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Conserved domains on  [gi|749460529|dbj|GAM71142|]
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tetrathionate reductase subunit B [Vibrio sp. JCM 19236]

Protein Classification

4Fe-4S dicluster domain-containing protein( domain architecture ID 11586797)

4Fe-4S dicluster domain-containing protein such as Salmonella enterica thiosulfate reductase electron transfer subunit PhsB, a component of the PhsABC thiosulfate reductase that catalyzes the reduction of thiosulfate to sulfite and hydrogen sulfide, with menaquinol as the sole electron donor

Gene Ontology:  GO:0016491|GO:0046872|GO:0051539
SCOP:  3000020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 48-220 6.56e-110

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


:

Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 314.47  E-value: 6.56e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVLV 127
Cdd:cd10551    1 MVIDLRKCIGCGACVVACKAENNVPPGVFRNRVLEYEVGEYPNVKRTFLPVLCNHCENPPCVKVCPTGATYKREDGIVLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 128 DSDKCWGCGSCVTACPYGARFINAE------------TKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQSPA 195
Cdd:cd10551   81 DYDKCIGCRYCMAACPYGARYFNPEephefgevpvrpKGVVEKCTFCYHRLDEGLLPACVEACPTGARIFGDLDDPNSEV 160

                        170       180
                 ....*....|....*....|....*
gi 749460529 196 SKLIAENDVSVLKPSAGTKPNVFYI 220
Cdd:cd10551  161 SKLLAERRAYVLKPELGTKPKVYYI 185
 
Name Accession Description Interval E-value
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 48-220 6.56e-110

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 314.47  E-value: 6.56e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVLV 127
Cdd:cd10551    1 MVIDLRKCIGCGACVVACKAENNVPPGVFRNRVLEYEVGEYPNVKRTFLPVLCNHCENPPCVKVCPTGATYKREDGIVLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 128 DSDKCWGCGSCVTACPYGARFINAE------------TKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQSPA 195
Cdd:cd10551   81 DYDKCIGCRYCMAACPYGARYFNPEephefgevpvrpKGVVEKCTFCYHRLDEGLLPACVEACPTGARIFGDLDDPNSEV 160

                        170       180
                 ....*....|....*....|....*
gi 749460529 196 SKLIAENDVSVLKPSAGTKPNVFYI 220
Cdd:cd10551  161 SKLLAERRAYVLKPELGTKPKVYYI 185
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 42-220 9.77e-97

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 281.06  E-value: 9.77e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  42 SGKRWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKRE 121
Cdd:COG0437    2 SMKRYGMVIDLTKCIGCRACVVACKEENNLPVGVTWRRVRRYEEGEFPNVEWLFVPVLCNHCDDPPCVKVCPTGATYKRE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 122 DGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQSPASKLIAE 201
Cdd:COG0437   82 DGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCADRLDEGLLPACVEACPTGALVFGDLDDPESEVSKRLAE 161

                        170
                 ....*....|....*....
gi 749460529 202 NDVSVLKPSAGTKPNVFYI 220
Cdd:COG0437  162 LPAYRLLPELGTKPSVYYL 180
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
30-237 6.11e-92

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 271.36  E-value: 6.11e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  30 SQPKNSL---KQQSGSGKRWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEV--KSYPDTRRSFLPRLCNHCE 104
Cdd:PRK14993  25 AEAKFPFspeRHEGSPRHRYAMLIDLRRCIGCQSCTVSCTIENQTPQGAFRTTVNQYQVqrEGSQEVTNVLLPRLCNHCD 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 105 TPSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARI 184
Cdd:PRK14993 105 NPPCVPVCPVQATFQREDGIVVVDNKRCVGCAYCVQACPYDARFINHETQTADKCTFCVHRLEAGLLPACVESCVGGARI 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529 185 FGDLNDPQSPASKLIAE--NDVSVLKPSAGTKPNVFYIGLNHPEIA--NGEIEPNTW 237
Cdd:PRK14993 185 IGDIKDPHSRIATMLHQhrDAIKVLKPENGTSPHVFYLGLDDAFVTplMGRAQPALW 241
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 45-190 3.86e-45

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 149.11  E-value: 3.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529   45 RWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRL--------CNHCETPSCVPVCPTGA 116
Cdd:TIGR02951   1 QYGFYVDQTRCSGCKTCQIACKDKNDLEVGVLFRRVYEYEGGGWTEEGEGFHPDVfayyisisCNHCADPACVKNCPTGA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749460529  117 TYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLND 190
Cdd:TIGR02951  81 MYKReEDGLVLVDQDKCIGCRYCVWACPYGAPQYDPQQGVMGKCDGCYDRVEKGLRPACVDACPMRALDFGPIDE 155
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 95-188 6.31e-36

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 123.13  E-value: 6.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529   95 FLPRLCNHCETPSCVPVCPTGATYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPA 173
Cdd:pfam13247   5 FFPEQCRHCLNPPCKASCPVGAIYKDeETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYDRVEAGLLPA 84

                          90
                  ....*....|....*
gi 749460529  174 CAETCVGGARIFGDL 188
Cdd:pfam13247  85 CVQTCPTGAMNFGDR 99
 
Name Accession Description Interval E-value
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 48-220 6.56e-110

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 314.47  E-value: 6.56e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVLV 127
Cdd:cd10551    1 MVIDLRKCIGCGACVVACKAENNVPPGVFRNRVLEYEVGEYPNVKRTFLPVLCNHCENPPCVKVCPTGATYKREDGIVLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 128 DSDKCWGCGSCVTACPYGARFINAE------------TKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQSPA 195
Cdd:cd10551   81 DYDKCIGCRYCMAACPYGARYFNPEephefgevpvrpKGVVEKCTFCYHRLDEGLLPACVEACPTGARIFGDLDDPNSEV 160

                        170       180
                 ....*....|....*....|....*
gi 749460529 196 SKLIAENDVSVLKPSAGTKPNVFYI 220
Cdd:cd10551  161 SKLLAERRAYVLKPELGTKPKVYYI 185
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 42-220 9.77e-97

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 281.06  E-value: 9.77e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  42 SGKRWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKRE 121
Cdd:COG0437    2 SMKRYGMVIDLTKCIGCRACVVACKEENNLPVGVTWRRVRRYEEGEFPNVEWLFVPVLCNHCDDPPCVKVCPTGATYKRE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 122 DGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQSPASKLIAE 201
Cdd:COG0437   82 DGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCADRLDEGLLPACVEACPTGALVFGDLDDPESEVSKRLAE 161

                        170
                 ....*....|....*....
gi 749460529 202 NDVSVLKPSAGTKPNVFYI 220
Cdd:COG0437  162 LPAYRLLPELGTKPSVYYL 180
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
30-237 6.11e-92

