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Conserved domains on  [gi|1451060021|dbj|GBY38647|]
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inorganic polyphosphate/ATP-NAD kinase [Staphylococcus aureus]

Protein Classification

NAD kinase( domain architecture ID 10012226)

ATP-dependent NAD kinase catalyzes the phosphorylation of NAD to NADP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-267 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


:

Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 521.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021   1 MRYTILTKGDSKSNALKHKMMNYMKDFRMIEDSENPEIVISVGGDGTLLQAFHQYSHMLSKVAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885    1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  81 HEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGYETrYLALNEATMKTENGsTLVVDVNLRGKHFERFRGDGLCVSTPSG 160
Cdd:PRK04885   81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEG-TLVADVYINGVLFERFRGDGLCVSTPTG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 161 STAYNKALGGALIHPSLEAMQITEIASINNRVFRTVGSPLVLPKHHTCLISPVNHDTIRMTIDHVSIKHKNVNSIQYRVA 240
Cdd:PRK04885  159 STAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVA 238

                         250       260
                  ....*....|....*....|....*..
gi 1451060021 241 NEKVRFARFRPFPFWKRVHDSFISSDE 267
Cdd:PRK04885  239 NEKIRFARFRHFPFWKRVKDSFIGEVE 265
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-267 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 521.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021   1 MRYTILTKGDSKSNALKHKMMNYMKDFRMIEDSENPEIVISVGGDGTLLQAFHQYSHMLSKVAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885    1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  81 HEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGYETrYLALNEATMKTENGsTLVVDVNLRGKHFERFRGDGLCVSTPSG 160
Cdd:PRK04885   81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEG-TLVADVYINGVLFERFRGDGLCVSTPTG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 161 STAYNKALGGALIHPSLEAMQITEIASINNRVFRTVGSPLVLPKHHTCLISPVNHDTIRMTIDHVSIKHKNVNSIQYRVA 240
Cdd:PRK04885  159 STAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVA 238

                         250       260
                  ....*....|....*....|....*..
gi 1451060021 241 NEKVRFARFRPFPFWKRVHDSFISSDE 267
Cdd:PRK04885  239 NEKIRFARFRHFPFWKRVKDSFIGEVE 265
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
31-263 1.41e-79

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 241.19  E-value: 1.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  31 EDSENPEIVISVGGDGTLLQAFHQYSHmlSKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMrYN 110
Cdd:COG0061    48 ELGEEADLVIVLGGDGTLLRAARLLAP--LGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATV-DR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 111 DNGYETRYLALNEATMKTEN-GSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIASIN 189
Cdd:COG0061   125 DGEVVHEALALNEVVVLRGSiARMIELEVYIDGEFLEEFRGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHT 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060021 190 NRVfrtvgSPLVLPKHHTCLISPVNH-DTIRMTIDH-VSIKHKNVNSIQYRVANEKVRFARFRPFPFWKRVHDSFI 263
Cdd:COG0061   205 LSS-----RPLVLPDDSEIEIEVLEDsRPAVLVADGqEVRDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKLG 275
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-185 2.40e-10

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 56.92  E-value: 2.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060021 121 LNEATMKTENGSTLV-VDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEI 185
Cdd:pfam20143   1 LNEVVYVRGPGATMIeFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPI 66
 
Name Accession Description Interval E-value
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 1-267 0e+00

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 521.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021   1 MRYTILTKGDSKSNALKHKMMNYMKDFRMIEDSENPEIVISVGGDGTLLQAFHQYSHMLSKVAFVGVHTGHLGFYADWLP 80
Cdd:PRK04885    1 MKVAIISNGDPKSKRVASKLKKYLKDFGFILDEKNPDIVISVGGDGTLLSAFHRYENQLDKVRFVGVHTGHLGFYTDWRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  81 HEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGYETrYLALNEATMKTENGsTLVVDVNLRGKHFERFRGDGLCVSTPSG 160
Cdd:PRK04885   81 FEVDKLVIALAKDPGQVVSYPLLEVKITYEDGEKEK-YLALNEATIKRIEG-TLVADVYINGVLFERFRGDGLCVSTPTG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 161 STAYNKALGGALIHPSLEAMQITEIASINNRVFRTVGSPLVLPKHHTCLISPVNHDTIRMTIDHVSIKHKNVNSIQYRVA 240
Cdd:PRK04885  159 STAYNKSLGGAVLHPSIEALQLTEIASINNRVFRTLGSPLILPKHHTITLKPVNDDDYQITVDHLTIKHKNVKSIEYRVA 238

                         250       260
                  ....*....|....*....|....*..
gi 1451060021 241 NEKVRFARFRPFPFWKRVHDSFISSDE 267
Cdd:PRK04885  239 NEKIRFARFRHFPFWKRVKDSFIGEVE 265
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
31-263 1.41e-79

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 241.19  E-value: 1.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  31 EDSENPEIVISVGGDGTLLQAFHQYSHmlSKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMrYN 110
Cdd:COG0061    48 ELGEEADLVIVLGGDGTLLRAARLLAP--LGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATV-DR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 111 DNGYETRYLALNEATMKTEN-GSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIASIN 189
Cdd:COG0061   125 DGEVVHEALALNEVVVLRGSiARMIELEVYIDGEFLEEFRGDGLIVSTPTGSTAYNLSAGGPIVHPGLDALVLTPIAPHT 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060021 190 NRVfrtvgSPLVLPKHHTCLISPVNH-DTIRMTIDH-VSIKHKNVNSIQYRVANEKVRFARFRPFPFWKRVHDSFI 263
Cdd:COG0061   205 LSS-----RPLVLPDDSEIEIEVLEDsRPAVLVADGqEVRDLEPGDRVEIRRSPKPVRLLRLKDHSFFERLREKLG 275
ppnK PRK03501
NAD kinase;
26-263 2.34e-56

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 181.71  E-value: 2.34e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  26 DFRMIEDSENPEIVISVGGDGTLLQAFHQySHMLSKVAFVGVHT-GHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLE 104
Cdd:PRK03501   30 GFTVVDHPKNANIIVSIGGDGTFLQAVRK-TGFREDCLYAGISTkDQLGFYCDFHIDDLDKMIQAITKEEIEVRKYPTIE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 105 IimryNDNGyETRYLALNEATMKTENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITE 184
Cdd:PRK03501  109 V----TVDG-STSFYCLNEFSIRSSIIKTFVIDVYIDDLHFETFRGDGMVVSTPTGSTAYNKSVRGAVVDPLIPCFQVSE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 185 IASINNRVFRTVGSPLVLPKHHTCLISPVN----HDTIRMTIDHVSIKHknVNSIQYRVANEKVRFARFRPFPFWKRVHD 260
Cdd:PRK03501  184 LASLNNNTYRTLGSPFILSHERKLTLKIVQdgndYPIIGMDNEALSIKH--VEKIDIRLSDKQIKTVKLKDNSFWEKVKR 261


                  ...
gi 1451060021 261 SFI 263
Cdd:PRK03501  262 TFL 264
pnk PRK14077
NAD(+) kinase;
27-248 9.65e-33

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 121.04  E-value: 9.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  27 FRMIEDSENPEIVISVGGDGTLLQAFHQYSHmlSKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQvIEYP-LLEI 105
Cdd:PRK14077   56 YGLDELFKISDFLISLGGDGTLISLCRKAAE--YDKFVLGIHAGHLGFLTDITVDEAEKFFQAFFQGEFE-IEKPyMLSV 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 106 IMRYNDnGYETRYLALNEAT-MKTENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITE 184
Cdd:PRK14077  133 FLEKKQ-GKILEKLAFNDVViSKNNQASMAHIEAFLNEKYFNEYFGDGVIVATPAGSTAYNMSANGPIIYPLSQVFILTP 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060021 185 IA--SINNRvfrtvgsPLVLPKHHTCLISpVNHDTIRMTIDHVSIKHKNVNSIQYRVANEKVRFAR 248
Cdd:PRK14077  212 VCshSLTQR-------PIVLPKGFEVEFK-TKSDCILCIDGQDRYKMNDFKSIKVGLSDKNVALIR 269
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 36-203 9.09e-31

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 115.79  E-value: 9.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  36 PEIVISVGGDGTLLQAFHQYSHmlSKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMRyNDNGYE 115
Cdd:PRK01911   65 ADMVISIGGDGTFLRTATYVGN--SNIPILGINTGRLGFLATVSKEEIEETIDELLNGDYTIEERSLLQLESN-PKLFGE 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 116 TRYlALNEATM-KTENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIA--SINNRv 192
Cdd:PRK01911  142 LNF-ALNEIAIlKRDTSSMITVHTYLNGEYLNSYWADGLIVATPTGSTGYSLSCGGPIIVPDAKSFVITPIAphNLNVR- 219

                         170
                  ....*....|.
gi 1451060021 193 frtvgsPLVLP 203
Cdd:PRK01911  220 ------PLVIP 224
ppnK PRK01185
NAD(+) kinase;
1-263 3.14e-25

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 100.66  E-value: 3.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021   1 MRYTILTKGDSKS--NALKHKMMNYMKDFRMIEDSE---------------NPEIVISVGGDGTLLQAFHqyshmLSKVA 63
Cdd:PRK01185    1 MKVAFVIRKDCKRciKIAKSIIELLPPDWEIIYEMEaakalgmdgldieeiNADVIITIGGDGTILRTLQ-----RAKGP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  64 FVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMryndNGyETRYLALNEATMKTENGSTLVVDVNLRGK 143
Cdd:PRK01185   76 ILGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDERMKLKVYI----NG-ERLEDCTNEAVIHTDRIAKIRQFKIYYDG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 144 HF-ERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIASINNRVfrtvgSPLVLPKHHTCLISPVNHDTIRMTI 222
Cdd:PRK01185  151 HFlDTFKADGVIVATPTGSTSYSSSAGGPILLPNLEGMVISYIAPYSSRP-----KSVVVPSESTVEIKIAGDQSSLLIL 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1451060021 223 D---HVSIKHKNVNSIqyRVANEKVRFARFRPFPFwKRVHDSFI 263
Cdd:PRK01185  226 DgqyEYKISKGDTVEI--SKSENYARFISFRESPY-DRIREKLI 266
ppnK PRK00561
NAD(+) kinase;
1-204 1.41e-23

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 96.10  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021   1 MRYTILTKGDSKSNALKHKMMNYMKDFRMIEDseNPEIVISVGGDGTLLQAFHQYSHMLSKVafVGVHTGHLGFYADWLP 80
Cdd:PRK00561    1 MKYKIFASTTPQTEPVLPKLKKVLKKKLAVED--GADYLFVLGGDGFFVSTAANYNCAGCKV--VGINTGHLGFYTSFNE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  81 HEVEKLIIeinnSEFQVIEYPLLEIIMRYNDNgyeTRYLALNEATMKTEngSTLVVDVNLRGKHFERFRGDGLCVSTPSG 160
Cdd:PRK00561   77 TDLDQNFA----NKLDQLKFTQIDLLEVQIDD---QIHLVLNELAVYTN--TAYPINIFIDNEFWEKYRGSGLLIGPRTG 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1451060021 161 STAYNKALGGALIHPSLEAMQITEIASINNRVFRTVGSPLVLPK 204
Cdd:PRK00561  148 STALAKSAKGAVIFPRIDVIQIIELNPLLHPNQTTIQSPIILPI 191
ppnK PRK01231
NAD(+) kinase;
37-180 2.30e-22

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 93.48  E-value: 2.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  37 EIVISVGGDGTLLQAfhqySHMLSK--VAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGY 114
Cdd:PRK01231   64 DLVIVVGGDGSLLGA----ARALARhnVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEAEVRRGGEVI 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1451060021 115 ETRyLALNEATMKTENGSTLV-VDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAM 180
Cdd:PRK01231  140 GQG-DALNDVVLHPGKSTRMIeFELYIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPIMHPKLDAI 205
pnk PRK14075
NAD(+) kinase;
1-186 2.89e-21

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 89.79  E-value: 2.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021   1 MRYTILTKGDSKSNA--LKHKMMNYMKDFRMIEDSENP----EIVISVGGDGTLLQAFHQYSHMLskvafVGVHTGHLGF 74
Cdd:PRK14075    1 MKLGIFYREEKEKEAkfLKEKISKEHEVVEFCEASASGkvtaDLIIVVGGDGTVLKAAKKVGTPL-----VGFKAGRLGF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  75 YADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMRYNDngyetrYLALNEATM-KTENGSTLVVDVNLRGKHFERFRGDGL 153
Cdd:PRK14075   76 LSSYTLEEIDRFLEDLKNWNFREEKRWFLKIESELGN------HLALNDVTLeRDPSQKMVEIEVSFEDHSSMWFFADGV 149

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1451060021 154 CVSTPSGSTAYNKALGGALIHPSLEAMQITEIA 186
Cdd:PRK14075  150 VISTPTGSTAYSLSLGGPIILPNCEVFEITPIA 182
ppnK PRK02645
NAD(+) kinase;
33-213 6.42e-21

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 89.59  E-value: 6.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  33 SENPEIVISVGGDGTLLQAFHQYS-HMLSKVAF-VGvhtGHLGFyadwLPHEV-----EKLIIEINNSEFQVIEYPLLEI 105
Cdd:PRK02645   55 SELIDLAIVLGGDGTVLAAARHLApHDIPILSVnVG---GHLGF----LTHPRdllqdESVWDRLQEDRYAIERRMMLQA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 106 IM----RYNDNGYETRYLALNEATMKTENG-----STLVVDVNlrGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPS 176
Cdd:PRK02645  128 RVfegdRSNEEPVSESYYALNDFYLKPASEdrsptCILELEID--GEVVDQYQGDGLIVSTPTGSTAYTMAAGGPILHPG 205

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1451060021 177 LEAMQITEIA--SINNRvfrtvgsPLVLPKHHTCLISPV 213
Cdd:PRK02645  206 IDAIIVTPICpmSLSSR-------PIVIPPGSRVVIWPL 237
ppnK PRK02155
NAD kinase;
40-203 1.07e-19

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 86.15  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  40 ISVGGDGTLL---QAFHQYShmlskVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEI-IMRYNDNGYE 115
Cdd:PRK02155   68 VVLGGDGTMLgigRQLAPYG-----VPLIGINHGRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLEArVVRDGEPIFH 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 116 TryLALNEATMKTENGSTLV-VDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIA--SINNRv 192
Cdd:PRK02155  143 A--LAFNDVVVNRSGFSGMVeLRVSVDGRFMYNQRSDGLIVATPTGSTAYALSAGGPILHPQLPGWVLVPIAphTLSNR- 219

                         170
                  ....*....|.
gi 1451060021 193 frtvgsPLVLP 203
Cdd:PRK02155  220 ------PIVLP 224
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
16-185 1.86e-19

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 87.48  E-value: 1.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  16 LKHKMMNYM-KDFRMIEDSENPEIVISVGGDGTLLQAfhqySHMLS--KVAFVGVHTGHLGFYADWLPHEVEKLIIEINN 92
Cdd:PRK14076  328 LYNKLKNRLnEECNLIDDIEEISHIISIGGDGTVLRA----SKLVNgeEIPIICINMGTVGFLTEFSKEEIFKAIDSIIS 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  93 SEFQVIEYPLLeIIMRYNDNGYETRYLALNEATMKTENGSTLV-VDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGA 171
Cdd:PRK14076  404 GEYEIEKRTKL-SGFILKDGHQNILPSALNEVVITTKNPAKMLhFEVYVNGELVEEVRADGIIISTPTGSTAYSLSAGGP 482

                         170
                  ....*....|....
gi 1451060021 172 LIHPSLEAMQITEI 185
Cdd:PRK14076  483 IVEPTVDGFIIVPI 496
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-186 4.48e-18

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 81.89  E-value: 4.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  37 EIVISVGGDGTLLQAfHQYSHMLSkVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGYET 116
Cdd:PRK03372   74 ELVLVLGGDGTILRA-AELARAAD-VPVLGVNLGHVGFLAEAEAEDLDEAVERVVDRDYRVEERMTLDVTVRVGGEIVWR 151

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1451060021 117 RYlALNEATmkTENGSTL-VVDVNLR--GKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIA 186
Cdd:PRK03372  152 GW-ALNEAS--LEKADREgMLEVVLEvdGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLVVPLN 221
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 34-170 1.10e-17

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 79.86  E-value: 1.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  34 ENPEIVISVGGDGTLLQAFHQYshMLSKVAFVGVHTGHLGF----YADwlphevEKLIIEINNSEFQVIeYPLLeiiMRY 109
Cdd:PRK04761   24 EEADVIVALGGDGFMLQTLHRY--MNSGKPVYGMNRGSVGFlmneYSE------DDLLERIAAAEPTVL-HPLR---MTA 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1451060021 110 ND-NGYETRYLALNEATM--KTENGSTLVVDVNlrGK-HFERFRGDGLCVSTPSGSTAYNKALGG 170
Cdd:PRK04761   92 TDvSGEVHEALAINEVSLfrQTRQAAKLRISID--GKvRMEELVCDGVLVATPAGSTAYNLSAHG 154
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 37-191 2.98e-17

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 79.52  E-value: 2.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  37 EIVISVGGDGTLLQAFHQYSHMlsKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMRYNDNGYEt 116
Cdd:PRK04539   70 DLVAVLGGDGTFLSVAREIAPR--AVPIIGINQGHLGFLTQIPREYMTDKLLPVLEGKYLAEERILIEAALIREGKTAE- 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1451060021 117 RYLALNEATM-KTENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIA--SINNR 191
Cdd:PRK04539  147 RALALNDAVLsRGGAGQMIEFEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGLHAFTLVPICpqSMTNR 224
ppnK PRK02649
NAD(+) kinase;
40-256 2.32e-16

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 76.94  E-value: 2.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  40 ISVGGDGTLLQAFHQyshmlskVAFVG-----VHTGHLGF----YADWLPHEVEKLIieinNSEFQVIEYPLLEI-IMRY 109
Cdd:PRK02649   73 IVLGGDGTVLSAARQ-------LAPCGiplltINTGHLGFlteaYLNQLDEAIDQVL----AGQYTIEERTMLTVsVMRG 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 110 NDNGYETryLALNEATMKTENGSTLVvdvnlrgkHFERFRG---------DGLCVSTPSGSTAYNKALGGALIHPSLEAM 180
Cdd:PRK02649  142 DQLRWEA--LSLNEMVLHREPLTSMC--------HFEIAIGrhapvdiaaDGVILSTPTGSTAYSLSAGGPVITPDVPVL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 181 QITEIA--SINNRVfrtvgspLVLPKHHTCLISPVNHDTIRMTIDhvsikhKNV-------NSIQYRVANEKVRFARFRP 251
Cdd:PRK02649  212 QLTPICphSLASRA-------LVFSDSEPVTVFPATPERLVMVVD------GNAgcyvwpeDRVLIRRSPYPVRFIRLQD 278


                  ....*
gi 1451060021 252 FPFWK 256
Cdd:PRK02649  279 PEFFR 283
ppnK PRK03708
NAD(+) kinase;
35-249 2.38e-16

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 76.67  E-value: 2.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  35 NPEIVISVGGDGTLLQAFHQYShmlSKVAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEIIMryndNGy 114
Cdd:PRK03708   57 DVDFIIAIGGDGTILRIEHKTK---KDIPILGINMGTLGFLTEVEPEETFFALSRLLEGDYFIDERIKLRVYI----NG- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 115 ETRYLALNE-ATMKTENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIASinnrvF 193
Cdd:PRK03708  129 ENVPDALNEvVILTGIPGKIIHLKYYVDGELADEVRADGLIISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCP-----F 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1451060021 194 RTVGSPLVLPKHHTCLISPVNHD-TIRMTIDHVSIKHKNVNS-IQYRVANEKVRFARF 249
Cdd:PRK03708  204 KLSSRPMVVPSSSRIDVKLLRTGrEIILVIDGQYYEELPPDTeITIKKSPRKTKFVRF 261
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 29-180 3.24e-14

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 70.74  E-value: 3.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  29 MIEDSENPEIVISVGGDGTLLQAfhqySHMLSK--VAFVGVHTGHLGFYADWLPHEVEKLIIEINNSEFQVIEYPLLEI- 105
Cdd:PRK03378   57 LAEIGQQADLAIVVGGDGNMLGA----ARVLARydIKVIGINRGNLGFLTDLDPDNALQQLSDVLEGHYISEKRFLLEAq 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 106 IMRYNDngYETRYLALNEATMKTENGSTLVvdvnlrgkHFE-----RF----RGDGLCVSTPSGSTAYNKALGGALIHPS 176
Cdd:PRK03378  133 VCRHGQ--QKRISTAINEVVLHPGKVAHMI--------EFEvyiddNFafsqRSDGLIISTPTGSTAYSLSAGGPILTPS 202


                  ....
gi 1451060021 177 LEAM 180
Cdd:PRK03378  203 LDAI 206
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 37-207 2.23e-13

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 69.48  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  37 EIVISVGGDGTLLQAFHQYSHMLSKVafVGVHTGHLGF--------YADWLpHEVEKLIIEI---NNSEFQVIEYPllei 105
Cdd:PLN02935  264 DLVITLGGDGTVLWAASMFKGPVPPV--VPFSMGSLGFmtpfhseqYRDCL-DAILKGPISItlrHRLQCHIIRDA---- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021 106 imRYNDNGYETRYLALNEATMKTENGSTLVvdvNLR----GKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQ 181
Cdd:PLN02935  337 --AKNEYETEEPILVLNEVTIDRGISSFLT---NLEcycdNSFVTCVQGDGLILSTTSGSTAYSLAAGGSMVHPQVPGIL 411

                         170       180
                  ....*....|....*....|....*.
gi 1451060021 182 ITEIASiNNRVFRtvgsPLVLPKHHT 207
Cdd:PLN02935  412 FTPICP-HSLSFR----PLILPEYVT 432
ppnK PRK02231
NAD(+) kinase;
37-180 7.82e-13

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 66.75  E-value: 7.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  37 EIVISVGGDGTLLQafhqYSHMLSK--VAFVGVHTGHLGFYADWLPHEV-EKLIIEINNSEFQVIEYPLLEIIMRYNDNG 113
Cdd:PRK02231   44 QLAIVIGGDGNMLG----RARVLAKydIPLIGINRGNLGFLTDIDPKNAyEQLEACLERGEFFVEERFLLEAKIERNGKI 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1451060021 114 YETRYlALNEATMK-TENGSTLVVDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAM 180
Cdd:PRK02231  120 IATSN-ALNEVVIHpAKIAHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAI 186
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 121-185 2.40e-10

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 56.92  E-value: 2.40e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1451060021 121 LNEATMKTENGSTLV-VDVNLRGKHFERFRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEI 185
Cdd:pfam20143   1 LNEVVYVRGPGATMIeFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPI 66
PLN02727 PLN02727
NAD kinase
 149-203 1.16e-07

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 52.58  E-value: 1.16e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1451060021 149 RGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQITEIASiNNRVFRtvgsPLVLP 203
Cdd:PLN02727  862 QGDGVIVATPTGSTAYSTAAGGSMVHPNVPCMLFTPICP-HSLSFR----PVILP 911
PLN02929 PLN02929
NADH kinase
 26-181 1.80e-03

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 38.86  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  26 DFRMIEDSE------NPEIVISVGGDGTLLQAFHqysHMLSKVAFVGVH---------------------TGHLG----- 73
Cdd:PLN02929   49 DWECVLRNElsqpirDVDLVVAVGGDGTLLQASH---FLDDSIPVLGVNsdptqkdeveeysdefdarrsTGHLCaatae 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1451060021  74 ---------FYADWLPHEVEKLIIEINNsefQVIEYPLLEIIMRYNDN-GYETRYlALNEATMKTENGSTLVVdvnlrgk 143
Cdd:PLN02929  126 dfeqvlddvLFGRLKPTELSRISTVVNG---TLLETPALNDVLIAHPSpAAVSRF-SFRVGRQGGSSGPLINV------- 194

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1451060021 144 hferfRGDGLCVSTPSGSTAYNKALGGALIHPSLEAMQ 181
Cdd:PLN02929  195 -----RSSGLRVSTAAGSTAAMLSAGGFPMPLLSRDLQ 227
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 37-92 6.14e-03

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 36.19  E-value: 6.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1451060021  37 EIVISVGGDGTLLQAfhqySHMLSKVA--FVGVHTGHLGFYADWLPHEVEKLIIEINN 92
Cdd:pfam01513  75 DLIIVLGGDGTALRA----ARLLQKAVipILGVNTGVLGFLTEFEPEAAFELLERLLE 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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