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Conserved domains on  [gi|1450693885|dbj|GBU73486|]
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transcriptional regulator [Staphylococcus aureus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-135 5.71e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.12  E-value: 5.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885   1 MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKD 80
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1450693885  81 YVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF--NISEREASDIVNNLR 135
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELlaGLSEEELEALLRLLR 137
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-135 5.71e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.12  E-value: 5.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885   1 MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKD 80
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1450693885  81 YVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF--NISEREASDIVNNLR 135
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELlaGLSEEELEALLRLLR 137
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
29-126 2.08e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 82.64  E-value: 2.08e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885   29 NYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSP 108
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|
gi 1450693885  109 LAEISVKVFNEF--NISERE 126
Cdd:smart00347  81 LLEARSETLAELlaGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-92 2.56e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 52.93  E-value: 2.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1450693885  36 LTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDER 92
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
15-105 1.19e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 39.88  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885  15 LFYVSSKEIIKKYTNYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNL 94
Cdd:PRK11512   17 LIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGV 96

                          90
                  ....*....|.
gi 1450693885  95 QISLTEQGKAI 105
Cdd:PRK11512   97 LVKLTTSGAAI 107
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 14-113 3.56e-03

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 34.92  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885  14 FLFYVSSKEIIKKYtnylkdYDLTYTGYIVLMAI----ENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEK 89
Cdd:TIGR01889   7 YLYIKSLKRYLKKE------FNLSLEELLILYYLgkleNNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*
gi 1450693885  90 DERNLQISLT-EQGKAIKSPLAEIS 113
Cdd:TIGR01889  81 DERKVIISINkEQRSKIESLISEIE 105
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-135 5.71e-27

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 98.12  E-value: 5.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885   1 MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKD 80
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1450693885  81 YVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEF--NISEREASDIVNNLR 135
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELlaGLSEEELEALLRLLR 137
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
29-126 2.08e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 82.64  E-value: 2.08e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885   29 NYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSP 108
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|
gi 1450693885  109 LAEISVKVFNEF--NISERE 126
Cdd:smart00347  81 LLEARSETLAELlaGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-92 2.56e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 52.93  E-value: 2.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1450693885  36 LTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDER 92
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-92 6.81e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.82  E-value: 6.81e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1450693885  34 YDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDER 92
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
15-105 1.19e-04

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 39.88  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885  15 LFYVSSKEIIKKYTNYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNL 94
Cdd:PRK11512   17 LIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGV 96

                          90
                  ....*....|.
gi 1450693885  95 QISLTEQGKAI 105
Cdd:PRK11512   97 LVKLTTSGAAI 107
HTH_27 pfam13463
Winged helix DNA-binding domain;
50-102 1.58e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 35.34  E-value: 1.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1450693885  50 DEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQG 102
Cdd:pfam13463  16 GDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 14-113 3.56e-03

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 34.92  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885  14 FLFYVSSKEIIKKYtnylkdYDLTYTGYIVLMAI----ENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEK 89
Cdd:TIGR01889   7 YLYIKSLKRYLKKE------FNLSLEELLILYYLgkleNNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*
gi 1450693885  90 DERNLQISLT-EQGKAIKSPLAEIS 113
Cdd:TIGR01889  81 DERKVIISINkEQRSKIESLISEIE 105
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
21-105 3.74e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 35.79  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450693885  21 KEIIKKYTNYLKDYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTE 100
Cdd:PRK13777   28 KSVEKDWQQWIKPYDLNINEHHILWIAYHLKGASISEIAKFGVMHVSTAFNFSKKLEERGYLTFSKKEDDKRNTYIELTE 107


                  ....*
gi 1450693885 101 QGKAI 105
Cdd:PRK13777  108 KGEEL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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