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 271.36  E-value: 6.11e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  30 SQPKNSL---KQQSGSGKRWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEV--KSYPDTRRSFLPRLCNHCE 104
Cdd:PRK14993  25 AEAKFPFspeRHEGSPRHRYAMLIDLRRCIGCQSCTVSCTIENQTPQGAFRTTVNQYQVqrEGSQEVTNVLLPRLCNHCD 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 105 TPSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARI 184
Cdd:PRK14993 105 NPPCVPVCPVQATFQREDGIVVVDNKRCVGCAYCVQACPYDARFINHETQTADKCTFCVHRLEAGLLPACVESCVGGARI 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529 185 FGDLNDPQSPASKLIAE--NDVSVLKPSAGTKPNVFYIGLNHPEIA--NGEIEPNTW 237
Cdd:PRK14993 185 IGDIKDPHSRIATMLHQhrDAIKVLKPENGTSPHVFYLGLDDAFVTplMGRAQPALW 241
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 47-186 2.63e-59

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 184.30  E-value: 2.63e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  47 GMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVL 126
Cdd:cd16371    1 GFYFDQERCIGCKACEIACKDKNDLPPGVNWRRVYEYEGGEFPEVFAYFLSMSCNHCENPACVKVCPTGAITKREDGIVV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 127 VDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFG 186
Cdd:cd16371   81 VDQDKCIGCGYCVWACPYGAPQYNPETGKMDKCDMCVDRLDEGEKPACVAACPTRALDFG 140
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 48-186 9.86e-55

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 172.57  E-value: 9.86e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVksyPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVLV 127
Cdd:cd04410    1 LVVDLDRCIGCGTCEVACKQEHGLRPGPDWSRIKVIEG---GGLERAFLPVSCMHCEDPPCVKACPTGAIYKDEDGIVLI 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 749460529 128 DSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFG 186
Cdd:cd04410   78 DEDKCIGCGSCVEACPYGAIVFDPEPGKAVKCDLCGDRLDEGLEPACVKACPTGALTFG 136
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 48-222 1.94e-54

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 173.67  E-value: 1.94e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFEN-----------NAPVGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGA 116
Cdd:cd10552    1 LVIDVAKCNGCYNCFLACKDEHvgndwpgyaapQPRHGHFWMRILRRERGQYPKVDVAYLPVPCNHCDNAPCIKAAKDGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 117 TYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEG-LLPACAETCVGGARIFGDLNDPQSpa 195
Cdd:cd10552   81 VYKRDDGIVIIDPEKAKGQKQLVDACPYGAIYWNEELQVPQKCTFCAHLLDDGwKEPRCVQACPTGALRFGKLEDEEM-- 158

                        170       180
                 ....*....|....*....|....*..
gi 749460529 196 SKLIAENDVSVLKPSAGTKPNVFYIGL 222
Cdd:cd10552  159 AAKAAEEGLEVLHPELGTKPRVYYKNL 185
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 42-220 1.08e-52

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 173.26  E-value: 1.08e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  42 SGKRWGMVIDLRRCVGCQACTVACK------------------------------------------------------- 66
Cdd:cd10555    1 SKRQLAMVMDLNKCIGCQTCTVACKtlwtnrngreymywnnvetqpgkgypknwekkgggfkdkgelkpgiiptledygv 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  67 -FENNAPVGQFRT------------------WVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKR-EDGLVL 126
Cdd:cd10555   81 pWEYNHEEELFEGkggrvrpspkgdptwgpnWDEDQGAGEYPNSYYFYLPRICNHCTNPACLAACPRKAIYKReEDGIVL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 127 VDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQSPASKLIAENDVSV 206
Cdd:cd10555  161 VDQDRCRGYRYCVEACPYKKIYFNPVEQKSEKCIFCYPRIEKGVAPACARQCVGRIRFVGYLDDEESPVYKLVKKWKVAL 240

                        250
                 ....*....|....*
gi 749460529 207 -LKPSAGTKPNVFYI 220
Cdd:cd10555  241 pLHPEYGTEPNVFYV 255
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 44-220 8.83e-51

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 165.06  E-value: 8.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  44 KRWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRS----------------FLPRLCNHCETPS 107
Cdd:cd16365    1 KQFAAVFNLNKCIGCQTCTVACKNAWTYRKGQEYMWWNNVETKPGGGYPQDwevktidnggntrfffYLQRLCNHCTNPA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 108 CVPVCPTGATYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFG 186
Cdd:cd16365   81 CLAACPRGAIYKReEDGIVLIDQKRCRGYRKCVEQCPYKKIYFNGLSRVSEKCIACYPRIEGGDPTRCMSACVGRIRLQG 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 749460529 187 DLND-PQSPASKLIAENDVSV-LKPSAGTKPNVFYI 220
Cdd:cd16365  161 FLDDnPKSPVTKLIRHWKVALpLHPEYGTEPNIYYV 196
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 45-190 3.86e-45

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 149.11  E-value: 3.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529   45 RWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSYPDTRRSFLPRL--------CNHCETPSCVPVCPTGA 116
Cdd:TIGR02951   1 QYGFYVDQTRCSGCKTCQIACKDKNDLEVGVLFRRVYEYEGGGWTEEGEGFHPDVfayyisisCNHCADPACVKNCPTGA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749460529  117 TYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLND 190
Cdd:TIGR02951  81 MYKReEDGLVLVDQDKCIGCRYCVWACPYGAPQYDPQQGVMGKCDGCYDRVEKGLRPACVDACPMRALDFGPIDE 155
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 47-187 1.16e-42

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 143.89  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  47 GMVIDLRRCVGCQACTVACKFENNAPVGQF--------------RTW--VSDIEVKSYPDTRRsFLPRLCNHCETPSCVP 110
Cdd:cd10561    1 GVLYDTTRCIGCRACEVACKEWNGLPAEDTafgpgwdnprdlsaKTYtvIKRYEVETGGKGFV-FVKRQCMHCLDPACVS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 111 VCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA-RF--INAETKIAdKCTFCAHRLEEGLLPACAETCVGGARIFGD 187
Cdd:cd10561   80 ACPVGALRKTPEGPVTYDEDKCIGCRYCMVACPFNIpKYewDSANPKIR-KCTMCYDRLKEGKQPACVEACPTGALLFGK 158
SER_beta cd10556
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ...
 44-220 6.88e-42

Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier.


