|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
20-429 |
1.56e-165 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 471.46 E-value: 1.56e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 20 VVATGIGNAMEWFDFGVYAYTTAYIGANFFsPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIIL 99
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFF-PGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 100 MAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAV 179
Cdd:cd17366 80 MAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 180 LTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRkleespvfendvatqperdninflqiirfyykDIFVCFVAVVFFNV 259
Cdd:cd17366 160 LTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRR--------------------------------PLLICIGLVLVFNV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 260 TNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVV 339
Cdd:cd17366 208 TNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 340 IVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGF 419
Cdd:cd17366 288 IFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYYLMVAAVVGL 367
|
410
....*....|
gi 1450743514 420 LVITFLHLST 429
Cdd:cd17366 368 VAVLFLTETA 377
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
6-453 |
3.89e-113 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 342.08 E-value: 3.89e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 6 ENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFsPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGD 85
Cdd:PRK10642 4 RDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFF-PGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 86 KYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIG 165
Cdd:PRK10642 83 KYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 166 TLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDN--------INFL 237
Cdd:PRK10642 163 SIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDReglqdgpkVSFK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 238 QIIRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIG 317
Cdd:PRK10642 243 EIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 318 TGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIfGGTTPLVATWL 397
Cdd:PRK10642 323 SVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWL 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 398 VTKTGDPLAPAYYLTAISVIGFLVITFLHlSTAGKSLKGSYPNV-DNEQDRAYYAEH 453
Cdd:PRK10642 402 VESTQNLMMPAYYLMVVAVIGLITGVTMK-ETANRPLKGATPAAsDIQEAKEILVEH 457
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
26-419 |
1.11e-109 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 329.62 E-value: 1.11e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 26 GNAMEWFDFGVYAYTTAYIGANFFSPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTL 105
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 106 TIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVLTFFLT 185
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 186 DEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENdVATQPERDNINFLQIIRFYYKDIFVCFVAVVFFNVTNYMVT 265
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEK-AQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLIT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 266 AYLPTYLEQVIKLDATTTSVLITCV---MAIMIPLalmFGKLADKIGEKKVFLIGTGGLTLFSIIAFM-LLHSQSFVVIV 341
Cdd:TIGR00883 240 TYLPTYLTQTLGLSANSALLVLMLSlilFFITIPL---SGALSDRIGRRPVLIIFTVLAALLAVPLLMaLLDSGSFTLFF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1450743514 342 IGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGF 419
Cdd:TIGR00883 317 FLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
17-424 |
1.43e-109 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 329.87 E-value: 1.43e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 17 KKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTST 96
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 97 IILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIM 176
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 177 IAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFEnDVATQPERDNINFLQIIRFYYKDIFVCFVAVVF 256
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFR-RAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 257 FNVTNYMVTAYLPTYLEQVIKLDATT--TSVLI-TCVMAIMIPLalmFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLH 333
Cdd:cd17369 240 ENVLFYLFTTFALSYATQTLGVDRSTvlLAVLIaSVVAAITIPL---FGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 334 SQSFVVIVIG-IFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLT 412
Cdd:cd17369 317 TGSTWLIVLAaVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLA 396
|
410
....*....|..
gi 1450743514 413 AISVIGFLVITF 424
Cdd:cd17369 397 ALAVISLVAALF 408
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
20-426 |
8.77e-88 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 274.17 E-value: 8.77e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 20 VVATGIGNAMEWFDFGVYAYTTAYIGANFFsPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIIL 99
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFF-PSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 100 MAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAV 179
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 180 LTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENdvATQPERDNINFLQIIRFYYKDIFVCFVAVVFFNV 259
Cdd:cd17367 160 LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEA--IAESNEASAGTLRELRRHPRELLLVVGLTAGGTL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 260 TNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQS--- 336
Cdd:cd17367 238 AFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDspy 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 337 --FVVIVIGIFILGFFLSTYEATMpgslPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVtKTGDPLAPAYYLTAI 414
Cdd:cd17367 318 taFALVLVGLVFLSGYTSINAVVK----AELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLK-SIGHEWVFFWYVAGL 392
|
410
....*....|..
gi 1450743514 415 SVIGFLVITFLH 426
Cdd:cd17367 393 IAISLVVYLRMP 404
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
20-420 |
7.40e-84 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 263.85 E-value: 7.40e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 20 VVATGIGNAMEWFDFGVYAYTTAYIGANFFsPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIIL 99
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFF-PSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 100 MAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAV 179
Cdd:cd17368 80 MALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 180 LTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATqPERDniNFLQIIRFYYKDIFVCFVAVVFFNV 259
Cdd:cd17368 160 LSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKAR-PTRR--ELFALLANNRRIILLGMLLVAGSTV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 260 TNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLL-HSQSFV 338
Cdd:cd17368 237 TFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLtAAPSFG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 339 VIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIG 418
Cdd:cd17368 317 RLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLG 396
|
..
gi 1450743514 419 FL 420
Cdd:cd17368 397 LL 398
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
26-425 |
2.46e-65 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 216.73 E-value: 2.46e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 26 GNAMEWFDFGVYAYTTAYIGANFFsPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTL 105
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFF-PAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 106 TIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRnslgsGLEIGTLSGYIAASIMIA-----VL 180
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRK-----GFYTSWQSASQQVAVVFAallgyLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 181 TFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDvATQPERDNInfLQIIRFYYKDIFVCFVAVVFFNVT 260
Cdd:PRK15075 177 NQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLAR-KHRPSMREI--FRSLAANWRIVLAGMLMVAMTTVS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 261 NYMVTAYLPTYLEQVIKLDATTTSVLITCVMA---IMIPlalMFGKLADKIGEKKVfLIGTGGLTLFSIIAFM--LLHSQ 335
Cdd:PRK15075 254 FYLITVYTPTFGKTVLHLSAADSLLVTLCVGVsnfIWLP---IGGALSDRIGRRPV-LIAFTVLAILTAYPALswLVAAP 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 336 SFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAIS 415
Cdd:PRK15075 330 SFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAAPGYWLSFAA 409
|
410
....*....|
gi 1450743514 416 VIGfLVITFL 425
Cdd:PRK15075 410 VCG-LIATLV 418
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
4-434 |
7.34e-62 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 207.35 E-value: 7.34e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 4 NKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFsPVENADIRQMLTFAALAIAFLLRPIGGVVFGII 83
Cdd:PRK10406 8 ADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFF-PSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 84 GDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLE 163
Cdd:PRK10406 87 ADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQY 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 164 IGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESpvfeNDVATQPERDNINFLQIIRfY 243
Cdd:PRK10406 167 VTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET----SQQETRALKEAGSLKGLWR-N 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 244 YKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTL 323
Cdd:PRK10406 242 RRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 324 FSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPT-MFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLvTKTG 402
Cdd:PRK10406 322 FTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVRALGVGLSYAVANALFGGSAEYVALSL-KSIG 400
|
410 420 430
....*....|....*....|....*....|..
gi 1450743514 403 DPLAPAYYLTAISVIGFLVITFLHLSTAGKSL 434
Cdd:PRK10406 401 METAFFWYVTLMAVVAFLVSLMLHRKGKGMRL 432
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-422 |
9.78e-62 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 204.76 E-value: 9.78e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 20 VVATGIGNAMEWFDFGVYAYTTAYIGANFfspveNADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIIL 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 100 MAFSTLTIGLLPSydqiglwaPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAV 179
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 180 LTFFLTDEqmasFGWRIPFLLGLFLGLFGLYLRRkleespvfendvatqperdniNFLQIIRFYYkdifvcfvavvFFNV 259
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLRR---------------------RTLLLILLWF-----------FISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 260 TNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLhSQSFVV 339
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL-SGSPTL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 340 IVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVAtWLVTKTGDPLAPAYYLTAISVIGF 419
Cdd:cd17316 271 LLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIA-LLLASTGGTGVPALILALLAIVAL 349
|
...
