NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1451060018|dbj|GBY38644|]
View 

monovalent cation antiporter-2 [Staphylococcus aureus]

Protein Classification

monovalent cation:proton antiporter family protein( domain architecture ID 11422111)

monovalent cation:proton antiporter family protein such as Na/H antiporters which are key transporters in maintaining the pH of actively metabolising cells, and glutathione-regulated potassium-efflux system proteins that confer protection against electrophiles and catalyzes K+/H+ antiport

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 4.71e-67

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


:

Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 223.49  E-value: 4.71e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG0475     6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  83 KRArqgqnddessipgHLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475    83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGLSLAA--ALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 163 ILLVAVLADLVTMILLTVYGAINGQG---GSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475   148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 240 LVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIPILIVAFII 319
Cdd:COG0475   228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060018 320 SKLIPVMFIRRWF--DMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLFPV 393
Cdd:COG0475   304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
TrkA super family cl33955
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 329-595 2.74e-17

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0569:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 82.81  E-value: 2.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 329 RRWFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPII----FKKLFPVPDEFNRKIEVs 404
Cdd:COG0569    22 LDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLealrRRRMERGIKKLKMHVII- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 405 lIGKNQLTIPIAQNLTSQLYDVTLYyRKDLSDRRQLSDDITMIEIAD-YEQDVLERLGLFDRDIVVCATNDDDINRKVAK 483
Cdd:COG0569   101 -IGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIEDADAVIAATGDDEANILACL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 484 LAKAHQVERVICRLESTTDDTELVDSGI-EIFSSYLSNKILLKGLIETPNMLNI--LSNVETSLYEIQMLNY-KYENIQL 559
Cdd:COG0569   179 LAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGDAEIVEVTVPEGsPLVGKTL 258

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1451060018 560 R--NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLI 595
Cdd:COG0569   259 KelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 4.71e-67

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 223.49  E-value: 4.71e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG0475     6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  83 KRArqgqnddessipgHLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475    83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGLSLAA--ALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 163 ILLVAVLADLVTMILLTVYGAINGQG---GSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475   148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 240 LVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIPILIVAFII 319
Cdd:COG0475   228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060018 320 SKLIPVMFIRRWF--DMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLFPV 393
Cdd:COG0475   304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 6-391 3.37e-62

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 210.57  E-value: 3.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   6 LVIVVLAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVER-DSILNILSTLGFIFLMFLSGLEIDFKAFKKDKR 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKL---PPIVGLIIAGILLGPSGLGLISEvDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  85 ArqgqnddessipgHLNLALTVFAFIMIISILLAYVFKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFIL 164
Cdd:pfam00999  78 S-------------ILLLALLGVLIPFVLIGLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 165 LVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQ-KLMDGTTQIGIRAVFALIILL 240
Cdd:pfam00999 145 GESVLNDGVAVVLLAVLLALaqgVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLItRFTDDDRELEVLLVLLLALLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 241 VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSLIkePKLLIIIPILIVAFIIS 320
Cdd:pfam00999 225 ALLAEALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNPLFFVLVGLSLDLSSLL--LSVWILVLLALVAILLG 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1451060018 321 KLIPVMFIRR--WFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLF 391
Cdd:pfam00999 303 RFLGVFLLLRllGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPLL 375
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 11-296 1.67e-33

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 129.31  E-value: 1.67e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  11 LAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKDKRARQGQn 90
Cdd:TIGR00932   2 LAAVLAVPLSRRLGI---PSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  91 ddessipGHLNLALTVFAFIMiisiLLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLA 170
Cdd:TIGR00932  78 -------GVLQVLVPGVLLGL----LLGHLLGLALGA--AVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 171 DLVTMILLTVYGAINGQGGST---IWLIGILVVFTAISYILGVQF---KRMSFLQKlmDGTTQIGIRAVFALIILLVALA 244
Cdd:TIGR00932 145 DIAVVPLLALLPLLATSASTEhvaLALLLLKVFLAFLLLVLLGRWllrPVLRLTAE--LRPSELFTAGSLLLMFGSAYFA 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1451060018 245 EGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGyGFFIPIFFIMVGVDLN 296
Cdd:TIGR00932 223 DLLGLSMALGAFLAGVVLSESEYRHKLESDLEPIG-GVLLPLFFISVGMSVD 273
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 329-595 2.74e-17

