plasmid partition protein [Escherichia coli]
Protein Classification
acetate and sugar kinases/Hsc70/actin family protein( domain architecture ID 99298)
acetate and sugar kinases/Hsc70/actin (ASKHA) family protein catalyzes phosphoryl transfer from ATP to their respective substrates
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| ASKHA_ATPase-like super family | cl49607 | ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ... |
1-319 | 1.86e-125 | |||||
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion. The actual alignment was detected with superfamily member pfam06406: Pssm-ID: 483947 [Multi-domain] Cd Length: 317 Bit Score: 361.76 E-value: 1.86e-125
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| Name | Accession | Description | Interval | E-value | ||||||
| StbA | pfam06406 | StbA protein; This family consists of several bacterial StbA plasmid stability proteins. |
1-319 | 1.86e-125 | ||||||
StbA protein; This family consists of several bacterial StbA plasmid stability proteins. Pssm-ID: 310773 [Multi-domain] Cd Length: 317 Bit Score: 361.76 E-value: 1.86e-125
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| ASKHA_NBD_ParM_R1-like | cd24022 | nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and ... |
3-320 | 1.77e-88 | ||||||
nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and similar proteins from ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Escherichia coli ParM, also called ParA locus 36 kDa protein, or protein StbA. It is a plasmid-encoded protein involved in the control of plasmid partition and required for accurate segregation of low-copy-number plasmid R1. Pssm-ID: 466872 [Multi-domain] Cd Length: 324 Bit Score: 267.99 E-value: 1.77e-88
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| Name | Accession | Description | Interval | E-value | ||||||
| StbA | pfam06406 | StbA protein; This family consists of several bacterial StbA plasmid stability proteins. |
1-319 | 1.86e-125 | ||||||
StbA protein; This family consists of several bacterial StbA plasmid stability proteins. Pssm-ID: 310773 [Multi-domain] Cd Length: 317 Bit Score: 361.76 E-value: 1.86e-125
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| ASKHA_NBD_ParM_R1-like | cd24022 | nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and ... |
3-320 | 1.77e-88 | ||||||
nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and similar proteins from ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Escherichia coli ParM, also called ParA locus 36 kDa protein, or protein StbA. It is a plasmid-encoded protein involved in the control of plasmid partition and required for accurate segregation of low-copy-number plasmid R1. Pssm-ID: 466872 [Multi-domain] Cd Length: 324 Bit Score: 267.99 E-value: 1.77e-88
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| ASKHA_NBD_ParM-like | cd10227 | nucleotide-binding domain (NBD) of the plasmid segregation protein ParM-like domain family; ... |
3-312 | 1.68e-18 | ||||||
nucleotide-binding domain (NBD) of the plasmid segregation protein ParM-like domain family; ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments. ParM-like proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains. Pssm-ID: 466825 [Multi-domain] Cd Length: 263 Bit Score: 83.34 E-value: 1.68e-18
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| ASKHA_NBD_ParM_pCBH-like | cd24025 | nucleotide-binding domain (NBD) of Clostridium botulinum plasmid segregation protein ParM and ... |
83-312 | 4.33e-14 | ||||||
nucleotide-binding domain (NBD) of Clostridium botulinum plasmid segregation protein ParM and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Clostridium botulinum pCBH plasmid segregation protein ParM, an actin-like polymerizing motor. pCBH ParM filament structure is far more complex in comparison to the known filament structures of actin, MreB, and other ParMs. It is bipolar and stiff and like microtubules. The 15 polymerizing strands are likely to exert greater combined force relative to typical two-stranded actin-like filaments. Pssm-ID: 466875 [Multi-domain] Cd Length: 326 Bit Score: 71.93 E-value: 4.33e-14
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| ASKHA_NBD_ParM_Psk41-like | cd24021 | nucleotide-binding domain (NBD) of Staphylococcus aureus pSK41 actin-like ParM protein and ... |
96-315 | 1.75e-09 | ||||||
nucleotide-binding domain (NBD) of Staphylococcus aureus pSK41 actin-like ParM protein and similar proteins from the ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Staphylococcus aureus pSK41 actin-like ParM protein, which is functionally homologous to R1 ParM, a known actin homologue, suggesting that it may also form filaments to drive partition. However, pSK41 ParM shows the strongest structural homology to the archaeal actin-like protein Thermoplasma acidophilum Ta0583, but not R1 ParM. Pssm-ID: 466871 [Multi-domain] Cd Length: 298 Bit Score: 57.68 E-value: 1.75e-09
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| ASKHA_NBD_ParM_Alp7A-like | cd24023 | nucleotide-binding domain (NBD) of Bacillus subtilis actin-like protein Alp7A and similar ... |
96-293 | 2.65e-09 | ||||||
nucleotide-binding domain (NBD) of Bacillus subtilis actin-like protein Alp7A and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Bacillus subtilis actin-like protein Alp7A, a plasmid partitioning protein that functions in plasmid segregation. The subfamily also includes Bacillus thuringiensis ParM hybrid fusion protein. Pssm-ID: 466873 [Multi-domain] Cd Length: 368 Bit Score: 57.73 E-value: 2.65e-09
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| ASKHA_NBD_ParM_Alp12-like | cd24026 | nucleotide-binding domain (NBD) of Clostridium tetani actin-like protein Alp12 and similar ... |
38-293 | 7.80e-06 | ||||||
nucleotide-binding domain (NBD) of Clostridium tetani actin-like protein Alp12 and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Clostridium tetani actin-like protein Alp12. It is a dynamically unstable force-generating motor involved in segregating the pE88 plasmid, which encodes the lethal tetanus toxin. Alp12 filaments have a unique polymer structure that is entirely different from F-actin and display dynamic behavior like microtubules. Alp12 can be repeatedly cycled between states of polymerization and dissociation, making it a novel candidate for incorporation into fuel-propelled nanobiopolymer machines. Pssm-ID: 466876 [Multi-domain] Cd Length: 308 Bit Score: 46.90 E-value: 7.80e-06
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| ASKHA_NBD_PilM-like | cd24004 | nucleotide-binding domain (NBD) of the PilM-like domain family; The PilM-like family includes ... |
138-285 | 8.11e-05 | ||||||
nucleotide-binding domain (NBD) of the PilM-like domain family; The PilM-like family includes type IV pilus inner membrane component PilM, cell division protein FtsA, and ethanolamine utilization protein EutJ. PilM is an inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. FtsA is an essential cell division protein that assists in the assembly of the Z ring. It may serve as the principal membrane anchor for the Z ring. It is also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN. EutJ may protect ethanolamine ammonia-lyase (EAL, eutB-eutC) from inhibition. It may also function in assembling the bacterial microcompartment and/or in refolding EAL, suggesting it may have chaperone activity. Members in PilM-like family belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains. Pssm-ID: 466854 [Multi-domain] Cd Length: 282 Bit Score: 43.44 E-value: 8.11e-05
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| ASKHA_NBD_PilM | cd24049 | nucleotide-binding domain (NBD) of type IV pilus inner membrane component PilM and similar ... |
138-285 | 2.24e-03 | ||||||
nucleotide-binding domain (NBD) of type IV pilus inner membrane component PilM and similar proteins; PilM is an inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus. In turn, PilM associates with PilN and facilitates PilM functionally relevant structural changes that differentially impacts PilM binding to PilB, PilT, and PilC. Pssm-ID: 466899 [Multi-domain] Cd Length: 339 Bit Score: 39.18 E-value: 2.24e-03
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| FtsA | pfam14450 | Cell division protein FtsA; FtsA is essential for bacterial cell division, and co-localizes to ... |
170-287 | 3.79e-03 | ||||||
Cell division protein FtsA; FtsA is essential for bacterial cell division, and co-localizes to the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains. The FtsA protein contains two structurally related actin-like ATPase domains which are also structurally related to the ATPase domains of HSP70 (see PF00012). FtsA has a SHS2 domain PF02491 inserted in to the RnaseH fold PF02491. Pssm-ID: 464177 [Multi-domain] Cd Length: 167 Bit Score: 37.70 E-value: 3.79e-03
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