gi 1450743514 420 LVI 422
Cdd:cd17316 350 IVA 352
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
14-425 |
3.38e-56 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 192.64 E-value: 3.38e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 14 KKAKKTVVATGIGNAMEWFDFGVYAYTTAYI-GANFFSPVENAdirqMLTFAALA---IAFLLRPIGGVVFGIIGDKYGR 89
Cdd:PRK09952 18 SRARRAALGSFAGAVVDWYDFLLYGITAALVfNREFFPQVSPA----MGTLAAFAtfgVGFLFRPLGGVVFGHFGDRLGR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 90 KVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSG 169
Cdd:PRK09952 94 KRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 170 YIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVA-TQPERDNINFLQIIRFYYKDIF 248
Cdd:PRK09952 174 LLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHeQAAAKKRIPVIEALLRHPGAFL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 249 VCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDAT---TTSVLITCVMAIMIPLalmFGKLADKIGEKKVFLIGTGGLTLFS 325
Cdd:PRK09952 254 KIIALRLCELLTMYIVTAFALNYSTQNLGLPRElflNIGLLVGGLSCLTIPC---FAWLADRFGRRRVYITGALIGTLSA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 326 IIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPT-MFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDP 404
Cdd:PRK09952 331 FPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFTeMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYFGGS 410
|
410 420
....*....|....*....|..
gi 1450743514 405 LAP-AYYLTAISVIGFLVITFL 425
Cdd:PRK09952 411 WHSvAIYLLAGCLISAMTALLM 432
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-425 |
9.29e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 130.77 E-value: 9.29e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 14 KKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANF-FSPVEnadirqmlTFAALAIAFLLRPIGGVVFGIIGDKYGRKVV 92
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFgLSAAQ--------LGLLFAIPVLVGALLRIPLGFLVDRFGPRRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 93 LTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRnSLGSGLEIGtlSGYIA 172
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRR-GLALGLAAG--GGNLG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 173 ASIMIAVLTFFLtdeqmASFGWRIPFLLGLFLGLFGLYL-RRKLEESPVFENDVATQPERDninFLQIIRfyYKDIFVCF 251
Cdd:COG2223 142 AAVAAFLAPLLI-----AAFGWRNAFLILGILLLVVAVLaWLFLRDPPAGAAAAAKASLRD---QLEALR--DPRFWLLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 252 VAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFML 331
Cdd:COG2223 212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 332 LHsqSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISvSIFGGTTPLVATWLVTKTGDPLAPAYYL 411
Cdd:COG2223 292 LG--SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
410
....*....|....
gi 1450743514 412 TAISVIGFLVITFL 425
Cdd:COG2223 369 AVLALVALVLTLLL 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-425 |
1.31e-30 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 122.03 E-value: 1.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 21 VATGIGNAMEWFDFGVYAYTTAYIGANFfsPVENADIRQMLTFAALAIAfllrpIGGVVFGIIGDKYGRKVVLTSTIILM 100
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEF--GLDEAEAGLLGTVTLAGGA-----IGGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 101 AFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAAsimiAVL 180
Cdd:cd17371 75 AVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLA----TLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 181 TFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQII--RFYYKDIFVCFVAVVFFN 258
Cdd:cd17371 143 AALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELfsPPLLRTTLLASLLATGAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 259 VTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGlTLFSIIAFMLLHSqSFV 338
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALG-SAISILLYFFLPL-SPT 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 339 VIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIfGGTTPLVATWLVTKTGdpLAPAYYLTAISVIG 418
Cdd:cd17371 301 LILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGS--LGTAIAVFAAVYYI 377
|
....*..
gi 1450743514 419 FLVITFL 425
Cdd:cd17371 378 AGLVLAL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-381 |
1.16e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.54 E-value: 1.16e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 12 DAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANF-FSPVENAdirqmLTFAALAIAFLlrpIGGVVFGIIGDKYGRK 90
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLgASPAQAG-----LVVTAYLLGAA---LGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 91 VVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGY 170
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSL--------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 171 IAASIMIAVLTffltdeqmASFGWRIP-FLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDninflqiiRFYYKDIFV 249
Cdd:COG2814 148 ALGPLLGGLLA--------DLFGWRWVfLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE--------LLRRPRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 250 CFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAF 329
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI---GLLLLALGLL 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1450743514 330 MLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNI 381
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
18-435 |
1.32e-27 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 114.68 E-value: 1.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 18 KTVVATgIGNAMEWFDFGVYAYTTAYIGANFF-------SPVENADIRQMLTFAALAIAfllRPIGGVVFGIIGDKYGRK 90
Cdd:pfam00083 1 VALVAA-LGGFLFGYDTGVIGAFLTLIDFFKNfglsksvSSLAALSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 91 -VVLTSTIILMAFSTLTIGllpsydQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGtlsg 169
Cdd:pfam00083 77 kSLLIANVLFVIGAVLQGA------AKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLA---- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 170 yIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESP---------------------VFENDVATQ 228
Cdd:pfam00083 147 -ITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPrwlvekgrleearevlaklrgVPDVDRELD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 229 PERDNINFLQIIRFYYKDIFVCFVAVVFFNVTNYM------------VTAYLPTYLEQVIKLDATTTSVLITCVMAIMIP 296
Cdd:pfam00083 226 EIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMlqifqqltginaIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 297 LALMfgkLADKIGEKKVFLIGTGG----LTLFSIIAFMLLHSQSFVVIVIGIFILgFFLSTYEAT---MPGSLPT-MFYS 368
Cdd:pfam00083 306 IAIF---LVDRFGRRPLLLLGAAGmaicFVILGIVALLGVSKSDWAGIVAIVFIA-LFIAFFAMGwgpVPWVIVSeLFPL 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 369 HIRYRTLSVTFNISVsIFGGTTPLVATWLVTKTGDPLAPAYYLtAISVIGFLVITFLHLSTAGKSLK 435
Cdd:pfam00083 382 SVRSKAMALATAANW-LANFLIGFLFPIITDAIGLGYTFFIFA-GLLVLFIIFVFFFVPETKGRTLE 446
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-218 |
2.45e-27 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 111.06 E-value: 2.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 7 NINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFfspveNADIRQMLTfaALAIAFLLRPIGGVVFGIIGDK 86
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADL-----GASSAQLGW--IVSAYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 87 YGRKVVLTSTIILMAFSTLTIGLLPSydqiglwaPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGT 166
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1450743514 167 LSGYIAASIMIAVLTffltdeqmASFGWRIPFLLGLFLGLFGLYLRRKLEES 218
Cdd:COG0477 148 GLGLALGPLLGGLLV--------AALGWRWIFLINAPLGLLALVLRLRLPES 191
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-425 |
7.37e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 108.03 E-value: 7.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 14 KKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANF-FSPVEnadirqmlTFAALAIAFLLRPIGGVVFGIIGDKYGRKVV 92
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLgLSAAQ--------LGLLASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 93 LTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIA 172
Cdd:COG2271 78 LAIGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 173 ASIMIAVLtffltdeqMASFGWRIPFLLGLFLGLFGLYLRrkleespvfendvatqperdninflqiirfyykdIFVCFV 252
Cdd:COG2271 150 APPLLGWL--------LAAFGWRAAFLILGLPGLLLALLR----------------------------------FWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 253 AVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGtGGLTLFSIIAFMLL 332
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 333 HSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTfNISVSIFGGTTPLVATWLVTKTGDPLApAYYLT 412
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYLLDATGYQAA-FLLLA 344
|
410
....*....|...