Pssm-ID: 319878 [Multi-domain]  Cd Length: 287  Bit Score: 144.52  E-value: 6.88e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  44 KRWGMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSY----------------------------------- 88
Cdd:cd10556   10 KQFAMVFDTNKCIACQTCTMACKSTWTSGKGQEYMWWNNVETKPYggyplgwdvrlldeeggqtwaeggvyegktifeaa 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  89 -------------------------------PDTRRS---------FLPRLCNHCETPSCVPVCPTGATYKR-EDGLVLV 127
Cdd:cd10556   90 aageqvlgyrpededwrypnigedevngertPDTGSSlpphpiwffYLPRICNHCTYPACLAACPRKAIYKReEDGIVLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 128 DSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLN---------DPQSPASKL 198
Cdd:cd10556  170 DQERCRGYRECVEACPYKKPMYNPTTRVSEKCIGCYPRIEEGDQTQCVSACIGKIRLQGFINtppdarwadDRDNPIDFL 249

                        250       260
                 ....*....|....*....|...
gi 749460529 199 IAENDVSV-LKPSAGTKPNVFYI 220
Cdd:cd10556  250 VHIKKVALpLYPQFGTEPNVYYI 272
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 51-186 7.37e-42

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 140.19  E-value: 7.37e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  51 DLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKSY---PDTRRSFLPrlCNHCETPSCVPVCPTGATYKRE-DGLVL 126
Cdd:cd10553    8 DSKRCIGCLACEVHCKVKNNLPVGPRLCRIFAVGPKMVggkPRLKFVYMS--CFHCENPWCVKACPTGAMQKREkDGIVY 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 127 VDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFG 186
Cdd:cd10553   86 VDQELCIGCKACIEACPWGIPQWNPATGKVVKCDYCMDRIDQGLKPACVTGCTTHALSFV 145
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 50-190 1.62e-40

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 136.25  E-value: 1.62e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  50 IDLRRCVGCQACTVACKFENNapvGQFRTWVSDIEVKSYpdtrrsfLPRLCNHCETPSCVPVCPTGATYKREDGLVLVDS 129
Cdd:cd16374    3 VDPERCIGCRACEIACAREHS---GKPRISVEVVEDLAS-------VPVRCRHCEDAPCMEVCPTGAIYRDEDGAVLVDP 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 749460529 130 DKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLND 190
Cdd:cd16374   73 DKCIGCGMCAMACPFGVPRFDPSLKVAVKCDLCIDRRREGKLPACVEACPTGALKFGDIEE 133
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 48-186 6.47e-40

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 135.61  E-value: 6.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNAP--VGQFR---------TWVSDIEVKSY----PDTRRSFL--PRLCNHCETPSCVP 110
Cdd:cd16366    1 FLVDTSRCTGCRACQVACKQWNGLPaeKTEFTgsyqnppdlTAHTWTLVRFYevekPGGDLSWLfrKDQCMHCTDAGCLA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529 111 VCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFG 186
Cdd:cd16366   81 ACPTGAIIRTETGTVVVDPETCIGCGYCVNACPFDIPRFDEETGRVAKCTLCYDRISNGLQPACVKTCPTGALTFG 156
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 48-187 1.29e-39

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 134.74  E-value: 1.29e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNAPVGQFR--------------TW--VSDIEV-KSYPDTRRSFLPRLCNHCETPSCVP 110
Cdd:cd10562    1 MLVDTSKCTACRGCQVACKQWNQLPAEKTPftgsyqnppdltpnTWtlIRFYEHeEDNGGIRWLFRKRQCMHCTDAACVK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529 111 VCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGD 187
Cdd:cd10562   81 VCPTGALYKTENGAVVVDEDKCIGCGYCVAACPFDVPRYDETTNKITKCTLCFDRIENGMQPACVKTCPTGALTFGD 157
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 95-220 9.85e-39

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 138.26  E-value: 9.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  95 FLPRLCNHCETPSCVPVCPTGATYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPA 173
Cdd:cd10557  174 YLPRICNHCLNPACVAACPSGAIYKReEDGIVLIDQDRCRGWRMCVSACPYKKVYYNWKTGKSEKCIFCYPRLEAGQPTV 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 174 CAETCVGGAR------------------------------IFGDLNDPQ--------------------SPASKLIAEND 203
Cdd:cd10557  254 CSETCVGRIRylgvllydadrileaaavvpekdlveaqldIILDPNDPEviaaakangipdnwieaaqrSPVYKMVKEWK 333

                        170
                 ....*....|....*...
gi 749460529 204 VSV-LKPSAGTKPNVFYI 220
Cdd:cd10557  334 IALpLHPEYRTLPMVFYV 351
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 47-229 9.38e-38

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 132.12  E-value: 9.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  47 GMVIDLRRCVGCQACTVACKFENNAPVGQFR---------------TW--VSDIEVKSYPDTRRS-------FLPRLCNH 102
Cdd:cd10560    1 GFFTDTSICIGCKACEVACKQWNQLPADGYDfsgmsydntgdlsasTWrhVKFIERPTEDGPANEggdlqwlFMSDVCKH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 103 CETPSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGA 182
Cdd:cd10560   81 CTDAGCLEACPTGAIFRTEFGTVYIQPDICNGCGYCVAACPFGVIDRNEETGRAHKCTLCYDRLKDGLEPACAKACPTGS 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529 183 RIFGDLND----PQSPASKLIAENDVSVLKPSAGTKP-----NVFYIGLNHPEIAN 229
Cdd:cd10560  161 IQFGPLEElrerARARVEQLHEQGVVEAYLYGADPTEgygglNAFFLLLDKPEVYG 216
NarY COG1140
Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and ...
 95-220 4.65e-37

Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440755 [Multi-domain]  Cd Length: 485  Bit Score: 136.09  E-value: 4.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  95 FLPRLCNHCETPSCVPVCPTGATYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPA 173
Cdd:COG1140  177 YLPRICEHCLNPACVASCPSGAIYKReEDGIVLVDQDKCRGWRMCVSGCPYKKVYFNWKTGKAEKCIFCYPRIEAGQPTV 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 174 CAETCVGGAR------------------------------IFGDLNDP--------------------QSPASKLIAEND 203
Cdd:COG1140  257 CSETCVGRIRylgvllydadrveeaasvpdeqdlyeaqldVFLDPHDPeviaaarkdgipddwieaaqRSPVYKLAKEWK 336

                        170
                 ....*....|....*...
gi 749460529 204 VSV-LKPSAGTKPNVFYI 220
Cdd:COG1140  337 VALpLHPEYRTLPMVWYV 354
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 95-188 6.31e-36

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 123.13  E-value: 6.31e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529   95 FLPRLCNHCETPSCVPVCPTGATYKR-EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPA 173
Cdd:pfam13247   5 FFPEQCRHCLNPPCKASCPVGAIYKDeETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYDRVEAGLLPA 84

                          90
                  ....*....|....*
gi 749460529  174 CAETCVGGARIFGDL 188
Cdd:pfam13247  85 CVQTCPTGAMNFGDR 99
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 50-218 1.88e-32

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 117.87  E-value: 1.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  50 IDLRRCVGCQACTVACK--FENNAPVGQFR------------TWVSdIEVKSYPDTRR---SFLPRLCNHCETPSCVPVC 112
Cdd:cd10558    4 IDVSKCIGCKACQVACKewNDLRAEVGHNVgtyqnpadlspeTWTL-MKFREVEDNGKlewLIRKDGCMHCADPGCLKAC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 113 PT-GATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDP 191
Cdd:cd10558   83 PSpGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMYKCTLCSDRVSVGLEPACVKTCPTGALHFGTKEDM 162

                        170       180
                 ....*....|....*....|....*..
gi 749460529 192 QSPASKLIAEndvsvLKPSAGTKPNVF 218
Cdd:cd10558  163 LALAEKRVAA-----LKERGYTNAGLY 184
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 48-182 3.51e-32

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 114.60  E-value: 3.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNapvGQFRTWVSDIEVKSYPDTRRSFlPRLCNHCETPSCVPVCPTGATYK-REDGLVL 126
Cdd:cd10550    1 LVVDPEKCTGCRTCELACSLKHE---GVFNPSLSRIRVVRFEPEGLDV-PVVCRQCEDAPCVEACPVGAISRdEETGAVV 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529 127 VDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCahrleeGLLPACAETCVGGA 182
Cdd:cd10550   77 VDEDKCIGCGMCVEACPFGAIRVDPETGKAIKCDLC------GGDPACVKVCPTGA 126
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 50-186 4.39e-30

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 109.65  E-value: 4.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  50 IDLRRCVGCQACTVACKFENNAPVGQFRTWVSDIEVKS----YPDTRRSFlPRLCNHCETPSCVPVCPTGATYK-REDGL 124
Cdd:cd10563    4 IDEEKCLGCKLCEVACAVAHSKSKDLIKAKLEKERPRPrirvEESGGRSF-PLQCRHCDEPPCVKACMSGAMHKdPETGI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749460529 125 VLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEegllPACAETCVGGARIFG 186
Cdd:cd10563   83 VIHDEEKCVGCWMCVMVCPYGAIRPDKERKVALKCDLCPDRET----PACVEACPTGALVLE 140
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
47-202 4.55e-30

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 114.77  E-value: 4.55e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  47 GMVIDLRRCVGCQACTVACKFENNAPVGQF--RTWVS------------------DIEVKSYPDTRRSFLPRLCNHCETP 106
Cdd:PRK10882  39 GMLYDSTLCVGCQACVTKCQEINFPERNPQgeQTWDNpdklspytnniikvwksgTGVNKDQEENGYAYIKKQCMHCVDP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 107 SCVPVCPTGATYKR-EDGLVLVDSDKCWGCGSCVTACPYGA---RFINAETKIAdKCTFCAH----RLEEGLLPACAETC 178
Cdd:PRK10882 119 NCVSVCPVSALTKDpKTGIVHYDKDVCTGCRYCMVACPFNVpkyDYNNPFGAIH-KCELCNQkgveRLDKGGLPGCVEVC 197

                        170       180
                 ....*....|....*....|....
gi 749460529 179 VGGARIFGDLNDPQSPASKLIAEN 202
Cdd:PRK10882 198 PTGAVIFGTREELLAEAKRRLALK 221
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 48-193 9.10e-29

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 107.09  E-value: 9.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKfENNAPVGQFRTWVSDIEvksyPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVL- 126
Cdd:cd16369    4 FFIDPSRCIGCRACVAACR-ECGTHRGKSMIHVDYID----RGESTQTAPTVCMHCEDPTCAEVCPADAIKVTEDGVVQs 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529 127 VDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETCVGGARIFGDLNDPQS 193
Cdd:cd16369   79 ALKPRCIGCSNCVNACPFGVPKYDEERNLMMKCDMCYDRTSVGKAPMCASVCPSGALFYGTREEIQA 145
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
49-178 2.53e-27

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 102.43  E-value: 2.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  49 VIDLRRCVGCQACTVACKFENNAPVGqfRTWVSDIEVKsypDTRRSFLPRLCNHCETPSCVPVCPTGATYkREDGLVLVD 128
Cdd:COG1142    6 IADPEKCIGCRTCEAACAVAHEGEEG--EPFLPRIRVV---RKAGVSAPVQCRHCEDAPCAEVCPVGAIT-RDDGAVVVD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 749460529 129 SDKCWGCGSCVTACPYGARFINAET--KIADKCTFCAHRLEeglLPACAETC 178
Cdd:COG1142   80 EEKCIGCGLCVLACPFGAITMVGEKsrAVAVKCDLCGGREG---GPACVEAC 128
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 49-178 1.00e-24

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 95.79  E-value: 1.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  49 VIDLRRCVGCQACTVACKfennapvgqfrTWVSDIEVKSYPDTRRSFLPRL-------------CNHCETPSCVPVCPTG 115
Cdd:cd10554    3 IADPDKCIGCRTCEVACA-----------AAHSGKGIFEAGTDGLPFLPRLrvvktgevtapvqCRQCEDAPCANVCPVG 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749460529 116 ATYkREDGLVLVDSDKCWGCGSCVTACPYGA-----------RFINAETKIADKCTFCAHRlEEGllPACAETC 178
Cdd:cd10554   72 AIS-QEDGVVQVDEERCIGCKLCVLACPFGAiemapttvpgvDWERGPRAVAVKCDLCAGR-EGG--PACVEAC 141
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 47-186 2.26e-23

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 93.64  E-value: 2.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  47 GMVIDLRRCVGCQ-----ACTVACKFENNA----PVGQ----------FRTW-----------------VSDIEVKSYPD 90
Cdd:cd16368    2 ATLIDLTKCDGCPgesipACVRACREKNQArfpePVSKpiqpywprkrIEDWsdkrdvtdrltpynwlyVQKLTVDTAGG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  91 TRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYG--AR------FINAETKIAD----- 157
Cdd:cd16368   82 EKEVFIPRRCMHCDNPPCAKLCPFGAARKTPEGAVYIDDDLCFGGAKCRDVCPWHipQRqagvgiYLHLAPEYAGggvmy 161

                        170       180
                 ....*....|....*....|....*....
gi 749460529 158 KCTFCAHRLEEGLLPACAETCVGGARIFG 186
Cdd:cd16368  162 KCDLCKDLLAQGKPPACIEACPKGAQYFG 190
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 49-178 3.07e-23

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 91.57  E-value: 3.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  49 VIDLRRCVGCQACTVACKFENNapvGQFRTWVSDIEVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATYKREDGLVLVD 128
Cdd:cd16370    5 VKDMERCIGCYSCMLACSRRVH---KSASLSKSAIRVRTRGGLEGGFTVVVCRACEDPPCAEACPTGALEPRKGGGVVLD 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 749460529 129 SDKCWGCGSCVTACPYGARFINAETKIADKCTFCAhrleegllpACAETC 178
Cdd:cd16370   82 KEKCIGCGNCVKACIVGAIFWDEETNKPIICIHCG---------YCARYC 122
PRK09898 PRK09898
ferredoxin-like protein;
54-182 4.96e-23

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 92.98  E-value: 4.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  54 RCVGCQACTVACKFENNAPVGQF--RTWVS------DIEVKS----YPDTrrSFLPRLCNHCETPSCVPVCPTGA-TYKR 120
Cdd:PRK09898  67 RCTGCHRCEISCTNFNDGSVGTFfsRIKIHrnyffgDNGVGSggglYGDL--NYTADTCRQCKEPQCMNVCPIGAiTWQQ 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749460529 121 EDGLVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAhrleegllpACAETCVGGA 182
Cdd:PRK09898 145 KEGCITVDHKRCIGCSACTTACPWMMATVNTESKKSSKCVLCG---------ECANACPTGA 197
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 51-178 1.00e-22

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 96.74  E-value: 1.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  51 DLRRCVGCQACTVACKFENNApvGQfrtwvsdievksYPDTRRSFLPRL-------------CNHCETPSCVPVCPTGAT 117
Cdd:PRK12769   8 NSQQCLGCHACEIACVMAHND--EQ------------HVLSQHHFHPRItvikhqqqrsavtCHHCEDAPCARSCPNGAI 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 749460529 118 YKREDGlVLVDSDKCWGCGSCVTACPYGARFI-------NAETKIADKCTFCAHRlEEGllPACAETC 178
Cdd:PRK12769  74 SHVDDS-IQVNQQKCIGCKSCVVACPFGTMQIvltpvaaGKVKATAHKCDLCAGR-ENG--PACVENC 137
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 47-201 1.69e-20

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 86.33  E-value: 1.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  47 GMVIDLRRCVGCQACTVACKFENNAPVGQFRTWVS-----DIEVKSYPDTRRS------------FLPRLCNHCETPSCV 109
Cdd:cd10559    1 SFLIDTTRCTACRGCQVACKQWNQLPAEQTKNTGShqnppDLSANTYKLVRFNevrnengkpdwlFFPDQCRHCVTPPCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 110 PVCP-----------TGATYKREDGLVLVDSDkcwgcgsCVTACPYGARFINAETKIADKCTFCAHRLEEGLLPACAETC 178
Cdd:cd10559   81 DAADmvpgaviqdeaTGAVVFTEKTAELDFDD-------VLSACPYNIPRKNEATGRIVKCDMCIDRVSNGLQPACVKAC 153

                        170       180
                 ....*....|....*....|...
gi 749460529 179 VGGARIFGDLNDPQSPASKLIAE 201
Cdd:cd10559  154 PTGAMNFGDRDEMLAMASKRLEE 176
PRK10330 PRK10330
electron transport protein HydN;
48-189 2.72e-18

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 79.93  E-value: 2.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKfennapvgqfrtwVSDIEVKSYPD-TRRSFLPR-------------LCNHCETPSCVPVCP 113
Cdd:PRK10330   5 IIADASKCIGCRTCEVACV-------------VSHQENQDCASlTPETFLPRihvikgvnvstatVCRQCEDAPCANVCP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 114 TGATyKREDGLVLVDSDKCWGCGSCVTACPYGARFI---------------NAETKIADKCTFCAHRlEEGllPACAETC 178
Cdd:PRK10330  72 NGAI-SRDKGFVHVMQERCIGCKTCVVACPYGAMEVvvrpvirnsgaglnvRAEKAEANKCDLCNHR-EDG--PACMAAC 147

                        170
                 ....*....|.
gi 749460529 179 VGGARIFGDLN 189
Cdd:PRK10330 148 PTHALICVDRN 158
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 48-184 1.80e-17

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 76.58  E-value: 1.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVAC--KFENNAPVGQFRTWVSDIEVksypdtrrsflPRLCNHCETPSCVPVCPTGATYKREDGLV 125
Cdd:cd16367   14 LVIDLDRCIRCDNCEKACadTHDGHSRLDRNGLRFGNLLV-----------PTACRHCVDPVCMIGCPTGAIHRDDGGEV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 749460529 126 LVDsDKCWGCGSCVTACPYGArfinAETKIADKCTFCAHRLEegllPACAETCVGGARI 184
Cdd:cd16367   83 VIS-DACCGCGNCASACPYGA----IQMVRAVKCDLCAGYAG----PACVSACPTGAAI 132
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 48-178 2.27e-17

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 81.23  E-value: 2.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  48 MVIDLRRCVGCQACTVACKFENNApvgqfrtwvsdievKSYPDTRRSFLPRL-------------CNHCETPSCVPVCPT 114
Cdd:PRK12809   5 IAAEAAECIGCHACEIACAVAHNQ--------------ENWPLSHSDFRPRIhvvgkgqaanpvaCHHCNNAPCVTACPV 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749460529 115 GATYKREDGlVLVDSDKCWGCGSCVTACPYGArfINAETKIADKCTFCAHRleEGLLPACAETC 178
Cdd:PRK12809  71 NALTFQSDS-VQLDEQKCIGCKRCAIACPFGV--VEMVDTIAQKCDLCNQR--SSGTQACIEVC 129
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 49-182 9.47e-15

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 68.90  E-value: 9.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  49 VIDLRRCVGCQACTVACKFennapvgqfrTW--VSDIEvKS---YPDTRRSFLPRLCNHCETpsCVPVCPTGATYKREDG 123
Cdd:cd16372    4 VTDPEKCIGCLQCEEACSK----------TFfkEEDRE-KScirITETEGGYAINVCNQCGE--CIDVCPTGAITRDANG 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 749460529 124 LVLVDSDKCWGCGSCVTACPYGARFINAETKIADKCTFCAhrleegllpACAETCVGGA 182
Cdd:cd16372   71 VVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEPFKCIACG---------ICVKACPTGA 120
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 32-146 2.03e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 59.72  E-value: 2.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  32 PKNSLKQQSGSGKRWGMVIDLRRCVGCQACTVACkfennaPVGQFRtwvSDIEVKSYPDTRRSFLP--RLCNHCETpsCV 109
Cdd:cd10549   19 PTDAIELGPNGAIARGPEIDEDKCVFCGACVEVC------PTGAIE---LTPEGKEYVPKEKEAEIdeEKCIGCGL--CV 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 749460529 110 PVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:cd10549   88 KVCPVDAITLEDELEIVIDKEKCIGCGICAEVCPVNA 124
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
97-156 4.82e-11

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 57.43  E-value: 4.82e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  97 PRLCNHCETpsCVPVCPTGATYKREDGLVlVDSDKCWGCGSCVTACPYGARFINAETKIA 156
Cdd:COG2768   10 EEKCIGCGA--CVKVCPVGAISIEDGKAV-IDPEKCIGCGACIEVCPVGAIKIEWEEDEE 66
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 97-146 2.78e-10

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 55.12  E-value: 2.78e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 749460529  97 PRLCNHCETpsCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG1149   10 EEKCIGCGL--CVEVCPEGAIKLDDGGAPVVDPDLCTGCGACVGVCPTGA 57
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 49-178 1.42e-09

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 54.71  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  49 VIDLRRCVGCQACTVACKFENnapvgqfrtwvsdIEVKSYPDTRR--SFLPRLCNHCEtpSCVPVCPTGA--------TY 118
Cdd:cd10549    2 KYDPEKCIGCGICVKACPTDA-------------IELGPNGAIARgpEIDEDKCVFCG--ACVEVCPTGAieltpegkEY 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 749460529 119 KREDGLVLVDSDKCWGCGSCVTACPYGARFINAETKI---ADKCTFCAhrleegllpACAETC 178
Cdd:cd10549   67 VPKEKEAEIDEEKCIGCGLCVKVCPVDAITLEDELEIvidKEKCIGCG---------ICAEVC 120
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 99-146 7.26e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 51.21  E-value: 7.26e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 749460529  99 LCNHCetPSCVPVCPTGAtYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG2221   16 KCIGC--GLCVAVCPTGA-ISLDDGKLVIDEEKCIGCGACIRVCPTGA 60
flavo_MJ0208 TIGR02700
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ...
 100-146 8.01e-09

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]


Pssm-ID: 131747 [Multi-domain]  Cd Length: 234  Bit Score: 54.49  E-value: 8.01e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 749460529  100 CNHCETpsCVPVCPTGATYKReDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:TIGR02700 150 CKGCGI--CVDACPRSAIDMV-DGKAFIRLLKCVGCGKCKEACPYNA 193
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
50-147 9.51e-09

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 55.42  E-value: 9.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  50 IDLRRCVGCQACTVACKFENNAPVGqfrtwvsDIEVKSYPDTRRSFLPRLCNhcetpSCVPVCPTGAtYKREDGLVLVDS 129
Cdd:COG4624   53 RCCLCCCCCCRCCVAISCIQVRGII-------IIDKRGPSIIRDKEKCKNCY-----PCVRACPVKA-IKVDDGKAEIDE 119

                         90
                 ....*....|....*...
gi 749460529 130 DKCWGCGSCVTACPYGAR 147
Cdd:COG4624  120 EKCISCGQCVAVCPFGAI 137
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
97-146 1.32e-08

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 54.87  E-value: 1.32e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 749460529  97 PRLCNHCETpsCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG1148  495 PEKCTGCGR--CVEVCPYGAISIDEKGVAEVNPALCKGCGTCAAACPSGA 542
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 97-146 2.68e-08

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 49.66  E-value: 2.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 749460529  97 PRLCNHCEtpSCVPVCPTGAtYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG4231   21 EDKCTGCG--ACVKVCPADA-IEEGDGKAVIDPDLCIGCGSCVQVCPVDA 67
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 91-146 3.33e-08

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 49.67  E-value: 3.33e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  91 TRRSFLPRL----CNHCEtpSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG1144   19 GWRVERPVVdedkCIGCG--LCWIVCPDGAIRVDDGKYYGIDYDYCKGCGICAEVCPVKA 76
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 107-143 9.73e-08

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 51.53  E-value: 9.73e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 749460529 107 SCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACP 143
Cdd:COG2878  144 DCIKACPFDAIVGAAKGMHTVDEDKCTGCGLCVEACP 180
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 99-146 1.10e-07

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 47.78  E-value: 1.10e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 749460529  99 LCNHCEtpSCVPVCPTGATYKREDGL--VLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG1146    9 KCIGCG--ACVEVCPVDVLELDEEGKkaLVINPEECIGCGACELVCPVGA 56
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 100-146 1.72e-07

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 46.75  E-value: 1.72e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 749460529  100 CNHCETpsCVPVCPTGATYKREDGL------VLVDSDKCWGCGSCVTACPYGA 146
Cdd:pfam12838   1 CIGCGA--CVAACPVGAITLDEVGEkkgtktVVIDPERCVGCGACVAVCPTGA 51
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 52-162 2.14e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 49.18  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  52 LRRCVGCQACTVACkfennaPVG--QFRTWVSDIEVKSYP--DTRRSFlprlCNHCETpSCVPVCPTGA---TYKRED-- 122
Cdd:cd16373   13 LALCIRCGLCVEAC------PTGviQPAGLEDGLEGGRTPylDPREGP----CDLCCD-ACVEVCPTGAlrpLDLEEQkv 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 749460529 123 --GLVLVDSDKCW------GCGSCVTACPYGARFINAETK------IADKCTFC 162
Cdd:cd16373   82 kmGVAVIDKDRCLawqggtDCGVCVEACPTEAIAIVLEDDvlrpvvDEDKCVGC 135
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
93-154 2.39e-07

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 48.02  E-value: 2.39e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529  93 RSFLPRL----CNHCETpsCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETK 154
Cdd:PRK09623  42 RTFMPVVdeskCVKCYI--CWKFCPEPAIYIKEDGYVAIDYDYCKGCGICANECPTKAITMVKEEK 105
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
107-145 4.43e-07

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 49.93  E-value: 4.43e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 749460529 107 SCVPVCPTGATYKrEDGLVLVDSDKCWGCGSCVTACPYG 145
Cdd:PRK07118 146 SCVAACPFDAIHI-ENGLPVVDEDKCTGCGACVKACPRN 183
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 100-146 5.74e-07

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 45.89  E-value: 5.74e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 749460529 100 CNHCETpsCVPVCPTGA---TYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG1143    4 CIGCGL--CVRVCPVDAitiEDGEPGKVYVIDPDKCIGCGLCVEVCPTGA 51
NapF COG1145
Ferredoxin [Energy production and conversion];
100-146 8.56e-07

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 48.95  E-value: 8.56e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 749460529 100 CNHCEtpSCVPVCPTGA-TYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:COG1145  184 CIGCG--LCVKVCPTGAiRLKDGKPQIVVDPDKCIGCGACVKVCPVGA 229
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
127-192 2.36e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 48.32  E-value: 2.36e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749460529 127 VDSDKCWGCGSCVTACPYGARFINAETK---IADKCTFCAhrleegllpACAETCVGGARIFGDLNDPQ 192
Cdd:COG1148  493 VDPEKCTGCGRCVEVCPYGAISIDEKGVaevNPALCKGCG---------TCAAACPSGAISLKGFTDDQ 552
methan_mark_16 TIGR03287
putative methanogenesis marker 16 metalloprotein; Members of this protein family, to date, are ...
 77-150 4.51e-06

putative methanogenesis marker 16 metalloprotein; Members of this protein family, to date, are found in a completed prokaryotic genome if and only if the species is one of the archaeal methanogens. The exact function is unknown, but likely is linked to methanogenesis or a process closely connected to it. This protein is a predicted to bind FeS clusters, based on the presence of two copies of the Fer4 domain (pfam00037), with each copy having four Cys residues invariant across all members. [Energy metabolism, Methanogenesis]


Pssm-ID: 274501 [Multi-domain]  Cd Length: 391  Bit Score: 47.07  E-value: 4.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529   77 RTWVSDI---EVKSYPDTRRSFLPRLCNHCETPSCVPVCPTGATykREDGLVlvDSDKCWGCGSCVTACPYGARFIN 150
Cdd:TIGR03287 278 RTPIAEItyaDVWDNTDVRPKYNPERCENCDPCLVEEACPVPAI--KKDGTL--NTEDCFGCGYCAEICPGGAFEVN 350
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
49-146 5.04e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 46.46  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  49 VIDLRRCVGCQACTVACKfeNN----APVGQfRTWVSDIEVKSYPDTRRSflprlcnhCET-----PSCVPVCPTGATyK 119
Cdd:PRK07118 164 VVDEDKCTGCGACVKACP--RNvielIPKSA-RVFVACNSKDKGKAVKKV--------CEVgcigcGKCVKACPAGAI-T 231

                         90       100
                 ....*....|....*....|....*..
gi 749460529 120 REDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:PRK07118 232 MENNLAVIDQEKCTSCGKCVEKCPTKA 258
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 108-143 9.84e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 44.55  E-value: 9.84e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 749460529 108 CVPVCPTGATYKREDGLVL---VDSDKCWGCGSCVTACP 143
Cdd:cd16373  105 CVEACPTEAIAIVLEDDVLrpvVDEDKCVGCGLCEYVCP 143
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
59-146 1.32e-05

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 45.44  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  59 QACTVACkfennaPVGQFRTWVSD---IEVKSYPDTrrsflprlCNHCEtpSCVPVCPTGAtykrEDGLVLVDSDKCWGC 135
Cdd:COG0348  182 QWCRYLC------PYGAFQGLLSDlstLRVRYDRGD--------CIDCG--LCVKVCPMGI----DIRKGEINQSECINC 241

                         90
                 ....*....|.
gi 749460529 136 GSCVTACPYGA 146
Cdd:COG0348  242 GRCIDACPKDA 252
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
120-192 1.54e-05

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 42.03  E-value: 1.54e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529 120 REDGLVLVDSDKCWGCGSCVTACPYGArfINAETKIA----DKCTFCahrleegllPACAETCVGGARIFGDLNDPQ 192
Cdd:COG2768    1 HSLGKPYVDEEKCIGCGACVKVCPVGA--ISIEDGKAvidpEKCIGC---------GACIEVCPVGAIKIEWEEDEE 66
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
108-178 2.43e-05

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 44.28  E-value: 2.43e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749460529 108 CVPVCPTGATY---KREDGLVL-VDSDKCWGCGSCVTACPYGArFINAETKIADKCTFCAhrleegllpACAETC 178
Cdd:COG0348  184 CRYLCPYGAFQgllSDLSTLRVrYDRGDCIDCGLCVKVCPMGI-DIRKGEINQSECINCG---------RCIDAC 248
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 93-154 3.48e-05

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 41.94  E-value: 3.48e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529  93 RSFLPRL----CNHCETpsCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETK 154
Cdd:PRK09624  42 RVFMPEFnrdkCVRCYL--CYIYCPEPAIYLDEEGYPVFDYDYCKGCGICANECPTKAIEMVRETK 105
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
32-128 3.64e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 42.34  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  32 PKNSLKQQSGSgkrwgMVIDLRRCVGCQACTVACKFENnapvgqfrtwvsdIEVKSYPDTRRSFLPRLCNHCET-PSCVP 110
Cdd:COG1142   65 PVGAITRDDGA-----VVVDEEKCIGCGLCVLACPFGA-------------ITMVGEKSRAVAVKCDLCGGREGgPACVE 126

                         90
                 ....*....|....*...
gi 749460529 111 VCPTGAtykredgLVLVD 128
Cdd:COG1142  127 ACPTGA-------LRLVD 137
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 127-182 3.70e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 40.80  E-value: 3.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 749460529 127 VDSDKCWGCGSCVTACPYGA-RFINAETKI-ADKCTFCAHrleegllpaCAETCVGGA 182
Cdd:COG2221   12 IDEEKCIGCGLCVAVCPTGAiSLDDGKLVIdEEKCIGCGA---------CIRVCPTGA 60
napG PRK09476
quinol dehydrogenase periplasmic component; Provisional
 52-143 3.96e-05

quinol dehydrogenase periplasmic component; Provisional


Pssm-ID: 236534 [Multi-domain]  Cd Length: 254  Bit Score: 43.85  E-value: 3.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  52 LRRCVGCQACTVACKFEnnapVGQFRTWVSDIEVKS-YpdtrrsFLPR--LCNHCETPSCVPVCPTGA-TYKRED----- 122
Cdd:PRK09476  58 LSACIRCGLCVQACPYD----TLKLATLASGLSAGTpY------FVARdiPCEMCEDIPCVKACPSGAlDRELVDiddar 127

                         90       100
                 ....*....|....*....|....*...
gi 749460529 123 -GL-VLVDSDKC---WG--CGSCVTACP 143
Cdd:PRK09476 128 mGLaVLVDQENClnfQGlrCDVCYRVCP 155
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 97-165 4.18e-05

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 44.39  E-value: 4.18e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529  97 PRLCNHcetpSCVPVCP---TG--ATYKRE-DGLVLVDSDKCWGCGSCVTACPYGA-RFINAETKIADKCTfcaHR 165
Cdd:COG1245   14 PKKCNY----ECIKYCPvnrTGkeAIEIDEdDGKPVISEELCIGCGICVKKCPFDAiSIVNLPEELEEDPV---HR 82
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
98-178 7.64e-05

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 43.48  E-value: 7.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  98 RLCNHCETPSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA-RFINAETKIA-DKCTFCAHrleegllpaCA 175
Cdd:COG4624   59 CCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAiKVDDGKAEIDeEKCISCGQ---------CV 129


                 ...
gi 749460529 176 ETC 178
Cdd:COG4624  130 AVC 132
Fer4_9 pfam13187
4Fe-4S dicluster domain;
107-146 8.33e-05

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 39.46  E-value: 8.33e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 749460529  107 SCVPVCPTGATYKREDGLVLV---DSDKCWGCGSCVTACPYGA 146
Cdd:pfam13187   7 ACVAACPAGAIVPDLVGQTIRgdiAGLACIGCGACVDACPRGA 49
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
97-165 9.94e-05

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 43.26  E-value: 9.94e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749460529  97 PRLCNHcetpSCVPVCP---TGA---TYKREDGLVLVDSDKCWGCGSCVTACPYGA-RFINAETKIADKCTfcaHR 165
Cdd:PRK13409  14 PKKCNY----ECIKYCPvvrTGEetiEIDEDDGKPVISEELCIGCGICVKKCPFDAiSIVNLPEELEEEPV---HR 82
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 99-143 1.05e-04

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 41.27  E-value: 1.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 749460529  99 LCNHCEtpSCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACP 143
Cdd:PRK09625  60 ICINCF--NCWVYCPDAAILSRDKKLKGVDYSHCKGCGVCVEVCP 102
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 100-146 2.05e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 42.17  E-value: 2.05e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 749460529 100 CNHC-ETPSCVPVCPTGATYKREDGL-VLVDSDKCWGCGSCVTACPYGA 146
Cdd:PRK12771 509 CGNCfECDNCYGACPQDAIIKLGPGRrYHFDYDKCTGCHICADVCPCGA 557
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 125-182 2.19e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 38.54  E-value: 2.19e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 749460529 125 VLVDSDKCWGCGSCVTACPYGARFINAETKIA-----DKCTFCAhrleegllpACAETCVGGA 182
Cdd:COG1146    3 PVIDTDKCIGCGACVEVCPVDVLELDEEGKKAlvinpEECIGCG---------ACELVCPVGA 56
PRK13795 PRK13795
hypothetical protein; Provisional
 108-150 2.29e-04

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 42.29  E-value: 2.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 749460529 108 CVPVCPTGATYKREDG-LVLVDSDKCWGCGSCVTACPYgARFIN 150
Cdd:PRK13795 589 CVGACPTGAIRIEEGKrKISVDEEKCIHCGKCTEVCPV-VKYKD 631
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 127-182 2.38e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.56  E-value: 2.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 749460529 127 VDSDKCWGCGSCVTACPYGA-RFINAETKI--ADKCTFCAhrleegllpACAETCVGGA 182
Cdd:COG1149    8 IDEEKCIGCGLCVEVCPEGAiKLDDGGAPVvdPDLCTGCG---------ACVGVCPTGA 57
PRK13795 PRK13795
hypothetical protein; Provisional
 116-189 2.60e-04

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 41.90  E-value: 2.60e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 749460529 116 ATYKREDGLVLVDSDKCWGCGSCVTACPYGARFINAETK----IADKCTFCAhrleegllpACAETCVgGARIFGDLN 189
Cdd:PRK13795 567 ASLFKDAARLLRRAAECVGCGVCVGACPTGAIRIEEGKRkisvDEEKCIHCG---------KCTEVCP-VVKYKDKRN 634
NapF COG1145
Ferredoxin [Energy production and conversion];
119-178 2.96e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 41.25  E-value: 2.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749460529 119 KREDGLVLVDSDKCWGCGSCVTACPYGA-RFINAETKI---ADKCTFCahrleegllPACAETC 178
Cdd:COG1145  171 AIKKAKAVIDAEKCIGCGLCVKVCPTGAiRLKDGKPQIvvdPDKCIGC---------GACVKVC 225
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 128-178 3.19e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 41.13  E-value: 3.19e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 749460529 128 DSDKCWGCGSCVTACPYGARFINAE---TKIADKCTFCAhrleegllpACAETC 178
Cdd:COG2878  135 CEYGCIGCGDCIKACPFDAIVGAAKgmhTVDEDKCTGCG---------LCVEAC 179
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 125-146 3.52e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 36.84  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|..
gi 749460529  125 VLVDSDKCWGCGSCVTACPYGA 146
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGA 22
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 106-182 7.46e-04

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 38.28  E-value: 7.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529 106 PSCVPVcPTGATYKredGLVLVDSDKCWGCGSCVTACPYGA-RFINAETKIA---DKCTFCAHrleegllpaCAETCVGG 181
Cdd:PRK08348  22 PATEPV-PVPEDFR---GKILYDVDKCVGCRMCVTVCPAGVfVYLPEIRKVAlwtGRCVFCGQ---------CVDVCPTG 88


                 .
gi 749460529 182 A 182
Cdd:PRK08348  89 A 89
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 32-116 9.59e-04

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 38.78  E-value: 9.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749460529  32 PKNSLKQQSGSgkrwgMVIDLRRCVGCQACTVACkfennaPVGQfrtwvsdIEVKSYPDTRRSFLPRL------CNHC-- 103
Cdd:cd10554   69 PVGAISQEDGV-----VQVDEERCIGCKLCVLAC------PFGA-------IEMAPTTVPGVDWERGPravavkCDLCag 130

                         90
                 ....*....|....*
gi 749460529 104 --ETPSCVPVCPTGA 116
Cdd:cd10554  131 reGGPACVEACPTKA 145
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 97-143 1.10e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 36.46  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 749460529   97 PRLCNHCETpsCVPVCPT-----GATYKREDGL-VLVDSDKCWGCGSCVTACP 143
Cdd:pfam13237   6 PDKCIGCGR--CTAACPAgltrvGAIVERLEGEaVRIGVWKCIGCGACVEACP 56
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 130-182 2.27e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 35.88  E-value: 2.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 749460529 130 DKCWGCGSCVTACPYGARFINAETKI------ADKCTFCAhrleegllpACAETCVGGA 182
Cdd:COG1143    2 DKCIGCGLCVRVCPVDAITIEDGEPGkvyvidPDKCIGCG---------LCVEVCPTGA 51
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 99-146 3.58e-03

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 37.75  E-value: 3.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 749460529  99 LCNHCetPSCVPVCPTGATYKREDGLvLVDSDKCWGCGSCVTACPYGA 146
Cdd:cd03110   65 KCIRC--GNCERVCKFGAILEFFQKL-IVDESLCEGCGACVIICPRGA 109
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 100-142 4.35e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 36.22  E-value: 4.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 749460529  100 CNHCEtpSCVPVCPTGATYKreDGLVLvdsdKCWGCGSCVTAC 142
Cdd:pfam13746  61 CIDCE--SCVQVCPTGIDIR--KGLQL----ECINCGLCIDAC 95
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 107-146 5.39e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 36.45  E-value: 5.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 749460529 107 SCVPVCPTGA-TYKREDG---LVLVDSDKCWGCGSCVTACPYGA 146
Cdd:cd10564   90 SCQDACPTQAiRFRPRLGgiaLPELDADACTGCGACVSVCPVGA 133
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 124-178 5.87e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 34.15  E-value: 5.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749460529  124 LVLVDSDKCWGCGSCVTACP---------YGARFINAETKIADKCTFCAhrleegllpACAETC 178
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPagltrvgaiVERLEGEAVRIGVWKCIGCG---------ACVEAC 55
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 100-146 6.41e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 37.17  E-value: 6.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 749460529 100 CNHCETpsCVPVCPTGATYKREDGLVLVDSDKCWGCGSCVTACPYGA 146
Cdd:PRK00783 171 CDECEK--CVEACPRGVLELKEGKLVVTDLLNCSLCKLCERACPGKA 215
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 125-178 8.07e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 34.25  E-value: 8.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 749460529 125 VLVDSDKCWGCGSCVTACPYGArFINAETKIA---DKCTFCAhrleegllpACAETC 178
Cdd:COG4231   17 YVIDEDKCTGCGACVKVCPADA-IEEGDGKAVidpDLCIGCG---------SCVQVC 63
Fer4_6 pfam12837
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 125-146 9.67e-03

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 432822 [Multi-domain]  Cd Length: 24  Bit Score: 32.97  E-value: 9.67e-03
                          10        20
                  ....*....|....*....|..
gi 749460529  125 VLVDSDKCWGCGSCVTACPYGA 146
Cdd:pfam12837   2 VEVDPDKCIGCGRCVVVCPYGA 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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