NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2753918737|dbj|GAB0346063|]
View 

LytTR family DNA-binding domain-containing protein [Staphylococcus pseudintermedius]

Protein Classification

response regulator transcription factor( domain architecture ID 14434868)

response regulator transcription factor belonging to the LytTR/AlgR family with signal receiver (REC) and DNA-binding domains, that may be part of a two-component regulatory system

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-130 5.26e-42

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


:

Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 139.29  E-value: 5.26e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENYIMIE--EKPMEIELATNDpyaILETSKNMTDIGCYFLDIQLE-SDINGIKLGSEIRK 77
Cdd:cd17533     1 MNIFILEDDKIQRVRLEEIIENILKIEniEYVIELTGKTEE---LLEKIKERGKNGIYFLDIDIKmEEKNGLEVAQKIRK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2753918737  78 HDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDD-PEELRTRIIDCLETALKR 130
Cdd:cd17533    78 YDPYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLkLEEFKKRIEECIKYAQKN 131
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 1.19e-15

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


:

Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 69.93  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737 152 VYVNYDDVMFFESspKSHRLIAHLDNRQIEFYGNLKEL-AQLD-DRFFRCHNSYVLNRRNITSVDTKER---IAYFKNEE 226
Cdd:pfam04397   4 ILVPIDDILYIEA--EDKYVTIHTANGEYLTRGTLKELeEKLPpDGFFRCHRSYLVNLNKIKEIDPDFNgtyELTLKNGE 81

                          90
                  ....*....|..
gi 2753918737 227 FCYVSVRNLKKI 238
Cdd:pfam04397  82 KIPVSRRYLKEL 93
 
Name Accession Description Interval E-value
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-130 5.26e-42

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 139.29  E-value: 5.26e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENYIMIE--EKPMEIELATNDpyaILETSKNMTDIGCYFLDIQLE-SDINGIKLGSEIRK 77
Cdd:cd17533     1 MNIFILEDDKIQRVRLEEIIENILKIEniEYVIELTGKTEE---LLEKIKERGKNGIYFLDIDIKmEEKNGLEVAQKIRK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2753918737  78 HDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDD-PEELRTRIIDCLETALKR 130
Cdd:cd17533    78 YDPYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLkLEEFKKRIEECIKYAQKN 131
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-238 4.44e-39

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 134.94  E-value: 4.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENYimieeKPMEIELATNDPYAILET-SKNMTDIgcYFLDIQLeSDINGIKLGSEIRKHD 79
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELlEEHKPDL--VFLDIQM-PGLDGFELARQLRELD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737  80 PVGNIIFVTSHSELTYLTFvyKVAAMDFIFKD-DPEELRTRIIDCLETALKRLDLLTKDHTVETLELKRGTSSVYVNYDD 158
Cdd:COG3279    74 PPPPIIFTTAYDEYALEAF--EVNAVDYLLKPiDEERLAKALEKAKERLEAKAAAEASPEEKDRIFVKSGGKLVKIPLDD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737 159 VMFFESSpkSHRLIAHLDNRQIEFYGNLKEL-AQLD-DRFFRCHNSYVLNRRNITSVDTKER-IAYFKNEEFCYVSVRNL 235
Cdd:COG3279   152 ILYIEAE--GNYVKIHTKDKKYLVRKTLKELeEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNgEVVLKNGEEIPVSRRYK 229


                  ...
gi 2753918737 236 KKI 238
Cdd:COG3279   230 KEF 232
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-120 6.92e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 84.13  E-value: 6.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSIIENYIMIeekpmeIELATN--DPYAILETSKnmtdIGCYFLDIQLeSDINGIKLGSEIRKHDP 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYV------VAEADDgkEALELLKEER----PDLILLDINM-PGMDGLELLKRIRRRDP 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2753918737  81 VGNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRI 120
Cdd:pfam00072  70 TTPVIILTAHGDEDDAVEALEAGADDFLSKPfDPDELLAAI 110
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 1.19e-15

