIEYHDKRSASIYVAFDVKDDkgvvDADAKFIIWTTTPWTIPSNVAITVHPELKYGQ 253
Cdd:PLN02882 171 VYKGFKVMPYSTACKTPLSnfEAGLNYKDVSDPAVMVSFPIVGD----PDNASFVAWTTTPWTLPSNLALCVNPNFTYVK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 254 Y--NVNGEKYIIAEALSDAVAEALDWDKASIK---------LEKEYTGKEL---EYVVAQHPFLDRES----LVINGYhV 315
Cdd:PLN02882 247 VrnKYTGKVYIVAESRLSALPTAKPKSKKGSKpenaaegyeVLAKVPGSSLvgkKYEPLFDYFSEFSDtafrVVADDY-V 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 316 TTDAGTGCVHTAPGHGEDDY-------IVGQKYELPVisPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLD 388
Cdd:PLN02882 326 TDDSGTGVVHCAPAFGEDDYrvclangIIEKGGNLPV--PVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 389 FITHSYPHDWRTKKPVIFRATPQWFASISKVRHDILdaiENtNFKVNW-----GKTRIYNMVRDRGEWVISRQRVWGVPL 463
Cdd:PLN02882 404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLL---EN-NKQTYWvpdyvKEKRFHNWLENARDWAVSRSRFWGTPL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 464 PVFYAENGEIIMTKETVNHVADLFAEHGSNIwfEREAKDLLpegfTHPGSPNGTFT---KETDIMDVWFDSGSSHRGVL- 539
Cdd:PLN02882 480 PIWISDDGEEVVVIGSIAELEKLSGVKVTDL--HRHFIDHI----TIPSSRGPEFGvlrRVDDVFDCWFESGSMPYAYIh 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 540 -----ETRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKG 614
Cdd:PLN02882 554 ypfenKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 615 ADIARLW-VSSTDYLAD-VRISDE-ILKQTSDVYRKIRNTLRFMLGNI--------NDFNPDTDSIPESELLEVDRYLL- 682
Cdd:PLN02882 634 ADALRLYlINSPVVRAEpLRFKEEgVFGVVKDVFLPWYNAYRFLVQNAkrleveggAPFVPLDLAKLQNSANVLDRWINs 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 683 --NRLREFTASTINNYEnfdylnIYQEVQ---NFINvELSNFYLDYGKDILYIEQRDSHIRRSMQTvLYQILVDMTKLLA 757
Cdd:PLN02882 714 atQSLVKFVREEMGAYR------LYTVVPylvKFID-NLTNIYVRFNRKRLKGRTGEEDCRTALST-LYNVLLTSCKVMA 785
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613185678 758 PILVHTAEEVWSHTPHV---KEESVHLADMPkvvEVDQALLDKwrtfmNLRDDVNR---ALETARN 817
Cdd:PLN02882 786 PFTPFFTEVLYQNLRKVlpgSEESIHYCSFP---QVDEGELDE-----RIEQSVSRmqtVIELARN 843
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
48-633 |
1.61e-114 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 353.85 E-value: 1.61e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 48 ETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKK-----GVDRKKMSTAEFRE 122
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKElgisgKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 123 KCKEFALEqielqkkdfrrlgvrgdfndpyitlkpeYEAAQIRIFGEMAdkgliykgkkpvYWspssesslaeaeieyhd 202
Cdd:cd00818 81 KCREFALR----------------------------YVDEQEEQFQRLG------------VW----------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 203 krsasiyvafdvkddkgvvdadakfiiwtttpwtipsnvaitvhpelkygqynvngekyiiaealsdavaeaLDWDKASI 282
Cdd:cd00818 104 ------------------------------------------------------------------------VDWENPYK 111
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 283 KLEKEYTGKELEyvvaqhpfldreslvingyhvttdagtgcvhtapghgeddyivgqkyelpvispiddkgVFTEeggqf 362
Cdd:cd00818 112 TMDPEYMESVWW-----------------------------------------------------------VFKQ----- 127
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 363 egmfydkankavtdlLTEKGaLLKLDFithsYPHDWrtkkPVIFRATPQWFASISKVRHDILDAIENTNFKVNWGKTRIY 442
Cdd:cd00818 128 ---------------LHEKG-LLYRGY----KVVPW----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFG 183
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 443 NMVRDRGEWVISRQRVWGVPLPVFYAE-NGEIIMtketvnhvadlfaehgsniwfereakdllpegfthpgspngtfTKE 521
Cdd:cd00818 184 NWLENRRDWCISRQRYWGTPIPVWYCEdCGEVLV-------------------------------------------RRV 220
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 522 TDIMDVWFDSGSSHRGVLETRPE-----LSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKM 596
Cdd:cd00818 221 PDVLDVWFDSGSMPYAQLHYPFEnedfeELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKM 300
|
570 580 590
....*....|....*....|....*....|....*...
gi 613185678 597 SKSLGNVIVPDQVVKQKGADIARLWVSSTD-YLADVRI 633
Cdd:cd00818 301 SKSLGNYVDPQEVVDKYGADALRLWVASSDvYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
21-780 |
3.80e-96 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 328.46 E-value: 3.80e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 21 PN---KEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTH 97
Cdd:PTZ00427 72 PNiveEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCH 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 98 GLPIEQALTK-----KGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMAD 172
Cdd:PTZ00427 152 GLPIEYEIEKenninKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 173 KGLIYKGKKPVYWSPSSESSLA--EAEIEYHDKRSASIYVAF-------DVKDDKGVVDA-------------------- 223
Cdd:PTZ00427 232 NNYVYKSFKVMPYSCKCNTPISnfELNLNYKDTPDPSIIISFvlcsdfpKVEEECNIEEDkqllgekysvlynnkrensn 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 224 --------------DAKFIIWTTTPWTIPSNVAITVHPELKYGQ-YNVNGEK-YIIAEALSDAVAEALDWDKASIKLEKE 287
Cdd:PTZ00427 312 ngnnnstnnvcyaqHSEILAWTTTPWTLPSNLALCVNEHFTYLRiHHVKSNRvVIVGECRLEWIMKELKWNVEDLKIVNR 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 288 YTGKELE---------YVVAQHPFLDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIVGQKYEL--P----VISPIDDK 352
Cdd:PTZ00427 392 FKGKELKglrykplftNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPekniFIDPLDAN 471
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 353 GVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVRHDILDAIENTNF 432
Cdd:PTZ00427 472 GYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYW 551
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 433 -KVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETVNH---------VADLFAEHGSNIWFEReakd 502
Cdd:PTZ00427 552 iPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHleelsgvknINDLHRHFIDHIEIKN---- 627
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 503 llPEGFTHPgspngTFTKETDIMDVWFDSGSS-----HRGVLETRPELS--FPADMYLEGSDQYRGWFNSSITTSVATRG 575
Cdd:PTZ00427 628 --PKGKTYP-----KLKRIPEVFDCWFESGSMpyakvHYPFSTEKEDFHkiFPADFIAEGLDQTRGWFYTLLVISTLLFD 700
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 576 VSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVsstdyLADVRISDEILK-QTSDV---------- 644
Cdd:PTZ00427 701 KAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYL-----INSVAVRAENLKfQEKGVnevvksfilp 775
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 645 -YRKIR----NTLRFMLGNINDFNPDTDSIPESELLeVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINvELSNF 719
Cdd:PTZ00427 776 fYHSFRffsqEVTRYECLNKKQFLFNTDYIYKNDNI-MDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIE-NLTNW 853
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 613185678 720 YLDYGKDILYIEQRDSHIRRSMQTvLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVH 780
Cdd:PTZ00427 854 YIRLNRDRMRGSLGEENCLQSLCT-TYRTLHLFTVLMAPFTPFITEYIYQQLRRVKSTNEH 913
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
24-866 |
6.24e-92 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 310.50 E-value: 6.24e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 24 EPQIQEKWDAEDqYHKALEKNKGNETFILhdGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGlpI-- 101
Cdd:PRK05729 15 EAKWYQKWEEKG-YFKPDDNSKKPFSIVI--PPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHAG--Iat 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 102 ----EQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIY 177
Cdd:PRK05729 90 qmvvERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 178 KGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVVdadakfIIWTTTPWTIPSNVAITVHPElkygqynvn 257
Cdd:PRK05729 170 RGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYL------VVATTRPETMLGDTAVAVNPE--------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 258 GEKYiiaealsdavaealdwdkasikleKEYTGKELEyvvaqHPFLDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIV 337
Cdd:PRK05729 235 DERY------------------------KHLIGKTVI-----LPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEV 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 338 GQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASIS 417
Cdd:PRK05729 286 GKRHNLPMINIMDEDGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMK 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 418 KVRHDILDAIEN--TNFkV--NWGKTriYN--M--VRDrgeWVISRQRVWGVPLPVFYAENGEIIMTKEtvnhvadlfae 489
Cdd:PRK05729 366 PLAKPALEAVENgeIKF-VpeRWEKT--YFhwMenIQD---WCISRQLWWGHRIPAWYDEDGEVYVGRE----------- 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 490 hgsniwferEAKDLlpegfthpgsPNGTFTKETDIMDVWFDSGsshrgvL---------ETRPELS--FP---------- 548
Cdd:PRK05729 429 ---------EPEAR----------EKALLTQDEDVLDTWFSSA------LwpfstlgwpEKTEDLKrfYPtsvlvtgfdi 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 549 -----ADMYLEGsdqyrGWFnssittsvatRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVS 623
Cdd:PRK05729 484 iffwvARMIMMG-----LHF----------TGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLA 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 624 StdyLA----DVRISDEILKQtsdvYR----KIRNTLRFMLGNINDfNPDTDSIPESELLEVDRYLLNRLREFTASTINN 695
Cdd:PRK05729 549 A---LAspgrDIRFDEERVEG----YRnfanKLWNASRFVLMNLEG-ADVGELPDPEELSLADRWILSRLNRTVAEVTEA 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 696 YENFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDShIRRSMQTVLYQILvdmtKLLAPILVHTAEEVWSHTPHV- 774
Cdd:PRK05729 621 LDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAAKRA-TRATLAYVLEQIL----RLLHPFMPFITEELWQKLAPLg 695
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 775 KEESVHLADMPKVVEVDQALLDKWrtfMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNASEFLTSFDALHQLFI 854
Cdd:PRK05729 696 IEESIMLAPWPEADEAIDEAAEAE---FEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLAR 772
|
890
....*....|..
gi 613185678 855 VSQVKVVDKLDD 866
Cdd:PRK05729 773 LESLEILADDEE 784
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
633-809 |
1.03e-89 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 282.49 E-value: 1.03e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 633 ISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFI 712
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 713 NVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHV-KEESVHLADMPKVVEV- 790
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEkKEESVFLEDWPELPEEw 160
|
170 180
....*....|....*....|
gi 613185678 791 -DQALLDKWRTFMNLRDDVN 809
Cdd:cd07960 161 kDEELEEKWEKLLALRDEVN 180
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
49-633 |
1.67e-82 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 268.52 E-value: 1.67e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 49 TFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMstaEFREKCKEFA 128
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKT---IWIEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 129 LEQIElqkkdfrrlgvrgdfndpyitlkpEYEAAQIRIFGEMAdkgliykgkkpvYWspssesslaeaeieyhdkrsasi 208
Cdd:cd00668 78 KEFVE------------------------EMSGEHKEDFRRLG------------IS----------------------- 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 209 yvafdvkddkgvvdadakfiiwtttpwtipsnvaitvhpelkygqynvngekyiiaealsdavaeaLDWDKASIKLEKEY 288
Cdd:cd00668 99 ------------------------------------------------------------------YDWSDEYITTEPEY 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 289 tgkeleyvvaqhpfldrESLVIngyhvttdagtgcvhtapghgeddYIVGQKYElpvispiddkgvfteeggqfEGMFYd 368
Cdd:cd00668 113 -----------------SKAVE------------------------LIFSRLYE--------------------KGLIY- 130
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 369 kankavtdlltekgallkldfithsyphdwRTKKPVifRATPQWFASISKVRHDILDAIENTNFKVNWGKTRIYNMVRDR 448
Cdd:cd00668 131 ------------------------------RGTHPV--RITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESL 178
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 449 GEWVISRQRVWGVPLPvfyaengeiimtketvnhvadlfaehgsniwfereakdllpegfthpgspngtftkeTDIMDVW 528
Cdd:cd00668 179 LDWAISRQRYWGTPLP---------------------------------------------------------EDVFDVW 201
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 529 FDSGSSHRGVLETRPE-----LSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNV 603
Cdd:cd00668 202 FDSGIGPLGSLGYPEEkewfkDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNV 281
|
570 580 590
....*....|....*....|....*....|.
gi 613185678 604 IVPDQVVKQKGADIARLWVSSTD-YLADVRI 633
Cdd:cd00668 282 IDPSDVVEKYGADALRYYLTSLApYGDDIRL 312
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
24-862 |
5.52e-82 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 283.10 E-value: 5.52e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 24 EPQIQEKWDaEDQYHKAlEKNKGNETF---IlhdGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDtH-Gl 99
Cdd:COG0525 13 EAKWYQYWE-ENGYFKA-DPDSDKEPFtivI---PPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaG- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 100 pI------EQALTKKGVDRKKMSTAEFREKCKEFA-------LEQIelqkkdfRRLGVRGDFNDPYITLKPEYEAAQIRI 166
Cdd:COG0525 86 -IatqavvERQLAEEGKSRHDLGREKFLERVWEWKeesggtiTNQL-------RRLGASCDWSRERFTMDEGLSKAVREV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 167 FGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVVdadakfIIWTTTPWTIPSNVAITVH 246
Cdd:COG0525 158 FVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYI------VVATTRPETMLGDTAVAVH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 247 PElkygqynvnGEKYiiaealsdavaealdwdkasikleKEYTGKELEyvvaqHPFLDRESLVINGYHVTTDAGTGCVHT 326
Cdd:COG0525 232 PE---------DERY------------------------KHLIGKTVI-----LPLVGREIPIIADEYVDPEFGTGAVKI 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 327 APGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIF 406
Cdd:COG0525 274 TPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEP 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 407 RATPQWFASISKVRHDILDAIEN--TNFkV--NWGKTriYN--M--VRDrgeWVISRQRVWGVPLPVFYAENGEIImtke 478
Cdd:COG0525 354 YLSDQWFVKMKPLAKPAIEAVEDgeIKF-VpeRWEKT--YFhwMenIRD---WCISRQLWWGHRIPAWYCPDGEVY---- 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 479 tvnhVAdlfaehgsniwfeREAKDLLPEgfthpgSPNGTFTKETDIMDVWFDSG---------------------SShrg 537
Cdd:COG0525 424 ----VA-------------RTEPEACAK------AGSVNLTQDEDVLDTWFSSAlwpfstlgwpektedlkyfypTS--- 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 538 VLETRPELSFP--ADMylegsdqyrgwfnssITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGA 615
Cdd:COG0525 478 VLVTGFDIIFFwvARM---------------IMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGA 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 616 DIARLwvssTdyLA-------DVRISDEILKQtsdvYR----KIRNTLRFMLGNINDFNPDTDsIPESELLEVDRYLLNR 684
Cdd:COG0525 543 DALRF----T--LAalaspgrDIKFDEERVEG----YRnfanKLWNASRFVLMNLEGFDPGLD-PDPEELSLADRWILSR 611
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 685 LREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILY--IEQRDSHIRRSMQTVLYQILvdmtKLLAPILVH 762
Cdd:COG0525 612 LNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLYggDEAAKRETRATLVYVLEQIL----RLLHPFMPF 687
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 763 TAEEVWSHTPHVKE-ESVHLADMPKVVE--VDQALLDKWRTFMnlrdDVNRALETARNEKVIGKSLEAKVTIASNDKFNA 839
Cdd:COG0525 688 ITEEIWQKLPPRKEgESIMLAPWPEADEelIDEEAEAEFEWLK----EVISAIRNIRAEMNIPPSKKLPLLLKGADEADR 763
|
890 900
....*....|....*....|...
gi 613185678 840 SEFLTSFDALHQLFIVSQVKVVD 862
Cdd:COG0525 764 ARLEENAAYIKRLARLEEITILV 786
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
26-862 |
1.79e-79 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 279.18 E-value: 1.79e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 26 QIQEKWDA---EDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLP-- 100
Cdd:PRK14900 23 EVEARWYPfwqERGYFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAtq 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 101 --IEQALTK-KGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIY 177
Cdd:PRK14900 103 miVEKELKKtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 178 KGKKPVYWSPSSESSLAEAEIEYHDKRSASIY-VAFDVKDdkgvvdADAKFIIWTTTPWTIPSNVAITVHPElkygqynv 256
Cdd:PRK14900 183 REKKLINWCPDCRTALSDLEVEHEEAHQGELWsFAYPLAD------GSGEIVVATTRPETMLGDTAVAVHPL-------- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 257 nGEKYiiaealsdavaealdwdkasikleKEYTGKELeyvvaQHPFLDRE-SLVINGYHVTTDAGTGCVHTAPGHGEDDY 335
Cdd:PRK14900 249 -DPRY------------------------MALHGKKV-----RHPITGRTfPIVADAILVDPKFGTGAVKVTPAHDFNDF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 336 IVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKldfithSYPHDW------RTKKPVIFRAT 409
Cdd:PRK14900 299 EVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRG------AKPHVLplgrcqRSATILEPLLS 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 410 PQWFASISKVRHDILDAIENTNFKV---NWGKTRIYNMvRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETvnhvadl 486
Cdd:PRK14900 373 DQWYVRIEPLARPAIEAVEQGRTRFipeQWTNTYMAWM-RNIHDWCISRQLWWGHQIPAWYCPDGHVTVARET------- 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 487 faehgsniwfereakdllPEGFTHPGSpnGTFTKETDIMDVWFDSG---SSHRGVLETRPELS--FPADMYLEGSDQYRG 561
Cdd:PRK14900 445 ------------------PEACSTCGK--AELRQDEDVLDTWFSSGlwpFSTMGWPEQTDTLRtfYPTSVMETGHDIIFF 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 562 WFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSS-TDYLADVRISDEILKQ 640
Cdd:PRK14900 505 WVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAAlTAQGRDIKLAKERIEG 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 641 TSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFY 720
Cdd:PRK14900 585 YRAFANKLWNASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWY 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 721 LDYGKDILYIEqrDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTP-----HVKEESVHLADMPKVVEVDQALL 795
Cdd:PRK14900 665 IELAKEALASE--DPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvgaSAWADSVLAAEYPRKGEADEAAE 742
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613185678 796 DKWRTFMNLRDdvnrALETARNEKVIGKSL----EAKVTIASNDKfNASEFLTSFDA--LHQLFIVSQVKVVD 862
Cdd:PRK14900 743 AAFRPVLGIID----AVRNIRGEMGIPWKVklgaQAPVEIAVADP-ALRDLLQAGELarVHRVAGVEGSRLVV 810
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
24-776 |
2.68e-68 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 246.01 E-value: 2.68e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 24 EPQIQEKWDAEDQYHKALEKnkGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHG----L 99
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDR--GGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 100 PIEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKG 179
Cdd:PLN02943 144 VVEKMLASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 180 KKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDkgvvdADAKFIIWTTTPWTIPSNVAITVHPElkygqynvnGE 259
Cdd:PLN02943 224 SYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGG-----SEDFLTIATTRPETLFGDVAIAVNPE---------DD 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 260 KYiiaealsdavaealdwdkasikleKEYTGKeleyvVAQHPF-LDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIVG 338
Cdd:PLN02943 290 RY------------------------SKYIGK-----MAIVPMtYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 339 QKYELPVISPIDDKGVFTEEGGqfegMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISK 418
Cdd:PLN02943 341 RKLGLPILNVMNKDGTLNEVAG----LYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEP 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 419 VRHDILDAIENTNFKVNWGK-TRIYNM-VRDRGEWVISRQRVWGVPLPVFYAENG----EIIMTKETVNHVADLFAEHGS 492
Cdd:PLN02943 417 LAEKALKAVENGELTIIPERfEKIYNHwLSNIKDWCISRQLWWGHRIPVWYIVGKdceeDYIVARSAEEALEKAREKYGK 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 493 NIwfereakdllpegfthpgspngTFTKETDIMDVWFDSGSSHRGVLeTRPELS-------FPADMYLEGSDQYRGWFNS 565
Cdd:PLN02943 497 DV----------------------EIYQDPDVLDTWFSSALWPFSTL-GWPDVSaedfkkfYPTTVLETGHDILFFWVAR 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 566 SITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVY 645
Cdd:PLN02943 554 MVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLTSNKAFT 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 646 RKIRNTLRFMLGNIndfnPDTDSIP------------ESELLEV---DRYLLNRLREFTASTINNYENFDYLNIYQEVQN 710
Cdd:PLN02943 634 NKLWNAGKFVLQNL----PSQSDTSawehilackfdkEESLLSLplpECWVVSKLHELIDSVTTSYDKYFFGDVGREIYD 709
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613185678 711 FINVELSNFYLDYGKDILYIEQRDSHIRRSmQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKE 776
Cdd:PLN02943 710 FFWSDFADWYIEASKTRLYHSGDNSALSRA-QAVLLYVFENILKLLHPFMPFVTEELWQALPYRKE 774
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
31-864 |
3.37e-67 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 242.99 E-value: 3.37e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 31 WDAEDQYH--KALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLP----IEQA 104
Cdd:PTZ00419 41 WEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAtqvvVEKK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 105 LTKK-GVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPV 183
Cdd:PTZ00419 121 LMKEeNKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 184 YWSPSSESSLAEAEIEYHD-KRSASIYV-AFDVKDDKGV---------VDADAKFIIWTTTPWTIPSNVAITVHPelkyg 252
Cdd:PTZ00419 201 NWCCYLKTAISDIEVEFEEiEKPTKITIpGYDKKVEVGVlwhfaypleDSGQEEIVVATTRIETMLGDVAVAVHP----- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 253 qynvNGEKYiiaealsdavaealdwdkasikleKEYTGKELeyvvaQHPFL-DRESLVI-NGYHVTTDAGTGCVHTAPGH 330
Cdd:PTZ00419 276 ----KDERY------------------------KKLHGKEL-----IHPFIpDRKIPIIaDDELVDMEFGTGAVKITPAH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 331 GEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGaLLKlDFITHSY--PHDWRTKKPVIFRA 408
Cdd:PTZ00419 323 DPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMG-LLR-DKVPNPMrlPRCSRSGDIVEPML 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 409 TPQWFASISKVRHDILDAIENtnfkvnwGKTRIYNM------------VRDrgeWVISRQRVWGVPLPVFyaengEIIMT 476
Cdd:PTZ00419 401 IPQWYVNCKDMAKRAVEAVRN-------GELKIIPSshenvwyhwlenIQD---WCISRQLWWGHRIPAY-----RVISK 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 477 KETVNhvadlfaEHGSNIWF----EREAKD-------LLPEGFthpgspngTFTKETDIMDVWFDSG---SSHRGVLETR 542
Cdd:PTZ00419 466 GPETD-------PSDEEPWVvarsEEEALEkakkkfgLSEEDF--------ELEQDEDVLDTWFSSGlfpFSTLGWPDQT 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 543 PELS--FPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVK--------- 611
Cdd:PTZ00419 531 DDLQrfFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEgislqdlnq 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 612 ------------------QK----------GADIARLWVSStdyladvrisdeILKQTSDV---------YR----KIRN 650
Cdd:PTZ00419 611 klyegnlpekeikraielQKkefpngipecGTDALRFGLLA------------YTQQGRNInldinrvvgYRhfcnKLWN 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 651 TLRFMLGNINDFNPD-----TDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGK 725
Cdd:PTZ00419 679 AVKFALMKLLKDFNLpnstlFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIK 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 726 DILYIEQrDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHV--KEESVHLADMPKVVEV--DQALLDKWRTF 801
Cdd:PTZ00419 759 PRLSKQS-DGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYlrKSESISIAKYPQPNPGwnNEALDEEMKII 837
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613185678 802 MNLRDDVnraletarnekvigKSLEAKVTIASNDKFNAseFLTSFDALHQLFIVSQVKVVDKL 864
Cdd:PTZ00419 838 MSIVKSI--------------RSLIATLGIPNKTKPDC--YVTAKDAELIELIESAENLISTL 884
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
56-624 |
1.71e-56 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 199.78 E-value: 1.71e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 56 PPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLP----IEQALTKKGVDRKKMSTAEFREKCKEFALEQ 131
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIAtqvvVEKKLGIEGKTRHDLGREEFLEKCWEWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 132 IELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHdkrsasiyva 211
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEVCSR---------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 212 fdvkddkgvvdadakfiiwtttpwtipsnvaitvhpelkygqynvngekyiiaealSDAVAEaldwdkasiklekeytgk 291
Cdd:cd00817 159 --------------------------------------------------------SGDVIE------------------ 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 292 eleyvvaqhpfldreslvingyhvttdagtgcvhtapghgeddyivgqkyelPVISPiddkgvfteeggqfegmfydkan 371
Cdd:cd00817 165 ----------------------------------------------------PLLKP----------------------- 169
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 372 kavtdlltekgallkldfithsyphdwrtkkpvifratpQWFASISKVRHDILDAIENTNFKV---NWGKtRIYNMVRDR 448
Cdd:cd00817 170 ---------------------------------------QWFVKVKDLAKKALEAVKEGDIKFvpeRMEK-RYENWLENI 209
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 449 GEWVISRQRVWGVPLPVFYAENGEIIMTKETvnhvadlfaehgsniwfEREAKDLLPEGFTHPGSPNgTFTKETDIMDVW 528
Cdd:cd00817 210 RDWCISRQLWWGHRIPAWYCKDGGHWVVARE-----------------EDEAIDKAAPEACVPCGGE-ELKQDEDVLDTW 271
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 529 FDSG---SSHRGVLETRPELS--FPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNV 603
Cdd:cd00817 272 FSSSlwpFSTLGWPEETKDLKkfYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNV 351
|
570 580
....*....|....*....|.
gi 613185678 604 IVPDQVVKQKGADIARLWVSS 624
Cdd:cd00817 352 IDPLDVIDGYGADALRFTLAS 372
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
31-789 |
3.50e-43 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 170.46 E-value: 3.50e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 31 WDAEDqYHKAlEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGV 110
Cdd:PLN02381 113 WEKSG-YFGA-DAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLM 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 111 DRKKMSTAEF-REkckEFALEQIELQK-------KDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKP 182
Cdd:PLN02381 191 RERHLTRHDIgRE---EFVSEVWKWKDeyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRL 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 183 VYWSPSSESSLAEAEIEYHDKRSASIYV--AFDVKDDKGVVDADA--------KFIIWTTTPWTIPSNVAITVHPElkyg 252
Cdd:PLN02381 268 VNWDCTLRTAISDVEVDYIDIKERTLLKvpGYDKPVEFGVLTSFAyplegglgEIVVATTRIETMLGDTAIAIHPD---- 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 253 qynvnGEKYiiaealsdavaealdwdkasiklekeytgKELEYVVAQHPFLDRESLVI-NGYHVTTDAGTGCVHTAPGHG 331
Cdd:PLN02381 344 -----DERY-----------------------------KHLHGKFAVHPFNGRKLPIIcDAILVDPNFGTGAVKITPAHD 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 332 EDDYIVGQKYELPVISPIDDKGVFTEEGG-QFEGMFYDKANKAVTDLLTEKGAL-------LKLDFIThsyphdwRTKKP 403
Cdd:PLN02381 390 PNDFEVGKRHNLEFINIFTDDGKINSNGGsEFAGMPRFAAREAVIEALQKKGLYrgaknneMRLGLCS-------RTNDV 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 404 VIFRATPQWFASISKVRHDILDAIENT----------NFKVNWgkTRIYNMVRDrgeWVISRQRVWGVPLPVFYAengei 473
Cdd:PLN02381 463 VEPMIKPQWFVNCSSMAKQALDAAIDGenkklefipkQYLAEW--KRWLENIRD---WCISRQLWWGHRIPAWYV----- 532
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 474 imTKETvnhvaDLFAEHGSNI--WF-EREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVL----ETRPELS 546
Cdd:PLN02381 533 --TLED-----DQLKELGSYNdhWVvARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLgwpdDTDDLKA 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 547 F-PADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVK-------------- 611
Cdd:PLN02381 606 FyPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleeg 685
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 612 -------------QK----------GADIARLWVSSTDYLADvRISDEILKQTSdvYR----KIRNTLRFMLGNI-NDFN 663
Cdd:PLN02381 686 nldpkelvvakegQKkdfpngiaecGTDALRFALVSYTAQSD-KINLDILRVVG--YRqwcnKLWNAVRFAMSKLgDDYT 762
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 664 P----DTDSIPES--ELLEVdrylLNRLREFTASTINNYENFDYLNI------YQEVQNFINVELSNFYLDygkdilyiE 731
Cdd:PLN02381 763 PpatlSVETMPFSckWILSV----LNKAISKTVSSLDAYEFSDAASTvyswwqYQFCDVFIEAIKPYFAGD--------N 830
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613185678 732 QRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTP----HVKEESVHLADMPKVVE 789
Cdd:PLN02381 831 PEFASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPqpkdHTRKDSIMISEYPSAVE 892
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
24-795 |
3.48e-42 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 166.38 E-value: 3.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 24 EPQIQEKWDAEDQYHKALEKNKGN----ETFilhdgpPYANGNLHMGHALNKILKDFIVRYKTMQGFyapYV--P-GWDT 96
Cdd:COG0495 11 EKKWQKYWEENGTFKADEDSSKPKyyvlDMF------PYPSGRLHMGHVRNYTIGDVVARYKRMQGY---NVlhPmGWDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 97 HGLPIEQALTKKGVDRkkmstaefrekcKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLI 176
Cdd:COG0495 82 FGLPAENAAIKNGVHP------------AEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 177 YKGKKPVYWSPSSESSLA------------EAEIE-------------YHDK------------------------RSAS 207
Cdd:COG0495 150 YRKEAPVNWCPVDQTVLAneqvidgrcwrcGAPVEkkelpqwflkitdYADEllddldkldgwpekvktmqrnwigRSEG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 208 IYVAFDVKddkgvvDADAKFIIWTTTPWTI--PSNVAITV-HP---ELKYGQYNVNGEKYiIAEALSDAVAEALDWDKas 281
Cdd:COG0495 230 AEVDFPVE------GSDEKITVFTTRPDTLfgATFMVLAPeHPlvkELATPEQNAAVAAF-IEEAKKKSEIERTSETK-- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 282 iklEKE--YTGKeleYVVaqHPFlDRESL-------VINGYhvttdaGTGCVHTAPGHGEDDYIVGQKYELP---VISPI 349
Cdd:COG0495 301 ---EKTgvFTGL---YAI--NPL-TGEKIpiwiadyVLMDY------GTGAVMAVPAHDQRDFEFAKKYGLPikqVIAPE 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 350 DD------KGVFTEEG-----GQFEGMFYDKANKAVTDLLTEKGallkldfithsyphdWRTKKpvifratpqwfasisk 418
Cdd:COG0495 366 DGddpdilEEAYTGDGvlinsGEFDGLDSEEAKEAIIEWLEEKG---------------LGKRK---------------- 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 419 vrhdildaienTNFKvnwgktriynmVRDrgeWVISRQRVWGVPLPVFYAENGEIIMTKEtvnhvadlfaehgsniwfer 498
Cdd:COG0495 415 -----------VNYR-----------LRD---WLISRQRYWGEPIPIIHCEDCGVVPVPE-------------------- 449
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 499 eaKDL---LPEG--FT-HPGSP---------------NGTFTKETDIMDVWFDSG-------SSHRGVLETRPELS---F 547
Cdd:COG0495 450 --DQLpveLPEDvdFDpTGGSPlarapewvnvtcpkcGGPARRETDTMDTFVDSSwyylrytDPHNDEAPFDPEAAnywL 527
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 548 PADMYLEGSDQ------Y-RGWfnssittsvaTR-----G-VS---PYKFLLSHGFVMD--------GEGKKMSKSLGNV 603
Cdd:COG0495 528 PVDQYIGGIEHailhllYaRFF----------TKvlrdlGlVSfdePFKRLLTQGMVLEvgkdgvviGGIEKMSKSKGNV 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 604 IVPDQVVKQKGADIARLWV-SSTDYLADVRISDeilkqtSDV---YRKIRNTLRFM--LGNINDFNPDTDSIPESELlev 677
Cdd:COG0495 598 VDPDEIIEKYGADTLRLFEmFAGPPERDLEWSD------SGVegaYRFLNRVWRLVvdEAEALKLDVADLSEADKEL--- 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 678 dRYLLNRlreftasTI----NNYENFdylniyqevqNFiNV------ELSNFYLDYGKDilyIEQRDSHIRRSMQTVLyq 747
Cdd:COG0495 669 -RRALHK-------TIkkvtEDIERL----------RF-NTaiaalmELVNALYKAKDS---GEADRAVLREALETLV-- 724
|
890 900 910 920
....*....|....*....|....*....|....*....|....*...
gi 613185678 748 ilvdmtKLLAPILVHTAEEVWSHTPHvkEESVHLADMPkvvEVDQALL 795
Cdd:COG0495 725 ------LLLAPFAPHIAEELWERLGH--EGSVADAPWP---EADEAAL 761
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
63-842 |
1.01e-35 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 146.17 E-value: 1.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 63 LHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIeQALT---KKGvDRKKMST------------AEFR--EKCK 125
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-LGIAeriARG-DPETIELykslygipeeelEKFKdpEYIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 126 EFALEQIelqKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEaeieyHDKR- 204
Cdd:PRK12300 79 EYFSEEA---KEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGD-----HDLLd 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 205 --SASI--YVAFDVKDDKGVVdadakFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIaealSDAVAEALDWDKA 280
Cdd:PRK12300 151 geEPEIveYTLIKFEESEDLI-----LPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWIV----SKEAAEKLSFQDR 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 281 SIKLEKEYTGKELEYVVAQHPFLDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIV-----GQKYELPVISPI------ 349
Cdd:PRK12300 222 DVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYVAlrdlkKNKELLDVIEPIplieve 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 350 -------------------DD----------------KGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKL-DFiths 393
Cdd:PRK12300 302 gygefpakevveklgiksqEDpeleeatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMyEF---- 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 394 yphdwrTKKPVIFRA-TP--------QWFASIS----KVR-HDILDAIE--------NTNFKVNWGKtriynmvrdrgEW 451
Cdd:PRK12300 378 ------SNRPVYCRCgTEcvvkvvkdQWFIDYSdpewKELaHKALDNMEiipeeyrkEFENTIDWLK-----------DR 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 452 VISRQRVWGVPLPVfyaENGEII---------MTKETVNHvadlFAEHGsNIwferEAKDLLPEGFTHpgspngTFTKET 522
Cdd:PRK12300 441 ACARRRGLGTRLPW---DEEWIIeslsdstiyMAYYTIAH----KIREY-GI----KPEQLTPEFFDY------VFLGKG 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 523 DIMDVWFDSGSSHRGVLETRPELSF--PADMYLEGSDQyrgwfnssittsvatrgVS---PYkFLLSH------------ 585
Cdd:PRK12300 503 DPEEVSKKTGIPKEILEEMREEFLYwyPVDWRHSGKDL-----------------IPnhlTF-FIFNHvaifpeekwprg 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 586 ----GFVMDgEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSST-DYLADVRISDEILKQTSDVYRKIRNtlrFMLGNIn 660
Cdd:PRK12300 565 ivvnGFVLL-EGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSaELLQDADWREKEVESVRRQLERFYE---LAKELI- 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 661 dfnpdtDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVqnfinvelsnFYLDYgKDILYIEQRDSHIRRS 740
Cdd:PRK12300 640 ------EIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEA----------FYELL-NDLRWYLRRVGEANNK 702
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 741 mqtVLYQILVDMTKLLAPILVHTAEEVWSHTPHvkEESVHLADMPkvvEVDQALLDKwrTFMNLRDDVNRALETARN-EK 819
Cdd:PRK12300 703 ---VLREVLEIWIRLLAPFTPHLAEELWHKLGG--EGFVSLEKWP---EPDESKIDE--EAELAEEYVKRLIEDIREiLK 772
|
890 900
....*....|....*....|....
gi 613185678 820 VIGKSLE-AKVTIASNDKFNASEF 842
Cdd:PRK12300 773 VAKIKPKkVYIYVAPDWKYEVLEI 796
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
635-760 |
5.48e-34 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 126.08 E-value: 5.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 635 DEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSipeSELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINV 714
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGTQPKWDN---ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 613185678 715 ElsNFYLDYGKDILYIEqrdsHIRRSMQTVLYQILVDMTKLLAPIL 760
Cdd:cd07375 78 L--NWYLDELKPALQTE----ELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
24-786 |
4.76e-32 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 134.57 E-value: 4.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 24 EPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANG-NLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIE 102
Cdd:PLN02563 86 EPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGaGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAE 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 103 Q-AL---------TKKGVDRkkmstaeFREKCKEfaleqielqkkdfrrLGVRGDFNDPYITLKPEYEAAQIRIFGEMAD 172
Cdd:PLN02563 166 QyAIetgthpkitTLKNIAR-------FRSQLKS---------------LGFSYDWDREISTTEPEYYKWTQWIFLQLLK 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 173 KGLIYKGKKPVYWSPSSESSLAEAEI-------------------------EYHDK-----------------------R 204
Cdd:PLN02563 224 RGLAYQAEVPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYADRlledlddldwpesikemqrnwigR 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 205 SASIYVAFDVKDDKGvVDADAKFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASikL 284
Cdd:PLN02563 304 SEGAELDFSVLDGEG-KERDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTE--L 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 285 EKEYTGKeLEYVVAQHPFLDRESLVINGYHVTTDAGTGCVHTAPGHGEDDYIVGQKYELP---VISPIDDKGV-----FT 356
Cdd:PLN02563 381 QKEKTGV-FTGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPikwVVKPADGNEDdaekaYT 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 357 EEG---------GQFEGMFYDKANKAVTDLLTEKGAllkldfithsyphdwrtkkpvifratpqwfasiskvrhdildai 427
Cdd:PLN02563 460 GEGvivnssssgLDINGLSSKEAAKKVIEWLEETGN-------------------------------------------- 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 428 entnfkvnwGKTRIYNMVRDrgeWVISRQRVWGVPLPVFYAEN-GEIIMTKET-------------------------VN 481
Cdd:PLN02563 496 ---------GKKKVNYKLRD---WLFARQRYWGEPIPVVFLEDsGEPVPVPESdlpltlpelddftptgtgepplakaVS 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 482 HVADLFAEHGSniWFEREAkDLLPE---------GFTHPGSPNGTFTKETDI----MDVWFdSGSSHR------------ 536
Cdd:PLN02563 564 WVNTVDPSSGK--PARRET-NTMPQwagscwyylRFMDPKNSNALVDKEKEKywmpVDLYV-GGAEHAvlhllyarfwhk 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 537 -----GVLETrPElsfP------ADMYLeGSDQYRGWFNSS---ITTSVATRGVSPYKFLLSH--------GFVMDGEGK 594
Cdd:PLN02563 640 vlydiGVVST-KE---PfqclvnQGMIL-GEVEYTAFKDSDgeyVSADTADRLGELQQEKIPEekviksgdSFVLKDDPS 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 595 --------KMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEilKQTSDVYRKIRNTLRFMLGNIND---FN 663
Cdd:PLN02563 715 irliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWST--SGVEGVHRFLGRTWRLVVGAPLPdgsFR 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 664 PDTDSIPESELLEVDRYLLNRLREFTASTinnyENFDYLNIYQEVQNFINVelsnfyldygkdilyIEQRDSHIRrsmqt 743
Cdd:PLN02563 793 DGTVVTDEEPSLEQLRLLHKCIAKVTEEI----ESTRFNTAISAMMEFTNA---------------AYKWDKVPR----- 848
|
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 613185678 744 vlyQILVDMTKLLAPILVHTAEEVWSHTPHvkEESVHLADMPK 786
Cdd:PLN02563 849 ---EAIEPFVLLLSPYAPHLAEELWFRLGH--SNSLAYEPWPE 886
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
678-831 |
1.89e-31 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 119.82 E-value: 1.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 678 DRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDSHIrrsmQTVLYQILVDMTKLLA 757
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSRA----QTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613185678 758 PILVHTAEEVWshtphvKEESVHLADMPKVVEVDQALLDKwrtFMNLRDDVNRALETARNEKVIGKSLEAKVTI 831
Cdd:pfam08264 77 PFMPFITEELW------QKESIHLAPWPEDAELEEAELEE---AFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
634-797 |
2.92e-21 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 92.23 E-value: 2.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 634 SDEILKQT-SDVYRKIRNTLRFMLGNIN--DFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQN 710
Cdd:cd07961 2 SEKGVREVvRKVLLPLWNAYRFFVTYANldGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 711 FInVELSNFYldygkdilyieqrdshIRRS---------------MQTVLYQILVDMTKLLAPILVHTAEEVWSH---TP 772
Cdd:cd07961 82 FI-DELTNWY----------------IRRNrkrfwgeegdddklaAYATLYEVLLTLSRLMAPFTPFITEEIYQNlrrEL 144
|
170 180
....*....|....*....|....*
gi 613185678 773 HVKEESVHLADMPkvvEVDQALLDK 797
Cdd:cd07961 145 GDAPESVHLLDWP---EVDESLIDE 166
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
57-185 |
2.40e-19 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 90.00 E-value: 2.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 57 PYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMsTAEFREKCKEfaleqielqk 136
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDW-TEYNIKKMKE---------- 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 613185678 137 kDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYW 185
Cdd:cd00812 78 -QLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
57-199 |
2.63e-18 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 89.40 E-value: 2.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 57 PYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDrkkmstaefrekCKEFALEQIELQK 136
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGIT------------PQELVDRIHAEFK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613185678 137 KDFRRLGVRgdfNDPYI-TLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIE 199
Cdd:COG0143 78 ELFEKLGIS---FDNFIrTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDRYVE 138
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
57-199 |
1.34e-17 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 85.80 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 57 PYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRkkmstaefrekcKEFALEQIELQK 136
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITP------------EELVDRYHEIHR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613185678 137 KDFRRLGVRgdfNDPYI--TLKPEYEAAQiRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIE 199
Cdd:pfam09334 76 EDFKKFNIS---FDDYGrtTSERHHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
57-201 |
1.59e-17 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 84.51 E-value: 1.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 57 PYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRkkmstaefrekcKEFALEQIELQK 136
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTP------------QELCDKYHEIFK 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613185678 137 KDFRRLGVrgDFNDPYITLKPE-YEAAQiRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYH 201
Cdd:cd00814 77 DLFKWLNI--SFDYFIRTTSPRhKEIVQ-EFFKKLYENGYIYEGEYEGLYCVSCERFLPEWREEEH 139
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
57-199 |
1.08e-14 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 77.80 E-value: 1.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 57 PYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRkkmstaefrekcKEFALEQIELQK 136
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEGLTP------------KELVDKYHEEFK 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613185678 137 KDFRRLGVRgdfNDPYI-TLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIE 199
Cdd:TIGR00398 76 DDWKWLNIS---FDRFIrTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVE 136
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
647-770 |
1.23e-13 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 68.74 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 647 KIRNTLRFMLGNINDFNPDtdSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKD 726
Cdd:cd07962 15 KLWNAARFVLMNLEDDDEP--EEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYLELVKP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 613185678 727 ILYIEqrDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSH 770
Cdd:cd07962 93 RLYGE--DEEEKKAARATLYYVLETILRLLHPFMPFITEELWQR 134
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
48-198 |
1.23e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 74.53 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 48 ETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGvdrkkMSTAEF-REKCKE 126
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAG-----ISPQELaDRNSAA 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 613185678 127 FaleqielqKKDFRRLGVRgdfNDPYI-TLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEI 198
Cdd:PRK11893 76 F--------KRLWEALNIS---YDDFIrTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESEL 137
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
58-199 |
5.22e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 69.83 E-value: 5.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 58 YANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRK----KMStAEFREKCKEFALEqie 133
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQeyvdEIS-AGFKELWKKLDIS--- 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 613185678 134 lqkkdfrrlgvrgdfNDPYI-TLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIE 199
Cdd:PRK12267 90 ---------------YDKFIrTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLV 141
|
|
| zf-FPG_IleRS |
pfam06827 |
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of ... |
883-910 |
1.86e-10 |
|
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.
Pssm-ID: 429140 [Multi-domain] Cd Length: 28 Bit Score: 56.44 E-value: 1.86e-10
10 20
....*....|....*....|....*...
gi 613185678 883 GEKCERCWNYSEDLGAVDELTHLCPRCQ 910
Cdd:pfam06827 1 GEKCPRCWTYIEKVGVGGRSTYFCPRCQ 28
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
411-625 |
3.60e-10 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 62.27 E-value: 3.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 411 QWFASIS--KVRHDILDAIENTNFKvnWGKTRiyNMVRDrgeWV-ISRQRVWGVPLPVfyaengeiimtKETVNHVADlf 487
Cdd:cd00812 131 QWFLKYSetEWKEKLLKDLEKLDGW--PEEVR--AMQEN---WIgCSRQRYWGTPIPW-----------TDTMESLSD-- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 488 aehgSNIWFEReakdllpegFTHPgspngTFTKETDIMDVWFDsgsshrgvletRPELSF--PADMYLEGSDQ------- 558
Cdd:cd00812 191 ----STWYYAR---------YTDA-----HNLEQPYEGDLEFD-----------REEFEYwyPVDIYIGGKEHapnhlly 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 559 YRgwFNssiTTSVATRGVS---PYKFLLSHGFVMdGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSST 625
Cdd:cd00812 242 SR--FN---HKALFDEGLVtdePPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFA 305
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
57-178 |
7.97e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 62.48 E-value: 7.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 57 PYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIeqaltkkgvdrkkMSTAEfREKC--KEFALEQIEL 134
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPI-------------MLKAE-KEGItpEELIARYHAE 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 613185678 135 QKKDFRRLGVrgDFNDPYITLKPE-YEAAQiRIFGEMADKGLIYK 178
Cdd:PRK00133 77 HKRDFAGFGI--SFDNYGSTHSEEnRELAQ-EIYLKLKENGYIYE 118
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
583-783 |
4.48e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 59.90 E-value: 4.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 583 LSHGFVMDgEGKKMSKSLGNVIVPDQVVKQKGADIARLwvsstdYLA-DVRI-SDEILKQTSDVYRkIRNTLRFMLGNIN 660
Cdd:PRK11893 288 FAHGFLTL-DGEKMSKSLGNVIDPFDLVDEYGVDAVRY------FLLrEIPFgQDGDFSREAFINR-INADLANDLGNLA 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 661 D--FNPDTDS----IPE-SELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINveLSNFYLDygkdilyiEQ- 732
Cdd:PRK11893 360 QrtLSMIAKNfdgkVPEpGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVR--AANKYID--------EQa 429
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 613185678 733 ----RDSHIRRsMQTVLYqILVDMTK----LLAPILVHTAEEVWSHTPHVKEESVHLAD 783
Cdd:PRK11893 430 pwslAKTDPER-LATVLY-TLLEVLRgiavLLQPVMPELAAKILDQLGVEEDENRDFAA 486
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
204-379 |
5.46e-09 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 56.79 E-value: 5.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 204 RSASIYVAFDVKDDkgvvdaDAKFIIWTTTPWTIPSNVAITVHPE----LKYGQYNVNGEKYIiAEALSDAVAEAldwdk 279
Cdd:pfam13603 6 RSEGAEITFPVEGT------DEKIEVFTTRPDTLMGVTFVALAPEhplvEKLAEKNPEVAAFI-EECKNTSEIER----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 280 ASIKLEKE--YTGKeleYVVaqHPFlDRESLVI---NgyHVTTDAGTGCVHTAPGHGEDDYIVGQKYELP---VISPIDD 351
Cdd:pfam13603 74 TSETKEKEgvFTGL---YAI--HPI-TGEKIPIwiaN--FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPikpVIQPEDG 145
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 613185678 352 KG-------VFTEEG-----GQFEGMFYDKANKAVTDLLT 379
Cdd:pfam13603 146 DLdldimteAYTEEGilvnsGEFDGLDSEEAKEAIIKKLE 185
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
677-769 |
2.22e-08 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 52.98 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 677 VDRYLLNRLREFTASTINNYENFDYLNIYQEVQNfinvELSNfYLDYgkdilYIEQRDSHIRRSmqtVLYQILVDMTKLL 756
Cdd:cd07959 36 IDRWLLSRLNRLIKETTEAYENMQFREALKEGLY----ELQN-DLDW-----YRERGGAGMNKD---LLRRFIEVWTRLL 102
|
90
....*....|...
gi 613185678 757 APILVHTAEEVWS 769
Cdd:cd07959 103 APFAPHLAEEIWH 115
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
585-671 |
1.60e-07 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 54.72 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 585 HGFVMDgEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLRFMLGNINDFNP 664
Cdd:COG0215 256 NGFLTV-NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALGAADS 334
|
....*..
gi 613185678 665 DTDSIPE 671
Cdd:COG0215 335 SAEEIEE 341
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
405-619 |
6.71e-06 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 49.07 E-value: 6.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 405 IFRATPQWFASISKVRHDILDAIENtNFKVNWGKTRIyNMVRDR-----GEWVISRQRV-WGVPLP-----VFY----AE 469
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEK-NPDFIWPENAR-NEVLSWlkeglKDLSITRDLFdWGIPVPldpgkVIYvwfdAL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 470 NGEIIMTKEtvnhvadLFAEHGSNIWFERE--------AKDLLPegfthpgspngtftketdimdvwfdsgssHRGVLet 541
Cdd:cd00814 211 IGYISATGY-------YNEEWGNSWWWKDGwpelvhfiGKDIIR-----------------------------FHAIY-- 252
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 613185678 542 rpelsFPAdmYLEGSdqyrgwfnssittsvatrGVSPYKFLLSHGFVMDgEGKKMSKSLGNVIVPDQVVKQKGADIAR 619
Cdd:cd00814 253 -----WPA--MLLGA------------------GLPLPTRIVAHGYLTV-EGKKMSKSRGNVVDPDDLLERYGADALR 304
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
462-722 |
7.19e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 46.63 E-value: 7.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 462 PLPVFYAENGEIIMTKETVNHVADlfaehgsniWFEREAKDL-LPEGFTHPGSPNGTFTKETdiMDVWFD---------S 531
Cdd:PLN02224 236 PLEDILAQNPRFVQPSYRLNEVQS---------WIKSGLRDFsISRALVDWGIPVPDDDKQT--IYVWFDallgyisalT 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 532 GSSHRGVLETRPELSFPADMYLEGSDQYRgwFNSSITTS-VATRGVSPYKFLLSHGFVMDgEGKKMSKSLGNVIVPDQVV 610
Cdd:PLN02224 305 EDNKQQNLETAVSFGWPASLHLIGKDILR--FHAVYWPAmLMSAGLELPKMVFGHGFLTK-DGMKMGKSLGNTLEPFELV 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 611 KQKGADIARLWV-------SSTDYLAD--VRISDEILKQTsdvyrkIRNTLRFMLGNINDfNPDTDSIPESELLEVDRYL 681
Cdd:PLN02224 382 QKFGPDAVRYFFlrevefgNDGDYSEDrfIKIVNAHLANT------IGNLLNRTLGLLKK-NCESTLVEDSTVAAEGVPL 454
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 613185678 682 LNRLREFTASTINNYENFDYLNIYQEVQNFINVelSNFYLD 722
Cdd:PLN02224 455 KDTVEKLVEKAQTNYENLSLSSACEAVLEIGNA--GNTYMD 493
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
575-616 |
9.27e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 46.33 E-value: 9.27e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 613185678 575 GVSPYKFLLSHG-FVMDGEgkKMSKSLGNVIVPDQVVKQKGAD 616
Cdd:PRK12267 280 GLPLPKKVFAHGwWLMKDG--KMSKSKGNVVDPEELVDRYGLD 320
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
567-641 |
1.40e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 41.58 E-value: 1.40e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613185678 567 ITTSVATRGVSPYKFLLSHGFVMDgEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQT 641
Cdd:pfam01406 226 IAQSEAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRSPLDFSEELLEQA 299
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
592-749 |
1.72e-03 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 41.94 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 592 EGKKMSKSLGNVIVPDQVVKQKGADIARL------WVSSTDYladvriSDEILKQTSDVYRKIRNTLRFMLGNINDFNPd 665
Cdd:PTZ00399 312 KGLKMSKSLKNFITIRQALSKYTARQIRLlfllhkWDKPMNY------SDESMDEAIEKDKVFFNFFANVKIKLRESEL- 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613185678 666 TDSIPESELlevDRYLLNRLREfTASTINNY--ENFDYLNIYQEVQNFINVelSNFYLDYGKDILYieqrdsHIRRSMQT 743
Cdd:PTZ00399 385 TSPQKWTQH---DFELNELFEE-TKSAVHAAllDNFDTPEALQALQKLISA--TNTYLNSGEQPSA------PLLRSVAQ 452
|
....*.
gi 613185678 744 VLYQIL 749
Cdd:PTZ00399 453 YVTKIL 458
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
577-653 |
4.14e-03 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 40.86 E-value: 4.14e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 613185678 577 SPYKFLLSHGFV-MDGEgkKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLR 653
Cdd:PRK14535 491 SHVKYWLHNGFIrVDGE--KMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDAKGALTRLYTTLK 566
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
583-627 |
5.34e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 39.48 E-value: 5.34e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 613185678 583 LSHGFV-MDGEgkKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDY 627
Cdd:cd00672 163 LHTGHLtIDGE--KMSKSLGNFITVRDALKKYDPEVLRLALLSSHY 206
|
|
| |