gi 1450743514 413 AISVIGFLVITFL 425
Cdd:COG2271 345 ALALLAALLALLL 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-425 |
4.81e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.04 E-value: 4.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 61 LTFAALAIAFLlrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTGGEYA 140
Cdd:cd17325 35 LIVAAYALAQL---LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 141 GAMTYVAESSPDKRRnslgsGLEIGTLSGYIAASIMI-AVLTFFLTDeqmaSFGWRIPFLLGLFLGLFGLYLR-RKLEES 218
Cdd:cd17325 104 AAMALIADIAPPEER-----GRAMGIFSSAIGLGFLIgPLLGGLLAD----ALGYRAPFLVCAALALLALVLAlLLLPEP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 219 PVFENDVATQPERDNINFLQIIRfyYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLA 298
Cdd:cd17325 175 RPPPNKRAVSAARLRSGLRLLLR--DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 299 LMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMpGSLPTMFYSHIRYRTLSVT 378
Cdd:cd17325 253 PPAGKLSDRIGRKPLILI---GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT-LALLADIVPPEGRGTAMGL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1450743514 379 FNISVSIFGGTTPLVATWLVTKTGdpLAPAYYLTAISVIGFLVITFL 425
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
65-391 |
3.36e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.55 E-value: 3.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 65 ALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMT 144
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 145 YVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVLTffltdeqmASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFEND 224
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 225 VATqPERDNINFLQIIRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEqVIKLDATTTSVLITCVMAIMIPLALMFGKL 304
Cdd:pfam07690 181 KPA-EEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 305 ADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVtFNISVS 384
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL-YNTAGS 337
|
....*..
gi 1450743514 385 IFGGTTP 391
Cdd:pfam07690 338 LGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-421 |
4.00e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.94 E-value: 4.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 36 VYAYTTAYIGANFFSPVENADIRQM-LTFAALAIAFLLRPIGGVVFGIIG----DKYGRKVVLTSTIILMAFSTLTIGLL 110
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFgLSASQLGLLFALFSLGYALLQPLAgllaDRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 111 PSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVLTffltdeQMA 190
Cdd:cd06174 82 PSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 191 SFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQIIR-FYYKDIFVCFVAVVFFNVTNYMVTAYLP 269
Cdd:cd06174 148 GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRvLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 270 TYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADK-IGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILG 348
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1450743514 349 FFLStyeaTMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFLV 421
Cdd:cd06174 308 GGLL----PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
18-237 |
3.84e-17 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 83.59 E-value: 3.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 18 KTVVATGIGNAMEWFDFGVYAYTTAYIGANF-FSPVENAdirqmltfAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTST 96
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEVQGEFgLTTVQAA--------SLISAAFISRWFGGLLLGAMGDRYGRRLAMVIS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 97 IILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLeigtLSGYiaaSIM 176
Cdd:PRK03893 92 IVLFSVGTLACGFAPGY--------WTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGF---SIG 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1450743514 177 iAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQ-PERDNINFL 237
Cdd:PRK03893 157 -AVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKaPVRTMVDIL 217
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
29-398 |
5.47e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 76.63 E-value: 5.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 29 MEWFDFGVYAYTTAYIGANFfsPVENADIRQMLTFAALAIAFllrpiGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIG 108
Cdd:TIGR00895 28 MDGYDLAAMGFAAPAISAEW--GLDPVQLGFLFSAGLIGMAF-----GALFFGPLADRIGRRRVLLWSILLFSVFTLLCA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 109 LLPSYDQiglwapilLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSL----GSGLEIGTLSGYIAASIMIAVltffl 184
Cdd:TIGR00895 101 LATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAvglmFCGYPIGAAVGGFLAGWLIPV----- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 185 tdeqmasFGWRIPFLLGLFL-GLFGLYLRRKLEESPVF----------------------ENDVATQPERDNINFLQIIR 241
Cdd:TIGR00895 168 -------FGWRSLFYVGGIApLLLLLLLMRFLPESIDFlvskrpetvrrivnaiapqmqaEAQSALPEQKSTQGTKRSVF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 242 F------YYKDIFVCFVAVVFFNVTNYMVTAYLPtYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFL 315
Cdd:TIGR00895 241 KalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 316 IGTGGLTLFSIIAFMLlhsQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNIS--VSIFGgttPLV 393
Cdd:TIGR00895 320 LLLLGAVFAVLVGSTL---FSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGrlGAIIG---PIL 393
|
....*
gi 1450743514 394 ATWLV 398
Cdd:TIGR00895 394 AGYLL 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-350 |
6.62e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.05 E-value: 6.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 59 QMLTFAALAIAfllrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGE 138
Cdd:cd17324 38 LLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF--------ALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 139 YAGAMTYVAESSPDKRRNS----LGSGLEIGTLSGYIAASIMiavltffltdeqMASFGWRIP-FLLGLFLGLFGLYLRR 213
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRaiglVFSGLTLGLVLGRPLGGLL------------GQLLGWRAAfLAIAVLALLAALLLWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 214 KLEESPVFENdvatQPERDNINFLQIIRFyyKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAI 293
Cdd:cd17324 173 LLPSLPPKKP----GSLGLLSSLLLLLRN--PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 294 MIPLALMFGKLADKIGEKkvFLIGTGGLTLFSIIAFMLLHSQSFVVIViGIFILGFF 350
Cdd:cd17324 247 GVVGSPLAGRLADRGGRR--ALLIALLLLAAALLLLTLLGPSPLLLLV-GLVLWGLG 300
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
17-424 |
7.01e-15 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 76.51 E-value: 7.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 17 KKTVVATGIGNAMEWFDFGVYAYTTAYIGANFfspvenaDIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTST 96
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADL-------GLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 97 IILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSP----DKRRNSLGSGLEIGTLsgyIA 172
Cdd:PRK12307 90 IVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPkhlkSKASAFLVSGFGIGNI---IA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 173 ASIMiavltffltdEQMA-SFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQIIRFYYKDIFVCF 251
Cdd:PRK12307 159 AYFM----------PSFAeAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 252 VAVVFFNV---------TNYMVTAYLPTYLEQViKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLT 322
Cdd:PRK12307 229 QFPLTLCVfivlfsifgANWPIFGLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSF 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 323 LFSIIAFMLLHSQSfvvIVIGIFILGFFLSTyeATMPGSLPTMFYSH--IRYRTLSVTFNISVSIFGGT-TPLVATWLVT 399
Cdd:PRK12307 308 LFIFPLFRIPQDNY---LLLGACLFGLMATN--VGVGGLVPKFLYDYfpLEVRGLGTGLIYNLAATSGTfNSMAATWLGI 382
|
410 420
....*....|....*....|....*
gi 1450743514 400 KTGDPLAPAYYLTAISVIGFLVITF 424
Cdd:PRK12307 383 TMGLGAALTFIVAFWTATILLIIGL 407
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-427 |
7.58e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.61 E-value: 7.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 46 ANFFSPVENADIRQMLTFAALAIAfllrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLL 125
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLPALFIA-----LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------YALL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 126 LARVLQGFSTGGEYAGAMTYVAESSPDKRRNslgsgleigTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLG 205
Cdd:cd17473 93 ASRALLGIGVAGIMTLATALIGDYFEGEERA---------KMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 206 LFGLYLRRKLEESPVfendvaTQPERDNINFLQIIRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSV 285
Cdd:cd17473 164 PVLILVLLFLPEPAR------KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 286 LITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTyeaTMP-GSLPT 364
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAI---GFALMALGFLLLALASGLWVVLLGAILAGLGFGL---LLPtLNSWA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1450743514 365 MFYSHIRYRTLSVTFnISVSIFGG--TTPLVATWLVTKTGDPLApAYYLTAISVIGFLVITFLHL 427
Cdd:cd17473 312 MSLVPPELRGRAMGI-VTSAFFLGqfLSPLVLGPLVNLTGGLSG-AFLILGVLALVLAIVLLLLR 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
75-425 |
9.82e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 66.05 E-value: 9.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSydqiglwaPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17319 53 LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS--------LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 155 RnslGSGLEIGTLSGYIAASIMIAVLTFFLTdeqmaSFGWRipfllglflglfglylrrkleESPVFENDVAtqperdnI 234
Cdd:cd17319 125 R---GRATGLFNSGAPLGAAIGPPLSGWLLL-----LFGWR---------------------WAFIIEGLLG-------L 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 235 NFLQIIRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVF 314
Cdd:cd17319 169 LLAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARR 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 315 LIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPgSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVA 394
Cdd:cd17319 249 LVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW-SLPADLLPGEAAATAGGLINSGGNLGGFVAPLLI 327
|
330 340 350
....*....|....*....|....*....|.
gi 1450743514 395 TWLVTKTGDPLAPAYYLTAISVIGFLVITFL 425
Cdd:cd17319 328 GYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
61-359 |
2.87e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.31 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 61 LTFAALAIAFLLRPIGGVV----FGIIGDKYG-----RKVVLTSTIILMAFSTLTIGLLPSYDQIG--LWAPILLLLARV 129
Cdd:COG2211 43 LSAALVGLILLVARLWDAItdplIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 130 LQGFSTggeyAGAMTYVAESSPD-KRRNSLGSGLEIGTLSGYIAASIMIAVLTFFLTDEQmaSFGWRIPFLLGLFLGLFG 208
Cdd:COG2211 123 AYTLVN----IPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 209 LYLrrkleesPVFENDVATQPERDNINFLQIIR--FYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVL 286
Cdd:COG2211 197 FLL-------TFFGTKERPVPEEEKVSLKESLKalLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLL 269
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1450743514 287 ITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFmLLHSQSFVVIVIGIFILGFFLSTYEATMP 359
Cdd:COG2211 270 LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-FLGPGNLWLLLVLAALAGIGLGAILVLPW 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-461 |
2.31e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 61.67 E-value: 2.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 260 TNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVV 339
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI---GLLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 340 IVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVtFNISVSIFGGTTPLVATWLVTKTGdpLAPAYYLTAISVIGF 419
Cdd:pfam07690 88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFG--WRAAFLILAILSLLA 164
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1450743514 420 LVITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWV 461
Cdd:pfam07690 165 AVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL 206
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
60-349 |
8.72e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 8.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 60 MLTFAALAiafllrpiggVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSydqiglwaPILLLLARVLQGFSTGGEY 139
Cdd:cd17321 41 LLAFAALL----------LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 140 AGAMTYVAESSPDKRRNS----LGSGLEIGTLSGYIAASIMIAVltffltdeqmasFGWRipfllglflglfglylrrkl 215
Cdd:cd17321 103 PASLALIAATFPGERRGRalglWGAVVGIGAALGPLLGGLLLEL------------FGWR-------------------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 216 eesPVFendvatqpeRDNINFLQIIRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMI 295
Cdd:cd17321 151 ---WIF---------LINVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1450743514 296 PLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGF 349
Cdd:cd17321 219 VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGL 272
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
60-425 |
9.03e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.25 E-value: 9.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 60 MLTFAALAIAFLlrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEY 139
Cdd:COG0738 46 GLLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 140 AGAMTYVAESSPDKRR---NSLGSGLEIGTLSGYIAASIMIAVLtffltdeqmASFGWRIPFLLGLFLG--LFGLYLRRK 214
Cdd:COG0738 115 VAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLILLG---------LSLSWHLPYLILAVLLllLALLFLRSK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 215 LEESPvfenDVATQPERDNINFLQIIRFyyKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIM 294
Cdd:COG0738 186 LPEIE----EEEEEAAGSAASLKSLLKN--PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 295 IPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAfmlLHSQSFVVIVIGIFILGFFLStyeATMPGSLPTMFYSHIRYRT 374
Cdd:COG0738 260 TIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA---LLAPGPWLALIGLALVGLGLS---LMFPTIFSLALDGLGKRTA 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1450743514 375 LSVTFNISVSIFGGTT-PLVATWLVTKTGdpLAPAYYLTAISVIGFLVITFL 425
Cdd:COG0738 334 AAVSAVLIMGIVGGAIgPPLIGFLADAFG--LRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
67-215 |
2.45e-09 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 58.83 E-value: 2.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 67 AIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLlpSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYV 146
Cdd:cd17364 46 AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSAL--SPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIM 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1450743514 147 AESSPDKRRNSL----GSGLEIGTLSGYIAASIMIAVL--TFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKL 215
Cdd:cd17364 124 SEYANKKRRGALiaavFAMQGFGILAGAIVTLILSAIFehPLPAGTYHHADLVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
60-424 |
7.36e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.18 E-value: 7.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 60 MLTFAALAIAFLLRPiggvVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwaPILLLLArVLQGFSTGGEY 139
Cdd:cd17478 35 LLVSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-------WLLLLLV-ALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 140 AGAMTYVAESSPDKRrnslGSGLEIGTLSGYIAASIM-IAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEES 218
Cdd:cd17478 103 PEGARLASQAAGGRR----GLAMSIFSVGGNLGFALGpLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 219 PVFENDVATQPERDNINFLQIIrfyykdifvcFVAVVFFNVTNYMVTAYLPTYLEQViKLDATTTSVLITCVMAIMIPLA 298
Cdd:cd17478 179 KAAAKSSARSTLKGVWRALLLL----------LIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 299 LMFGKLADKIGEKKVFLIGTGGLTLFsIIAFMLLHSqsfVVIVIGIFILGFFLStyeATMPGSLpTMFYSHI-RYRTL-- 375
Cdd:cd17478 248 LIGGPLSDRFGRRRVIIASLLLAAPF-LLLFLLTPG---IWSYILLVLAGFLLF---ASFPVTV-VLAQELLpGNVGLas 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1450743514 376 SVTFNISVSIfGGTTPLVATWLVTKTGdpLAPAYYLTAISVIGFLVITF 424
Cdd:cd17478 320 GLMMGLSFGL-GGIGAPVLGALADAFG--LESVLLILALLPLLGALLAF 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
61-426 |
8.25e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.22 E-value: 8.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 61 LTFAALAIAFLLRPIGGvvfgIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSydqiglwaPILLLLARVLQGFSTGGEYA 140
Cdd:cd17489 36 VVGLFTLAALLARPFAG----RLLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 141 GAMTYVAESSPDKRRnslGSGLEIGTLSGYIAASIMIAVLTFFLtdeQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPV 220
Cdd:cd17489 104 AAATLVADIIPPSRR---GEGIGYYGLATTLAMALGPALGLFLY---QHLGFAVLFIVAAVLALLALLLVFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 221 FENDVATQPERDninflqiiRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQvikLDATTTSVLITCVMAIMIPLALM 300
Cdd:cd17489 178 AEEAEAGTRAFR--------RLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTVYAIALLLSRPF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 301 FGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGF----FLSTYEATMPGSLPtmfySHIRYRTLS 376
Cdd:cd17489 247 SGKLSDRKGPKTVIIP---GLLLLALGLLLLSFAGSPWMLLLAAVLYGLgfglLFPALQALAVDLVP----PHRRGAANG 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1450743514 377 vTFNISVSIFGGTTPLVATWLVTKTGdpLAPAYYLTAI-SVIGFLVITFLH 426
Cdd:cd17489 320 -TFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVvVLLALVLYIFLL 367
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-425 |
8.84e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.24 E-value: 8.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 60 MLTFAALAIAFLLRPIGGVvfgiIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLAR-VLQGFSTGGE 138
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGV----LADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLgIASAFFGPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 139 YAGAMTYVAESSPDkRRNSLGSGLE-IGTLSGYIAASIMIAVL---TFFLTDeqMASFGwripfllglFLGLFGLYLRRK 214
Cdd:cd06173 114 QALLPELVPKEQLV-RANALNSLATqLARIIGPALGGLLVALLgpgGAFAIN--ALSFL---------LSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 215 LEESPVFENDVATQperdniNFLQIIRFYYKD--IFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMA 292
Cdd:cd06173 182 PPAAPGESSSLLLR------DLREGLRYLRRSplLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 293 IMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMllhSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRY 372
Cdd:cd06173 256 GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1450743514 373 RTLSVtFNISVSIFGGTTPLVATWLVTKTGdpLAPAYYLTAISVIGFLVITFL 425
Cdd:cd06173 333 RVFSV-YNALNSGAMPLGALLAGLLADALG--LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
30-197 |
5.03e-08 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 54.51 E-value: 5.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 30 EWFDFGVYAYTTAyigaNFFSPVENADIRQMLTFAALAIAFLlrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGL 109
Cdd:cd17317 2 WEFDYSVSESTIV----TEWDLVCDRDWLVALVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 110 LPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYiaasIMIAVLTFFLTDEQM 189
Cdd:cd17317 75 SPSY--------ELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGY----MLLALLAYLIRDWRW 142
|
....*...
gi 1450743514 190 ASFGWRIP 197
Cdd:cd17317 143 LQLAISLP 150
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
262-425 |
5.35e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.88 E-value: 5.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 262 YMVTAYLPTYLEQvIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFV--V 339
Cdd:COG2807 232 YAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWlwA 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 340 IVIGIFILGFFlstyeaTMPGSLPTM-FYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIG 418
Cdd:COG2807 311 VLLGLGQGGLF------PLALTLIGLrARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLM 384
|
....*..
gi 1450743514 419 FLVITFL 425
Cdd:COG2807 385 LVAGLLA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
64-421 |
9.94e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.81 E-value: 9.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 64 AALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQiglwapiLLLLARVLQGFSTGGEYAGAM 143
Cdd:cd17355 42 LAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLLGGGGAGTLAAVAF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 144 TYVAESSPDKRRnslGSGLEIGTLSGYiAASIMIAVLTFFLTDEqmasFGWR-----IPFLLGLFLGLFGLYLRRKLEES 218
Cdd:cd17355 115 ATVAAWWFERRR---GLALGILTAGGG-LGSLVFLPLGAALIEA----FGWRtallvLALLALLVLVPVLLLLRRRPADL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 219 PVFENDVATQPERDNInFLQIIRfyYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQvIKLDATTTSVLITCVMAIMIPLA 298
Cdd:cd17355 187 ALRAYDDASPASPGST-LKEALR--SASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 299 LMFGKLADKIGEKKVFLIGTgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTyeATMPGSLPTMFYSHIRYRTLSVT 378
Cdd:cd17355 263 LLSGWLGDRYSPRRLLAASY-ALRALGLALLLLLPFPPLALLLFAALFGLGWGAT--VPLTAALAARYFGARSYGTLFGL 339
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1450743514 379 FNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFLV 421
Cdd:cd17355 340 VFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALL 382
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
67-226 |
1.09e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 53.96 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 67 AIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWApiLLLLARVLQGFSTGGEYAGAMTYV 146
Cdd:TIGR00887 63 GSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIIT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 147 AESSPDKRRNSLGSGL----EIGTLSGYIaasIMIAVLTFFLTDEQMASFG--------------WRIPFLLGLFLGLFG 208
Cdd:TIGR00887 141 SEFATKKWRGAMMAAVfamqGFGILAGAI---VALIVLAGFKHSLEAAADEasctgscvpavdymWRILIGFGAVPALLA 217
|
170
....*....|....*...
gi 1450743514 209 LYLRRKLEESPVFENDVA 226
Cdd:TIGR00887 218 LYFRLTIPETPRYTADVA 235
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
75-196 |
1.12e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.74 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWapillllaRVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17365 49 IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1450743514 155 RNSLGSgleiGTLSGYIAASIMIAVLTFFLTDeqmaSFGWRI 196
Cdd:cd17365 121 RSLAVT----LMFCGYPLGAALGGFLAAALIP----AFGWRS 154
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
79-425 |
1.40e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 53.34 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 79 VFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRnsl 158
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--------ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGER--- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 159 gsgleiGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPvfendVATQPERDNINFLQ 238
Cdd:cd17474 122 ------AKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEP-----KEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 239 IIRFY-YKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLItCVMAIMIPLALMFGK--LADKIGEKKVFL 315
Cdd:cd17474 191 LKKALrGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLF-AGWSVLLALGSLFVGrlLKKRFGARRILV 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 316 IgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVtfNISVSIFGGTT-PLVA 394
Cdd:cd17474 270 I---GLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL--YNFVRFLGQAVgPLLF 344
|
330 340 350
....*....|....*....|....*....|.
gi 1450743514 395 TWLVTKTGDPlAPAYYLTAISVIGFLVITFL 425
Cdd:cd17474 345 GLLLEIFGLS-APFLVGAAIALAAAVLLALL 374
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
75-424 |
1.69e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 53.34 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 155 RNSLGSGLEIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPvfendvatqperdni 234
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESP--------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 235 NFLQIIRFYYKDIFVCFVAVVFFNVTNyMVTAYLPTYLEQVIKldATTTSVLITCVMAIMIPLALMFG-KLADKIGEKKV 313
Cdd:cd17359 188 RWLVSKGKPILIIGIGLAIFQQFVGIN-VIFYYGPEIFQNAGF--SENAALLQTIGIGVVNVIFTIIAiLLVDKVGRKPL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 314 FLIGTGGLTLFSII-----AFMLLHSQSFVVIVIGIFI-LGFFLSTYEATMPGSLPTMFYSHIRYRTLSVT------FNI 381
Cdd:cd17359 265 LLIGSIGMAISLLLigtafYFAPGSQASGIVALVLILLfVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAvfflwiANF 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1450743514 382 SVSIFggTTPLVATWlvtktgdPLAPAYYL-TAISVIGFLVITF 424
Cdd:cd17359 345 LVSLT--FPILLAAF-------GLAFTFLIfAVICVLAFLFVWK 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
262-427 |
2.08e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.81 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 262 YMVTAYLPTYLEQViKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIaFMLLHSqsFVVIV 341
Cdd:cd06174 13 GLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL-FAFAPS--FWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 342 IGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVtFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFLV 421
Cdd:cd06174 89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAI 167
|
....*.
gi 1450743514 422 ITFLHL 427
Cdd:cd06174 168 LLLLVV 173
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
81-352 |
5.31e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.42 E-value: 5.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 81 GIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRnslgs 160
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKR----- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 161 gleiGTLSGYIAASIMIA-----VLTFFLTDeqmaSFGWR----IPFLLGLFLGLFGLYLRRKLEESPVFENDVAtqper 231
Cdd:cd17503 119 ----GAAMGLVGLVILLApaigpTLGGWLTD----NLSWRwifyINLPIGILALLLAPLLDLRLFKDRNFTLGLL----- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 232 dnINFLQIIRFYykdifvcfvavvffnvtnyMVTAYLPTYLEQVIKLDATTTSVLIT---CVMAIMIPLAlmfGKLADKI 308
Cdd:cd17503 186 --LSFLLGLGLF-------------------GAMFLLPLYLQNVLGYSAFESGLVLApggLASAILSPLV---GRLLDKF 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1450743514 309 GEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLS 352
Cdd:cd17503 242 GPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMG 285
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-349 |
6.09e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 51.03 E-value: 6.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 19 TVVATGIGNAMEwfDFGVYA----YTTAYiganffspvenadirqMLTFAALAiafllrPIggvvFGIIGDKYGRKVVLT 94
Cdd:cd17502 13 TIVATALPTIVA--EFGGLSlvswVGTAY----------------LLTSTAFQ------PI----YGKLSDLFGRKWVLL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 95 STIILMAFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRnslgsgleiGTLSGYIAAS 174
Cdd:cd17502 65 IAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSLAFIIIADLVPPRER---------GKYQGYIGAV 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 175 IMIA-----VLTFFLTDeqmaSFGWRIPFLLGLFLGLFGLYLRRkleespvfendvatqperdNINFLQIIRFyykdifv 249
Cdd:cd17502 128 FGIAsvagpLIGGAFTD----HLSWRWCFYINLPIGGLALALLR-------------------TILLSSIFGF------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 250 cfvavvFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAF 329
Cdd:cd17502 178 ------LFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLL 251
|
330 340
....*....|....*....|.
gi 1450743514 330 MLLHSQSFVVIVIG-IFILGF 349
Cdd:cd17502 252 TTLTLDTSKWLLIGyLILLGL 272
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
75-434 |
6.60e-07 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 51.48 E-value: 6.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILmaFSTLTIGLLPSYDQIGLwapilLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI--YIIGAIIQVAAIGKWYQ-----LIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 155 RNSLgsgleIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPvfendvatqperdni 234
Cdd:cd17356 133 RGTL-----VSLYQLAITIGILVAYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESP--------------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 235 nflqiiRFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDAT--TTSVLITCVMAIMIPLALMFgklADKIGEKK 312
Cdd:cd17356 193 ------RWLYRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSplLTSIILYIVNFVSTIPGLFF---VDKFGRRT 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 313 VFLIGTGGLTLFSIIAFMLLHSQSFV-------------VIVIGIFILGFFLSTYEATMPGSLPTMFYSHiRYRTLSVTF 379
Cdd:cd17356 264 CLLIGAAGMSICLFIYAAVGVRYLIPnpqsgtsnksagnGMIVFICLFIFSFATTWGPIAWVYVAEVFPL-RVRSKGMAL 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 380 NISVSIFGGTTPLVATWLVTKTgdpLAPAYYL--TAISVIGFLVITFLHLSTAGKSL 434
Cdd:cd17356 343 ATAFNWLWNFLISFFTPFIIGS---IGFKYYYifAGCNLLAFIVVFFFVPETKGLTL 396
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
271-430 |
7.34e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 7.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 271 YLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFF 350
Cdd:COG2271 35 PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI---GLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 351 LSTYEATMPGSLPTMFYSHIRYRTLSVtFNISVSIFGGTTPLVATWLVTKTGdpLAPAYYLTAISVIGFLVITFLHLSTA 430
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLLAAFG--WRAAFLILGLPGLLLALLRFWLLALA 188
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
64-425 |
2.43e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 64 AALAIAFLLrpiGGVVFGIIGDKYGRKVVLtstIILMAFSTLTIGLLPSYDQIGLWapillLLARVLQGFSTGGEYAGAM 143
Cdd:cd17477 38 SAYYLGILL---GSPLVPRLIRRVGHIRAF---AAGAAITAVSVLLLALTDSPWVW-----FLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 144 TYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVltffltdeqMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFen 223
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL---------VGTAGALPFLIAAVLLLLALVPLLLTRRAAPEI-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 224 dvatqPERDNINFLQIIRFyykdIFVCFVAVVFFNVTNYMVTAYLPTYLEQViKLDATTTSVLITCVMAIMIPLALMFGK 303
Cdd:cd17477 176 -----EEAESISLRRLLRI----APLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 304 LADKIGEKKVfLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMpgSLPTMFYSHIRYRTLSVTFNISV 383
Cdd:cd17477 246 LADRFDRRRV-LLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLAL--ALAGDRLPGDELVAANAALLLLY 322
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1450743514 384 SIFGGTTPLVATWLVTKTGdplaPAYYLTAISVIGFLVITFL 425
Cdd:cd17477 323 GLGSVIGPLLAGALMDAFG----PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
75-434 |
3.26e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 49.27 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDqiglwapiLLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 155 RNSLGS----GLEIGTLSGYIAASIMIAVLTffltdeqmasfGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDvatqpe 230
Cdd:cd17362 126 RGLLVSlkelFIVLGILLGYVSGYAFADVVG-----------GWRYMYGLAAPPALLLGIGMWFLPPSPRWQGN------ 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 231 rdninflqiirfYYKDIFVCFVAVVFFNVTNY-MVTAYLPTYLEQV---IKLDATTTSVLITCVMAIMIPLALMfgkLAD 306
Cdd:cd17362 189 ------------YRKPLIIGLGLVLFQQITGQpSVLYYAATIFKSAgfsAASDATLVSVGLGVFKLLMTIVAVL---LVD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 307 KIGEKKVFLIGTGGLT--LFSI-IAFMLLHSQSFVVIVIGIFILGFFLSTYEATMpGSLPTMFYSHI-RYRTLSVTFNIS 382
Cdd:cd17362 254 KLGRRPLLLGGVSGMVvsLFLLaAYNLFVQMGPAGLAWLSLVALLLYVGAYQISF-GPISWLMVSEIfPLRVRGRAIALA 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1450743514 383 VSIFGGTTPLVATWLVTKTGDPLAPAYYL--TAISVIGFLVITFLHLSTAGKSL 434
Cdd:cd17362 333 VLVNFGSNALVSLAFLPLQELIGLPGTFLgfGVIGVLALLFIYFTVPETKGLSL 386
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
75-425 |
9.03e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 47.57 E-value: 9.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 155 RNSLGSGLEIGTLSGYIAASIMIAVLtffltdEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVAtqperdnI 234
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLAL------SLSPPGWWRLMFALAAVPALLQLLLMFFLPESRALLVGVG-------L 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 235 NFLQ----IIRFYYkdifvcfvavvffnvtnymvtaYLPTYLEQvikLDATTTSVLIT-CVMAIMIPLALMFGKLADKIG 309
Cdd:cd17315 188 QLLQqltgINAVMY----------------------YAPTIFKS---AGGGTASILASiIVGVVNLLATLVAIRLVDKVG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 310 EKKVFLIGTGGLTLFSI---IAFMLLHSQSFVVIVIGIFILGFFLSTyeATMPGSLPTMFYSHI---RYRTLSVTFNISV 383
Cdd:cd17315 243 RRPLLLIGFAGMAASLLllaIAFLLPALAKAAGWLALLGILLYIAAF--AMGAGPVPWLLLSEIfplRIRGKGMAIATLV 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1450743514 384 S-----IFGGTTPLVatwlVTKTGdpLAPAYYL-TAISVIGFLVITFL 425
Cdd:cd17315 321 NwifnfIVGLTFLIM----VSTIG--LAGVFIFfAAVCLLALVFVFFF 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
271-425 |
1.01e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 271 YLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFF 350
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL---GLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 351 LSTYEATMpGSLPTMFYSHIRYRTLSVT--FNiSVSIFGGttPLVATWLVTKTGDPLAPAYYLTAISVIGFLVITFL 425
Cdd:COG0738 110 LGLLDVAA-NPYVAALGPETAASRLNLLhaFF-SLGALLG--PLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL 182
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
75-155 |
1.19e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 47.70 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
.
gi 1450743514 155 R 155
Cdd:TIGR00898 214 R 214
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
65-351 |
1.25e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.26 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 65 ALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTgGEYAGAMT 144
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGVFS-GYVPNATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 145 YVAESSPDKRrnslgSGLEIGTLS-GYIAASIMIAVLTFFLTDeqmaSFGWR----IPFLLGLFLGLFGLYLrrkleesp 219
Cdd:cd17391 112 LIASQTPKEK-----SGWALGTLStGVVAGTLIGPLLGGFLAD----LFGIRnvffITGGLLFLAFLLTLFF-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 220 VFENDVATQPERDnINFLQIIR--FYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQV--IKLDATTTSVLITCVMAIM- 294
Cdd:cd17391 175 VKEDFKPVEKKKM-VSTKEVWNsvPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLmgDASNLAFISGLVFSATGVSs 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 295 IPLALMFGKLADKIGEKKVFLIGtggltlfSIIAFMLLHSQSFVVIVIGIFILGFFL 351
Cdd:cd17391 254 LLSAPRLGKLGDRIGHHRILLGA-------LLASALLYIPQAFVQTPWQLGILRFLL 303
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
60-176 |
1.26e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.57 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 60 MLTFAAlaiafllrPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEY 139
Cdd:cd17358 49 LLTLGA--------LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDV--------WMLYLGRFLAGFGGGAAS 112
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1450743514 140 AGAMTYVAESSPDKRRNSLGSGLE----IGTLSGYIAASIM 176
Cdd:cd17358 113 VVVPVYIAEIAPKNVRGALGSLNQllvnIGILLGYVLGSFL 153
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
261-402 |
1.54e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.73 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 261 NYMVTAYLPTyLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMllhSQSFVVI 340
Cdd:COG0477 30 FTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL---APSPELL 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1450743514 341 VIGIFILGFFLStyeATMPGSLPTMF-YSHIRYRTLSVTFNISVSIFGGTT-PLVATWLVTKTG 402
Cdd:COG0477 106 IAARALQGIGAG---GLMPGALALIAeLFPARERGRALGLWGAAIGLGLALgPLLGGLLVAALG 166
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
75-176 |
3.48e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.10 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSydqigLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKR 154
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKS-----AKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100
....*....|....*....|..
gi 1450743514 155 RNSLGSGLEIGTLSGYIAASIM 176
Cdd:cd17357 139 RGALGSLTQIGVTLGILLGQVF 160
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
262-358 |
3.86e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.68 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 262 YMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTgGLTLFSIIAFMLLHsqSFVVIV 341
Cdd:cd17329 16 FMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGL-LLRALGFALLGFAH--SPWLFA 92
|
90
....*....|....*..
gi 1450743514 342 IGIFILGFFLSTYEATM 358
Cdd:cd17329 93 IALVLTGFGGGLFEPAS 109
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
263-425 |
5.34e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 263 MVTAYLPTyLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVI 342
Cdd:cd17474 17 IVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLP---GLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 343 GIFILGF---FLSTYEATMPGSLptmfySHIRYRTLSVTFNISVSIFGGTT-PLVATWLVTKtgDPLAPAYYLTAISVIG 418
Cdd:cd17474 93 GRALQGIgaaGLGPLALTLIGDL-----FEGGERAKAMGLYEAALGLGIAVgPLLGGLLAAI--SWRYPFFLLAALIPVA 165
|
....*..
gi 1450743514 419 FLVITFL 425
Cdd:cd17474 166 FLAILFL 172
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
79-359 |
1.05e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 79 VFGIIGDKYGRKVVLtstIILMAFstLTIGLLpsydqIGLWAP--ILLLLARVLQGFStGGEYAGAMTYVAESSPDKRRn 156
Cdd:cd17504 50 ILGRLGDLYGRKKVL---LIVLAI--YTAGSL-----LAAFAPnlPVLIAGRALQGIG-GAVFPLAFALVREEFPPERV- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 157 slgsGLEIGTLSGYIAASIMIA-VLTFFLTDeqmaSFGWRIPFLLGLFLGLFGLYLrrkleeSPVFENDVATQPerdNIN 235
Cdd:cd17504 118 ----PVAQGILSATFGIGAGIGlPLGGWIVQ----HLGWRWIFWTAAPVAVLLAAL------VPLIDLRLLRRR---NVL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 236 FLQIIRFyykdifvcfvavvFFNVTNYMVTAYLPTYLEQ----VIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEK 311
Cdd:cd17504 181 LANITAL-------------LAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1450743514 312 KVFLIGTgGLTLFSIIAFMLLHSqSFVVIVIGIFILGFFLSTYEATMP 359
Cdd:cd17504 248 RVLLIGL-VISAVGLLLLALLHS-SLWALVVALLLIGIGLGLAFASLP 293
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
268-361 |
1.73e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 268 LPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLtlfSIIAFMLLHSQSFVVIVIGIFIL 347
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLM---GAAALLMALVGSYPVLLVLLFLV 94
|
90
....*....|....
gi 1450743514 348 GFFLSTyeATMPGS 361
Cdd:cd17475 95 GAGYGS--VQPGGG 106
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
267-353 |
2.22e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.34 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 267 YLPTYLEQvIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTgglTLFSIIAF--MLLHSQSFVVIVIGI 344
Cdd:cd17335 19 FLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLS---LLAAVLFFlsLFFVAQIFWLLLLLV 94
|
....*....
gi 1450743514 345 FILGFFLST 353
Cdd:cd17335 95 ILGAFFSAP 103
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
59-421 |
2.24e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 59 QMLTFAALAIAFLLRPIGGVVFGIIG----DKYGRKVVLTSTIILMAFSTLTIGLLPSydqiglwaPILLLLARVLQGFS 134
Cdd:cd17329 30 LGLSASIVGLVLALSAVAGIVASLIGgrlaDRFGRKPVMLAGLLLRALGFALLGFAHS--------PWLFAIALVLTGFG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 135 TGGEYAGAMTYVAESSPDKRR----NSLGSGLEIGTLSGYIAASIMIavltffltdeqMASFGWRIPFLLGLFLGLFGLY 210
Cdd:cd17329 102 GGLFEPASEAMIADVTTPENRtrafSLLYWAINLGVAIGPLLGGLLL-----------LYSFRLLFLAAAVLFLLAALVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 211 LRRKLEESPVFENDVATQPERDNINFLQIIRFYYKDIFVCFVAVVFFNVTNymvtaYLPTYLEQVIKLDATTTSVLITCV 290
Cdd:cd17329 171 LFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLES-----TLPVYVVEILGLGESLLGLLLALN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 291 MAIMIPLALMFGKLADKigeKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHI 370
Cdd:cd17329 246 ALLIVLLQFPVARLVER---FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDK 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1450743514 371 RYRTLSVtFNISVSIFGGTTPLVATWLVTKTGdPLAPAYYLTAISVIGFLV 421
Cdd:cd17329 323 RGSYMGF-YALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAAL 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
264-345 |
2.84e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.22 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 264 VTAYLPTYLEQVIKLDATT--TSVLITCVMAImiPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVV-- 339
Cdd:COG2270 257 VIAFAGIYAAGVLGFSTTEliVFGLLVQIVAA--LGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWIlg 334
|
....*.
gi 1450743514 340 IVIGIF 345
Cdd:COG2270 335 LLIGLV 340
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
61-178 |
4.20e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.56 E-value: 4.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 61 LTFAALAIAFLlrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQiglwapilLLLARVLQGFSTGGEYA 140
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSV 106
|
90 100 110
....*....|....*....|....*....|....*...
gi 1450743514 141 GAMTYVAESSPDKRRNSLgsgleIGTLSGYIAASIMIA 178
Cdd:cd17320 107 VARAIVRDLYSGAELAKI-----FSLLMMILAIAPALA 139
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-175 |
4.54e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 31 WFDFGVYAYTTAYIGANFFSPV--ENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIG 108
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLyqEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 109 LLPSYDQIGLWAPILLLLarvlqGFSTGGEYAGAMTYVAESSPDKRRnslGSGLEIGTLSGYIAASI 175
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLL-----GFGFGLVFPALNALVSDLAPKEER---GTASGLYNTAGSLGGAL 342
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
282-350 |
5.06e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.18 E-value: 5.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1450743514 282 TTSVLItcVMAIMIPLAlmfGKLADKIGEKKVFLIGTGGLTLFSIIAFMllhSQSFVVIVIGIFILGFF 350
Cdd:cd17503 37 ITSYLL--ALAIMIPLS---GWLADRFGTRRLFLTALALFTLGSLLCGL---APNLASLIIFRILQGFG 97
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
298-422 |
5.46e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 5.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 298 ALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSV 377
Cdd:cd17370 251 AYPAGRLSDRIGRKKLLIL---GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL 327
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1450743514 378 tFNISVSIFGGTTPLVATWLVTKTGdPLAPAYYLTAISVIGFLVI 422
Cdd:cd17370 328 -FNTVVGIGWLLASLIAGYLWDLIS-PSAAFLFSAVLALIALLLL 370
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
78-175 |
9.78e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.45 E-value: 9.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 78 VVFGIIGDKYGRKVVLTSTIILMAFSTLtigLLPSYDQIGLWApilLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNS 157
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100
....*....|....*....|....*..
gi 1450743514 158 LG----SGLEIGT-----LSGYIAASI 175
Cdd:cd17318 148 LTsiaySGSQFGTviampLSGFLCESL 174
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
282-348 |
1.06e-03 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 41.05 E-value: 1.06e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1450743514 282 TTSVLITCVMAIMI---PLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVV--IVIGIFILG 348
Cdd:cd17482 222 GSSALILALLLTQFvafPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWIlaALIGLVQGG 293
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
59-171 |
1.14e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 40.94 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 59 QMLTFAALAIAFLLRPIGGvvfGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGE 138
Cdd:cd17435 38 QEMVVSSLLIGALLASLTG---GVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLS 106
|
90 100 110
....*....|....*....|....*....|....*..
gi 1450743514 139 YAGAMTYVAESSPDKRRNSLGSGLE----IGTLSGYI 171
Cdd:cd17435 107 SIATCVYIAEIAPQHRRGLLVSLNElmivIGILLAYI 143
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
77-195 |
1.19e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.07 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 77 GVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRN 156
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF--------WQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1450743514 157 S----------LGSGLeigtlsGYIAASIMIAvltffltdeqmASFGWR 195
Cdd:cd17328 123 RalgvfyfaipLGSGL------GYVVGGLVAQ-----------ATGGWR 154
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
75-195 |
1.26e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.98 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 75 IGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYAGAMTYvAESSPDKR 154
Cdd:cd17372 49 IGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNY--------MWLIILRCLVGLGLGGGPQLASWY-LEFLPAKS 119
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1450743514 155 RNSLGSGLEIGTLSGyiaaSIMIAVLTFFLtdeqMASFGWR 195
Cdd:cd17372 120 RGTWMVLFSVFWTVG----TIFEASLAWLV----MPRLGWR 152
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
61-159 |
2.90e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 39.64 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 61 LTFAALAIAFLlrpIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYdqiglwapILLLLARVLQGFSTGGEYA 140
Cdd:cd17379 37 LFQSSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWM 105
|
90
....*....|....*....
gi 1450743514 141 GAMTYVAESSPDKRRNSLG 159
Cdd:cd17379 106 TGYVLVTEFVGSKYRRTVG 124
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
70-372 |
2.95e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.11 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 70 FLLRPIGGVVFGIIGDKYGRKvvlTSTIILMAFSTLTIGLLPSYDQIGLwapILLLLARVLQGFSTGGEYAGAMTYVAES 149
Cdd:TIGR00894 86 FYGQIIIQIPVGYLAGKYVFK---WSIGIGMFLSSVISIVIPWAAGGGI---ALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 150 SPDKRRNSLG----SGLEIGT-----LSGYIAASIMIAVLTFFLTDEQMA--SFGWRI-----PFLLGLFLGLFGLYLRR 213
Cdd:TIGR00894 160 APPKERSRLLgmstSGFQLGTfiflpISGWLCESWGGWPMIFYVFGIVGCawSLLWFVfpaddPSIHPCISKFEKKYINS 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 214 KLEESPVfendvatqPERDNINFLQIIRfyYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAI 293
Cdd:TIGR00894 240 SLQGQKG--------STRQSLPIKAIPK--SLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLF 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 294 MIPLALMFGKLADKIGEKKVFLI--------GTGGLTLFSIIAFMLLHSQSFVVIVIgifilgfFLSTYEATMPGSLPTM 365
Cdd:TIGR00894 310 AWLCSIFAGYLADFLKSSKTLSLtaarkifnGIGGLGPGIFAYALPYLSAAFYLTII-------ILTLANAVSSGPLAGV 382
|
....*..
gi 1450743514 366 FYSHIRY 372
Cdd:TIGR00894 383 LINSLDL 389
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
263-354 |
4.56e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 263 MVTAYLPTYLEQvIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIgtgGLTLFSIIAFMLLHSQSFVVIVI 342
Cdd:cd17325 14 IIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLL---GLLLLAVSTLLFAFATSYWQLLL 89
|
90
....*....|..
gi 1450743514 343 GIFILGFFLSTY 354
Cdd:cd17325 90 ARFLQGLASAAV 101
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
61-350 |
4.57e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.28 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 61 LTFAALAIAFllrPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSydqigLWapiLLLLARVLQGFSTGGEYA 140
Cdd:TIGR00881 34 LLLSSFSIAY---GISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS-----LW---VMAALWALNGIFQGMGWP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 141 GAMTYVAESSPDKRRNSLGSGLEIG-TLSGYIAASIMIAVLTFFltdeqmasFGWRIPFLLGLFLGLFGLYL-------- 211
Cdd:TIGR00881 103 PCGRTVTKWFSRSERGTWVSFWNCShNVGGGLLPPLVLFGIAEL--------YSWHWVFIVPGIIAIIVSLIcflllrds 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 212 -----RRKLEESPVFENDVATQPERDNINFLQIIRFY---YKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTT 283
Cdd:TIGR00881 175 pqscgLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYvllNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKA 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1450743514 284 SVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTL--FSIIAFMLLHSQSFVVIVIGIFILGFF 350
Cdd:TIGR00881 255 SWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALiiVSLLVYWLNPAANPLMDLICLFALGFL 323
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
281-349 |
4.58e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 4.58e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1450743514 281 TTTSVLITCVMAIMIPLA---LMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMllhSQSFVVIVIGIFILGF 349
Cdd:cd17321 28 ASPSQLQWVVNAYLLAFAallLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL---APSLAFLIAARALQGI 96
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
52-155 |
5.38e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 52 VENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSydqiglwaPILLLLARVLQ 131
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS--------LWLLLLGFILW 297
|
90 100
....*....|....*....|....
gi 1450743514 132 GFSTGGEYAGAMTYVAESSPDKRR 155
Cdd:cd17370 298 GLYMGAQESIERAAVADLVPAELR 321
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
264-353 |
6.40e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.71 E-value: 6.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 264 VTAYLP--TYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLigtGGLTLFSIIAFMLLHSQSFVVIV 341
Cdd:cd17320 15 IDMYLPalPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLL---AGLLLFILASLLCALASSIEQLL 91
|
90
....*....|..
gi 1450743514 342 IGIFILGFFLST 353
Cdd:cd17320 92 IARFLQGLGAAA 103
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
287-353 |
6.84e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.84 E-value: 6.84e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1450743514 287 ITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMllhSQSFVVIVIGIFILGFFLST 353
Cdd:TIGR00898 133 QSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF---SPNYTVFLVFRLLVGMGIGG 196
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
80-362 |
7.80e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 7.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 80 FGIIGDKYGRKVvltstIILMAFSTLTIGLLPSYDQIGLWapiLLLLARVLQGfsTGGEYAGAMTYVAESSPDKRRNS-- 157
Cdd:cd17472 52 FGLLSDRIGRKP-----VILFGLLLFIAGSLLAAYATSIY---GLILGRALQG--SGAISSVVMALLADLTREENRTKam 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 158 --LGSGLEIGTLSGYIAASIMIAVLTF---FLTDEQMASFGWripfllglflglfgLYLRRKLEESPVFENDVATQPERd 232
Cdd:cd17472 122 alIGASIGIAFAISMVLGPLLAAHLGVsglFLITAILSLVSL--------------LILLFFVPDPPKIVQISEKEKKK- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 233 NINFLQIIRFYYKDIFVCFVavvffnvtNYMVTA---YLPTYLEQVIKLDATTTSVLiTCVMAIMIPLALMFGKLADKIG 309
Cdd:cd17472 187 LKKLLKNKRLLRLDFSIFIL--------HFVLMAffyILPLLLTQLGGGKGQLWKVY-LPAILIGFILMVPFVIYAEKKG 257
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1450743514 310 E-KKVFLIGTggLTLFSIIAFMLLHSQSFVVIVIG--IFILGFFLstYEATMPGSL 362
Cdd:cd17472 258 KmKQVFVSSI--LLIAVGFLLLLFAATSLWLLIIGliIFFIGFNL--LEALLPSLV 309
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
261-345 |
8.10e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 8.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 261 NYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGT-------GGLTLF-SIIAFMLL 332
Cdd:cd17471 215 NSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFlagvlfyLGLALAtSLWQLIAL 294
|
90
....*....|...
gi 1450743514 333 hsQSFVVIVIGIF 345
Cdd:cd17471 295 --QLLNAIFIGIT 305
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
262-350 |
9.81e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.38 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1450743514 262 YMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIV 341
Cdd:cd17345 248 YGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDL 327
|
....*....
gi 1450743514 342 IGIFILGFF 350
Cdd:cd17345 328 IALIALGFL 336
|
|
| |