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 69.93  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737 152 VYVNYDDVMFFESspKSHRLIAHLDNRQIEFYGNLKEL-AQLD-DRFFRCHNSYVLNRRNITSVDTKER---IAYFKNEE 226
Cdd:pfam04397   4 ILVPIDDILYIEA--EDKYVTIHTANGEYLTRGTLKELeEKLPpDGFFRCHRSYLVNLNKIKEIDPDFNgtyELTLKNGE 81

                          90
                  ....*....|..
gi 2753918737 227 FCYVSVRNLKKI 238
Cdd:pfam04397  82 KIPVSRRYLKEL 93
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 2.35e-14

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 66.44  E-value: 2.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737  152 VYVNYDDVMFFESSPksHRLIAHLDNRQIEFYGNLKELAQL--DDRFFRCHNSYVLNRRNITSVDTKER---IAYFKNEE 226
Cdd:smart00850   4 VLIPLDDILYIEAEG--NYVTVHTKDGTYLVRGTLKELEERldPDNFFRIHRSYIVNLDHIKEIEPWFNgtyLLILKNGE 81

                           90
                   ....*....|..
gi 2753918737  227 FCYVSVRNLKKI 238
Cdd:smart00850  82 EVPVSRRYLKEL 93
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-125 2.06e-03

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 38.68  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   2 KILICEDDPKQReRMVSIIenyimIEEKPMEIELATNDPYAILETSKNMTDIgcYFLDIQLESdINGIKLGSEIRKHDPV 81
Cdd:PRK11361    6 RILIVDDEDNVR-RMLSTA-----FALQGFETHCANNGRTALHLFADIHPDV--VLMDIRMPE-MDGIKALKEMRSHETR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2753918737  82 GNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRIIDCLE 125
Cdd:PRK11361   77 TPVILMTAYAEVETAVEALRCGAFDYVIKPfDLDELNLIVQRALQ 121
 
Name Accession Description Interval E-value
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-130 5.26e-42

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 139.29  E-value: 5.26e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENYIMIE--EKPMEIELATNDpyaILETSKNMTDIGCYFLDIQLE-SDINGIKLGSEIRK 77
Cdd:cd17533     1 MNIFILEDDKIQRVRLEEIIENILKIEniEYVIELTGKTEE---LLEKIKERGKNGIYFLDIDIKmEEKNGLEVAQKIRK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2753918737  78 HDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDD-PEELRTRIIDCLETALKR 130
Cdd:cd17533    78 YDPYAIIIFVTTHSEFAPLTFEYKVAALDFILKPLkLEEFKKRIEECIKYAQKN 131
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-238 4.44e-39

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 134.94  E-value: 4.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENYimieeKPMEIELATNDPYAILET-SKNMTDIgcYFLDIQLeSDINGIKLGSEIRKHD 79
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKY-----PDLEVVGEASNGEEALELlEEHKPDL--VFLDIQM-PGLDGFELARQLRELD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737  80 PVGNIIFVTSHSELTYLTFvyKVAAMDFIFKD-DPEELRTRIIDCLETALKRLDLLTKDHTVETLELKRGTSSVYVNYDD 158
Cdd:COG3279    74 PPPPIIFTTAYDEYALEAF--EVNAVDYLLKPiDEERLAKALEKAKERLEAKAAAEASPEEKDRIFVKSGGKLVKIPLDD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737 159 VMFFESSpkSHRLIAHLDNRQIEFYGNLKEL-AQLD-DRFFRCHNSYVLNRRNITSVDTKER-IAYFKNEEFCYVSVRNL 235
Cdd:COG3279   152 ILYIEAE--GNYVKIHTKDKKYLVRKTLKELeEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNgEVVLKNGEEIPVSRRYK 229


                  ...
gi 2753918737 236 KKI 238
Cdd:COG3279   230 KEF 232
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-120 6.92e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 84.13  E-value: 6.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSIIENYIMIeekpmeIELATN--DPYAILETSKnmtdIGCYFLDIQLeSDINGIKLGSEIRKHDP 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYV------VAEADDgkEALELLKEER----PDLILLDINM-PGMDGLELLKRIRRRDP 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2753918737  81 VGNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRI 120
Cdd:pfam00072  70 TTPVIILTAHGDEDDAVEALEAGADDFLSKPfDPDELLAAI 110
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 1.19e-15