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 82.81  E-value: 2.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 329 RRWFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPII----FKKLFPVPDEFNRKIEVs 404
Cdd:COG0569    22 LDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLealrRRRMERGIKKLKMHVII- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 405 lIGKNQLTIPIAQNLTSQLYDVTLYyRKDLSDRRQLSDDITMIEIAD-YEQDVLERLGLFDRDIVVCATNDDDINRKVAK 483
Cdd:COG0569   101 -IGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIEDADAVIAATGDDEANILACL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 484 LAKAHQVERVICRLESTTDDTELVDSGI-EIFSSYLSNKILLKGLIETPNMLNI--LSNVETSLYEIQMLNY-KYENIQL 559
Cdd:COG0569   179 LAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGDAEIVEVTVPEGsPLVGKTL 258

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1451060018 560 R--NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLI 595
Cdd:COG0569   259 KelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-386 1.59e-12

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 70.69  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   4 LSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDS----------ILNILSTLGFIFLMFLSGLE 73
Cdd:PLN03159   46 LQLTLVVVTTRLLVFILKPFR---QPRVISEILGGVILGPSVLGQSEVFAntifplrsvmVLETMANLGLLYFLFLVGVE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  74 IDFKAFKKD-KRArqgqnddessipghLNLALTVFAFIMIISILLAYVF----KWLGLVDDVLLMVIIISTISLGVVVPT 148
Cdd:PLN03159  123 MDISVIRRTgKKA--------------LAIAIAGMALPFCIGLAFSFIFhqvsRNVHQGTFILFLGVALSVTAFPVLARI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 149 LKEMNIMRTTIGQFILLVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYIlgVQFKRMSFLQKLM--- 222
Cdd:PLN03159  189 LAEIKLINTELGRIAMSAALVNDMCAWILLALAIALaenDSTSLASLWVLLSSVAFVLFCFY--VVRPGIWWIIRRTpeg 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 223 DGTTQIGIRAVFALIILLVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIpSLIK 302
Cdd:PLN03159  267 ETFSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNV-TKIQ 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 303 EPKLLIIIPILIVAFIISKLIPVMFIRRWFDM--KTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVI-T 379
Cdd:PLN03159  346 GPATWGLLVLVIIMASAGKIMGTIIIAFFYTMpfREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAmT 425


                  ....*..
gi 1451060018 380 CVFVPII 386
Cdd:PLN03159  426 ALITPVV 432
trkA PRK09496
Trk system potassium transporter TrkA;
415-610 4.81e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 55.51  E-value: 4.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 415 IAQNLTSQLYDVTLYyRKDLSDRRQLSD--DITMIE--IADYeqDVLERLGLFDRDIVVCATNDDDINRKVAKLAKA-HQ 489
Cdd:PRK09496   15 LAENLSGENNDVTVI-DTDEERLRRLQDrlDVRTVVgnGSSP--DVLREAGAEDADLLIAVTDSDETNMVACQIAKSlFG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 490 VERVICRLEST--TDDTELVDS---GI-EIFSSYLSNKILLKGLIETPNMLNI-------LSNVETSLYEIQMLNYKYEN 556
Cdd:PRK09496   92 APTTIARVRNPeyAEYDKLFSKealGIdLLISPELLVAREIARLIEYPGALDVeefadgrVQLVEVKVYEGSPLVGKPLS 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1451060018 557 iQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:PRK09496  172 -DLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEF 224
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 561-610 3.24e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 44.91  E-value: 3.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1451060018 561 NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:pfam02080  21 NLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 4.71e-67

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 223.49  E-value: 4.71e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG0475     6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  83 KRArqgqnddessipgHLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475    83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGLSLAA--ALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 163 ILLVAVLADLVTMILLTVYGAINGQG---GSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475   148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 240 LVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIPILIVAFII 319
Cdd:COG0475   228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060018 320 SKLIPVMFIRRWF--DMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLFPV 393
Cdd:COG0475   304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 6-391 3.37e-62

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 210.57  E-value: 3.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   6 LVIVVLAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVER-DSILNILSTLGFIFLMFLSGLEIDFKAFKKDKR 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKL---PPIVGLIIAGILLGPSGLGLISEvDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  85 ArqgqnddessipgHLNLALTVFAFIMIISILLAYVFKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFIL 164
Cdd:pfam00999  78 S-------------ILLLALLGVLIPFVLIGLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 165 LVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQ-KLMDGTTQIGIRAVFALIILL 240
Cdd:pfam00999 145 GESVLNDGVAVVLLAVLLALaqgVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLItRFTDDDRELEVLLVLLLALLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 241 VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSLIkePKLLIIIPILIVAFIIS 320
Cdd:pfam00999 225 ALLAEALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNPLFFVLVGLSLDLSSLL--LSVWILVLLALVAILLG 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1451060018 321 KLIPVMFIRR--WFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLF 391
Cdd:pfam00999 303 RFLGVFLLLRllGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPLL 375
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 11-296 1.67e-33

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 129.31  E-value: 1.67e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  11 LAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKDKRARQGQn 90
Cdd:TIGR00932   2 LAAVLAVPLSRRLGI---PSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  91 ddessipGHLNLALTVFAFIMiisiLLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLA 170
Cdd:TIGR00932  78 -------GVLQVLVPGVLLGL----LLGHLLGLALGA--AVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 171 DLVTMILLTVYGAINGQGGST---IWLIGILVVFTAISYILGVQF---KRMSFLQKlmDGTTQIGIRAVFALIILLVALA 244
Cdd:TIGR00932 145 DIAVVPLLALLPLLATSASTEhvaLALLLLKVFLAFLLLVLLGRWllrPVLRLTAE--LRPSELFTAGSLLLMFGSAYFA 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1451060018 245 EGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGyGFFIPIFFIMVGVDLN 296
Cdd:TIGR00932 223 DLLGLSMALGAFLAGVVLSESEYRHKLESDLEPIG-GVLLPLFFISVGMSVD 273
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 3-400 2.79e-27

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 116.23  E-value: 2.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG4651     7 ITTIALILGLAAVLGLLAQRLR---QPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  83 KRArqgqnddesSIPGhlnlALTVFAFIMIISILLAYVFKWlGLVDDVL--LMVIIISTIslgVVVPTLKEMNIMRTTIG 160
Cdd:COG4651    84 RKI---------ALPG----ALLQIALTTLLGFGIALLLGW-SLGESLVfgLALSLSSTV---VLLKLLEDRGELDTLHG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 161 QFILLVAVLADLVTMILLTVYGAINGQGGSTIWLIGI----LVVFTAISYILGvqfKRmsFLQKLMDGTTQIGIRAVFAL 236
Cdd:COG4651   147 RIAVGWLIVQDLAVVLMLVLLPALAGGGGGLLGTLGLtllkVALFVALMLVVG---RR--VIPWLLHRVARTRSRELFLL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 237 IILLVALAEGVGAENI-----LGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIP 311
Cdd:COG4651   222 AVLAICLGVAYLAALFglsfaLGAFLAGMVLAESEYSHQAAAELLPLRD-AFAVLFFVSVGMLFDPSFLLENP---LPVL 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 312 ILIVAFIISKLIPVMFIRRWF--DMKTTIASAFLLT--STLSLVIAAAKISerLNAISAETSGILILSAVITCVFVPIIF 387
Cdd:COG4651   298 ALLLIVLIGKPLIAFLIVLALgyPLRTALLVGLSLAqiGEFSFILAALGLS--LGLLSEEAYQLILAVAILTIALSPYLI 375

                         410
                  ....*....|...
gi 1451060018 388 KKLFPVPDEFNRK 400
Cdd:COG4651   376 ALADPLYARLERR 388
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 329-595 2.74e-17

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 82.81  E-value: 2.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 329 RRWFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPII----FKKLFPVPDEFNRKIEVs 404
Cdd:COG0569    22 LDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLealrRRRMERGIKKLKMHVII- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 405 lIGKNQLTIPIAQNLTSQLYDVTLYyRKDLSDRRQLSDDITMIEIAD-YEQDVLERLGLFDRDIVVCATNDDDINRKVAK 483
Cdd:COG0569   101 -IGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIEDADAVIAATGDDEANILACL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 484 LAKAHQVERVICRLESTTDDTELVDSGI-EIFSSYLSNKILLKGLIETPNMLNI--LSNVETSLYEIQMLNY-KYENIQL 559
Cdd:COG0569   179 LAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGDAEIVEVTVPEGsPLVGKTL 258

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1451060018 560 R--NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLI 595
Cdd:COG0569   259 KelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-386 1.59e-12

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 70.69  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   4 LSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDS----------ILNILSTLGFIFLMFLSGLE 73
Cdd:PLN03159   46 LQLTLVVVTTRLLVFILKPFR---QPRVISEILGGVILGPSVLGQSEVFAntifplrsvmVLETMANLGLLYFLFLVGVE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  74 IDFKAFKKD-KRArqgqnddessipghLNLALTVFAFIMIISILLAYVF----KWLGLVDDVLLMVIIISTISLGVVVPT 148
Cdd:PLN03159  123 MDISVIRRTgKKA--------------LAIAIAGMALPFCIGLAFSFIFhqvsRNVHQGTFILFLGVALSVTAFPVLARI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 149 LKEMNIMRTTIGQFILLVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYIlgVQFKRMSFLQKLM--- 222
Cdd:PLN03159  189 LAEIKLINTELGRIAMSAALVNDMCAWILLALAIALaenDSTSLASLWVLLSSVAFVLFCFY--VVRPGIWWIIRRTpeg 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 223 DGTTQIGIRAVFALIILLVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIpSLIK 302
Cdd:PLN03159  267 ETFSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNV-TKIQ 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 303 EPKLLIIIPILIVAFIISKLIPVMFIRRWFDM--KTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVI-T 379
Cdd:PLN03159  346 GPATWGLLVLVIIMASAGKIMGTIIIAFFYTMpfREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAmT 425


                  ....*..
gi 1451060018 380 CVFVPII 386
Cdd:PLN03159  426 ALITPVV 432
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 2-297 2.51e-10

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 63.12  E-value: 2.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   2 EFLSLVIVVL-AAFLTPIIVNRLNINflpVVVAEILMGIVIGNSFLN-IVERDSILNiLSTLGFIFLMFLSGLEIDFKAF 79
Cdd:PRK03659    5 DLLTAGVLFLfAAVVAVPLAQRLGIG---AVLGYLLAGIAIGPWGLGfISDVDEILH-FSELGVVFLMFIIGLELNPSKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  80 KKDKRarqgqnddesSIPGhLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNimRTTI 159
Cdd:PRK03659   81 WQLRR----------SIFG-VGAAQVLLSAAVLAGLLMLTDFSWQAAV--VGGIGLAMSSTAMALQLMREKGMN--RSES 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 160 GQF---ILL---VAVLADLVTMILLTvygaiNGQGGSTIWLIGILVVFTAISYILGVQFkrmsFLQKLMDGTTQIGIRAV 233
Cdd:PRK03659  146 GQLgfsVLLfqdLAVIPALALVPLLA-----GSADEHFDWMKIGMKVLAFAGMLIGGRY----LLRPLFRFIAASGVREV 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1451060018 234 FALIILLVALA-----EGVGAENILGAFLAGVvvsLLNPDE---EMVEKLDSFGyGFFIPIFFIMVGVDLNI 297
Cdd:PRK03659  217 FTAAALLLVLGsalfmDALGLSMALGTFIAGV---LLAESEyrhELEIAIEPFK-GLLLGLFFISVGMALNL 284
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 5-386 3.26e-09

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 59.62  E-value: 3.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   5 SLVIVVLAAFLTPIIVnRLNinfLPVVVAEILMGIVIGNSFLNIV-ERDSILNiLSTLGFIFLMFLSGLEIDFKAFKKDK 83
Cdd:PRK03562   10 ALIYLGAAVLIVPIAV-RLG---LGSVLGYLIAGCIIGPWGLRLVtDVESILH-FAEFGVVLMLFVIGLELDPQRLWKLR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  84 RARQGQnddessipGHLNL---ALTVFAFIMIISIllayvfKWLglVDDVLLMVIIIStiSLGVVVPTLKEMNIMRTTIG 160
Cdd:PRK03562   85 RSIFGG--------GALQMvacGGLLGLFCMLLGL------RWQ--VALLIGLGLALS--STAIAMQAMNERNLMVTQMG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 161 Q--F-ILLVAVLA--DLVTMI-LLTVYGAinGQGGSTIWLIGILVVFTAISYILGVQFkrmsFLQKLMDGTTQIGIRAVF 234
Cdd:PRK03562  147 RsaFaILLFQDIAaiPLVAMIpLLAASGA--STTLGAFALSALKVAGALALVVLGGRY----VTRPALRFVARSGLREVF 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 235 -ALIILLV----ALAEGVGAENILGAFLAGVvvsLLNPDE---EMVEKLDSFGyGFFIPIFFIMVGVDLNIPSLIKEPkl 306
Cdd:PRK03562  221 tAVALFLVfgfgLLMEEVGLSMALGAFLAGV---LLASSEyrhALESDIEPFK-GLLLGLFFIAVGMSIDFGTLLENP-- 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 307 lIIIPILIVAFIISKLIPVMFIRRWFDM--KTTIASAFLLT--STLSLVI--AAAKIserlNAISAETSGILILSAVITC 380
Cdd:PRK03562  295 -LRILILLLGFLAIKIAMLWLLARPLGVprKQRRWFAVLLGqgGEFAFVVfgAAQMA----NVLEPEWAKLLTLAVALSM 369


                  ....*.
gi 1451060018 381 VFVPII 386
Cdd:PRK03562  370 AATPLL 375
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 13-390 3.54e-08

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 56.26  E-value: 3.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  13 AFLTPIIVNRLNINFLpvvVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKDKRArqgqndd 92
Cdd:PRK10669   18 AFILGMLANRLRISPL---VGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKDLMAVKSI------- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  93 esSIPGhlnlALTVFAFIMIISILLAYVFKW---LGLVDDVLLmviiiSTISLGVVVPTLKEMNIMRTTIGQFI---LLV 166
Cdd:PRK10669   88 --AIPG----AIAQIAVATLLGMALSAVLGWslmTGIVFGLCL-----STASTVVLLRALEERQLIDSQRGQIAigwLIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 167 AVLADLVTMILLTVYGAINGQGGSTI--------WLIGILVVFTAISYILGvqfKRMsfLQKLMDGTTQIGIRAVFALII 238
Cdd:PRK10669  157 EDLVMVLTLVLLPAVAGMMEQGDVGFatlavdlgITIGKVIAFIAIMMLVG---RRL--VPWILARSAATGSRELFTLSV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 239 LLVALAEGVGAENI------LGAFLAGVVvslLNPDE-------EMVEKLDSFGYgffipIFFIMVGVDLNIPSLIKEPk 305
Cdd:PRK10669  232 LALALGIAFGAVELfdvsfaLGAFFAGMV---LNESElshraahDTLPLRDAFAV-----LFFVSVGMLFDPMILIQQP- 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 306 llIIIPILIVAFIISKLIPVMFIRRWFD----MKTTIASAFLLTSTLSLVIAAAKISerLNAISAETSGILILSAVITCV 381
Cdd:PRK10669  303 --LAVLATLAIIVFGKSLAAFFLVRLFGhsrrTALTIAASLAQIGEFAFILAGLGMA--LNLLPQAGQNLVLAGAILSIM 378


                  ....*....
gi 1451060018 382 FVPIIFKKL 390
Cdd:PRK10669  379 LNPVLFTLL 387
trkA PRK09496
Trk system potassium transporter TrkA;
415-610 4.81e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 55.51  E-value: 4.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 415 IAQNLTSQLYDVTLYyRKDLSDRRQLSD--DITMIE--IADYeqDVLERLGLFDRDIVVCATNDDDINRKVAKLAKA-HQ 489
Cdd:PRK09496   15 LAENLSGENNDVTVI-DTDEERLRRLQDrlDVRTVVgnGSSP--DVLREAGAEDADLLIAVTDSDETNMVACQIAKSlFG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 490 VERVICRLEST--TDDTELVDS---GI-EIFSSYLSNKILLKGLIETPNMLNI-------LSNVETSLYEIQMLNYKYEN 556
Cdd:PRK09496   92 APTTIARVRNPeyAEYDKLFSKealGIdLLISPELLVAREIARLIEYPGALDVeefadgrVQLVEVKVYEGSPLVGKPLS 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1451060018 557 iQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:PRK09496  172 -DLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEF 224
trkA PRK09496
Trk system potassium transporter TrkA;
454-608 5.21e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 55.51  E-value: 5.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 454 QDVLERLGLFDRDIVVCATNDDDINRKVAKLAKAHQVERVICRLESTtDDTELVDS-GIEIfssYLS------NKIL--- 523
Cdd:PRK09496  287 QELLEEEGIDEADAFIALTNDDEANILSSLLAKRLGAKKVIALVNRP-AYVDLVEGlGIDI---AISprqataSEILrhv 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 524 LKGLIETpnmLNILSNVETSLYEIQMLNY-KYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIV-TGAKE 601
Cdd:PRK09496  363 RRGDIVA---VHSLRRGAAEAIEAVAHETsKVVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVfVLDKK 439


                  ....*..
gi 1451060018 602 YVDELKQ 608
Cdd:PRK09496  440 FVPDVEK 446
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
3-494 7.63e-07

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 51.89  E-value: 7.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018   3 FLSLVIVVLAAFLTPIIVNRLNInflPVVVAEILMGIVIGnSFLNIVERDSILNI--LSTLGFIFLMFLSGLEIDFKAFK 80
Cdd:COG0025     4 LLLILLLLLLGLLSQWLARRLKL---PAPLLLLLAGILLG-PGLGLELDPELGDLepLLELFLPPLLFEAALNLDLRELR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018  81 KDKRArqgqnddessipghlnlaLTVFAFI-MIISILL-AYVFKWLGLVDDVLLMVI--IISTISLGVVVPTLKEMNImR 156
Cdd:COG0025    80 RNGRP------------------ILRLAVVgVLLTTLAvALAAHWLLGLPLAAALLLgaILAPTDPVAVSPILRRLGV-P 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 157 TTIGQFILLVAVLAD-LVTMILLTVYGAINGQGGSTIWLIGILVVFTAISYILGVQFKRMS--FLQKLMDGTTQIGIraV 233
Cdd:COG0025   141 KRLRTILEGESLLNDaTALVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGWLLgrLLRRLPDPLLEILL--T 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 234 FALIILLVALAEGVGAENILGAFLAGVVVSLLNPD-------EEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLikEPKL 306
Cdd:COG0025   219 LALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRslspetrLQLLEFWETLEF-LLNSLLFVLLGAQLPLILL--GALG 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 307 LIIIPILIVAFIISKLIPVMFIRRWFDMKTTIASAFLLTS-----TLSLVIAAAKISERLNAISAE------TSGILILS 375
Cdd:COG0025   296 LGGILLVLLALLVVRPLWVFLSLALRGSRLSWRERLFLSWggprgIVSLALALSLPLHGGAGFPGRdlilalAFGVILLT 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060018 376 AVITCVFVPIIFKKLFPVPDEFNRKIEVSLIGKNQLTIPIAQNLTSQLYDVTLYYRKDLSDRRQLSD--DITMIEIADYE 453
Cdd:COG0025   376 LVLQGLTLPPLARRLGLREDEPEGEELEAALARAALLELLAAELLADDEEVVLRAARRARRRREAAEllSEEAEEELDED 455

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1451060018 454 QDVLERLGLFDRDIVVCATNDDDINRKVAKLAKAHQVERVI 494
Cdd:COG0025   456 LLRLLLALLRLRLLNALAAARLERLLLRRRVEELLRLLERL 496
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 561-610 3.24e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 44.91  E-value: 3.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1451060018 561 NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:pfam02080  21 NLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
PRK05326 PRK05326
potassium/proton antiporter;
567-610 3.35e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 43.65  E-value: 3.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1451060018 567 DIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:PRK05326  440 GALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLF 483
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 564-610 3.87e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 43.19  E-value: 3.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1451060018 564 FGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:COG2985   226 LGTRVVISRIRRGGEIIVPTPDTVLQEGDIVLVVGTREALEAAEALL 272
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 558-608 4.56e-04

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 43.17  E-value: 4.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1451060018 558 QLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQ 608
Cdd:COG3263   430 TLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 561-610 3.34e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 40.49  E-value: 3.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1451060018 561 NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:COG2985   307 NLRNRFGVVITRVRRGGVELPATPDTVLQLGDRLTVVGPKEDVERVAKLL 356
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 450-490 3.74e-03

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 37.07  E-value: 3.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1451060018 450 ADYEQDvlerlgLFDRDIVVCATNDDDINRKVAKLAKAHQV 490
Cdd:pfam13241  53 REFEGD------LDGADLVIAATDDPELNERIAALARARGI 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH