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Conserved domains on  [gi|1618593760|dbj|GCU92600|]
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conjugal transfer protein TraA [Escherichia coli]

Protein Classification

type IV conjugative transfer system pilin TraA( domain architecture ID 10014387)

type IV conjugative transfer system pilin TraA functions as a receptor for CdiA-CT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13734 PRK13734
conjugal transfer pilin subunit TraA; Provisional
 1-119 5.15e-57

conjugal transfer pilin subunit TraA; Provisional


:

Pssm-ID: 237485  Cd Length: 120  Bit Score: 172.42  E-value: 5.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760   1 MNTVLSVQGASAPVEKKSFFSKFTCLNMLRLVRAVIPVAVLMMLFPELAMAAGKG-DLMAKGQETVKATFGKNSSIVKWI 79
Cdd:PRK13734    1 MNAVLSVQGASAPVKKKSFFSKFTRLNMLRLARAVIPVAVLMMFFPQLAMAGAGGqDLMASGNTTVKATFGKDSSVVKWV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1618593760  80 VLAEVLVGAVMYMMTKNIKFLVGFAILSVFIAVGMSVAGF 119
Cdd:PRK13734   81 VLAEVLVGAVMYMMTKNVKFLAGFAIISVFIAVGMSVVGL 120
 
Name Accession Description Interval E-value
PRK13734 PRK13734
conjugal transfer pilin subunit TraA; Provisional
 1-119 5.15e-57

conjugal transfer pilin subunit TraA; Provisional


Pssm-ID: 237485  Cd Length: 120  Bit Score: 172.42  E-value: 5.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760   1 MNTVLSVQGASAPVEKKSFFSKFTCLNMLRLVRAVIPVAVLMMLFPELAMAAGKG-DLMAKGQETVKATFGKNSSIVKWI 79
Cdd:PRK13734    1 MNAVLSVQGASAPVKKKSFFSKFTRLNMLRLARAVIPVAVLMMFFPQLAMAGAGGqDLMASGNTTVKATFGKDSSVVKWV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1618593760  80 VLAEVLVGAVMYMMTKNIKFLVGFAILSVFIAVGMSVAGF 119
Cdd:PRK13734   81 VLAEVLVGAVMYMMTKNVKFLAGFAIISVFIAVGMSVVGL 120
TraA pfam05513
TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced ...
 1-117 4.74e-42

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.


Pssm-ID: 283228  Cd Length: 120  Bit Score: 134.41  E-value: 4.74e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760   1 MNTVLSVQGASAPVEKK-SFFSK-FTCLNMLRLVRAVIPVAVLMMLFPELAMAAGKG-DLMAKGQETVKATFGKNSSIVK 77
Cdd:pfam05513   1 MNAILSVQGAAAPEKKKpSFLSRtFNKKKALKLAKAAIPAAALAAFFPDAAMAAGGAqDLMASGDATVKATFGKDSSAVK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1618593760  78 WIVLAEVLVGAVMYMMTKNIKFLVGFAILSVFIAVGMSVA 117
Cdd:pfam05513  81 WVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIAIGMAVA 120
TraA_TIGR TIGR02758
type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the ...
 23-119 1.02e-23

type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the pilus found in type IV conjugative transfer systems. This family is generally found in gammaproteobacteria. The pilins show considerable heterogeneity among the different conjugative plasmit types. All of them however contain an N-terminal part which is cleaved off by a leader peptidase (LepB, or similar) to result in a 68-78 amino acid product. Pilins may be further processed by acetylation (in F-like systems by the TraX protein) or by cyclization (in P-like systems by the TraF protein).


Pssm-ID: 131805  Cd Length: 93  Bit Score: 87.17  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760  23 FTCLNMLRLVRAVIPVAVLMMLFPELAMaagkgDLMAKGQETVKATFGKNSSIVKWIVLAEVLVGAVMYMMTKNIKFLV- 101
Cdd:TIGR02758   1 NTRMALLLGVTAIAALSALAAFQPALAA-----DLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWFAALg 75

                          90
                  ....*....|....*...
gi 1618593760 102 GFAILSVFIAVGMSVAGF 119
Cdd:TIGR02758  76 GFAGGSIFWNVGMALVGL 93
 
Name Accession Description Interval E-value
PRK13734 PRK13734
conjugal transfer pilin subunit TraA; Provisional
 1-119 5.15e-57

conjugal transfer pilin subunit TraA; Provisional


Pssm-ID: 237485  Cd Length: 120  Bit Score: 172.42  E-value: 5.15e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760   1 MNTVLSVQGASAPVEKKSFFSKFTCLNMLRLVRAVIPVAVLMMLFPELAMAAGKG-DLMAKGQETVKATFGKNSSIVKWI 79
Cdd:PRK13734    1 MNAVLSVQGASAPVKKKSFFSKFTRLNMLRLARAVIPVAVLMMFFPQLAMAGAGGqDLMASGNTTVKATFGKDSSVVKWV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1618593760  80 VLAEVLVGAVMYMMTKNIKFLVGFAILSVFIAVGMSVAGF 119
Cdd:PRK13734   81 VLAEVLVGAVMYMMTKNVKFLAGFAIISVFIAVGMSVVGL 120
TraA pfam05513
TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced ...
 1-117 4.74e-42

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.


Pssm-ID: 283228  Cd Length: 120  Bit Score: 134.41  E-value: 4.74e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760   1 MNTVLSVQGASAPVEKK-SFFSK-FTCLNMLRLVRAVIPVAVLMMLFPELAMAAGKG-DLMAKGQETVKATFGKNSSIVK 77
Cdd:pfam05513   1 MNAILSVQGAAAPEKKKpSFLSRtFNKKKALKLAKAAIPAAALAAFFPDAAMAAGGAqDLMASGDATVKATFGKDSSAVK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1618593760  78 WIVLAEVLVGAVMYMMTKNIKFLVGFAILSVFIAVGMSVA 117
Cdd:pfam05513  81 WVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIAIGMAVA 120
TraA_TIGR TIGR02758
type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the ...
 23-119 1.02e-23

type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the pilus found in type IV conjugative transfer systems. This family is generally found in gammaproteobacteria. The pilins show considerable heterogeneity among the different conjugative plasmit types. All of them however contain an N-terminal part which is cleaved off by a leader peptidase (LepB, or similar) to result in a 68-78 amino acid product. Pilins may be further processed by acetylation (in F-like systems by the TraX protein) or by cyclization (in P-like systems by the TraF protein).


Pssm-ID: 131805  Cd Length: 93  Bit Score: 87.17  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618593760  23 FTCLNMLRLVRAVIPVAVLMMLFPELAMaagkgDLMAKGQETVKATFGKNSSIVKWIVLAEVLVGAVMYMMTKNIKFLV- 101
Cdd:TIGR02758   1 NTRMALLLGVTAIAALSALAAFQPALAA-----DLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWFAALg 75

                          90
                  ....*....|....*...
gi 1618593760 102 GFAILSVFIAVGMSVAGF 119
Cdd:TIGR02758  76 GFAGGSIFWNVGMALVGL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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