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 69.93  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737 152 VYVNYDDVMFFESspKSHRLIAHLDNRQIEFYGNLKEL-AQLD-DRFFRCHNSYVLNRRNITSVDTKER---IAYFKNEE 226
Cdd:pfam04397   4 ILVPIDDILYIEA--EDKYVTIHTANGEYLTRGTLKELeEKLPpDGFFRCHRSYLVNLNKIKEIDPDFNgtyELTLKNGE 81

                          90
                  ....*....|..
gi 2753918737 227 FCYVSVRNLKKI 238
Cdd:pfam04397  82 KIPVSRRYLKEL 93
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 152-238 2.35e-14

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 66.44  E-value: 2.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737  152 VYVNYDDVMFFESSPksHRLIAHLDNRQIEFYGNLKELAQL--DDRFFRCHNSYVLNRRNITSVDTKER---IAYFKNEE 226
Cdd:smart00850   4 VLIPLDDILYIEAEG--NYVTVHTKDGTYLVRGTLKELEERldPDNFFRIHRSYIVNLDHIKEIEPWFNgtyLLILKNGE 81

                           90
                   ....*....|..
gi 2753918737  227 FCYVSVRNLKKI 238
Cdd:smart00850  82 EVPVSRRYLKEL 93
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-120 1.59e-09

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 55.30  E-value: 1.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENY---IMIEEKPME-IELATNDPYAILetsknmtdigcyFLDIQLeSDINGIKLGSEIR 76
Cdd:COG3706     2 ARILVVDDDPTNRKLLRRLLEAAgyeVVEAADGEEaLELLQEHRPDLI------------LLDLEM-PDMDGLELCRRLR 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2753918737  77 KHDPVGN--IIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRI 120
Cdd:COG3706    69 ADPRTADipIIFLTALDDEEDRARALEAGADDYLTKPfDPEELLARV 115
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-110 4.32e-09

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 52.47  E-value: 4.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   2 KILICEDDPKQRERMVSIIENYIMIEEkpmeIELATNDPYAILETSKNMTDIgcYFLDIQLEsDINGIKLGSEIRKHDPV 81
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAGFEV----VGEAENGEEALELLEEHKPDL--VITDINMP-GMDGLELLEAIRELDPD 73

                          90       100
                  ....*....|....*....|....*....
gi 2753918737  82 GNIIFVTSHSELTYLTFVYKVAAMDFIFK 110
Cdd:COG4753    74 TKIIILSGYSDFEYAQEAIKLGADDYLLK 102
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-137 6.59e-08

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 49.97  E-value: 6.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENyimiEEKPMEIELATNDPYAILETSKNMTDIGcyFLDIQLEsDINGIKLGSEIRKHDP 80
Cdd:COG4565     4 IRVLIVEDDPMVAELLRRYLER----LPGFEVVGVASSGEEALALLAEHRPDLI--LLDIYLP-DGDGLELLRELRARGP 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2753918737  81 VGNIIFVTSHSELTYLTFVYKVAAMDFIFK-DDPEELRtriiDCLETALKRLDLLTKD 137
Cdd:COG4565    77 DVDVIVITAARDPETVREALRAGVVDYLIKpFTFERLR----EALERYLEYRRLLRED 130
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-133 1.59e-07

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 51.12  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVsiienyIMIEEKPMEIELATN--DPYAILETSKnmtdIGCYFLDIQLEsDINGIKLGSEIRKH 78
Cdd:COG2204     3 ARILVVDDDPDIRRLLK------ELLERAGYEVETAASgeEALALLREEP----PDLVLLDLRMP-GMDGLELLRELRAL 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2753918737  79 DPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRIIDCLETALKRLDL 133
Cdd:COG2204    72 DPDLPVILLTGYGDVETAVEAIKAGAFDYLTKPfDLEELLAAVERALERRRLRREN 127
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-131 6.14e-07

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 46.76  E-value: 6.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSIIENYIMIEEkpmeIELATNDPYAILETSKNMTDIgcYFLDIQLeSDINGIKLGSEIRKHDPVG 82
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEI----VGEAENGEEALEAIEELKPDV--VFLDIQM-PGLDGLELAKKLSKLAKPP 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2753918737  83 NIIFVTSHSEltYLTFVYKVAAMDFIFKDDPEElrtRIIDCLETALKRL 131
Cdd:cd17532    74 LIVFVTAYDE--YAVEAFELNAVDYLLKPFSEE---RLAEALAKLRKRL 117
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-133 2.13e-06

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 47.08  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENY---IMIEEKPME-IELATNDPYAILetsknmtdigcyFLDIQLEsDINGIKLGSEIR 76
Cdd:COG3437     7 PTVLIVDDDPENLELLRQLLRTLgydVVTAESGEEaLELLLEAPPDLI------------LLDVRMP-GMDGFELLRLLR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737  77 KHDPVGNI--IFVTSHSELTYLTFVYKVAAMDFIFK-DDPEELRTRIIDCLETALKRLDL 133
Cdd:COG3437    74 ADPSTRDIpvIFLTALADPEDRERALEAGADDYLTKpFDPEELLARVRNALELRRLQREL 133
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-110 2.44e-06

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 44.91  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   4 LICEDDPKQRERMVSIIENYimieekPMEIELATNDPYAILETSKNMTDIgcYFLDIQLeSDINGIKLGSEIRKHDPVGN 83
Cdd:cd00156     1 LIVDDDPAIRELLKSLLERE------GYEVDTAADGEEALELLREERPDL--VLLDLMM-PGMDGLELLRKLRELPPDIP 71

                          90       100
                  ....*....|....*....|....*..
gi 2753918737  84 IIFVTSHSELTYLTFVYKVAAMDFIFK 110
Cdd:cd00156    72 VIVLTAKADEEDAVRALELGADDYLVK 98
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-128 3.99e-06

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 44.71  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPkqrermvsIIENYIMIEEKPME---IELATNDPYAILETSKNMTDIgcYFLDIQLESDINGIKLGSEIRK 77
Cdd:cd17534     1 KKILIVEDEA--------IIALDLKEILESLGyevVGIADSGEEAIELAEENKPDL--ILMDINLKGDMDGIEAAREIRE 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2753918737  78 HDPVgNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRIidclETAL 128
Cdd:cd17534    71 KFDI-PVIFLTAYSDEETLERAKETNPYGYLVKPfNERELKAAI----ELAL 117
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-127 1.13e-05

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 43.69  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENY---IMIEEKPME-IELATNDPYAILetsknmtdigcyFLDIQLeSDINGIKLGSEIR 76
Cdd:COG0784     6 KRILVVDDNPDNRELLRRLLERLgyeVTTAEDGAEaLELLRAGPPDLI------------LLDINM-PGMDGLELLRRIR 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2753918737  77 KHDPVGN--IIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRIIDCLETA 127
Cdd:COG0784    73 ALPRLPDipIIALTAYADEEDRERALEAGADDYLTKPvDPEELLEALRRLLARA 126
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-120 1.39e-05

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 42.88  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSIIEnyimiEEKPMEI------------ELATNDPYAILetsknmtdigcyfLDIQLEsDINGIK 70
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLE-----SEPDIEVvgeaadgeealaLLRELRPDVVL-------------MDLSMP-GMDGIE 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2753918737  71 LGSEIRKHDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRI 120
Cdd:cd17535    62 ALRRLRRRYPDLKVIVLTAHDDPEYVLRALKAGAAGYLLKDsSPEELIEAI 112
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 3-92 1.82e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 39.64  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSIIEN--YIMIEekpmeielATNDPYAiLETSKNMTDIGCYFLDIQLESDINGIKLGSEIRKHDP 80
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLEDlgYTVLE--------AASGDEA-LDLLESGPDIDLLVTDVIMPGGMNGSQLAEEARRRRP 71

                          90
                  ....*....|..
gi 2753918737  81 VGNIIFVTSHSE 92
Cdd:cd18161    72 DLKVLLTSGYAE 83
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-120 2.52e-04

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 40.71  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSiienyiMIEEKPMEIELATNDPYAILETSKNMTDIgcYFLDIQLeSDINGIKLGSEIRKHDP 80
Cdd:COG0745     2 PRILVVEDDPDIRELLAD------ALEREGYEVDTAADGEEALELLEEERPDL--ILLDLML-PGMDGLEVCRRLRARPS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2753918737  81 VGNIIFVTSHSELTyltfvYKVAAM-----DFIFKD-DPEELRTRI 120
Cdd:COG0745    73 DIPIIMLTARDDEE-----DRVRGLeagadDYLTKPfDPEELLARI 113
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-119 1.68e-03

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 36.98  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSII--ENYIMIEEKPMEielatnDPYAILETSknmtDIGCYFLDIQLeSDINGIKLGSEIRKHDP 80
Cdd:cd17619     3 ILIVEDEPVTRATLKSYFeqEGYDVSEAGDGE------EMRQILARQ----DIDLVLLDINL-PGKDGLSLTRELREQSE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2753918737  81 VGnIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTR 119
Cdd:cd17619    72 VG-IILVTGRDDEVDRIVGLEIGADDYVTKPfNPRELLVR 110
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-125 2.06e-03

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 38.68  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   2 KILICEDDPKQReRMVSIIenyimIEEKPMEIELATNDPYAILETSKNMTDIgcYFLDIQLESdINGIKLGSEIRKHDPV 81
Cdd:PRK11361    6 RILIVDDEDNVR-RMLSTA-----FALQGFETHCANNGRTALHLFADIHPDV--VLMDIRMPE-MDGIKALKEMRSHETR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2753918737  82 GNIIFVTSHSELTYLTFVYKVAAMDFIFKD-DPEELRTRIIDCLE 125
Cdd:PRK11361   77 TPVILMTAYAEVETAVEALRCGAFDYVIKPfDLDELNLIVQRALQ 121
fixJ PRK09390
response regulator FixJ; Provisional
 54-147 2.35e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 38.06  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737  54 GCYFLDIQLeSDINGIKLGSEIRKHDPVGNIIFVTSHSELTYLTFVYKVAAMDFI---FKDDpeelrtRIIDCLETALKR 130
Cdd:PRK09390   49 GCVVTDVRM-PGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIekpFEDE------RLIGAIERALAQ 121

                          90
                  ....*....|....*..
gi 2753918737 131 LDLLTKDHTVETLELKR 147
Cdd:PRK09390  122 APEAAKSEAVAADIRAR 138
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 3-132 2.76e-03

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 36.55  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   3 ILICEDDPKQRERMVSIIENyimiEEKPME-IELATN--DPYAILEtsKNMTDIgcYFLDIQLeSDINGIKLGSEIRKHD 79
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDW----EELGFEvVGEAENgeEALELIE--EHKPDI--VITDIRM-PGMDGLELIEKIRELY 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2753918737  80 PVGNIIFVTSHSELTYLtfvyKVA----AMDFIFK-DDPEELrtriIDCLETALKRLD 132
Cdd:cd17536    72 PDIKIIILSGYDDFEYA----QKAirlgVVDYLLKpVDEEEL----EEALEKAKEELD 121
PRK14084 PRK14084
DNA-binding response regulator;
1-110 4.16e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 37.42  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2753918737   1 MKILICEDDPKQRERMVSIIENYIMIEEkpmeIELATNdpyaILETSKNM--TDIGCYFLDIQLeSDINGIKLGSEIRKH 78
Cdd:PRK14084    1 MKALIVDDEPLARNELTYLLNEIGGFEE----INEAEN----VKETLEALliNQYDIIFLDINL-MDESGIELAAKIQKM 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2753918737  79 DPVGNIIFVTSHSelTYLTFVYKVAAMDFIFK 110
Cdd:PRK14084   72 KEPPAIIFATAHD--QFAVKAFELNATDYILK 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH